GAIA-NCIt Terminology Files

The Global Alignment of Immunization safety Assessment in pregnancy (GAIA) is a global consortium coordinated by the Brighton Collaboration that focuses on developing common standards, guidance, and tools to strengthen programs of immunization in pregnancy. This work will enhance the science of vaccine research by providing standardized, validated, and objective methods for monitoring safety profiles and benefit-to-risk ratios of vaccines. These terminology sets are maintained and published as part of the NCI Thesaurus (NCIt).

The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and the National Cancer Institute Enterprise Vocabulary Services (NCI EVS) have been collaborating with GAIA since 2014, to help develop standard terminology related to Fetal and Neonatal Events, Maternal Events, and Pregnancy Events and Outcomes. This expands on the Pediatric Terminology joint effort, ongoing since 2009, to establish a core library of harmonized pediatric terms that enable clinical investigators to more readily compare and aggregate data across clinical research portfolios. To this end, terminology data and draft standards were developed as part of the National Cancer Institute Thesaurus (NCIt) by experts from the NICHD, NCI EVS, and other participants. All NCIt content is freely available without restriction.

This data is in the form of concepts, which contain a cluster of core information that includes:

Concepts are grouped in named subsets. The subset name identifies area(s) of interest, such as GAIA Pathways to Preterm Birth Level of Diagnostic Certainty Terminology or GAIA Preterm Birth Level of Diagnostic Certainty Terminology, which is then easily extracted from the larger NCI Thesaurus. Subsets are published monthly in multiple formats on the NCI EVS ftp site. A link is provided at the bottom of this page to submit new requests or modifications. Update notifications are available via a subscription to the list-serv, also found at the bottom of this page.

GAIA-NCIt Terminology files available on this NCI EVS ftp site ( include:

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