NCIt Code NCIt PT NICHD PEDS PT NICHD PEDS SY NCIt Definition NICHD Definition NCIt Code of NICHD Parent NICHD Parent PT NCIt Code of second NICHD Parent NICHD second Parent PT NCIt Code of NICHD Subset NICHD PT of NICHD Subset C62651 Allergen Allergen A substance that elicits an allergic reaction. C45306 Substance C96388 NICHD Childhood Immunization Terminology C114476 Allergic Reaction Allergic Reaction An immune response that occurs following re-exposure to an innocuous antigen, and that requires the presence of existing antibodies against that antigen. This response involves the binding of IgE to mast cells, and may worsen with repeated exposures. A hypersensitivity reaction triggered by exposure to a previously encountered foreign substance to which the individual has formed antibodies. C3507 Immune System Disorder C96388 NICHD Childhood Immunization Terminology C62761 Attenuated Bacteria Vaccine Attenuated Bacteria Vaccine Attenuated Live Bacterial Vaccine Any vaccine created by reducing the virulence of bacteria but still keeping the bacteria viable (live). In the production of an attenuated vaccine, the infectious agent is altered so that it becomes harmless or less virulent. This is in contrast to those vaccines produced by "killing" the pathogen (inactivated vaccine). C97116 Attenuated Live Vaccine C96388 NICHD Childhood Immunization Terminology C97116 Attenuated Live Vaccine Attenuated Live Vaccine Any vaccine created by reducing the virulence of the infectious agent but still keeping the agent viable (live). In the production of an attenuated vaccine, the infectious agent is altered so that it becomes harmless or less virulent. This is in contrast to those vaccines produced by killing the pathogen (inactivated vaccine). C923 Vaccine C96388 NICHD Childhood Immunization Terminology C1920 Attenuated Live Virus Vaccine Attenuated Live Virus Vaccine Live vaccines prepared from microorganisms which have undergone physical adaptation (e.g., by radiation or temperature conditioning) or serial passage in laboratory animal hosts or infected tissue/cell cultures, in order to produce avirulent mutant strains capable of inducing protective immunity. Live-attenuated vaccines are used when a CD8+ T Cell (cellular cytotoxicity) response is desired. C97116 Attenuated Live Vaccine C96388 NICHD Childhood Immunization Terminology C2890 Bacterial Infection Bacterial Disease An acute infectious disorder caused by gram positive or gram negative bacteria. Representative examples include pneumococcal, streptococcal, salmonella and meningeal infections. C26726 Infectious Disease C96388 NICHD Childhood Immunization Terminology C76205 Bordetella pertussis Bordetella pertussis A species of bacteria within the phylum Proteobacteria consisting of gram-negative aerobic coccobacillus that are the causative agent of pertussis. C14187 Bacteria C96388 NICHD Childhood Immunization Terminology C9039 Cervical Carcinoma Cervical Carcinoma A carcinoma arising from either the exocervical squamous epithelium or the endocervical glandular epithelium. The major histologic types of cervical carcinoma are: squamous carcinoma, adenocarcinoma, adenosquamous carcinoma, adenoid cystic carcinoma and undifferentiated carcinoma. C9305 Cancer|Malignant Neoplasm C96388 NICHD Childhood Immunization Terminology C3782 Cervical Intraepithelial Neoplasia Cervical Intraepithelial Neoplasia Squamous or glandular intraepithelial neoplasia that affects the cervical mucosal epithelium. There is no evidence of stromal invasion. According to the degree of cellular atypia and the associated architectural changes, it is classified as low or high grade. C3262 Neoplasm C96388 NICHD Childhood Immunization Terminology C97132 Chicken Pox Chicken Pox A contagious childhood disorder caused by the varicella zoster virus. It is transmitted via respiratory secretions and contact with chickenpox blister contents. It presents with a vesicular skin rush, usually associated with fever, headache, and myalgias. The pruritic fluid-filled vesicles occur 10-21 days after exposure and last for 3-4 days. An additional 3-4 days of malaise follows before the affected individual feels better. An individual is contagious 1-2 days prior to the appearance of the blisters until all blisters are crusted over. Generally, healthy individuals recover without complications. C96411 Pediatric Viral Infection C96407 Varicella Zoster Infection C96388 NICHD Childhood Immunization Terminology C2960 Condyloma Acuminatum Condyloma Acuminatum Condyloma Acuminatum|Genital Warts A sexually transmitted papillary growth caused by the human papillomavirus. It usually arises in the skin and mucous membranes of the perianal region and external genitalia. C3439 Viral Infection C96388 NICHD Childhood Immunization Terminology C37928 Confusion Confusion A mental state characterized by a lack of clear and orderly thought and behavior. Impaired orientation to person, place or time. C87124 Central Nervous System Signs and Symptoms C96388 NICHD Childhood Immunization Terminology C1455 Conjugate Vaccine Conjugate Vaccine A category of vaccines created by covalently attaching an antigen from an organism to a carrier protein from the same organism to aid in the delivery of the immunogen. C97125 Polysaccharide Vaccine C96388 NICHD Childhood Immunization Terminology C3724 Cystic Hygroma Cystic Hygroma Cystic Lymphangioma A benign lymphatic neoplasm usually arising from the neck and characterized by cystic dilation of the lymphatic vessels. C2978 Cyst C3262 Neoplasm C96388 NICHD Childhood Immunization Terminology C27644 Deafness Deafness An inherited or acquired condition characterized by the inability to hear in one or both ears. Inability to hear. C35731 Hearing Loss C96388 NICHD Childhood Immunization Terminology C9011 Dermoid Cyst Dermoid Cyst A mature teratoma characterized by the presence of a cyst which is lined by mature tissue resembling the epidermis and the epidermal appendages. It occurs in the ovary, testis, and extragonadal sites including central nervous system and skin. A benign hamartomatous tumor that possesses various epidermal derivatives and is due to sequestration of skin along the lines of embryonic closure. In neonates, it is most commonly congenital and located in the subcutaneous tissues of the head, neck, or trunk. C2978 Cyst C96388 NICHD Childhood Immunization Terminology C2987 Diarrhea Diarrhea Watery bowel movements. Watery bowel movements. C3368 Gastrointestinal System Signs and Symptoms C96388 NICHD Childhood Immunization Terminology C34541 Diphtheria Diphtheria A Gram-positive bacterial infection caused by Corynebacterium diphtheria. It usually involves the oral cavity, pharynx, and nasal cavity. Patients develop pseudomembranes in the affected areas and manifest signs and symptoms of an upper respiratory infection. The diphtheria toxin may cause myocarditis, polyneuritis, and other systemic effects. C2890 Bacterial Disease C96388 NICHD Childhood Immunization Terminology C91718 Diphtheria Toxoid/Tetanus Toxoid Vaccine Adsorbed Diphtheria Toxoid/Tetanus Toxoid Vaccine Adsorbed A vaccine containing detoxified tetanus toxoid and detoxified diphtheria toxoid adsorbed on aluminum phosphate with active immunizing activity against diphtheria and tetanus. Intramuscular injection with this vaccine activates the immune system to develop antibodies against tetanus toxin and diphtheria toxin. C96398 Toxoid Vaccine C96388 NICHD Childhood Immunization Terminology C91717 Diphtheria Toxoid/Tetanus Toxoid/Acellular Pertussis Vaccine Adsorbed Diphtheria Toxoid/Tetanus Toxoid/Acellular Pertussis Vaccine DTP vaccine|Diphtheria Toxoid Tetanus Toxoid Acellular Pertussis Vaccine Adsorbed A vaccine containing detoxified tetanus toxoid, detoxified diphtheria toxoid and acellular pertussis antigens, adsorbed on aluminum phosphate, with active immunizing activity against diphtheria, tetanus and pertussis. The acellular pertussis vaccine components, produced by Bordetella pertussis, are detoxified pertussis toxin (PT), filamentous hemagglutinin (FHA), pertactin (PRN) and fimbriae types 2 and 3 (FIM). Intramuscular injection with this vaccine activates the immune system to develop antibodies against tetanus toxin, diphtheria toxin and B. pertussis antigens. C2848 Polyvalent Vaccine C96388 NICHD Childhood Immunization Terminology C97122 Diphtheria Toxoid/Tetanus Toxoid/Inactivated Pertussis Vaccine Diphtheria Toxoid/Tetanus Toxoid/Inactivated Pertussis Vaccine DTP A vaccine containing detoxified tetanus toxoid, detoxified diphtheria toxoid and inactivated pertussis antigens. C2848 Polyvalent Vaccine C96388 NICHD Childhood Immunization Terminology C3038 Fever Fever Elevation of body temperature above normal due to inflammatory or immune responses. Elevation of body temperature above normal due to the production of more heat than the body is able to dissipate. C50589 Hyperthermia C96388 NICHD Childhood Immunization Terminology C80444 H1N1 Influenza H1N1 Influenza Swine flu An acute viral respiratory infection caused by a strain of influenza virus which is endemic in swine (pigs). Rarely reported in humans prior to 2009, the disease is caused by a mutated strain of swine influenza A (H1N1) virus. It is highly contagious and spreads mainly through coughing and sneezing. Signs and symptoms include fever, chills, coughing, sore throat headache, muscle ache, and generalized weakness. Antiviral medications are most effective in the first two days of the illness. C53482 Influenza C96388 NICHD Childhood Immunization Terminology C1126 Haemophilus Influenzae B Vaccine Haemophilus Influenzae B Vaccine Hib Vaccine|PRP vaccine A vaccine against serotype b of the Gram-negative bacterium H. influenzae (Hib). Hib vaccines contain polysaccharide-protein conjugate antigens that produce greater host immune responses than first-generation purified polysaccharide vaccine. These vaccines may differ with regard to use of protein carriers, polysaccharides, diluents, and preservatives. C1455 Conjugate Vaccine C96388 NICHD Childhood Immunization Terminology C3096 Hepatitis A Infection Hepatitis A Infection Hepatitis A Acute inflammation of the liver caused by the hepatitis A virus. It is highly contagious and usually contracted through close contact with an infected individual or their feces, contaminated food or water. C3439 Viral Infection C96388 NICHD Childhood Immunization Terminology C29090 Hepatitis A Vaccine Hepatitis A Vaccine An inactivated virus vaccine that provides active immunization against hepatitis A virus (HAV). Immunization with hepatitis A vaccine induces the formation of anti-HAV antibodies which provide protection against hepatitis A infection. C29694 Inactivated Vaccine C96388 NICHD Childhood Immunization Terminology C3097 Hepatitis B Infection Hepatitis B Infection Hepatitis B A viral infection caused by the hepatitis B virus. C3439 Viral Infection C96388 NICHD Childhood Immunization Terminology C29091 Hepatitis B Vaccine Hepatitis B Vaccine Recombinant Hepatitis B Vaccine A non-infectious mixture containing recombinant hepatitis B surface antigen (HBsAg) in a liquid vehicle. Immunization with the hepatitis B vaccine induces the formation of specific anti-hepatitis B antibodies and an active immunity against hepatitis B infection. C1572 Recombinant Viral Vaccine C96388 NICHD Childhood Immunization Terminology C1951 Human Papilloma Virus Vaccine Human Papilloma Virus Vaccine Recombinant Human Papilloma Virus Vaccine A recombinant vaccine of different types of HPV proteins which are well-conserved within types with a significant inter-type variation. C1572 Recombinant Viral Vaccine C96388 NICHD Childhood Immunization Terminology C14226 Human Papillomavirus Human Papillomavirus Human Papilloma Virus A strain of papillomavirus that can infect the skin and mucous membranes of humans. C14283 Virus C96388 NICHD Childhood Immunization Terminology C14338 Human Papillomavirus-16 Human Papillomavirus-16 A virus comprised of a protein coat (capsid) surrounding a circular, double-stranded DNA organized into coding and non-coding regions, which can induce skin and mucosal epithelial lesions. Human papillomavirus-16 (HPV16) has been directly linked to cervical cancer and is significantly associated with invasiveness. Progression from low- to high-grade neoplasia is often associated with the integration of the HPV16 genome into the host chromosome. C14226 Human Papillomavirus C96388 NICHD Childhood Immunization Terminology C14377 Human Papillomavirus-18 Human Papillomavirus-18 A virus comprised of a protein coat (capsid) surrounding a circular, double-stranded DNA organized into coding and non-coding regions, which can induce skin and mucosal epithelial lesions. Human papillomavirus-18 (HPV18) has been directly linked to cervical cancer and plays a role in the pathogenesis of the disease. The virus integrates its DNA at specific chromosomal locations, such as 8q24 and 12q15. The use of molecular markers for HPV18 infection may allow the identification of patients with early stage cervical cancer and those at high risk for disease recurrence. C14226 Human Papillomavirus C96388 NICHD Childhood Immunization Terminology C15258 Immunization Immunization Inoculating an individual with either killed or live agents to prevent contraction of a disease. C25218 Intervention or Procedure C96388 NICHD Childhood Immunization Terminology C91715 Inactivated Poliovirus Vaccine Inactivated Poliovirus Vaccine A vaccine consisting of inactivated poliovirus (IPV) types 1,2 and 3, with active immunizing activity against poliomyelitis. Upon intramuscular vaccination, inactivated poliovirus vaccine (IPV) activates the immune system to develop antibodies against polioviruses. C29694 Inactivated Vaccine C96388 NICHD Childhood Immunization Terminology C29694 Inactivated Vaccine Inactivated Vaccine A preparation of killed microorganisms that is intended to prevent or treat an infectious disease by inducing active immunity to the causative microorganism. C923 Vaccine C96388 NICHD Childhood Immunization Terminology C26726 Infectious Disorder Infectious Disease A disorder resulting from the presence and activity of a microbial, viral, or parasitic agent. It can be transmitted by direct or indirect contact. C2991 Disease or Disorder C96388 NICHD Childhood Immunization Terminology C53482 Influenza Influenza Flu An acute viral infection of the respiratory tract, occurring in isolated cases, in epidemics, or in pandemics; it is caused by serologically different strains of viruses (influenzaviruses) designated A, B, and C, has a 3-day incubation period, and usually lasts for 3 to 10 days. It is marked by inflammation of the nasal mucosa, pharynx, and conjunctiva; headache; myalgia; often fever, chills, and prostration; and occasionally involvement of the myocardium or central nervous system. C3439 Viral Infection C96388 NICHD Childhood Immunization Terminology C96408 Influenza Vaccination Influenza Vaccination The administration of live or attenuated influenza virus for the prophylaxis of influenza. C15258 Immunization C96388 NICHD Childhood Immunization Terminology C96402 Live Attenuated Influenza Vaccine Live Attenuated Influenza Vaccine Nasal Spray Flu Vaccine A vaccine that contains live attenuated influenza virus (LAIV) particles. This vaccine is administered intranasally for influenza prophylaxis. Not all populations are good candidates for LAIV; the very young, elderly, asthmatics and those with health impaired may be better treated with the trivalent inactivated vaccine that is administered intramuscularly. C1920 Attenuated Live Virus Vaccine C96388 NICHD Childhood Immunization Terminology C34797 Malaria Malaria A protozoan infection caused by the genus Plasmodium. There are four species of Plasmodium that can infect humans: Plasmodium falciparum, vivax, ovale, and malariae. It is transmitted to humans by infected mosquitoes. Signs and symptoms include paroxysmal high fever, sweating, chills, and anemia. Plasmodium parasite infection, characterized by fever, flu-like symptoms, anemia, and jaundice, that may be transmitted through infected mosquito bites, blood transfusion, organ transplant, contaminated needles or syringes, or before or during birth. C27864 Parasitic Infection C96388 NICHD Childhood Immunization Terminology C96406 Measles Measles Rubeola A highly contagious viral infection caused by the measles virus. Symptoms appear 8-12 days after exposure and include a rash, cough, fever and muscle pains that can last 4-7 days. Measles vaccines are available to provide prophylaxis, usually combined with mumps and rubella vaccines (MMR). C96411 Pediatric Viral Infection C96388 NICHD Childhood Immunization Terminology C96403 Measles/Mumps/Rubella Vaccine Measles/Mumps/Rubella Vaccine Measles Mumps Rubella Vaccine A trivalent vaccine containing live attenuated viruses that can cause measles, mumps and rubella. It is an injection administered subcutaneously in two separate doses. C1920 Attenuated Live Virus Vaccine C96388 NICHD Childhood Immunization Terminology C26828 Meningitis Meningitis A disorder characterized by acute inflammation of the meninges of the brain and/or spinal cord. Inflammation of the membranes surrounding the brain and spinal cord. C27582 Central Nervous System Infectious Disease C96388 NICHD Childhood Immunization Terminology C96391 Meningococcal Conjugate Vaccine MCV4 Meningococcal Conjugate Vaccine MCV4 Meningococcal Conjugate Vaccine MCV-4 A conjugate vaccine of meningococcal polysaccharide used for active immunization against invasive meningococcal disease caused by Neisseria meningiditis serogroups A, C, Y, and W-135. C1455 Conjugate Vaccine C96388 NICHD Childhood Immunization Terminology C96519 Meningococcal Polysaccharide Vaccine MPSV4 Meningococcal Polysaccharide Vaccine MPSV4 Meningococcal Polysaccharide Vaccine MPSV-4 A polysaccharide vaccine used to prevent contraction of meningococcal meningitis. C97125 Polysaccharide Vaccine C96388 NICHD Childhood Immunization Terminology C84392 Mental Retardation Mental Retardation A developmental disorder characterized by less than average intelligence and significant limitations in adaptive behavior with onset before the age of 18. A condition of arrested or incomplete development of the mind, which is especially characterized by impairment of skills manifested during the developmental period, which contribute to the overall level of intelligence, i.e. cognitive, language, motor, and social abilities. C92190 Pediatric Psychiatric Disorder C96388 NICHD Childhood Immunization Terminology C29888 Mumps Mumps A contagious viral infection caused by the mumps virus. Symptoms include swollen and tender parotid glands, fever, muscle aches and fatigue. Due to vaccination programs, mumps has become a rare disease. C96411 Pediatric Viral Infection C96388 NICHD Childhood Immunization Terminology C86605 Neisseria meningitidis Neisseria meningitidis A species of aerobic, Gram-negative, diplococci shaped bacteria assigned to the phylum Proteobacteria. This species is catalase and oxidase positive, non-hemolytic, non-pigmented, does not reduce nitrate or nitrite, does not synthesize polysaccharides, grows on blood, chocolate, or Muller-Hinton agar, and produces acid from glucose and maltose but not fructose, sucrose, mannose, or lactose. N. meningitidis, known commonly as meningococcus, is the causative agent of cerebrospinal meningitis, but is also associated with other human infections, but can be commensal in the oropharynx and nasopharynx of carriers. C14187 Bacteria C96388 NICHD Childhood Immunization Terminology C96401 Oral Polio Vaccine Oral Polio Vaccine A vaccine that contains live attenuated polio virus. It is administered orally as polio prophylaxis in many areas of the world, but not in the U.S. since 2000. C1920 Attenuated Live Virus Vaccine C96388 NICHD Childhood Immunization Terminology C3303 Pain Pain The sensation of discomfort, distress, or agony, resulting from the stimulation of specialized nerve endings. An unpleasant sensation associated with real or perceived physical or mental trauma. C100104 Sign or Symptom C96388 NICHD Childhood Immunization Terminology C27864 Parasitic Infection Parasitic Infection Parasitic Disease A successful invasion of a host by an organism that uses the host for food and shelter. C26726 Infectious Disease C96388 NICHD Childhood Immunization Terminology C96411 Childhood Viral Infection Pediatric Viral Infection Childhood Viral Disease A viral infection that occurs during childhood. C89328 Pediatric Disorder C3439 Viral Infection C96388 NICHD Childhood Immunization Terminology C1909 Pharmacologic Substance Pharmacologic Substance Any natural, endogenously-derived, synthetic or semi-synthetic compound with pharmacologic activity. A pharmacologic substance has one or more specific mechanism of action(s) through which it exerts one or more effect(s) on the human or animal body. They can be used to potentially prevent, diagnose, treat or relieve symptoms of a disease. Formulation specific agents and some combination agents are also classified as pharmacologic substances. C45306 Substance C96388 NICHD Childhood Immunization Terminology C97120 Pneumococcal 10-valent Conjugate Vaccine Pneumococcal 10-valent Conjugate Vaccine An active immunizing vaccine used to prevent infection by the bacterium Streptococcus pneumoniae. It is indicated for disease caused by serotypes 1, 5, 4, 6B, 7, 9V, 14, 18C, 19F, and 23F. C97123 Pneumococcal Conjugate Vaccine C96388 NICHD Childhood Immunization Terminology C97121 Pneumococcal 13-valent Conjugate Vaccine Pneumococcal 13-valent Conjugate Vaccine A pneumococcal conjugate vaccine containing 13 different strains of the bacterium Streptococcus pneumoniae, used in children and studied in immunocompromised patients for the prevention of pneumococcal disease. The pneumococcal 13-valent conjugate vaccine contains capsular antigen polysaccharides derived from the S. pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F that are individually conjugated to a nontoxic diphtheria cross-reactive material (CRM) carrier protein (CRM197). Upon vaccination, pneumococcal 13-valent conjugate vaccine induces active immunization against 13 different serotypes of S. pneumoniae and protects against pneumococcal disease. C97123 Pneumococcal Conjugate Vaccine C96388 NICHD Childhood Immunization Terminology C38141 Pneumococcal 7-Valent Conjugate Vaccine Pneumococcal 7-Valent Conjugate Vaccine An active immunizing agent used to prevent infection by the bacterium Streptococcus pneumoniae. Pneumococcal 7-valent conjugate vaccine consists of a solution of saccharides of the capsular antigens of Streptococcus serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F individually conjugated to diphtheria CRM 197 protein. C97123 Pneumococcal Conjugate Vaccine C96388 NICHD Childhood Immunization Terminology C97123 Pneumococcal Conjugate Vaccine Pneumococcal Conjugate Vaccine An active immunizing vaccine used to prevent infection by the bacterium Streptococcus pneumoniae. It consists of a solution of saccharides of the capsular antigens of Streptococcus serotypes individually conjugated to proteins. C1455 Conjugate Vaccine C96388 NICHD Childhood Immunization Terminology C1643 Pneumococcal Polyvalent Vaccine Pneumococcal Polyvalent Vaccine Pneumococcal 23-valent Polysaccharide Vaccine An polyvalent vaccine used to prevent infection by the bacterium Streptococcus pneumoniae. Pneumococcal polyvalent vaccine contains highly purified capsular antigens from the 23 most prevalent or invasive pneumococcal types of Streptococcus pneumoniae to ensure cross-protection. Following vaccination, protective capsular type-specific antibody levels typically develop by the third week; serotype-specific antibody levels generally decline after 5-10 years. C97125 Polysaccharide Vaccine C96388 NICHD Childhood Immunization Terminology C3333 Pneumonia Pneumonia An acute, acute and chronic, or chronic inflammation focally or diffusely affecting the lung parenchyma, due to infections (viruses, fungi, mycoplasma, or bacteria), treatment (e.g. radiation), or exposure (inhalation) to chemicals. Symptoms include cough, shortness of breath, fevers, chills, chest pain, headache, sweating, and weakness. A condition resulting from infection in one or both lungs. C3198 Lung Disorder C96388 NICHD Childhood Immunization Terminology C96409 Polio Vaccination Polio Vaccination The administration a series of either live or inactivated poliovirus for the prophylaxis of poliomyelitis. C15258 Immunization C96388 NICHD Childhood Immunization Terminology C35550 Acute Poliomyelitis Poliomyelitis Polio An acute infectious disorder that affects the nervous system. It is caused by the poliovirus. The virus spreads by direct contact, and can be prevented by prophylaxis with the polio vaccine. C96411 Pediatric Viral Infection C96388 NICHD Childhood Immunization Terminology C14259 Poliovirus Poliovirus An enterovirus comprised of an single-stranded positive sense RNA genome and a protein capsid. This virus is the human pathogen that causes poliomyelitis. C14283 Virus C96388 NICHD Childhood Immunization Terminology C97125 Polysaccharide Vaccine Polysaccharide Vaccine A category of vaccines that use the extracted and purified outer polysaccharide coat of the particular bacteria. C923 Vaccine C96388 NICHD Childhood Immunization Terminology C2848 Polyvalent Vaccine Polyvalent Vaccine A vaccine designed to elicit an immune response either to more than one infectious agent or to several different antigenic determinants of a single agent. C923 Vaccine C96388 NICHD Childhood Immunization Terminology C1572 Recombinant Viral Vaccine Recombinant Viral Vaccine A vaccine produced from genetically engineered viral vector by introduction of foreign genetic materials to activate immune response in a host. C923 Vaccine C96388 NICHD Childhood Immunization Terminology C4077 Redness Redness Coloration of the skin; sign of inflammation C100104 Sign or Symptom C96388 NICHD Childhood Immunization Terminology C92947 Rh Immune Globulin Administration Rh Immune Globulin Administration Rho(D) Immune Globulin Administration The administration of Rh Immune Globulin to a pregnant mother to ameliorate the effects of conflicting Rh factors during pregnancy. C49236 Therapeutic Procedure C96388 NICHD Childhood Immunization Terminology C77199 Rotavirus Rotavirus A genus of double stranded RNA viruses that carry 11 unique double helix molecules of RNA that encode one or two proteins each. The RNA is surrounded by a three-layered icosahedral protein capsid. Viral particles are up to 76.5 nm in diameter and are not enveloped. C14283 Virus C96388 NICHD Childhood Immunization Terminology C96394 Rotavirus Vaccine Rotavirus Vaccine A viral vaccine that prevents against rotavirus infection, the leading cause of severe acute gastroenteritis. C1920 Attenuated Live Virus Vaccine C96388 NICHD Childhood Immunization Terminology C92872 Rubella Immunization Rubella Immunization The administration of a live attenuated viral vaccine to prevent rubella infection. C15258 Immunization C96388 NICHD Childhood Immunization Terminology C85051 Rubella Infection Rubella Infection German Measles A viral infection caused by the rubella virus. It is initially manifested with flu-like symptoms that last one or two days, followed by the development of a characteristic red rash which lasts from one to five days. The rash first appears in the neck and face. It subsequently spreads to the rest of the body. C3439 Viral Infection C96388 NICHD Childhood Immunization Terminology C39594 Skin Rash Skin Rash Any change in the skin which affects its appearance or texture. A rash may be localized to one part of the body, or affect all the skin. Rashes may cause the skin to change color, itch, become warm, bumpy, dry, cracked or blistered, swell and may be painful. An eruption in the skin which affects its appearance or texture. C36281 Integumentary System Finding C100104 Sign or Symptom C96388 NICHD Childhood Immunization Terminology C85185 Tetanus Tetanus A serious infectious disorder that follows wound contamination by the Gram-positive bacterium Clostridium tetani. The bacteria produce a neurotoxin called tetanospasmin, which causes muscle spasm in the jaw and other anatomic sites. C2890 Bacterial Disease C96388 NICHD Childhood Immunization Terminology C96405 Tetanus and Diphtheria Toxoids Adsorbed Tetanus and Diphtheria Toxoids Adsorbed A sterile, intramuscular suspension of alum (aluminum potassium sulfate)-precipitated toxoids indicated for active immunization for the prevention of tetanus and diphtheria for use in persons 7 years of age or older. C96398 Toxoid Vaccine C96388 NICHD Childhood Immunization Terminology C2660 Tetanus Toxoid Vaccine Tetanus Toxoid Vaccine A preparation of formaldehyde-deactivated toxin isolated from the bacterium Clostridium tetani. Tetanus toxoid is used for booster injection and can stimulate the production of antitoxin antibodies. This agent may be used as an adjuvant in cancer vaccines. C96398 Toxoid Vaccine C96388 NICHD Childhood Immunization Terminology C96398 Toxoid Vaccine Toxoid Vaccine Any vaccine that contains an inactivated toxic substance used for disease prophylaxis or to vaccinate against snake bites. C923 Vaccine C96388 NICHD Childhood Immunization Terminology C2643 Trivalent Influenza Vaccine Trivalent Influenza Vaccine Flu prevention|Flu prophylaxis|Flu shot|Flu vaccination A synthetic vaccine consisting of three inactivated influenza viruses, two different influenza type A strains and one influenza type B strain. Trivalent influenza vaccine is formulated annually, based on influenza strains projected to be prevalent in the upcoming flu season. This agent may be formulated for injection or intranasal administration. C2848 Polyvalent Vaccine C96388 NICHD Childhood Immunization Terminology C97126 Ty21a Typhoid Vaccine Ty21a Typhoid Vaccine A live attenuated oral virus vaccine used to prevent typhoid, which is caused by Salmonella typhi. C62761 Attenuated Bacteria Vaccine C96388 NICHD Childhood Immunization Terminology C35089 Typhoid Fever Typhoid Fever A bacterial infectious disorder contracted by consumption of food or drink contaminated with Salmonella typhi. This disorder is common in developing countries and can be treated with antibiotics. C2890 Bacterial Disease C96388 NICHD Childhood Immunization Terminology C923 Vaccine Vaccine Preparations containing substances with antigenic properties administered to activate the immune system, thereby inducing an immune response. C307 Biologic Agent C96388 NICHD Childhood Immunization Terminology C96395 Varicella Vaccine Varicella Vaccine Chickenpox Vaccine|Shingles Vaccine A live attenuated virus vaccine used to prevent chickenpox and shingles, which is caused by varicella-zoster virus (VZV). C1920 Attenuated Live Virus Vaccine C96388 NICHD Childhood Immunization Terminology C71091 Varicella Zoster Virus Varicella Zoster Virus An icosahedral, enveloped virus containing a single molecule of linear double-stranded DNA of 125000 nucleotides that infects only humans. It is the causative agent of chickenpox and shingles. C14283 Virus C96388 NICHD Childhood Immunization Terminology C92915 Varicella Zoster Virus Immunization Varicella Zoster Virus Immunization Chickenpox Immunization The administration of a live attenuated viral vaccine to prevent herpes zoster infection. C15258 Immunization C96388 NICHD Childhood Immunization Terminology C97127 Vi Capsular Polysaccharide Typhoid Vaccine Vi Capsular Polysaccharide Typhoid Vaccine A live attenuated injectable virus vaccine used to prevent typhoid, which is caused by Salmonella typhi. C97125 Polysaccharide Vaccine C96388 NICHD Childhood Immunization Terminology C3439 Viral Infection Viral Infection Viral Disease Any disease caused by a virus. C26726 Infectious Disease C96388 NICHD Childhood Immunization Terminology C3442 Vomiting Vomiting Forceful ejection of the contents of the stomach through the mouth. Expulsion of the contents of the stomach through the mouth. C100104 Sign or Symptom C96388 NICHD Childhood Immunization Terminology C96396 Yellow Fever Vaccine Yellow Fever Vaccine A live, attenuated viral vaccine to prevent yellow fever, endemic to parts of Africa and South America. C1920 Attenuated Live Virus Vaccine C96388 NICHD Childhood Immunization Terminology C35547 Yellow Fever Virus Infection Yellow Fever Virus Infection A viral infection caused by a flavivirus called yellow fever virus. It is transmitted to humans from infected mosquitoes. The signs and symptoms range from a mild febrile illness to liver damage with jaundice and hemorrhages. C3439 Viral Infection C96388 NICHD Childhood Immunization Terminology C92621 Acute Stress Disorder Acute Stress Disorder An anxiety disorder precipitated by an experience of intense fear or horror while exposed to a traumatic (especially life-threatening) event. The disorder is characterized by dissociative symptoms; vivid recollections of the traumatic event; avoidance of stimuli associated with the traumatic event; and a constant state of hyperarousal for no more than one month. C2878 Anxiety Disorder C97150 NICHD Neurological Development Terminology C34362 Agoraphobia Agoraphobia An anxiety disorder characterized by an intense, irrational fear of venturing out into open places or situations in which help (or escape) might not be available should excessive anxiety or panic symptoms develop. C2878 Anxiety Disorder C97150 NICHD Neurological Development Terminology C34387 Anorexia Nervosa Anorexia Nervosa A disorder most often seen in adolescent females characterized by a refusal to maintain a minimally normal body weight, an intense fear of gaining weight, a disturbance in body image, and, in postmenarcheal females, the development of amenorrhea. C89332 Eating Disorder C97150 NICHD Neurological Development Terminology C2878 Anxiety Disorder Anxiety Disorder A category of psychiatric disorders which are characterized by anxious feelings or fear often accompanied by physical symptoms associated with anxiety. C2893 Psychiatric Disorder C97150 NICHD Neurological Development Terminology C97159 Asperger Syndrome Asperger Syndrome A disorder most often diagnosed in the pediatric years in which the individual displays marked impairment in social interaction and a repetitive, stereotyped pattern of behavior. The individual, however, displays no delay in language or cognitive development, which differentiates Asperger Syndrome from autism. C88412 Autism Spectrum Disorder C97150 NICHD Neurological Development Terminology C97168 Ataxic Cerebral Palsy Ataxic Cerebral Palsy The least common subtype of cerebral palsy, in which the individual displays hypotonia, a loss of motor coordination, and an intention tremor. Individuals with ataxic cerebral palsy walk very unsteadily, with a wide-based gait. A type of cerebral palsy characterized by decreased muscle tone, a loss of motor coordination and an intention tremor. C34460 Cerebral Palsy C97150 NICHD Neurological Development Terminology C97169 Athetoid Cerebral Palsy Athetoid Cerebral Palsy A subtype of cerebral palsy characterized by involuntary, purposeless writhing movements which affect the hands, feet, arms, and legs; the face and tongue may be affected as well, leading to involuntary grimacing, drooling, dysarthria and difficulty eating. A type of cerebral palsy characterized by involuntary, purposeless writhing movements that affect the hands, feet, arms, and legs; the face and tongue may be affected as well, leading to involuntary grimacing, drooling, dysarthria and difficulty eating. C34460 Cerebral Palsy C97150 NICHD Neurological Development Terminology C97160 Attention Deficit Hyperactivity Disorder Attention Deficit Hyperactivity Disorder A disorder characterized by a marked pattern of inattention and/or hyperactivity-impulsivity that is inconsistent with developmental level and clearly interferes with functioning in at least two settings (e.g. at home and at school). At least some of the symptoms must be present before the age of 7 years. A neurodevelopmental disorder presenting in early childhood that is characterized by chronic and excessive inattention, overactivity, and/or impulsivity. C35470 Behavioral Disorder C97150 NICHD Neurological Development Terminology C97161 Autism Autism A disorder characterized by marked impairments in social interaction and communication accompanied by a pattern of repetitive, stereotyped behaviors and activities. Developmental delays in social interaction and language surface prior to age 3 years. A neurodevelopmental disorder presenting in early childhood that is characterized by impaired communication, difficulty in social interactions, stereotypic behaviors, and a limited range of interests and activities. C88412 Autism Spectrum Disorder C97150 NICHD Neurological Development Terminology C88412 Autism Spectrum Disorder Autism Spectrum Disorder A spectrum of developmental disorders that includes autism, Asperger syndrome, and Rett syndrome. Signs and symptoms include poor communication skills, defective social interactions, and repetitive behaviors. Neurodevelopmental disorders presenting in childhood with classic symptoms of impairment in verbal and nonverbal communication, social interactions, and/or imaginative play. C97179 Pervasive Developmental Disorder C97150 NICHD Neurological Development Terminology C35470 Behavioral Disorder Behavioral Disorder A specific behavioral problem that occurs in persistent patterns and characteristic clusters and that causes clinically significant impairment. C2991 Disease or Disorder C97150 NICHD Neurological Development Terminology C97162 Binge Eating Binge Eating Recurrent episodes of over-eating. Binge eating with or without purging. C89332 Eating Disorder C97150 NICHD Neurological Development Terminology C34423 Bipolar Disorder Bipolar Disorder A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence. C2893 Psychiatric Disorder C97150 NICHD Neurological Development Terminology C97109 Blindness Blindness The lack of vision. It is caused by neurological or physiological factors. Profound visual impairment despite optimal refractive correction. C35126 Vision Disorder C97150 NICHD Neurological Development Terminology C96412 Brain Development Abnormality Brain Development Abnormality A group of congenital or acquired disorders that affect the normal development of the brain. C89338 Neurodevelopmental Disorder C97150 NICHD Neurological Development Terminology C96413 Brain Disorder Brain Disorder A non-neoplastic or neoplastic disorder that affects the brain. C2934 Central Nervous System Disorder C97150 NICHD Neurological Development Terminology C34440 Bulimia Nervosa Bulimia Nervosa A disorder characterized by recurrent episodes of binge-eating over which the individual feels a lack of control; these episodes of binge-eating are followed by recurrent compensatory behavior to prevent weight gain, usually self-induced vomiting. In addition, self-evaluation is unduly influenced by body image. Recurrent episodes of over-eating. C89332 Eating Disorder C97150 NICHD Neurological Development Terminology C97170 Central Auditory Processing Disorder Central Auditory Processing Disorder A disorder characterized by impairment of the auditory processing, resulting in deficiencies in the recognition and interpretation of sounds by the brain. Causes include brain maturation delays and brain traumas or tumors. C97155 Language Disorder C97150 NICHD Neurological Development Terminology C34662 Central Hearing Loss Central Hearing Loss Hearing loss resulting from disorders of the central nervous system auditory pathways. Hearing loss resulting from disorders of the central nervous system auditory pathways. C35731 Hearing Loss C97150 NICHD Neurological Development Terminology C2934 Central Nervous System Disorder Central Nervous System Disorder A non-neoplastic or neoplastic disorder which affects the brain and/or spinal cord. C26835 Nervous System Disorder C97150 NICHD Neurological Development Terminology C34460 Cerebral Palsy Cerebral Palsy A group of disorders affecting the development of movement and posture, often accompanied by disturbances of sensation, perception, cognition, and behavior. It results from damage to the fetal or infant brain. A group of permanent disorders of the development of movement and posture, causing activity limitation, that are attributed to non-progressive disturbances in the developing fetal or infant brain.|A non-progressive, neurological syndrome presenting in infancy or early childhood that is caused by brain injury or malformation and is characterized by permanent impairment of muscle coordination and various movement disorders. C26835 Nervous System Disorder C89328 Pediatric Disorder C97150 NICHD Neurological Development Terminology C97163 Childhood Depression Childhood Depression Similar to depression in adults, childhood depression is characterized by a prolonged depressed or irritable mood accompanied by a significant loss of interest in activities, changes in appetite or sleep, decreased energy, feelings of worthlessness, and/or recurrent thoughts of death or suicide. C92190 Pediatric Psychiatric Disorder C97150 NICHD Neurological Development Terminology C97164 Childhood Disintegrative Disorder Childhood Disintegrative Disorder A pediatric disorder characterized by normal development for at least the first two years of life followed by a severe regression in language, social interaction, bowel or bladder control, and/or motor skills. The affected individual may also exhibit repetitive and stereotyped patterns of behavior similar to autism. A neurodevelopmental disorder that presents between the ages of two and ten, and is characterized by severe regression of communication, social interactions, bowel or bladder control, and/or motor skills that has previously developed normally. C92190 Pediatric Psychiatric Disorder C97179 Pervasive Developmental Disorder C97150 NICHD Neurological Development Terminology C35004 Childhood Schizophrenia Childhood Schizophrenia Schizophrenia occurring in childhood. C92190 Pediatric Psychiatric Disorder C97150 NICHD Neurological Development Terminology C27645 Conductive Hearing Loss Conductive Hearing Loss Hearing loss caused by impaired transmission of signals from the external auditory canal or middle ear to the cochlea. Hearing loss caused by impaired transmission of signals from the external auditory canal or middle ear to the cochlea. C35731 Hearing Loss C97150 NICHD Neurological Development Terminology C35107 Congenital Genitourinary Abnormality Congenital Genitourinary Abnormality Congenital Abnormality of the Genitourinary System An abnormality of the genitourinary system that is present at birth or detected in the neonatal period. C2849 Congenital Abnormality|Congenital Malformation C97150 NICHD Neurological Development Terminology C97172 Congenital Nervous System Disorder Congenital Nervous System Disorder Congenital Abnormality of the Nervous System An abnormality of the nervous system that is present at birth or detected in the neonatal period. C2849 Congenital Abnormality|Congenital Malformation C26835 Nervous System Disorder C97150 NICHD Neurological Development Terminology C34527 Demyelinating Disorder Demyelinating Disorder A broad group of disorders that affect the myelin sheaths that cover the neurons. Myelin sheathes cover neuronal axons in the central and peripheral nervous system and function to increase travelling impulse speeds. Disruption of this sheath impairs neuronal transmission and can result in disorders such as multiple sclerosis and Guillain-Barre syndrome, among others. C26835 Nervous System Disorder C97150 NICHD Neurological Development Terminology C92561 Developmental Coordination Disorder Developmental Coordination Disorder Developmental Dyspraxia A disorder characterized by an impairment in the development of an individual's motor coordination skills; this impairment in motor development is not due to a medical condition. A developmental disorder characterized by voluntary motor skill impairment. C89338 Neurodevelopmental Disorder C97150 NICHD Neurological Development Terminology C97165 Dyscalculia Dyscalculia A wide group of related learning disorders characterized by difficulties with mathematics and manipulating numbers; the difficulty with math may be caused or exacerbated by visuo-spatial or language processing difficulties. C89334 Learning Disorder C97150 NICHD Neurological Development Terminology C96410 Dyslexia Dyslexia A learning disorder characterized by an impairment in processing written words. Reading difficulties can include distortions, omissions or substitutions of characters. Oral and silent reading difficulties can include faulty and slow comprehension. C89334 Learning Disorder C97150 NICHD Neurological Development Terminology C89332 Eating Disorder Eating Disorder A broad group of psychological disorders with abnormal eating behaviors leading to physiological effects from overeating or insufficient food intake. C2893 Psychiatric Disorder C97150 NICHD Neurological Development Terminology C97166 Echolalia Echolalia A symptom of neurologic or psychiatric dysfunction in which the individual involuntarily and meaninglessly repeats a recently heard word, series of words, or a song. Involuntarily repeating of other peoples words. C97170 Central Auditory Processing Disorder C97150 NICHD Neurological Development Terminology C26920 Encephalopathy Encephalopathy A functional and/or structural disorder of the brain caused by diseases (e.g. liver disease, kidney disease), medications, chemicals, and injuries. Diffuse disease of the brain that alters function and/or structure of the brain and is characterized by an altered mental state. C96413 Brain Disorder C97150 NICHD Neurological Development Terminology C92622 Generalized Anxiety Disorder Generalized Anxiety Disorder An anxiety disorder characterized by excessive and difficult-to-control worry about a number of life situations. The worry is accompanied by restlessness, fatigue, inability to concentrate, irritability, muscle tension, and/or sleep disturbance and lasts for at least 6 months. C2878 Anxiety Disorder C97150 NICHD Neurological Development Terminology C35731 Hearing Loss Hearing Loss A partial or complete loss of hearing in one or both ears. It is classified as conductive, sensory, or central. Impaired ability to hear. C63711 Sensory Disorder C97150 NICHD Neurological Development Terminology C97250 Intellectual Disability Intellectual Disability Intellectual Disabilities A broad category of disorders characterized by an impairment to the intelligence an individual possesses. These impairments can result from trauma, birth, or disease and are not restricted to any particular age group. C96413 Brain Disorder C97150 NICHD Neurological Development Terminology C50896 Intraventricular Brain Hemorrhage Intraventricular Hemorrhage Bleeding into the brain's ventricles. C50438 Intracranial Hemorrhage C97150 NICHD Neurological Development Terminology C97155 Language Disorder Language Disorder A category of disorders characterized by an impairment in the development of an individual's language capabilities, which is in contrast to his/her non-verbal intellect. C92190 Pediatric Psychiatric Disorder C97150 NICHD Neurological Development Terminology C97175 Low Vision Low Vision Reduced ability to perceive visual stimuli. C35126 Vision Disorder C97150 NICHD Neurological Development Terminology C84392 Mental Retardation Mental Retardation A developmental disorder characterized by less than average intelligence and significant limitations in adaptive behavior with onset before the age of 18. A condition of arrested or incomplete development of the mind, which is especially characterized by impairment of skills manifested during the developmental period, which contribute to the overall level of intelligence, i.e. cognitive, language, motor, and social abilities. C92190 Pediatric Psychiatric Disorder C97150 NICHD Neurological Development Terminology C97177 Mixed Cerebral Palsy Mixed Cerebral Palsy A subtype of cerebral palsy characterized by both the tight muscle tone of spastic cerebral palsy and the writhing, involuntary muscle movements of athetoid cerebral palsy. A type of cerebral palsy characterized by both increased muscle tone and involuntary, purposeless writhing movements that affect the hands, feet, arms, and legs. C34460 Cerebral Palsy C97150 NICHD Neurological Development Terminology C26974 Mixed Hearing Loss Mixed Hearing Loss Hearing loss characterized by a combination of conductive and sensorineural hearing loss. It is caused by problems in both the inner ear and middle or outer ear. A combination of conductive and sensorineural hearing loss. C35731 Hearing Loss C97150 NICHD Neurological Development Terminology C26835 Nervous System Disorder Nervous System Disorder Neurologic Disorder A non-neoplastic or neoplastic disorder that affects the brain, spinal cord, or peripheral nerves. C2991 Disease or Disorder C97150 NICHD Neurological Development Terminology C88411 Obsessive Compulsive Disorder Obsessive Compulsive Disorder Obsessive-Compulsive Disorder A disorder characterized by the presence of persistent and recurrent irrational thoughts (obsessions), resulting in marked anxiety and repetitive excessive behaviors (compulsions) as a way to try to decrease that anxiety. C2878 Anxiety Disorder C97150 NICHD Neurological Development Terminology C97194 Panic Disorder with Agoraphobia Panic Disorder with Agoraphobia A disorder in which an individual experiences recurrent, unexpected panic attacks and persistent concern about having additional panic attacks. Agoraphobia is a component of this disorder. C2878 Anxiety Disorder C97150 NICHD Neurological Development Terminology C97193 Panic Disorder without Agoraphobia Panic Disorder without Agoraphobia A disorder in which an individual experiences recurrent, unexpected panic attacks and persistent concern about having additional panic attacks. Agoraphobia is not a component of this disorder. C2878 Anxiety Disorder C97150 NICHD Neurological Development Terminology C92190 Pediatric Psychiatric Disorder Pediatric Psychiatric Disorder Childhood Mental Disorder A category of psychiatric disorders which includes disorders most commonly identified in infancy, childhood, or adolescence. C89328 Pediatric Disorder C97150 NICHD Neurological Development Terminology C97179 Pervasive Developmental Disorder Pervasive Developmental Disorder A category of developmental disorders characterized by impaired communication and socialization skills. The impairments are incongruent with the individual's developmental level or mental age. These disorders can be associated with general medical or genetic conditions. C96412 Brain Development Abnormality C97150 NICHD Neurological Development Terminology C3389 Post-Traumatic Stress Disorder Post-Traumatic Stress Disorder An anxiety disorder precipitated by an experience of intense fear or horror while exposed to a traumatic (especially life-threatening) event. The disorder is characterized by intrusive recurring thoughts or images of the traumatic event; avoidance of anything associated with the event; a state of hyperarousal and diminished emotional responsiveness. These symptoms are present for at least one month and the disorder is usually long-term. C2878 Anxiety Disorder C97150 NICHD Neurological Development Terminology C75488 Rett Syndrome Rett Syndrome A progressive neurologic disorder caused by mutations in the MECP2 gene on chromosome X. It almost exclusively affects girls. It is characterized by language and learning difficulties, poor communication skills, and repetitive hand motions. Other signs and symptoms include microcephaly, scoliosis, breathing abnormalities, and sleep disturbances. C97179 Pervasive Developmental Disorder C97150 NICHD Neurological Development Terminology C2962 Seizure Seizure Sudden, involuntary skeletal muscular contractions of cerebral or brain stem origin. A paroxysmal surge of electrical activity in the brain that may result in physical or behavioral changes. C87124 Central Nervous System Signs and Symptoms C97150 NICHD Neurological Development Terminology C3020 Seizure Disorder Seizure Disorder Epilepsy A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions. A neurological disorder characterized by recurring seizures. C96413 Brain Disorder C97150 NICHD Neurological Development Terminology C92569 Selective Mutism Selective Mutism A persistent failure to speak in certain social situations (i.e., school) where speaking is expected, despite speaking in other situations. C2878 Anxiety Disorder C97150 NICHD Neurological Development Terminology C26739 Sensorineural Hearing Loss Sensorineural Hearing Loss Hearing loss resulting from damage to the cochlea, auditory nerve and/or brainstem. A type of hearing impairment due to abnormal functioning of the hair cells of the cochlea, the vestibulocochlear nerve, or the central processing centers of the brain.|Hearing loss resulting from damage to the cochlea, auditory nerve and/or brainstem. C35731 Hearing Loss C97150 NICHD Neurological Development Terminology C63711 Sensory Disorder Sensory Disorder An interruption or alteration in the sensory activity or functions of the nervous system. C2991 Disease or Disorder C97150 NICHD Neurological Development Terminology C35014 Separation Anxiety Disorder Separation Anxiety Disorder An anxiety disorder characterized by recurrent excessive distress due to fear of separation from the home or from major attachment figures; the distress is developmentally inappropriate and causes impairment in social, academic, or other areas of functioning. C92190 Pediatric Psychiatric Disorder C97150 NICHD Neurological Development Terminology C34927 Social Anxiety Disorder Social Anxiety Disorder An anxiety disorder characterized by an intense, irrational fear of one or more social or performance situations in which the individual believes that he or she will be scrutinized by others. Exposure to social situations immediately provokes an anxiety response. In adults, the social phobia is recognized as excessive or unreasonable. C2878 Anxiety Disorder C97150 NICHD Neurological Development Terminology C35284 Specific Phobia Specific Phobia An anxiety disorder characterized by an intense, irrational fear cued by the presence or anticipation of a specific object or situation. Exposure to the phobic stimulus immediately provokes an anxiety response. In adults, the specific phobia is recognized as excessive or unreasonable. C2878 Anxiety Disorder C97150 NICHD Neurological Development Terminology C5041 Speech Disorder Speech Disorder A term referring to disorders characterized by the disruption of normal speech. It includes stuttering, lisps, dysarthria and voice disorders. C26835 Nervous System Disorder C97150 NICHD Neurological Development Terminology C35078 Tourette Syndrome Tourette Syndrome Tourette's Syndrome A neurologic disorder caused by defective metabolism of the neurotransmitters in the brain. It is characterized by repeated involuntary movements (motor tics) and uncontrollable vocal sounds (vocal tics). The symptoms are usually manifested before the age of eighteen. A neurological disorder presenting in childhood that is characterized by both motor and phonic tics that occur daily or nearly daily for at least a year and are not attributed to an identifiable cause. C96412 Brain Development Abnormality C116757 Movement Disorders C97150 NICHD Neurological Development Terminology C35126 Vision Disorder Vision Disorder Visual impairments limiting one or more of the basic functions of the eye: visual acuity, dark adaptation, color vision, or peripheral vision. These may result from eye diseases, optic nerve diseases, visual pathway diseases, occipital lobe diseases, ocular motility disorders' and other conditions. C63711 Sensory Disorder C97150 NICHD Neurological Development Terminology C35275 Visual Cortex Disorder Visual Cortex Disorder Cortical Visual Impairment A vision disorder that results from damage of the part of the cerebral cortex that is involved in the processing of visual information. C35126 Vision Disorder C97150 NICHD Neurological Development Terminology C3368 Digestive System Signs and Symptoms Signs and symptoms associated with disturbances within the digestive system, which includes the stomach, intestines and all associated organs that aid in digestion. C100104 Sign or Symptom C89506 NICHD Newborn Screening Terminology C12664 Abdomen Abdomen The portion of the body that lies between the thorax and the pelvis. C32221 Body Part C89506 NICHD Newborn Screening Terminology C25407 Address Address A standardized representation of the location of a person, business, building, or organization. C16495 Demographics C89506 NICHD Newborn Screening Terminology C81229 Alcohol Use History Alcohol Use History A description of an individual's current and past experience with alcoholic beverage consumption. C18772 Personal Medical History C89506 NICHD Newborn Screening Terminology C15181 Anesthesia Procedure Anesthesia Procedure Treatment with a pharmacological substance that produces a loss of feeling. C25218 Intervention or Procedure C89506 NICHD Newborn Screening Terminology C32078 Ankle Joint Ankle Joint A gliding joint between the distal ends of the tibia and fibula and the proximal end of the talus. C32221 Body Part C89506 NICHD Newborn Screening Terminology C73437 Apgar Score Apgar Score APGAR Score The numerical sum between zero and ten that is computed from individual values of zero to two that are assigned to five different areas of interest in newborn screenings. These areas are breathing, muscle tone, pulse rate, reflex irritability and skin color. The numerical sum between zero and ten that is computed from individual values of zero to two that are assigned to five different areas of interest in newborn screenings. These areas are breathing, muscle tone, pulse rate, reflex irritability and skin color. C118807 C89506 NICHD Newborn Screening Terminology C81230 Apgar Test Apgar Test APGAR Test A test devised by Dr. Virginia Apgar to assess the overall health of a newborn upon birth. The test is administered at one and five minutes after birth and allows for the assignation of numerical values between zero and two for specific observations regarding skin color, pulse rate, reflex irritability, muscle tone and breathing. C84749 Newborn Examination C89506 NICHD Newborn Screening Terminology C32141 Arm Arm The portion of the upper extremity between the shoulder and the elbow. For clinical purposes this term is also used to refer to the whole superior limb. C32221 Body Part C89506 NICHD Newborn Screening Terminology C90496 Arm Recoil Test Arm Recoil Test Arm Recoil Measurement A test commonly administered to assess the physiologic response to extending the arms as straight as possible alongside the body when lying down. C84749 Newborn Examination C89506 NICHD Newborn Screening Terminology C81231 Attending Health Care Provider Attending Health Care Provider The individual assigned to be the primary care manager overseeing a patient's medical care during an episode of hospitalization. C25190 Person C89506 NICHD Newborn Screening Terminology C38036 Audiometric Test Audiometric Test Testing conducted utilizing a manual or microprocessor audiometer to test for hearing loss. C84749 Newborn Examination C89506 NICHD Newborn Screening Terminology C2890 Bacterial Infection Bacterial Disease An acute infectious disorder caused by gram positive or gram negative bacteria. Representative examples include pneumococcal, streptococcal, salmonella and meningeal infections. C26726 Infectious Disease C89506 NICHD Newborn Screening Terminology C89512 Barlow's Maneuver Barlow's Maneuver Useful in assessing for developmental dysplasia of the hip, this test is performed when the thigh is pushed posteriorly and the hip is adducted. Should the hip become dislocated by this movement, the result is considered positive. C84749 Newborn Examination C89506 NICHD Newborn Screening Terminology C61454 Basilar Rales Basilar Rales Abnormal breath sounds (crackles) heard on auscultation only in the bases of the lungs. They indicate inflammation, fluid, or infection in the air sacs of the lung. C100104 Sign or Symptom C89506 NICHD Newborn Screening Terminology C81232 Bayley Scale of Infant Development I Bayley Scale of Infant Development I Bayley Scales of Infant Development The first edition of a standardized series of measurements that assesses the cognitive, motor, and behavioral development in infants and babies from one to twenty-four months of age. C81314 Newborn Behavioral Examination C89506 NICHD Newborn Screening Terminology C81234 Behavioral Assessment Behavioral Assessment Assessment of individual responses to age appropriate stimuli. C25214 Evaluation Procedure C89506 NICHD Newborn Screening Terminology C81233 Behavioral Development Behavioral Development The evolution of actions, including reactions and responses to the environment, over an individual's lifespan. C17770 Maturation C89506 NICHD Newborn Screening Terminology C81235 Behavioral Rating Scale Behavioral Rating Scale A range of values designed to quantify the qualitative responses of an individual to a set of challenges. C81314 Newborn Behavioral Examination C89506 NICHD Newborn Screening Terminology C81236 Birth Complication Birth Complication The development of a problematic medical situation that occurs concurrently with the birth of a neonate. C2959 Complication C89506 NICHD Newborn Screening Terminology C68615 Birth Date Birth Date The calendar date on which a person was born. C25164 Date C89506 NICHD Newborn Screening Terminology C81237 Birth Facility Birth Facility The facility which provides a setting with provisions for monitoring and delivering babies. C16495 Demographics C89506 NICHD Newborn Screening Terminology C81296 Birth Time Birth Time The hour, minute, and/or second at which birth occurs. C25207 Time C89506 NICHD Newborn Screening Terminology C76325 Birth Weight Birth Weight The first weight of a newborn obtained after birth. A measured weight of a newborn obtained immediately or shortly after birth. C81328 Body Weight C89506 NICHD Newborn Screening Terminology C54706 Blood Pressure Blood Pressure The pressure of the circulating blood against the walls of the blood vessels. C25447 Characteristic C89506 NICHD Newborn Screening Terminology C81304 Blood Product Blood Product Any natural or synthetic composition that replicates the structure or function of a native component of blood. C13236 Body Fluid or Substance C89506 NICHD Newborn Screening Terminology C15192 Blood Transfusion Blood Transfusion The injection of whole blood or a blood component directly into the bloodstream. C49236 Therapeutic Procedure C89506 NICHD Newborn Screening Terminology C13236 Body Fluid or Substance Body Fluid or Substance Material produced by living organisms; it can be a necessary constituent of, or product of an organismal process. C45306 Substance C89506 NICHD Newborn Screening Terminology C32221 Body Part Body Part Any part of an organism. C12219 Anatomic Structure, System, or Substance C89506 NICHD Newborn Screening Terminology C81328 Body Weight Body Weight The weight of a subject. C25447 Characteristic C89506 NICHD Newborn Screening Terminology C81305 Bottle Feeding Bottle Feeding Provision of liquid nutrition via a closed container system with a rubber like mouthpiece resembling a nipple. Delivery of enteral nutrition by a bottle. C81267 Feeding Method C89506 NICHD Newborn Screening Terminology C81238 Brazelton Neonatal Behavioral Assessment Scale Brazelton Neonatal Behavioral Assessment Scale An assessment tool created by Dr. T. Berry Brazelton and his colleagues to assist caregivers in determining developmental strengths and weaknesses in infants from birth to the age of two months. C81314 Newborn Behavioral Examination C89506 NICHD Newborn Screening Terminology C25596 Breast Feeding Breast Feeding The nursing of an infant at the mother's breast. The nursing of an infant at the mother's breast. C16326 Behavior C89506 NICHD Newborn Screening Terminology C13257 Breast Milk Breast Milk Milk produced by female mammals for the purpose of feeding their young. C13236 Body Fluid or Substance C89506 NICHD Newborn Screening Terminology C81306 Breathing Effort Score Breathing Effort Score A component of the Apgar score, it is the numerical value assigned to the assessment of breathing effort by a neonate. 0 = no spontaneous respirations; 1 = slow or irregular respirations or a weak cry; 2 = strong, consistent respirations with a robust cry. A component of the Apgar score, it is the numerical value assigned to the assessment of the newborn's breathing effort. 0 = no spontaneous respirations; 1 = slow or irregular respirations or a weak cry; 2 = strong, consistent respirations with a robust cry. C118807 C89506 NICHD Newborn Screening Terminology C87067 Caput Succedaneum Caput Succedaneum A diffuse swelling of the scalp in a newborn, usually caused by the trauma of the scalp pushing through a narrowed cervix during birth. The swelling may extend across the midline of the scalp and may exhibit discoloration or bruising. A diffuse swelling of the scalp in a newborn, usually caused by the trauma of the scalp pushing through a narrowed cervix during birth. The swelling may extend across the midline of the scalp and may exhibit discoloration or bruising. C81236 Birth Complication C89506 NICHD Newborn Screening Terminology C2931 Cardiovascular Disorder Cardiovascular Disorder A non-neoplastic or neoplastic disorder affecting the heart or the vessels (arteries, veins and lymph vessels). Representative examples of non-neoplastic cardiovascular disorders are endocarditis and hypertension. Representative examples of neoplastic cardiovascular disorders are endocardial myxoma and angiosarcoma. C2991 Disease or Disorder C89506 NICHD Newborn Screening Terminology C81239 Cause of Death Cause of Death The circumstance or condition that results in the death of a living being. C3367 Finding C89506 NICHD Newborn Screening Terminology C81240 Cellular Telephone Number Cellular Telephone Number The sequence of numbers or characters, that when dialed, connects to a particular cellular telephone. C40978 Telephone Number C89506 NICHD Newborn Screening Terminology C49668 Centimeter Centimeter A basic unit of length in the former CGS version of metric system, equal to one hundredth of a meter or approximately 0.393 700 787 inch. C25709 Unit of Measure C89506 NICHD Newborn Screening Terminology C87124 Central Nervous System Signs and Symptoms Central Nervous System Signs and Symptoms Signs and symptoms associated with disturbances within the central nervous system, which includes the brain, spinal cord and meninges. C100104 Sign or Symptom C89506 NICHD Newborn Screening Terminology C50484 Cephalohematoma Cephalohematoma Cephalhematoma A subperiosteal hemorrhage limited to the surface of one cranial bone, a usually benign condition seen in the newborn as a result of bone trauma. A subperiosteal hemorrhage limited to the surface of one cranial bone. It is seen in the newborn and often related to the birthing process. C81236 Birth Complication C92719 Fetal Disorder C89506 NICHD Newborn Screening Terminology C46088 Cesarean Section Cesarean Section C-Section|Caesarean Section Surgical delivery of one or more intrauterine fetuses though an abdominal incision. Surgical delivery of one or more intrauterine fetuses though an abdominal incision. C81179 Delivery Procedure C90491 C89506 NICHD Newborn Screening Terminology C25447 Characteristic Characteristic The distinguishing qualities or prominent aspect of a person, object, action, process, or substance. C20189 Property or Attribute C89506 NICHD Newborn Screening Terminology C25160 City City A large and densely populated urban area; a city specified in an address. C16495 Demographics C89506 NICHD Newborn Screening Terminology C87175 Cleft Lip Cleft Lip A congenital abnormality consisting of one or more clefts (splits) in the upper lip, which may be accompanied by a cleft palate; it is the result of the failure of the embryonic parts of the lip to fuse. C97171 Congenital Gastrointestinal Disorder C89506 NICHD Newborn Screening Terminology C87069 Cleft Palate Cleft Palate A congenital abnormality consisting of a fissure in the midline of the hard and/or soft palate; it is the result of the failure of the two sides of the palate to fuse during embryonic development. C97171 Congenital Gastrointestinal Disorder C89506 NICHD Newborn Screening Terminology C34484 Clonus Clonus A form of involuntary muscular movement characterized by alternating contractions and relaxation in rapid succession. In the context of reflex testing, the ability to elicit clonus indicates injury to the nerve tracts above the point at which the reflex was initiated. C100104 Sign or Symptom C89506 NICHD Newborn Screening Terminology C34491 Clubbing of Fingers Clubbing of Fingers An abnormal enlargement of the terminal phalanges accompanied by increased length-wise curvature of the nails, giving the digits a club-like appearance. Clubbing has been noted with a wide variety of conditions, including pulmonary and cardiac diseases, liver disorders, and disorders of the gastrointestinal tract. C100104 Sign or Symptom C89506 NICHD Newborn Screening Terminology C84641 Clubfoot Clubfoot The most common congenital deformation of the foot, occurring in 1 of 1,000 live births. The most common form is talipes equinovarus, where the deformed foot is turned downward and inward sharply. A congenital malformation involving one or both feet, in which the affected foot is rotated inward and downward. C84978 Osteochondrodysplasia|Skeletal Dysplasia C89506 NICHD Newborn Screening Terminology C62736 Cognitive Assessment Cognitive Assessment The examination of the cognitive capacities or deficits of an individual through the application of tests that probe that individual's ability to perform various mental activities such as perception, learning, and reasoning. C81313 Neurologic Examination C89506 NICHD Newborn Screening Terminology C81241 Cognitive Development Cognitive Development The evolution of an individual's problem solving skills, memory, language development, and ability to process information about their environment. C17770 Maturation C89506 NICHD Newborn Screening Terminology C81286 Collection Date Collection Date The date on which the sample or data was collected. C25164 Date C89506 NICHD Newborn Screening Terminology C81287 Collection Time Collection Time The hour, minute, and/or second at which the sample or data was collected. C25207 Time C89506 NICHD Newborn Screening Terminology C2849 Congenital Abnormality Congenital Abnormality Any abnormality, anatomical or biochemical, evident at birth or during the neonatal period. A morphologic defect of an organ, part of an organ, or larger region of the body that results from an intrinsically abnormal developmental process during gestation. C36287 C89328 Pediatric Disorder C89506 NICHD Newborn Screening Terminology C87077 Congenital Ankyloblepharon Congenital Ankyloblepharon Fused Eyelid A congenital abnormality in which the margins of the upper and lower eyelids are fused together by bands of tissue. A finding in extremely premature newborns in which the normal epithelial adhesions connecting the upper and lower eyelids have not yet degraded. C99208 Eye Finding C89506 NICHD Newborn Screening Terminology C26734 Congenital Hypothyroidism Congenital Hypothyroidism A deficiency of thyroid hormone present at birth. The etiology can be genetic or environmental, or a combination of both; treatment is based on severity and causality. C34816 Congenital Metabolic Disorder C89506 NICHD Newborn Screening Terminology C34816 Congenital Metabolic Disorder Congenital Metabolic Disorder A group of disorders present at birth that involve genetic defects leading to disturbances in carbohydrate, lipid, lysosomal storage or amino acid metabolism in the body. C3235 Metabolic Disease C97151 Congenital Systemic Disorder C89506 NICHD Newborn Screening Terminology C89337 Congenital Musculoskeletal Defect Congenital Musculoskeletal Defect Congenital Abnormality of the Musculoskeletal System An abnormality of the musculoskeletal system that is present at birth or detected in the neonatal period. C2849 Congenital Abnormality|Congenital Malformation C107377 Musculoskeletal System Disorder C89506 NICHD Newborn Screening Terminology C390 Contrast Agent Contrast Agent Substances administered during imaging procedures that allows delineation of internal structures. Contrast agents appear opaque due to the difference in absorption of X-rays or other electromagnetic waves and surrounding tissue. C1909 Pharmacologic Substance C89506 NICHD Newborn Screening Terminology C81242 Crown to Rump Length Measurement Crown to Rump Length Measurement A measurement from the high prominence of the head to the low prominence of the buttocks of a fetus or embryo during ultrasound. This measurement is useful in determining gestational age. A measurement from the high prominence of the head to the low prominence of the buttocks of a fetus or embryo during ultrasound. C81253 Gestational Age|Gestational Weeks Assessment C89506 NICHD Newborn Screening Terminology C26737 Cyanosis Cyanosis A bluish or purplish discoloration of the skin and mucous membranes resulting from a reduced amount of oxygenated hemoglobin in the blood. C100104 Sign or Symptom C89506 NICHD Newborn Screening Terminology C87065 Cyanotic Body Cyanotic Body Blue- or purplish-colored body; this is caused by excessive amounts of deoxygenated hemoglobin in the skin vessels of the body. C26737 Cyanosis C89506 NICHD Newborn Screening Terminology C87066 Cyanotic Limbs Cyanotic Limbs Blue- or purplish-colored limbs; this is caused by excessive amounts of deoxygenated hemoglobin in the skin vessels of the limbs. C26737 Cyanosis C89506 NICHD Newborn Screening Terminology C3724 Cystic Hygroma Cystic Hygroma Cystic Lymphangioma A benign lymphatic neoplasm usually arising from the neck and characterized by cystic dilation of the lymphatic vessels. C2978 Cyst C3262 Neoplasm C89506 NICHD Newborn Screening Terminology C25164 Date Date The particular day, month and year an event has happened or will happen. C21514 Temporal Qualifier C89506 NICHD Newborn Screening Terminology C27644 Deafness Deafness An inherited or acquired condition characterized by the inability to hear in one or both ears. Inability to hear. C35731 Hearing Loss C89506 NICHD Newborn Screening Terminology C81244 Deceased Sibling Deceased Sibling The historical fact that a legal or consanguineous brother or sister has died. C90491 C89506 NICHD Newborn Screening Terminology C81179 Delivery Procedure Delivery Procedure Description of the method by which a fetus is delivered. C89340 C89506 NICHD Newborn Screening Terminology C16495 Demographics Demographics The statistical characterization of human populations or segments of human populations (e.g., characterization by age, sex, race, or income). C20189 Property or Attribute C89506 NICHD Newborn Screening Terminology C81245 Denver Development Screening Test Denver Development Screening Test A test developed at the University of Colorado Medical Center to assess the developmental status of infants and children from birth to six years of age. C84749 Newborn Examination C89506 NICHD Newborn Screening Terminology C9011 Dermoid Cyst Dermoid Cyst A mature teratoma characterized by the presence of a cyst which is lined by mature tissue resembling the epidermis and the epidermal appendages. It occurs in the ovary, testis, and extragonadal sites including central nervous system and skin. A benign hamartomatous tumor that possesses various epidermal derivatives and is due to sequestration of skin along the lines of embryonic closure. In neonates, it is most commonly congenital and located in the subcutaneous tissues of the head, neck, or trunk. C2978 Cyst C89506 NICHD Newborn Screening Terminology C84669 Dextrocardia Dextrocardia A rare congenital abnormality in which the heart is located in the right side of the chest. It is associated with other congenital heart defects. C95834 Congenital Heart Disease C89506 NICHD Newborn Screening Terminology C15220 Diagnosis Diagnosis The investigation, analysis and recognition of the presence and nature of disease, condition, or injury from expressed signs and symptoms; also, the scientific determination of any kind; the concise results of such an investigation. C3367 Finding C89506 NICHD Newborn Screening Terminology C34687 Diaphragmatic Hernia Diaphragmatic Hernia A congenital or acquired weakness or opening in the diaphragm which allows abdominal contents to protrude into the chest cavity; congenital diaphragmatic hernias are caused when the embryonic diaphragm fails to fuse. C34685 Hernia C89506 NICHD Newborn Screening Terminology C81273 Doctor's Information Doctor's Information A collection of information about a patient's doctor. C18772 Personal Medical History C89506 NICHD Newborn Screening Terminology C81246 Drug Use History Drug Use History A description of an individual's current and past use and/or abuse of drugs and chemicals. This includes prescription medication, illicit drugs and recreational substances. C18772 Personal Medical History C89506 NICHD Newborn Screening Terminology C81282 Dubowitz Score Dubowitz Score Ballard/Dubowitz Score The numerical value that represents a clinical assessment of neurological and physical criteria, performed between birth and five days of age, to determine an infant's gestational age and maturity. C118807 C89506 NICHD Newborn Screening Terminology C12394 Ear Ear A sense organ needed for the detection of sound and for establishing balance. The outer ear consists of the auricle, the ear canal as well as the tympanic membrane. The middle ear is made up of an air-filled cavity behind the tympanic membrane that contains the ossicles (malleus, incus and stapes). The inner ear is made up of the cochlea needed for hearing and the vestibular apparatus required for balance. C32221 Body Part C89506 NICHD Newborn Screening Terminology C87071 Ear Dimple Ear Dimple A pit or dimple in front of the ear of a newborn is a common finding; rarely, such a dimple may get infected, which will be manifested with redness and swelling and will require medical attention. C100104 Sign or Symptom C89506 NICHD Newborn Screening Terminology C87167 Eclampsia Eclampsia A potentially life-threatening pregnancy-related disorder characterized by tonic-clonic seizures in association with hypertension after the twentieth week of gestation and up to six weeks postpartum and in the absence of other potential causes of seizures. A potentially life-threatening pregnancy-related disorder characterized by tonic-clonic seizures in association with hypertension after the twentieth week of gestation and up to six weeks postpartum and in the absence of other potential causes of seizures. C35169 Pregnancy Disorder C89506 NICHD Newborn Screening Terminology C17953 Education Level Education Level An indication of the years of schooling completed in graded public, private, or parochial schools, and in colleges, universities, or professional schools. C16495 Demographics C89506 NICHD Newborn Screening Terminology C32497 Elbow Joint Elbow Joint A type of hinge joint located between the forearm and upper arm. C32221 Body Part C89506 NICHD Newborn Screening Terminology C81326 Elevated Test Result Elevated Test Result A result of a test that is higher than a previous value or a normal range of values. C36292 Laboratory Test Result C89506 NICHD Newborn Screening Terminology C84687 Encephalocele Encephalocele A congenital neural tube closure defect resulting in the protrusion of the brain through a skull opening. When the protrusion includes the meninges, the term encephalomeningocele is used. C84923 Neural Tube Defect C89506 NICHD Newborn Screening Terminology C15642 Epidural Block Epidural Block An anesthetic procedure that involves administering pharmaceutical agents into the epidural space of the spinal canal. Frequently administered agents include local anesthetics and analgesics. C64381 Regional Anesthesia Procedure C89506 NICHD Newborn Screening Terminology C87072 Esophageal Atresia Esophageal Atresia A congenital abnormality of the esophagus in which the upper esophagus ends as a blind pouch and does not connect with the lower esophagus; it is often accompanied by a tracheoesophageal fistula. Signs and symptoms in a newborn with this abnormality include excessive salivation, choking, coughing, and the development of cyanosis and respiratory distress when fed. C97171 Congenital Gastrointestinal Disorder C89506 NICHD Newborn Screening Terminology C16564 Ethnic Group Ethnic Group A social group characterized by a distinctive social and cultural tradition that is maintained from generation to generation. Members share a common history and origin and a sense of identification with the group. They have similar and distinctive features in their lifestyle habits and shared experiences. They often have a common genetic heritage which may be reflected in their experience of health and disease. C16495 Demographics C89506 NICHD Newborn Screening Terminology C87073 Excessive Sucking Excessive Sucking A symptom of gastrointestinal dysfunction seen in neonates who have been exposed to drugs during pregnancy; often accompanied by excessive sucking of fists, fingers and thumbs. C100104 Sign or Symptom C89506 NICHD Newborn Screening Terminology C34599 Excoriation Excoriation Self-inflicted tearing or wearing off of skin. Self-inflicted tearing or wearing off of skin. C36281 Integumentary System Finding C100104 Sign or Symptom C89506 NICHD Newborn Screening Terminology C81247 Expected Date of Confinement Expected Date of Confinement The best estimated due date is determined by: last menstrual period (LMP) if confirmed by early ultrasound or no ultrasound performed, or early ultrasound if no known LMP or the ultrasound is not consistent with LMP, or known date of fertilization (e.g. Assisted Reproductive Technology (ART), Intrauterine Insemination (IUI)). Notes: 1. Ultrasound margin of error and "early" to be defined by SMFM/ACOG/NICHD workshop. 2. Pregnancy should not be re-dated by a later ultrasound after a best obstetrical estimate of EDD has been established. (adapted from reVITALize) The best estimated due date is determined by: last menstrual period (LMP) if confirmed by early ultrasound or no ultrasound performed, or early ultrasound if no known LMP or the ultrasound is not consistent with LMP, or known date of fertilization (e.g. Assisted Reproductive Technology (ART), Intrauterine Insemination (IUI)). C25164 Date C89506 NICHD Newborn Screening Terminology C12401 Eye Eye The organ of sight or vision. C32221 Body Part C89506 NICHD Newborn Screening Terminology C87074 Eye Prophylaxis Eye Prophylaxis The practice of placing antibiotic eye drops or ointment in a neonate's eyes after birth. C49236 Therapeutic Procedure C89506 NICHD Newborn Screening Terminology C81267 Feeding Method Feeding Method A description of the technique for the manner in which a subject is administered food. The technique for delivery of enteral nutrition. C3367 Finding C89506 NICHD Newborn Screening Terminology C16576 Female Female A person who belongs to the sex that normally produces ova. The term is used to indicate biological sex distinctions, or cultural gender role distinctions, or both. C28421 Sex C89506 NICHD Newborn Screening Terminology C13235 Fetus Fetus An unborn or unhatched vertebrate in the later stages of development showing the main recognizable features of the mature being. C25190 Person C89506 NICHD Newborn Screening Terminology C3367 Finding Finding Clinical, laboratory or molecular evidence, or absence of evidence of disease. C89505 Prenatal and Pediatric Terminology C89506 NICHD Newborn Screening Terminology C89343 Finnegan Score Measurement Finnegan Score Measurement A tool to evaluate neonatal abstinence syndrome (NAS), that measures the degree to which a neonate is experiencing symptoms of withdrawal due to maternal substance abuse. C89515 Neonatal Abstinence Syndrome Assessment C89506 NICHD Newborn Screening Terminology C81272 First Feeding First Feeding The first time that a neonate is provided nutrition. C25207 Time C89506 NICHD Newborn Screening Terminology C81228 Five Minutes After Birth Five Minutes After Birth The actual time that is five minutes after the birth of a fetus. This period is most commonly referenced during the administration of the Apgar test. C25207 Time C89506 NICHD Newborn Screening Terminology C32621 Fontanelle Fontanelle The four gaps in the skull of a neonate or fetus where the sutures converge. The bulging or depression of the membranous soft spots can be indicative of intracranial fluid buildup or systemic dehydration. C32221 Body Part C89506 NICHD Newborn Screening Terminology C32622 Foot Foot The structure found below the ankle joint required for locomotion. C32221 Body Part C89506 NICHD Newborn Screening Terminology C81248 Forceps Delivery Forceps Delivery Application of forceps to the fetal head to facilitate vaginal birth. Application of forceps to the fetal head to facilitate vaginal birth. C81301 Vaginal Assisted Delivery C89506 NICHD Newborn Screening Terminology C87076 Frenulum Frenulum A small fold of tissue that limits the movements of an organ or body part; for example, the lingual frenulum connects the tongue to the floor of the mouth and restrains its movement. C32221 Body Part C89506 NICHD Newborn Screening Terminology C81308 Galactose Measurement Galactose Measurement The measurement of the amount of galactose in a biologic specimen. C49286 Hematology Test C89506 NICHD Newborn Screening Terminology C81251 Galactose-1-Phosphate Uridyltransferase Measurement Galactose-1-Phosphate Uridyltransferase Measurement The measurement of the galactose-1-phosphate uridyltransferase in a biologic specimen. C25294 Laboratory Procedure C89506 NICHD Newborn Screening Terminology C90497 Galeazzi Test Galeazzi Test An assessment for developmental dysplasia of the hip or a leg-length discrepancy, the patient is placed in a supine position and the ankles are brought to the buttocks with the hips and knees flexed. The result is considered positive when the knees are at different heights. C84749 Newborn Examination C89506 NICHD Newborn Screening Terminology C64380 General Anesthesia Procedure General Anesthesia Procedure Actions that render a patient unconscious for the purpose of performing a diagnostic or interventional procedure. C15181 Anesthesia Procedure C89506 NICHD Newborn Screening Terminology C87079 General Appearance General Appearance The result of observation and overall assessment of a subject's outward aspect including appearance and movements; for example, in a human newborn general appearance includes skin color and tone, range of motion, and spontaneous movements. C25447 Characteristic C89506 NICHD Newborn Screening Terminology C15709 Genetic Testing Genetic Testing The process of isolating and testing the DNA of an embryo or a person to detect the presence of genetic alterations or defects that may predispose to the future development of a disease or disorder. C25294 Laboratory Procedure C89506 NICHD Newborn Screening Terminology C25177 Genitalia Genitalia The external sex organs. C32221 Body Part C89506 NICHD Newborn Screening Terminology C81252 Gesell Developmental Schedule Gesell Developmental Schedule A scale used as an instrument to assess a child's motor and language development, as well as personal-social and adaptive behaviors. C81314 Newborn Behavioral Examination C89506 NICHD Newborn Screening Terminology C81253 Gestational Weeks Assessment Gestational Weeks Assessment Gestational age (written with both weeks and days, e.g. 39 weeks and 0 days) is calculated using the best obstetrical estimated due date (EDD) based on the following formula: Gestational Age = (280 - (EDD - Reference Date))/ 7. Note: Reference Date is the date on which you are trying to determine gestational age. (reVITALize) Gestational age (written with both weeks and days, e.g. 39 weeks and 0 days) is calculated using the best obstetrical estimated due date (EDD) based on the following formula: Gestational Age = (280 - (EDD - Reference Date))/ 7. Note: Reference Date is the date on which you are trying to determine gestational age. [verbatim from reVITALize] C89335 Life Stage C90341 Pediatric Intervention or Procedure C89506 NICHD Newborn Screening Terminology C26785 Goiter Goiter Enlargement of the thyroid gland usually caused by lack of iodine in the diet, hyperthyroidism, or thyroid nodules. Symptoms include difficulty in breathing and swallowing. C3009 Endocrine System Disorder C26836 Nutritional Disorder C89506 NICHD Newborn Screening Terminology C48155 Gram Gram The metric unit of mass equal to one thousandth of a kilogram. One gram equals approximately 15.432 grains or 0.035 273 966 ounce. C25709 Unit of Measure C89506 NICHD Newborn Screening Terminology C81254 Grasp Reflex Grasp Reflex An involuntary, primal response in the neonate to grasp the fingers when their palm is touched. This reflex is present until six months of age. An involuntary response in the neonate to grasp the fingers when the palm is touched, that disappears by 4-6 months of age. C81181 Infant Reflex C89506 NICHD Newborn Screening Terminology C87168 Group B Streptococcal Infection Group B Streptococcal Infection Group B Streptococcus, also known as Streptococcus agalactiae, colonizes the vaginal and gastrointestinal tracts of up to 45% of healthy women and may infect neonates in utero or during delivery, causing neonatal sepsis in 1-2% of colonized neonates. GBS infection may also occur in nonpregnant (particularly elderly) adults with underlying medical conditions, presenting as urinary tract infection, pneumonia, or soft-tissue infection. Infection of an infant from birth to three months caused by Group B Streptococcus (Streptococcus agalactiae) from a colonized mother. Invasive infections may include sepsis, meningitis, and pneumonia. C2890 Bacterial Disease C89506 NICHD Newborn Screening Terminology C32712 Hand Hand The distal portion of the upper extremity. It consists of the carpus, metacarpus, and digits. C32221 Body Part C89506 NICHD Newborn Screening Terminology C12419 Head Head The anterior and superior part of a human bearing the mouth, the brain and sensory organs. C32221 Body Part C89506 NICHD Newborn Screening Terminology C81255 Head Circumference Head Circumference A circumferential measurement of the head at the widest point, which is traditionally above the eyebrows. The widest measurement of the head, when it is measured at its occipitofrontal circumference. C25334 Length C89506 NICHD Newborn Screening Terminology C25178 Health Health Refers to a person's state of physical, mental and social well-being; usually it refers specifically to the state of being in good health, a state of complete physical, mental and social well-being, and does not consist only of the absence of disease or infirmity. In any organism health constitutes a form of homeostasis with inputs and outputs of energy and mass in approximate equilibrium allowing for growth and continued survival. In humans, a subjective feeling of well-being coming from somatic and cognitive perceptions is considered an essential component of health. C92722 Qualitative Concept C89506 NICHD Newborn Screening Terminology C84480 Heart Murmur Heart Murmur A periodic humming or blowing sound heard on auscultation of the heart that can indicate the presence of cardiac disease; murmurs are the result of vibrations caused by the turbulent flow of blood in the heart or great vessels. Murmurs are characterized according to the area of generation (mitral, aortic, tricuspid, or pulmonary) and according to the period of the cycle (systolic or diastolic). C35552 Cardiovascular System Finding C89506 NICHD Newborn Screening Terminology C49677 Heart Rate Heart Rate The number of heartbeats per unit of time, usually expressed as beats per minute. C35552 Cardiovascular System Finding C89506 NICHD Newborn Screening Terminology C81309 Heart Rate Score Heart Rate Score A component of the Apgar score, it is the numerical value assigned to an assessment of the circulatory status of a neonate. 0 = no pulse; 1 = rate less than 100 beats per minute; 2 = rate greater than 100 beats per minute. A component of the Apgar score, it is the numerical value assigned to an assessment of the circulatory status of a neonate. 0 = no pulse; 1 = rate less than 100 beats per minute; 2 = rate greater than 100 beats per minute. C35552 Cardiovascular System Finding C89506 NICHD Newborn Screening Terminology C87081 Heart Rhythm Heart Rhythm The recurrent, measured movements (rhythm) of a beating heart. C35552 Cardiovascular System Finding C89506 NICHD Newborn Screening Terminology C89513 Heel to Ear Measurement Heel to Ear Measurement Useful in assessing neonatal neuromuscular development, this is obtained when the infant is placed in a supine position and the infant's feet are grasped pulled toward the ipsilateral ears. The examiner measures the angle made by the arc from the table to the infant's heels; increased angle for age suggests hypotonia, and decreased angle for age suggests hypertonia. C84749 Newborn Examination C89506 NICHD Newborn Screening Terminology C84750 HELLP Syndrome HELLP Syndrome Severe preeclampsia associated with any of the following findings: thrombocytopenia (platelets less than 100,000 per microliter), impaired liver function (twice normal elevation of hepatic transaminases; severe, persistent right upper quadrant or epigastric pain), progressive renal insufficiency (serum creatinine greater than 1.1 mg/dL or doubling of baseline in the absence of other renal disease), pulmonary edema, or new-onset cerebral or visual disturbances. Severe preeclampsia associated with any of the following findings: thrombocytopenia (platelets less than 100,000 per microliter), impaired liver function (twice normal elevation of hepatic transaminases; severe, persistent right upper quadrant or epigastric pain), progressive renal insufficiency (serum creatinine greater than 1.1 mg/dL or doubling of baseline in the absence of other renal disease), pulmonary edema, or new-onset cerebral or visual disturbances. C85021 Preeclampsia C89506 NICHD Newborn Screening Terminology C3085 Hemangioma Hemangioma A benign vascular neoplasm characterized by the formation of capillary-sized or cavernous vascular channels. A benign, vascular neoplasm characterized by the formation of capillary-sized vascular channels. C3262 Neoplasm C89506 NICHD Newborn Screening Terminology C81276 Hemoglobin A to Total Hemoglobin Ratio Measurement Hemoglobin A to Total Hemoglobin Ratio Measurement The determination of the ratio of Hemoglobin A compared to total Hemoglobin present in a sample. The measurement may be expressed as a ratio or percentage. C64848 Hemoglobin Measurement C89506 NICHD Newborn Screening Terminology C81277 Hemoglobin A2 to Total Hemoglobin Ratio Measurement Hemoglobin A2 to Total Hemoglobin Ratio Measurement The determination of the ratio of Hemoglobin A2 compared to total Hemoglobin present in a sample. The measurement may be expressed as a ratio or percentage. C64848 Hemoglobin Measurement C89506 NICHD Newborn Screening Terminology C34675 Hemoglobin C Disease Hemoglobin C Disease An autosomal recessive hemoglobinopathy with a mild clinical course. Most patients are asymptomatic. When symptoms appear, they include mild hemolytic anemia and occasionally jaundice. C3092 Hemoglobinopathy C89506 NICHD Newborn Screening Terminology C81278 Hemoglobin C to Total Hemoglobin Ratio Measurement Hemoglobin C to Total Hemoglobin Ratio Measurement The determination of the ratio of Hemoglobin C compared to total Hemoglobin present in a sample. The measurement may be expressed as a ratio or percentage. C64848 Hemoglobin Measurement C89506 NICHD Newborn Screening Terminology C64848 Hemoglobin Measurement Hemoglobin Measurement A quantitative measurement of the amount of hemoglobin present in a sample. C49286 Hematology Test C89506 NICHD Newborn Screening Terminology C81279 Hemoglobin S to Total Hemoglobin Ratio Measurement Hemoglobin S to Total Hemoglobin Ratio Measurement The determination of the ratio of Hemoglobin S compared to total Hemoglobin present in a sample. The measurement may be expressed as a ratio or percentage. C64848 Hemoglobin Measurement C89506 NICHD Newborn Screening Terminology C101304 Hemolytic Disease of the Newborn Hemolytic Disease of the Newborn A disorder of the fetus or newborn that occurs when fetal cells that are coated with IgG alloantibodies from the mother attack antigens inherited from the father. Severity can range from absence of symptoms to death. A condition of the newborn characterized by the destruction of red blood cells initiated by the transmission of IgG antibodies from mother to child via the placenta. C3092 Hemoglobinopathy C98996 Neonatal Disorder C89506 NICHD Newborn Screening Terminology C87083 Heterotaxy Heterotaxy Heterotaxia The abnormal arrangement or position of thoracic and/or abdominal organs in relation to each other, often occurring in a right/left transposition. C97151 Congenital Systemic Disorder C89506 NICHD Newborn Screening Terminology C87169 High Pitched Cry High Pitched Cry An abnormally shrill or screeching vocalization made by infants that could possibly indicate the presence of one of an array of medical conditions or congenital syndromes. An abnormally shrill or screeching vocalization made by infants that could possibly indicate the presence of one of an array of medical conditions or congenital syndromes. C100104 Sign or Symptom C89506 NICHD Newborn Screening Terminology C70933 High Test Reference Range High Test Reference Range Reported upper limit of the test reference range. C38013 Range C89506 NICHD Newborn Screening Terminology C87084 Hyperemesis Gravidarum Hyperemesis Gravidarum Severe, intractable vomiting during pregnancy (usually the first trimester) accompanied by dehydration, weight loss, and electrolyte imbalances. Severe, intractable vomiting during early pregnancy accompanied by hypovolemia, weight loss, and electrolyte imbalances. C34941 Pregnancy Complication C89506 NICHD Newborn Screening Terminology C50589 Hyperthermia Hyperthermia A condition characterized by an abnormally high body temperature. In a hyperthermic state, the hypothalamic set-point is normal but body temperature increases and overrides the ability to lose heat, resulting from exogenous heat exposure or endogenous heat production. Elevation of body temperature above normal due to the production or absorption of more heat than the body is able to dissipate. C100104 Sign or Symptom C89506 NICHD Newborn Screening Terminology C87085 Hypertonia Hypertonia A condition of increased muscle tone manifested by increased resistance of the muscle to passive stretching. A condition characterized by increased resistance to passive stretching and abnormal positioning due to spasticity.|Abnormally high muscle tone. C100104 Sign or Symptom C89506 NICHD Newborn Screening Terminology C87070 Hypotonia Hypotonia A condition of decreased tone of the skeletal muscles and diminished resistance to passive stretching. A condition characterized by decreased resistance to passive stretching and diminished muscle activity.|Abnormally low muscle tone. C100104 Sign or Symptom C89506 NICHD Newborn Screening Terminology C3890 Hypoxia Hypoxia A decrease in the amount of oxygen in the body. Symptoms range from mild (impaired judgment, memory loss, impaired motor coordination) to severe (seizures and coma). A condition in which there is low oxygen in the tissues. C45233 Respiratory System Finding C89506 NICHD Newborn Screening Terminology C25737 Identification Identification The procedure of having an identity established. C92722 Qualitative Concept C89506 NICHD Newborn Screening Terminology C81289 Image Identifier Image Identifier A sequence of letters, numbers, or other characters that specifically identifies a particular image. C18772 Personal Medical History C89506 NICHD Newborn Screening Terminology C81256 Imaging Information Imaging Information A collection of data pertinent to a radiographic study. C18772 Personal Medical History C89506 NICHD Newborn Screening Terminology C48500 Inch Inch A traditional unit of length equal to 1/12 of a foot or 2.54 centimeters. C25709 Unit of Measure C89506 NICHD Newborn Screening Terminology C25180 Indicator Indicator An event, entity or condition that typically characterizes a prescribed environment or situation and determines or aids in determining whether certain stated circumstances exist or criteria are satisfied. C92722 Qualitative Concept C89506 NICHD Newborn Screening Terminology C81249 Infant Formula Infant Formula A nutritional substitute for breast milk, usually with a foundation of cow or soy milk. C1909 Pharmacologic Substance C89506 NICHD Newborn Screening Terminology C81181 Infant Reflex Infant Reflex Primitive reflex actions that newborns display in response to specific stimuli. These reflexes are involuntary and most disappear as the infant matures. Involuntary primitive reflex actions occurring in newborn infants in response to specific stimuli that disappear as the infant matures. C118807 C78342 Reflex C89506 NICHD Newborn Screening Terminology C87087 Intercostal Retractions Intercostal Retractions The marked inward movement of the muscles between the ribs during inhalation; they indicate that there is reduced pressure in the chest cavity and can be a sign of breathing difficulties. C100104 Sign or Symptom C89506 NICHD Newborn Screening Terminology C32856 Internal Nare Internal Nare The inner portion of the nostrils of the nose. C32221 Body Part C89506 NICHD Newborn Screening Terminology C87089 Irregular Respiration Irregular Respiration Irregular Breathing A change from the normal breathing pattern in an infant, child, or adult, in terms of the amplitude and frequency of inhalations and exhalations. C100104 Sign or Symptom C89506 NICHD Newborn Screening Terminology C32884 Ischium Ischium The most posterior and ventral bone making up the pelvis. C32221 Body Part C89506 NICHD Newborn Screening Terminology C25215 Karyotype Karyotype The assessment of the chromosomal morphology and number in somatic cells of an individual. The assessment of the chromosomal morphology and number in somatic cells of an individual. C15709 Genetic Testing C89506 NICHD Newborn Screening Terminology C32898 Knee Joint Knee Joint A joint connecting the lower part of the femur with the upper part of the tibia. The lower part of the femur and the upper part of the tibia are attached to each other by ligaments. Other structures of the knee joint include the upper part of the fibula, located below and parallel to the tibia, and the patella which moves as the knee bends. C32221 Body Part C89506 NICHD Newborn Screening Terminology C87090 Labial Fusion Labial Fusion Usually found in girls between 6 months and 6 years of age, this condition occurs wherein the labia grow together instead of as 2 separate folds, thereby blocking the opening of the vagina. It is caused by conditions such as repeated diaper rash, urine and stool infections, and sexual abuse. The condition often spontaneously corrects or responds to the application of estrogen cream. C103185 Congenital Reproductive System Abnormality C89506 NICHD Newborn Screening Terminology C25294 Laboratory Procedure Laboratory Procedure Any procedure that involves testing or manipulating a sample of blood, urine, or other body substance in a laboratory setting. C18020 Diagnostic Procedure C89506 NICHD Newborn Screening Terminology C36292 Laboratory Test Result Laboratory Test Result The outcome of a laboratory test. C3367 Finding C89506 NICHD Newborn Screening Terminology C34197 Lanugo Lanugo Fine downy hair that covers the body of a human fetus beginning in the fifth month of gestation; it is usually shed by the ninth month of gestation. C32221 Body Part C89506 NICHD Newborn Screening Terminology C87092 Large for Gestational Age Large for Gestational Age A fetus or infant who is larger than expected for the age or gender, or who has a birth weight greater than the 90th percentile. A newborn infant who has a birth weight greater than the 90th percentile based on gestational age.|An estimated fetal or neonatal weight exceeding 90% of expected weight for gestational age. C92711 Fetal Finding C89506 NICHD Newborn Screening Terminology C81310 Lasso-O Measuring Tape Lasso-O Measuring Tape A measuring tape frequently used to measure head circumference in newborns. A measuring tape frequently used to measure head circumference in newborns. It can measure any circumference to the nearest millimeter and is manufactured from paper-thin, non-stretch, non-shrink plastic. C62103 C89506 NICHD Newborn Screening Terminology C81257 Last Menstrual Period Last Menstrual Period The first day of the female's last menstrual cycle. C92720 C89506 NICHD Newborn Screening Terminology C81258 Last Screening Last Screening The most recent screening. C25164 Date C89506 NICHD Newborn Screening Terminology C81259 Left Ear Left Ear The organ of hearing located on the left side of the head. C12394 Ear C89506 NICHD Newborn Screening Terminology C32974 Leg Leg One of the two lower extremities in humans used for locomotion and support. C32221 Body Part C89506 NICHD Newborn Screening Terminology C25334 Length Length The linear extent in space from one end of something to the other end, or the extent of something from beginning to end. C25447 Characteristic C89506 NICHD Newborn Screening Terminology C12220 Lip Lip Fleshy fold which surrounds the opening of the mouth. C32221 Body Part C89506 NICHD Newborn Screening Terminology C81260 Local Anesthesia Procedure Local Anesthesia Procedure The temporary suppression of sensation at a specific region of the body by pharmacological intervention. This type of anesthesia does not induce unconsciousness in the patient. C15181 Anesthesia Procedure C89506 NICHD Newborn Screening Terminology C87128 Loose Stool Loose Stool Watery Stool Frequent, loose, and watery stools are noted in most infants, even if they are fed formula, until they are six to eight weeks old; after that, the stools become firmer and less frequent. C100104 Sign or Symptom C89506 NICHD Newborn Screening Terminology C34724 Low Birth Weight Low Birth Weight A birth weight that is less than 2500 grams. Birth weight less than 2500 grams. C76325 Birth Weight C89506 NICHD Newborn Screening Terminology C70934 Low Test Reference Range Low Test Reference Range Reported low limit of the test reference range. C38013 Range C89506 NICHD Newborn Screening Terminology C50644 Lung Overinflation Lung Overinflation Abnormal permanent enlargement of the lung air spaces distal to terminal bronchiole not resulted from wall destruction, e.g. due to loss of opposite lung. C100104 Sign or Symptom C89506 NICHD Newborn Screening Terminology C25381 Maiden Name Maiden Name A woman's surname before marriage. C90492 Personal Information C89506 NICHD Newborn Screening Terminology C20197 Male Male A person who belongs to the sex that normally produces sperm. The term is used to indicate biological sex distinctions, cultural gender role distinctions, or both. C28421 Sex C89506 NICHD Newborn Screening Terminology C87068 Male Circumcision Male Circumcision Circumcision Surgical removal of the penile foreskin. Surgical removal of the penile foreskin. C15329 C89506 NICHD Newborn Screening Terminology C17770 Maturation Maturation The act, or process, of natural progression in physical and psychological maturation from a previous, lower, or embryonic stage to a later, more complex, or adult stage. C19988 Organismal Process C89506 NICHD Newborn Screening Terminology C87093 Meconium Aspiration Syndrome Meconium Aspiration Syndrome A serious condition in which a newborn breathes a mixture of meconium (the first intestinal discharge) and amniotic fluid into the lungs around the time of delivery. Meconium aspiration syndrome occurs in 5-10 percent of births and typically occurs when the infant is stressed, as when the infant is past its due date. Aspiration of meconium around the time of delivery resulting in severe respiratory distress. C97173 Congenital Respiratory System Disorder C89506 NICHD Newborn Screening Terminology C81262 Medical Record Number Medical Record Number An identifying number within an institution that is used to reference a subject's medical information. C18772 Personal Medical History C89506 NICHD Newborn Screening Terminology C90603 Medication Administered at Birth Medication Administered at Birth Medication Given at Birth Pharmacologic agents administered to a neonate at birth. C49236 Therapeutic Procedure C89506 NICHD Newborn Screening Terminology C81263 Mental Development Index Mental Development Index A sequential arrangement of information pertaining to the evolution of an individual's cognitive development. C81314 Newborn Behavioral Examination C89506 NICHD Newborn Screening Terminology C81264 Mental Scale Mental Scale A range of values that characterizes an individual's mental development. C81314 Newborn Behavioral Examination C89506 NICHD Newborn Screening Terminology C87094 Micrognathism Micrognathism A congenital abnormality of the jaws (particularly the mandible) in which they are unusually small. This condition is not always pathological and may correct itself as the patient matures; however, it may also present as a birth defect in multiple syndromes. C89337 Congenital Musculoskeletal Defect C89506 NICHD Newborn Screening Terminology C67405 Microinternational Unit per Milliliter Microinternational Unit per Milliliter Unit of arbitrary substance concentration (biologic activity concentration) defined as the concentration of one millionth of international unit per one milliliter of system volume. C25709 Unit of Measure C89506 NICHD Newborn Screening Terminology C67015 Milligram per Deciliter Milligram per Deciliter A unit of mass concentration defined as the concentration of one milligram of a substance in unit volume of the mixture equal to one cubic deciliter or 100 cubic centimeters. It is also a unit of mass density (volumic mass) defined as the density of substance which mass equal to one milligram occupies the volume one cubic deciliter or 100 cubic centimeters. C25709 Unit of Measure C89506 NICHD Newborn Screening Terminology C64387 Millimole per Liter Millimole per Liter A unit of concentration (molarity unit) equal to one thousandth of a mole (10E-3 mole) of solute per one liter of solution. C25709 Unit of Measure C89506 NICHD Newborn Screening Terminology C41147 Modality Modality A specific manner, characteristic, pattern of application or the employment of, any therapeutic agent or method of treatment, especially involving the physical treatment of a condition. C25447 Characteristic C89506 NICHD Newborn Screening Terminology C81268 Molar Ratio Molar Ratio The relative number of moles of one substance to another in a chemical reaction. C25709 Unit of Measure C89506 NICHD Newborn Screening Terminology C81311 Moro Reflex Moro Reflex An involuntary, primal response in the neonate to loud noise or the feeling of falling. The response is characterized by the infant's arms symmetrically spreading out to the side and then back to the midline, and involuntarily flexing the fingers and toes. An involuntary response in the neonate to the feeling of falling or a loud noise characterized by the infant's arms symmetrically spreading out to the side and then back to the midline, and flexion of the fingers and toes, that disappears by 4-6 months of age. C81181 Infant Reflex C89506 NICHD Newborn Screening Terminology C81269 Motor Development Motor Development The evolution of physical movement over an individual's lifespan. C17770 Maturation C89506 NICHD Newborn Screening Terminology C5039 Motor Manifestations Motor Manifestations The presence of an alteration in the ability to move one's body or any body parts in accordance with one's intent. C100104 Sign or Symptom C89506 NICHD Newborn Screening Terminology C87095 Mottling Mottling Irregularly shaped, patchy discolorations in the skin. A patchy appearance of the skin caused by underlying blood vessel changes.|Irregularly shaped and discolored patches on the skin. C36281 Integumentary System Finding C100104 Sign or Symptom C89506 NICHD Newborn Screening Terminology C87096 Movement of Lip Corners Movement of Lip Corners During examination of the newborn infant, the examiner looks for symmetric movement of the lip corners. Movement of the lip corners is governed by the zygomatic major muscle. C100104 Sign or Symptom C89506 NICHD Newborn Screening Terminology C81271 Multiple Birth Multiple Birth Multiple fetuses birthed live or dead in a single pregnancy regardless of gestational age, and regardless of whether the fetuses were birthed on different dates. Multiple fetuses birthed live or dead in a single pregnancy regardless of gestational age, and regardless of whether the fetuses were birthed on different dates. C25742 Pregnancy C90491 C89506 NICHD Newborn Screening Terminology C81312 Muscle Tone Score Muscle Tone Score A component of the Apgar score, it is the numerical value assigned to an assessment of the residual muscle tension of a neonate. 0 = flaccid; 1 = flexion of extremities; 2 = active motion. A component of the Apgar score, it is the numerical value assigned to an assessment of the residual muscle tension of a neonate. 0 = flaccid; 1 = flexion of extremities; 2 = active motion. C118807 C89506 NICHD Newborn Screening Terminology C34832 Myoclonic Jerk Myoclonic Jerk A sudden, involuntary contraction of a muscle or group of muscles; these movements may develop as a symptom of a number of neurological diseases including epilepsy, Parkinson's disease, Alzheimer's disease, or Creutzfeldt-Jacob disease. C100104 Sign or Symptom C89506 NICHD Newborn Screening Terminology C67326 Nanogram per Deciliter Nanogram per Deciliter A unit of mass concentration defined as the concentration of one nanogram of a substance per unit volume of the mixture equal to one deciliter. The concept also refers to the unit of mass density (volumic mass) defined as the density of substance which mass equal to one nanogram occupies the volume of one deciliter. C25709 Unit of Measure C89506 NICHD Newborn Screening Terminology C78500 Nasal Congestion Nasal Congestion The blockage of the nasal passage due to mucosal edema. It is usually the result of a viral infection or an allergic reaction. The blockage of the nasal passage due to mucosal edema or secretions. C100104 Sign or Symptom C89506 NICHD Newborn Screening Terminology C87099 Nasal Flaring Nasal Flaring Enlargement of the nostrils during breathing; although there are many possible causes, it can be a sign of respiratory distress in young infants. C100104 Sign or Symptom C89506 NICHD Newborn Screening Terminology C13063 Neck Neck The region that connects the head to the rest of the body. C32221 Body Part C89506 NICHD Newborn Screening Terminology C87101 Neonatal Abstinence Syndrome Neonatal Abstinence Syndrome A constellation of neurobehavioral features observed in a neonate following antenatal exposure to drugs including opioids, benzodiazepines, and selective serotonin reuptake inhibitors. A constellation of neurobehavioral features observed in a neonate following antenatal exposure to drugs including opioids, benzodiazepines, and selective serotonin reuptake inhibitors. C101321 Neonatal Drug Withdrawal C89506 NICHD Newborn Screening Terminology C89515 Neonatal Abstinence Syndrome Assessment Neonatal Abstinence Syndrome Assessment The measurement of the degree to which a neonate is experiencing symptoms of withdrawal due to maternal substance abuse; the score can be used to determine subsequent treatment of the infant. C84749 Newborn Examination C89506 NICHD Newborn Screening Terminology C84923 Neural Tube Defect Neural Tube Defect A congenital defect characterized by failure of the neural tube to close completely; this results in the presence of openings in the brain or spinal cord. Examples of neural tube defects include encephalocele and spina bifida. C97172 Congenital Nervous System Disorder C89506 NICHD Newborn Screening Terminology C81313 Neurologic Examination Neurologic Examination The assessment of the functionality of the brain, spinal column, and nerves. C25214 Evaluation Procedure C89506 NICHD Newborn Screening Terminology C89339 Neurological Screening Neurological Screening A specific type of neurologic examination for early detection of disease(s) and/or disorder(s). C81313 Neurologic Examination C89506 NICHD Newborn Screening Terminology C89516 Neuromuscular Maturity Assessment Neuromuscular Maturity Assessment A neuromuscular examination of a newborn's developmental characteristics. A neuromuscular examination of a newborn's developmental characteristics to confirm or assign gestational age. C84749 Newborn Examination C89506 NICHD Newborn Screening Terminology C16731 Newborn Newborn An infant during the first month after birth. C16423 Child C89506 NICHD Newborn Screening Terminology C81314 Newborn Behavioral Examination Newborn Behavioral Examination The assessment of behavior in neonates. C84749 Newborn Examination C89506 NICHD Newborn Screening Terminology C87105 Newborn Blood Pressure Newborn Blood Pressure The systolic and diastolic blood pressure of the newborn upon examination; the normal range of the systolic blood pressure is 60 - 90, while the normal range of the diastolic blood pressure is 20-60. C118807 C89506 NICHD Newborn Screening Terminology C84749 Newborn Examination Newborn Examination A general assessment of the overall health of a newborn. A general assessment of the overall health of a newborn. C90341 Pediatric Intervention or Procedure C89506 NICHD Newborn Screening Terminology C87103 Newborn Heart Rate Newborn Heart Rate The number of heartbeats of the newborn per minute; the normal range is 100 - 180 heartbeats per minute. C49677 Heart Rate C89506 NICHD Newborn Screening Terminology C81270 Newborn Motor Scale Newborn Motor Scale A range of values used to quantify newborn motor development. C118807 C89506 NICHD Newborn Screening Terminology C87104 Newborn Respiratory Rate Newborn Respiratory Rate The number of inhalations and exhalations of the newborn per minute; the normal range is 30 - 60 breaths per minute. C49678 Respiratory Rate C89506 NICHD Newborn Screening Terminology C81178 Newborn Screening Newborn Screening A specific type of newborn examination performed to allow for early detection of disease(s) and/or disorder(s). A specific type of newborn examination performed to allow for early detection of disease(s) and/or disorder(s). C84749 Newborn Examination C89506 NICHD Newborn Screening Terminology C49487 No No The non-affirmative response to a question. C25180 Indicator C89506 NICHD Newborn Screening Terminology C78727 Normal Reference Range Normal Reference Range Reported values within the typical or expected range. C38013 Range C89506 NICHD Newborn Screening Terminology C94835 Normal Spontaneous Vaginal Delivery Normal Spontaneous Vaginal Delivery Normal Delivery Birth of the fetus through the vagina without the application of vacuum or forceps or any other instrument. (adapted from reVITALize) Birth of the fetus through the vagina without the application of vacuum or forceps or any other instrument. [adapted from reVITALize] C81303 Vaginal Delivery C89506 NICHD Newborn Screening Terminology C12756 Nose Nose A structure of special sense serving as an organ of the sense of smell and as an entrance to the respiratory tract. C32221 Body Part C89506 NICHD Newborn Screening Terminology C28294 Nutrition Nutrition That which is consumed to fuel necessary life processes of an organism. C45306 Substance C89506 NICHD Newborn Screening Terminology C25598 Observation Observation Watching something and taking note of what happens. C18020 Diagnostic Procedure C89506 NICHD Newborn Screening Terminology C81227 One Minute After Birth One Minute After Birth The actual time that is one minute after the birth of a fetus. This period is most commonly referenced during the administration of the Apgar test. C25207 Time C89506 NICHD Newborn Screening Terminology C12421 Oral Cavity Oral Cavity The cavity located at the upper end of the alimentary canal, behind the teeth and gums that is bounded on the outside by the lips, above by the hard and soft palates and below by the tongue. C32221 Body Part C89506 NICHD Newborn Screening Terminology C89517 Ortolani Maneuver Ortolani Maneuver When testing for congenital dislocation of the hip, this is the result obtained when the examiner gently abducts the hip while pushing upward on the greater trochanter. If the hip is dislocated, it will relocate with an audible clunk, which is a positive result for this test. C84749 Newborn Examination C89506 NICHD Newborn Screening Terminology C17649 Other Other Different than the one(s) previously specified or mentioned. C25180 Indicator C89506 NICHD Newborn Screening Terminology C48519 Ounce Ounce The traditional unit of mass. The avoirdupois ounce is equal to 1/16 pound, or 28.3495 grams, or 0.911 457 troy ounce. C25709 Unit of Measure C89506 NICHD Newborn Screening Terminology C50685 Pallor Pallor An unusual or extreme paleness, state of decreased skin or mucosal coloration. A condition characterized by an abnormal loss of color to the skin or mucous membranes due to reduced delivery of saturated hemoglobin.|An unusual or extreme paleness; state of decreased skin or mucosal color. C100104 Sign or Symptom C89506 NICHD Newborn Screening Terminology C89514 Palmar Crease Examination Palmar Crease Examination Inspection of palm crease When examining the infant's palm for abnormalities, the examiner may note a single transverse palmar crease, which is found in 5% of newborns and is frequently inherited as a familial trait. However, single palmar creases can be associated with Down's syndrome and other genetic disorders, or with fetal alcohol syndrome. C84749 Newborn Examination C89506 NICHD Newborn Screening Terminology C81275 Pass Pass One of two possible results of a pass/fail assessment; when the result satisfies a condition. C25180 Indicator C89506 NICHD Newborn Screening Terminology C89328 Childhood Disorder Pediatric Disorder Pediatric Disease or Disorder A non-neoplastic or neoplastic disorder which occurs during childhood. C2991 Disease or Disorder C89506 NICHD Newborn Screening Terminology C25190 Person Person A human being. C89505 Prenatal and Pediatric Terminology C89506 NICHD Newborn Screening Terminology C25191 Person Name Person Name A word or group of words indicating the identity of a person usually consisting of a first (personal) name and a last (family) name with an optional middle name. In some cultural traditions the family name comes first. C90492 Personal Information C89506 NICHD Newborn Screening Terminology C90492 Personal Information Personal Information Data, facts or figures about an individual; the set of relevant items would depend on the use case. C20189 Property or Attribute C89506 NICHD Newborn Screening Terminology C18772 Personal Medical History Personal Medical History A record of a patient's background regarding health and the occurrence of disease events of the individual. In addition, personal medical history may be a variable in epidemiologic studies. C90492 Personal Information C89506 NICHD Newborn Screening Terminology C81280 Phenylalanine Measurement Phenylalanine Measurement The measurement of the amount of phenylalanine in a biologic specimen. C81183 Amino Acid Measurement C89506 NICHD Newborn Screening Terminology C81281 Phenylalanine to Tyrosine Ratio Measurement Phenylalanine to Tyrosine Ratio Measurement The determination of the ratio of phenylalanine compared to tyrosine present in a sample. The measurement may be expressed as a ratio or percentage. C81183 Amino Acid Measurement C89506 NICHD Newborn Screening Terminology C81315 Phenylketonuria Phenylketonuria An autonomic recessive genetic disorder characterized by the body's inability to metabolize and utilize the amino acid phenylalanine, resulting in mental retardation, behavioral and movement problems, seizures, and developmental delays. C97090 Amino Acid Metabolism Disorder C3101 Genetic Disorder C89506 NICHD Newborn Screening Terminology C20989 Physical Examination Physical Examination A systemic evaluation of the body and its functions using visual inspection, palpation, percussion and auscultation. The purpose is to determine the presence or absence of physical signs of disease or abnormality for an individual's health assessment. C25214 Evaluation Procedure C89506 NICHD Newborn Screening Terminology C89518 Physical Maturity Assessment Physical Maturity Assessment A physical examination of a newborn's developmental characteristics. A physical examination of a newborn's developmental characteristics to confirm or assign gestational age. C84749 Newborn Examination C89506 NICHD Newborn Screening Terminology C81316 Physical Symmetry Physical Symmetry A physical attribute of visual balance and proportion between opposing structures. C25447 Characteristic C89506 NICHD Newborn Screening Terminology C41148 Placement Placement Position or arrangement, as of the teeth; the state of being placed or arranged, as the assignment of a person to a appropriate clinical study. C92722 Qualitative Concept C89506 NICHD Newborn Screening Terminology C81297 Point in Time Test Given Point in Time Test Given The hour, minute, and/or second that an examination was administered. C25207 Time C89506 NICHD Newborn Screening Terminology C87110 Polydactyly Polydactyly A congenital abnormality characterized by more than 5 digits on a hand or foot. C89337 Congenital Musculoskeletal Defect C89506 NICHD Newborn Screening Terminology C87111 Poor Feeding Poor Feeding Occurs either when an infant shows no interest in feeding or when there is an inability to take in adequate nutrition. Poor feeding is a nonspecific symptom of many disorders, including neurological, genetic, structural, metabolic, and infectious diseases. A non-specific symptom characterized by inadequate oral nutritional intake that may be associated with several different disorders. C100104 Sign or Symptom C89506 NICHD Newborn Screening Terminology C89519 Popliteal Angle Measurement Popliteal Angle Measurement An examination whereby the patient is placed supine, the hip is flexed 90 degrees, and the knee is extended until firm resistance is met. The popliteal angle is the angle from the tibia to the femur. This measurement is used to assess hamstring contracture in children with cerebral palsy. C84749 Newborn Examination C89506 NICHD Newborn Screening Terminology C25621 Postal Code Postal Code Any system designed to expedite the sorting and delivery of mail by assigning a series of alphanumeric codes to each delivery area. Also used to refer to any individual delivery area code. C16495 Demographics C89506 NICHD Newborn Screening Terminology C48531 Pound Pound The traditional unit of mass. By international agreement, one avoirdupois pound is equal to exactly 0.453 592 37 kilogram, 16 ounces, or 1.215 28 troy pounds. C25709 Unit of Measure C89506 NICHD Newborn Screening Terminology C85021 Preeclampsia Preeclampsia A systolic blood pressure of 140 mmHg or higher, or a diastolic blood pressure of 90 mmHg or higher on two occasions at least 4 hours apart (or greater than or equal to 160/110 mmHg within a short interval) after 20 weeks of gestation in a woman with previously normal blood pressure. It may present with proteinuria but if not, it may be associated with thrombocytopenia, impaired liver function, progressive renal insufficiency, pulmonary edema, or new-onset cerebral or visual disturbances. A systolic blood pressure of 140 mmHg or higher, or a diastolic blood pressure of 90 mmHg or higher on two occasions at least 4 hours apart (or greater than or equal to 160/110 mmHg within a short interval) after 20 weeks of gestation in a woman with previously normal blood pressure. It may present with proteinuria but if not, it may be associated with thrombocytopenia, impaired liver function, progressive renal insufficiency, pulmonary edema, or new-onset cerebral or visual disturbances. C4371 Gestational Hypertension C89506 NICHD Newborn Screening Terminology C34941 Pregnancy Complication Pregnancy Complication The co-occurrence of pregnancy and a disease. The disease may precede or follow conception and it may or may not have a deleterious effect on the pregnant woman or fetus. C2959 Complication C89506 NICHD Newborn Screening Terminology C87113 Premature Rupture of Membrane Premature Rupture of Membranes PROM Spontaneous rupture of fetal membranes that occurs before the onset of labor. If rupture occurs before 37 weeks of gestation then the correct diagnosis is preterm premature rupture of membranes. Spontaneous rupture of fetal membranes that occurs before the onset of labor. If rupture occurs before 37 weeks of gestation then the correct diagnosis is preterm premature rupture of membranes. C34941 Pregnancy Complication C89506 NICHD Newborn Screening Terminology C87114 Proptosis Proptosis Abnormal protrusion of one or both eyes from the socket; causes include hyperthyroidism (particularly Graves disease); bleeding behind the eye; infection, inflammation, or tumors of the orbit; and vascular disorders. C99208 Eye Finding C89506 NICHD Newborn Screening Terminology C49676 Pulse Rate Pulse Rate The rate of the pulse as observed in an artery, expressed as beats per minute. It can be measured at several anatomical sites, including the wrist, neck, temple, groin, behind the knees, or on top of the foot. C35552 Cardiovascular System Finding C89506 NICHD Newborn Screening Terminology C87107 Pupils Equal Round and Reactive to Light Pupils Equal Round and Reactive to Light Pupils Equal Round and Reactive to Light Result While performing an assessment of the eyes, the examiner notes whether the pupils are equal, round, and reactive to light. If all findings are normal, the abbreviation PERRL is noted in the examiner's account of the physical examination. C36280 C89506 NICHD Newborn Screening Terminology C87108 Pupils Equal Round and Reactive to Light and Accommodation Pupils Equal Round and Reactive to Light and Accommodation Pupils Equal Round and Reactive to Light and Accommodation Result While performing an assessment of the eyes, the examiner notes whether the pupils are equal and round, reactive to light, and have the ability to accommodate. If all findings are normal, the abbreviation PERRLA is noted in the examiner's account of the physical examination. C36280 C89506 NICHD Newborn Screening Terminology C17049 Race Race An arbitrary classification of a taxonomic group that is a division of a species. It usually arises as a consequence of geographical isolation within a species and is characterized by shared heredity, physical attributes and behavior, and in the case of humans, by common history, nationality, or geographic distribution. C16495 Demographics C89506 NICHD Newborn Screening Terminology C38013 Range Range The difference between the lowest and highest numerical values; the limits or scale of variation. C70766 Quantitative Concept C89506 NICHD Newborn Screening Terminology C12390 Rectum Rectum The terminal portion of the gastrointestinal tract, extending from the rectosigmoid junction to the anal canal. C32221 Body Part C89506 NICHD Newborn Screening Terminology C81283 Red Reflex Test Red Reflex Test Red Reflex Vision Test An optic examination in which an ophthalmoscope or retinoscope is placed approximately 30cm from the eye to visualize whether a reddish hue is reflected from the retina. An optic examination in which an ophthalmoscope or retinoscope is placed in front of the eye to determine whether a circular reddish hue is visible. C84749 Newborn Examination C89506 NICHD Newborn Screening Terminology C52582 Referral Referral Sending a patient from one practitioner to another for health care services. C49236 Therapeutic Procedure C89506 NICHD Newborn Screening Terminology C81319 Reflex Irritability Score Reflex Irritability Score A component of the Apgar score, it is the numerical value assigned to the neonate's response to stimuli, such as a mild pinch. 0 = no reaction; 1 = grimace; 2 = grimace with a cough, sneeze, or vigorous cry. A component of the Apgar score, it is the numerical value assigned to the neonate's response to tactile stimuli. 0 = no reaction; 1 = grimace; 2 = grimace with a cough, sneeze, or vigorous cry. C118807 C89506 NICHD Newborn Screening Terminology C64381 Regional Anesthesia Procedure Regional Anesthesia Procedure The administration of pharmaceutical agents intended to produce loss of sensation in a particular anatomical region. C15181 Anesthesia Procedure C89506 NICHD Newborn Screening Terminology C50726 Regurgitation Regurgitation Flow in the opposite direction from normal, as the casting up of undigested food or gas from the stomach, or the backward flowing of blood into the heart, or between the chambers of the heart when a valve is incompetent. C100104 Sign or Symptom C89506 NICHD Newborn Screening Terminology C81284 Residential Telephone Number Residential Telephone Number The sequence of numbers or characters, that when dialed, connects to a particular residential telephone. C40978 Telephone Number C89506 NICHD Newborn Screening Terminology C49678 Respiratory Rate Respiratory Rate The rate of breathing (inhalation and exhalation) measured within in a unit time, usually expressed as breaths per minute. C45233 Respiratory System Finding C89506 NICHD Newborn Screening Terminology C87116 Rhonchi Rhonchi An abnormal sound similar to snoring heard on auscultation of the bronchial airways, suggesting a partial obstruction due to thick secretions, a muscular spasm, or a neoplasm. C100104 Sign or Symptom C89506 NICHD Newborn Screening Terminology C81285 Right Ear Right Ear The organ of hearing located on the right side of the head. C12394 Ear C89506 NICHD Newborn Screening Terminology C90498 Risk Factor Assessment Risk Factor Assessment A systematic gathering of information regarding the variables associated with an individual's increased risk of disease or infection. C25214 Evaluation Procedure C89506 NICHD Newborn Screening Terminology C81320 Rooting Reflex Rooting Reflex An involuntary, primal response in the neonate to search for the nipple when the cheek is touched. An involuntary response in the neonate to search for the nipple when the cheek is touched, that disappears by 3-4 months of age. C81181 Infant Reflex C89506 NICHD Newborn Screening Terminology C87118 Sacral Dimple Sacral Dimple A small hollow area or sinus present at birth and located just above the crease of the buttocks. In most cases, pilonidal dimples are benign and may just be accompanied by increased hair growth in the area. A blind-ending, epithelial-lined tract that is located 5-25 mm from the anal verge. C100104 Sign or Symptom C89506 NICHD Newborn Screening Terminology C81288 S-Beta Thalassemia S-Beta Thalassemia A disorder characterized by the body's inability to synthesize beta-globin chains, leading to the formation of abnormal hemoglobin and anemia. This inherited autosomal recessive blood disorder is caused by germline mutation of the HBB gene. C35069 Thalassemia C89506 NICHD Newborn Screening Terminology C89521 Scarf Sign Scarf Sign When testing the newborn infant for neuromuscular maturity, the "scarf sign" test is carried out by drawing the newborn's arm across the chest to the opposite shoulder until resistance is felt. In term infants, the elbow should not cross the midline of the chest. C84749 Newborn Examination C89506 NICHD Newborn Screening Terminology C2962 Seizure Seizure Sudden, involuntary skeletal muscular contractions of cerebral or brain stem origin. A paroxysmal surge of electrical activity in the brain that may result in physical or behavioral changes. C87124 Central Nervous System Signs and Symptoms C89506 NICHD Newborn Screening Terminology C28421 Sex Sex The assemblage of physical properties or qualities by which male is distinguished from female; the physical difference between male and female; the distinguishing peculiarity of male or female. C25447 Characteristic C89506 NICHD Newborn Screening Terminology C25203 Shoulder Shoulder The region of the body between the neck and the upper arm. C32221 Body Part C89506 NICHD Newborn Screening Terminology C81290 Shoulder Dystocia Shoulder Dystocia A birth complication caused by impaction of the anterior shoulder against the maternal symphysis pubis that requires additional maneuvers to relieve impaction of the fetal shoulder and allow for delivery. A birth complication caused by impaction of the anterior shoulder against the maternal symphysis pubis that requires additional maneuvers to relieve impaction of the fetal shoulder and allow for delivery. C81236 Birth Complication C89506 NICHD Newborn Screening Terminology C81291 Sick Newborn Sick Newborn A neonate that is unwell. C16731 Newborn C89506 NICHD Newborn Screening Terminology C34383 Sickle Cell Disease Sickle Cell Disease A blood disorder characterized by the appearance of sickle-shaped red blood cells and anemia. C3092 Hemoglobinopathy C89506 NICHD Newborn Screening Terminology C100104 Sign or Symptom Sign or Symptom Signs or Symptoms Objective evidence of disease perceptible to the examining practitioner (sign) and subjective evidence of disease perceived by the patient (symptom). C3367 Finding C89506 NICHD Newborn Screening Terminology C87120 Single Palmar Crease Single Palmar Crease A single transverse palmar crease is found in 5% of newborns and is frequently inherited as a familial trait. However, single palmar creases can be associated with Down's syndrome and other genetic disorders, or with fetal alcohol syndrome. C100104 Sign or Symptom C89506 NICHD Newborn Screening Terminology C87121 Situs Inversus Situs Inversus A congenital condition in which there is complete right-to-left reversal of the position of the major thoracic and abdominal organs (that is, they are arranged in a mirror image of the normal positioning). C97151 Congenital Systemic Disorder C89506 NICHD Newborn Screening Terminology C81321 Skin Color Score Skin Color Score A component of the Apgar score, it is the numerical value assigned to an assessment of the color of the skin of a neonate. 0 = pale blue; 1 = pink body and pale blue extremities; 2 = pink body and extremities. A component of the Apgar score, it is the numerical value assigned to an assessment of the color of the skin of a neonate. 0 = blue; 1 = pink body and blue extremities; 2 = pink body and extremities. C36281 Integumentary System Finding C89506 NICHD Newborn Screening Terminology C73425 Sleep Sleep A natural and periodic state of rest during which consciousness of the world is suspended. C16326 Behavior C89506 NICHD Newborn Screening Terminology C29719 Smoking History Smoking History A record of an individual's background in regard to smoking tobacco. This would include such factors as start date, end date (if applicable), number of cigarette smoked, attempts to quit, and others. C18772 Personal Medical History C89506 NICHD Newborn Screening Terminology C50746 Sneezing Sneezing A symptom consisting of the involuntary expulsion of air from the nose. The involuntary expulsion of air from the nose. C100104 Sign or Symptom C89506 NICHD Newborn Screening Terminology C81292 Social History Social History Past events that occurred between individuals and/or their communities. C18772 Personal Medical History C89506 NICHD Newborn Screening Terminology C34781 Spastic Diplegia Spastic Diplegia A type of cerebral palsy characterized by spasticity and hypertonia of the lower extremities bilaterally, particularly the legs, hips, and pelvis; this is the most common (70%) form of cerebral palsy. A type of spastic cerebral palsy characterized by increased muscle tone of the lower extremities bilaterally, particularly the legs, hips, and pelvis. C34460 Cerebral Palsy C89506 NICHD Newborn Screening Terminology C89520 Square Window Square Window When testing the newborn infant for neuromuscular maturity, the "square window" test measures wrist flexibility and resistance to extensor stretching, The examiner straightens the infant's fingers and applies gentle pressure on the dorsum of the hand, close to the fingers, and then estimates the angle between the palm of the hand and the forearm. C84749 Newborn Examination C89506 NICHD Newborn Screening Terminology C81322 Step Reflex Step Reflex An involuntary, primal response in the neonate to take brisk steps when the feet are placed on a surface whilst in a supported standing position. C81181 Infant Reflex C89506 NICHD Newborn Screening Terminology C35040 Strabismus Strabismus Strabismus is the intermittent or constant misalignment of an eye so that its line of vision is not pointed at the same object as the other eye. Strabismus is caused by an imbalance in the extraocular muscles which control the positioning of the eyes. Strabismus is normal in newborns but should resolve by the time the baby is 6 months old. In older children with strabismus, the brain may learn to ignore the input from one eye, and this may lead to amblyopia, a potentially permanent decrease in vision in that eye if not corrected. C26767 C89506 NICHD Newborn Screening Terminology C81293 Street Number Street Number The numeric or alphabetic identifier of a building on a thoroughfare. C16495 Demographics C89506 NICHD Newborn Screening Terminology C81294 Submitting Facility Submitting Facility The hospital or medical institution that is submitting data or information. C16495 Demographics C89506 NICHD Newborn Screening Terminology C81323 Sucking Reflex Sucking Reflex An involuntary, primal response in the neonate when a nipple is placed on an infant's lips. An involuntary response in the neonate when a nipple is placed on an infant's lips to rhythmically suck, that disappears by 2-5 months of age. C81181 Infant Reflex C89506 NICHD Newborn Screening Terminology C36172 Sweating Sweating A watery secretion by the sweat glands that is primarily composed of salt, urea and minerals. C100104 Sign or Symptom C89506 NICHD Newborn Screening Terminology C87125 Syndactyly Syndactyly A congenital condition characterized by webbing between the fingers and/or toes, joining the digits together. In rare cases, the joining of the fingers or toes may involve bony fusion between the digits. Common causes include Down Syndrome and hereditary syndactyly. C89337 Congenital Musculoskeletal Defect C89506 NICHD Newborn Screening Terminology C40978 Telephone Number Telephone Number A sequence of decimal digits (0-9) that is used for identifying a destination telephone line or other device in a telephone network. C90492 Personal Information C89506 NICHD Newborn Screening Terminology C25206 Temperature Temperature A measure of the average kinetic energy of a system of particles. Temperature may be quantified, in the context of thermodynamics, as the potential of one system to transfer thermal energy to another system until both systems reach a state of thermal equilibrium. C25447 Characteristic C89506 NICHD Newborn Screening Terminology C21514 Temporal Qualifier Temporal Qualifier Terms used to indicate units of time or other terms associated with time. C20189 Property or Attribute C89506 NICHD Newborn Screening Terminology C89333 Term Infant Term Infant Full Term Neonate A newborn infant greater than or equal to 37 weeks, 0 days and less than or equal to 41 weeks, 6 days gestational age. A newborn infant greater than or equal to 37 weeks, 0 days and less than or equal to 41 weeks, 6 days gestational age. C16731 Newborn C89506 NICHD Newborn Screening Terminology C49236 Therapeutic Procedure Therapeutic Procedure An action or administration of therapeutic agents to produce an effect that is intended to alter or stop a pathologic process. C25218 Intervention or Procedure C89506 NICHD Newborn Screening Terminology C12799 Thorax Thorax The division of the body lying between the neck and the abdomen. C32221 Body Part C89506 NICHD Newborn Screening Terminology C85189 Thyroglossal Duct Cyst Thyroglossal Duct Cyst A congenital benign cyst arising from the remnants of the thyroglossal duct. It is usually located in the midline of the neck. C2978 Cyst C89506 NICHD Newborn Screening Terminology C64813 Thyrotropin Measurement Thyrotropin Measurement A quantitative measurement of the amount of thyrotropin present in a sample. C74742 Hormone Measurement C89506 NICHD Newborn Screening Terminology C25207 Time Time The continuum of experience in which events pass from the future through the present to the past. C20189 Property or Attribute C89506 NICHD Newborn Screening Terminology C33788 Toe Toe One of the terminal digits of the foot. C32221 Body Part C89506 NICHD Newborn Screening Terminology C81324 Tonic Neck Reflex Tonic Neck Reflex An involuntary, primal response in the neonate in which the arm extends to follow the infant's gaze, while the opposing arm and leg flex inward. An involuntary response in the neonate in which the arm extends to follow the infant's gaze, while the opposing arm and leg flex inward, that disappears by 4-6 months of age. C81181 Infant Reflex C89506 NICHD Newborn Screening Terminology C81298 Total Body Length Total Body Length The total linear extent of the body. The total linear extent of the body measured from the crown of the head to the heel in the recumbent position. C25334 Length C89506 NICHD Newborn Screening Terminology C74794 Total Thyroxine Measurement Total Thyroxine Measurement The determination of the amount of free and bound thyroxine present in a sample. C74742 Hormone Measurement C89506 NICHD Newborn Screening Terminology C81325 Transferase Deficiency Galactosemia Transferase Deficiency Galactosemia Transferase Deficient Galactosemia A disorder characterized by the body's inability to metabolize galactose. This type of galactosemia is caused by germline mutations in the GALT gene which leads to the inhibition in the activity of the enzyme galactose-1-phosphate uridyl transferase. C34816 Congenital Metabolic Disorder C89506 NICHD Newborn Screening Terminology C38038 Tremor Tremor The shaking movement of the whole body or just a certain part of it, often caused by problems of the neurons responsible for muscle action. Unintentional trembling or shaking of one or more body parts. C100104 Sign or Symptom C89506 NICHD Newborn Screening Terminology C17230 Ultrasonography Ultrasonography Ultrasound Imaging|Ultrasound A technique in which high-frequency sound waves are bounced off internal organs and the echo pattern is converted into a 2 dimensional picture of the structures beneath the transducer. C18020 Diagnostic Procedure C89506 NICHD Newborn Screening Terminology C87126 Umbilical Cord Prolapse Umbilical Cord Prolapse Prolapsed Cord A situation in which the umbilical cord is ahead of the presenting fetal part. If the cord becomes compressed it may cut off the flow of blood to the baby. Passage of the umbilical cord through the cervix before the fetus during delivery. C81236 Birth Complication C89506 NICHD Newborn Screening Terminology C12326 Undescended Testes Undescended Testes Undescended Testis The failure of one or both testes of a male fetus to descend from the abdomen into the scrotum during the late part of pregnancy. If not surgically corrected in early childhood, males may be at increased risk for testicular cancer later in life. C103185 Congenital Reproductive System Abnormality C27019 Male Reproductive System Disorder C89506 NICHD Newborn Screening Terminology C25709 Unit of Measure Unit of Measure A named quantity in terms of which other quantities are measured or specified, used as a standard measurement of like kinds. C20189 Property or Attribute C89506 NICHD Newborn Screening Terminology C77606 Unit per Gram Unit per Gram An arbitrary unit of substance content expressed in unit(s) per gram. C25709 Unit of Measure C89506 NICHD Newborn Screening Terminology C30010 US State US State One of the fifty states which is a member of the federation known as the United States of America. Other US geographic areas, such as Puerto Rico and the District of Columbia, are essentially equivalent to State when used in an address. C16495 Demographics C89506 NICHD Newborn Screening Terminology C81300 Vacuum Assisted Vaginal Delivery Vacuum Assisted Vaginal Delivery Application of a vacuum device to the fetal head to facilitate vaginal birth. Application of a vacuum device to the fetal head to facilitate vaginal birth. C81301 Vaginal Assisted Delivery C89506 NICHD Newborn Screening Terminology C81301 Vaginal Assisted Delivery Vaginal Assisted Delivery Birth of the fetus through the vagina with the application of vacuum or forceps or any other instrument. Birth of the fetus through the vagina with the application of vacuum or forceps or any other instrument. C81303 Vaginal Delivery C89506 NICHD Newborn Screening Terminology C81302 Vaginal Birth after Cesarean Delivery Vaginal Birth after Cesarean Delivery Vaginal Birth after Caesarean|Vaginal Birth after Cesarean A vaginal birth in a woman with one or more previous cesarean births. (reVITALize) A vaginal birth in a woman with one or more previous cesarean births. [verbatim from reVITALize] C81303 Vaginal Delivery C89506 NICHD Newborn Screening Terminology C81303 Vaginal Delivery Vaginal Delivery Birth of the fetus through the vagina. Birth of the fetus through the vagina. C81179 Delivery Procedure C89506 NICHD Newborn Screening Terminology C87127 Vasa Previa Vasa Previa Umbilical blood vessels that have inserted into the amniotic membrane (membranous insertion) that in turn are above or adjacent to the cervical os and are at risk of rupture. Umbilical blood vessels that have inserted into the amniotic membrane (membranous insertion) that in turn are above or adjacent to the cervical os and are at risk of rupture. C81236 Birth Complication C89506 NICHD Newborn Screening Terminology C81184 Vernier Caliper Vernier Caliper A medical device that is a combination of ruler and caliper that can measure the distance between two points. The configuration of this device permits the measurement of internal dimensions. An instrument for measuring external or internal dimensions. It consists of an L-shaped frame with a linear scale along its longer arm and an L-shaped sliding attachment with a vernier, used to read directly the dimension of an object represented by the separation between the inner or outer edges of the two shorter arms. C62103 C89506 NICHD Newborn Screening Terminology C12998 Vertebral Column Vertebral Column A series of bones, muscles, tendons, and other tissues reaching from the base of the skull to the tailbone. The vertebral column forms the axis of the skeleton and encloses as well as protects the spinal cord and the fluid surrounding the spinal cord. C32221 Body Part C89506 NICHD Newborn Screening Terminology C49672 Vital Signs Measurement Vital Sign Measurement The act of assessing an individual's current temperature, heart rate, respiratory rate, pulse oxygenation, and blood pressure. C18020 Diagnostic Procedure C89506 NICHD Newborn Screening Terminology C943 Vitamin K Vitamin K The term "vitamin K" refers to a group of chemically similar fat-soluble compounds called naphthoquinones: vitamin K1 (phytonadione) is found in plants and is the primary source of vitamin K for humans through dietary consumption, vitamin K2 compounds (menaquinones) are made by bacteria in the human gut, and vitamin K3 (menadione) is a water-soluble preparation available for adults only. Vitamin K is necessary for the liver to produce the coagulation factors II, VII, IX, and X, as well as the clotting factors protein C, protein S, and protein Z; vitamin K deficiency can result in deficiencies of these coagulation factors and excess bleeding. An injection of vitamin K is routinely given to newborn infants to prevent vitamin K deficiency bleeding, also known as hemorrhagic disease of the newborn. Vitamin K deficiency is rare in adults but may result from chronic malnutrition or an inability to absorb dietary vitamins. C1909 Pharmacologic Substance C89506 NICHD Newborn Screening Terminology C87129 Weak Breathing Weak Breathing Shallow inhalations and exhalations that indicate respiratory distress. C100104 Sign or Symptom C89506 NICHD Newborn Screening Terminology C78718 Wheezing Wheezing A symptom and a finding during physical examination, characterized by a high-pitched, whistling sound during breathing. It results from the narrowing or obstruction of the respiratory airways. The most common causes of wheezing are asthma, chronic obstructive pulmonary disease, tracheobronchitis, and pulmonary edema. A high-pitched breath sound resulting from a narrowing or obstruction of the small airways. C100104 Sign or Symptom C89506 NICHD Newborn Screening Terminology C87131 Yawning Yawning An involuntary deep inhalation with the mouth open, often a sign of drowsiness or boredom. C100104 Sign or Symptom C89506 NICHD Newborn Screening Terminology C49488 Yes Yes The affirmative response to a question. C25180 Indicator C89506 NICHD Newborn Screening Terminology C3368 Digestive System Signs and Symptoms Signs and symptoms associated with disturbances within the digestive system, which includes the stomach, intestines and all associated organs that aid in digestion. C100104 Sign or Symptom C90259 NICHD Pediatric Terminology C12664 Abdomen Abdomen The portion of the body that lies between the thorax and the pelvis. C32221 Body Part C90259 NICHD Pediatric Terminology C101191 Acquired Bilateral Cataracts Acquired Bilateral Cataracts Cataracts in both eyes that result from the aging process, an injury, or as a manifestation of a systemic disorder. C98802 Acquired Cataract C101193 Bilateral Cataracts C90259 NICHD Pediatric Terminology C34348 Acrocephalosyndactyly Acrocephalosyndactyly A genetic disorder characterized by craniosynostosis and fusion of the fingers and toes. C89337 Congenital Musculoskeletal Defect C3101 Genetic Disorder C90259 NICHD Pediatric Terminology C92621 Acute Stress Disorder Acute Stress Disorder An anxiety disorder precipitated by an experience of intense fear or horror while exposed to a traumatic (especially life-threatening) event. The disorder is characterized by dissociative symptoms; vivid recollections of the traumatic event; avoidance of stimuli associated with the traumatic event; and a constant state of hyperarousal for no more than one month. C2878 Anxiety Disorder C90259 NICHD Pediatric Terminology C25407 Address Address A standardized representation of the location of a person, business, building, or organization. C16495 Demographics C90259 NICHD Pediatric Terminology C39298 Adolescence Adolescence The time period between the beginning of puberty and adulthood. A human life stage that begins at twelve years of age and continues until twenty-one complete years of age, generally marked by the beginning of puberty and lasting to the beginning of adulthood. C89345 Childhood C90259 NICHD Pediatric Terminology C34362 Agoraphobia Agoraphobia An anxiety disorder characterized by an intense, irrational fear of venturing out into open places or situations in which help (or escape) might not be available should excessive anxiety or panic symptoms develop. C2878 Anxiety Disorder C90259 NICHD Pediatric Terminology C81229 Alcohol Use History Alcohol Use History A description of an individual's current and past experience with alcoholic beverage consumption. C18772 Personal Medical History C90259 NICHD Pediatric Terminology C62651 Allergen Allergen A substance that elicits an allergic reaction. C45306 Substance C90259 NICHD Pediatric Terminology C114476 Allergic Reaction Allergic Reaction An immune response that occurs following re-exposure to an innocuous antigen, and that requires the presence of existing antibodies against that antigen. This response involves the binding of IgE to mast cells, and may worsen with repeated exposures. A hypersensitivity reaction triggered by exposure to a previously encountered foreign substance to which the individual has formed antibodies. C3507 Immune System Disorder C90259 NICHD Pediatric Terminology C12219 Anatomic Structure, System, or Substance Anatomic Structure, System, or Substance A human biological structure, fluid or other substance; excludes single molecular entities. C89505 Prenatal and Pediatric Terminology C90259 NICHD Pediatric Terminology C15181 Anesthesia Procedure Anesthesia Procedure Treatment with a pharmacological substance that produces a loss of feeling. C25218 Intervention or Procedure C90259 NICHD Pediatric Terminology C32078 Ankle Joint Ankle Joint A gliding joint between the distal ends of the tibia and fibula and the proximal end of the talus. C32221 Body Part C90259 NICHD Pediatric Terminology C34387 Anorexia Nervosa Anorexia Nervosa A disorder most often seen in adolescent females characterized by a refusal to maintain a minimally normal body weight, an intense fear of gaining weight, a disturbance in body image, and, in postmenarcheal females, the development of amenorrhea. C89332 Eating Disorder C90259 NICHD Pediatric Terminology C2878 Anxiety Disorder Anxiety Disorder A category of psychiatric disorders which are characterized by anxious feelings or fear often accompanied by physical symptoms associated with anxiety. C2893 Psychiatric Disorder C90259 NICHD Pediatric Terminology C73437 Apgar Score Apgar Score APGAR Score The numerical sum between zero and ten that is computed from individual values of zero to two that are assigned to five different areas of interest in newborn screenings. These areas are breathing, muscle tone, pulse rate, reflex irritability and skin color. The numerical sum between zero and ten that is computed from individual values of zero to two that are assigned to five different areas of interest in newborn screenings. These areas are breathing, muscle tone, pulse rate, reflex irritability and skin color. C118807 C90259 NICHD Pediatric Terminology C81230 Apgar Test Apgar Test APGAR Test A test devised by Dr. Virginia Apgar to assess the overall health of a newborn upon birth. The test is administered at one and five minutes after birth and allows for the assignation of numerical values between zero and two for specific observations regarding skin color, pulse rate, reflex irritability, muscle tone and breathing. C84749 Newborn Examination C90259 NICHD Pediatric Terminology C32141 Arm Arm The portion of the upper extremity between the shoulder and the elbow. For clinical purposes this term is also used to refer to the whole superior limb. C32221 Body Part C90259 NICHD Pediatric Terminology C90496 Arm Recoil Test Arm Recoil Test Arm Recoil Measurement A test commonly administered to assess the physiologic response to extending the arms as straight as possible alongside the body when lying down. C84749 Newborn Examination C90259 NICHD Pediatric Terminology C2881 Arrhythmia Arrhythmia Cardiac Arrhythmia Any variation from the normal rate or rhythm (which may include the origin of the impulse and/or its subsequent propagation) in the heart. Any variation from the normal rate or rhythm (which may include the origin of the impulse and/or its subsequent propagation) in the heart.|Cardiac Arrhythmias are heart-rhythm problems - they occur when the electrical impulses to the heart that coordinate heartbeats are not working properly, making the heart beat too fast/slow or inconsistently. C78245 Cardiac Conduction Disorder C90259 NICHD Pediatric Terminology C97159 Asperger Syndrome Asperger Syndrome A disorder most often diagnosed in the pediatric years in which the individual displays marked impairment in social interaction and a repetitive, stereotyped pattern of behavior. The individual, however, displays no delay in language or cognitive development, which differentiates Asperger Syndrome from autism. C88412 Autism Spectrum Disorder C90259 NICHD Pediatric Terminology C97168 Ataxic Cerebral Palsy Ataxic Cerebral Palsy The least common subtype of cerebral palsy, in which the individual displays hypotonia, a loss of motor coordination, and an intention tremor. Individuals with ataxic cerebral palsy walk very unsteadily, with a wide-based gait. A type of cerebral palsy characterized by decreased muscle tone, a loss of motor coordination and an intention tremor. C34460 Cerebral Palsy C90259 NICHD Pediatric Terminology C97169 Athetoid Cerebral Palsy Athetoid Cerebral Palsy A subtype of cerebral palsy characterized by involuntary, purposeless writhing movements which affect the hands, feet, arms, and legs; the face and tongue may be affected as well, leading to involuntary grimacing, drooling, dysarthria and difficulty eating. A type of cerebral palsy characterized by involuntary, purposeless writhing movements that affect the hands, feet, arms, and legs; the face and tongue may be affected as well, leading to involuntary grimacing, drooling, dysarthria and difficulty eating. C34460 Cerebral Palsy C90259 NICHD Pediatric Terminology C81231 Attending Health Care Provider Attending Health Care Provider The individual assigned to be the primary care manager overseeing a patient's medical care during an episode of hospitalization. C25190 Person C90259 NICHD Pediatric Terminology C97160 Attention Deficit Hyperactivity Disorder Attention Deficit Hyperactivity Disorder A disorder characterized by a marked pattern of inattention and/or hyperactivity-impulsivity that is inconsistent with developmental level and clearly interferes with functioning in at least two settings (e.g. at home and at school). At least some of the symptoms must be present before the age of 7 years. A neurodevelopmental disorder presenting in early childhood that is characterized by chronic and excessive inattention, overactivity, and/or impulsivity. C35470 Behavioral Disorder C90259 NICHD Pediatric Terminology C62761 Attenuated Bacteria Vaccine Attenuated Bacteria Vaccine Attenuated Live Bacterial Vaccine Any vaccine created by reducing the virulence of bacteria but still keeping the bacteria viable (live). In the production of an attenuated vaccine, the infectious agent is altered so that it becomes harmless or less virulent. This is in contrast to those vaccines produced by "killing" the pathogen (inactivated vaccine). C97116 Attenuated Live Vaccine C90259 NICHD Pediatric Terminology C97116 Attenuated Live Vaccine Attenuated Live Vaccine Any vaccine created by reducing the virulence of the infectious agent but still keeping the agent viable (live). In the production of an attenuated vaccine, the infectious agent is altered so that it becomes harmless or less virulent. This is in contrast to those vaccines produced by killing the pathogen (inactivated vaccine). C923 Vaccine C90259 NICHD Pediatric Terminology C1920 Attenuated Live Virus Vaccine Attenuated Live Virus Vaccine Live vaccines prepared from microorganisms which have undergone physical adaptation (e.g., by radiation or temperature conditioning) or serial passage in laboratory animal hosts or infected tissue/cell cultures, in order to produce avirulent mutant strains capable of inducing protective immunity. Live-attenuated vaccines are used when a CD8+ T Cell (cellular cytotoxicity) response is desired. C97116 Attenuated Live Vaccine C90259 NICHD Pediatric Terminology C38036 Audiometric Test Audiometric Test Testing conducted utilizing a manual or microprocessor audiometer to test for hearing loss. C84749 Newborn Examination C90259 NICHD Pediatric Terminology C97161 Autism Autism A disorder characterized by marked impairments in social interaction and communication accompanied by a pattern of repetitive, stereotyped behaviors and activities. Developmental delays in social interaction and language surface prior to age 3 years. A neurodevelopmental disorder presenting in early childhood that is characterized by impaired communication, difficulty in social interactions, stereotypic behaviors, and a limited range of interests and activities. C88412 Autism Spectrum Disorder C90259 NICHD Pediatric Terminology C88412 Autism Spectrum Disorder Autism Spectrum Disorder A spectrum of developmental disorders that includes autism, Asperger syndrome, and Rett syndrome. Signs and symptoms include poor communication skills, defective social interactions, and repetitive behaviors. Neurodevelopmental disorders presenting in childhood with classic symptoms of impairment in verbal and nonverbal communication, social interactions, and/or imaginative play. C97179 Pervasive Developmental Disorder C90259 NICHD Pediatric Terminology C14187 Bacteria Bacteria Unicellular, prokaryotic organisms that reproduce by cell division and usually have cell walls; can be shaped like spheres, rods or spirals and can be found in virtually any environment. C14250 Organism C90259 NICHD Pediatric Terminology C2890 Bacterial Infection Bacterial Disease An acute infectious disorder caused by gram positive or gram negative bacteria. Representative examples include pneumococcal, streptococcal, salmonella and meningeal infections. C26726 Infectious Disease C90259 NICHD Pediatric Terminology C89512 Barlow's Maneuver Barlow's Maneuver Useful in assessing for developmental dysplasia of the hip, this test is performed when the thigh is pushed posteriorly and the hip is adducted. Should the hip become dislocated by this movement, the result is considered positive. C84749 Newborn Examination C90259 NICHD Pediatric Terminology C61454 Basilar Rales Basilar Rales Abnormal breath sounds (crackles) heard on auscultation only in the bases of the lungs. They indicate inflammation, fluid, or infection in the air sacs of the lung. C100104 Sign or Symptom C90259 NICHD Pediatric Terminology C81232 Bayley Scale of Infant Development I Bayley Scale of Infant Development I Bayley Scales of Infant Development The first edition of a standardized series of measurements that assesses the cognitive, motor, and behavioral development in infants and babies from one to twenty-four months of age. C81314 Newborn Behavioral Examination C90259 NICHD Pediatric Terminology C16326 Behavior Behavior The actions or reactions of an object or organism, usually in relation to the environment or surrounding world of stimuli. C19988 Organismal Process C90259 NICHD Pediatric Terminology C90346 Behavior during Childhood Behavior during Childhood Child Behavior Observed actions from individuals between 2 and 18 years of age. C16326 Behavior C90259 NICHD Pediatric Terminology C81234 Behavioral Assessment Behavioral Assessment Assessment of individual responses to age appropriate stimuli. C25214 Evaluation Procedure C90259 NICHD Pediatric Terminology C81233 Behavioral Development Behavioral Development The evolution of actions, including reactions and responses to the environment, over an individual's lifespan. C17770 Maturation C90259 NICHD Pediatric Terminology C35470 Behavioral Disorder Behavioral Disorder A specific behavioral problem that occurs in persistent patterns and characteristic clusters and that causes clinically significant impairment. C2991 Disease or Disorder C90259 NICHD Pediatric Terminology C81235 Behavioral Rating Scale Behavioral Rating Scale A range of values designed to quantify the qualitative responses of an individual to a set of challenges. C81314 Newborn Behavioral Examination C90259 NICHD Pediatric Terminology C97162 Binge Eating Binge Eating Recurrent episodes of over-eating. Binge eating with or without purging. C89332 Eating Disorder C90259 NICHD Pediatric Terminology C307 Biological Agent Biologic Agent Biotechnology-derived pharmaceutical agents made from living organisms or their products. Includes recombinant proteins, monoclonal antibodies, and nucleic acids. C1909 Pharmacologic Substance C90259 NICHD Pediatric Terminology C34423 Bipolar Disorder Bipolar Disorder A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence. C2893 Psychiatric Disorder C90259 NICHD Pediatric Terminology C81236 Birth Complication Birth Complication The development of a problematic medical situation that occurs concurrently with the birth of a neonate. C2959 Complication C90259 NICHD Pediatric Terminology C68615 Birth Date Birth Date The calendar date on which a person was born. C25164 Date C90259 NICHD Pediatric Terminology C81237 Birth Facility Birth Facility The facility which provides a setting with provisions for monitoring and delivering babies. C16495 Demographics C90259 NICHD Pediatric Terminology C81296 Birth Time Birth Time The hour, minute, and/or second at which birth occurs. C25207 Time C90259 NICHD Pediatric Terminology C76325 Birth Weight Birth Weight The first weight of a newborn obtained after birth. A measured weight of a newborn obtained immediately or shortly after birth. C81328 Body Weight C90259 NICHD Pediatric Terminology C97109 Blindness Blindness The lack of vision. It is caused by neurological or physiological factors. Profound visual impairment despite optimal refractive correction. C35126 Vision Disorder C90259 NICHD Pediatric Terminology C54706 Blood Pressure Blood Pressure The pressure of the circulating blood against the walls of the blood vessels. C25447 Characteristic C90259 NICHD Pediatric Terminology C81304 Blood Product Blood Product Any natural or synthetic composition that replicates the structure or function of a native component of blood. C13236 Body Fluid or Substance C90259 NICHD Pediatric Terminology C15192 Blood Transfusion Blood Transfusion The injection of whole blood or a blood component directly into the bloodstream. C49236 Therapeutic Procedure C90259 NICHD Pediatric Terminology C13236 Body Fluid or Substance Body Fluid or Substance Material produced by living organisms; it can be a necessary constituent of, or product of an organismal process. C45306 Substance C90259 NICHD Pediatric Terminology C32221 Body Part Body Part Any part of an organism. C12219 Anatomic Structure, System, or Substance C90259 NICHD Pediatric Terminology C81328 Body Weight Body Weight The weight of a subject. C25447 Characteristic C90259 NICHD Pediatric Terminology C76205 Bordetella pertussis Bordetella pertussis A species of bacteria within the phylum Proteobacteria consisting of gram-negative aerobic coccobacillus that are the causative agent of pertussis. C14187 Bacteria C90259 NICHD Pediatric Terminology C81305 Bottle Feeding Bottle Feeding Provision of liquid nutrition via a closed container system with a rubber like mouthpiece resembling a nipple. Delivery of enteral nutrition by a bottle. C81267 Feeding Method C90259 NICHD Pediatric Terminology C96412 Brain Development Abnormality Brain Development Abnormality A group of congenital or acquired disorders that affect the normal development of the brain. C89338 Neurodevelopmental Disorder C90259 NICHD Pediatric Terminology C96413 Brain Disorder Brain Disorder A non-neoplastic or neoplastic disorder that affects the brain. C2934 Central Nervous System Disorder C90259 NICHD Pediatric Terminology C81238 Brazelton Neonatal Behavioral Assessment Scale Brazelton Neonatal Behavioral Assessment Scale An assessment tool created by Dr. T. Berry Brazelton and his colleagues to assist caregivers in determining developmental strengths and weaknesses in infants from birth to the age of two months. C81314 Newborn Behavioral Examination C90259 NICHD Pediatric Terminology C25596 Breast Feeding Breast Feeding The nursing of an infant at the mother's breast. The nursing of an infant at the mother's breast. C16326 Behavior C90259 NICHD Pediatric Terminology C13257 Breast Milk Breast Milk Milk produced by female mammals for the purpose of feeding their young. C13236 Body Fluid or Substance C90259 NICHD Pediatric Terminology C81306 Breathing Effort Score Breathing Effort Score A component of the Apgar score, it is the numerical value assigned to the assessment of breathing effort by a neonate. 0 = no spontaneous respirations; 1 = slow or irregular respirations or a weak cry; 2 = strong, consistent respirations with a robust cry. A component of the Apgar score, it is the numerical value assigned to the assessment of the newborn's breathing effort. 0 = no spontaneous respirations; 1 = slow or irregular respirations or a weak cry; 2 = strong, consistent respirations with a robust cry. C118807 C90259 NICHD Pediatric Terminology C34440 Bulimia Nervosa Bulimia Nervosa A disorder characterized by recurrent episodes of binge-eating over which the individual feels a lack of control; these episodes of binge-eating are followed by recurrent compensatory behavior to prevent weight gain, usually self-induced vomiting. In addition, self-evaluation is unduly influenced by body image. Recurrent episodes of over-eating. C89332 Eating Disorder C90259 NICHD Pediatric Terminology C87067 Caput Succedaneum Caput Succedaneum A diffuse swelling of the scalp in a newborn, usually caused by the trauma of the scalp pushing through a narrowed cervix during birth. The swelling may extend across the midline of the scalp and may exhibit discoloration or bruising. A diffuse swelling of the scalp in a newborn, usually caused by the trauma of the scalp pushing through a narrowed cervix during birth. The swelling may extend across the midline of the scalp and may exhibit discoloration or bruising. C81236 Birth Complication C90259 NICHD Pediatric Terminology C2931 Cardiovascular Disorder Cardiovascular Disorder A non-neoplastic or neoplastic disorder affecting the heart or the vessels (arteries, veins and lymph vessels). Representative examples of non-neoplastic cardiovascular disorders are endocarditis and hypertension. Representative examples of neoplastic cardiovascular disorders are endocardial myxoma and angiosarcoma. C2991 Disease or Disorder C90259 NICHD Pediatric Terminology C81239 Cause of Death Cause of Death The circumstance or condition that results in the death of a living being. C3367 Finding C90259 NICHD Pediatric Terminology C81240 Cellular Telephone Number Cellular Telephone Number The sequence of numbers or characters, that when dialed, connects to a particular cellular telephone. C40978 Telephone Number C90259 NICHD Pediatric Terminology C49668 Centimeter Centimeter A basic unit of length in the former CGS version of metric system, equal to one hundredth of a meter or approximately 0.393 700 787 inch. C25709 Unit of Measure C90259 NICHD Pediatric Terminology C97170 Central Auditory Processing Disorder Central Auditory Processing Disorder A disorder characterized by impairment of the auditory processing, resulting in deficiencies in the recognition and interpretation of sounds by the brain. Causes include brain maturation delays and brain traumas or tumors. C97155 Language Disorder C90259 NICHD Pediatric Terminology C34662 Central Hearing Loss Central Hearing Loss Hearing loss resulting from disorders of the central nervous system auditory pathways. Hearing loss resulting from disorders of the central nervous system auditory pathways. C35731 Hearing Loss C90259 NICHD Pediatric Terminology C2934 Central Nervous System Disorder Central Nervous System Disorder A non-neoplastic or neoplastic disorder which affects the brain and/or spinal cord. C26835 Nervous System Disorder C90259 NICHD Pediatric Terminology C87124 Central Nervous System Signs and Symptoms Central Nervous System Signs and Symptoms Signs and symptoms associated with disturbances within the central nervous system, which includes the brain, spinal cord and meninges. C100104 Sign or Symptom C90259 NICHD Pediatric Terminology C50484 Cephalohematoma Cephalohematoma Cephalhematoma A subperiosteal hemorrhage limited to the surface of one cranial bone, a usually benign condition seen in the newborn as a result of bone trauma. A subperiosteal hemorrhage limited to the surface of one cranial bone. It is seen in the newborn and often related to the birthing process. C81236 Birth Complication C92719 Fetal Disorder C90259 NICHD Pediatric Terminology C34460 Cerebral Palsy Cerebral Palsy A group of disorders affecting the development of movement and posture, often accompanied by disturbances of sensation, perception, cognition, and behavior. It results from damage to the fetal or infant brain. A group of permanent disorders of the development of movement and posture, causing activity limitation, that are attributed to non-progressive disturbances in the developing fetal or infant brain.|A non-progressive, neurological syndrome presenting in infancy or early childhood that is caused by brain injury or malformation and is characterized by permanent impairment of muscle coordination and various movement disorders. C26835 Nervous System Disorder C89328 Pediatric Disorder C90259 NICHD Pediatric Terminology C9039 Cervical Carcinoma Cervical Carcinoma A carcinoma arising from either the exocervical squamous epithelium or the endocervical glandular epithelium. The major histologic types of cervical carcinoma are: squamous carcinoma, adenocarcinoma, adenosquamous carcinoma, adenoid cystic carcinoma and undifferentiated carcinoma. C9305 Cancer|Malignant Neoplasm C90259 NICHD Pediatric Terminology C3782 Cervical Intraepithelial Neoplasia Cervical Intraepithelial Neoplasia Squamous or glandular intraepithelial neoplasia that affects the cervical mucosal epithelium. There is no evidence of stromal invasion. According to the degree of cellular atypia and the associated architectural changes, it is classified as low or high grade. C3262 Neoplasm C90259 NICHD Pediatric Terminology C46088 Cesarean Section Cesarean Section C-Section|Caesarean Section Surgical delivery of one or more intrauterine fetuses though an abdominal incision. Surgical delivery of one or more intrauterine fetuses though an abdominal incision. C81179 Delivery Procedure C90491 C90259 NICHD Pediatric Terminology C25447 Characteristic Characteristic The distinguishing qualities or prominent aspect of a person, object, action, process, or substance. C20189 Property or Attribute C90259 NICHD Pediatric Terminology C97132 Chicken Pox Chicken Pox A contagious childhood disorder caused by the varicella zoster virus. It is transmitted via respiratory secretions and contact with chickenpox blister contents. It presents with a vesicular skin rush, usually associated with fever, headache, and myalgias. The pruritic fluid-filled vesicles occur 10-21 days after exposure and last for 3-4 days. An additional 3-4 days of malaise follows before the affected individual feels better. An individual is contagious 1-2 days prior to the appearance of the blisters until all blisters are crusted over. Generally, healthy individuals recover without complications. C96411 Pediatric Viral Infection C96407 Varicella Zoster Infection C90259 NICHD Pediatric Terminology C16423 Child Child A person who is not yet an adult. The specific cut-off age will vary by purpose. C25190 Person C90259 NICHD Pediatric Terminology C89345 Childhood Childhood Child Life Stage The time period between the beginning of infancy and the end of adolescence. A time period that begins at the beginning of the human embryonic stage and continues until the end of adolescence. C89335 Life Stage C90259 NICHD Pediatric Terminology C97163 Childhood Depression Childhood Depression Similar to depression in adults, childhood depression is characterized by a prolonged depressed or irritable mood accompanied by a significant loss of interest in activities, changes in appetite or sleep, decreased energy, feelings of worthlessness, and/or recurrent thoughts of death or suicide. C92190 Pediatric Psychiatric Disorder C90259 NICHD Pediatric Terminology C97164 Childhood Disintegrative Disorder Childhood Disintegrative Disorder A pediatric disorder characterized by normal development for at least the first two years of life followed by a severe regression in language, social interaction, bowel or bladder control, and/or motor skills. The affected individual may also exhibit repetitive and stereotyped patterns of behavior similar to autism. A neurodevelopmental disorder that presents between the ages of two and ten, and is characterized by severe regression of communication, social interactions, bowel or bladder control, and/or motor skills that has previously developed normally. C92190 Pediatric Psychiatric Disorder C97179 Pervasive Developmental Disorder C90259 NICHD Pediatric Terminology C84449 Childhood Obesity Childhood Obesity Having a high amount of body fat during childhood. C89328 Pediatric Disorder C90259 NICHD Pediatric Terminology C35004 Childhood Schizophrenia Childhood Schizophrenia Schizophrenia occurring in childhood. C92190 Pediatric Psychiatric Disorder C90259 NICHD Pediatric Terminology C25160 City City A large and densely populated urban area; a city specified in an address. C16495 Demographics C90259 NICHD Pediatric Terminology C87175 Cleft Lip Cleft Lip A congenital abnormality consisting of one or more clefts (splits) in the upper lip, which may be accompanied by a cleft palate; it is the result of the failure of the embryonic parts of the lip to fuse. C97171 Congenital Gastrointestinal Disorder C90259 NICHD Pediatric Terminology C87069 Cleft Palate Cleft Palate A congenital abnormality consisting of a fissure in the midline of the hard and/or soft palate; it is the result of the failure of the two sides of the palate to fuse during embryonic development. C97171 Congenital Gastrointestinal Disorder C90259 NICHD Pediatric Terminology C20993 Research or Clinical Assessment Tool Clinical Assessment Tool Any one of several evaluation/assessment tools used to ascertain a patient's condition or diagnosis. C25214 Evaluation Procedure C90259 NICHD Pediatric Terminology C34484 Clonus Clonus A form of involuntary muscular movement characterized by alternating contractions and relaxation in rapid succession. In the context of reflex testing, the ability to elicit clonus indicates injury to the nerve tracts above the point at which the reflex was initiated. C100104 Sign or Symptom C90259 NICHD Pediatric Terminology C34491 Clubbing of Fingers Clubbing of Fingers An abnormal enlargement of the terminal phalanges accompanied by increased length-wise curvature of the nails, giving the digits a club-like appearance. Clubbing has been noted with a wide variety of conditions, including pulmonary and cardiac diseases, liver disorders, and disorders of the gastrointestinal tract. C100104 Sign or Symptom C90259 NICHD Pediatric Terminology C84641 Clubfoot Clubfoot The most common congenital deformation of the foot, occurring in 1 of 1,000 live births. The most common form is talipes equinovarus, where the deformed foot is turned downward and inward sharply. A congenital malformation involving one or both feet, in which the affected foot is rotated inward and downward. C84978 Osteochondrodysplasia|Skeletal Dysplasia C90259 NICHD Pediatric Terminology C62736 Cognitive Assessment Cognitive Assessment The examination of the cognitive capacities or deficits of an individual through the application of tests that probe that individual's ability to perform various mental activities such as perception, learning, and reasoning. C81313 Neurologic Examination C90259 NICHD Pediatric Terminology C81241 Cognitive Development Cognitive Development The evolution of an individual's problem solving skills, memory, language development, and ability to process information about their environment. C17770 Maturation C90259 NICHD Pediatric Terminology C81286 Collection Date Collection Date The date on which the sample or data was collected. C25164 Date C90259 NICHD Pediatric Terminology C81287 Collection Time Collection Time The hour, minute, and/or second at which the sample or data was collected. C25207 Time C90259 NICHD Pediatric Terminology C89329 Conduct Disorder Conduct Disorder A disorder diagnosed in childhood or adolescence age group characterized by aggressive behavior, deceitfulness, destruction of property or violation of rules that is persistent and repetitive, and within a one year period. C35470 Behavioral Disorder C90259 NICHD Pediatric Terminology C27645 Conductive Hearing Loss Conductive Hearing Loss Hearing loss caused by impaired transmission of signals from the external auditory canal or middle ear to the cochlea. Hearing loss caused by impaired transmission of signals from the external auditory canal or middle ear to the cochlea. C35731 Hearing Loss C90259 NICHD Pediatric Terminology C2960 Condyloma Acuminatum Condyloma Acuminatum Condyloma Acuminatum|Genital Warts A sexually transmitted papillary growth caused by the human papillomavirus. It usually arises in the skin and mucous membranes of the perianal region and external genitalia. C3439 Viral Infection C90259 NICHD Pediatric Terminology C37928 Confusion Confusion A mental state characterized by a lack of clear and orderly thought and behavior. Impaired orientation to person, place or time. C87124 Central Nervous System Signs and Symptoms C90259 NICHD Pediatric Terminology C2849 Congenital Abnormality Congenital Abnormality Any abnormality, anatomical or biochemical, evident at birth or during the neonatal period. A morphologic defect of an organ, part of an organ, or larger region of the body that results from an intrinsically abnormal developmental process during gestation. C36287 C89328 Pediatric Disorder C90259 NICHD Pediatric Terminology C35729 Congenital Cardiovascular Abnormality Congenital Abnormality of the Circulatory System A heart or vascular abnormality which is inborn or present at birth. C2931 Cardiovascular Disorder C2849 Congenital Abnormality|Congenital Malformation C90259 NICHD Pediatric Terminology C87077 Congenital Ankyloblepharon Congenital Ankyloblepharon Fused Eyelid A congenital abnormality in which the margins of the upper and lower eyelids are fused together by bands of tissue. A finding in extremely premature newborns in which the normal epithelial adhesions connecting the upper and lower eyelids have not yet degraded. C99208 Eye Finding C90259 NICHD Pediatric Terminology C103172 Congenital Bleeding Disorder Congenital Bleeding Disorder Congenital Bleeding Defect|Congenital Coagulation Defect A bleeding disorder that is diagnosed during childhood, with the presenting symptom of excessive bleeding. C2902 Coagulation Defect|Coagulopathy C104003 Congenital Hematological Disorder C90259 NICHD Pediatric Terminology C97171 Congenital Digestive System Disorder Congenital Gastrointestinal Disorder Congenital Abnormality of the Digestive System An abnormality of the digestive system that is present at birth or detected in the neonatal period. C2849 Congenital Abnormality|Congenital Malformation C2990 Gastrointestinal Disorder C90259 NICHD Pediatric Terminology C35107 Congenital Genitourinary Abnormality Congenital Genitourinary Abnormality Congenital Abnormality of the Genitourinary System An abnormality of the genitourinary system that is present at birth or detected in the neonatal period. C2849 Congenital Abnormality|Congenital Malformation C90259 NICHD Pediatric Terminology C104003 Congenital Hematological Disorder Congenital Hematological Disorder A disorder of the blood that is present at birth. C2849 Congenital Abnormality|Congenital Malformation C26323 Hematologic Disorder C90259 NICHD Pediatric Terminology C26734 Congenital Hypothyroidism Congenital Hypothyroidism A deficiency of thyroid hormone present at birth. The etiology can be genetic or environmental, or a combination of both; treatment is based on severity and causality. C34816 Congenital Metabolic Disorder C90259 NICHD Pediatric Terminology C34816 Congenital Metabolic Disorder Congenital Metabolic Disorder A group of disorders present at birth that involve genetic defects leading to disturbances in carbohydrate, lipid, lysosomal storage or amino acid metabolism in the body. C3235 Metabolic Disease C97151 Congenital Systemic Disorder C90259 NICHD Pediatric Terminology C89337 Congenital Musculoskeletal Defect Congenital Musculoskeletal Defect Congenital Abnormality of the Musculoskeletal System An abnormality of the musculoskeletal system that is present at birth or detected in the neonatal period. C2849 Congenital Abnormality|Congenital Malformation C107377 Musculoskeletal System Disorder C90259 NICHD Pediatric Terminology C97172 Congenital Nervous System Disorder Congenital Nervous System Disorder Congenital Abnormality of the Nervous System An abnormality of the nervous system that is present at birth or detected in the neonatal period. C2849 Congenital Abnormality|Congenital Malformation C26835 Nervous System Disorder C90259 NICHD Pediatric Terminology C97173 Congenital Respiratory System Disorder Congenital Respiratory System Disorder Congenital Abnormality of the Respiratory System An abnormality of the respiratory system that is present at birth or detected in the neonatal period. C2849 Congenital Abnormality|Congenital Malformation C26871 Respiratory System Disorder C90259 NICHD Pediatric Terminology C97174 Congenital Skin Disorder Congenital Skin Disorder Congenital Abnormality of the Skin A skin abnormality that is present at birth or detected in the neonatal period. C2849 Congenital Abnormality|Congenital Malformation C3371 Skin Disorder C90259 NICHD Pediatric Terminology C97151 Congenital Systemic Disorder Congenital Systemic Disorder An inherited disorder that presents with systemic manifestations. An inherited disorder that affects in multiple tissue types or in multiple organ systemsis, or affects the body as a whole. C2849 Congenital Abnormality|Congenital Malformation C90259 NICHD Pediatric Terminology C1455 Conjugate Vaccine Conjugate Vaccine A category of vaccines created by covalently attaching an antigen from an organism to a carrier protein from the same organism to aid in the delivery of the immunogen. C97125 Polysaccharide Vaccine C90259 NICHD Pediatric Terminology C390 Contrast Agent Contrast Agent Substances administered during imaging procedures that allows delineation of internal structures. Contrast agents appear opaque due to the difference in absorption of X-rays or other electromagnetic waves and surrounding tissue. C1909 Pharmacologic Substance C90259 NICHD Pediatric Terminology C81242 Crown to Rump Length Measurement Crown to Rump Length Measurement A measurement from the high prominence of the head to the low prominence of the buttocks of a fetus or embryo during ultrasound. This measurement is useful in determining gestational age. A measurement from the high prominence of the head to the low prominence of the buttocks of a fetus or embryo during ultrasound. C81253 Gestational Age|Gestational Weeks Assessment C90259 NICHD Pediatric Terminology C26737 Cyanosis Cyanosis A bluish or purplish discoloration of the skin and mucous membranes resulting from a reduced amount of oxygenated hemoglobin in the blood. C100104 Sign or Symptom C90259 NICHD Pediatric Terminology C87065 Cyanotic Body Cyanotic Body Blue- or purplish-colored body; this is caused by excessive amounts of deoxygenated hemoglobin in the skin vessels of the body. C26737 Cyanosis C90259 NICHD Pediatric Terminology C87066 Cyanotic Limbs Cyanotic Limbs Blue- or purplish-colored limbs; this is caused by excessive amounts of deoxygenated hemoglobin in the skin vessels of the limbs. C26737 Cyanosis C90259 NICHD Pediatric Terminology C2978 Cyst Cyst A sac-like closed membranous structure that may be empty or contain fluid or amorphous material. C36287 C90259 NICHD Pediatric Terminology C3724 Cystic Hygroma Cystic Hygroma Cystic Lymphangioma A benign lymphatic neoplasm usually arising from the neck and characterized by cystic dilation of the lymphatic vessels. C2978 Cyst C3262 Neoplasm C90259 NICHD Pediatric Terminology C25164 Date Date The particular day, month and year an event has happened or will happen. C21514 Temporal Qualifier C90259 NICHD Pediatric Terminology C27644 Deafness Deafness An inherited or acquired condition characterized by the inability to hear in one or both ears. Inability to hear. C35731 Hearing Loss C90259 NICHD Pediatric Terminology C81244 Deceased Sibling Deceased Sibling The historical fact that a legal or consanguineous brother or sister has died. C90491 C90259 NICHD Pediatric Terminology C81179 Delivery Procedure Delivery Procedure Description of the method by which a fetus is delivered. C89340 C90259 NICHD Pediatric Terminology C16495 Demographics Demographics The statistical characterization of human populations or segments of human populations (e.g., characterization by age, sex, race, or income). C20189 Property or Attribute C90259 NICHD Pediatric Terminology C34527 Demyelinating Disorder Demyelinating Disorder A broad group of disorders that affect the myelin sheaths that cover the neurons. Myelin sheathes cover neuronal axons in the central and peripheral nervous system and function to increase travelling impulse speeds. Disruption of this sheath impairs neuronal transmission and can result in disorders such as multiple sclerosis and Guillain-Barre syndrome, among others. C26835 Nervous System Disorder C90259 NICHD Pediatric Terminology C81245 Denver Development Screening Test Denver Development Screening Test A test developed at the University of Colorado Medical Center to assess the developmental status of infants and children from birth to six years of age. C84749 Newborn Examination C90259 NICHD Pediatric Terminology C9011 Dermoid Cyst Dermoid Cyst A mature teratoma characterized by the presence of a cyst which is lined by mature tissue resembling the epidermis and the epidermal appendages. It occurs in the ovary, testis, and extragonadal sites including central nervous system and skin. A benign hamartomatous tumor that possesses various epidermal derivatives and is due to sequestration of skin along the lines of embryonic closure. In neonates, it is most commonly congenital and located in the subcutaneous tissues of the head, neck, or trunk. C2978 Cyst C90259 NICHD Pediatric Terminology C92561 Developmental Coordination Disorder Developmental Coordination Disorder Developmental Dyspraxia A disorder characterized by an impairment in the development of an individual's motor coordination skills; this impairment in motor development is not due to a medical condition. A developmental disorder characterized by voluntary motor skill impairment. C89338 Neurodevelopmental Disorder C90259 NICHD Pediatric Terminology C89330 Developmental Disorder Developmental Disorder A disorder diagnosed in childhood that is marked by either physical or mental impairment or both, which in turn affects the child from achieving age related developmental milestones. C89328 Pediatric Disorder C90259 NICHD Pediatric Terminology C90342 Developmental Milestone Developmental Milestone Developmental Milestones Physical or behavioral signs of maturation or skills gained by a developing child, which should be achieved by a given age that provide important information regarding the child's development. The milestones are different for each age range. Failure to achieve a particular milestone by a given age is indicative of developmental delay. C3367 Finding C90259 NICHD Pediatric Terminology C84669 Dextrocardia Dextrocardia A rare congenital abnormality in which the heart is located in the right side of the chest. It is associated with other congenital heart defects. C95834 Congenital Heart Disease C90259 NICHD Pediatric Terminology C15220 Diagnosis Diagnosis The investigation, analysis and recognition of the presence and nature of disease, condition, or injury from expressed signs and symptoms; also, the scientific determination of any kind; the concise results of such an investigation. C3367 Finding C90259 NICHD Pediatric Terminology C18020 Diagnostic Procedure Diagnostic Procedure Any procedure or test to diagnose a disease or disorder. C25218 Intervention or Procedure C90259 NICHD Pediatric Terminology C34687 Diaphragmatic Hernia Diaphragmatic Hernia A congenital or acquired weakness or opening in the diaphragm which allows abdominal contents to protrude into the chest cavity; congenital diaphragmatic hernias are caused when the embryonic diaphragm fails to fuse. C34685 Hernia C90259 NICHD Pediatric Terminology C2987 Diarrhea Diarrhea Watery bowel movements. Watery bowel movements. C3368 Gastrointestinal System Signs and Symptoms C90259 NICHD Pediatric Terminology C34541 Diphtheria Diphtheria A Gram-positive bacterial infection caused by Corynebacterium diphtheria. It usually involves the oral cavity, pharynx, and nasal cavity. Patients develop pseudomembranes in the affected areas and manifest signs and symptoms of an upper respiratory infection. The diphtheria toxin may cause myocarditis, polyneuritis, and other systemic effects. C2890 Bacterial Disease C90259 NICHD Pediatric Terminology C91718 Diphtheria Toxoid/Tetanus Toxoid Vaccine Adsorbed Diphtheria Toxoid/Tetanus Toxoid Vaccine Adsorbed A vaccine containing detoxified tetanus toxoid and detoxified diphtheria toxoid adsorbed on aluminum phosphate with active immunizing activity against diphtheria and tetanus. Intramuscular injection with this vaccine activates the immune system to develop antibodies against tetanus toxin and diphtheria toxin. C96398 Toxoid Vaccine C90259 NICHD Pediatric Terminology C91717 Diphtheria Toxoid/Tetanus Toxoid/Acellular Pertussis Vaccine Adsorbed Diphtheria Toxoid/Tetanus Toxoid/Acellular Pertussis Vaccine DTP vaccine|Diphtheria Toxoid Tetanus Toxoid Acellular Pertussis Vaccine Adsorbed A vaccine containing detoxified tetanus toxoid, detoxified diphtheria toxoid and acellular pertussis antigens, adsorbed on aluminum phosphate, with active immunizing activity against diphtheria, tetanus and pertussis. The acellular pertussis vaccine components, produced by Bordetella pertussis, are detoxified pertussis toxin (PT), filamentous hemagglutinin (FHA), pertactin (PRN) and fimbriae types 2 and 3 (FIM). Intramuscular injection with this vaccine activates the immune system to develop antibodies against tetanus toxin, diphtheria toxin and B. pertussis antigens. C2848 Polyvalent Vaccine C90259 NICHD Pediatric Terminology C97122 Diphtheria Toxoid/Tetanus Toxoid/Inactivated Pertussis Vaccine Diphtheria Toxoid/Tetanus Toxoid/Inactivated Pertussis Vaccine DTP A vaccine containing detoxified tetanus toxoid, detoxified diphtheria toxoid and inactivated pertussis antigens. C2848 Polyvalent Vaccine C90259 NICHD Pediatric Terminology C2991 Disease or Disorder Disease or Disorder Any abnormal condition of the body or mind that causes discomfort, dysfunction, or distress to the person affected or those in contact with the person. The term is often used broadly to include injuries, disabilities, syndromes, symptoms, deviant behaviors, and atypical variations of structure and function. C89505 Prenatal and Pediatric Terminology C90259 NICHD Pediatric Terminology C81273 Doctor's Information Doctor's Information A collection of information about a patient's doctor. C18772 Personal Medical History C90259 NICHD Pediatric Terminology C81246 Drug Use History Drug Use History A description of an individual's current and past use and/or abuse of drugs and chemicals. This includes prescription medication, illicit drugs and recreational substances. C18772 Personal Medical History C90259 NICHD Pediatric Terminology C81282 Dubowitz Score Dubowitz Score Ballard/Dubowitz Score The numerical value that represents a clinical assessment of neurological and physical criteria, performed between birth and five days of age, to determine an infant's gestational age and maturity. C118807 C90259 NICHD Pediatric Terminology C97165 Dyscalculia Dyscalculia A wide group of related learning disorders characterized by difficulties with mathematics and manipulating numbers; the difficulty with math may be caused or exacerbated by visuo-spatial or language processing difficulties. C89334 Learning Disorder C90259 NICHD Pediatric Terminology C96410 Dyslexia Dyslexia A learning disorder characterized by an impairment in processing written words. Reading difficulties can include distortions, omissions or substitutions of characters. Oral and silent reading difficulties can include faulty and slow comprehension. C89334 Learning Disorder C90259 NICHD Pediatric Terminology C12394 Ear Ear A sense organ needed for the detection of sound and for establishing balance. The outer ear consists of the auricle, the ear canal as well as the tympanic membrane. The middle ear is made up of an air-filled cavity behind the tympanic membrane that contains the ossicles (malleus, incus and stapes). The inner ear is made up of the cochlea needed for hearing and the vestibular apparatus required for balance. C32221 Body Part C90259 NICHD Pediatric Terminology C87071 Ear Dimple Ear Dimple A pit or dimple in front of the ear of a newborn is a common finding; rarely, such a dimple may get infected, which will be manifested with redness and swelling and will require medical attention. C100104 Sign or Symptom C90259 NICHD Pediatric Terminology C89331 Early Adolescence Early Adolescence A transitional time in an individual's life between childhood and adolescence. This phase marks the start of physical, physiological and psychological changes that characterize pubertal growth and development. A human life stage that begins at twelve years of age and continues until eighteen complete years of age. This phase marks the start of physical, physiological and psychological changes that characterize pubertal growth and development. C39298 Adolescence C90259 NICHD Pediatric Terminology C89346 Early Childhood Early Childhood A time period in a child's life that is accepted to be approximately between 1 and 5 years of age. A human life stage that begins at two years of age and continues until five complete years of age. C89345 Childhood C90259 NICHD Pediatric Terminology C89332 Eating Disorder Eating Disorder A broad group of psychological disorders with abnormal eating behaviors leading to physiological effects from overeating or insufficient food intake. C2893 Psychiatric Disorder C90259 NICHD Pediatric Terminology C97166 Echolalia Echolalia A symptom of neurologic or psychiatric dysfunction in which the individual involuntarily and meaninglessly repeats a recently heard word, series of words, or a song. Involuntarily repeating of other peoples words. C97170 Central Auditory Processing Disorder C90259 NICHD Pediatric Terminology C87167 Eclampsia Eclampsia A potentially life-threatening pregnancy-related disorder characterized by tonic-clonic seizures in association with hypertension after the twentieth week of gestation and up to six weeks postpartum and in the absence of other potential causes of seizures. A potentially life-threatening pregnancy-related disorder characterized by tonic-clonic seizures in association with hypertension after the twentieth week of gestation and up to six weeks postpartum and in the absence of other potential causes of seizures. C35169 Pregnancy Disorder C90259 NICHD Pediatric Terminology C17953 Education Level Education Level An indication of the years of schooling completed in graded public, private, or parochial schools, and in colleges, universities, or professional schools. C16495 Demographics C90259 NICHD Pediatric Terminology C32497 Elbow Joint Elbow Joint A type of hinge joint located between the forearm and upper arm. C32221 Body Part C90259 NICHD Pediatric Terminology C81326 Elevated Test Result Elevated Test Result A result of a test that is higher than a previous value or a normal range of values. C36292 Laboratory Test Result C90259 NICHD Pediatric Terminology C99135 Embryonic Stage Embryonic Stage A stage of life in which an embryo is developing. The stage terminates with the complete formation of the embryo. A human life stage, during prenatal development, that begins at fertilization and typically continues until the end of eight weeks after fertilization, with full formation of the embryo. C89335 Life Stage C90259 NICHD Pediatric Terminology C84687 Encephalocele Encephalocele A congenital neural tube closure defect resulting in the protrusion of the brain through a skull opening. When the protrusion includes the meninges, the term encephalomeningocele is used. C84923 Neural Tube Defect C90259 NICHD Pediatric Terminology C26920 Encephalopathy Encephalopathy A functional and/or structural disorder of the brain caused by diseases (e.g. liver disease, kidney disease), medications, chemicals, and injuries. Diffuse disease of the brain that alters function and/or structure of the brain and is characterized by an altered mental state. C96413 Brain Disorder C90259 NICHD Pediatric Terminology C3009 Endocrine System Disorder Endocrine System Disorder A non-neoplastic or neoplastic disorder that affects the endocrine system. Representative examples of non-neoplastic disorders include diabetes mellitus, hyperthyroidism, and adrenal gland insufficiency. Representative examples of neoplastic disorders include carcinoid tumor, neuroendocrine carcinoma, and pheochromocytoma. C2991 Disease or Disorder C90259 NICHD Pediatric Terminology C15642 Epidural Block Epidural Block An anesthetic procedure that involves administering pharmaceutical agents into the epidural space of the spinal canal. Frequently administered agents include local anesthetics and analgesics. C64381 Regional Anesthesia Procedure C90259 NICHD Pediatric Terminology C87072 Esophageal Atresia Esophageal Atresia A congenital abnormality of the esophagus in which the upper esophagus ends as a blind pouch and does not connect with the lower esophagus; it is often accompanied by a tracheoesophageal fistula. Signs and symptoms in a newborn with this abnormality include excessive salivation, choking, coughing, and the development of cyanosis and respiratory distress when fed. C97171 Congenital Gastrointestinal Disorder C90259 NICHD Pediatric Terminology C16564 Ethnic Group Ethnic Group A social group characterized by a distinctive social and cultural tradition that is maintained from generation to generation. Members share a common history and origin and a sense of identification with the group. They have similar and distinctive features in their lifestyle habits and shared experiences. They often have a common genetic heritage which may be reflected in their experience of health and disease. C16495 Demographics C90259 NICHD Pediatric Terminology C87073 Excessive Sucking Excessive Sucking A symptom of gastrointestinal dysfunction seen in neonates who have been exposed to drugs during pregnancy; often accompanied by excessive sucking of fists, fingers and thumbs. C100104 Sign or Symptom C90259 NICHD Pediatric Terminology C34599 Excoriation Excoriation Self-inflicted tearing or wearing off of skin. Self-inflicted tearing or wearing off of skin. C36281 Integumentary System Finding C100104 Sign or Symptom C90259 NICHD Pediatric Terminology C81247 Expected Date of Confinement Expected Date of Confinement The best estimated due date is determined by: last menstrual period (LMP) if confirmed by early ultrasound or no ultrasound performed, or early ultrasound if no known LMP or the ultrasound is not consistent with LMP, or known date of fertilization (e.g. Assisted Reproductive Technology (ART), Intrauterine Insemination (IUI)). Notes: 1. Ultrasound margin of error and "early" to be defined by SMFM/ACOG/NICHD workshop. 2. Pregnancy should not be re-dated by a later ultrasound after a best obstetrical estimate of EDD has been established. (adapted from reVITALize) The best estimated due date is determined by: last menstrual period (LMP) if confirmed by early ultrasound or no ultrasound performed, or early ultrasound if no known LMP or the ultrasound is not consistent with LMP, or known date of fertilization (e.g. Assisted Reproductive Technology (ART), Intrauterine Insemination (IUI)). C25164 Date C90259 NICHD Pediatric Terminology C12401 Eye Eye The organ of sight or vision. C32221 Body Part C90259 NICHD Pediatric Terminology C87074 Eye Prophylaxis Eye Prophylaxis The practice of placing antibiotic eye drops or ointment in a neonate's eyes after birth. C49236 Therapeutic Procedure C90259 NICHD Pediatric Terminology C81267 Feeding Method Feeding Method A description of the technique for the manner in which a subject is administered food. The technique for delivery of enteral nutrition. C3367 Finding C90259 NICHD Pediatric Terminology C16576 Female Female A person who belongs to the sex that normally produces ova. The term is used to indicate biological sex distinctions, or cultural gender role distinctions, or both. C28421 Sex C90259 NICHD Pediatric Terminology C27020 Female Reproductive System Disorder Female Reproductive System Disorder A non-neoplastic or neoplastic disorder that affects the female genital system. Representative examples of non-neoplastic disorders include infection, endometriosis, and adenomyosis. Representative examples of neoplastic disorders include germ cell tumors, carcinoma, lymphoma, and sarcoma. C4875 Reproductive System Disorder C90259 NICHD Pediatric Terminology C89885 Fetal Stage Fetal Stage The period during which an embryo is a fetus until birth. A human life stage, during prenatal development, that typically begins at the beginning of nine weeks after fertilization (full formation of the embryo) and continues until birth. C89335 Life Stage C90259 NICHD Pediatric Terminology C13235 Fetus Fetus An unborn or unhatched vertebrate in the later stages of development showing the main recognizable features of the mature being. C25190 Person C90259 NICHD Pediatric Terminology C3038 Fever Fever Elevation of body temperature above normal due to inflammatory or immune responses. Elevation of body temperature above normal due to the production of more heat than the body is able to dissipate. C50589 Hyperthermia C90259 NICHD Pediatric Terminology C3367 Finding Finding Clinical, laboratory or molecular evidence, or absence of evidence of disease. C89505 Prenatal and Pediatric Terminology C90259 NICHD Pediatric Terminology C89343 Finnegan Score Measurement Finnegan Score Measurement A tool to evaluate neonatal abstinence syndrome (NAS), that measures the degree to which a neonate is experiencing symptoms of withdrawal due to maternal substance abuse. C89515 Neonatal Abstinence Syndrome Assessment C90259 NICHD Pediatric Terminology C81272 First Feeding First Feeding The first time that a neonate is provided nutrition. C25207 Time C90259 NICHD Pediatric Terminology C81228 Five Minutes After Birth Five Minutes After Birth The actual time that is five minutes after the birth of a fetus. This period is most commonly referenced during the administration of the Apgar test. C25207 Time C90259 NICHD Pediatric Terminology C32621 Fontanelle Fontanelle The four gaps in the skull of a neonate or fetus where the sutures converge. The bulging or depression of the membranous soft spots can be indicative of intracranial fluid buildup or systemic dehydration. C32221 Body Part C90259 NICHD Pediatric Terminology C32622 Foot Foot The structure found below the ankle joint required for locomotion. C32221 Body Part C90259 NICHD Pediatric Terminology C81248 Forceps Delivery Forceps Delivery Application of forceps to the fetal head to facilitate vaginal birth. Application of forceps to the fetal head to facilitate vaginal birth. C81301 Vaginal Assisted Delivery C90259 NICHD Pediatric Terminology C87076 Frenulum Frenulum A small fold of tissue that limits the movements of an organ or body part; for example, the lingual frenulum connects the tongue to the floor of the mouth and restrains its movement. C32221 Body Part C90259 NICHD Pediatric Terminology C89887 Full Term Neonatal Stage Full Term Neonatal Stage Neonatal Stage|Term Neonatal Stage A human life stage that begins at full term birth and continues until twenty-seven complete days of age. A human life stage that begins at full term birth and continues until twenty-seven complete days of age. C89345 Childhood C90259 NICHD Pediatric Terminology C81308 Galactose Measurement Galactose Measurement The measurement of the amount of galactose in a biologic specimen. C49286 Hematology Test C90259 NICHD Pediatric Terminology C81251 Galactose-1-Phosphate Uridyltransferase Measurement Galactose-1-Phosphate Uridyltransferase Measurement The measurement of the galactose-1-phosphate uridyltransferase in a biologic specimen. C25294 Laboratory Procedure C90259 NICHD Pediatric Terminology C90497 Galeazzi Test Galeazzi Test An assessment for developmental dysplasia of the hip or a leg-length discrepancy, the patient is placed in a supine position and the ankles are brought to the buttocks with the hips and knees flexed. The result is considered positive when the knees are at different heights. C84749 Newborn Examination C90259 NICHD Pediatric Terminology C34632 Gastroenteritis Gastroenteritis An inflammatory disorder that affects the upper and lower gastrointestinal tract. Most commonly, this is attributed to viruses; however bacteria, parasites or adverse reactions can also be the culprit. Symptoms include acute diarrhea and vomiting. Inflammation of the stomach and small intestine. C2990 Gastrointestinal Disorder C90259 NICHD Pediatric Terminology C2990 Digestive System Disorder Gastrointestinal Disorder A non-neoplastic or neoplastic disorder that affects the gastrointestinal tract, anus, liver, biliary system, and pancreas. C2991 Disease or Disorder C90259 NICHD Pediatric Terminology C64380 General Anesthesia Procedure General Anesthesia Procedure Actions that render a patient unconscious for the purpose of performing a diagnostic or interventional procedure. C15181 Anesthesia Procedure C90259 NICHD Pediatric Terminology C87079 General Appearance General Appearance The result of observation and overall assessment of a subject's outward aspect including appearance and movements; for example, in a human newborn general appearance includes skin color and tone, range of motion, and spontaneous movements. C25447 Characteristic C90259 NICHD Pediatric Terminology C92622 Generalized Anxiety Disorder Generalized Anxiety Disorder An anxiety disorder characterized by excessive and difficult-to-control worry about a number of life situations. The worry is accompanied by restlessness, fatigue, inability to concentrate, irritability, muscle tension, and/or sleep disturbance and lasts for at least 6 months. C2878 Anxiety Disorder C90259 NICHD Pediatric Terminology C3101 Genetic Disorder Genetic Disorder Genetic diseases are diseases in which inherited genes predispose to increased risk. The genetic disorders associated with cancer often result from an alteration or mutation in a single gene. The diseases range from rare dominant cancer family syndrome to familial tendencies in which low-penetrance genes may interact with other genes or environmental factors to induce cancer. Research may involve clinical, epidemiologic, and laboratory studies of persons, families, and populations at high risk of these disorders. C2991 Disease or Disorder C90259 NICHD Pediatric Terminology C15709 Genetic Testing Genetic Testing The process of isolating and testing the DNA of an embryo or a person to detect the presence of genetic alterations or defects that may predispose to the future development of a disease or disorder. C25294 Laboratory Procedure C90259 NICHD Pediatric Terminology C25177 Genitalia Genitalia The external sex organs. C32221 Body Part C90259 NICHD Pediatric Terminology C81252 Gesell Developmental Schedule Gesell Developmental Schedule A scale used as an instrument to assess a child's motor and language development, as well as personal-social and adaptive behaviors. C81314 Newborn Behavioral Examination C90259 NICHD Pediatric Terminology C81253 Gestational Weeks Assessment Gestational Weeks Assessment Gestational age (written with both weeks and days, e.g. 39 weeks and 0 days) is calculated using the best obstetrical estimated due date (EDD) based on the following formula: Gestational Age = (280 - (EDD - Reference Date))/ 7. Note: Reference Date is the date on which you are trying to determine gestational age. (reVITALize) Gestational age (written with both weeks and days, e.g. 39 weeks and 0 days) is calculated using the best obstetrical estimated due date (EDD) based on the following formula: Gestational Age = (280 - (EDD - Reference Date))/ 7. Note: Reference Date is the date on which you are trying to determine gestational age. [verbatim from reVITALize] C89335 Life Stage C90341 Pediatric Intervention or Procedure C90259 NICHD Pediatric Terminology C26785 Goiter Goiter Enlargement of the thyroid gland usually caused by lack of iodine in the diet, hyperthyroidism, or thyroid nodules. Symptoms include difficulty in breathing and swallowing. C3009 Endocrine System Disorder C26836 Nutritional Disorder C90259 NICHD Pediatric Terminology C48155 Gram Gram The metric unit of mass equal to one thousandth of a kilogram. One gram equals approximately 15.432 grains or 0.035 273 966 ounce. C25709 Unit of Measure C90259 NICHD Pediatric Terminology C81254 Grasp Reflex Grasp Reflex An involuntary, primal response in the neonate to grasp the fingers when their palm is touched. This reflex is present until six months of age. An involuntary response in the neonate to grasp the fingers when the palm is touched, that disappears by 4-6 months of age. C81181 Infant Reflex C90259 NICHD Pediatric Terminology C87168 Group B Streptococcal Infection Group B Streptococcal Infection Group B Streptococcus, also known as Streptococcus agalactiae, colonizes the vaginal and gastrointestinal tracts of up to 45% of healthy women and may infect neonates in utero or during delivery, causing neonatal sepsis in 1-2% of colonized neonates. GBS infection may also occur in nonpregnant (particularly elderly) adults with underlying medical conditions, presenting as urinary tract infection, pneumonia, or soft-tissue infection. Infection of an infant from birth to three months caused by Group B Streptococcus (Streptococcus agalactiae) from a colonized mother. Invasive infections may include sepsis, meningitis, and pneumonia. C2890 Bacterial Disease C90259 NICHD Pediatric Terminology C80444 H1N1 Influenza H1N1 Influenza Swine flu An acute viral respiratory infection caused by a strain of influenza virus which is endemic in swine (pigs). Rarely reported in humans prior to 2009, the disease is caused by a mutated strain of swine influenza A (H1N1) virus. It is highly contagious and spreads mainly through coughing and sneezing. Signs and symptoms include fever, chills, coughing, sore throat headache, muscle ache, and generalized weakness. Antiviral medications are most effective in the first two days of the illness. C53482 Influenza C90259 NICHD Pediatric Terminology C1126 Haemophilus Influenzae B Vaccine Haemophilus Influenzae B Vaccine Hib Vaccine|PRP vaccine A vaccine against serotype b of the Gram-negative bacterium H. influenzae (Hib). Hib vaccines contain polysaccharide-protein conjugate antigens that produce greater host immune responses than first-generation purified polysaccharide vaccine. These vaccines may differ with regard to use of protein carriers, polysaccharides, diluents, and preservatives. C1455 Conjugate Vaccine C90259 NICHD Pediatric Terminology C32712 Hand Hand The distal portion of the upper extremity. It consists of the carpus, metacarpus, and digits. C32221 Body Part C90259 NICHD Pediatric Terminology C12419 Head Head The anterior and superior part of a human bearing the mouth, the brain and sensory organs. C32221 Body Part C90259 NICHD Pediatric Terminology C81255 Head Circumference Head Circumference A circumferential measurement of the head at the widest point, which is traditionally above the eyebrows. The widest measurement of the head, when it is measured at its occipitofrontal circumference. C25334 Length C90259 NICHD Pediatric Terminology C25178 Health Health Refers to a person's state of physical, mental and social well-being; usually it refers specifically to the state of being in good health, a state of complete physical, mental and social well-being, and does not consist only of the absence of disease or infirmity. In any organism health constitutes a form of homeostasis with inputs and outputs of energy and mass in approximate equilibrium allowing for growth and continued survival. In humans, a subjective feeling of well-being coming from somatic and cognitive perceptions is considered an essential component of health. C92722 Qualitative Concept C90259 NICHD Pediatric Terminology C35731 Hearing Loss Hearing Loss A partial or complete loss of hearing in one or both ears. It is classified as conductive, sensory, or central. Impaired ability to hear. C63711 Sensory Disorder C90259 NICHD Pediatric Terminology C84480 Heart Murmur Heart Murmur A periodic humming or blowing sound heard on auscultation of the heart that can indicate the presence of cardiac disease; murmurs are the result of vibrations caused by the turbulent flow of blood in the heart or great vessels. Murmurs are characterized according to the area of generation (mitral, aortic, tricuspid, or pulmonary) and according to the period of the cycle (systolic or diastolic). C35552 Cardiovascular System Finding C90259 NICHD Pediatric Terminology C49677 Heart Rate Heart Rate The number of heartbeats per unit of time, usually expressed as beats per minute. C35552 Cardiovascular System Finding C90259 NICHD Pediatric Terminology C81309 Heart Rate Score Heart Rate Score A component of the Apgar score, it is the numerical value assigned to an assessment of the circulatory status of a neonate. 0 = no pulse; 1 = rate less than 100 beats per minute; 2 = rate greater than 100 beats per minute. A component of the Apgar score, it is the numerical value assigned to an assessment of the circulatory status of a neonate. 0 = no pulse; 1 = rate less than 100 beats per minute; 2 = rate greater than 100 beats per minute. C35552 Cardiovascular System Finding C90259 NICHD Pediatric Terminology C87081 Heart Rhythm Heart Rhythm The recurrent, measured movements (rhythm) of a beating heart. C35552 Cardiovascular System Finding C90259 NICHD Pediatric Terminology C89513 Heel to Ear Measurement Heel to Ear Measurement Useful in assessing neonatal neuromuscular development, this is obtained when the infant is placed in a supine position and the infant's feet are grasped pulled toward the ipsilateral ears. The examiner measures the angle made by the arc from the table to the infant's heels; increased angle for age suggests hypotonia, and decreased angle for age suggests hypertonia. C84749 Newborn Examination C90259 NICHD Pediatric Terminology C84750 HELLP Syndrome HELLP Syndrome Severe preeclampsia associated with any of the following findings: thrombocytopenia (platelets less than 100,000 per microliter), impaired liver function (twice normal elevation of hepatic transaminases; severe, persistent right upper quadrant or epigastric pain), progressive renal insufficiency (serum creatinine greater than 1.1 mg/dL or doubling of baseline in the absence of other renal disease), pulmonary edema, or new-onset cerebral or visual disturbances. Severe preeclampsia associated with any of the following findings: thrombocytopenia (platelets less than 100,000 per microliter), impaired liver function (twice normal elevation of hepatic transaminases; severe, persistent right upper quadrant or epigastric pain), progressive renal insufficiency (serum creatinine greater than 1.1 mg/dL or doubling of baseline in the absence of other renal disease), pulmonary edema, or new-onset cerebral or visual disturbances. C85021 Preeclampsia C90259 NICHD Pediatric Terminology C3085 Hemangioma Hemangioma A benign vascular neoplasm characterized by the formation of capillary-sized or cavernous vascular channels. A benign, vascular neoplasm characterized by the formation of capillary-sized vascular channels. C3262 Neoplasm C90259 NICHD Pediatric Terminology C26323 Hematologic and Lymphocytic Disorder Hematologic Disorder Hematological Disorder A neoplastic or non-neoplastic disorder that affects the production and proliferation of the hematopoietic cells including lymphoid cells, the synthesis of hemoglobin, and/or the mechanisms of coagulation. C2991 Disease or Disorder C90259 NICHD Pediatric Terminology C81276 Hemoglobin A to Total Hemoglobin Ratio Measurement Hemoglobin A to Total Hemoglobin Ratio Measurement The determination of the ratio of Hemoglobin A compared to total Hemoglobin present in a sample. The measurement may be expressed as a ratio or percentage. C64848 Hemoglobin Measurement C90259 NICHD Pediatric Terminology C81277 Hemoglobin A2 to Total Hemoglobin Ratio Measurement Hemoglobin A2 to Total Hemoglobin Ratio Measurement The determination of the ratio of Hemoglobin A2 compared to total Hemoglobin present in a sample. The measurement may be expressed as a ratio or percentage. C64848 Hemoglobin Measurement C90259 NICHD Pediatric Terminology C34675 Hemoglobin C Disease Hemoglobin C Disease An autosomal recessive hemoglobinopathy with a mild clinical course. Most patients are asymptomatic. When symptoms appear, they include mild hemolytic anemia and occasionally jaundice. C3092 Hemoglobinopathy C90259 NICHD Pediatric Terminology C81278 Hemoglobin C to Total Hemoglobin Ratio Measurement Hemoglobin C to Total Hemoglobin Ratio Measurement The determination of the ratio of Hemoglobin C compared to total Hemoglobin present in a sample. The measurement may be expressed as a ratio or percentage. C64848 Hemoglobin Measurement C90259 NICHD Pediatric Terminology C64848 Hemoglobin Measurement Hemoglobin Measurement A quantitative measurement of the amount of hemoglobin present in a sample. C49286 Hematology Test C90259 NICHD Pediatric Terminology C81279 Hemoglobin S to Total Hemoglobin Ratio Measurement Hemoglobin S to Total Hemoglobin Ratio Measurement The determination of the ratio of Hemoglobin S compared to total Hemoglobin present in a sample. The measurement may be expressed as a ratio or percentage. C64848 Hemoglobin Measurement C90259 NICHD Pediatric Terminology C101304 Hemolytic Disease of the Newborn Hemolytic Disease of the Newborn A disorder of the fetus or newborn that occurs when fetal cells that are coated with IgG alloantibodies from the mother attack antigens inherited from the father. Severity can range from absence of symptoms to death. A condition of the newborn characterized by the destruction of red blood cells initiated by the transmission of IgG antibodies from mother to child via the placenta. C3092 Hemoglobinopathy C98996 Neonatal Disorder C90259 NICHD Pediatric Terminology C3096 Hepatitis A Infection Hepatitis A Infection Hepatitis A Acute inflammation of the liver caused by the hepatitis A virus. It is highly contagious and usually contracted through close contact with an infected individual or their feces, contaminated food or water. C3439 Viral Infection C90259 NICHD Pediatric Terminology C29090 Hepatitis A Vaccine Hepatitis A Vaccine An inactivated virus vaccine that provides active immunization against hepatitis A virus (HAV). Immunization with hepatitis A vaccine induces the formation of anti-HAV antibodies which provide protection against hepatitis A infection. C29694 Inactivated Vaccine C90259 NICHD Pediatric Terminology C3097 Hepatitis B Infection Hepatitis B Infection Hepatitis B A viral infection caused by the hepatitis B virus. C3439 Viral Infection C90259 NICHD Pediatric Terminology C29091 Hepatitis B Vaccine Hepatitis B Vaccine Recombinant Hepatitis B Vaccine A non-infectious mixture containing recombinant hepatitis B surface antigen (HBsAg) in a liquid vehicle. Immunization with the hepatitis B vaccine induces the formation of specific anti-hepatitis B antibodies and an active immunity against hepatitis B infection. C1572 Recombinant Viral Vaccine C90259 NICHD Pediatric Terminology C34685 Hernia Hernia The protrusion of part of an organ or fibroadipose tissue through an abnormal opening. C107377 Musculoskeletal System Disorder C90259 NICHD Pediatric Terminology C87083 Heterotaxy Heterotaxy Heterotaxia The abnormal arrangement or position of thoracic and/or abdominal organs in relation to each other, often occurring in a right/left transposition. C97151 Congenital Systemic Disorder C90259 NICHD Pediatric Terminology C87169 High Pitched Cry High Pitched Cry An abnormally shrill or screeching vocalization made by infants that could possibly indicate the presence of one of an array of medical conditions or congenital syndromes. An abnormally shrill or screeching vocalization made by infants that could possibly indicate the presence of one of an array of medical conditions or congenital syndromes. C100104 Sign or Symptom C90259 NICHD Pediatric Terminology C70933 High Test Reference Range High Test Reference Range Reported upper limit of the test reference range. C38013 Range C90259 NICHD Pediatric Terminology C1951 Human Papilloma Virus Vaccine Human Papilloma Virus Vaccine Recombinant Human Papilloma Virus Vaccine A recombinant vaccine of different types of HPV proteins which are well-conserved within types with a significant inter-type variation. C1572 Recombinant Viral Vaccine C90259 NICHD Pediatric Terminology C14226 Human Papillomavirus Human Papillomavirus Human Papilloma Virus A strain of papillomavirus that can infect the skin and mucous membranes of humans. C14283 Virus C90259 NICHD Pediatric Terminology C14338 Human Papillomavirus-16 Human Papillomavirus-16 A virus comprised of a protein coat (capsid) surrounding a circular, double-stranded DNA organized into coding and non-coding regions, which can induce skin and mucosal epithelial lesions. Human papillomavirus-16 (HPV16) has been directly linked to cervical cancer and is significantly associated with invasiveness. Progression from low- to high-grade neoplasia is often associated with the integration of the HPV16 genome into the host chromosome. C14226 Human Papillomavirus C90259 NICHD Pediatric Terminology C14377 Human Papillomavirus-18 Human Papillomavirus-18 A virus comprised of a protein coat (capsid) surrounding a circular, double-stranded DNA organized into coding and non-coding regions, which can induce skin and mucosal epithelial lesions. Human papillomavirus-18 (HPV18) has been directly linked to cervical cancer and plays a role in the pathogenesis of the disease. The virus integrates its DNA at specific chromosomal locations, such as 8q24 and 12q15. The use of molecular markers for HPV18 infection may allow the identification of patients with early stage cervical cancer and those at high risk for disease recurrence. C14226 Human Papillomavirus C90259 NICHD Pediatric Terminology C87084 Hyperemesis Gravidarum Hyperemesis Gravidarum Severe, intractable vomiting during pregnancy (usually the first trimester) accompanied by dehydration, weight loss, and electrolyte imbalances. Severe, intractable vomiting during early pregnancy accompanied by hypovolemia, weight loss, and electrolyte imbalances. C34941 Pregnancy Complication C90259 NICHD Pediatric Terminology C3117 Hypertension Hypertension Hypertensive Disorder Blood pressure that is abnormally high. Abnormally high blood pressure. C2931 Cardiovascular Disorder C35552 Cardiovascular System Finding C90259 NICHD Pediatric Terminology C50589 Hyperthermia Hyperthermia A condition characterized by an abnormally high body temperature. In a hyperthermic state, the hypothalamic set-point is normal but body temperature increases and overrides the ability to lose heat, resulting from exogenous heat exposure or endogenous heat production. Elevation of body temperature above normal due to the production or absorption of more heat than the body is able to dissipate. C100104 Sign or Symptom C90259 NICHD Pediatric Terminology C87085 Hypertonia Hypertonia A condition of increased muscle tone manifested by increased resistance of the muscle to passive stretching. A condition characterized by increased resistance to passive stretching and abnormal positioning due to spasticity.|Abnormally high muscle tone. C100104 Sign or Symptom C90259 NICHD Pediatric Terminology C87070 Hypotonia Hypotonia A condition of decreased tone of the skeletal muscles and diminished resistance to passive stretching. A condition characterized by decreased resistance to passive stretching and diminished muscle activity.|Abnormally low muscle tone. C100104 Sign or Symptom C90259 NICHD Pediatric Terminology C3890 Hypoxia Hypoxia A decrease in the amount of oxygen in the body. Symptoms range from mild (impaired judgment, memory loss, impaired motor coordination) to severe (seizures and coma). A condition in which there is low oxygen in the tissues. C45233 Respiratory System Finding C90259 NICHD Pediatric Terminology C25737 Identification Identification The procedure of having an identity established. C92722 Qualitative Concept C90259 NICHD Pediatric Terminology C81289 Image Identifier Image Identifier A sequence of letters, numbers, or other characters that specifically identifies a particular image. C18772 Personal Medical History C90259 NICHD Pediatric Terminology C81256 Imaging Information Imaging Information A collection of data pertinent to a radiographic study. C18772 Personal Medical History C90259 NICHD Pediatric Terminology C3507 Immune System Disorder Immune System Disorder A disorder resulting from an abnormality in the immune system. C2991 Disease or Disorder C90259 NICHD Pediatric Terminology C15258 Immunization Immunization Inoculating an individual with either killed or live agents to prevent contraction of a disease. C25218 Intervention or Procedure C90259 NICHD Pediatric Terminology C91715 Inactivated Poliovirus Vaccine Inactivated Poliovirus Vaccine A vaccine consisting of inactivated poliovirus (IPV) types 1,2 and 3, with active immunizing activity against poliomyelitis. Upon intramuscular vaccination, inactivated poliovirus vaccine (IPV) activates the immune system to develop antibodies against polioviruses. C29694 Inactivated Vaccine C90259 NICHD Pediatric Terminology C29694 Inactivated Vaccine Inactivated Vaccine A preparation of killed microorganisms that is intended to prevent or treat an infectious disease by inducing active immunity to the causative microorganism. C923 Vaccine C90259 NICHD Pediatric Terminology C48500 Inch Inch A traditional unit of length equal to 1/12 of a foot or 2.54 centimeters. C25709 Unit of Measure C90259 NICHD Pediatric Terminology C25180 Indicator Indicator An event, entity or condition that typically characterizes a prescribed environment or situation and determines or aids in determining whether certain stated circumstances exist or criteria are satisfied. C92722 Qualitative Concept C90259 NICHD Pediatric Terminology C89889 Infancy Infancy Infant Stage The period of life between 28 days and 13 months of age. A human life stage that begins at birth and continues until twelve complete months of age. C89345 Childhood C90259 NICHD Pediatric Terminology C27956 Infant Infant A young child between one month and two years of age. C16423 Child C90259 NICHD Pediatric Terminology C81249 Infant Formula Infant Formula A nutritional substitute for breast milk, usually with a foundation of cow or soy milk. C1909 Pharmacologic Substance C90259 NICHD Pediatric Terminology C81181 Infant Reflex Infant Reflex Primitive reflex actions that newborns display in response to specific stimuli. These reflexes are involuntary and most disappear as the infant matures. Involuntary primitive reflex actions occurring in newborn infants in response to specific stimuli that disappear as the infant matures. C118807 C78342 Reflex C90259 NICHD Pediatric Terminology C26726 Infectious Disorder Infectious Disease A disorder resulting from the presence and activity of a microbial, viral, or parasitic agent. It can be transmitted by direct or indirect contact. C2991 Disease or Disorder C90259 NICHD Pediatric Terminology C53482 Influenza Influenza Flu An acute viral infection of the respiratory tract, occurring in isolated cases, in epidemics, or in pandemics; it is caused by serologically different strains of viruses (influenzaviruses) designated A, B, and C, has a 3-day incubation period, and usually lasts for 3 to 10 days. It is marked by inflammation of the nasal mucosa, pharynx, and conjunctiva; headache; myalgia; often fever, chills, and prostration; and occasionally involvement of the myocardium or central nervous system. C3439 Viral Infection C90259 NICHD Pediatric Terminology C96408 Influenza Vaccination Influenza Vaccination The administration of live or attenuated influenza virus for the prophylaxis of influenza. C15258 Immunization C90259 NICHD Pediatric Terminology C97250 Intellectual Disability Intellectual Disability Intellectual Disabilities A broad category of disorders characterized by an impairment to the intelligence an individual possesses. These impairments can result from trauma, birth, or disease and are not restricted to any particular age group. C96413 Brain Disorder C90259 NICHD Pediatric Terminology C87087 Intercostal Retractions Intercostal Retractions The marked inward movement of the muscles between the ribs during inhalation; they indicate that there is reduced pressure in the chest cavity and can be a sign of breathing difficulties. C100104 Sign or Symptom C90259 NICHD Pediatric Terminology C32856 Internal Nare Internal Nare The inner portion of the nostrils of the nose. C32221 Body Part C90259 NICHD Pediatric Terminology C25218 Intervention or Procedure Intervention or Procedure An activity that produces an effect, or that is intended to alter the course of a disease in a patient or population. This is a general term that encompasses the medical, social, behavioral, and environmental acts that can have preventive, therapeutic, or palliative effects. C89505 Prenatal and Pediatric Terminology C90259 NICHD Pediatric Terminology C28161 Intramuscular Route of Administration Intramuscular Route of Administration Intramuscular injection is a route of drug administration via injection into muscle tissue. Aqueous or oleaginous solutions and emulsions or suspensions may be administered. Absorption rates, delay in availability of the drug to the systemic circulation, and duration of effect are perfusion-limited, depend on molecular size of the agent, volume, and osmolarity of the drug solution, fat content of the injection site, and patient physical activity. C38291 Parenteral Route of Administration C90259 NICHD Pediatric Terminology C38276 Intravenous Route of Administration Intravenous Route of Administration Administration of a drug within or into a vein or veins. Introduction of the drug directly into venous circulation results in 100% bioavailability due to an absence of the absorption phase, provides a precise and continuous mode of drug therapy, especially for drugs with a narrow therapeutic index. C38291 Parenteral Route of Administration C90259 NICHD Pediatric Terminology C50896 Intraventricular Brain Hemorrhage Intraventricular Hemorrhage Bleeding into the brain's ventricles. C50438 Intracranial Hemorrhage C90259 NICHD Pediatric Terminology C87089 Irregular Respiration Irregular Respiration Irregular Breathing A change from the normal breathing pattern in an infant, child, or adult, in terms of the amplitude and frequency of inhalations and exhalations. C100104 Sign or Symptom C90259 NICHD Pediatric Terminology C32884 Ischium Ischium The most posterior and ventral bone making up the pelvis. C32221 Body Part C90259 NICHD Pediatric Terminology C25215 Karyotype Karyotype The assessment of the chromosomal morphology and number in somatic cells of an individual. The assessment of the chromosomal morphology and number in somatic cells of an individual. C15709 Genetic Testing C90259 NICHD Pediatric Terminology C32898 Knee Joint Knee Joint A joint connecting the lower part of the femur with the upper part of the tibia. The lower part of the femur and the upper part of the tibia are attached to each other by ligaments. Other structures of the knee joint include the upper part of the fibula, located below and parallel to the tibia, and the patella which moves as the knee bends. C32221 Body Part C90259 NICHD Pediatric Terminology C87090 Labial Fusion Labial Fusion Usually found in girls between 6 months and 6 years of age, this condition occurs wherein the labia grow together instead of as 2 separate folds, thereby blocking the opening of the vagina. It is caused by conditions such as repeated diaper rash, urine and stool infections, and sexual abuse. The condition often spontaneously corrects or responds to the application of estrogen cream. C103185 Congenital Reproductive System Abnormality C90259 NICHD Pediatric Terminology C25294 Laboratory Procedure Laboratory Procedure Any procedure that involves testing or manipulating a sample of blood, urine, or other body substance in a laboratory setting. C18020 Diagnostic Procedure C90259 NICHD Pediatric Terminology C36292 Laboratory Test Result Laboratory Test Result The outcome of a laboratory test. C3367 Finding C90259 NICHD Pediatric Terminology C97155 Language Disorder Language Disorder A category of disorders characterized by an impairment in the development of an individual's language capabilities, which is in contrast to his/her non-verbal intellect. C92190 Pediatric Psychiatric Disorder C90259 NICHD Pediatric Terminology C34197 Lanugo Lanugo Fine downy hair that covers the body of a human fetus beginning in the fifth month of gestation; it is usually shed by the ninth month of gestation. C32221 Body Part C90259 NICHD Pediatric Terminology C87092 Large for Gestational Age Large for Gestational Age A fetus or infant who is larger than expected for the age or gender, or who has a birth weight greater than the 90th percentile. A newborn infant who has a birth weight greater than the 90th percentile based on gestational age.|An estimated fetal or neonatal weight exceeding 90% of expected weight for gestational age. C92711 Fetal Finding C90259 NICHD Pediatric Terminology C81310 Lasso-O Measuring Tape Lasso-O Measuring Tape A measuring tape frequently used to measure head circumference in newborns. A measuring tape frequently used to measure head circumference in newborns. It can measure any circumference to the nearest millimeter and is manufactured from paper-thin, non-stretch, non-shrink plastic. C62103 C90259 NICHD Pediatric Terminology C81257 Last Menstrual Period Last Menstrual Period The first day of the female's last menstrual cycle. C92720 C90259 NICHD Pediatric Terminology C81258 Last Screening Last Screening The most recent screening. C25164 Date C90259 NICHD Pediatric Terminology C89344 Late Adolescence Late Adolescence A transitional time in an individual's life between adolescence and early adulthood. This phase includes the final stages of pubertal growth and development as well as the attainment of significant psycho-social milestones. A human life stage that begins at nineteen years of age and continues until twenty-one complete years of age. This phase includes the final stages of pubertal growth and development as well as the attainment of significant psycho-social milestones. C39298 Adolescence C90259 NICHD Pediatric Terminology C89334 Learning Disorder Learning Disorder A group of disorders that affect a person's ability to learn or process specific types of information which is in contrast to his/her apparent level of intellect. C92190 Pediatric Psychiatric Disorder C90259 NICHD Pediatric Terminology C81259 Left Ear Left Ear The organ of hearing located on the left side of the head. C12394 Ear C90259 NICHD Pediatric Terminology C32974 Leg Leg One of the two lower extremities in humans used for locomotion and support. C32221 Body Part C90259 NICHD Pediatric Terminology C25334 Length Length The linear extent in space from one end of something to the other end, or the extent of something from beginning to end. C25447 Characteristic C90259 NICHD Pediatric Terminology C89335 Life Stage Life Stage A designation assigned to a particular period during a life cycle, generally defined by chronological parameters. C21514 Temporal Qualifier C90259 NICHD Pediatric Terminology C12220 Lip Lip Fleshy fold which surrounds the opening of the mouth. C32221 Body Part C90259 NICHD Pediatric Terminology C96402 Live Attenuated Influenza Vaccine Live Attenuated Influenza Vaccine Nasal Spray Flu Vaccine A vaccine that contains live attenuated influenza virus (LAIV) particles. This vaccine is administered intranasally for influenza prophylaxis. Not all populations are good candidates for LAIV; the very young, elderly, asthmatics and those with health impaired may be better treated with the trivalent inactivated vaccine that is administered intramuscularly. C1920 Attenuated Live Virus Vaccine C90259 NICHD Pediatric Terminology C81260 Local Anesthesia Procedure Local Anesthesia Procedure The temporary suppression of sensation at a specific region of the body by pharmacological intervention. This type of anesthesia does not induce unconsciousness in the patient. C15181 Anesthesia Procedure C90259 NICHD Pediatric Terminology C87128 Loose Stool Loose Stool Watery Stool Frequent, loose, and watery stools are noted in most infants, even if they are fed formula, until they are six to eight weeks old; after that, the stools become firmer and less frequent. C100104 Sign or Symptom C90259 NICHD Pediatric Terminology C34724 Low Birth Weight Low Birth Weight A birth weight that is less than 2500 grams. Birth weight less than 2500 grams. C76325 Birth Weight C90259 NICHD Pediatric Terminology C70934 Low Test Reference Range Low Test Reference Range Reported low limit of the test reference range. C38013 Range C90259 NICHD Pediatric Terminology C97175 Low Vision Low Vision Reduced ability to perceive visual stimuli. C35126 Vision Disorder C90259 NICHD Pediatric Terminology C50644 Lung Overinflation Lung Overinflation Abnormal permanent enlargement of the lung air spaces distal to terminal bronchiole not resulted from wall destruction, e.g. due to loss of opposite lung. C100104 Sign or Symptom C90259 NICHD Pediatric Terminology C25381 Maiden Name Maiden Name A woman's surname before marriage. C90492 Personal Information C90259 NICHD Pediatric Terminology C34797 Malaria Malaria A protozoan infection caused by the genus Plasmodium. There are four species of Plasmodium that can infect humans: Plasmodium falciparum, vivax, ovale, and malariae. It is transmitted to humans by infected mosquitoes. Signs and symptoms include paroxysmal high fever, sweating, chills, and anemia. Plasmodium parasite infection, characterized by fever, flu-like symptoms, anemia, and jaundice, that may be transmitted through infected mosquito bites, blood transfusion, organ transplant, contaminated needles or syringes, or before or during birth. C27864 Parasitic Infection C90259 NICHD Pediatric Terminology C20197 Male Male A person who belongs to the sex that normally produces sperm. The term is used to indicate biological sex distinctions, cultural gender role distinctions, or both. C28421 Sex C90259 NICHD Pediatric Terminology C87068 Male Circumcision Male Circumcision Circumcision Surgical removal of the penile foreskin. Surgical removal of the penile foreskin. C15329 C90259 NICHD Pediatric Terminology C27019 Male Reproductive System Disorder Male Reproductive System Disorder A non-neoplastic or neoplastic disorder that affects the male genital system. Representative examples of non-neoplastic disorders include infection, testicular torsion, and undescended testis. Representative examples of neoplastic disorders include germ cell tumors, carcinoma, lymphoma, and sarcoma. C4875 Reproductive System Disorder C90259 NICHD Pediatric Terminology C90337 Maternal Life Stage Maternal Life Stage The period of time during a female's reproductive years that she functions as a mother. C89335 Life Stage C90259 NICHD Pediatric Terminology C90338 Maternal Postnatal Stage Maternal Postnatal Stage Postnatal Stage The stage in the life of a mother after she has given birth. C90337 Maternal Life Stage C90259 NICHD Pediatric Terminology C90340 Maternal Preconception Stage Maternal Preconception Stage Preconception Stage The stage in the life of a female during which she is attempting to get pregnant. C90337 Maternal Life Stage C90259 NICHD Pediatric Terminology C90339 Maternal Prenatal Stage Maternal Prenatal Stage Prenatal Stage The stage in the life of a mother during which she is pregnant. C90337 Maternal Life Stage C90259 NICHD Pediatric Terminology C17770 Maturation Maturation The act, or process, of natural progression in physical and psychological maturation from a previous, lower, or embryonic stage to a later, more complex, or adult stage. C19988 Organismal Process C90259 NICHD Pediatric Terminology C96406 Measles Measles Rubeola A highly contagious viral infection caused by the measles virus. Symptoms appear 8-12 days after exposure and include a rash, cough, fever and muscle pains that can last 4-7 days. Measles vaccines are available to provide prophylaxis, usually combined with mumps and rubella vaccines (MMR). C96411 Pediatric Viral Infection C90259 NICHD Pediatric Terminology C96403 Measles/Mumps/Rubella Vaccine Measles/Mumps/Rubella Vaccine Measles Mumps Rubella Vaccine A trivalent vaccine containing live attenuated viruses that can cause measles, mumps and rubella. It is an injection administered subcutaneously in two separate doses. C1920 Attenuated Live Virus Vaccine C90259 NICHD Pediatric Terminology C87093 Meconium Aspiration Syndrome Meconium Aspiration Syndrome A serious condition in which a newborn breathes a mixture of meconium (the first intestinal discharge) and amniotic fluid into the lungs around the time of delivery. Meconium aspiration syndrome occurs in 5-10 percent of births and typically occurs when the infant is stressed, as when the infant is past its due date. Aspiration of meconium around the time of delivery resulting in severe respiratory distress. C97173 Congenital Respiratory System Disorder C90259 NICHD Pediatric Terminology C81262 Medical Record Number Medical Record Number An identifying number within an institution that is used to reference a subject's medical information. C18772 Personal Medical History C90259 NICHD Pediatric Terminology C90603 Medication Administered at Birth Medication Administered at Birth Medication Given at Birth Pharmacologic agents administered to a neonate at birth. C49236 Therapeutic Procedure C90259 NICHD Pediatric Terminology C26828 Meningitis Meningitis A disorder characterized by acute inflammation of the meninges of the brain and/or spinal cord. Inflammation of the membranes surrounding the brain and spinal cord. C27582 Central Nervous System Infectious Disease C90259 NICHD Pediatric Terminology C96391 Meningococcal Conjugate Vaccine MCV4 Meningococcal Conjugate Vaccine MCV4 Meningococcal Conjugate Vaccine MCV-4 A conjugate vaccine of meningococcal polysaccharide used for active immunization against invasive meningococcal disease caused by Neisseria meningiditis serogroups A, C, Y, and W-135. C1455 Conjugate Vaccine C90259 NICHD Pediatric Terminology C96519 Meningococcal Polysaccharide Vaccine MPSV4 Meningococcal Polysaccharide Vaccine MPSV4 Meningococcal Polysaccharide Vaccine MPSV-4 A polysaccharide vaccine used to prevent contraction of meningococcal meningitis. C97125 Polysaccharide Vaccine C90259 NICHD Pediatric Terminology C81263 Mental Development Index Mental Development Index A sequential arrangement of information pertaining to the evolution of an individual's cognitive development. C81314 Newborn Behavioral Examination C90259 NICHD Pediatric Terminology C84392 Mental Retardation Mental Retardation A developmental disorder characterized by less than average intelligence and significant limitations in adaptive behavior with onset before the age of 18. A condition of arrested or incomplete development of the mind, which is especially characterized by impairment of skills manifested during the developmental period, which contribute to the overall level of intelligence, i.e. cognitive, language, motor, and social abilities. C92190 Pediatric Psychiatric Disorder C90259 NICHD Pediatric Terminology C81264 Mental Scale Mental Scale A range of values that characterizes an individual's mental development. C81314 Newborn Behavioral Examination C90259 NICHD Pediatric Terminology C87094 Micrognathism Micrognathism A congenital abnormality of the jaws (particularly the mandible) in which they are unusually small. This condition is not always pathological and may correct itself as the patient matures; however, it may also present as a birth defect in multiple syndromes. C89337 Congenital Musculoskeletal Defect C90259 NICHD Pediatric Terminology C67405 Microinternational Unit per Milliliter Microinternational Unit per Milliliter Unit of arbitrary substance concentration (biologic activity concentration) defined as the concentration of one millionth of international unit per one milliliter of system volume. C25709 Unit of Measure C90259 NICHD Pediatric Terminology C89347 Middle Childhood Middle Childhood The time period in a child's life that is generally defined as between 5 and 10 years of life. A human life stage that begins at six years of age and continues until eleven complete years of age. C89345 Childhood C90259 NICHD Pediatric Terminology C67015 Milligram per Deciliter Milligram per Deciliter A unit of mass concentration defined as the concentration of one milligram of a substance in unit volume of the mixture equal to one cubic deciliter or 100 cubic centimeters. It is also a unit of mass density (volumic mass) defined as the density of substance which mass equal to one milligram occupies the volume one cubic deciliter or 100 cubic centimeters. C25709 Unit of Measure C90259 NICHD Pediatric Terminology C64387 Millimole per Liter Millimole per Liter A unit of concentration (molarity unit) equal to one thousandth of a mole (10E-3 mole) of solute per one liter of solution. C25709 Unit of Measure C90259 NICHD Pediatric Terminology C97177 Mixed Cerebral Palsy Mixed Cerebral Palsy A subtype of cerebral palsy characterized by both the tight muscle tone of spastic cerebral palsy and the writhing, involuntary muscle movements of athetoid cerebral palsy. A type of cerebral palsy characterized by both increased muscle tone and involuntary, purposeless writhing movements that affect the hands, feet, arms, and legs. C34460 Cerebral Palsy C90259 NICHD Pediatric Terminology C26974 Mixed Hearing Loss Mixed Hearing Loss Hearing loss characterized by a combination of conductive and sensorineural hearing loss. It is caused by problems in both the inner ear and middle or outer ear. A combination of conductive and sensorineural hearing loss. C35731 Hearing Loss C90259 NICHD Pediatric Terminology C41147 Modality Modality A specific manner, characteristic, pattern of application or the employment of, any therapeutic agent or method of treatment, especially involving the physical treatment of a condition. C25447 Characteristic C90259 NICHD Pediatric Terminology C81268 Molar Ratio Molar Ratio The relative number of moles of one substance to another in a chemical reaction. C25709 Unit of Measure C90259 NICHD Pediatric Terminology C81311 Moro Reflex Moro Reflex An involuntary, primal response in the neonate to loud noise or the feeling of falling. The response is characterized by the infant's arms symmetrically spreading out to the side and then back to the midline, and involuntarily flexing the fingers and toes. An involuntary response in the neonate to the feeling of falling or a loud noise characterized by the infant's arms symmetrically spreading out to the side and then back to the midline, and flexion of the fingers and toes, that disappears by 4-6 months of age. C81181 Infant Reflex C90259 NICHD Pediatric Terminology C81269 Motor Development Motor Development The evolution of physical movement over an individual's lifespan. C17770 Maturation C90259 NICHD Pediatric Terminology C5039 Motor Manifestations Motor Manifestations The presence of an alteration in the ability to move one's body or any body parts in accordance with one's intent. C100104 Sign or Symptom C90259 NICHD Pediatric Terminology C87095 Mottling Mottling Irregularly shaped, patchy discolorations in the skin. A patchy appearance of the skin caused by underlying blood vessel changes.|Irregularly shaped and discolored patches on the skin. C36281 Integumentary System Finding C100104 Sign or Symptom C90259 NICHD Pediatric Terminology C87096 Movement of Lip Corners Movement of Lip Corners During examination of the newborn infant, the examiner looks for symmetric movement of the lip corners. Movement of the lip corners is governed by the zygomatic major muscle. C100104 Sign or Symptom C90259 NICHD Pediatric Terminology C81271 Multiple Birth Multiple Birth Multiple fetuses birthed live or dead in a single pregnancy regardless of gestational age, and regardless of whether the fetuses were birthed on different dates. Multiple fetuses birthed live or dead in a single pregnancy regardless of gestational age, and regardless of whether the fetuses were birthed on different dates. C25742 Pregnancy C90491 C90259 NICHD Pediatric Terminology C29888 Mumps Mumps A contagious viral infection caused by the mumps virus. Symptoms include swollen and tender parotid glands, fever, muscle aches and fatigue. Due to vaccination programs, mumps has become a rare disease. C96411 Pediatric Viral Infection C90259 NICHD Pediatric Terminology C81312 Muscle Tone Score Muscle Tone Score A component of the Apgar score, it is the numerical value assigned to an assessment of the residual muscle tension of a neonate. 0 = flaccid; 1 = flexion of extremities; 2 = active motion. A component of the Apgar score, it is the numerical value assigned to an assessment of the residual muscle tension of a neonate. 0 = flaccid; 1 = flexion of extremities; 2 = active motion. C118807 C90259 NICHD Pediatric Terminology C107377 Musculoskeletal System Disorder Musculoskeletal System Disorder A category of diseases that involve muscles and bones. C2991 Disease or Disorder C90259 NICHD Pediatric Terminology C34832 Myoclonic Jerk Myoclonic Jerk A sudden, involuntary contraction of a muscle or group of muscles; these movements may develop as a symptom of a number of neurological diseases including epilepsy, Parkinson's disease, Alzheimer's disease, or Creutzfeldt-Jacob disease. C100104 Sign or Symptom C90259 NICHD Pediatric Terminology C67326 Nanogram per Deciliter Nanogram per Deciliter A unit of mass concentration defined as the concentration of one nanogram of a substance per unit volume of the mixture equal to one deciliter. The concept also refers to the unit of mass density (volumic mass) defined as the density of substance which mass equal to one nanogram occupies the volume of one deciliter. C25709 Unit of Measure C90259 NICHD Pediatric Terminology C78500 Nasal Congestion Nasal Congestion The blockage of the nasal passage due to mucosal edema. It is usually the result of a viral infection or an allergic reaction. The blockage of the nasal passage due to mucosal edema or secretions. C100104 Sign or Symptom C90259 NICHD Pediatric Terminology C87099 Nasal Flaring Nasal Flaring Enlargement of the nostrils during breathing; although there are many possible causes, it can be a sign of respiratory distress in young infants. C100104 Sign or Symptom C90259 NICHD Pediatric Terminology C38284 Nasal Route of Administration Nasal Route of Administration Administration of a drug by the way of the nose. This often results in systemic action of the agent due to absorption through the nasal mucosa. The richly supplied vascular nature of the nasal mucosa coupled with its high drug permeation makes the nasal route of administration attractive for many drugs, including proteins and peptides. C38114 Route of Administration C90259 NICHD Pediatric Terminology C13063 Neck Neck The region that connects the head to the rest of the body. C32221 Body Part C90259 NICHD Pediatric Terminology C86605 Neisseria meningitidis Neisseria meningitidis A species of aerobic, Gram-negative, diplococci shaped bacteria assigned to the phylum Proteobacteria. This species is catalase and oxidase positive, non-hemolytic, non-pigmented, does not reduce nitrate or nitrite, does not synthesize polysaccharides, grows on blood, chocolate, or Muller-Hinton agar, and produces acid from glucose and maltose but not fructose, sucrose, mannose, or lactose. N. meningitidis, known commonly as meningococcus, is the causative agent of cerebrospinal meningitis, but is also associated with other human infections, but can be commensal in the oropharynx and nasopharynx of carriers. C14187 Bacteria C90259 NICHD Pediatric Terminology C87101 Neonatal Abstinence Syndrome Neonatal Abstinence Syndrome A constellation of neurobehavioral features observed in a neonate following antenatal exposure to drugs including opioids, benzodiazepines, and selective serotonin reuptake inhibitors. A constellation of neurobehavioral features observed in a neonate following antenatal exposure to drugs including opioids, benzodiazepines, and selective serotonin reuptake inhibitors. C101321 Neonatal Drug Withdrawal C90259 NICHD Pediatric Terminology C89515 Neonatal Abstinence Syndrome Assessment Neonatal Abstinence Syndrome Assessment The measurement of the degree to which a neonate is experiencing symptoms of withdrawal due to maternal substance abuse; the score can be used to determine subsequent treatment of the infant. C84749 Newborn Examination C90259 NICHD Pediatric Terminology C3262 Neoplasm Neoplasm A benign or malignant tissue growth resulting from uncontrolled cell proliferation. Benign neoplastic cells resemble normal cells without exhibiting significant cytologic atypia, while malignant cells exhibit overt signs such as dysplastic features, atypical mitotic figures, necrosis, nuclear pleomorphism, and anaplasia. Representative examples of benign neoplasms include papillomas, cystadenomas, and lipomas; malignant neoplasms include carcinomas, sarcomas, lymphomas, and leukemias. C2991 Disease or Disorder C90259 NICHD Pediatric Terminology C26835 Nervous System Disorder Nervous System Disorder Neurologic Disorder A non-neoplastic or neoplastic disorder that affects the brain, spinal cord, or peripheral nerves. C2991 Disease or Disorder C90259 NICHD Pediatric Terminology C84923 Neural Tube Defect Neural Tube Defect A congenital defect characterized by failure of the neural tube to close completely; this results in the presence of openings in the brain or spinal cord. Examples of neural tube defects include encephalocele and spina bifida. C97172 Congenital Nervous System Disorder C90259 NICHD Pediatric Terminology C89338 Neurodevelopmental Disorder Neurodevelopmental Disorder A childhood disorder that has a neurological basis and manifests as a developmental disability. Conditions characterized by impaired central nervous system function occurring in childhood. C89330 Developmental Disorder C90259 NICHD Pediatric Terminology C81313 Neurologic Examination Neurologic Examination The assessment of the functionality of the brain, spinal column, and nerves. C25214 Evaluation Procedure C90259 NICHD Pediatric Terminology C89339 Neurological Screening Neurological Screening A specific type of neurologic examination for early detection of disease(s) and/or disorder(s). C81313 Neurologic Examination C90259 NICHD Pediatric Terminology C89516 Neuromuscular Maturity Assessment Neuromuscular Maturity Assessment A neuromuscular examination of a newborn's developmental characteristics. A neuromuscular examination of a newborn's developmental characteristics to confirm or assign gestational age. C84749 Newborn Examination C90259 NICHD Pediatric Terminology C16731 Newborn Newborn An infant during the first month after birth. C16423 Child C90259 NICHD Pediatric Terminology C81314 Newborn Behavioral Examination Newborn Behavioral Examination The assessment of behavior in neonates. C84749 Newborn Examination C90259 NICHD Pediatric Terminology C87105 Newborn Blood Pressure Newborn Blood Pressure The systolic and diastolic blood pressure of the newborn upon examination; the normal range of the systolic blood pressure is 60 - 90, while the normal range of the diastolic blood pressure is 20-60. C118807 C90259 NICHD Pediatric Terminology C84749 Newborn Examination Newborn Examination A general assessment of the overall health of a newborn. A general assessment of the overall health of a newborn. C90341 Pediatric Intervention or Procedure C90259 NICHD Pediatric Terminology C87103 Newborn Heart Rate Newborn Heart Rate The number of heartbeats of the newborn per minute; the normal range is 100 - 180 heartbeats per minute. C49677 Heart Rate C90259 NICHD Pediatric Terminology C81270 Newborn Motor Scale Newborn Motor Scale A range of values used to quantify newborn motor development. C118807 C90259 NICHD Pediatric Terminology C87104 Newborn Respiratory Rate Newborn Respiratory Rate The number of inhalations and exhalations of the newborn per minute; the normal range is 30 - 60 breaths per minute. C49678 Respiratory Rate C90259 NICHD Pediatric Terminology C81178 Newborn Screening Newborn Screening A specific type of newborn examination performed to allow for early detection of disease(s) and/or disorder(s). A specific type of newborn examination performed to allow for early detection of disease(s) and/or disorder(s). C84749 Newborn Examination C90259 NICHD Pediatric Terminology C49487 No No The non-affirmative response to a question. C25180 Indicator C90259 NICHD Pediatric Terminology C78727 Normal Reference Range Normal Reference Range Reported values within the typical or expected range. C38013 Range C90259 NICHD Pediatric Terminology C94835 Normal Spontaneous Vaginal Delivery Normal Spontaneous Vaginal Delivery Normal Delivery Birth of the fetus through the vagina without the application of vacuum or forceps or any other instrument. (adapted from reVITALize) Birth of the fetus through the vagina without the application of vacuum or forceps or any other instrument. [adapted from reVITALize] C81303 Vaginal Delivery C90259 NICHD Pediatric Terminology C12756 Nose Nose A structure of special sense serving as an organ of the sense of smell and as an entrance to the respiratory tract. C32221 Body Part C90259 NICHD Pediatric Terminology C28294 Nutrition Nutrition That which is consumed to fuel necessary life processes of an organism. C45306 Substance C90259 NICHD Pediatric Terminology C26836 Nutritional Disorder Nutritional Disorder Any condition related to a disturbance between proper intake and utilization of nourishment. C9229 Systemic Disorder C90259 NICHD Pediatric Terminology C25598 Observation Observation Watching something and taking note of what happens. C18020 Diagnostic Procedure C90259 NICHD Pediatric Terminology C88411 Obsessive Compulsive Disorder Obsessive Compulsive Disorder Obsessive-Compulsive Disorder A disorder characterized by the presence of persistent and recurrent irrational thoughts (obsessions), resulting in marked anxiety and repetitive excessive behaviors (compulsions) as a way to try to decrease that anxiety. C2878 Anxiety Disorder C90259 NICHD Pediatric Terminology C81227 One Minute After Birth One Minute After Birth The actual time that is one minute after the birth of a fetus. This period is most commonly referenced during the administration of the Apgar test. C25207 Time C90259 NICHD Pediatric Terminology C12421 Oral Cavity Oral Cavity The cavity located at the upper end of the alimentary canal, behind the teeth and gums that is bounded on the outside by the lips, above by the hard and soft palates and below by the tongue. C32221 Body Part C90259 NICHD Pediatric Terminology C96401 Oral Polio Vaccine Oral Polio Vaccine A vaccine that contains live attenuated polio virus. It is administered orally as polio prophylaxis in many areas of the world, but not in the U.S. since 2000. C1920 Attenuated Live Virus Vaccine C90259 NICHD Pediatric Terminology C38288 Oral Route of Administration Oral Route of Administration The introduction of a substance to the mouth or into the gastrointestinal tract by the way of the mouth, usually for systemic action. It is the most common, convenient, and usually the safest and least expensive route of drug administration, but it uses the most complicated pathway to the tissues and bioavailability varies. The disadvantages of method are hepatic first pass metabolism and enzymatic degradation of the drug within the gastrointestinal tract. This prohibits oral administration of certain classes of drugs especially peptides and proteins. C38114 Route of Administration C90259 NICHD Pediatric Terminology C14250 Organism Organism A living entity. C89505 Prenatal and Pediatric Terminology C90259 NICHD Pediatric Terminology C19988 Organismal Process Organismal Process A biologic function, activity, or process involving either specialized organ functions, individual organs, organ systems, body parts, or whole organisms. C89505 Prenatal and Pediatric Terminology C90259 NICHD Pediatric Terminology C89517 Ortolani Maneuver Ortolani Maneuver When testing for congenital dislocation of the hip, this is the result obtained when the examiner gently abducts the hip while pushing upward on the greater trochanter. If the hip is dislocated, it will relocate with an audible clunk, which is a positive result for this test. C84749 Newborn Examination C90259 NICHD Pediatric Terminology C17649 Other Other Different than the one(s) previously specified or mentioned. C25180 Indicator C90259 NICHD Pediatric Terminology C48519 Ounce Ounce The traditional unit of mass. The avoirdupois ounce is equal to 1/16 pound, or 28.3495 grams, or 0.911 457 troy ounce. C25709 Unit of Measure C90259 NICHD Pediatric Terminology C3303 Pain Pain The sensation of discomfort, distress, or agony, resulting from the stimulation of specialized nerve endings. An unpleasant sensation associated with real or perceived physical or mental trauma. C100104 Sign or Symptom C90259 NICHD Pediatric Terminology C50685 Pallor Pallor An unusual or extreme paleness, state of decreased skin or mucosal coloration. A condition characterized by an abnormal loss of color to the skin or mucous membranes due to reduced delivery of saturated hemoglobin.|An unusual or extreme paleness; state of decreased skin or mucosal color. C100104 Sign or Symptom C90259 NICHD Pediatric Terminology C89514 Palmar Crease Examination Palmar Crease Examination Inspection of palm crease When examining the infant's palm for abnormalities, the examiner may note a single transverse palmar crease, which is found in 5% of newborns and is frequently inherited as a familial trait. However, single palmar creases can be associated with Down's syndrome and other genetic disorders, or with fetal alcohol syndrome. C84749 Newborn Examination C90259 NICHD Pediatric Terminology C97194 Panic Disorder with Agoraphobia Panic Disorder with Agoraphobia A disorder in which an individual experiences recurrent, unexpected panic attacks and persistent concern about having additional panic attacks. Agoraphobia is a component of this disorder. C2878 Anxiety Disorder C90259 NICHD Pediatric Terminology C97193 Panic Disorder without Agoraphobia Panic Disorder without Agoraphobia A disorder in which an individual experiences recurrent, unexpected panic attacks and persistent concern about having additional panic attacks. Agoraphobia is not a component of this disorder. C2878 Anxiety Disorder C90259 NICHD Pediatric Terminology C27864 Parasitic Infection Parasitic Infection Parasitic Disease A successful invasion of a host by an organism that uses the host for food and shelter. C26726 Infectious Disease C90259 NICHD Pediatric Terminology C38291 Parenteral Route of Administration Parenteral Route of Administration Administration of a substance by some means other than through the gastrointestinal tract: usually through injection, infusion, or implantation. Predominantly, the drug action is systemic, but in some cases, it is confined to local area. C38114 Route of Administration C90259 NICHD Pediatric Terminology C81275 Pass Pass One of two possible results of a pass/fail assessment; when the result satisfies a condition. C25180 Indicator C90259 NICHD Pediatric Terminology C89328 Childhood Disorder Pediatric Disorder Pediatric Disease or Disorder A non-neoplastic or neoplastic disorder which occurs during childhood. C2991 Disease or Disorder C90259 NICHD Pediatric Terminology C90341 Pediatric Intervention or Procedure Pediatric Intervention or Procedure A diagnostic or therapeutic course of action usually performed on patients under the age of 18. C25218 Intervention or Procedure C90259 NICHD Pediatric Terminology C92190 Pediatric Psychiatric Disorder Pediatric Psychiatric Disorder Childhood Mental Disorder A category of psychiatric disorders which includes disorders most commonly identified in infancy, childhood, or adolescence. C89328 Pediatric Disorder C90259 NICHD Pediatric Terminology C96411 Childhood Viral Infection Pediatric Viral Infection Childhood Viral Disease A viral infection that occurs during childhood. C89328 Pediatric Disorder C3439 Viral Infection C90259 NICHD Pediatric Terminology C25190 Person Person A human being. C89505 Prenatal and Pediatric Terminology C90259 NICHD Pediatric Terminology C25191 Person Name Person Name A word or group of words indicating the identity of a person usually consisting of a first (personal) name and a last (family) name with an optional middle name. In some cultural traditions the family name comes first. C90492 Personal Information C90259 NICHD Pediatric Terminology C90492 Personal Information Personal Information Data, facts or figures about an individual; the set of relevant items would depend on the use case. C20189 Property or Attribute C90259 NICHD Pediatric Terminology C18772 Personal Medical History Personal Medical History A record of a patient's background regarding health and the occurrence of disease events of the individual. In addition, personal medical history may be a variable in epidemiologic studies. C90492 Personal Information C90259 NICHD Pediatric Terminology C97179 Pervasive Developmental Disorder Pervasive Developmental Disorder A category of developmental disorders characterized by impaired communication and socialization skills. The impairments are incongruent with the individual's developmental level or mental age. These disorders can be associated with general medical or genetic conditions. C96412 Brain Development Abnormality C90259 NICHD Pediatric Terminology C1909 Pharmacologic Substance Pharmacologic Substance Any natural, endogenously-derived, synthetic or semi-synthetic compound with pharmacologic activity. A pharmacologic substance has one or more specific mechanism of action(s) through which it exerts one or more effect(s) on the human or animal body. They can be used to potentially prevent, diagnose, treat or relieve symptoms of a disease. Formulation specific agents and some combination agents are also classified as pharmacologic substances. C45306 Substance C90259 NICHD Pediatric Terminology C81280 Phenylalanine Measurement Phenylalanine Measurement The measurement of the amount of phenylalanine in a biologic specimen. C81183 Amino Acid Measurement C90259 NICHD Pediatric Terminology C81281 Phenylalanine to Tyrosine Ratio Measurement Phenylalanine to Tyrosine Ratio Measurement The determination of the ratio of phenylalanine compared to tyrosine present in a sample. The measurement may be expressed as a ratio or percentage. C81183 Amino Acid Measurement C90259 NICHD Pediatric Terminology C81315 Phenylketonuria Phenylketonuria An autonomic recessive genetic disorder characterized by the body's inability to metabolize and utilize the amino acid phenylalanine, resulting in mental retardation, behavioral and movement problems, seizures, and developmental delays. C97090 Amino Acid Metabolism Disorder C3101 Genetic Disorder C90259 NICHD Pediatric Terminology C20989 Physical Examination Physical Examination A systemic evaluation of the body and its functions using visual inspection, palpation, percussion and auscultation. The purpose is to determine the presence or absence of physical signs of disease or abnormality for an individual's health assessment. C25214 Evaluation Procedure C90259 NICHD Pediatric Terminology C89518 Physical Maturity Assessment Physical Maturity Assessment A physical examination of a newborn's developmental characteristics. A physical examination of a newborn's developmental characteristics to confirm or assign gestational age. C84749 Newborn Examination C90259 NICHD Pediatric Terminology C81316 Physical Symmetry Physical Symmetry A physical attribute of visual balance and proportion between opposing structures. C25447 Characteristic C90259 NICHD Pediatric Terminology C41148 Placement Placement Position or arrangement, as of the teeth; the state of being placed or arranged, as the assignment of a person to a appropriate clinical study. C92722 Qualitative Concept C90259 NICHD Pediatric Terminology C97120 Pneumococcal 10-valent Conjugate Vaccine Pneumococcal 10-valent Conjugate Vaccine An active immunizing vaccine used to prevent infection by the bacterium Streptococcus pneumoniae. It is indicated for disease caused by serotypes 1, 5, 4, 6B, 7, 9V, 14, 18C, 19F, and 23F. C97123 Pneumococcal Conjugate Vaccine C90259 NICHD Pediatric Terminology C97121 Pneumococcal 13-valent Conjugate Vaccine Pneumococcal 13-valent Conjugate Vaccine A pneumococcal conjugate vaccine containing 13 different strains of the bacterium Streptococcus pneumoniae, used in children and studied in immunocompromised patients for the prevention of pneumococcal disease. The pneumococcal 13-valent conjugate vaccine contains capsular antigen polysaccharides derived from the S. pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F that are individually conjugated to a nontoxic diphtheria cross-reactive material (CRM) carrier protein (CRM197). Upon vaccination, pneumococcal 13-valent conjugate vaccine induces active immunization against 13 different serotypes of S. pneumoniae and protects against pneumococcal disease. C97123 Pneumococcal Conjugate Vaccine C90259 NICHD Pediatric Terminology C38141 Pneumococcal 7-Valent Conjugate Vaccine Pneumococcal 7-Valent Conjugate Vaccine An active immunizing agent used to prevent infection by the bacterium Streptococcus pneumoniae. Pneumococcal 7-valent conjugate vaccine consists of a solution of saccharides of the capsular antigens of Streptococcus serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F individually conjugated to diphtheria CRM 197 protein. C97123 Pneumococcal Conjugate Vaccine C90259 NICHD Pediatric Terminology C97123 Pneumococcal Conjugate Vaccine Pneumococcal Conjugate Vaccine An active immunizing vaccine used to prevent infection by the bacterium Streptococcus pneumoniae. It consists of a solution of saccharides of the capsular antigens of Streptococcus serotypes individually conjugated to proteins. C1455 Conjugate Vaccine C90259 NICHD Pediatric Terminology C1643 Pneumococcal Polyvalent Vaccine Pneumococcal Polyvalent Vaccine Pneumococcal 23-valent Polysaccharide Vaccine An polyvalent vaccine used to prevent infection by the bacterium Streptococcus pneumoniae. Pneumococcal polyvalent vaccine contains highly purified capsular antigens from the 23 most prevalent or invasive pneumococcal types of Streptococcus pneumoniae to ensure cross-protection. Following vaccination, protective capsular type-specific antibody levels typically develop by the third week; serotype-specific antibody levels generally decline after 5-10 years. C97125 Polysaccharide Vaccine C90259 NICHD Pediatric Terminology C3333 Pneumonia Pneumonia An acute, acute and chronic, or chronic inflammation focally or diffusely affecting the lung parenchyma, due to infections (viruses, fungi, mycoplasma, or bacteria), treatment (e.g. radiation), or exposure (inhalation) to chemicals. Symptoms include cough, shortness of breath, fevers, chills, chest pain, headache, sweating, and weakness. A condition resulting from infection in one or both lungs. C3198 Lung Disorder C90259 NICHD Pediatric Terminology C81297 Point in Time Test Given Point in Time Test Given The hour, minute, and/or second that an examination was administered. C25207 Time C90259 NICHD Pediatric Terminology C96409 Polio Vaccination Polio Vaccination The administration a series of either live or inactivated poliovirus for the prophylaxis of poliomyelitis. C15258 Immunization C90259 NICHD Pediatric Terminology C35550 Acute Poliomyelitis Poliomyelitis Polio An acute infectious disorder that affects the nervous system. It is caused by the poliovirus. The virus spreads by direct contact, and can be prevented by prophylaxis with the polio vaccine. C96411 Pediatric Viral Infection C90259 NICHD Pediatric Terminology C14259 Poliovirus Poliovirus An enterovirus comprised of an single-stranded positive sense RNA genome and a protein capsid. This virus is the human pathogen that causes poliomyelitis. C14283 Virus C90259 NICHD Pediatric Terminology C87110 Polydactyly Polydactyly A congenital abnormality characterized by more than 5 digits on a hand or foot. C89337 Congenital Musculoskeletal Defect C90259 NICHD Pediatric Terminology C97125 Polysaccharide Vaccine Polysaccharide Vaccine A category of vaccines that use the extracted and purified outer polysaccharide coat of the particular bacteria. C923 Vaccine C90259 NICHD Pediatric Terminology C2848 Polyvalent Vaccine Polyvalent Vaccine A vaccine designed to elicit an immune response either to more than one infectious agent or to several different antigenic determinants of a single agent. C923 Vaccine C90259 NICHD Pediatric Terminology C87111 Poor Feeding Poor Feeding Occurs either when an infant shows no interest in feeding or when there is an inability to take in adequate nutrition. Poor feeding is a nonspecific symptom of many disorders, including neurological, genetic, structural, metabolic, and infectious diseases. A non-specific symptom characterized by inadequate oral nutritional intake that may be associated with several different disorders. C100104 Sign or Symptom C90259 NICHD Pediatric Terminology C89519 Popliteal Angle Measurement Popliteal Angle Measurement An examination whereby the patient is placed supine, the hip is flexed 90 degrees, and the knee is extended until firm resistance is met. The popliteal angle is the angle from the tibia to the femur. This measurement is used to assess hamstring contracture in children with cerebral palsy. C84749 Newborn Examination C90259 NICHD Pediatric Terminology C25621 Postal Code Postal Code Any system designed to expedite the sorting and delivery of mail by assigning a series of alphanumeric codes to each delivery area. Also used to refer to any individual delivery area code. C16495 Demographics C90259 NICHD Pediatric Terminology C3389 Post-Traumatic Stress Disorder Post-Traumatic Stress Disorder An anxiety disorder precipitated by an experience of intense fear or horror while exposed to a traumatic (especially life-threatening) event. The disorder is characterized by intrusive recurring thoughts or images of the traumatic event; avoidance of anything associated with the event; a state of hyperarousal and diminished emotional responsiveness. These symptoms are present for at least one month and the disorder is usually long-term. C2878 Anxiety Disorder C90259 NICHD Pediatric Terminology C48531 Pound Pound The traditional unit of mass. By international agreement, one avoirdupois pound is equal to exactly 0.453 592 37 kilogram, 16 ounces, or 1.215 28 troy pounds. C25709 Unit of Measure C90259 NICHD Pediatric Terminology C85021 Preeclampsia Preeclampsia A systolic blood pressure of 140 mmHg or higher, or a diastolic blood pressure of 90 mmHg or higher on two occasions at least 4 hours apart (or greater than or equal to 160/110 mmHg within a short interval) after 20 weeks of gestation in a woman with previously normal blood pressure. It may present with proteinuria but if not, it may be associated with thrombocytopenia, impaired liver function, progressive renal insufficiency, pulmonary edema, or new-onset cerebral or visual disturbances. A systolic blood pressure of 140 mmHg or higher, or a diastolic blood pressure of 90 mmHg or higher on two occasions at least 4 hours apart (or greater than or equal to 160/110 mmHg within a short interval) after 20 weeks of gestation in a woman with previously normal blood pressure. It may present with proteinuria but if not, it may be associated with thrombocytopenia, impaired liver function, progressive renal insufficiency, pulmonary edema, or new-onset cerebral or visual disturbances. C4371 Gestational Hypertension C90259 NICHD Pediatric Terminology C34941 Pregnancy Complication Pregnancy Complication The co-occurrence of pregnancy and a disease. The disease may precede or follow conception and it may or may not have a deleterious effect on the pregnant woman or fetus. C2959 Complication C90259 NICHD Pediatric Terminology C87113 Premature Rupture of Membrane Premature Rupture of Membranes PROM Spontaneous rupture of fetal membranes that occurs before the onset of labor. If rupture occurs before 37 weeks of gestation then the correct diagnosis is preterm premature rupture of membranes. Spontaneous rupture of fetal membranes that occurs before the onset of labor. If rupture occurs before 37 weeks of gestation then the correct diagnosis is preterm premature rupture of membranes. C34941 Pregnancy Complication C90259 NICHD Pediatric Terminology C49642 Preterm Infant Preterm Infant Preterm Newborn Infant A newborn infant less than 37 weeks, 0 days gestational age. A newborn infant less than 37 weeks, 0 days gestational age. C16731 Newborn C90259 NICHD Pediatric Terminology C89888 Preterm Neonatal Stage Preterm Neonatal Stage A human life stage that begins at birth prior to thirty-seven weeks of full gestation (full term) and continues until twenty-seven complete days after birth. A human life stage that begins at birth prior to thirty-seven weeks of full gestation (full term) and continues until twenty-seven complete days after birth. C89887 Full Term Neonatal Stage C90259 NICHD Pediatric Terminology C20189 Property or Attribute Property or Attribute A distinguishing quality or prominent aspect of a person, object, action, process, or substance. C89505 Prenatal and Pediatric Terminology C90259 NICHD Pediatric Terminology C87114 Proptosis Proptosis Abnormal protrusion of one or both eyes from the socket; causes include hyperthyroidism (particularly Graves disease); bleeding behind the eye; infection, inflammation, or tumors of the orbit; and vascular disorders. C99208 Eye Finding C90259 NICHD Pediatric Terminology C2893 Psychiatric Disorder Psychiatric Disorder A disorder characterized by behavioral and/or psychological abnormalities, often accompanied by physical symptoms. The symptoms may cause clinically significant distress or impairment in social and occupational areas of functioning. Representative examples include anxiety disorders, cognitive disorders, mood disorders and schizophrenia. C96413 Brain Disorder C90259 NICHD Pediatric Terminology C87130 Pterygium Colli Pterygium Colli A congenital, usually bilateral, thick web-like fold of skin that extends from the acromion to the mastoid process. This deformity is associated with Turner Syndrome and Noonan Syndrome. C97174 Congenital Skin Disorder C90259 NICHD Pediatric Terminology C49676 Pulse Rate Pulse Rate The rate of the pulse as observed in an artery, expressed as beats per minute. It can be measured at several anatomical sites, including the wrist, neck, temple, groin, behind the knees, or on top of the foot. C35552 Cardiovascular System Finding C90259 NICHD Pediatric Terminology C87107 Pupils Equal Round and Reactive to Light Pupils Equal Round and Reactive to Light Pupils Equal Round and Reactive to Light Result While performing an assessment of the eyes, the examiner notes whether the pupils are equal, round, and reactive to light. If all findings are normal, the abbreviation PERRL is noted in the examiner's account of the physical examination. C36280 C90259 NICHD Pediatric Terminology C87108 Pupils Equal Round and Reactive to Light and Accommodation Pupils Equal Round and Reactive to Light and Accommodation Pupils Equal Round and Reactive to Light and Accommodation Result While performing an assessment of the eyes, the examiner notes whether the pupils are equal and round, reactive to light, and have the ability to accommodate. If all findings are normal, the abbreviation PERRLA is noted in the examiner's account of the physical examination. C36280 C90259 NICHD Pediatric Terminology C92722 Qualitative Concept Qualitative Concept A measurement expressed in words rather than numbers. C20189 Property or Attribute C90259 NICHD Pediatric Terminology C70766 Quantitative Concept Quantitative Concept Capable of being estimated or expressed with numeric values. C20189 Property or Attribute C90259 NICHD Pediatric Terminology C17049 Race Race An arbitrary classification of a taxonomic group that is a division of a species. It usually arises as a consequence of geographical isolation within a species and is characterized by shared heredity, physical attributes and behavior, and in the case of humans, by common history, nationality, or geographic distribution. C16495 Demographics C90259 NICHD Pediatric Terminology C38013 Range Range The difference between the lowest and highest numerical values; the limits or scale of variation. C70766 Quantitative Concept C90259 NICHD Pediatric Terminology C1572 Recombinant Viral Vaccine Recombinant Viral Vaccine A vaccine produced from genetically engineered viral vector by introduction of foreign genetic materials to activate immune response in a host. C923 Vaccine C90259 NICHD Pediatric Terminology C12390 Rectum Rectum The terminal portion of the gastrointestinal tract, extending from the rectosigmoid junction to the anal canal. C32221 Body Part C90259 NICHD Pediatric Terminology C81283 Red Reflex Test Red Reflex Test Red Reflex Vision Test An optic examination in which an ophthalmoscope or retinoscope is placed approximately 30cm from the eye to visualize whether a reddish hue is reflected from the retina. An optic examination in which an ophthalmoscope or retinoscope is placed in front of the eye to determine whether a circular reddish hue is visible. C84749 Newborn Examination C90259 NICHD Pediatric Terminology C4077 Redness Redness Coloration of the skin; sign of inflammation C100104 Sign or Symptom C90259 NICHD Pediatric Terminology C52582 Referral Referral Sending a patient from one practitioner to another for health care services. C49236 Therapeutic Procedure C90259 NICHD Pediatric Terminology C81319 Reflex Irritability Score Reflex Irritability Score A component of the Apgar score, it is the numerical value assigned to the neonate's response to stimuli, such as a mild pinch. 0 = no reaction; 1 = grimace; 2 = grimace with a cough, sneeze, or vigorous cry. A component of the Apgar score, it is the numerical value assigned to the neonate's response to tactile stimuli. 0 = no reaction; 1 = grimace; 2 = grimace with a cough, sneeze, or vigorous cry. C118807 C90259 NICHD Pediatric Terminology C64381 Regional Anesthesia Procedure Regional Anesthesia Procedure The administration of pharmaceutical agents intended to produce loss of sensation in a particular anatomical region. C15181 Anesthesia Procedure C90259 NICHD Pediatric Terminology C50726 Regurgitation Regurgitation Flow in the opposite direction from normal, as the casting up of undigested food or gas from the stomach, or the backward flowing of blood into the heart, or between the chambers of the heart when a valve is incompetent. C100104 Sign or Symptom C90259 NICHD Pediatric Terminology C4875 Reproductive System Disorder Reproductive System Disorder A non-neoplastic or neoplastic disorder that affects the male or female genital system. Representative examples of non-neoplastic disorders include infection, testicular torsion, endometriosis, and adenomyosis. Representative examples of neoplastic disorders include germ cell tumors, carcinoma, lymphoma, and sarcoma. C2991 Disease or Disorder C90259 NICHD Pediatric Terminology C81284 Residential Telephone Number Residential Telephone Number The sequence of numbers or characters, that when dialed, connects to a particular residential telephone. C40978 Telephone Number C90259 NICHD Pediatric Terminology C49678 Respiratory Rate Respiratory Rate The rate of breathing (inhalation and exhalation) measured within in a unit time, usually expressed as breaths per minute. C45233 Respiratory System Finding C90259 NICHD Pediatric Terminology C26871 Respiratory System Disorder Respiratory System Disorder A non-neoplastic or neoplastic disorder that affects the respiratory system. Representative examples include pneumonia, chronic obstructive pulmonary disease, pulmonary failure, lung adenoma, lung carcinoma, and tracheal carcinoma. C2991 Disease or Disorder C90259 NICHD Pediatric Terminology C34982 Retinopathy of Prematurity Retinopathy of Prematurity A bilateral retinopathy characterized by neovascularization, scarring, retinal detachment, and eventually blindness. It may be mild or severe. It occurs in babies born prematurely. Causes include oxygen toxicity and hypoxia. A retinal condition of very immature infants that may be characterized by non-vascularized retina that may lead to neovascularization, scarring, retinal detachment, and blindness.|A vasoproliferative condition of very immature newborn infants that may be characterized by non-vascularized retina leading to neovascularization, scarring, retinal detachment, and eventually blindness. C98996 Neonatal Disorder C62601 Retinopathy C90259 NICHD Pediatric Terminology C75488 Rett Syndrome Rett Syndrome A progressive neurologic disorder caused by mutations in the MECP2 gene on chromosome X. It almost exclusively affects girls. It is characterized by language and learning difficulties, poor communication skills, and repetitive hand motions. Other signs and symptoms include microcephaly, scoliosis, breathing abnormalities, and sleep disturbances. C97179 Pervasive Developmental Disorder C90259 NICHD Pediatric Terminology C92947 Rh Immune Globulin Administration Rh Immune Globulin Administration Rho(D) Immune Globulin Administration The administration of Rh Immune Globulin to a pregnant mother to ameliorate the effects of conflicting Rh factors during pregnancy. C49236 Therapeutic Procedure C90259 NICHD Pediatric Terminology C87116 Rhonchi Rhonchi An abnormal sound similar to snoring heard on auscultation of the bronchial airways, suggesting a partial obstruction due to thick secretions, a muscular spasm, or a neoplasm. C100104 Sign or Symptom C90259 NICHD Pediatric Terminology C81285 Right Ear Right Ear The organ of hearing located on the right side of the head. C12394 Ear C90259 NICHD Pediatric Terminology C90498 Risk Factor Assessment Risk Factor Assessment A systematic gathering of information regarding the variables associated with an individual's increased risk of disease or infection. C25214 Evaluation Procedure C90259 NICHD Pediatric Terminology C81320 Rooting Reflex Rooting Reflex An involuntary, primal response in the neonate to search for the nipple when the cheek is touched. An involuntary response in the neonate to search for the nipple when the cheek is touched, that disappears by 3-4 months of age. C81181 Infant Reflex C90259 NICHD Pediatric Terminology C77199 Rotavirus Rotavirus A genus of double stranded RNA viruses that carry 11 unique double helix molecules of RNA that encode one or two proteins each. The RNA is surrounded by a three-layered icosahedral protein capsid. Viral particles are up to 76.5 nm in diameter and are not enveloped. C14283 Virus C90259 NICHD Pediatric Terminology C96394 Rotavirus Vaccine Rotavirus Vaccine A viral vaccine that prevents against rotavirus infection, the leading cause of severe acute gastroenteritis. C1920 Attenuated Live Virus Vaccine C90259 NICHD Pediatric Terminology C38114 Route of Administration Route of Administration Designation of the part of the body through which or into which, or the way in which, the medicinal product is intended to be introduced. In some cases a medicinal product can be intended for more than one route and/or method of administration. C25218 Intervention or Procedure C90259 NICHD Pediatric Terminology C92872 Rubella Immunization Rubella Immunization The administration of a live attenuated viral vaccine to prevent rubella infection. C15258 Immunization C90259 NICHD Pediatric Terminology C85051 Rubella Infection Rubella Infection German Measles A viral infection caused by the rubella virus. It is initially manifested with flu-like symptoms that last one or two days, followed by the development of a characteristic red rash which lasts from one to five days. The rash first appears in the neck and face. It subsequently spreads to the rest of the body. C3439 Viral Infection C90259 NICHD Pediatric Terminology C87118 Sacral Dimple Sacral Dimple A small hollow area or sinus present at birth and located just above the crease of the buttocks. In most cases, pilonidal dimples are benign and may just be accompanied by increased hair growth in the area. A blind-ending, epithelial-lined tract that is located 5-25 mm from the anal verge. C100104 Sign or Symptom C90259 NICHD Pediatric Terminology C81288 S-Beta Thalassemia S-Beta Thalassemia A disorder characterized by the body's inability to synthesize beta-globin chains, leading to the formation of abnormal hemoglobin and anemia. This inherited autosomal recessive blood disorder is caused by germline mutation of the HBB gene. C35069 Thalassemia C90259 NICHD Pediatric Terminology C89521 Scarf Sign Scarf Sign When testing the newborn infant for neuromuscular maturity, the "scarf sign" test is carried out by drawing the newborn's arm across the chest to the opposite shoulder until resistance is felt. In term infants, the elbow should not cross the midline of the chest. C84749 Newborn Examination C90259 NICHD Pediatric Terminology C78603 Scoliosis Scoliosis A congenital or acquired spine deformity characterized by lateral curvature of the spine. C99064 Spinal Deformity C90259 NICHD Pediatric Terminology C2962 Seizure Seizure Sudden, involuntary skeletal muscular contractions of cerebral or brain stem origin. A paroxysmal surge of electrical activity in the brain that may result in physical or behavioral changes. C87124 Central Nervous System Signs and Symptoms C90259 NICHD Pediatric Terminology C3020 Seizure Disorder Seizure Disorder Epilepsy A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions. A neurological disorder characterized by recurring seizures. C96413 Brain Disorder C90259 NICHD Pediatric Terminology C92569 Selective Mutism Selective Mutism A persistent failure to speak in certain social situations (i.e., school) where speaking is expected, despite speaking in other situations. C2878 Anxiety Disorder C90259 NICHD Pediatric Terminology C26739 Sensorineural Hearing Loss Sensorineural Hearing Loss Hearing loss resulting from damage to the cochlea, auditory nerve and/or brainstem. A type of hearing impairment due to abnormal functioning of the hair cells of the cochlea, the vestibulocochlear nerve, or the central processing centers of the brain.|Hearing loss resulting from damage to the cochlea, auditory nerve and/or brainstem. C35731 Hearing Loss C90259 NICHD Pediatric Terminology C63711 Sensory Disorder Sensory Disorder An interruption or alteration in the sensory activity or functions of the nervous system. C2991 Disease or Disorder C90259 NICHD Pediatric Terminology C35014 Separation Anxiety Disorder Separation Anxiety Disorder An anxiety disorder characterized by recurrent excessive distress due to fear of separation from the home or from major attachment figures; the distress is developmentally inappropriate and causes impairment in social, academic, or other areas of functioning. C92190 Pediatric Psychiatric Disorder C90259 NICHD Pediatric Terminology C3364 Septicemia Sepsis The presence of pathogenic microorganisms in the blood stream causing a rapidly progressing systemic reaction that may lead to shock. Symptoms include fever, chills, tachycardia, and increased respiratory rate. It is a medical emergency that requires urgent medical attention. A systemic inflammatory response to an infection.|Clinical syndrome defined by the presence of both infection and a systemic inflammatory response. C2890 Bacterial Disease C90259 NICHD Pediatric Terminology C28421 Sex Sex The assemblage of physical properties or qualities by which male is distinguished from female; the physical difference between male and female; the distinguishing peculiarity of male or female. C25447 Characteristic C90259 NICHD Pediatric Terminology C25203 Shoulder Shoulder The region of the body between the neck and the upper arm. C32221 Body Part C90259 NICHD Pediatric Terminology C81290 Shoulder Dystocia Shoulder Dystocia A birth complication caused by impaction of the anterior shoulder against the maternal symphysis pubis that requires additional maneuvers to relieve impaction of the fetal shoulder and allow for delivery. A birth complication caused by impaction of the anterior shoulder against the maternal symphysis pubis that requires additional maneuvers to relieve impaction of the fetal shoulder and allow for delivery. C81236 Birth Complication C90259 NICHD Pediatric Terminology C81291 Sick Newborn Sick Newborn A neonate that is unwell. C16731 Newborn C90259 NICHD Pediatric Terminology C34383 Sickle Cell Disease Sickle Cell Disease A blood disorder characterized by the appearance of sickle-shaped red blood cells and anemia. C3092 Hemoglobinopathy C90259 NICHD Pediatric Terminology C100104 Sign or Symptom Sign or Symptom Signs or Symptoms Objective evidence of disease perceptible to the examining practitioner (sign) and subjective evidence of disease perceived by the patient (symptom). C3367 Finding C90259 NICHD Pediatric Terminology C87120 Single Palmar Crease Single Palmar Crease A single transverse palmar crease is found in 5% of newborns and is frequently inherited as a familial trait. However, single palmar creases can be associated with Down's syndrome and other genetic disorders, or with fetal alcohol syndrome. C100104 Sign or Symptom C90259 NICHD Pediatric Terminology C87121 Situs Inversus Situs Inversus A congenital condition in which there is complete right-to-left reversal of the position of the major thoracic and abdominal organs (that is, they are arranged in a mirror image of the normal positioning). C97151 Congenital Systemic Disorder C90259 NICHD Pediatric Terminology C81321 Skin Color Score Skin Color Score A component of the Apgar score, it is the numerical value assigned to an assessment of the color of the skin of a neonate. 0 = pale blue; 1 = pink body and pale blue extremities; 2 = pink body and extremities. A component of the Apgar score, it is the numerical value assigned to an assessment of the color of the skin of a neonate. 0 = blue; 1 = pink body and blue extremities; 2 = pink body and extremities. C36281 Integumentary System Finding C90259 NICHD Pediatric Terminology C3371 Skin Disorder Skin Disorder Integumentary System Disorder Any deviation from the normal structure or function of the skin or subcutaneous tissue that is manifested by a characteristic set of symptoms and signs. C2991 Disease or Disorder C90259 NICHD Pediatric Terminology C39594 Skin Rash Skin Rash Any change in the skin which affects its appearance or texture. A rash may be localized to one part of the body, or affect all the skin. Rashes may cause the skin to change color, itch, become warm, bumpy, dry, cracked or blistered, swell and may be painful. An eruption in the skin which affects its appearance or texture. C36281 Integumentary System Finding C100104 Sign or Symptom C90259 NICHD Pediatric Terminology C73425 Sleep Sleep A natural and periodic state of rest during which consciousness of the world is suspended. C16326 Behavior C90259 NICHD Pediatric Terminology C3376 Sleep Disorder Sleep Disorder A change from the patient's baseline sleeping pattern, either an increase or a decrease in the number of hours slept. This can also refer to alterations in the stages of sleep. C26835 Nervous System Disorder C90259 NICHD Pediatric Terminology C98828 Small Intestine Atresia Small Intestine Atresia Atresia of Small Intestine A congenital malformation characterized by the absence of a normal opening in a part of the small intestine. C97171 Congenital Gastrointestinal Disorder C90259 NICHD Pediatric Terminology C29719 Smoking History Smoking History A record of an individual's background in regard to smoking tobacco. This would include such factors as start date, end date (if applicable), number of cigarette smoked, attempts to quit, and others. C18772 Personal Medical History C90259 NICHD Pediatric Terminology C50746 Sneezing Sneezing A symptom consisting of the involuntary expulsion of air from the nose. The involuntary expulsion of air from the nose. C100104 Sign or Symptom C90259 NICHD Pediatric Terminology C34927 Social Anxiety Disorder Social Anxiety Disorder An anxiety disorder characterized by an intense, irrational fear of one or more social or performance situations in which the individual believes that he or she will be scrutinized by others. Exposure to social situations immediately provokes an anxiety response. In adults, the social phobia is recognized as excessive or unreasonable. C2878 Anxiety Disorder C90259 NICHD Pediatric Terminology C81292 Social History Social History Past events that occurred between individuals and/or their communities. C18772 Personal Medical History C90259 NICHD Pediatric Terminology C34781 Spastic Diplegia Spastic Diplegia A type of cerebral palsy characterized by spasticity and hypertonia of the lower extremities bilaterally, particularly the legs, hips, and pelvis; this is the most common (70%) form of cerebral palsy. A type of spastic cerebral palsy characterized by increased muscle tone of the lower extremities bilaterally, particularly the legs, hips, and pelvis. C34460 Cerebral Palsy C90259 NICHD Pediatric Terminology C35284 Specific Phobia Specific Phobia An anxiety disorder characterized by an intense, irrational fear cued by the presence or anticipation of a specific object or situation. Exposure to the phobic stimulus immediately provokes an anxiety response. In adults, the specific phobia is recognized as excessive or unreasonable. C2878 Anxiety Disorder C90259 NICHD Pediatric Terminology C5041 Speech Disorder Speech Disorder A term referring to disorders characterized by the disruption of normal speech. It includes stuttering, lisps, dysarthria and voice disorders. C26835 Nervous System Disorder C90259 NICHD Pediatric Terminology C89520 Square Window Square Window When testing the newborn infant for neuromuscular maturity, the "square window" test measures wrist flexibility and resistance to extensor stretching, The examiner straightens the infant's fingers and applies gentle pressure on the dorsum of the hand, close to the fingers, and then estimates the angle between the palm of the hand and the forearm. C84749 Newborn Examination C90259 NICHD Pediatric Terminology C81322 Step Reflex Step Reflex An involuntary, primal response in the neonate to take brisk steps when the feet are placed on a surface whilst in a supported standing position. C81181 Infant Reflex C90259 NICHD Pediatric Terminology C35040 Strabismus Strabismus Strabismus is the intermittent or constant misalignment of an eye so that its line of vision is not pointed at the same object as the other eye. Strabismus is caused by an imbalance in the extraocular muscles which control the positioning of the eyes. Strabismus is normal in newborns but should resolve by the time the baby is 6 months old. In older children with strabismus, the brain may learn to ignore the input from one eye, and this may lead to amblyopia, a potentially permanent decrease in vision in that eye if not corrected. C26767 C90259 NICHD Pediatric Terminology C81293 Street Number Street Number The numeric or alphabetic identifier of a building on a thoroughfare. C16495 Demographics C90259 NICHD Pediatric Terminology C38299 Subcutaneous Route of Administration Subcutaneous Route of Administration Drug administration beneath the skin. It provides for relatively slow, sustained release of the drug. The rate of absorption into the blood is perfusion-limited, proportional to the amount of drug at the site and can be enhanced by chemical or physical stimulation of blood flow. Subcutaneous administration minimizes the risks associated with intravascular injection: for subcutaneous infusions, external and implantable pumps are used. C38291 Parenteral Route of Administration C90259 NICHD Pediatric Terminology C81294 Submitting Facility Submitting Facility The hospital or medical institution that is submitting data or information. C16495 Demographics C90259 NICHD Pediatric Terminology C45306 Substance Substance Any matter of defined composition that has discrete existence, whose origin may be biological, mineral or chemical. C89505 Prenatal and Pediatric Terminology C90259 NICHD Pediatric Terminology C81323 Sucking Reflex Sucking Reflex An involuntary, primal response in the neonate when a nipple is placed on an infant's lips. An involuntary response in the neonate when a nipple is placed on an infant's lips to rhythmically suck, that disappears by 2-5 months of age. C81181 Infant Reflex C90259 NICHD Pediatric Terminology C36172 Sweating Sweating A watery secretion by the sweat glands that is primarily composed of salt, urea and minerals. C100104 Sign or Symptom C90259 NICHD Pediatric Terminology C87125 Syndactyly Syndactyly A congenital condition characterized by webbing between the fingers and/or toes, joining the digits together. In rare cases, the joining of the fingers or toes may involve bony fusion between the digits. Common causes include Down Syndrome and hereditary syndactyly. C89337 Congenital Musculoskeletal Defect C90259 NICHD Pediatric Terminology C9229 Systemic Disease Systemic Disorder A clinical course finding indicating that a disease presents with systemic manifestations. A disorder that affects in multiple tissue types or in multiple organ systems, or affects the body as a whole. C2991 Disease or Disorder C90259 NICHD Pediatric Terminology C40978 Telephone Number Telephone Number A sequence of decimal digits (0-9) that is used for identifying a destination telephone line or other device in a telephone network. C90492 Personal Information C90259 NICHD Pediatric Terminology C25206 Temperature Temperature A measure of the average kinetic energy of a system of particles. Temperature may be quantified, in the context of thermodynamics, as the potential of one system to transfer thermal energy to another system until both systems reach a state of thermal equilibrium. C25447 Characteristic C90259 NICHD Pediatric Terminology C21514 Temporal Qualifier Temporal Qualifier Terms used to indicate units of time or other terms associated with time. C20189 Property or Attribute C90259 NICHD Pediatric Terminology C89333 Term Infant Term Infant Full Term Neonate A newborn infant greater than or equal to 37 weeks, 0 days and less than or equal to 41 weeks, 6 days gestational age. A newborn infant greater than or equal to 37 weeks, 0 days and less than or equal to 41 weeks, 6 days gestational age. C16731 Newborn C90259 NICHD Pediatric Terminology C85185 Tetanus Tetanus A serious infectious disorder that follows wound contamination by the Gram-positive bacterium Clostridium tetani. The bacteria produce a neurotoxin called tetanospasmin, which causes muscle spasm in the jaw and other anatomic sites. C2890 Bacterial Disease C90259 NICHD Pediatric Terminology C96405 Tetanus and Diphtheria Toxoids Adsorbed Tetanus and Diphtheria Toxoids Adsorbed A sterile, intramuscular suspension of alum (aluminum potassium sulfate)-precipitated toxoids indicated for active immunization for the prevention of tetanus and diphtheria for use in persons 7 years of age or older. C96398 Toxoid Vaccine C90259 NICHD Pediatric Terminology C2660 Tetanus Toxoid Vaccine Tetanus Toxoid Vaccine A preparation of formaldehyde-deactivated toxin isolated from the bacterium Clostridium tetani. Tetanus toxoid is used for booster injection and can stimulate the production of antitoxin antibodies. This agent may be used as an adjuvant in cancer vaccines. C96398 Toxoid Vaccine C90259 NICHD Pediatric Terminology C49236 Therapeutic Procedure Therapeutic Procedure An action or administration of therapeutic agents to produce an effect that is intended to alter or stop a pathologic process. C25218 Intervention or Procedure C90259 NICHD Pediatric Terminology C12799 Thorax Thorax The division of the body lying between the neck and the abdomen. C32221 Body Part C90259 NICHD Pediatric Terminology C84479 Thrombophilia Thrombophilia A condition characterized by an abnormally high level of thrombi. Causes include thrombotic thrombocytopenic purpura, disseminated intravascular coagulation, bone marrow disorders, and antiphospholipid antibody syndrome. Abnormally increased tendency of the blood to form clots. C2902 Coagulation Defect|Coagulopathy C90259 NICHD Pediatric Terminology C85189 Thyroglossal Duct Cyst Thyroglossal Duct Cyst A congenital benign cyst arising from the remnants of the thyroglossal duct. It is usually located in the midline of the neck. C2978 Cyst C90259 NICHD Pediatric Terminology C64813 Thyrotropin Measurement Thyrotropin Measurement A quantitative measurement of the amount of thyrotropin present in a sample. C74742 Hormone Measurement C90259 NICHD Pediatric Terminology C25207 Time Time The continuum of experience in which events pass from the future through the present to the past. C20189 Property or Attribute C90259 NICHD Pediatric Terminology C89342 Toddler Toddler A child that is approximately between 12 and 18 months of age. C16423 Child C90259 NICHD Pediatric Terminology C89890 Toddler Stage Toddler Stage The period of life between 13 months and 2 years of age. A human life stage that begins at thirteen months of age and continues until twenty-four complete months of age. C89345 Childhood C90259 NICHD Pediatric Terminology C33788 Toe Toe One of the terminal digits of the foot. C32221 Body Part C90259 NICHD Pediatric Terminology C81324 Tonic Neck Reflex Tonic Neck Reflex An involuntary, primal response in the neonate in which the arm extends to follow the infant's gaze, while the opposing arm and leg flex inward. An involuntary response in the neonate in which the arm extends to follow the infant's gaze, while the opposing arm and leg flex inward, that disappears by 4-6 months of age. C81181 Infant Reflex C90259 NICHD Pediatric Terminology C81298 Total Body Length Total Body Length The total linear extent of the body. The total linear extent of the body measured from the crown of the head to the heel in the recumbent position. C25334 Length C90259 NICHD Pediatric Terminology C74794 Total Thyroxine Measurement Total Thyroxine Measurement The determination of the amount of free and bound thyroxine present in a sample. C74742 Hormone Measurement C90259 NICHD Pediatric Terminology C35078 Tourette Syndrome Tourette Syndrome Tourette's Syndrome A neurologic disorder caused by defective metabolism of the neurotransmitters in the brain. It is characterized by repeated involuntary movements (motor tics) and uncontrollable vocal sounds (vocal tics). The symptoms are usually manifested before the age of eighteen. A neurological disorder presenting in childhood that is characterized by both motor and phonic tics that occur daily or nearly daily for at least a year and are not attributed to an identifiable cause. C96412 Brain Development Abnormality C116757 Movement Disorders C90259 NICHD Pediatric Terminology C96398 Toxoid Vaccine Toxoid Vaccine Any vaccine that contains an inactivated toxic substance used for disease prophylaxis or to vaccinate against snake bites. C923 Vaccine C90259 NICHD Pediatric Terminology C81325 Transferase Deficiency Galactosemia Transferase Deficiency Galactosemia Transferase Deficient Galactosemia A disorder characterized by the body's inability to metabolize galactose. This type of galactosemia is caused by germline mutations in the GALT gene which leads to the inhibition in the activity of the enzyme galactose-1-phosphate uridyl transferase. C34816 Congenital Metabolic Disorder C90259 NICHD Pediatric Terminology C38038 Tremor Tremor The shaking movement of the whole body or just a certain part of it, often caused by problems of the neurons responsible for muscle action. Unintentional trembling or shaking of one or more body parts. C100104 Sign or Symptom C90259 NICHD Pediatric Terminology C2643 Trivalent Influenza Vaccine Trivalent Influenza Vaccine Flu prevention|Flu prophylaxis|Flu shot|Flu vaccination A synthetic vaccine consisting of three inactivated influenza viruses, two different influenza type A strains and one influenza type B strain. Trivalent influenza vaccine is formulated annually, based on influenza strains projected to be prevalent in the upcoming flu season. This agent may be formulated for injection or intranasal administration. C2848 Polyvalent Vaccine C90259 NICHD Pediatric Terminology C97126 Ty21a Typhoid Vaccine Ty21a Typhoid Vaccine A live attenuated oral virus vaccine used to prevent typhoid, which is caused by Salmonella typhi. C62761 Attenuated Bacteria Vaccine C90259 NICHD Pediatric Terminology C35089 Typhoid Fever Typhoid Fever A bacterial infectious disorder contracted by consumption of food or drink contaminated with Salmonella typhi. This disorder is common in developing countries and can be treated with antibiotics. C2890 Bacterial Disease C90259 NICHD Pediatric Terminology C17230 Ultrasonography Ultrasonography Ultrasound Imaging|Ultrasound A technique in which high-frequency sound waves are bounced off internal organs and the echo pattern is converted into a 2 dimensional picture of the structures beneath the transducer. C18020 Diagnostic Procedure C90259 NICHD Pediatric Terminology C87126 Umbilical Cord Prolapse Umbilical Cord Prolapse Prolapsed Cord A situation in which the umbilical cord is ahead of the presenting fetal part. If the cord becomes compressed it may cut off the flow of blood to the baby. Passage of the umbilical cord through the cervix before the fetus during delivery. C81236 Birth Complication C90259 NICHD Pediatric Terminology C12326 Undescended Testes Undescended Testes Undescended Testis The failure of one or both testes of a male fetus to descend from the abdomen into the scrotum during the late part of pregnancy. If not surgically corrected in early childhood, males may be at increased risk for testicular cancer later in life. C103185 Congenital Reproductive System Abnormality C27019 Male Reproductive System Disorder C90259 NICHD Pediatric Terminology C25709 Unit of Measure Unit of Measure A named quantity in terms of which other quantities are measured or specified, used as a standard measurement of like kinds. C20189 Property or Attribute C90259 NICHD Pediatric Terminology C77606 Unit per Gram Unit per Gram An arbitrary unit of substance content expressed in unit(s) per gram. C25709 Unit of Measure C90259 NICHD Pediatric Terminology C30010 US State US State One of the fifty states which is a member of the federation known as the United States of America. Other US geographic areas, such as Puerto Rico and the District of Columbia, are essentially equivalent to State when used in an address. C16495 Demographics C90259 NICHD Pediatric Terminology C923 Vaccine Vaccine Preparations containing substances with antigenic properties administered to activate the immune system, thereby inducing an immune response. C307 Biologic Agent C90259 NICHD Pediatric Terminology C81300 Vacuum Assisted Vaginal Delivery Vacuum Assisted Vaginal Delivery Application of a vacuum device to the fetal head to facilitate vaginal birth. Application of a vacuum device to the fetal head to facilitate vaginal birth. C81301 Vaginal Assisted Delivery C90259 NICHD Pediatric Terminology C81301 Vaginal Assisted Delivery Vaginal Assisted Delivery Birth of the fetus through the vagina with the application of vacuum or forceps or any other instrument. Birth of the fetus through the vagina with the application of vacuum or forceps or any other instrument. C81303 Vaginal Delivery C90259 NICHD Pediatric Terminology C81302 Vaginal Birth after Cesarean Delivery Vaginal Birth after Cesarean Delivery Vaginal Birth after Caesarean|Vaginal Birth after Cesarean A vaginal birth in a woman with one or more previous cesarean births. (reVITALize) A vaginal birth in a woman with one or more previous cesarean births. [verbatim from reVITALize] C81303 Vaginal Delivery C90259 NICHD Pediatric Terminology C81303 Vaginal Delivery Vaginal Delivery Birth of the fetus through the vagina. Birth of the fetus through the vagina. C81179 Delivery Procedure C90259 NICHD Pediatric Terminology C96395 Varicella Vaccine Varicella Vaccine Chickenpox Vaccine|Shingles Vaccine A live attenuated virus vaccine used to prevent chickenpox and shingles, which is caused by varicella-zoster virus (VZV). C1920 Attenuated Live Virus Vaccine C90259 NICHD Pediatric Terminology C71091 Varicella Zoster Virus Varicella Zoster Virus An icosahedral, enveloped virus containing a single molecule of linear double-stranded DNA of 125000 nucleotides that infects only humans. It is the causative agent of chickenpox and shingles. C14283 Virus C90259 NICHD Pediatric Terminology C92915 Varicella Zoster Virus Immunization Varicella Zoster Virus Immunization Chickenpox Immunization The administration of a live attenuated viral vaccine to prevent herpes zoster infection. C15258 Immunization C90259 NICHD Pediatric Terminology C87127 Vasa Previa Vasa Previa Umbilical blood vessels that have inserted into the amniotic membrane (membranous insertion) that in turn are above or adjacent to the cervical os and are at risk of rupture. Umbilical blood vessels that have inserted into the amniotic membrane (membranous insertion) that in turn are above or adjacent to the cervical os and are at risk of rupture. C81236 Birth Complication C90259 NICHD Pediatric Terminology C81184 Vernier Caliper Vernier Caliper A medical device that is a combination of ruler and caliper that can measure the distance between two points. The configuration of this device permits the measurement of internal dimensions. An instrument for measuring external or internal dimensions. It consists of an L-shaped frame with a linear scale along its longer arm and an L-shaped sliding attachment with a vernier, used to read directly the dimension of an object represented by the separation between the inner or outer edges of the two shorter arms. C62103 C90259 NICHD Pediatric Terminology C12998 Vertebral Column Vertebral Column A series of bones, muscles, tendons, and other tissues reaching from the base of the skull to the tailbone. The vertebral column forms the axis of the skeleton and encloses as well as protects the spinal cord and the fluid surrounding the spinal cord. C32221 Body Part C90259 NICHD Pediatric Terminology C97127 Vi Capsular Polysaccharide Typhoid Vaccine Vi Capsular Polysaccharide Typhoid Vaccine A live attenuated injectable virus vaccine used to prevent typhoid, which is caused by Salmonella typhi. C97125 Polysaccharide Vaccine C90259 NICHD Pediatric Terminology C3439 Viral Infection Viral Infection Viral Disease Any disease caused by a virus. C26726 Infectious Disease C90259 NICHD Pediatric Terminology C14283 Virus Virus An infectious agent which consists of two parts, genetic material and a protein coat. These organisms lack independent metabolism, and they must infect the cells of other types of organisms to reproduce. Most viruses are capable of passing through fine filters that retain bacteria, and are not visible through a light microscope. C14250 Organism C90259 NICHD Pediatric Terminology C35126 Vision Disorder Vision Disorder Visual impairments limiting one or more of the basic functions of the eye: visual acuity, dark adaptation, color vision, or peripheral vision. These may result from eye diseases, optic nerve diseases, visual pathway diseases, occipital lobe diseases, ocular motility disorders' and other conditions. C63711 Sensory Disorder C90259 NICHD Pediatric Terminology C35275 Visual Cortex Disorder Visual Cortex Disorder Cortical Visual Impairment A vision disorder that results from damage of the part of the cerebral cortex that is involved in the processing of visual information. C35126 Vision Disorder C90259 NICHD Pediatric Terminology C49672 Vital Signs Measurement Vital Sign Measurement The act of assessing an individual's current temperature, heart rate, respiratory rate, pulse oxygenation, and blood pressure. C18020 Diagnostic Procedure C90259 NICHD Pediatric Terminology C943 Vitamin K Vitamin K The term "vitamin K" refers to a group of chemically similar fat-soluble compounds called naphthoquinones: vitamin K1 (phytonadione) is found in plants and is the primary source of vitamin K for humans through dietary consumption, vitamin K2 compounds (menaquinones) are made by bacteria in the human gut, and vitamin K3 (menadione) is a water-soluble preparation available for adults only. Vitamin K is necessary for the liver to produce the coagulation factors II, VII, IX, and X, as well as the clotting factors protein C, protein S, and protein Z; vitamin K deficiency can result in deficiencies of these coagulation factors and excess bleeding. An injection of vitamin K is routinely given to newborn infants to prevent vitamin K deficiency bleeding, also known as hemorrhagic disease of the newborn. Vitamin K deficiency is rare in adults but may result from chronic malnutrition or an inability to absorb dietary vitamins. C1909 Pharmacologic Substance C90259 NICHD Pediatric Terminology C3442 Vomiting Vomiting Forceful ejection of the contents of the stomach through the mouth. Expulsion of the contents of the stomach through the mouth. C100104 Sign or Symptom C90259 NICHD Pediatric Terminology C87129 Weak Breathing Weak Breathing Shallow inhalations and exhalations that indicate respiratory distress. C100104 Sign or Symptom C90259 NICHD Pediatric Terminology C78718 Wheezing Wheezing A symptom and a finding during physical examination, characterized by a high-pitched, whistling sound during breathing. It results from the narrowing or obstruction of the respiratory airways. The most common causes of wheezing are asthma, chronic obstructive pulmonary disease, tracheobronchitis, and pulmonary edema. A high-pitched breath sound resulting from a narrowing or obstruction of the small airways. C100104 Sign or Symptom C90259 NICHD Pediatric Terminology C87131 Yawning Yawning An involuntary deep inhalation with the mouth open, often a sign of drowsiness or boredom. C100104 Sign or Symptom C90259 NICHD Pediatric Terminology C96396 Yellow Fever Vaccine Yellow Fever Vaccine A live, attenuated viral vaccine to prevent yellow fever, endemic to parts of Africa and South America. C1920 Attenuated Live Virus Vaccine C90259 NICHD Pediatric Terminology C35547 Yellow Fever Virus Infection Yellow Fever Virus Infection A viral infection caused by a flavivirus called yellow fever virus. It is transmitted to humans from infected mosquitoes. The signs and symptoms range from a mild febrile illness to liver damage with jaundice and hemorrhages. C3439 Viral Infection C90259 NICHD Pediatric Terminology C49488 Yes Yes The affirmative response to a question. C25180 Indicator C90259 NICHD Pediatric Terminology