C C45161 Borrelia burgdorferi Infection Lyme Disease Borrelia burgdorferi Infection An infectious disease caused by the spirochete Borrelia burgdorferi. Early manifestations of infection may include fever, headache, fatigue, depression, and a characteristic skin rash called erythema migrans. Left untreated, late manifestations involving the joints, heart, and nervous system can occur. An infectious disease that is caused by the spirochete Borrelia burgdorferi. C26726 Infectious Disorder C118468 Pediatric Rheumatology Terminology