C	C2323	Glucocorticoid	Glucocorticoid		A corticosteroid that supports a variety of cardiovascular, metabolic, immunologic, and homeostatic functions, and which binds specifically to the glucocorticoid receptor (GR; NR3C1). Glucocorticoid binding to GR leads to the transportation of the activated receptor-glucocorticoid complex to the nucleus, after which it binds to glucocorticoid response elements (GRE) and regulates the expression of GR-responsive genes.	A group of corticosteroids that affect carbohydrate metabolism, inhibit corticotropin secretion, and possess pronounced anti-inflammatory activity.	C1909	Pharmacologic Substance			C118468	Pediatric Rheumatology Terminology		
C	C257	Nonsteroidal Antiinflammatory Drug	Nonsteroidal Antiinflammatory Drug	NSAID	A pharmacological agent that is not a steroid and has potential anti-inflammatory, analgesic, antipyretic and anti-platelet activities. Most nonsteroidal anti-inflammatory drugs (NSAIDs) act by inhibiting the conversion of arachidonic acid to the precursors of prostaglandin and thromboxane by cyclooxygenase enzymes.	A class of medication typically used for its analgesic, antipyretic, anti-inflammatory, and/or platelet-inhibitory effects. Effects are classically exerted through inhibition of cyclooxygenase 1 and/or cyclooxygenase 2, though other pharmacologic effects may be involved.	C1909	Pharmacologic Substance			C118468	Pediatric Rheumatology Terminology