C	C114281	Parotitis	Parotitis		Inflammation of the parotid glands.	Inflammation of the parotid glands.	C118420	Otolaryngologic Disorder			C118468	Pediatric Rheumatology Terminology		
C	C118316	Mucosal Ulcer	Mucosal Ulcer		A circumscribed loss of integrity of the mucous membrane.	A circumscribed loss of integrity of the mucous membrane.	C3426	Ulcer			C118468	Pediatric Rheumatology Terminology		
C	C26860	Pleuritis	Pleuritis	Pleurisy	Inflammation of the pleura. It is usually caused by infections. Chest pain while breathing or coughing is the presenting symptom.	Inflammation of the pleura.	C26871	Respiratory System Disorder			C118468	Pediatric Rheumatology Terminology		
C	C26909	Uveitis	Uveitis		An inflammatory process affecting a part of or the entire uvea. Causes include inflammatory agents (e.g., herpes simplex, herpes zoster, leptospirosis) and systemic diseases (e.g., inflammatory bowel disease, multiple sclerosis, systemic lupus erythematosus, ankylosing spondylitis). Patients present with pain and redness in the eye, light sensitivity, and blurred and decreased vision.	Inflammation of the iris, ciliary body, and/or choroid (uveal tract).	C26767	Eye Disorder			C118468	Pediatric Rheumatology Terminology		
C	C2881	Arrhythmia	Arrhythmia	Cardiac Arrhythmia	Any variation from the normal rate or rhythm (which may include the origin of the impulse and/or its subsequent propagation) in the heart.	Any variation from the normal rate or rhythm (which may include the origin of the impulse and/or its subsequent propagation) in the heart.	C78245	Cardiac Conduction Disorder			C118468	Pediatric Rheumatology Terminology		
C	C3090	Hematuria	Hematuria		Blood in the urine.	The presence of red blood cells in the urine.	C3149	Kidney Disease			C118468	Pediatric Rheumatology Terminology		
C	C34399	Arteritis	Arteritis		An inflammatory process affecting an artery.	Inflammation of an artery.	C35117	Vascular Disorder			C118468	Pediatric Rheumatology Terminology		
C	C34831	Myocarditis	Myocarditis		Inflammation of the muscle tissue of the heart.	Inflammation of the myocardium.	C3079	Heart Disease			C118468	Pediatric Rheumatology Terminology		
C	C35109	Anterior Uveitis	Anterior Uveitis		Inflammation of the iris and anterior chamber of the eye.	Inflammation of the anterior uveal tract.	C26909	Uveitis			C118468	Pediatric Rheumatology Terminology		
C	C35111	Posterior Uveitis	Posterior Uveitis		An inflammatory process that affects the choroid.	Inflammation of the posterior uveal tract.	C26909	Uveitis			C118468	Pediatric Rheumatology Terminology		
C	C39594	Skin Rash	Skin Rash	Skin Eruption	Any change in the skin which affects its appearance or texture. A rash may be localized to one part of the body, or affect all the skin. Rashes may cause the skin to change color, itch, become warm, bumpy, dry, cracked or blistered, swell and may be painful.	An eruption in the skin which affects its appearance and/or texture.	C36281	Integumentary System Finding	C100104	Signs or Symptoms	C118468	Pediatric Rheumatology Terminology		
C	C78787	Purpura	Purpura		A small blood vessel hemorrhage into the skin and/or mucous membranes. Newer lesions appear reddish in color. Older lesions are usually a darker purple color and eventually become a brownish-yellow color.	Small blood vessel hemorrhage into the skin and/or mucous membranes presenting as red or purplish patches.	C36281	Integumentary System Finding			C118468	Pediatric Rheumatology Terminology		
C	C84978	Osteochondrodysplasia	Osteochondrodysplasia	Congenital Skeletal Dysplasia	A term referring to disorders characterized by abnormalities in the development of bones and cartilage.	A complex group of bone and cartilage disorders that result in abnormalities in the size and shape of the trunk, extremities, and/or skull.	C89337	Congenital Musculoskeletal Defect			C118468	Pediatric Rheumatology Terminology		
C	C84989	Panuveitis	Panuveitis		A disorder characterized by inflammation of the entire uvea which includes the iris, ciliary body, and choroid. Causes include systemic infections, sarcoidosis, and cancers.	Inflammation of all layers of the uvea.	C26909	Uveitis			C118468	Pediatric Rheumatology Terminology		
C	C116784	Circumscribed Morphea	Circumscribed Morphea		A type of morphea in which the lesions are circular or ovoid, and may be superficial or deep. The superficial lesions can have an indurated, waxy, ivory colored center with surrounding erythema or violaceous color during the active stage. Deep lesions can be sclerotic and depressed from underlying atrophy, and may show minimal skin color changes. When there are several (greater than or equal to 4), larger (greater than 3cm) lesions on two or more body areas this is classified as "generalized morphea".	A type of morphea in which the lesions are circular or ovoid, and may be superficial or deep. The superficial lesions can have an indurated, waxy, ivory colored center with surrounding erythema or violaceous color during the active stage. Deep lesions can be sclerotic and depressed from underlying atrophy, and may show minimal skin color changes. When there are several (greater than or equal to 4), larger (greater than 3 cm) lesions on two or more body areas this is classified as "generalized morphea".	C72069	Morphea			C118468	Pediatric Rheumatology Terminology		
C	C2701	Therapeutic Immune Globulin	Immune Globulin	Gamma Globulin	A preparation of plasma proteins derived from the pooled plasma of adult donors. Largely comprised of IgG antibodies, therapeutic immune globulin provides passive immunization by increasing the recipient's serum levels of circulating antibodies. IgG antibodies have multiple functions, including binding to and neutralizing bacterial toxins; opsonization of pathogens; activation of complement; and suppression of pathogenic cytokines and phagocytes through binding to CD5, interleukin-1a (IL-1a), interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and T-cell receptors. Therapeutic immune globulin may diminish pathogenic mechanisms in some autoimmune diseases by binding to and inhibiting the activity of autoantibodies. (NCI04)	A blood product derived from pooled IgG antibodies extracted from donor plasma delivered parenterally. It is used to treat multiple disorders, including immunodeficiencies, autoimmune disorders, and active infections.	C1909	Pharmacologic Substance			C118468	Pediatric Rheumatology Terminology		
C	C2884	Rheumatoid Arthritis	Rheumatoid Arthritis	RA	A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.	A chronic, inflammatory condition manifesting primarily as a symmetric, erosive, polyarthritis that spares the axial skeleton and is typically associated with rheumatoid factor and anti-citrullinated protein antibodies.	C2883	Arthritis			C118468	Pediatric Rheumatology Terminology		
C	C66930	Angiotensin II Receptor Antagonist	Angiotensin II Receptor Antagonist	ARB	A class of agents that act by selectively inhibiting angiotensin II receptor activation in the renin-angiotensin-aldosterone system. Angiotensin II receptor antagonists bind to and block the activation of angiotensin II type 1 (AT1) receptors, thereby reducing production and secretion of aldosterone, amongst other actions. The combined effects result in reduction of blood pressure. Although this class of agents is also used in diabetic nephropathy (kidney damage due to diabetes) and congestive heart failure, it is primarily used for the treatment of hypertension in cases where the patient is intolerant of ACE inhibitor therapy.	A pharmaceutical agent that selectively inhibits angiotensin II receptor activation in the renin-angiotensin-aldosterone system reducing production and secretion of aldosterone, amongst other actions. The combined effects result in reduction of blood pressure. It is primarily used for the reduction of proteinuria and the treatment of hypertension in cases where the patient is intolerant of ACE inhibitor therapy.	C1909	Pharmacologic Substance			C118468	Pediatric Rheumatology Terminology		
D	C29505	Topical Corticosteroid	Topical Corticosteroid		Any synthetic steroid derivative exhibiting the same function as the naturally occurring corticosteroid hormone, formulated for topical application. Topical corticosteroids are applied to the skin where it exerts its effect, however, corticosteroids can be absorbed systemically after being applied locally. Topical corticosteroids are mainly used for the localized treatment of inflammation of the skin and help relieve symptoms such as itching, swelling and redness.	A corticosteroid formulation designed for and administered onto a dermal, ocular or mucosal surface.	C2322	Corticosteroid			C118468	Pediatric Rheumatology Terminology		
D	C80510	Steroid, Systemic	Systemic Corticosteroid	Systemic Steroid	Synthetically made hormones possessing the steroid ring system; e.g., androgens, estrogens, and adrenocortical hormones. This does not include topical or inhaled steroid therapy.	Systemically-delivered (oral, intramuscular, intravenous) corticosteroids.	C2322	Corticosteroid			C118468	Pediatric Rheumatology Terminology