A C122078 Topical Corticosteroid Therapy Topical Corticosteroid Treatment with a corticosteroid formulation designed for and administered onto a dermal, ocular or mucosal surface. Treatment with a corticosteroid formulation designed for and administered onto a dermal, ocular or mucosal surface. C121367 Localized Corticosteroid C118468 Pediatric Rheumatology Terminology A C122080 Systemic Corticosteroid Therapy Systemic Corticosteroid Treatment with corticosteroids via a delivery method that will affect the entire body (oral, intramuscular, intravenous). Treatment with corticosteroids via a delivery method that will affect the entire body (oral, intramuscular, intravenous). C15986 Drug Therapy C118468 Pediatric Rheumatology Terminology C C50464 Arthralgia Arthralgia Pain in a joint. Pain in a joint. C3303 Pain C100104 Signs or Symptoms C118468 Pediatric Rheumatology Terminology C C119048 Pain Amplification Syndrome Pain Amplification Syndrome Amplified Musculoskeletal Pain Syndrome|Chronic Widespread Pain A condition in which the nerves register normal stimuli (lack of tissue injury) as pain, resulting in feelings of intense pain with even minor sensory input. A condition in which the nerves register normal stimuli (e.g., stimuli not causing tissue injury) as pain, resulting in feelings of intense pain with even minor sensory input. C26835 Neurologic Disorder C3303 Pain C118468 Pediatric Rheumatology Terminology C C121331 Intravenous Immunoglobulin Therapy Intravenous Immunoglobulin Gamma Globulin|IVIG|Immune Globulin The administration of a blood product derived from pooled IgG antibodies extracted from donor plasma delivered intravenously. It is used to treat multiple disorders, including immunodeficiencies, autoimmune disorders, and active infections. The administration of a blood product derived from pooled IgG antibodies extracted from donor plasma delivered intravenously. It is used to treat multiple disorders, including immunodeficiencies, autoimmune disorders, and active infections. C15986 Drug Therapy C118468 Pediatric Rheumatology Terminology C C121366 Intraarticular Corticosteroid Therapy Intraarticular Corticosteroid Intra-articular Corticosteroid Treatment with a corticosteroid formulation designed for and administered into a joint space. Treatment with a corticosteroid formulation designed for and administered into a joint space. C121367 Localized Corticosteroid C118468 Pediatric Rheumatology Terminology C C121367 Localized Corticosteroid Therapy Localized Corticosteroid Treatment with a corticosteroid formulation designed for delivery locally and specified by site of administration (intraarticular, topical, or inhaled). Treatment with a corticosteroid formulation designed for delivery locally and specified by site of administration (intraarticular, topical, or inhaled). C15986 Drug Therapy C118468 Pediatric Rheumatology Terminology C C121368 Stress Dose Steroid Therapy Stress Dose Steroid The administration of corticosteroids to an individual with either a long term history of corticosteroid use, or a history of or increased risk for adrenal insufficiency during times of increased physiological stress, including surgery or serious illness. The administration of corticosteroids to an individual with either a long term history of corticosteroid use, or a history of or increased risk for adrenal insufficiency during times of increased physiological stress, including surgery or serious illness. C15986 Drug Therapy C118468 Pediatric Rheumatology Terminology C C119029 Lupus Headache Lupus Headache A severe, persistent headache that occurs in patients with systemic lupus erythematosus, and is nonresponsive to narcotic analgesia. A severe, persistent headache that occurs in patients with systemic lupus erythematosus, and is nonresponsive to narcotic analgesia. C34661 Headache C118468 Pediatric Rheumatology Terminology C C3426 Ulcer Ulcer A circumscribed inflammatory and often suppurating lesion on the skin or an internal mucous surface resulting in necrosis of tissue. A circumscribed loss of integrity of the skin or mucous membrane. C36281 Integumentary System Finding C118468 Pediatric Rheumatology Terminology C C82884 Lupus Panniculitis Lupus Panniculitis A condition primarily affecting the subcutaneous adipose tissues, showing firm nodules that often resolve with lipoatrophy. There can be overlying changes of discoid lupus erythematosus. A skin biopsy showing lobular panniculitis with typical changes of lupus is needed to rule out other causes of panniculitis, including subcutaneous panniculitis-like T-cell lymphoma. A condition primarily affecting the subcutaneous adipose tissues, showing firm nodules that often resolve with lipoatrophy. There can be overlying changes of discoid lupus erythematosus. A skin biopsy showing lobular panniculitis with typical changes of lupus is needed to rule out other causes of panniculitis, including panniculitic lymphoma. C36281 Integumentary System Finding C118468 Pediatric Rheumatology Terminology C C34984 Rheumatic Fever Rheumatic Fever ARF|Acute Rheumatic Fever An inflammatory disorder that follows infection with group A streptococcus. It affects the heart, joints, and subcutaneous tissues. It manifests with pericarditis, heart murmur, congestive heart failure, polyarthritis, subcutaneous nodules, and erythema marginatum. It is characterized by the formation of granulomatous lesions called Aschoff bodies usually in the heart tissue. An inflammatory disorder that follows infection with group A streptococcus. It may manifest with carditis, migratory polyarthritis, subcutaneous nodules, erythema marginatum, and chorea. C26726 Infectious Disorder C118468 Pediatric Rheumatology Terminology C C45161 Borrelia burgdorferi Infection Lyme Disease Borrelia burgdorferi Infection An infectious disease caused by the spirochete Borrelia burgdorferi. Early manifestations of infection may include fever, headache, fatigue, depression, and a characteristic skin rash called erythema migrans. Left untreated, late manifestations involving the joints, heart, and nervous system can occur. An infectious disease caused by the spirochete Borrelia burgdorferi. C26726 Infectious Disorder C118468 Pediatric Rheumatology Terminology C C112116 Eosinophilic Fasciitis Eosinophilic Fasciitis Shulman Syndrome Inflammation and induration of the fascia related to an accumulation of white blood cells, including eosinophils. An inflammatory disease of the fascia caused by infiltration of eosinophils, which manifests as progressive thickening of the tissues, often with accompanying erythema, pain, and induration. A classic finding is eosinophilia in the peripheral blood. C3371 Integumentary System Disorder C118468 Pediatric Rheumatology Terminology C C114347 Juvenile Spondyloarthritis Juvenile Spondyloarthritis JSpA|Juvenile Spondyloarthropathy A group of chronic, inflammatory childhood diseases characterized by arthritis and enthesitis. This disorder can affect the axial skeleton in late childhood or young adulthood. Onset of spondyloarthritis before 18 years of age, and less commonly associated with axial disease. Encompasses the juvenile idiopathic arthritis categories of enthesitis-related arthritis and psoriatic arthritis, and includes many cases of undifferentiated arthritis. C2889 Autoimmune Disease C118468 Pediatric Rheumatology Terminology C C114354 Drug Induced Lupus Erythematosus Drug Induced Lupus Erythematosus Drug Induced Lupus An autoimmune disorder, similar to systemic lupus erythematosus, that is caused by certain drugs. A lupus-like condition which occurs after exposure to a specific pharmacologic agent and typically resolves after discontinuation of the agent. C3507 Immune System Disorder C118468 Pediatric Rheumatology Terminology C C114357 Juvenile Idiopathic Arthritis Juvenile Idiopathic Arthritis JIA A group of chronic, inflammatory childhood disorders of unknown etiology that primarily involve joints. An umbrella term for arthritis of unknown etiology that begins before the sixteenth birthday, and persists for at least six weeks; other known conditions are excluded. Categories include: systemic, oligoarticular, polyarticular rheumatoid factor positive, polyarticular rheumatoid factor negative, psoriatic, enthesitis-related, or undifferentiated. C2889 Autoimmune Disease C118468 Pediatric Rheumatology Terminology C C114471 Macrophage Activation Syndrome Macrophage Activation Syndrome MAS|Reactive Hemophagocytic Lymphohistiocytosis A complication of rheumatic disease that is caused by excessive activation and uncontrolled proliferation of T lymphocytes and well-differentiated macrophages. It is characterized by fever, pancytopenia, liver insufficiency, coagulopathy and neurologic symptoms. A potentially fatal complication of rheumatic disease characterized by fever, pancytopenia, hemophagocytosis, hyperferritinemia, liver insufficiency, coagulopathy and neurologic symptoms. C3507 Immune System Disorder C118468 Pediatric Rheumatology Terminology C C118240 Periodic Fever Syndrome Periodic Fever Syndrome Fevers of unknown etiology recurring over months or years. An umbrella term for disorders characterized by persistent, episodic fevers with variable clinical manifestations. They do not have an infectious etiology and lack autoantibodies or autoreactive T cells. Some are autoinflammatory in origin. C9229 Systemic Disorder C118468 Pediatric Rheumatology Terminology C C27576 Childhood Dermatomyositis Juvenile Dermatomyositis Childhood Dermatomyositis|JDM An inflammatory myopathy of childhood resulting in muscle weakness, and associated with a characteristic skin rash. An inflammatory myopathy of childhood resulting in symmetric proximal muscle weakness, and associated with characteristic cutaneous findings, such as heliotrope rash or Gottron's papules. C2889 Autoimmune Disease C118468 Pediatric Rheumatology Terminology C C2883 Arthritis Arthritis An inflammatory process affecting a joint. Causes include infection, autoimmune processes, degenerative processes, and trauma. Signs and symptoms may include swelling around the affected joint and pain. Inflammation of the joint tissues of any etiology. Signs and symptoms may include pain, swelling, warmth, guarding, limited range of motion or overlying erythema. C107377 Musculoskeletal System Disorder C118468 Pediatric Rheumatology Terminology C C34915 Pericarditis Pericarditis An inflammatory process affecting the pericardium. Inflammation of the pericardium, frequently manifested as chest pain, friction rub, pericardial effusion, or ST segment elevation on EKG. C101327 Pericardial Anomaly C118468 Pediatric Rheumatology Terminology C C34963 Henoch-Schonlein Purpura Henoch-Schonlein Purpura HSP A systemic, usually self-limited immune complex vasculitis, characterized by immunoglobulin A deposition in the small vessels and kidneys. It is manifested with small hemorrhages in the skin, gastrointestinal symptoms, arthritis, and nephropathy. A systemic, usually self-limited immune complex vasculitis, characterized by immunoglobulin A deposition in the small vessels and kidneys. It is manifested with small hemorrhages in the skin, gastrointestinal symptoms, arthritis, and nephropathy. C2931 Cardiovascular Disorder C118468 Pediatric Rheumatology Terminology C C35109 Anterior Uveitis Anterior Uveitis Inflammation of the iris and anterior chamber of the eye. Inflammation of the anterior uveal tract. Also referred to as iritis, or iridocyclitis when the ciliary body is also involved. C26909 Uveitis C118468 Pediatric Rheumatology Terminology C C35111 Posterior Uveitis Posterior Uveitis An inflammatory process that affects the choroid. Inflammation of the posterior uveal tract, also known as the choroid. Posterior uveitis may encompass vitritis, intermediate uveitis, pars planitis, choroiditis, retinitis, chorioretinitis, and retinochondritis. C26909 Uveitis C118468 Pediatric Rheumatology Terminology C C38012 Proteinuria Proteinuria The presence of excessive protein, chiefly albumin but also globulin, in the urine. The presence of excessive protein in the urine. C36292 Laboratory Test Result C118468 Pediatric Rheumatology Terminology C C72069 Localized Scleroderma Localized Scleroderma Morphea A chronic disorder, possibly autoimmune, marked by excessive production of collagen which results in hardening and thickening of body tissues. Localized scleroderma typically affects the skin, with formation of patches or lines of thick and unyielding tissue; there can be muscle and underlying tissue involvement as well as occasional joint complications. The affected areas of skin can be restrictive and disfiguring. The shape, depth and location of the affected area is used to classify one of the four types of local scleroderma. An individual can have a combination of localized scleroderma types. An autoimmune disorder marked by excessive production of collagen resulting in hardening and thickening of skin, with formation of patches or lines of thick and unyielding tissue. There can also be musculoskeletal and underlying tissue involvement. The affected areas of skin can be restrictive and disfiguring. C26746 Scleroderma C118468 Pediatric Rheumatology Terminology C C99236 Neonatal Lupus Erythematosus Neonatal Lupus Erythematosus A self-limited skin rash that appears in the neonatal period and usually resolves in four to six months after birth. It is caused by placental transfer of maternal autoantibodies, usually anti-Ro antibody. In a minority of cases, it is associated with congenital heart block, hepatitis, or thrombocytopenia. The mothers of the affected babies may be asymptomatic or suffer from systemic lupus erythematosus, Sjogren's syndrome, or rheumatoid arthritis. A disorder caused by placental transfer of maternal autoantibodies, usually anti-Ro (SSA) and/or anti-La (SSB), leading to fetal tissue damage associated with congenital heart block, and reversible manifestations such as skin rash, thrombocytopenia, and hepatitis. C98996 Neonatal Disorder C118468 Pediatric Rheumatology Terminology D C29505 Topical Corticosteroid Topical Corticosteroid Any synthetic steroid derivative exhibiting the same function as the naturally occurring corticosteroid hormone, formulated for topical application. Topical corticosteroids are applied to the skin where it exerts its effect, however, corticosteroids can be absorbed systemically after being applied locally. Topical corticosteroids are mainly used for the localized treatment of inflammation of the skin and help relieve symptoms such as itching, swelling and redness. A corticosteroid formulation designed for and administered onto a dermal, ocular or mucosal surface. C2322 Corticosteroid C118468 Pediatric Rheumatology Terminology D C80510 Steroid, Systemic Systemic Corticosteroid Systemic Steroid Synthetically made hormones possessing the steroid ring system; e.g., androgens, estrogens, and adrenocortical hormones. This does not include topical or inhaled steroid therapy. Systemically-delivered (oral, intramuscular, intravenous) corticosteroids. C2322 Corticosteroid C118468 Pediatric Rheumatology Terminology