NCIt Code NCIt PT Subset PT Subset SY NCIt Definition Subset Definition NCIt Code of First Parent First Parent NCIt Code of Second Parent Second Parent NCIt Code of Subset PT of NICHD Subset Subset Antiquated PT Subset Antiquated SY C35550 Acute Poliomyelitis Acute Poliomyelitis Polio|Poliomyelitis An acute infectious disorder that affects the nervous system. It is caused by the poliovirus. The virus spreads by direct contact, and can be prevented by prophylaxis with the polio vaccine. Inflammation of the spinal cord that is caused by the poliovirus, and that often results in flaccid paralysis. C96411 Pediatric Viral Infection C96388 Pediatric Immunization Terminology C62651 Allergen Allergen A substance that elicits an allergic reaction. C45306 Substance C96388 Pediatric Immunization Terminology C114476 Allergic Reaction Allergic Reaction An immune response that occurs following re-exposure to an innocuous antigen, and that requires the presence of existing antibodies against that antigen. This response involves the binding of IgE to mast cells, and may worsen with repeated exposures. A hypersensitivity reaction triggered by exposure to a previously encountered foreign substance to which the individual has formed antibodies. C3507 Immune System Disorder C96388 Pediatric Immunization Terminology C62761 Attenuated Bacteria Vaccine Attenuated Bacteria Vaccine Attenuated Live Bacterial Vaccine Any vaccine created by reducing the virulence of bacteria but still keeping the bacteria viable (live). In the production of an attenuated vaccine, the infectious agent is altered so that it becomes harmless or less virulent. This is in contrast to those vaccines produced by "killing" the pathogen (inactivated vaccine). C97116 Attenuated Live Vaccine C96388 Pediatric Immunization Terminology C97116 Attenuated Live Vaccine Attenuated Live Vaccine Any vaccine created by reducing the virulence of the infectious agent but still keeping the agent viable (live). In the production of an attenuated vaccine, the infectious agent is altered so that it becomes harmless or less virulent. This is in contrast to those vaccines produced by killing the pathogen (inactivated vaccine). C923 Vaccine C96388 Pediatric Immunization Terminology C1920 Attenuated Live Virus Vaccine Attenuated Live Virus Vaccine Live vaccines prepared from microorganisms which have undergone physical adaptation (e.g., by radiation or temperature conditioning) or serial passage in laboratory animal hosts or infected tissue/cell cultures, in order to produce avirulent mutant strains capable of inducing protective immunity. Live-attenuated vaccines are used when a CD8+ T Cell (cellular cytotoxicity) response is desired. C97116 Attenuated Live Vaccine C96388 Pediatric Immunization Terminology C2890 Bacterial Infection Bacterial Infection Bacterial Disease An acute infectious disorder that is caused by gram positive or gram negative bacteria; representative examples include pneumococcal, streptococcal, salmonella, and meningeal infections. An infection caused by a bacterium. C128320 Infection C96388 Pediatric Immunization Terminology C76205 Bordetella pertussis Bordetella pertussis A species of bacteria within the phylum Proteobacteria consisting of gram-negative aerobic coccobacillus that are the causative agent of pertussis. C14187 Bacteria C96388 Pediatric Immunization Terminology C9039 Cervical Carcinoma Cervical Carcinoma A carcinoma arising from either the exocervical squamous epithelium or the endocervical glandular epithelium. The major histologic types of cervical carcinoma are: squamous carcinoma, adenocarcinoma, adenosquamous carcinoma, adenoid cystic carcinoma and undifferentiated carcinoma. C9305 Cancer C96388 Pediatric Immunization Terminology C3782 Cervical Intraepithelial Neoplasia Cervical Intraepithelial Neoplasia Squamous or glandular intraepithelial neoplasia that affects the cervical mucosal epithelium. There is no evidence of stromal invasion. According to the degree of cellular atypia and the associated architectural changes, it is classified as low or high grade. C3262 Neoplasm C96388 Pediatric Immunization Terminology C97132 Chicken Pox Varicella Chickenpox A contagious childhood disorder caused by the varicella zoster virus. It is transmitted via respiratory secretions and contact with chickenpox blister contents. It presents with a vesicular skin rash, usually associated with fever, headache, and myalgias. The pruritic fluid-filled vesicles occur 10-21 days after exposure and last for 3-4 days. An additional 3-4 days of malaise follows before the affected individual feels better. An individual is contagious 1-2 days prior to the appearance of the blisters until all blisters are crusted over. Generally, healthy individuals recover without complications. Varicella zoster virus that is transmitted via respiratory secretions and vesicular skin lesions; clinical manifestations are fever and pruritic, vesicular skin rash ten to twenty-one days after exposure. Clinical complications (e.g., lung, liver and CNS) can occur, especially in immunocompromised individuals. C96411 Pediatric Viral Infection C96407 Varicella Zoster Infection C96388 Pediatric Immunization Terminology C2960 Condyloma Acuminatum Condyloma Acuminatum Condyloma Acuminata|Genital Wart|Genital Warts A sexually transmitted papillary growth caused by the human papillomavirus. It usually arises in the skin and mucous membranes of the perianal region and external genitalia. A wart of the perianal region or genitalia that is caused by sexual transmission of the human papillomavirus. C3439 Viral Infection C96388 Pediatric Immunization Terminology C37928 Confusion Confusion Disorientation A mental state characterized by a lack of clear and orderly thought and behavior. Impaired orientation to person, place or time. C87124 Central Nervous System Signs and Symptoms C96388 Pediatric Immunization Terminology C1455 Conjugate Vaccine Conjugate Vaccine A category of vaccines created by covalently attaching an antigen from an organism to a carrier protein from the same organism to aid in the delivery of the immunogen. C97125 Polysaccharide Vaccine C96388 Pediatric Immunization Terminology C3724 Cystic Hygroma Cystic Hygroma Cystic Lymphangioma A benign lymphatic neoplasm usually arising from the neck and characterized by cystic dilation of the lymphatic vessels. C2978 Cyst C3262 Neoplasm C96388 Pediatric Immunization Terminology C27644 Deafness Deafness An inherited or acquired condition characterized by the inability to hear in one or both ears. Inability to hear. C35731 Hearing Loss C96388 Pediatric Immunization Terminology C9011 Dermoid Cyst Dermoid Cyst Subcutaneous Cystic Teratoma A mature teratoma characterized by the presence of a cyst which is lined by mature tissue resembling the epidermis and the epidermal appendages. It occurs in the ovary, testis, and extragonadal sites including central nervous system and skin. A benign hamartomatous tumor that possesses various epidermal derivatives and is due to sequestration of skin along the lines of embryonic closure. In neonates, it is most commonly congenital and located in the subcutaneous tissues of the head, neck, or trunk. C2978 Cyst C96388 Pediatric Immunization Terminology C2987 Diarrhea Diarrhea Frequent Stools|Loose Stools Watery bowel movements. Watery bowel movements. C3368 Gastrointestinal System Signs and Symptoms C96388 Pediatric Immunization Terminology C34541 Diphtheria Diphtheria A Gram-positive bacterial infection caused by Corynebacterium diphtheriae. It usually involves the oral cavity, pharynx, and nasal cavity. Patients develop pseudomembranes in the affected areas and manifest signs and symptoms of an upper respiratory infection. The diphtheria toxin may cause myocarditis, polyneuritis, and other systemic effects. A toxicoinfection that is caused by Corynebacterium diphtheriae; it predominantly involves the upper respiratory tract, where pseudomembranes are characteristic. Cutaneous diphtheria, toxic myocardiopathy, and toxic neuropathy also can occur. C2890 Bacterial Infection C96388 Pediatric Immunization Terminology C91718 Diphtheria Toxoid/Tetanus Toxoid Vaccine Adsorbed Diphtheria Toxoid/Tetanus Toxoid Vaccine Adsorbed DT|Diphtheria Toxoid Tetanus Toxoid Vaccine Adsorbed A vaccine containing detoxified tetanus toxoid and detoxified diphtheria toxoid adsorbed on aluminum phosphate with active immunizing activity against diphtheria and tetanus. Intramuscular injection with this vaccine activates the immune system to develop antibodies against tetanus toxin and diphtheria toxin. C96398 Toxoid Vaccine C96388 Pediatric Immunization Terminology C91717 Diphtheria Toxoid/Tetanus Toxoid/Acellular Pertussis Vaccine Adsorbed Diphtheria Toxoid/Tetanus Toxoid/Acellular Pertussis Vaccine DTaP|Diphtheria Toxoid Tetanus Toxoid Acellular Pertussis Vaccine Adsorbed A vaccine containing detoxified tetanus toxoid, detoxified diphtheria toxoid and acellular pertussis antigens, adsorbed on aluminum phosphate, with active immunizing activity against diphtheria, tetanus and pertussis. The acellular pertussis vaccine components, produced by Bordetella pertussis, are detoxified pertussis toxin (PT), filamentous hemagglutinin (FHA), pertactin (PRN) and fimbriae types 2 and 3 (FIM). Intramuscular injection with this vaccine activates the immune system to develop antibodies against tetanus toxin, diphtheria toxin and B. pertussis antigens. C2848 Polyvalent Vaccine C96388 Pediatric Immunization Terminology C97122 Diphtheria Toxoid/Tetanus Toxoid/Inactivated Pertussis Vaccine Diphtheria Toxoid/Tetanus Toxoid/Inactivated Pertussis Vaccine DTP DTP A vaccine containing detoxified tetanus toxoid, detoxified diphtheria toxoid and inactivated pertussis antigens. C2848 Polyvalent Vaccine C96388 Pediatric Immunization Terminology C26901 Erythema Erythema Redness Red discoloration of the skin caused by infectious agents, inflammation, drug hypersensitivity, or underlying disease. Red discoloration of the skin caused by infectious agents, inflammation, drug hypersensitivity, or underlying disease. C100104 Sign or Symptom C96388 Pediatric Immunization Terminology C3038 Fever Fever Pyrexia Elevation of body temperature above normal due to inflammatory or immune responses. Elevation of body temperature above normal due to the production of more heat than the body is able to dissipate. C50589 Hyperthermia C96388 Pediatric Immunization Terminology C80444 H1N1 Influenza H1N1 Influenza Swine flu An acute viral respiratory infection caused by a strain of influenza virus which is endemic in swine (pigs). Rarely reported in humans prior to 2009, the disease is caused by a mutated strain of swine influenza A (H1N1) virus. It is highly contagious and spreads mainly through coughing and sneezing. Signs and symptoms include fever, chills, coughing, sore throat headache, muscle ache, and generalized weakness. Antiviral medications are most effective in the first two days of the illness. C53482 Influenza C96388 Pediatric Immunization Terminology C1126 Haemophilus Influenzae B Vaccine Haemophilus Influenzae B Vaccine Hib Vaccine|PRP vaccine A vaccine against serotype b of the Gram-negative bacterium H. influenzae (Hib). Hib vaccines contain polysaccharide-protein conjugate antigens that produce greater host immune responses than first-generation purified polysaccharide vaccine. These vaccines may differ with regard to use of protein carriers, polysaccharides, diluents, and preservatives. C1455 Conjugate Vaccine C96388 Pediatric Immunization Terminology C3096 Hepatitis A Infection Hepatitis A Infection Hepatitis A Acute inflammation of the liver caused by the hepatitis A virus. It is highly contagious and usually contracted through close contact with an infected individual or their feces, contaminated food or water. C3439 Viral Infection C96388 Pediatric Immunization Terminology C29090 Hepatitis A Vaccine Hepatitis A Vaccine An inactivated virus vaccine that provides active immunization against hepatitis A virus (HAV). Immunization with hepatitis A vaccine induces the formation of anti-HAV antibodies which provide protection against hepatitis A infection. C29694 Inactivated Vaccine C96388 Pediatric Immunization Terminology C3097 Hepatitis B Infection Hepatitis B Infection Hepatitis B A viral infection caused by the hepatitis B virus. C3439 Viral Infection C96388 Pediatric Immunization Terminology C29091 Hepatitis B Vaccine Hepatitis B Vaccine Recombinant Hepatitis B Vaccine A non-infectious mixture containing recombinant hepatitis B surface antigen (HBsAg) in a liquid vehicle. Immunization with the hepatitis B vaccine induces the formation of specific anti-hepatitis B antibodies and an active immunity against hepatitis B infection. C1572 Recombinant Viral Vaccine C96388 Pediatric Immunization Terminology C1951 Human Papilloma Virus Vaccine Human Papilloma Virus Vaccine HPV|Recombinant Human Papilloma Virus Vaccine A recombinant vaccine of different types of HPV proteins which are well-conserved within types with a significant inter-type variation. C1572 Recombinant Viral Vaccine C96388 Pediatric Immunization Terminology C14226 Human Papillomavirus Human Papillomavirus Human Papilloma Virus A strain of papillomavirus that can infect the skin and mucous membranes of humans. C14283 Virus C96388 Pediatric Immunization Terminology C14338 Human Papillomavirus Type 16 Human Papillomavirus-16 HPV-16 A virus comprised of a protein coat (capsid) surrounding a circular, double-stranded DNA organized into coding and non-coding regions, which can induce skin and mucosal epithelial lesions. Human papillomavirus-16 (HPV16) has been directly linked to cervical cancer and is significantly associated with invasiveness. Progression from low- to high-grade neoplasia is often associated with the integration of the HPV16 genome into the host chromosome. C14226 Human Papillomavirus C96388 Pediatric Immunization Terminology C14377 Human Papillomavirus Type 18 Human Papillomavirus-18 HPV-18 A virus comprised of a protein coat (capsid) surrounding a circular, double-stranded DNA organized into coding and non-coding regions, which can induce skin and mucosal epithelial lesions. Human papillomavirus-18 (HPV18) has been directly linked to cervical cancer and plays a role in the pathogenesis of the disease. The virus integrates its DNA at specific chromosomal locations, such as 8q24 and 12q15. The use of molecular markers for HPV18 infection may allow the identification of patients with early stage cervical cancer and those at high risk for disease recurrence. C14226 Human Papillomavirus C96388 Pediatric Immunization Terminology C15258 Immunization Immunization Inoculating an individual with either killed or live agents to prevent contraction of a disease. C25218 Intervention or Procedure C96388 Pediatric Immunization Terminology C91715 Inactivated Poliovirus Vaccine Inactivated Poliovirus Vaccine IPV A vaccine consisting of inactivated poliovirus (IPV) types 1,2 and 3, with active immunizing activity against poliomyelitis. Upon intramuscular vaccination, inactivated poliovirus vaccine (IPV) activates the immune system to develop antibodies against polioviruses. C29694 Inactivated Vaccine C96388 Pediatric Immunization Terminology C29694 Inactivated Vaccine Inactivated Vaccine A preparation of killed microorganisms that is intended to prevent or treat an infectious disease by inducing active immunity to the causative microorganism. C923 Vaccine C96388 Pediatric Immunization Terminology C26726 Infectious Disorder Infectious Disorder Clinical Infection|ID|Infectious Disease A disorder resulting from the presence and activity of a microbial, viral, fungal, or parasitic agent. It can be transmitted by direct or indirect contact. A disorder resulting from the presence and activity of a microbial, viral, fungal, or parasitic agent. It can be transmitted by direct or indirect contact. C2991 Disease or Disorder C96388 Pediatric Immunization Terminology C53482 Influenza Influenza Flu An acute viral infection of the respiratory tract, occurring in isolated cases, in epidemics, or in pandemics; it is caused by serologically different strains of viruses (influenzaviruses) designated A, B, and C, has a 3-day incubation period, and usually lasts for 3 to 10 days. It is marked by inflammation of the nasal mucosa, pharynx, and conjunctiva; headache; myalgia; often fever, chills, and prostration; and occasionally involvement of the myocardium or central nervous system. An acute viral infection of the respiratory tract, occurring in isolated cases, in epidemics, or in pandemics; it is caused by serologically different strains of viruses (influenzaviruses) designated A, B, and C, has a 3-day incubation period, and usually lasts for 3 to 10 days. It is marked by inflammation of the nasal mucosa, pharynx, and conjunctiva; headache; myalgia; often fever, chills, and prostration; and occasionally involvement of the myocardium or central nervous system. C3439 Viral Infection C96388 Pediatric Immunization Terminology C96408 Influenza Vaccination Influenza Vaccination The administration of live or attenuated influenza virus for the prophylaxis of influenza. C15258 Immunization C96388 Pediatric Immunization Terminology C96402 Live Attenuated Influenza Vaccine Live Attenuated Influenza Vaccine LAIV|Nasal Spray Flu Vaccine A vaccine that contains live attenuated influenza virus (LAIV) particles. This vaccine is administered intranasally for influenza prophylaxis. Not all populations are good candidates for LAIV; the very young, elderly, asthmatics and those with health impaired may be better treated with the trivalent inactivated vaccine that is administered intramuscularly. C1920 Attenuated Live Virus Vaccine C96388 Pediatric Immunization Terminology C34797 Malaria Malaria A protozoan infection caused by the genus Plasmodium. There are four species of Plasmodium that can infect humans: Plasmodium falciparum, vivax, ovale, and malariae. It is transmitted to humans by infected mosquitoes. Signs and symptoms include paroxysmal high fever, sweating, chills, and anemia. Plasmodium parasite infection, characterized by fever, flu-like symptoms, anemia, and jaundice, that may be transmitted through infected mosquito bites, blood transfusion, organ transplant, contaminated needles or syringes, or before or during birth. C34953 Protozoal Infection C96388 Pediatric Immunization Terminology C96406 Measles Measles Rubeola Infection|Rubeola A highly contagious viral infection caused by the measles virus. Symptoms appear 8-12 days after exposure and include a rash, cough, fever and muscle pains that can last 4-7 days. Measles vaccines are available to provide prophylaxis, usually combined with mumps and rubella vaccines (MMR). A highly contagious infection that is caused by Rubeola (measles virus). Symptoms include coryza and fever followed by a descending, coalescing macular or maculopapular rash. C96411 Pediatric Viral Infection C96388 Pediatric Immunization Terminology C96403 Measles/Mumps/Rubella Vaccine Measles/Mumps/Rubella Vaccine MMR|Measles Mumps Rubella Vaccine A trivalent vaccine containing live attenuated viruses that can cause measles, mumps and rubella. It is an injection administered subcutaneously in two separate doses. C1920 Attenuated Live Virus Vaccine C96388 Pediatric Immunization Terminology C26828 Meningitis Meningitis A disorder characterized by acute inflammation of the meninges of the brain and/or spinal cord. Inflammation of the membranes surrounding the brain and spinal cord. C27582 Central Nervous System Infectious Disease C96388 Pediatric Immunization Terminology C96391 Meningococcal Conjugate Vaccine MCV4 Meningococcal Conjugate Vaccine MCV4 MCV4|Meningococcal Conjugate Vaccine MCV-4 A conjugate vaccine of meningococcal polysaccharide used for active immunization against invasive meningococcal disease caused by Neisseria meningiditis serogroups A, C, Y, and W-135. C1455 Conjugate Vaccine C96388 Pediatric Immunization Terminology C96519 Meningococcal Polysaccharide Vaccine MPSV4 Meningococcal Polysaccharide Vaccine MPSV4 Meningococcal Polysaccharide Vaccine MPSV-4 A polysaccharide vaccine used to prevent contraction of meningococcal meningitis. C97125 Polysaccharide Vaccine C96388 Pediatric Immunization Terminology C84392 Mental Retardation Mental Retardation A developmental disorder characterized by less than average intelligence and significant limitations in adaptive behavior with onset before the age of 18. A condition of arrested or incomplete development of the mind, which is especially characterized by impairment of skills manifested during the developmental period, which contribute to the overall level of intelligence, i.e. cognitive, language, motor, and social abilities. C92190 Pediatric Psychiatric Disorder C96388 Pediatric Immunization Terminology C29888 Mumps Mumps Epidemic Parotitis A contagious viral infection caused by the mumps virus. Symptoms include swollen and tender parotid glands, fever, muscle aches and fatigue. Due to vaccination programs, mumps has become a rare disease. A contagious infection that is caused by the mumps virus; it is characterized by swollen and tender parotid glands. C96411 Pediatric Viral Infection C96388 Pediatric Immunization Terminology C86605 Neisseria meningitidis Neisseria meningitidis A species of aerobic, Gram-negative, diplococci shaped bacteria assigned to the phylum Proteobacteria. This species is catalase and oxidase positive, non-hemolytic, non-pigmented, does not reduce nitrate or nitrite, does not synthesize polysaccharides, grows on blood, chocolate, or Muller-Hinton agar, and produces acid from glucose and maltose but not fructose, sucrose, mannose, or lactose. N. meningitidis, known commonly as meningococcus, is the causative agent of cerebrospinal meningitis, but is also associated with other human infections, but can be commensal in the oropharynx and nasopharynx of carriers. C14187 Bacteria C96388 Pediatric Immunization Terminology C96401 Oral Polio Vaccine Oral Polio Vaccine A vaccine that contains live attenuated polio virus. It is administered orally as polio prophylaxis in many areas of the world, but not in the U.S. since 2000. C1920 Attenuated Live Virus Vaccine C96388 Pediatric Immunization Terminology C3303 Pain Pain The sensation of discomfort, distress, or agony, resulting from the stimulation of specialized nerve endings. An unpleasant sensation associated with real or perceived physical or mental trauma. C100104 Sign or Symptom C96388 Pediatric Immunization Terminology C27864 Parasitic Infection Parasitic Infection Parasitic Disease A successful invasion of a host by an organism that uses the host for food and shelter. An infection caused by a parasite. C128320 Infection C96388 Pediatric Immunization Terminology C96411 Pediatric Viral Infection Pediatric Viral Infection A viral infection that occurs during infancy, childhood or adolescence. C89328 Pediatric Disorder C3439 Viral Infection C96388 Pediatric Immunization Terminology C1909 Pharmacologic Substance Pharmacologic Substance Any natural, endogenously-derived, synthetic or semi-synthetic compound with pharmacologic activity. A pharmacologic substance has one or more specific mechanism of action(s) through which it exerts one or more effect(s) on the human or animal body. They can be used to potentially prevent, diagnose, treat or relieve symptoms of a disease. Formulation specific agents and some combination agents are also classified as pharmacologic substances. C45306 Substance C96388 Pediatric Immunization Terminology C97120 Pneumococcal 10-valent Conjugate Vaccine Pneumococcal 10-valent Conjugate Vaccine PCV 10 An active immunizing vaccine used to prevent infection by the bacterium Streptococcus pneumoniae. It is indicated for disease caused by serotypes 1, 5, 4, 6B, 7, 9V, 14, 18C, 19F, and 23F. C97123 Pneumococcal Conjugate Vaccine C96388 Pediatric Immunization Terminology C97121 Pneumococcal 13-valent Conjugate Vaccine Pneumococcal 13-valent Conjugate Vaccine PCV 13 A pneumococcal conjugate vaccine containing 13 different strains of the bacterium Streptococcus pneumoniae, used in children and studied in immunocompromised patients for the prevention of pneumococcal disease. The pneumococcal 13-valent conjugate vaccine contains capsular antigen polysaccharides derived from the S. pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F that are individually conjugated to a nontoxic diphtheria cross-reactive material (CRM) carrier protein (CRM197). Upon vaccination, pneumococcal 13-valent conjugate vaccine induces active immunization against 13 different serotypes of S. pneumoniae and protects against pneumococcal disease. C97123 Pneumococcal Conjugate Vaccine C96388 Pediatric Immunization Terminology C38141 Pneumococcal 7-Valent Conjugate Vaccine Pneumococcal 7-Valent Conjugate Vaccine PCV 7 An active immunizing agent used to prevent infection by the bacterium Streptococcus pneumoniae. Pneumococcal 7-valent conjugate vaccine consists of a solution of saccharides of the capsular antigens of Streptococcus serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F individually conjugated to diphtheria CRM 197 protein. C97123 Pneumococcal Conjugate Vaccine C96388 Pediatric Immunization Terminology C97123 Pneumococcal Conjugate Vaccine Pneumococcal Conjugate Vaccine An active immunizing vaccine used to prevent infection by the bacterium Streptococcus pneumoniae. It consists of a solution of saccharides of the capsular antigens of Streptococcus serotypes individually conjugated to proteins. C1455 Conjugate Vaccine C96388 Pediatric Immunization Terminology C1643 Pneumococcal Polyvalent Vaccine Pneumococcal Polyvalent Vaccine PCV 23|Pneumococcal 23-valent Polysaccharide Vaccine An polyvalent vaccine used to prevent infection by the bacterium Streptococcus pneumoniae. Pneumococcal polyvalent vaccine contains highly purified capsular antigens from the 23 most prevalent or invasive pneumococcal types of Streptococcus pneumoniae to ensure cross-protection. Following vaccination, protective capsular type-specific antibody levels typically develop by the third week; serotype-specific antibody levels generally decline after 5-10 years. C97125 Polysaccharide Vaccine C96388 Pediatric Immunization Terminology C3333 Pneumonia Pneumonia An acute, acute and chronic, or chronic inflammation focally or diffusely affecting the lung parenchyma, due to infections (viruses, fungi, mycoplasma, or bacteria), treatment (e.g. radiation), or exposure (inhalation) to chemicals. Symptoms include cough, shortness of breath, fevers, chills, chest pain, headache, sweating, and weakness. A condition resulting from infection in one or both lungs. C3198 Lung Disorder C96388 Pediatric Immunization Terminology C96409 Polio Vaccination Polio Vaccination The administration a series of either live or inactivated poliovirus for the prophylaxis of poliomyelitis. C15258 Immunization C96388 Pediatric Immunization Terminology C14259 Poliovirus Poliovirus An enterovirus comprised of an single-stranded positive sense RNA genome and a protein capsid. This virus is the human pathogen that causes poliomyelitis. C14283 Virus C96388 Pediatric Immunization Terminology C97125 Polysaccharide Vaccine Polysaccharide Vaccine A category of vaccines that use the extracted and purified outer polysaccharide coat of the particular bacteria. C923 Vaccine C96388 Pediatric Immunization Terminology C2848 Polyvalent Vaccine Polyvalent Vaccine A vaccine designed to elicit an immune response either to more than one infectious agent or to several different antigenic determinants of a single agent. C923 Vaccine C96388 Pediatric Immunization Terminology C1572 Recombinant Viral Vaccine Recombinant Viral Vaccine A vaccine produced from genetically engineered viral vector by introduction of foreign genetic materials to activate immune response in a host. C923 Vaccine C96388 Pediatric Immunization Terminology C92947 Rh Immune Globulin Administration Rh Immune Globulin Administration Rho(D) Immune Globulin Administration The administration of Rh Immune Globulin to a pregnant mother to ameliorate the effects of conflicting Rh factors during pregnancy. C49236 Therapeutic Procedure C96388 Pediatric Immunization Terminology C77199 Rotavirus Rotavirus A genus of double stranded RNA viruses that carry 11 unique double helix molecules of RNA that encode one or two proteins each. The RNA is surrounded by a three-layered icosahedral protein capsid. Viral particles are up to 76.5 nm in diameter and are not enveloped. C14283 Virus C96388 Pediatric Immunization Terminology C96394 Rotavirus Vaccine Rotavirus Vaccine A viral vaccine that prevents against rotavirus infection, the leading cause of severe acute gastroenteritis. C1920 Attenuated Live Virus Vaccine C96388 Pediatric Immunization Terminology C92872 Rubella Immunization Rubella Immunization The administration of a live attenuated viral vaccine to prevent rubella infection. C15258 Immunization C96388 Pediatric Immunization Terminology C85051 Rubella Infection Rubella German Measles|Rubella Infection A viral infection caused by the rubella virus. It is initially manifested with flu-like symptoms that last one or two days, followed by the development of a characteristic red rash which lasts from one to five days. The rash first appears in the neck and face. It subsequently spreads to the rest of the body. An infection that is caused by the rubella virus; it is characterized by a descending, non-coalescing macular or maculopapular rash and, generally, a mild systemic illness. C3439 Viral Infection C96388 Pediatric Immunization Terminology Three-Day Measles C39594 Skin Rash Skin Rash Rash|Skin Eruption Any change in the skin which affects its appearance or texture. A rash may be localized to one part of the body, or affect all the skin. Rashes may cause the skin to change color, itch, become warm, bumpy, dry, cracked or blistered, swell and may be painful. An eruption in the skin which affects its appearance and/or texture. C36281 Integumentary System Finding C100104 Sign or Symptom C96388 Pediatric Immunization Terminology C85185 Tetanus Tetanus A serious infectious disorder that follows wound contamination by the Gram-positive bacterium Clostridium tetani. The bacteria produce a neurotoxin called tetanospasmin, which causes muscle spasm in the jaw and other anatomic sites. A disorder that is caused by Clostridium tetani toxin, which is usually acquired from wound contamination. The neurotoxin causes muscle spasm in the jaw and other anatomic sites. C2890 Bacterial Infection C96388 Pediatric Immunization Terminology C96405 Tetanus and Diphtheria Toxoids Adsorbed Tetanus and Diphtheria Toxoids Adsorbed Td A sterile, intramuscular suspension of alum (aluminum potassium sulfate)-precipitated toxoids indicated for active immunization for the prevention of tetanus and diphtheria for use in persons 7 years of age or older. C96398 Toxoid Vaccine C96388 Pediatric Immunization Terminology C2660 Tetanus Toxoid Vaccine Tetanus Toxoid Vaccine TT A preparation of formaldehyde-deactivated toxin isolated from the bacterium Clostridium tetani. Tetanus toxoid is used for booster injection and can stimulate the production of antitoxin antibodies. This agent may be used as an adjuvant in cancer vaccines. C96398 Toxoid Vaccine C96388 Pediatric Immunization Terminology C96398 Toxoid Vaccine Toxoid Vaccine Any vaccine that contains an inactivated toxic substance used for disease prophylaxis or to vaccinate against snake bites. C923 Vaccine C96388 Pediatric Immunization Terminology C2643 Trivalent Influenza Vaccine Trivalent Influenza Vaccine Flu prevention|Flu prophylaxis|Flu shot|Flu vaccination|TIV A synthetic vaccine consisting of hemagglutinin (HA) antigens derived from three inactivated influenza viruses, two different influenza type A strains and one influenza type B strain. Trivalent influenza vaccine (TIV) is formulated annually, based on influenza strains projected to be prevalent in the upcoming flu season. Upon administration, the TIV provides active immunization against the three influenza virus strains, thereby protecting against influenza infection. A form of TIV containing higher concentrations of HA antigens may be used in older patients to elicit a more effective immune response. C2848 Polyvalent Vaccine C96388 Pediatric Immunization Terminology C97126 Ty21a Typhoid Vaccine Ty21a Typhoid Vaccine Ty21a A live attenuated bacteria oral vaccine used to prevent typhoid, which is caused by Salmonella typhi. C62761 Attenuated Bacteria Vaccine C96388 Pediatric Immunization Terminology C35089 Typhoid Fever Typhoid Fever A bacterial infectious disorder contracted by consumption of food or drink contaminated with Salmonella typhi. This disorder is common in developing countries and can be treated with antibiotics. A systemic febrile illness that is caused by infection with Salmonella Typhi or Salmonella Paratyphi. C2890 Bacterial Infection C96388 Pediatric Immunization Terminology C923 Vaccine Vaccine Preparations containing substances with antigenic properties administered to activate the immune system, thereby inducing an immune response. C307 Biologic C96388 Pediatric Immunization Terminology C71091 Varicella Zoster Virus Varicella Zoster Virus An icosahedral, enveloped virus containing a single molecule of linear double-stranded DNA of 125000 nucleotides that infects only humans. It is the causative agent of chickenpox and shingles. C14283 Virus C96388 Pediatric Immunization Terminology C92915 Varicella Zoster Virus Immunization Varicella Zoster Virus Immunization Chickenpox Immunization The administration of a live attenuated viral vaccine to prevent herpes zoster infection. C15258 Immunization C96388 Pediatric Immunization Terminology C77799 Varicella-Zoster Virus Strain Oka/Merck Live Antigen Varicella Vaccine Chickenpox Vaccine|Shingles Vaccine A sterile, lyophilized preparation of the Oka/Merck strain of the live, attenuated varicella-zoster virus (VZV), that can be used to prevent varicella, commonly known as chickenpox, or herpes zoster (HZ), commonly known as shingles. Upon reconstitution and subcutaneous vaccination with the VZV strain Oka/Merck live antigen, this vaccine induces antigen-specific T-cell and B-cell immune responses against the VZV, thereby protecting against VZV infection. C1920 Attenuated Live Virus Vaccine C96388 Pediatric Immunization Terminology C97127 Vi Capsular Polysaccharide Typhoid Vaccine Vi Capsular Polysaccharide Typhoid Vaccine Vi|ViCPS A live attenuated bacteria injectable vaccine used to prevent typhoid, which is caused by Salmonella typhi. C97125 Polysaccharide Vaccine C96388 Pediatric Immunization Terminology C3439 Viral Infection Viral Infection Viral Disease Any disease caused by a virus. Any disease caused by a virus. C128320 Infection C96388 Pediatric Immunization Terminology C3442 Vomiting Vomiting Emesis Forceful ejection of the contents of the stomach through the mouth. Expulsion of the contents of the stomach through the mouth. C100104 Sign or Symptom C96388 Pediatric Immunization Terminology C96396 Yellow Fever Vaccine Yellow Fever Vaccine A live, attenuated viral vaccine to prevent yellow fever, endemic to parts of Africa and South America. C1920 Attenuated Live Virus Vaccine C96388 Pediatric Immunization Terminology C35547 Yellow Fever Virus Infection Yellow Fever Yellow Fever Virus Infection A viral infection caused by a flavivirus called yellow fever virus. It is transmitted to humans from infected mosquitoes. The signs and symptoms range from a mild febrile illness to liver damage with jaundice and hemorrhages. An infection that is caused by the yellow fever virus, which is transmitted to humans by mosquitoes; the signs and symptoms range from a mild febrile illness to liver damage with jaundice and bleeding. C3439 Viral Infection C96388 Pediatric Immunization Terminology