C C131298 Parathyroid Hormone Resistance Parathyroid Hormone Resistance Pseudohypoparathyroidism A finding indicating decreased tissue sensitivity to parathyroid hormone. A set of disorders characterized by resistance to parathyroid hormone signaling, which results in hypocalcemia and hyperphosphatemia despite increased serum parathyroid hormone concentrations. C36285 Endocrine System Finding C118467 Pediatric Endocrine Terminology C C6041 Thyroid Gland Sarcoma Thyroid Sarcoma A malignant mesenchymal neoplasm primarily involving the thyroid gland. A malignant mesenchymal neoplasm primarily involving the thyroid gland. C3414 Thyroid Tumor C118467 Pediatric Endocrine Terminology C C7462 Corticotroph Adenoma ACTH-Producing Pituitary Adenoma An adenoma of the pituitary gland that produces corticotropin. The vast majority of cases are associated with Cushing disease. Clinical manifestations include truncal obesity with thin extremities, thinning of the skin, osteoporosis, and a tendency to bruise easily. Silent or hormonally non-functioning ACTH producing adenomas have also been described. They produce symptoms of a mass-related lesion. A non-malignant pituitary neoplasm that produces adrenocorticotropic hormone. C3329 Pituitary Gland Adenoma C118467 Pediatric Endocrine Terminology C C127194 Somatotroph/Lactotroph Adenoma Growth Hormone and Prolactin-Producing Adenoma A pituitary gland adenoma composed of acidophilic cells that produce both growth hormone and prolactin. It is characterized by the detection of growth hormone and prolactin within the same acidophilic cell, or an admixture of acidophilic and chromophobic cells that produce growth hormone and prolactin respectively. A non-malignant pituitary tumor that produces growth hormone and prolactin. C3329 Pituitary Gland Adenoma C118467 Pediatric Endocrine Terminology C C7461 Somatotroph Adenoma Growth Hormone-Producing Adenoma An adenoma of the anterior lobe of the pituitary gland that produces growth hormone. The vast majority of cases are hormonally functioning and are associated with either gigantism or acromegaly. A non-malignant pituitary tumor that produces growth hormone. C3329 Pituitary Gland Adenoma C118467 Pediatric Endocrine Terminology C C45927 Mixed Somatotroph and Lactotroph Adenoma Mixed Somatolactotrope Adenoma An infrequent pituitary gland adenoma composed of an admixture of acidophilic and chromophobic cells that produce growth hormone and prolactin respectively. Unlike mammosomatotroph adenomas, these two hormones are not localized in the same cell by immunohistochemistry. A non-malignant pituitary tumor composed of both acidophilic and chromophobic cells that produce growth hormone and prolactin, respectively. C127194 Growth Hormone and Prolactin-Producing Adenoma C118467 Pediatric Endocrine Terminology C C121721 Nonfunctional Pituitary Gland Macroadenoma Nonfunctional Pituitary Macroadenoma A pituitary gland macroadenoma not associated with a hormonal syndrome. A non-malignant pituitary tumor with diameter 10 millimeters or greater that does not secrete pituitary hormone(s). C4348 C118467 Pediatric Endocrine Terminology C C121678 Nonfunctional Pituitary Gland Microadenoma Nonfunctional Pituitary Microadenoma A pituitary gland microadenoma not associated with a hormonal syndrome. A non-malignant pituitary tumor with diameter less than 10 millimeters that does not secrete pituitary hormone(s). C4348 C118467 Pediatric Endocrine Terminology C C3342 Lactotroph Adenoma Prolactinoma An adenoma of the anterior lobe of the pituitary gland that produces prolactin. It is the most common type of pituitary gland adenomas and it is associated with hyperprolactinemia. Clinical manifestations include amenorrhea, galactorrhea, impotence, headache, and visual disturbances. A non-malignant prolactin-secreting pituitary tumor. C3329 Pituitary Gland Adenoma C118467 Pediatric Endocrine Terminology C C45928 Mammosomatotroph Adenoma Somatolactotrope Adenoma Mammosomatotrope Adenoma|Somatomammotrope Adenoma A pituitary gland adenoma composed of acidophilic cells that produce both growth hormone and prolactin. Immunohistochemical studies reveal the presence of these two hormones localized in the same cell. A non-malignant pituitary tumor composed of acidophilic cells that produce both growth hormone and prolactin. Immunohistochemical studies reveal the presence of these two hormones localized in the same cell. C127194 Growth Hormone and Prolactin-Producing Adenoma C118467 Pediatric Endocrine Terminology C C8011 Thyrotroph Adenoma Thyroid Stimulating Hormone-Producing Adenoma TSH-producing Adenoma A rare adenoma of the anterior lobe of the pituitary gland that produces thyrotropin. It is usually associated with goiter and hyperthyroidism. A benign pituitary tumor that produces thyroid-stimulating hormone. C3329 Pituitary Gland Adenoma C118467 Pediatric Endocrine Terminology C C121944 Rapid-Onset Obesity with Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation Rapid-Onset Obesity with Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation Syndrome ROHHAD A very rare disorder that appears after the first year and a half of life in previously healthy children. It is characterized by rapid-onset weight gain, hypothalamic dysfunction, breathing abnormalities, and autonomic system dysregulation. The hypothalamic dysfunction manifestations include inability to maintain normal water balance, high prolactin levels, low thyroid, low cortisol, and early or late puberty. The breathing abnormalities include sleep apnea and alveolar hypoventilation, requiring ventilation support. The autonomic system dysregulation includes eye abnormalities, intestinal abnormalities, temperature dysregulation, and low heart rhythm. This disorder requires early recognition because it may lead to cardiorespiratory arrest. Up to 40% of the patients develop tumors of neural crest origin. A syndrome of unknown etiology characterized by hypothalamic dysfunction with hyperphagia, inability to maintain normal water balance, growth hormone deficiency, hypothyroidism, early or late puberty, increased prolactin concentration, hypoventilation, and autonomic dysfunction. C28193 Syndrome C118467 Pediatric Endocrine Terminology C C35710 Triple A Syndrome Triple A Syndrome 3A syndrome|Achalasia-Addisonianism-Alacrima Syndrome|Allgrove Syndrome|Triple-A syndrome An autosomal recessive condition caused by mutation(s) in the AAAS gene encoding the protein ALADIN, and characterized by primary adrenal insufficiency, esophageal dysmotility, and absence of tear production. An autosomal recessive condition caused by mutation(s) in the AAAS gene encoding the protein ALADIN, and characterized by primary adrenal insufficiency, esophageal dysmotility, and absence of tear production. C28193 Syndrome C118467 Pediatric Endocrine Terminology