D C98131 Hypofibrinogenemia Hypofibrinogenemia Factor I Deficiency|Fibrinogen Deficiency A blood coagulation disorder characterized by low levels of fibrinogen in the blood, resulting in bleeding. Abnormally low level of fibrinogen in the blood. C36292 Laboratory Test Result C118464 Pediatric Adverse Events Terminology C C26747 Type 2 Diabetes Mellitus Type 2 Diabetes Mellitus Adult Onset Diabetes|Noninsulin Dependent Diabetes|Type 2 Diabetes A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity. Diabetes mellitus caused by decreased insulin action in target tissues and insufficient production of insulin by pancreatic beta cells. C2985 Diabetes Mellitus C118464 Pediatric Adverse Events Terminology C C2986 Type 1 Diabetes Mellitus Type 1 Diabetes Mellitus Immune Mediated Diabetes|Insulin Dependent Diabetes|Juvenile Diabetes|Type 1 Diabetes|Type I Diabetes A chronic condition characterized by minimal or absent production of insulin by the pancreas. Diabetes mellitus caused by cell-mediated autoimmune destruction of pancreatic beta cells. C2985 Diabetes Mellitus C118464 Pediatric Adverse Events Terminology C C113144 Central Hypothyroidism Central Hypothyroidism Hypothalamic-Pituitary Hypothyroidism|TSH Deficiency|Thyroid Stimulating Hormone Deficiency|Thyrotropin Deficiency Abnormally low levels of thyroid hormones due to a disorder originating within the hypothalamic-pituitary axis. Subnormal concentrations of thyroid hormone(s) caused by hypothalamic-pituitary dysfunction. C3009 Endocrine System Disorder C118464 Pediatric Adverse Events Terminology C C113347 Hypogonadotropic Hypogonadism Hypogonadotropic Hypogonadism Central Hypogonadism|Secondary Hypogonadism Abnormal ovarian or testicular function due to insufficient hormonal stimulation from the hypothalamic-pituitary axis. Hypogonadism due to an intrinsic deficiency of gonadotropin secretion. C3009 Endocrine System Disorder C118464 Pediatric Adverse Events Terminology C C98810 Ambiguous Genitalia Atypical Genitalia A rare congenital abnormality in which the infant's external genitalia do not have the typical appearance of a male's or female's genitalia. External genitalia that are neither typically male nor typically female in appearance. C103185 Congenital Reproductive System Abnormality C118464 Pediatric Adverse Events Terminology C C26692 Factor I Deficiency Factor I Deficiency Fibrinogen Deficiency|Hypofibrinogenemia A usually inherited blood coagulation disorder characterized by the partial or complete absence of fibrinogen in the blood, resulting in bleeding. A coagulation disorder characterized by the partial or complete absence of fibrinogen (factor I) activity in the blood. C27215 Coagulation Factor Deficiency C36292 Laboratory Test Result C118464 Pediatric Adverse Events Terminology C C99110 Drug Induced Thrombocytopenia Drug-Induced Thrombocytopenia Drug Induced Thrombocytopenia|Drug-Induced Immune Thrombocytopenia Thrombocytopenia caused by ingested or injected drugs. It may be the result of decreased platelet production due to bone marrow suppression or increased rate of platelet destruction. Thrombocytopenia caused by medications, which can be the result of decreased platelet production due to bone marrow suppression or increased rate of platelet destruction. C131634 Platelet Abnormality C3408 Thrombocytopenia C118464 Pediatric Adverse Events Terminology C C3017 Ependymoma Ependymoma A WHO grade II, slow growing tumor of children and young adults, usually located intraventricularly. It is the most common ependymal neoplasm. It often causes clinical symptoms by blocking cerebrospinal fluid pathways. Key histological features include perivascular pseudorosettes and ependymal rosettes. (WHO) A malignant neoplasm arising from ependymal cells that line the ventricles of the brain and the central canal of the spinal cord. C3268 Nervous System Neoplasm C118464 Pediatric Adverse Events Terminology C C60781 Astrocytoma Astrocytoma A tumor of the brain or spinal cord showing astrocytic differentiation. It includes the following clinicopathological entities: pilocytic astrocytoma, diffuse astrocytoma, anaplastic astrocytoma, pleomorphic xanthoastrocytoma, and subependymal giant cell astrocytoma. A malignant neoplasm of the central nervous system that arises from astrocytes. C3268 Nervous System Neoplasm C118464 Pediatric Adverse Events Terminology C C2992 Disseminated Intravascular Coagulation Disseminated Intravascular Coagulation DIC A pathological process where the blood starts to coagulate throughout the whole body. This depletes the body of its platelets and coagulation factors, and there is an increased risk of hemorrhage. Excessive activation of the body's coagulation system resulting in systemic microvascular thrombi formation. C2902 Coagulation Disorder C131658 Consumptive Coagulopathy C118464 Pediatric Adverse Events Terminology C C99111 Heparin Induced Thrombocytopenia Heparin-Induced Thrombocytopenia HIT|Heparin Induced Thrombocytopenia A life-threatening complication of heparin therapy. It results in immune-mediated thrombocytopenia and, in 25-50 percent of the patients, thrombotic complications. A complication of heparin therapy. It results in immune-mediated thrombocytopenia and, in 25-50 percent of the patients, thrombotic complications. C99110 Drug-Induced Thrombocytopenia C3991 Immune Thrombocytopenia C118464 Pediatric Adverse Events Terminology C C3446 Idiopathic Thrombocytopenic Purpura Immune Thrombocytopenic Purpura ITP|Idiopathic Thrombocytopenic Purpura An autoimmune disorder in which the number of circulating platelets is reduced due to their antibody-mediated destruction. ITP is a diagnosis of exclusion and is heterogeneous in origin. Disorder characterized by abnormally low level of circulating platelets, usually with normal hemoglobin/red blood cell and white blood cell levels, and thought to be secondary to autoimmune destruction. C3408 Thrombocytopenia C3991 Immune Thrombocytopenia C118464 Pediatric Adverse Events Terminology C C78797 Thrombotic Thrombocytopenic Purpura Thrombotic Thrombocytopenic Purpura TTP A coagulation disorder characterized by extensive formation of thrombi in small blood vessels throughout the body due to low levels of ADAMTS13 protein, and resulting in consumption of circulating platelets, which is characterized by thrombocytopenia, anemia, neurologic changes, and sometimes fever and renal dysfunction. A coagulation disorder characterized by extensive formation of thrombi in small blood vessels throughout the body due to low levels of ADAMTS13 protein, and resulting in consumption of circulating platelets, which is characterized by thrombocytopenia, anemia, neurologic changes, and sometimes fever and renal dysfunction. C78787 Purpura C3991 Immune Thrombocytopenia C118464 Pediatric Adverse Events Terminology C C34382 Megaloblastic Anemia Megaloblastic Anemia Anemia characterized by the presence of unusually large erythroblasts in the bone marrow called megaloblasts. It is usually caused by vitamin B12 or folic acid deficiency. Other causes include toxins and drugs. A disorder characterized by low red blood cells and/or hemoglobin and abnormally large, immature circulating red blood cells. C2869 Anemia C34381 Macrocytic Anemia C118464 Pediatric Adverse Events Terminology C C3728 Hepatoblastoma Hepatoblastoma A malignant liver neoplasm that occurs almost exclusively in infants, although isolated cases in older children and adults have been reported. Grossly, hepatoblastoma is solid, well circumscribed, and more often solitary than multiple. Microscopically, most of the tumors are composed exclusively of immature hepatocytic elements. About a fourth of hepatoblastomas contain a stromal component that may be undifferentiated or develop into bone or cartilage. The treatment of choice for hepatoblastoma is surgical excision with adjuvant therapy. Liver transplantation is being increasingly used as well. A malignant liver tumor that arises from precursors of hepatocytes. It occurs almost exclusively in infants. The lungs are the most common site of metastasis. C34803 Primary Malignant Liver Neoplasm C118464 Pediatric Adverse Events Terminology C C3222 Medulloblastoma Medulloblastoma A malignant, invasive embryonal neoplasm arising from the cerebellum. It occurs predominantly in children and has the tendency to metastasize via the cerebrospinal fluid pathways. Signs and symptoms include truncal ataxia, disturbed gait, lethargy, headache, and vomiting. There are four histologic variants: classic medulloblastoma, large cell/anaplastic medulloblastoma, desmoplastic/nodular medulloblastoma, and medulloblastoma with extensive nodularity. A rapidly progressive cancer of the brain that originates in the cerebellum. C3268 Nervous System Neoplasm C118464 Pediatric Adverse Events Terminology C C3270 Neuroblastoma Neuroblastoma A neuroblastic tumor characterized by the presence of neuroblastic cells, the absence of ganglion cells, and the absence of a prominent Schwannian stroma formation. A malignant neoplasm comprised of neuroblasts that commonly arises in or near the adrenal glands. C3268 Nervous System Neoplasm C118464 Pediatric Adverse Events Terminology C C3359 Rhabdomyosarcoma Rhabdomyosarcoma A rare aggressive malignant mesenchymal neoplasm arising from skeletal muscle. It usually occurs in children and young adults. Only a small percentage of tumors arise in the skeletal muscle of the extremities. The majority arise in other anatomical sites. A malignant neoplasm arising from skeletal myocytes. C9306 Soft Tissue Sarcoma C118464 Pediatric Adverse Events Terminology C C3873 Ovarian Germ Cell Tumor Ovarian Germ Cell Tumor A neoplasm that arises from the ovary and originates from germ cells. Representative examples include teratoma, embryonal carcinoma, yolk sac tumor, and dysgerminoma. A neoplasm arising from gonadal tissue within the ovary. C114801 Childhood Gonadal Germ Cell Tumor C118464 Pediatric Adverse Events Terminology C C4980 Acute Graft Versus Host Disease Acute Graft Versus Host Disease A syndrome of immunologically mediated tissue damage that may occur following an allogeneic transplant, usually affecting the skin, liver, and GI tract. The onset is usually within one hundred days of transplantation or immunologic manipulation. A complication of allogeneic bone marrow or blood cell transplantation, occurring within the first three months of transplantation, in which donor lymphoid cells damage the host tissue. C3063 Graft Versus Host Disease C118464 Pediatric Adverse Events Terminology C C4981 Chronic Graft Versus Host Disease Chronic Graft Versus Host Disease A syndrome of immunologically mediated tissue damage that may occur following an allogeneic transplant, and may affect multiple organs with manifestations similar to autoimmune diseases. The onset is usually within three years of transplantation or immunologic manipulation. A complication of allogeneic bone marrow or blood cell transplantation, usually occurring more than three months after transplantation, in which donor lymphoid cells damage the host tissue. C3063 Graft Versus Host Disease C118464 Pediatric Adverse Events Terminology C C8591 Testicular Germ Cell Tumor Testicular Germ Cell Tumor A germ cell tumor arising from the testis. Representative examples include teratoma, seminoma, embryonal carcinoma, and yolk sac tumor. A neoplasm arising from gonadal tissue within the testes. C114801 Childhood Gonadal Germ Cell Tumor C118464 Pediatric Adverse Events Terminology C C84479 Thrombophilia Thrombophilia Hypercoagulability State|Hypercoagulability|Hypercoagulable A condition characterized by an abnormally high level of thrombi. Causes include thrombotic thrombocytopenic purpura, disseminated intravascular coagulation, bone marrow disorders, and antiphospholipid antibody syndrome. Abnormally increased tendency of the blood to form clots. C2902 Coagulation Disorder C118464 Pediatric Adverse Events Terminology C C114852 New Onset Diabetes After Transplant New Onset Diabetes After Transplant Development of diabetes after transplant, usually associated with calcineurin inhibitor use. Development of diabetes after transplant, usually associated with calcineurin inhibitor use. C2985 Diabetes Mellitus C118464 Pediatric Adverse Events Terminology C C113206 Hypoaldosteronemia Aldosterone Deficiency Hypoaldosteronemia|Hypoaldosteronism|Mineralocorticoid Deficiency Abnormally low levels of aldosterone in the blood. Reduced or absent secretion of mineralocorticoids, primarily aldosterone. C36292 Laboratory Test Result C118464 Pediatric Adverse Events Terminology C C113210 Cushing Disease Cushing Disease ACTH Producing Pituitary Adenoma|Cushing's Disease Cushing's syndrome due to abnormally high secretion of adrenocorticotropic hormone (ACTH) from the pituitary gland. Cushing syndrome due to an adrenocorticotropic hormone-producing adenoma in the pituitary gland. C3009 Endocrine System Disorder C118464 Pediatric Adverse Events Terminology C C113215 Androgen Excess Hyperandrogenism Androgen Excess Excessive secretion of androgens from the adrenal glands or gonads. Clinical manifestations may include virilization. Excessive secretion of androgens by the adrenal glands and/or gonads. C36285 Endocrine System Finding C118464 Pediatric Adverse Events Terminology C C113348 Hypergonadotropic Hypogonadism Hypergonadotropic Hypogonadism Primary Gonadal Failure Ovarian or testicular dysfunction associated with high levels of gonadotropins. Ovarian or testicular dysfunction that results in high concentrations of gonadotropins. C3009 Endocrine System Disorder C118464 Pediatric Adverse Events Terminology C C2969 Cushing Syndrome Cushing Syndrome Cortisol Excess|Cushing's Syndrome|Hypercortisolism A syndrome caused by high levels of cortisol in the blood either due to excessive production and secretion of corticosteroids secondary to pituitary or adrenocortical neoplasms, or intake of glucocorticoid drugs. Signs and symptoms include a round face, upper body obesity, fragile and thin skin, purple stretch marks in the skin, fatigue, muscle weakness, hypertension, diabetes mellitus, hypertrichosis and amenorrhea in women, impotence in men, and osteoporosis. A clinical condition characterized by variable degrees of central obesity, rounding of the face ("moon" face), hypertension, striae, and a number of other physical findings, as a result of prolonged exposure to supranormal cortisol concentration of any etiology. C3009 Endocrine System Disorder C118464 Pediatric Adverse Events Terminology C C4815 Thyroid Gland Carcinoma Thyroid Carcinoma Thyroid Cancer A carcinoma arising from the thyroid gland. It is usually an adenocarcinoma and includes the following main subtypes: follicular, papillary, medullary, poorly differentiated, and anaplastic. A malignant tumor arising from the epithelial cells of the thyroid gland. C9305 Cancer C118464 Pediatric Adverse Events Terminology C C110940 Panhypopituitarism Panhypopituitarism Complete Hypopituitarism Insufficient production of all the anterior pituitary hormones. A deficiency of all anterior pituitary hormones, without necessary involvement of the hormones of the posterior pituitary gland (oxytocin and vasopressin). C3009 Endocrine System Disorder C118464 Pediatric Adverse Events Terminology C C112835 Growth Hormone Deficiency Growth Hormone Deficiency GH Deficiency|Somatotropin Deficiency Insufficient production of growth hormone. Insufficient growth hormone secretion. C36285 Endocrine System Finding C118464 Pediatric Adverse Events Terminology C C113099 Pediatric Failure to Thrive Pediatric Failure to Thrive Failure to Thrive Less than normal weight gain in an infant or child, which may include poor linear and head growth. Suboptimal weight gain in an infant or child, which, if severe and/or prolonged, may lead to impaired linear and head growth. C36285 Endocrine System Finding C118464 Pediatric Adverse Events Terminology C C113147 Hashitoxicosis Hashitoxicosis Hashimoto Toxicosis Severe, transient hyperthyroidism associated with Hashimoto thyroiditis. Transient hyperthyroidism associated with Hashimoto thyroiditis. C3009 Endocrine System Disorder C118464 Pediatric Adverse Events Terminology C C113170 Sick Euthyroid Syndrome Sick Euthyroid Syndrome Euthyroid Sick Syndrome Abnormal thyroid function tests, low triiodothyronine with elevated reverse triiodothyronine, in the setting of non-thyroidal illness. A pattern of thyroid function tests associated with a non-thyroidal illness in which triiodothyronine is low while reverse triiodothyronine is elevated. C3009 Endocrine System Disorder C118464 Pediatric Adverse Events Terminology C C113171 Transient Hypothyroxinemia of Prematurity Transient Hypothyroxinemia of Prematurity Hypothyroxinemia of Prematurity|THOP|Transient Congenital Hypothyroidism A common, self-limiting thyroid disorder seen in preterm infants that is characterized by abnormally low serum levels of thyroxine and free thyroxine with normal serum levels of thyroid stimulating hormone. A congenital condition in which the function of the thyroid gland is transiently impaired, resulting in a subnormal concentration(s) of thyroid hormone(s) in the neonatal period. C3009 Endocrine System Disorder C118464 Pediatric Adverse Events Terminology C C113217 Gonadotropin-Dependent Precocious Puberty Gonadotropin-Dependent Precocious Puberty Central Precocious Puberty|Gonadotropin-releasing Hormone-dependent Precocious Puberty|True Precocious Puberty Premature onset of sexual development triggered by the premature secretion of gonadotropins. Precocious puberty due to premature activation of the hypothalamic-pituitary-gonadal axis. C36285 Endocrine System Finding C118464 Pediatric Adverse Events Terminology C C118423 Infantile Cortical Hyperostosis Infantile Cortical Hyperostosis Caffey Disease A self-limited inflammatory disorder of unknown etiology found in infants that causes swelling of the soft tissue, changes to bone, and irritability. An autosomal dominant condition caused by mutation(s) in the COL1A1 gene encoding the collagen alpha-1(I) chain. This disease is an acute inflammatory condition of infancy that causes soft tissue swelling (mostly of chin/cheeks), bone thickening/widening (particularly of the mandible/clavicles/long bones), pain, and irritability. This disease generally resolves by the 3rd year of life, although some bony deformity may persist. C89328 Pediatric Disorder C118464 Pediatric Adverse Events Terminology C C26691 Adrenocortical Insufficiency Adrenal Insufficiency Adrenal Cortical Hypofunction|Adrenocortical Insufficiency|Hypocortisolemia|Hypocortisolism An endocrine or hormonal disorder that occurs when the adrenal cortex does not produce enough of the hormone cortisol and in some cases, the hormone aldosterone. It may be due to a disorder of the adrenal cortex (Addison's disease or primary adrenal insufficiency) or to inadequate secretion of ACTH by the pituitary gland (secondary adrenal insufficiency). Subnormal concentration of cortisol, with or without mineralocorticoid insufficiency. C3009 Endocrine System Disorder C118464 Pediatric Adverse Events Terminology C C3071 Graves Disease Graves Disease Basedow Disease Hyperthyroidism associated with diffuse hyperplasia of the thyroid gland (goiter), resulting from production of antibodies that are directed against the thyrotropin receptor complex of the follicular epithelial cells. As a result, the thyroid gland enlarges and secrets increased amounts of thyroid hormones. An autoimmune condition characterized by excessive immunoglobulin stimulation of the thyroid gland resulting in hyperthyroidism. C3009 Endocrine System Disorder C118464 Pediatric Adverse Events Terminology C C3988 Syndrome of Inappropriate Antidiuretic Hormone Secretion Syndrome of Inappropriate Antidiuretic Hormone Inappropriate ADH Secretion|Inappropriate Arginine Vasopressin Secretion|SIADH|Syndrome of Inappropriate Antidiuretic Hormone Secretion|Syndrome of Inappropriate Vasopressin Secretion A syndrome characterized by abnormal secretion of antidiuretic hormone in conjunction with neoplastic growth occurring anywhere in the body. A syndrome characterized by elevated concentrations of antidiuretic hormone (ADH) or ADH-like peptides, in the setting of hyponatremia and hypoosmolality. Causes include surgical damage to the pituitary stalk, drugs that stimulate release of, or mimic ADH, including psychotropic drugs, ectopic production of ADH, and pulmonary disease. C3009 Endocrine System Disorder C118464 Pediatric Adverse Events Terminology C C50530 Diabetic Ketoacidosis Diabetic Ketoacidosis DKA The metabolic condition resulted from uncontrolled diabetes mellitus, in which the shift of acid-base status of the body toward the acid side because of loss of base or retention of acids other than carbonic acid is accompanied by the accumulation of ketone bodies in body tissues and fluids. A metabolic derangement characterized by ketosis, acidosis, and often hyperglycemia, as a consequence of absolute or relative insulin deficiency. C3235 Metabolic Disease C118464 Pediatric Adverse Events Terminology C C62602 Secondary Adrenal Insufficiency Central Adrenal Insufficiency Central Hypoadrenalism A hormonal disorder that occurs when lack of corticotropin-releasing hormone (CRH) secretion from the hypothalamus or adrenocorticotropic hormone (ACTH) secretion from the pituitary is responsible for hypofunction of the adrenal cortex. Diminished production of adrenocortical hormones due to a condition originating in the hypothalamus and/or pituitary gland. C3009 Endocrine System Disorder C118464 Pediatric Adverse Events Terminology C C84933 Neurogenic Diabetes Insipidus Central Diabetes Insipidus ADH Deficiency|AVP deficiency|Antidiuretic Hormone Deficiency|Arginine Vasopressin Deficiency|Neurogenic Diabetes Insipidus|Vasopressin Deficiency Diabetes insipidus caused by decreased secretion of antidiuretic hormone from the pituitary gland. Diabetes insipidus caused by a decrease in the secretion of antidiuretic hormone (vasopressin) from the posterior pituitary gland; causes include autoimmune and/or inflammatory conditions, congenital anomalies of the central nervous system and pituitary gland, mutation(s) of the AVP gene, irradiation to the region, neoplasia, surgery, and trauma. C43263 Diabetes Insipidus C118464 Pediatric Adverse Events Terminology C C113814 Autoimmune Primary Adrenal Insufficiency Autoimmune Adrenalitis Diminished production of adrenocortical hormones due to autoimmune destruction of the adrenal glands. Addison disease due to autoimmune destruction of the adrenal glands. C3009 Endocrine System Disorder C118464 Pediatric Adverse Events Terminology C C112834 Growth Hormone Excess Growth Hormone Excess Overproduction of growth hormone, a protein-based peptide that stimulates growth, cell reproduction, and cell regeneration. Persistently elevated serum concentration of growth hormone. C36285 Endocrine System Finding C118464 Pediatric Adverse Events Terminology C C112836 Thyroid Storm Thyroid Storm Acute onset of severe, life-threatening hyperthyroidism caused by a sudden release of excessive thyroid hormone. An acute complication of hyperthyroidism characterized by fever, tachycardia, nausea, agitation and/or coma that may result in death. C3009 Endocrine System Disorder C118464 Pediatric Adverse Events Terminology C C112840 Adrenal Crisis Adrenal Crisis A life threatening condition due to inadequate levels of glucocorticoids in an individual with adrenal insufficiency. A life threatening condition due to inadequate concentration of glucocorticoids characterized by loss of vascular tone leading to hypotension, tachycardia, and eventual cardiovascular collapse. C3009 Endocrine System Disorder C118464 Pediatric Adverse Events Terminology C C113100 Growth Failure Growth Failure Linear Growth Failure Less than normal linear growth in an infant or child. Subnormal linear growth rate in an infant, child, or adolescent based on the normative values for the age and sex of the reference population. C36285 Endocrine System Finding C118464 Pediatric Adverse Events Terminology C C113101 Insulin Resistance Insulin Resistance Decreased sensitivity to circulating insulin which may result in acanthosis nigicrans, elevated insulin level or hyperglycemia. Decreased insulin signaling such that the glycemic response to a given amount of insulin is reduced. C36285 Endocrine System Finding C118464 Pediatric Adverse Events Terminology C C113104 Hyperinsulinemia Hyperinsulinemia Abnormally high levels of insulin in the blood. Blood insulin concentrations above the reference range for age. C36292 Laboratory Test Result C118464 Pediatric Adverse Events Terminology C C113143 Primary Hypothyroidism Primary Hypothyroidism Abnormally low levels of thyroid hormones due to a disorder originating within the thyroid gland. Hypothyroidism due to dysfunction of the thyroid gland. C3009 Endocrine System Disorder C118464 Pediatric Adverse Events Terminology C C113146 Central Hyperthyroidism Central Hyperthyroidism Overproduction of thyroid hormones due to a disorder originating within the hypothalamic-pituitary axis. Hyperthyroidism due to a condition originating within the hypothalamic-pituitary axis. C3009 Endocrine System Disorder C118464 Pediatric Adverse Events Terminology C C113168 Hyperprolactinemia Hyperprolactinemia Abnormally high level of prolactin in the blood. Supranormal concentration of prolactin. C36292 Laboratory Test Result C118464 Pediatric Adverse Events Terminology C C113172 Primary Adrenal Insufficiency Primary Adrenal Insufficiency A hormonal disorder that occurs when the adrenal glands fail to release adequate amounts of glucocorticoids (cortisol), mineralocorticoids (aldosterone, 11-deoxycorticosterone), and androgens (dehydroepiandrosterone) to meet physiologic needs, despite release of ACTH from the pituitary. Adrenal insufficiency due to a condition originating within the adrenal glands. C3009 Endocrine System Disorder C118464 Pediatric Adverse Events Terminology C C113203 Adrenal Androgen Deficiency Adrenal Androgen Deficiency Adrenal Hypoandrogenism Abnormally low or absent secretion of the androgen precursor hormones dehydroepiandrosterone (DHEA), DHEA sulfate, and androstenedione, from the adrenal gland. Reduced concentrations of the adrenal androgens dehydroepiandrosterone (DHEA), DHEA sulfate, and androstenedione. C36285 Endocrine System Finding C118464 Pediatric Adverse Events Terminology C C113213 Hyperaldosteronism Hyperaldosteronism Aldosteronism Overproduction of aldosterone by the adrenal glands, which may lead to hypokalemia and/or hypernatremia. The condition that results from prolonged exposure to a supranormal concentration of aldosterone, characterized by hypertension, and may include hypokalemia. C3009 Endocrine System Disorder C36292 Laboratory Test Result C118464 Pediatric Adverse Events Terminology C C113214 Primary Hypoparathyroidism Primary Hypoparathyroidism Abnormally low levels of parathyroid hormone due to a disorder originating within the parathyroid glands. Hypoparathyroidism due to a condition originating within the parathyroid glands. C3009 Endocrine System Disorder C118464 Pediatric Adverse Events Terminology C C113219 Gonadotropin-Independent Precocious Puberty Gonadotropin-Independent Precocious Puberty Peripheral Precocious Puberty Premature development of secondary sexual characteristics due to the presence of sex steroids independent of pituitary gonadotropin release. Precocious puberty due to increased secretion of gonadal sex steroids independent of pituitary gonadotropin release. C36285 Endocrine System Finding C118464 Pediatric Adverse Events Terminology C C113335 Secondary Hyperparathyroidism Secondary Hyperparathyroidism Overproduction of parathyroid hormone in response to influence external to the parathyroid glands. Overproduction of parathyroid hormone in response to a condition originating extrinsic to the parathyroid glands. C3009 Endocrine System Disorder C118464 Pediatric Adverse Events Terminology C C113336 Pubertal Failure Pubertal Failure Abnormally absent or incomplete sexual development. Onset of pubertal development followed by failure to complete sexual maturation. C36285 Endocrine System Finding C118464 Pediatric Adverse Events Terminology C C113337 Premature Adrenarche Premature Adrenarche Premature onset of adrenal androgen-mediated secondary sexual characteristics. Premature onset of adrenal androgen secretion resulting in early development of androgen mediated secondary sexual characteristics. C36285 Endocrine System Finding C118464 Pediatric Adverse Events Terminology C C113340 Secondary Amenorrhea Secondary Amenorrhea The cessation of menstruation for six months or more in a female that is not pregnant, breastfeeding or menopausal. Amenorrhea in the setting of the following factors: occurring after the onset of menarche; persisting for six months or more; occurring in the absence of pregnancy, breastfeeding, or menopause. C3009 Endocrine System Disorder C118464 Pediatric Adverse Events Terminology C C113342 Premature Thelarche Premature Thelarche Isolated breast development prior to the normal age of pubertal onset in females. Onset of breast development before the lower limit of the normal age of onset of breast development in girls without other signs of puberty. C36285 Endocrine System Finding C118464 Pediatric Adverse Events Terminology C C113343 Galactorrhea Galactorrhea Nipple Discharge Excessive secretion of breast milk. Milky discharge from the nipple unrelated to lactation. C36285 Endocrine System Finding C118464 Pediatric Adverse Events Terminology C C114821 Tertiary Hyperparathyroidism Tertiary Hyperparathyroidism An overproduction of parathyroid hormone that is autonomous and often associated with chronic secondary hyperparathyroidism. Unregulated secretion of parathyroid hormone following prolonged secondary hyperparathyroidism. C3009 Endocrine System Disorder C118464 Pediatric Adverse Events Terminology C C26797 Hyperglycemia Hyperglycemia Elevated Blood Glucose Abnormally high level of glucose in the blood. Plasma glucose concentration above the reference range. C36292 Laboratory Test Result C118464 Pediatric Adverse Events Terminology C C26800 Hypothyroidism Hypothyroidism Abnormally low levels of thyroid hormone. Reduced secretion of thyroid hormone(s) by the thyroid gland. C3009 Endocrine System Disorder C118464 Pediatric Adverse Events Terminology C C26878 Rickets Rickets Bone softening and weakening usually caused by deficiency or impaired metabolism of vitamin D. Deficiency of calcium, magnesium, or phosphorus may also cause rickets. It predominantly affects children who suffer from severe malnutrition. It manifests with bone pain, fractures, muscle weakness, and skeletal deformities. A disorder of defective chondrocyte differentiation and mineralization of the epiphyseal plate due to deficiency of calcium, phosphate, or vitamin D. Rickets can manifest clinically with features such as craniotabes, costrochondral junction enlargement, widening of the wrists and ankles, lower extremity bowing, and failure to thrive. This condition is diagnosed radiographically, and is characterized by growth plate widening as well as metaphyseal cupping and fraying. C26836 Nutritional Disorder C118464 Pediatric Adverse Events Terminology C C26894 Thyroiditis Thyroiditis Inflammation of the thyroid gland. This category includes Hashimoto thyroiditis, Riedel thyroiditis, acute thyroiditis, subacute thyroiditis, and radiation-induced thyroiditis. Inflammation of the thyroid gland. C3009 Endocrine System Disorder C118464 Pediatric Adverse Events Terminology C C2870 Aplastic Anemia Aplastic Anemia Anemia resulting from bone marrow failure (aplastic or hypoplastic bone marrow). The production of erythroblasts and red cells is markedly decreased, and it may be associated with decreased production of granulocytes (granulocytopenia) and platelets (thrombocytopenia) as well. Aplastic anemia may be idiopathic or secondary due to bone marrow damage by toxins, radiation, or immunologic factors. A syndrome of bone marrow failure characterized by peripheral pancytopenia and marrow hypoplasia. C2869 Anemia C118464 Pediatric Adverse Events Terminology C C3073 Gynecomastia Gynecomastia Development of breast tissue in males. Presence of breast tissue in males. C36285 Endocrine System Finding C118464 Pediatric Adverse Events Terminology C C3123 Hyperthyroidism Hyperthyroidism Overactivity of the thyroid gland resulting in overproduction of thyroid hormone and increased metabolic rate. Causes include diffuse hyperplasia of the thyroid gland (Graves' disease), single nodule in the thyroid gland, and thyroiditis. The symptoms are related to the increased metabolic rate and include weight loss, fatigue, heat intolerance, excessive sweating, diarrhea, tachycardia, insomnia, muscle weakness, and tremor. Increased secretion of thyroid hormone(s) by the thyroid gland. C3009 Endocrine System Disorder C118464 Pediatric Adverse Events Terminology C C43263 Diabetes Insipidus Diabetes Insipidus A disorder characterized by excretion of large amounts of urine, accompanied by excessive thirst. Causes include deficiency of antidiuretic hormone or failure of the kidneys to respond to antidiuretic hormone. It may also be drug-related. A condition characterized by excretion of large amounts of dilute urine, accompanied by excessive thirst. Causes include deficiency of antidiuretic hormone or failure of the kidneys to respond to antidiuretic hormone. C3009 Endocrine System Disorder C118464 Pediatric Adverse Events Terminology C C48259 Hyperparathyroidism Hyperparathyroidism Hyperfunction of the parathyroid glands resulting in the overproduction of parathyroid hormone. It may be primary or secondary; primary hyperparathyroidism is caused by parathyroid adenoma, parathyroid hyperplasia, parathyroid carcinoma, and multiple endocrine neoplasia. It is associated with hypercalcemia and hypophosphatemia. Signs and symptoms include weakness, fatigue, nausea, vomiting, constipation, depression, bone pain, osteoporosis, cystic bone lesions, and kidney stones. Secondary hyperparathyroidism is caused by the chronic stimulation of the parathyroid glands in patients with chronic renal failure, rickets, and malabsorption syndromes. Elevated concentration of parathyroid hormone. Causes include conditions originating within the parathyroid glands (primary), in response to hypocalcemia and hyperphosphatemia (secondary), and renal disease (tertiary). Characteristics may include polyuria, polydipsia, constipation, lethargy, cognitive dysfunction, hypercalciuria, nephrolithiasis, and bone demineralization or reduced bone mineral density. C3009 Endocrine System Disorder C118464 Pediatric Adverse Events Terminology C C48280 Primary Hyperparathyroidism Primary Hyperparathyroidism Hyperfunction of the parathyroid glands resulting in the overproduction of parathyroid hormone. It is caused by parathyroid adenoma, parathyroid hyperplasia, parathyroid carcinoma, and multiple endocrine neoplasia. It is associated with hypercalcemia and hypophosphatemia. Signs and symptoms include weakness, fatigue, nausea, vomiting, constipation, depression, bone pain, osteoporosis, cystic bone lesions, and kidney stones. Hyperparathyroidism due to a condition originating within the parathyroid glands, resulting in hypercalcemia due to increased release of calcium and phosphate from bone matrix, increased renal calcium reabsorption, and increased renal production of 1,25-dihydroxyvitamin D, which increases intestinal absorption of calcium. Primary hyperparathyroidism is also associated with hypophosphatemia as a result of phosphaturia. Clinical features include weakness, fatigue, nausea, vomiting, constipation, depression, and, if chronic, bone pain, osteoporosis, cystic bone lesions, and kidney stones. C3009 Endocrine System Disorder C118464 Pediatric Adverse Events Terminology C C61443 Amenorrhea Amenorrhea The absence of menses in a woman who has achieved reproductive age. The absence of menses in a female individual who has achieved reproductive age. C27020 Female Reproductive System Disorder C118464 Pediatric Adverse Events Terminology C C61444 Hirsutism Hirsutism Male-pattern hair growth on a female. Male-pattern hair growth in a female individual. C36281 Integumentary System Finding C118464 Pediatric Adverse Events Terminology C C62587 Delayed Puberty Delayed Puberty Constitutional Growth Delay|Pubertal Delay Unusually late sexual maturity. Lack of onset of breast development by the age of 13 years in girls and the absence of testicular enlargement by the age of 13-14 years in boys. C36285 Endocrine System Finding C118464 Pediatric Adverse Events Terminology C C7541 Retinoblastoma Retinoblastoma A malignant tumor that originates in the nuclear layer of the retina. As the most common primary tumor of the eye in children, retinoblastoma is still relatively uncommon, accounting for only 1% of all malignant tumors in pediatric patients. Approximately 95% of cases are diagnosed before age 5. These tumors may be multifocal, bilateral, congenital, inherited, or acquired. Seventy-five percent of retinoblastomas are unilateral; 60% occur sporadically. A predisposition to retinoblastoma has been associated with 13q14 cytogenetic abnormalities. Patients with the inherited form also appear to be at increased risk for secondary nonocular malignancies such as osteosarcoma, malignant fibrous histiocytoma, and fibrosarcoma. A malignant tumor that originates in the nuclear layer of the retina. As the most common primary tumor of the eye in children, retinoblastoma is still relatively uncommon, accounting for only 1% of all malignant tumors in pediatric patients. Approximately 95% of cases are diagnosed before age 5. These tumors may be multifocal, bilateral, congenital, inherited, or acquired. Seventy-five percent of retinoblastomas are unilateral; 60% occur sporadically. A predisposition to retinoblastoma has been associated with 13q14 cytogenetic abnormalities. Patients with the inherited form also appear to be at increased risk for secondary nonocular malignancies such as osteosarcoma, malignant fibrous histiocytoma, and fibrosarcoma. C9305 Cancer C118464 Pediatric Adverse Events Terminology C C78350 Hypoparathyroidism Hypoparathyroidism An endocrine disorder characterized by decreased production of parathyroid hormone by the parathyroid glands. It is usually caused by damage of the parathyroid glands during head and neck surgery. Signs and symptoms include muscle cramps, abdominal pain, dry skin, brittle nails, cataracts, tetany, and convulsions. Decreased production or secretion of parathyroid hormone by the parathyroid gland, resulting in hypocalcemia due to decreased release of calcium and phosphate from bone matrix, decreased renal calcium reabsorption, and decreased renal production of 1,25-dihydroxyvitamin D-3, which decreases intestinal absorption of calcium. Hypoparathyroidism is also associated with hyperphosphatemia as a result of hypophosphaturia. C3009 Endocrine System Disorder C118464 Pediatric Adverse Events Terminology C C79704 Precocious Puberty Precocious Puberty Unusually early sexual maturity. Onset and progression of breast development before the age of 8 years in girls and testicular enlargement before the age of 9 years in boys. C36285 Endocrine System Finding C118464 Pediatric Adverse Events Terminology C C84533 Acromegaly Acromegaly A syndrome characterized by enlargement of the hands, feet, ears, nose, lips, and tongue, skin thickening and swelling of internal organs. It is caused by overproduction of growth hormone in the pituitary gland, usually by a pituitary adenoma. Excessive growth of body tissues due to overproduction of growth hormone in an individual who has completed linear growth. C3009 Endocrine System Disorder C118464 Pediatric Adverse Events Terminology C C84919 Nephrogenic Diabetes Insipidus Nephrogenic Diabetes Insipidus Diabetes insipidus caused by insensitivity of the kidneys to antidiuretic hormone. Diabetes insipidus caused by insensitivity of the kidneys to antidiuretic hormone (vasopressin), which is caused by mutation(s) in the AVPR2 gene, encoding the vasopressin V2 receptor (antidiuretic hormone receptor), or by mutation(s) in the AQP2 gene, encoding aquaporin-2. Inheritance may by X-linked (AVPR2) or autosomal dominant or recessive (AQP2). C43263 Diabetes Insipidus C118464 Pediatric Adverse Events Terminology C C84978 Osteochondrodysplasia Osteochondrodysplasia Congenital Skeletal Dysplasia|Skeletal Dysplasia A term referring to disorders characterized by abnormalities in the development of bones and cartilage. Abnormalities in development and growth of bone and cartilage. C89337 Congenital Musculoskeletal Defect C118464 Pediatric Adverse Events Terminology C C27191 Hashimoto Thyroiditis Hashimoto Thyroiditis Chronic Lymphocytic Thyroiditis|Hashimoto Disease|Hashimoto's Disease|Hashimoto's Thyroiditis|Lymphocytic Thyroiditis An autoimmune disorder caused by the production of autoantibodies against thyroid tissue. There is progressive destruction of the thyroid follicles leading to hypothyroidism. An autoimmune disorder characterized by inflammation and lymphocytic infiltration of the thyroid gland, sometimes associated with reduced thyroid function. C3009 Endocrine System Disorder C118464 Pediatric Adverse Events Terminology C C2902 Coagulation Disorder Coagulation Disorder Coagulation Defect|Coagulopathy A condition in which there is a deviation from or interruption of the normal coagulation properties of the blood. A condition of abnormal blood clotting or bleeding. C2931 Cardiovascular Disorder C26323 Hematologic Disorder C118464 Pediatric Adverse Events Terminology C C75545 Hemolytic Uremic Syndrome Hemolytic Uremic Syndrome HUS|Hemolytic-Uremic Syndrome Acute kidney injury associated with microangiopathic hemolytic anemia and thrombocytopenia. Acute kidney injury associated with microangiopathic hemolytic anemia and thrombocytopenia. C26323 Hematologic Disorder C118464 Pediatric Adverse Events Terminology C C113352 Primary Ovarian Failure Primary Ovarian Failure Hypergonadotropic Hypogonadism (Female) Absent or premature cessation of ovarian function due to a pathologic process originating within the ovaries. Absent or premature cessation of ovarian function due to an issue originating within the ovaries. C3009 Endocrine System Disorder C118464 Pediatric Adverse Events Terminology C C3063 Graft Versus Host Disease Graft Versus Host Disease GvHD A reaction, which may be fatal, in an immunocompromised subject (host) who has received an antigenically incompatible tissue transplant (graft) from an immunocompetent donor. The reaction is secondary to the activation of the transplanted cells against those host tissues that express an antigen not expressed by the donor, and is seen most commonly following bone marrow transplantation; acute disease is seen after 5-40 days, and chronic disease occurs weeks to months after transplantation. A reaction, which may be fatal, in an immunocompromised subject (host) who has received an antigenically incompatible tissue transplant (graft) from an immunocompetent donor. The reaction is secondary to the activation of the transplanted cells against those host tissues that express an antigen not expressed by the donor, and is seen most commonly following stem cell transplantation; acute disease is seen after 5-40 days, and chronic disease occurs weeks to months after transplantation. C3507 Immune System Disorder C118464 Pediatric Adverse Events Terminology C C3171 Acute Myeloid Leukemia Acute Myeloid Leukemia AML|Acute Granulocytic Leukemia|Acute Myelocytic Leukemia|Acute Myelogenous Leukemia A clonal expansion of myeloid blasts in the bone marrow, blood or other tissues. The classification of acute myeloid leukemias (AMLs) encompasses four major categories: 1) AML with recurrent genetic abnormalities; 2) AML with multilineage dysplasia; 3) Therapy-related AML; 4) AML not otherwise specified. The required bone marrow or peripheral blood blast percentage for the diagnosis of AML is 20% (WHO classification). A rapidly progressive cancer of the blood and bone marrow consisting of the proliferation of abnormal myeloblasts, which are immature, dysfunctional white blood cells. C3161 Leukemia C118464 Pediatric Adverse Events Terminology