A C101034 Intentional Trauma Intentional Trauma Non-accidental Trauma An injury that is not the result of an accident or natural causes. An injury that is not the result of an accident or natural causes. C3671 Injury C118464 Pediatric Adverse Events Terminology A C113303 Adipose Tissue Deposition Adipose Tissue Deposition The deposition of lipids in tissue. The deposition of lipids in tissue. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C115149 Adenovirus Infection Adenovirus Infection An infectious process caused by adenovirus. The virus may cause respiratory illness, conjunctivitis, gastroenteritis, and cystitis. An infectious process caused by adenovirus. The virus may cause respiratory illness, conjunctivitis, gastroenteritis, and cystitis. C3439 Viral Infection C118464 Pediatric Adverse Events Terminology A C115248 Methicillin-Resistant Staphylococcus Aureus Infection Methicillin-Resistant Staphylococcus Aureus Infection A bacterial infection that is caused by Staphylococcus aureus and is resistant to methicillin treatment. A bacterial infection that is caused by Staphylococcus aureus and is resistant to methicillin treatment. C2890 Bacterial Disease C118464 Pediatric Adverse Events Terminology A C116770 Retinopathy of Prematurity Stage 0 Retinopathy of Prematurity Stage 0 Prior to the development of ROP in the premature infant, vascularization of the retina is incomplete or immature. In Stage 0, there is no clear demarcation line between vascularized and non-vascularized retina. Prior to the development of ROP in the premature infant, vascularization of the retina is incomplete or immature. In Stage 0, there is no clear demarcation line between vascularized and non-vascularized retina. C34982 Retinopathy of Prematurity C118464 Pediatric Adverse Events Terminology A C116897 Fontanelle Bulging Fontanelle Bulging Membranous areas between cranial bones in a newborn that appear elevated or full. Membranous areas between cranial bones in a newborn that appear elevated or full. C118807 Newborn or Infant Finding C118464 Pediatric Adverse Events Terminology A C121556 Back Arching Back Arching A convex curvature of the spine that occurs when an individual thrusts forward the shoulders and pulls back the abdomen. A convex curvature of the spine that occurs when an individual thrusts forward the shoulders and pulls back the abdomen. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C121557 Bloody Discharge Bloody Discharge Bloody Drainage The leaking of serosanguinous fluids from an orifice or wound. The leaking of serosanguinous fluids from an orifice or wound. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C121558 Breath Holding Breath Holding Episodic apnea, which is more common in young children and usually resolves by age six. Episodic apnea, which is more common in young children and usually resolves by age six. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C121560 Cat Bite Cat Bite A wound received from the teeth of a cat. A wound received from the teeth of a cat. C3671 Injury C118464 Pediatric Adverse Events Terminology A C121562 Cystic Fibrosis Pulmonary Exacerbation Cystic Fibrosis Pulmonary Exacerbation An acute episode of worsening pulmonary symptoms related to cystic fibrosis. An acute episode of worsening pulmonary symptoms related to cystic fibrosis. C26871 Respiratory System Disorder C118464 Pediatric Adverse Events Terminology A C121574 Hypophagia Hypophagia Decreased Oral Intake|Poor Feeding|Poor Oral Intake Reduced ingestion of food. Reduced ingestion of food. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C121577 Pulmonary Function Test Decreased Pulmonary Function Test Decreased A decrease in any of the parameters used to measure the mechanical function of the lungs and upper airway. A decrease in any of the parameters used to measure the mechanical function of the lungs and upper airway. C36292 Laboratory Test Result C118464 Pediatric Adverse Events Terminology A C121582 Drooling Drooling Saliva spilling out of the mouth. Saliva spilling from the mouth. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C121588 Foreign Body Ingestion Foreign Body Ingestion The swallowing of an item not intended for consumption. The swallowing of an item not intended for consumption. C3671 Injury C118464 Pediatric Adverse Events Terminology A C121589 Central Line Complication Central Line Complication A problem with a central venous access catheter or site of insertion. A problem with a central venous access catheter or site of insertion. C62996 C118464 Pediatric Adverse Events Terminology A C121604 Catheter-Related Inflammation Catheter-Related Inflammation Inflammation associated with the use of a catheter. Inflammation associated with the use of a catheter. C62996 C118464 Pediatric Adverse Events Terminology A C121607 Central Line Infection Central Line Infection An infectious process related to a central venous catheter. An infectious process related to a central venous catheter. C26726 Infectious Disorder C118464 Pediatric Adverse Events Terminology A C121616 Wound Discharge Wound Discharge The material exuded from a wound, either surgical or traumatic. The material exuded from a wound, either surgical or traumatic. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C121623 Aphagia Aphagia The inability or refusal to swallow. The inability or refusal to swallow. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C121624 Agonal Respiration Agonal Respiration Gasping An abnormal breathing pattern originating from lower brainstem neurons and characterized by labored breaths, gasping, and, often, myoclonus and grunting. An abnormal breathing pattern originating from lower brainstem neurons and characterized by labored breaths, gasping, and, often, myoclonus and grunting. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C121626 Airway Compromise Airway Compromise The inhibition of normal respiration by physical obstruction(s) to the airway. The inhibition of normal respiration by physical obstruction(s) to the airway. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C121627 Altered Level of Consciousness Altered Level of Consciousness A level of awareness and arousal other than normal. A level of awareness and arousal other than normal. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C121628 Altered Mental Status Altered Mental Status A change to an individual's judgment, orientation (to place, time, and self), intellectual functioning, or mood from their baseline. A change to an individual's judgment, orientation (to place, time, and self), intellectual functioning, or mood from their baseline. C3858 Mental and Behavioral Signs and Symptoms C118464 Pediatric Adverse Events Terminology A C121629 Disturbance of Temperature Regulation Disturbance of Temperature Regulation Any condition characterized by an inability to regulate body temperature. Any condition characterized by an inability to regulate body temperature. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C121630 Increased Respiratory Secretion Increased Respiratory Secretion Increased Respiratory Secretions An increase in respiratory secretions. An increase in respiratory secretions. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C121661 Intrusive Thought Intrusive Thought An unwelcome and persistent idea, image or thought that is upsetting to an individual. An unwelcome and persistent idea, image, or thought that is upsetting to an individual. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C121669 Disordered Eating Disordered Eating Abnormal eating behaviors, including binge eating, compulsive eating, emotional eating, night eating, and self-induced vomiting, though not at a level that rises to the diagnosis of eating disorder. Abnormal eating behaviors, including binge eating, compulsive eating, emotional eating, night eating, and self-induced vomiting, though not at a level that rises to the diagnosis of eating disorder. C35470 Behavioral Disorder C118464 Pediatric Adverse Events Terminology A C122408 Pulmonary Nodules Pulmonary Nodules Multiple, small, round or oval, benign or malignant growths in the lung(s), which can be due to infectious, inflammatory, or neoplastic processes. Multiple, small, round or oval, benign or malignant growths in the lung(s), which can be due to infectious, inflammatory, or neoplastic processes. C26871 Respiratory System Disorder C118464 Pediatric Adverse Events Terminology A C122409 Ostomy Site Pain Ostomy Site Pain Pain at the site of an ostomy. Pain at the site of an ostomy. C3303 Pain C118464 Pediatric Adverse Events Terminology A C122410 Absence of Bowel Movement Absence of Bowel Movement The lack of any bowel movements. The lack of any bowel movements. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C122411 Scleral Icterus Scleral Icterus Yellowing of the white part of the eyes, often due to a rise in bilirubin levels. Yellowing of the white part of the eyes, often due to a rise in bilirubin levels. C26767 Eye Disorder C118464 Pediatric Adverse Events Terminology A C122412 Vaso-Occlusive Crisis Vaso-Occlusive Crisis Vaso-Occlusive Crisis An exacerbation of sickle cell disease. An exacerbation of sickle cell disease. C35117 Vascular Disorder C118464 Pediatric Adverse Events Terminology A C122413 Ulcerative Colitis Flare Ulcerative Colitis Flare An exacerbation of ulcerative colitis. An exacerbation of ulcerative colitis. C2990 Gastrointestinal Disorder C118464 Pediatric Adverse Events Terminology A C122414 Autoimmune Encephalitis Autoimmune Encephalitis Inflammation of the brain secondary to an immune response triggered by the body itself. Inflammation of the brain secondary to an immune response triggered by the body itself. C2934 Central Nervous System Disorder C118464 Pediatric Adverse Events Terminology A C122416 Refusal to Bear Weight Refusal to Bear Weight A reluctance to place any body weight on a limb, which is most commonly secondary to pain or discomfort. A reluctance to place any body weight on a limb, which is most commonly secondary to pain or discomfort. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C122419 Dog Bite Dog Bite A wound received from the teeth of a dog. A wound received from the teeth of a dog. C3671 Injury C118464 Pediatric Adverse Events Terminology A C122425 Port Site Infection Port Site Infection An infection at an anatomic location used for vascular access. An infection at an anatomic location used for vascular access. C26726 Infectious Disorder C118464 Pediatric Adverse Events Terminology A C122426 Acquired Cytomegaloviral Infection Acquired Cytomegaloviral Infection An infection with the Cytomegalovirus that is not present from birth. An infection with the Cytomegalovirus that is not present from birth. C3439 Viral Infection C118464 Pediatric Adverse Events Terminology A C122427 Congenital Cytomegaloviral Infection Congenital Cytomegaloviral Infection An infection with the Cytomegalovirus that is present from birth. An infection with the Cytomegalovirus that is present from birth. C96411 Childhood Viral Disease C118464 Pediatric Adverse Events Terminology A C122430 Abnormal Behavior Abnormal Behavior Behavioral Disturbance|Not Acting Normal|Not Acting Self Conduct that is unusual for the individual. Conduct that is unusual for the individual. C3858 Mental and Behavioral Signs and Symptoms C118464 Pediatric Adverse Events Terminology A C122435 Impaired Balance Impaired Balance Loss of Balance A deficit in equilibrium, which may manifest as unsteady ambulation or inability to maintain an upright position. A deficit in equilibrium, which may manifest as unsteady ambulation or inability to maintain an upright position. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C122437 Positive Blood Culture Positive Blood Culture Positive Blood Culture A laboratory test result demonstrating the presence of a specific organism in a blood sample after culture. A laboratory test result demonstrating the presence of a specific organism in a blood sample after culture. C36292 Laboratory Test Result C118464 Pediatric Adverse Events Terminology A C122438 Blood Urea Nitrogen Increased Blood Urea Nitrogen Increased Elevated Blood Urea Nitrogen Laboratory results demonstrating an increase in the concentration of urea nitrogen in a blood sample. Laboratory results demonstrating an increase in the concentration of urea nitrogen in a blood sample. C36292 Laboratory Test Result C118464 Pediatric Adverse Events Terminology A C122439 Dislodged Catheter Dislodged Catheter A catheter that has moved from its intended location. A catheter that has moved from its intended location. C62950 C118464 Pediatric Adverse Events Terminology A C122443 Coombs Test Positive Coombs Test Positive Positive Coombs Test A laboratory test result demonstrating the presence of antibodies that act against red blood cells. A laboratory test result demonstrating the presence of antibodies that act against red blood cells. C36292 Laboratory Test Result C118464 Pediatric Adverse Events Terminology A C122444 Decreased Physical Activity Decreased Physical Activity A reduction in the normal physical activity for an individual. A reduction in the normal physical activity for an individual. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C122445 Feeding Tube Complication Feeding Tube Complication Any problem with a feeding tube or its site of insertion. Any problem with a feeding tube or its site of insertion. C62996 C118464 Pediatric Adverse Events Terminology A C122470 Fistula Discharge Fistula Discharge Fistula Drainage The leakage of a substance from a fistula. The leakage of a substance from a fistula. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C122478 Gait Unsteady Gait Unsteady A shaky or wobbly manner of walking. A shaky or wobbly manner of walking. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C122507 Hemoglobin A1c Increased Hemoglobin A1c Increased A laboratory test result demonstrating an increase in the glycosylated hemoglobin in a blood sample. A laboratory test result demonstrating an increase in the glycosylated hemoglobin in a blood sample. C36292 Laboratory Test Result C118464 Pediatric Adverse Events Terminology A C122512 Ketonuria Ketonuria The presence of ketone bodies in the urine. The presence of ketone bodies in the urine. C36292 Laboratory Test Result C118464 Pediatric Adverse Events Terminology A C122513 Hyperlactemia Hyperlactemia Elevated Lactate Level Abnormally high level of lactate in the blood. Abnormally high concentration of lactate in the blood. C36292 Laboratory Test Result C118464 Pediatric Adverse Events Terminology A C122516 Abnormal Liver Function Test Abnormal Liver Function Test Atypical results found on serum liver enzyme testing, which may indicate significant disease and/or disease progression. Atypical results found on serum liver enzyme testing, which may indicate significant disease and/or disease progression. C36292 Laboratory Test Result C118464 Pediatric Adverse Events Terminology A C122523 Methicillin-Resistant Staphylococcus Aureus Pneumonia Methicillin-Resistant Staphylococcus Aureus Pneumonia Pneumonia that is caused by Staphylococcus aureus and is resistant to methicillin treatment. Pneumonia that is caused by Staphylococcus aureus and is resistant to methicillin treatment. C2890 Bacterial Disease C118464 Pediatric Adverse Events Terminology A C122526 Mycoplasmal Pneumonia Mycoplasmal Pneumonia Pneumonia caused by Mycoplasma pneumoniae. Signs and symptoms include productive cough, fever, chills, shortness of breath, and chest pain. Pneumonia caused by Mycoplasma pneumoniae. Signs and symptoms include productive cough, fever, chills, shortness of breath, and chest pain. C2890 Bacterial Disease C118464 Pediatric Adverse Events Terminology A C122527 Disrupted Suture Disrupted Suture Stitches Coming Loose The loss of tension or continuity of sutures. The loss of tension or continuity of sutures. C62950 C118464 Pediatric Adverse Events Terminology A C122528 Violent Behavior Violent Behavior Any action that results in intimidation, harm, damage, or destruction of someone or something. Any action that results in intimidation, harm, damage, or destruction of someone or something. C3858 Mental and Behavioral Signs and Symptoms C118464 Pediatric Adverse Events Terminology A C122529 Unresponsive to Stimuli Unresponsive to Stimuli An individual whose level of consciouness is such that he is not responsive to any stimulus. An individual whose level of consciousness is such that he is not responsive to any stimulus. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C122572 Rhinovirus Infection Rhinovirus Infection An infectious process caused by rhinovirus. The virus usually causes upper respiratory infections, but can infect the lower tract as well. An infectious process caused by rhinovirus. The virus usually causes upper respiratory infections, but can infect the lower tract as well. C3439 Viral Infection C118464 Pediatric Adverse Events Terminology A C122573 Screaming Screaming A loud, vociferous cry or yell; it can be the result of many emotions, including pain, excitement, or fear. A loud, vociferous cry or yell; it can be the result of many emotions, including pain, excitement, or fear. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C122574 Lupus Flare Lupus Flare An exacerbation of the chronic disease lupus. An exacerbation of the chronic disease lupus. C3507 Immune System Disorder C118464 Pediatric Adverse Events Terminology A C122575 Positive Herpes Simplex Virus Culture Positive Herpes Simplex Virus Culture Laboratory test results demonstrating the presence of the Herpes Simplex virus in a specimen. Laboratory test results demonstrating the presence of the Herpes Simplex virus in a specimen. C36292 Laboratory Test Result C118464 Pediatric Adverse Events Terminology A C122576 Staphylococcus Aureus Infection Staphylococcus Aureus Infection An infectious process in which the bacteria Staphylococcus aureus is present. An infectious process in which the bacteria Staphylococcus aureus is present. C2890 Bacterial Disease C118464 Pediatric Adverse Events Terminology A C122577 Status Asthmaticus Status Asthmaticus An acute exacerbation of asthma, characterized by inadequate response to initial bronchodilators. An acute exacerbation of asthma, characterized by an inadequate response to the initial use of bronchodilators and the progressive worsening of bronchial obstruction and shortness of breath, which can result in the need for mechanical ventilation and/or possibly death. C26871 Respiratory System Disorder C118464 Pediatric Adverse Events Terminology A C122578 Throat Tightening Throat Tightening The sensation of constriction or contraction in the throat area. The sensation of constriction or contraction in the throat area. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C122579 Phonophobia Phonophobia A fear of sounds, which can include fear of voices, including one's own voice, in addition to other sounds. A fear of sounds, which can include fear of voices, including one's own voice, in addition to other sounds. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C122580 Pneumatosis Intestinalis Pneumatosis Intestinalis The presence of gas within the wall of the large or small intestine. The presence of gas within the wall of the large or small intestine. C2990 Gastrointestinal Disorder C118464 Pediatric Adverse Events Terminology A C122581 Postoperative Infection Postoperative Infection Any infection documented following a surgical procedure that was not evident or suspected prior to the procedure. An infection documented following a surgical procedure that was not present or incubating prior to the procedure. C26726 Infectious Disorder C118464 Pediatric Adverse Events Terminology A C122582 Positive Pseudomonas Culture Positive Pseudomonas Culture A laboratory test result demonstrating the presence of bacteria from the genus Pseudomonas in a sample after culture. A laboratory test result demonstrating the presence of bacteria from the genus Pseudomonas in a sample after culture. C36292 Laboratory Test Result C118464 Pediatric Adverse Events Terminology A C122583 Hemiparesis Hemiparesis Weakness or incomplete paralysis of either the left or right side of the body. Weakness or incomplete paralysis of either the left or right side of the body. C4731 Neuropathy C118464 Pediatric Adverse Events Terminology A C122587 Indwelling Urinary Catheter Indwelling Urinary Catheter A hollow tube that is inserted and left in the bladder to promote the drainage of urine. A hollow tube that is inserted and left in the bladder to promote the drainage of urine. C62103 Device C118464 Pediatric Adverse Events Terminology A C122639 Duodenostomy Site Duodenostomy Site A surgically created external opening into the duodenum. A surgically created external opening into the duodenum. C122645 Enterostomy Site C118464 Pediatric Adverse Events Terminology A C122640 Colostomy Site Colostomy Site A surgically created external opening into the colon. A surgically created external opening into the colon. C122645 Enterostomy Site C118464 Pediatric Adverse Events Terminology A C122641 Cystostomy Site Cystostomy Site A surgically created external opening into the anterior wall of the bladder. A surgically created external opening into the anterior wall of the bladder. C122638 Ostomy Sites C118464 Pediatric Adverse Events Terminology A C122642 Ileostomy Site Ileostomy Site A surgically created external opening into the ileum. A surgically created external opening into the ileum. C122645 Enterostomy Site C118464 Pediatric Adverse Events Terminology A C122643 Tracheostomy Site Tracheostomy Site A surgically created external opening into the trachea. A surgically created external opening into the trachea. C122638 Ostomy Sites C118464 Pediatric Adverse Events Terminology A C122644 Urostomy Site Urostomy Site A surgically created external opening into the urinary tract. A surgically created external opening into the urinary tract. C122638 Ostomy Sites C118464 Pediatric Adverse Events Terminology A C122645 Enterostomy Site Enterostomy Site A surgically created external opening into the intestine. A surgically created external opening into the intestine. C122638 Ostomy Sites C118464 Pediatric Adverse Events Terminology A C122646 Gastrostomy Site Gastrostomy Site A surgically created external opening into the stomach. A surgically created external opening into the stomach. C122638 Ostomy Sites C118464 Pediatric Adverse Events Terminology A C122647 Jejunostomy Site Jejunostomy Site A surgically created external opening into the jejunum. A surgically created external opening into the jejunum. C122645 Enterostomy Site C118464 Pediatric Adverse Events Terminology A C122648 Nephrostomy Site Nephrostomy Site A surgically created external opening into the renal pelvis. A surgically created external opening into the renal pelvis. C122638 Ostomy Sites C118464 Pediatric Adverse Events Terminology A C122710 Medical Device Failure Medical Device Failure A medical device that is no longer functioning. A medical device that is no longer functioning. C78254 Device Complication C118464 Pediatric Adverse Events Terminology A C122711 Medical Device Malfunction Medical Device Malfunction A medical device that is functioning incorrectly. A medical device that is functioning incorrectly. C78254 Device Complication C118464 Pediatric Adverse Events Terminology A C122712 Medical Device Dislodged Medical Device Dislodged A medical device that was placed properly, but which has moved from the intended location. A medical device that was placed properly, but which has moved from the intended location. C78254 Device Complication C118464 Pediatric Adverse Events Terminology A C122713 Medical Device Misplaced Medical Device Misplaced A medical device that was placed in an unintended location. A medical device that was placed in an unintended location. C78254 Device Complication C118464 Pediatric Adverse Events Terminology A C122721 Hypercarbia Hypercarbia Excessive concentration of carbon dioxide in the blood. Excessive concentration of carbon dioxide in the blood. C36292 Laboratory Test Result C118464 Pediatric Adverse Events Terminology A C122722 Accidental Drug Ingestion Accidental Medicine Ingestion The unintentional consumption of a drug. The unintentional consumption of a drug. C3367 Finding C118464 Pediatric Adverse Events Terminology A C122784 Tracheobronchitis Tracheobronchitis Inflammation of the tracheobronchial tree. Inflammation of the tracheobronchial tree. C26871 Respiratory System Disorder C118464 Pediatric Adverse Events Terminology A C122785 Pneumatosis Pneumatosis The presence of gas in an anatomical location where it is not normally found. The presence of gas in an anatomical location where it is not normally found. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C122786 Incarcerated Inguinal Hernia Incarcerated Inguinal Hernia The trapping of bowel or omentum inside the inguinal canal that cannot be reduced, resulting in inflammation, pain, nausea, and possible bowel obstruction. The trapping of bowel or omentum inside the inguinal canal that cannot be reduced, resulting in inflammation, pain, nausea, and possible bowel obstruction. C34690 Inguinal Hernia C118464 Pediatric Adverse Events Terminology A C122818 Closure Patent Ductus Arteriosus Closure Patent Ductus Arteriosus The closing of the ductus arteriosus; this can occur naturally or as a result of a therapeutic procedure. The closing of the ductus arteriosus; this can occur naturally or as a result of a therapeutic procedure. C35552 Cardiovascular Finding C118464 Pediatric Adverse Events Terminology A C122821 Elevated Alkaline Phosphatase Elevated Alkaline Phosphatase An elevated concentration of alkaline phosphatase in the blood. An elevated concentration of alkaline phosphatase in the blood. C36292 Laboratory Test Result C118464 Pediatric Adverse Events Terminology A C122822 Cholelithiasis Cholelithiasis Gallstones The presence of calculi in the gallbladder. The presence of calculi in the gallbladder. C2990 Gastrointestinal Disorder C118464 Pediatric Adverse Events Terminology A C25534 Induration Induration The quality of being hard, the process of hardening, or an abnormally hard spot or place, particularly of the skin. The quality of being hard, the process of hardening, or an abnormally hard spot or place, particularly of the skin. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C26726 Infectious Disorder Infectious Disorder A disorder resulting from the presence and activity of a microbial, viral, fungal, or parasitic agent. It can be transmitted by direct or indirect contact. A disorder resulting from the presence and activity of a microbial, viral, fungal, or parasitic agent. It can be transmitted by direct or indirect contact. C2991 Disease or Disorder C118464 Pediatric Adverse Events Terminology A C26737 Cyanosis Cyanosis Blue Spells A bluish or purplish discoloration of the skin and mucous membranes resulting from a reduced concentration of oxygenated hemoglobin in the blood. A bluish or purplish discoloration of the skin and mucous membranes resulting from a reduced concentration of oxygenated hemoglobin in the blood. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C26796 Hydronephrosis Hydronephrosis The collection of urine in the renal pelvis that results in dilatation of the renal pelvis and calyces, which can be caused by obstruction of urine flow or vesicoureteral reflux. Signs and symptoms include flank pain, nausea, vomiting, fever, and dysuria. The collection of urine in the renal pelvis that results in dilatation of the renal pelvis and calyces, which can be caused by obstruction of urine flow or vesicoureteral reflux. Signs and symptoms include flank pain, nausea, vomiting, fever, and dysuria. C3149 Kidney Disease C118464 Pediatric Adverse Events Terminology A C26901 Erythema Erythema Redness Red discoloration of the skin caused by infectious agents, inflammation, drug hypersensitivity, or underlying disease. Red discoloration of the skin caused by infectious agents, inflammation, drug hypersensitivity, or underlying disease. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C28137 Oral Candidiasis Oral Candidiasis Infection of the mucosal lining of the mouth with the fungus Candida albicans. Infection of the mucosal lining of the mouth with the fungus Candida albicans. C26726 Infectious Disorder C118464 Pediatric Adverse Events Terminology A C28397 Asthma Asthma A chronic respiratory disease manifested as difficulty breathing due to the narrowing of bronchial passageways. A chronic respiratory disease caused by obstruction of the bronchi and small airways, and characterized by wheezing and shortness of breath. C26871 Respiratory System Disorder C118464 Pediatric Adverse Events Terminology A C2885 Ascites Ascites The accumulation of fluid in the peritoneal cavity, which may be serous, hemorrhagic, or the result of tumor metastasis to the peritoneum. The accumulation of fluid in the peritoneal cavity, which may be serous, hemorrhagic, or the result of tumor metastasis to the peritoneum. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C2975 Cystic Fibrosis Cystic Fibrosis A congenital, autosomal, metabolic disorder affecting the exocrine glands. The secretions of exocrine glands are abnormal, resulting in excessively viscid mucus production that causes obstruction of passageways, including pancreatic and bile ducts, intestines, and bronchi. Symptoms usually appear in childhood, and include meconium ileus, poor growth despite good appetite, malabsorption and foul bulky stools, chronic bronchitis with cough, recurrent pneumonia, bronchiectasis, emphysema, clubbing of the fingers, and salt depletion in hot weather secondary to increased sodium and chloride concentration in sweat. A congenital, autosomal, metabolic disorder affecting the exocrine glands. The secretions of exocrine glands are abnormal, resulting in excessively viscid mucus production that causes obstruction of passageways, including pancreatic and bile ducts, intestines, and bronchi. Symptoms usually appear in childhood, and include meconium ileus, poor growth despite good appetite, malabsorption and foul bulky stools, chronic bronchitis with cough, recurrent pneumonia, bronchiectasis, emphysema, clubbing of the fingers, and salt depletion in hot weather secondary to increased sodium and chloride concentration in sweat. C34816 Congenital Metabolic Disorder C118464 Pediatric Adverse Events Terminology A C3003 Effusion Effusion A collection of fluid in a body cavity, which may be the result of a non-neoplastic disorder (e.g. heart failure) or a tumor (e.g. carcinoma of the lung). A collection of fluid in a body cavity, which may be the result of a non-neoplastic disorder (e.g. heart failure) or a tumor (e.g. carcinoma of the lung). C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C30085 Muscle Contraction Muscle Contraction The process where thick (myosin) and thin (actin) filaments slide against each other to produce a shortening or tensing of the muscle cell or fiber. The process where thick (myosin) and thin (actin) filaments slide against each other to produce a shortening or tensing of the muscle cell or fiber. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C3063 Graft Versus Host Disease Graft Versus Host Disease A reaction, which may be fatal, in an immunocompromised subject (host) who has received an antigenically incompatible tissue transplant (graft) from an immunocompetent donor. The reaction is secondary to the activation of the transplanted cells against those host tissues that express an antigen not expressed by the donor, and is seen most commonly following bone marrow transplantation; acute disease is seen after 5-40 days, and chronic disease occurs weeks to months after transplantation. A reaction, which may be fatal, in an immunocompromised subject (host) who has received an antigenically incompatible tissue transplant (graft) from an immunocompetent donor. The reaction is secondary to the activation of the transplanted cells against those host tissues that express an antigen not expressed by the donor, and is seen most commonly following bone marrow transplantation; acute disease is seen after 5-40 days, and chronic disease occurs weeks to months after transplantation. C3507 Immune System Disorder C118464 Pediatric Adverse Events Terminology A C3094 Hemoptysis Hemoptysis Coughing up blood from the respiratory tract. Coughing up blood from the respiratory tract. C26871 Respiratory System Disorder C118464 Pediatric Adverse Events Terminology A C3285 Ocular Hypertension Ocular Hypertension Pressure Behind Eyeballs Abnormally high intraocular pressure. Abnormally high intraocular pressure. C26767 Eye Disorder C118464 Pediatric Adverse Events Terminology A C3354 Respiratory Syncytial Virus Infection Respiratory Syncytial Virus Infection Infection with the respiratory syncytial virus, an RNA virus of the genus Pneumovirus, in the family Paramyxoviridae, which is characterized by the formation of syncytia in tissue culture. It causes minor respiratory infection with rhinitis and cough in adults, but is capable of causing severe bronchitis and bronchopneumonia in young children. Infection with the respiratory syncytial virus, an RNA virus of the genus Pneumovirus, in the family Paramyxoviridae, which is characterized by the formation of syncytia in tissue culture. It causes minor respiratory infection with rhinitis and cough in adults, but is capable of causing severe bronchitis and bronchopneumonia in young children. C3439 Viral Infection C118464 Pediatric Adverse Events Terminology A C3376 Sleep Disorder Sleep Disorder A change from the patient's baseline sleeping pattern, in the hours slept and/or an alteration/dysfunction in the stages of sleep. A change from the patient's baseline sleeping pattern, in the hours slept and/or an alteration/dysfunction in the stages of sleep. C26835 Neurologic Disorder C118464 Pediatric Adverse Events Terminology A C3439 Viral Infection Viral Infection Any disease caused by a virus. Any disease caused by a virus. C26726 Infectious Disorder C118464 Pediatric Adverse Events Terminology A C34571 Interstitial Emphysema Pulmonary Interstitial Emphysema Pathologic accumulation of air in the interstitium of the lungs, which is caused by the rupture of alveoli and terminal bronchioles, and is most often seen in premature infants that need mechanical ventilation for respiratory distress syndrome. Pathologic accumulation of air in the interstitium of the lungs, which is caused by the rupture of alveoli and terminal bronchioles, and is most often seen in premature infants that need mechanical ventilation for respiratory distress syndrome. C3198 Lung Disorder C118464 Pediatric Adverse Events Terminology A C34596 Internal Strabismus Internal Strabismus Esotropia A form of strabismus in which one or both eyes are deviated medially. A form of strabismus in which one or both eyes are deviated medially. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C34630 Gagging Gagging The sudden, coordinated, involuntary contraction of pharyngeal muscles in an attempt to prevent any matter from passing into the posterior pharynx; it is stimulated by touching the posterior palate, tongue, or pharynx, or by psychic stimuli. The sudden, coordinated, involuntary contraction of pharyngeal muscles in an attempt to prevent any matter from passing into the posterior pharynx; it is stimulated by touching the posterior palate, tongue, or pharynx, or by psychic stimuli. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C3472 Severe Combined Immunodeficiency Severe Combined Immunodeficiency X-linked or autosomal recessive disorder characterized by defects of both humoral and cell mediated immunity, resulting in low or absent antibody levels, leukopenia, marked susceptibility to infections, and early death.--2004 X-linked or autosomal recessive disorder characterized by defects of both humoral and cell mediated immunity, resulting in low or absent antibody levels, leukopenia, marked susceptibility to infections, and early death.--2004 C3507 Immune System Disorder C118464 Pediatric Adverse Events Terminology A C34808 Mass Mass A benign or malignant pathologic structure in any part of the body, resulting from a neoplastic accumulation of cells, inflammatory cells, or cystic changes. A benign or malignant pathologic structure in any part of the body, resulting from a neoplastic accumulation of cells, inflammation, or cystic changes. C3262 Neoplasm C118464 Pediatric Adverse Events Terminology A C34825 Kawasaki Disease Kawasaki Disease A vasculitis characterized by inflammation of the arteries, particularly the coronary arteries. The vasculitis may lead to aneurysm formation and possibly, heart attacks. It affects young children who usually present with persistent high fever, redness of the mucous membranes of the mouth, redness of the palms and soles, skin rashes, lymphadenitis, and joint pain and swelling. Medium-sized vessel vasculitis seen primarily in young children with predilection for the coronary arteries. Diagnosis is based on clinical findings of persistent high fever, changes in lips and oral mucous membranes, erythema and edema of hands/feet and later desquamation, bilateral bulbar conjunctivitis, unilateral cervical adenopathy, polymorphous rash. C26912 Vasculitis C118464 Pediatric Adverse Events Terminology A C34832 Myoclonic Jerk Myoclonic Jerk A sudden, involuntary contraction of a muscle or group of muscles; these movements may develop as a symptom of a number of neurological diseases, including epilepsy, Parkinson's disease, Alzheimer's disease, or Creutzfeldt-Jacob disease. A sudden, involuntary contraction of a muscle or group of muscles; these movements may develop as a symptom of a number of neurological diseases, including epilepsy, Parkinson's disease, Alzheimer's disease, or Creutzfeldt-Jacob disease. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C34857 Numbness Numbness A loss of the sensation of feeling in an area of the body. A loss of the sensation of feeling in an area of the body. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C34938 Postoperative Hemorrhage Postoperative Hemorrhage Bleeding occurring after completion of a surgical procedure, which may occur immediately or may be delayed, and which may or may not be wound related. Bleeding occurring after completion of a surgical procedure, which may occur immediately or may be delayed, and which may or may not be wound related. C2959 Complication C118464 Pediatric Adverse Events Terminology A C35043 Stutter Stutter A speech disorder characterized by frequent sound or syllable repetitions, sound prolongations, or other dysfluencies that are inappropriate for the individual's age. A speech disorder characterized by frequent sound or syllable repetitions, sound prolongations, or other dysfluencies that are inappropriate for the individual's age. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C35082 Traumatic Subcutaneous Emphysema Traumatic Subcutaneous Emphysema The infiltration of air into the skin tissue secondary to traumatic tissue disruption. The infiltration of air into the skin tissue secondary to traumatic tissue disruption. C3671 Injury C118464 Pediatric Adverse Events Terminology A C35199 Otorrhea Otorrhea Ear Drainage Discharge or drainage of fluid from the ear. Discharge or drainage of fluid from the ear. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C35268 Macrocephaly Macrocephaly An abnormal increase in head circumference, which can have a variety of causes, including hydrocephalus, enlarged brain, and cranial hyperostosis. An abnormal increase in head circumference, which can have a variety of causes, including hydrocephalus, enlarged brain, and cranial hyperostosis. C2934 Central Nervous System Disorder C118464 Pediatric Adverse Events Terminology A C35294 Hepatic Mass Hepatic Mass A space-occupying pathologic process that affects the liver parenchyma. A space-occupying pathologic process that affects the liver parenchyma. C3262 Neoplasm C118464 Pediatric Adverse Events Terminology A C35295 Mediastinal Mass Mediastinal Mass A mass present in the mediastinal space. A mass present in the mediastinal space. C3262 Neoplasm C118464 Pediatric Adverse Events Terminology A C35448 Eye Discharge Eye Discharge Liquid exudate from the eye. Liquid exudate from the eye. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C35651 Post-Procedural Pain Post-Procedural Pain Pain experienced after a medical intervention through the time expected for associated acute effects to abate. Pain experienced after a medical intervention through the time expected for associated acute effects to abate. C3303 Pain C118464 Pediatric Adverse Events Terminology A C4376 Renal Failure Renal Failure An acute or chronic disorder characterized by the inability of the kidneys to adequately filter the blood substances, resulting in uremia and electrolyte imbalances. Acute renal failure is usually associated with oliguria or anuria, hyperkalemia, and pulmonary edema. Chronic renal failure is irreversible. Either form can require hemodialysis. An acute or chronic disorder, characterized by the inability of the kidneys to adequately filter the blood substances, resulting in uremia and electrolyte imbalances. Acute renal failure is usually associated with oliguria or anuria, hyperkalemia, and pulmonary edema. Chronic renal failure is irreversible. Either form can require hemodialysis. C3149 Kidney Disease C118464 Pediatric Adverse Events Terminology A C50437 Body Substance Discharge Body Substance Discharge The leakage of a substance from an orifice or wound. The leakage of a substance from an orifice or wound. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C50446 Laceration Laceration A cut or tear in any tissue. A cut or tear in any tissue. C3671 Injury C118464 Pediatric Adverse Events Terminology A C50458 Ambulation Difficulty Ambulation Difficulty Any persistent problem with walking. Any persistent problem with walking. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C50487 Cerebrospinal Fluid Leakage Cerebrospinal Fluid Leakage The loss of cerebrospinal fluid into the surrounding tissues. The loss of cerebrospinal fluid into the surrounding tissues. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C50494 Choking Choking Interference with respiration by compression or obstruction of the larynx or trachea. Interference with respiration by compression or obstruction of the larynx or trachea. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C50618 Intraocular Pressure Rise Intraocular Pressure Rise Increased Ocular Pressure Increased pressure of the intraocular fluid in the eye. Increased pressure of the intraocular fluid in the eye. C26767 Eye Disorder C118464 Pediatric Adverse Events Terminology A C50635 Loss of Consciousness Loss of Consciousness An inability to purposefully respond to stimuli. An inability to purposefully respond to stimuli. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C50640 Low Blood Oxygen Saturation Low Blood Oxygen Saturation Desaturation A low level of the degree to which oxygen is bound to hemoglobin given as a percentage calculated by dividing the maximum oxygen capacity into the actual oxygen content and multiplying by 100. Oxygen saturation usually is measured using pulse oximetry. A decrease in the concentration of oxyhemoglobin as contrasted to the concentration deoxyhemoglobin in the blood. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C50704 Postoperative Wound Infection Postoperative Wound Infection Infection of a surgical skin incision. Infection of a surgical skin incision. C26726 Infectious Disorder C118464 Pediatric Adverse Events Terminology A C50717 Purulent Discharge Purulent Discharge Pus-containing fluid that is draining from an orifice or wound. Pus-containing fluid that is draining from an orifice or wound. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C50795 Vaginal Discharge Vaginal Discharge Normal or abnormal secretions from the vagina. Mucus produced by the cervical glands is discharged from the vagina naturally, especially during the childbearing years. Causes of abnormal vaginal discharge include infectious agents (e.g., Neisseria gonorrhea, Chlamydia trachomatis, Trichomonas, and Candida albicans), the presence of foreign bodies, and cervical or vaginal cancer. Normal or abnormal secretions from the vagina. Mucus produced by the cervical glands is discharged from the vagina naturally, especially during the childbearing years. Causes of abnormal vaginal discharge include infectious agents (e.g., Neisseria gonorrhea, Chlamydia trachomatis, Trichomonas, and Candida albicans), the presence of foreign bodies, and cervical or vaginal cancer. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C53482 Influenza Influenza An acute viral infection of the respiratory tract, occurring in isolated cases, in epidemics, or in pandemics; it is caused by serologically different strains of viruses (influenzaviruses) designated A, B, and C, has a 3-day incubation period, and usually lasts for 3 to 10 days. It is marked by inflammation of the nasal mucosa, pharynx, and conjunctiva; headache; myalgia; often fever, chills, and prostration; and occasionally involvement of the myocardium or central nervous system. An acute viral infection of the respiratory tract, occurring in isolated cases, in epidemics, or in pandemics; it is caused by serologically different strains of viruses (influenzaviruses) designated A, B, and C, has a 3-day incubation period, and usually lasts for 3 to 10 days. It is marked by inflammation of the nasal mucosa, pharynx, and conjunctiva; headache; myalgia; often fever, chills, and prostration; and occasionally involvement of the myocardium or central nervous system. C3439 Viral Infection C118464 Pediatric Adverse Events Terminology A C54282 Rhinorrhea Rhinorrhea A discharge of fluid from the nose. A discharge of fluid from the nose. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C54355 Increased Drug Level Increased Drug Level A laboratory test result demonstrating an increased concentration of a specific drug. A laboratory test result demonstrating an increased concentration of a specific drug. C36292 Laboratory Test Result C118464 Pediatric Adverse Events Terminology A C77963 Crying Crying The shedding of tears associated with emotions, usually sadness but also joy or frustration. The shedding of tears associated with emotions, usually sadness, but also joy or frustration. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C78249 Increased Creatinine Increased Creatinine Elevated Creatinine A laboratory test result demonstrating an increased concentration of creatinine in a biological specimen. A laboratory test result demonstrating an increased concentration of creatinine in a biological specimen. C36292 Laboratory Test Result C118464 Pediatric Adverse Events Terminology A C78253 Depressed Level Of Consciousness Depressed Level Of Consciousness A neurologic state characterized by decreased ability to perceive and respond. A neurologic state characterized by decreased ability to perceive and respond. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C78254 Device Complication Device Complication Any problem arising from the use of a medical device. Any problem arising from the use of a medical device. C2959 Complication C118464 Pediatric Adverse Events Terminology A C78366 INR Increased INR Increased Elevated Prothrombin Time International Normalized Ratio|Supratherapeutic International Normalized Ratio A laboratory test result demonstrating an increased ratio of the patient's prothrombin time to a control sample. A laboratory test result demonstrating an increased ratio of the patient's prothrombin time to a control sample. C36292 Laboratory Test Result C118464 Pediatric Adverse Events Terminology A C78639 Tooth Infection Tooth Infection An infectious process affecting a tooth. An infectious process affecting a tooth. C26726 Infectious Disorder C118464 Pediatric Adverse Events Terminology A C80085 Hemoglobin Decreased Hemoglobin Decreased A laboratory test result demonstrating decreased levels of hemoglobin in a biological specimen. A laboratory test result demonstrating decreased levels of hemoglobin in a biological specimen. C36292 Laboratory Test Result C118464 Pediatric Adverse Events Terminology A C80522 Urine Output Decreased Urine Output Decreased A finding indicating that the urine production is less than 500 milliliters during a 24 hour period. A finding indicating that the urine production is less than 500 milliliters during a 24 hour period. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C84473 Atrial Septal Defect Atrial Septal Defect The presence of a defect (opening) in the septum that separates the two atria of the heart. It can be congenital or acquired. The presence of a defect (opening) in the septum that separates the two atria of the heart. It can be congenital or acquired. C84482 Cardiac Septal Defects C118464 Pediatric Adverse Events Terminology A C85022 Priapism Priapism Persistent and usually painful erection that lasts for at least four hours in the absence of physical or psychological stimulation, which can be caused by hematologic disorders, including sickle cell disease and leukemia, spinal cord injuries, and medications. Persistent and usually painful erection that lasts for at least four hours, in the absence of physical or psychological stimulation, which can be caused by hematologic disorders, including sickle cell disease and leukemia, spinal cord injuries, and medications. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C85231 Whooping Cough Whooping Cough A contagious bacterial respiratory infection caused by Bordetella pertussis. It is characterized by severe and uncontrollable cough, resulting in a whooping sound during breathing following the cough. A bacterial respiratory infection caused by Bordetella pertussis, which is characterized by severe and uncontrollable cough, resulting in a whooping sound during breathing following the cough. C26871 Respiratory System Disorder C118464 Pediatric Adverse Events Terminology A C87087 Intercostal Retractions Intercostal Retractions The marked inward movement of the muscles between the ribs during inhalation, indicating that there is reduced pressure in the thoracic cavity, and which can be a sign of breathing difficulties. The marked inward movement of the muscles between the ribs during inhalation, indicating that there is reduced pressure in the thoracic cavity, and which can be a sign of breathing difficulties. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C87111 Poor Feeding Poor Feeding Occurs either when an infant shows no interest in feeding or when there is an inability to take in adequate nutrition. Poor feeding is a nonspecific symptom of many disorders, including neurological, genetic, structural, metabolic, and infectious diseases. A non-specific symptom characterized by inadequate oral nutritional intake that may be associated with several different disorders. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C90501 Labored Breathing Labored Breathing Breathing that requires observed effort or an increased amount of energy. Breathing that requires observed effort or an increased amount of energy. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C9438 Chronic Renal Failure Chronic Renal Failure Impairment of the renal function due to chronic kidney damage. Impairment of the renal function due to chronic kidney damage. C3149 Kidney Disease C118464 Pediatric Adverse Events Terminology A C94475 Retching Retching Involuntary spasms of the stomach and esophagus resulting in vomiting or dry heaving. Involuntary spasms of the stomach and esophagus resulting in vomiting or dry heaving. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C96218 Skin Eschar Skin Eschar A crust that covers necrotic tissue in the skin that is caused by a burn or gangrene. A crust that covers necrotic tissue in the skin that is caused by a burn or gangrene. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology A C98950 Hyperammonemia Hyperammonemia Elevated Ammonia Level A laboratory test result demonstrating an increased concentration of ammonia in the blood. A laboratory test result demonstrating an increased concentration of ammonia in the blood. C27120 Electrolyte Disorder C118464 Pediatric Adverse Events Terminology A C99024 Premature Closure of the Ductus Arteriosus Premature Closure of the Ductus Arteriosus Closure of the ductus arteriosus prior to birth. Closure of the ductus arteriosus prior to birth. C35729 Congenital Cardiovascular Abnormality C99137 Great Vessel Abnormality C118464 Pediatric Adverse Events Terminology A C99047 Retinopathy of Prematurity Stage 1 Demarcation Line Retinopathy of Prematurity Stage 1 An ophthalmoscopic finding that refers to retinopathy of prematurity characterized by the presence of a faint demarcation line. A vasoproliferative condition of the retina seen in very immature newborn infants. Stage 1 is defined by a demarcation line, a thin but definite structure that separates the avascular retina anteriorly from the vascularized retina posteriorly. There is abnormal branching or arcading of vessels leading up to the demarcation line that is relatively flat, white, and lies within the plane of the retina. C34982 Retinopathy of Prematurity C118464 Pediatric Adverse Events Terminology A C99048 Retinopathy of Prematurity Stage 2 Intraretinal Ridge Retinopathy of Prematurity Stage 2 An ophthalmoscopic finding that references retinopathy of prematurity characterized by the presence of an elevated ridge. A vasoproliferative condition of the retina seen in very immature newborn infants. Stage 2 is defined by an intraretinal ridge, the ridge arises from the demarcation line and has height and width, which extends above the plane of the retina. The ridge may change from white to pink and vessels may leave the plane of the retina posterior to the ridge to enter it. C34982 Retinopathy of Prematurity C118464 Pediatric Adverse Events Terminology A C99049 Retinopathy of Prematurity Stage 3 Ridge with Extraretinal Fibroblastic Proliferation Retinopathy of Prematurity Stage 3 An ophthalmoscopic finding that references retinopathy of prematurity characterized by the presence of extraretinal fibrovascular tissue. A vasoproliferative condition of the retina seen in very immature newborn infants. Stage 3 is defined by a ridge with extraretinal fibrovascular proliferation, the neovascularization extends from the ridge into the vitreous. This extraretinal proliferating tissue is continuous with the posterior aspect of the ridge, causing a ragged appearance as the proliferation becomes more extensive. C34982 Retinopathy of Prematurity C118464 Pediatric Adverse Events Terminology A C99050 Retinopathy of Prematurity Stage 4 Subtotal Retinal Detachment Retinopathy of Prematurity Stage 4 An ophthalmoscopic finding that references retinopathy of prematurity characterized by the presence of subtotal retinal detachment. A vasoproliferative condition of the retina seen in very immature newborn infants. Stage 4 is defined by subtotal retinal detachment. The retinal detachments are generally concave and most are circumferentially oriented. Retinal detachments usually begin at the point of fibrovascular attachment to the vascularized retina and the extent of detachment depends on the amount of neovascularization present. Stage 4A is defined by retinal detachment which spares the macula. Stage 4B is defined by retinal detachment involving the macula. C34982 Retinopathy of Prematurity C118464 Pediatric Adverse Events Terminology A C99051 Retinopathy of Prematurity Stage 5 Total Retinal Detachment Retinopathy of Prematurity Stage 5 An ophthalmoscopic finding that references retinopathy of prematurity characterized by the presence of total retinal detachment. A vasoproliferative condition of the retina seen in very immature newborn infants. Stage 5 is defined by total retinal detachment. The retinal detachments are generally tractional and usually funnel shaped. The configuration of the funnel itself is used for subdivision of this stage depending if the anterior and posterior portions are open or narrowed. C34982 Retinopathy of Prematurity C118464 Pediatric Adverse Events Terminology A C99059 Short Bowel Syndrome Short Bowel Syndrome Malabsorption that results from the removal of a large segment of the small intestine or, less frequently, from the complete dysfunction of a large portion of the small intestine. Signs and symptoms include diarrhea, steatorrhea, and weigh loss. Malabsorption that results from the removal of a large segment of the small intestine or, less frequently, from the complete dysfunction of a large portion of the small intestine. Signs and symptoms include diarrhea, steatorrhea, and weigh loss. C97171 Congenital Abnormality of the Digestive System C118464 Pediatric Adverse Events Terminology C C50464 Arthralgia Arthralgia Joint Pain Pain in a joint. Pain in a joint. C3303 Pain C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology C C26682 Abdominal Pain Abdominal Pain Painful sensation in the abdominal region. Discomfort in the central region of the body located between the chest and the groin. C3368 Gastrointestinal System Signs and Symptoms C3303 Pain C118464 Pediatric Adverse Events Terminology C C35145 Appendicitis Appendicitis Acute inflammation of the vermiform appendix. Inflammation of the vermiform appendix. C2990 Gastrointestinal Disorder C26726 Infectious Disorder C118464 Pediatric Adverse Events Terminology C C3426 Ulcer Ulcer Ulceration A circumscribed inflammatory and often suppurating lesion on the skin or an internal mucous surface resulting in necrosis of tissue. A circumscribed loss of integrity of the skin or mucous membrane. C36281 Integumentary System Finding C118464 Pediatric Adverse Events Terminology C C117250 Hypomanic Mood Hypomanic Mood An emotional state characterized by mild to moderate elevation of mood without relevant effect of functioning. An emotional state characterized by mild to moderate elevation of mood without relevant effect on functioning. C3858 Mental and Behavioral Signs and Symptoms C118464 Pediatric Adverse Events Terminology C C117253 Disinhibition Disinhibited Disinhibition Unrestrained behavior, often at odds with social norms. Unrestrained behavior, often at odds with social norms. C3858 Mental and Behavioral Signs and Symptoms C118464 Pediatric Adverse Events Terminology C C117261 Oppositional Behavior Oppositionality Oppositional Behavior Negative, defiant, or hostile behavior directed towards authority. Negative, defiant, or hostile behavior directed towards authority. C3858 Mental and Behavioral Signs and Symptoms C118464 Pediatric Adverse Events Terminology C C118189 Hypersexualism Hypersexualism Excessive sexual behavior. Excessive sexual behavior. C3858 Mental and Behavioral Signs and Symptoms C118464 Pediatric Adverse Events Terminology C C118201 Cutting Behavior Cutting Behavior Self-injury caused by making cuts into the skin. Self-injury caused by making cuts into the skin. C3858 Mental and Behavioral Signs and Symptoms C118464 Pediatric Adverse Events Terminology C C118206 Self-Injury Self-Injury Self-Harm Self-inflicted harm without the intent to die. Self-inflicted harm without the intent to die. C3858 Mental and Behavioral Signs and Symptoms C118464 Pediatric Adverse Events Terminology C C26940 Chronic Pain Chronic Pain A longstanding unpleasant sensation associated with real or perceived physical or mental trauma. A longstanding unpleasant sensation. C3303 Pain C118464 Pediatric Adverse Events Terminology C C3394 Suicide Suicide The act of ending one's own life. Death caused by intentionally inflicted self harm. C3858 Mental and Behavioral Signs and Symptoms C118464 Pediatric Adverse Events Terminology C C34706 Hyperactivity Hyperactivity Increased motor activity that is not goal directed. Increased motor activity that is not goal directed. C3858 Mental and Behavioral Signs and Symptoms C118464 Pediatric Adverse Events Terminology C C40122 Pelvic Pain Pelvic Pain Painful sensation in the pelvis. Pain in the pelvic region. C3303 Pain C118464 Pediatric Adverse Events Terminology C C41830 Back Pain Back Pain Painful sensation in the back region. Pain localized to the back. C3303 Pain C118464 Pediatric Adverse Events Terminology C C78223 Breast Pain Breast Pain Painful sensation in the breast region. Pain localized to the breast. C3303 Pain C118464 Pediatric Adverse Events Terminology C C78238 Chest Wall Pain Musculoskeletal Chest Pain Painful sensation in the chest wall region. Pain that originates in the bones, muscles, tendons, or ligaments in the chest. C3303 Pain C118464 Pediatric Adverse Events Terminology C C80111 Suicide Attempt Suicide Attempt Self-inflicted harm in an attempt to end one's own life. Self-inflicted harm with the intent to end one's own life. C3858 Mental and Behavioral Signs and Symptoms C118464 Pediatric Adverse Events Terminology C C93213 Impulsive Behavior Impulsivity Initiation of actions without forethought as to the cost, results or consequences. Behavior characterized by reduced control, planning, or consideration of the consequences. C3858 Mental and Behavioral Signs and Symptoms C118464 Pediatric Adverse Events Terminology C C94241 Compulsion Compulsive Behavior A series of actions or ritualistic behavior that is difficult to suppress and is performed to relieve or prevent anxiety. A series of actions or ritualistic physical or mental behavior that is difficult to suppress and is performed to relieve or prevent anxiety. C3858 Mental and Behavioral Signs and Symptoms C118464 Pediatric Adverse Events Terminology C C50791 Urinary Tract Infection Urinary Tract Infection UTI A bacterial infectious process affecting any part of the urinary tract, most commonly the bladder and the urethra. Symptoms include urinary urgency and frequency, burning sensation during urination, lower abdominal discomfort, and cloudy urine. An infection affecting one or more parts of the urinary tract. C26726 Infectious Disorder C3430 Urinary System Disorder C118464 Pediatric Adverse Events Terminology C C102977 Meconium Peritonitis Meconium Peritonitis Inflammation of the peritoneum caused by an intrauterine intestinal perforation leading to presence of meconium within the fetal peritoneal cavity. This is frequently seen as intra-abdominal calcifications on imaging. Inflammation of the peritoneum caused by an intrauterine intestinal perforation leading to presence of meconium within the fetal peritoneal cavity. This is frequently seen as intra-abdominal calcifications on imaging. C26726 Infectious Disorder C118464 Pediatric Adverse Events Terminology C C112181 Tinea Infection Tinea A skin infection caused by a fungus. A skin infection caused by a fungus. C26726 Infectious Disorder C3371 Integumentary System Disorder C118464 Pediatric Adverse Events Terminology C C112214 Onychomycosis Onychomycosis Tinea Unguium Fungal infection of a fingernail or toenail. Fungal infection of a fingernail or toenail. C26726 Infectious Disorder C3371 Integumentary System Disorder C118464 Pediatric Adverse Events Terminology C C115164 Nosocomial Infection Nosocomial Infection An infection acquired in a hospital or other healthcare setting. An infection acquired in a hospital or other healthcare setting. C26726 Infectious Disorder C118464 Pediatric Adverse Events Terminology C C26686 Abscess Abscess An inflammatory process characterized by the accumulation of pus within a newly formed tissue cavity which is the result of a bacterial, fungal, or parasitic infection or the presence of a foreign body. The accumulation of pus and necrotic material that is separated from the surrounding tissue by a fibrous capsule. C26726 Infectious Disorder C118464 Pediatric Adverse Events Terminology C C3108 HIV Infection HIV Infection An infection caused by the human immunodeficiency virus. Infection caused by the human immunodeficiency virus. C26726 Infectious Disorder C118464 Pediatric Adverse Events Terminology C C35024 Sinusitis Sinusitis An acute or chronic inflammatory process affecting the mucous membranes of any sinus cavity. Inflammation of the mucous membranes lining a sinus cavity. C26726 Infectious Disorder C118420 Otolaryngologic Disorder C118464 Pediatric Adverse Events Terminology C C35050 Surgical Wound Infection Surgical Wound Infection Infection of a surgical incision. Infection of a surgical incision. C26726 Infectious Disorder C118464 Pediatric Adverse Events Terminology C C45234 Wound Infection Wound Infection Infection of a break in the skin or other tissue. Infection of a break in the skin or other tissue due to injury. C26726 Infectious Disorder C118464 Pediatric Adverse Events Terminology C C78599 Infectious Rhinitis Infectious Rhinitis Non-Allergic Rhinitis An inflammatory process affecting the nasal mucosa, usually caused by viruses (e.g., rhinovirus, adenovirus, parainfluenza virus, and coronavirus). It is characterized by chills, headaches, mucopurulent nasal discharge, coughing, and facial pain. Inflammation of the mucous membrane lining the nose due to infection. C26726 Infectious Disorder C118464 Pediatric Adverse Events Terminology C C112858 Early Pregnancy Loss Early Pregnancy Loss Pregnancy loss before 10th week of gestation with documentation of a confirmed pregnancy. Pregnancy loss before 10th week of gestation. C90491 Pregnancy Outcome C118464 Pediatric Adverse Events Terminology C C111908 Angiotensin Converting Enzyme Inhibitor Fetopathy Angiotensin Converting Enzyme Inhibitor Fetopathy ACE Fetopathy Fetal embryopathy associated with maternal angiotensis converting enzyme (ACE) inhibitor use during pregnancy that may include fetal acute renal failure, growth restriction, oligohydramnios, calvaria abnormalities, preterm birth, and pulmonary hypoplasia with respiratory distress. Fetal embryopathy associated with maternal ACE inhibitor use that may include growth restriction, oligohydramnios, calvaria abnormalities, preterm birth, pulmonary hypoplasia and acute kidney injury. C92719 Fetal Disorder C118464 Pediatric Adverse Events Terminology C C111910 Fetal Virilization Fetal Virilization Fetal Virilism Inappropriate secondary sex characteristics in the neonate usually due to in utero androgen exposure. The development of male secondary sexual characteristics in a biologically female fetus that is most often due to in utero exposure to androgens. C92711 Fetal Finding C79859 Virilization C118464 Pediatric Adverse Events Terminology C C112116 Eosinophilic Fasciitis Eosinophilic Fasciitis Inflammation and induration of the fascia related to an accumulation of white blood cells, including eosinophils. An inflammatory disease of the fascia caused by infiltration of eosinophils, which manifests as progressive thickening of the tissues, often with accompanying erythema, pain, and induration. A classic finding is eosinophilia in the peripheral blood. C3371 Integumentary System Disorder C118464 Pediatric Adverse Events Terminology C C113343 Galactorrhea Nipple Discharge Galactorrhea Excessive secretion of breast milk. Abnormal milky discharge from the nipple. C36285 Endocrine System Finding C118464 Pediatric Adverse Events Terminology C C113381 Antepartum Stillbirth Antepartum Stillbirth Fetal death greater than or equal to 20 weeks of gestation prior to labor with Apgar scores of 0 at 1 minute, 5 minutes and beyond. Fetal death greater than or equal to 20 weeks of gestation prior to labor with Apgar scores of 0 at 1 minute, 5 minutes and beyond. C34941 Pregnancy Complication C118464 Pediatric Adverse Events Terminology C C113382 Intrapartum Stillbirth Intrapartum Stillbirth Fetal death greater than or equal to 20 weeks of gestation during labor with Apgar scores of 0 at 1 minute, 5 minutes and beyond. Fetal death greater than or equal to 20 weeks of gestation during labor with Apgar scores of 0 at 1 minute, 5 minutes and beyond. C90491 Pregnancy Outcome C118464 Pediatric Adverse Events Terminology C C113481 Infantile Colic Infantile Colic Infant Colic Paroxysms of irritability, fussing or crying that starts and stops without obvious cause in an infant up to four months of age without failure to thrive. Episodes last three or more hours per day for at least three days per week for at least on week. Consistent pattern of crying in a healthy infant between 3 weeks and 3 months of age. Often defined as lasting 3 hours a day more than 3 days a week for at least 3 weeks in a row. C2990 Gastrointestinal Disorder C118464 Pediatric Adverse Events Terminology C C113768 Direct Hyperbilirubinemia Direct Hyperbilirubinemia Conjugated Hyperbilirubinemia Abnormally high level of conjugated bilirubin in the blood. Abnormally high level of conjugated bilirubin in the blood. C27088 Hyperbilirubinemia C118464 Pediatric Adverse Events Terminology C C113785 Indirect Hyperbilirubinemia Indirect Hyperbilirubinemia Unconjugated Hyperbilirubinemia Abnormally high level of unconjugated bilirubin in the blood. Abnormally high level of unconjugated bilirubin in the blood. C27088 Hyperbilirubinemia C118464 Pediatric Adverse Events Terminology C C114281 Parotitis Parotitis Inflammation of the parotid glands. Inflammation of the parotid glands. C118420 Otolaryngologic Disorder C118464 Pediatric Adverse Events Terminology C C114347 Juvenile Spondyloarthritis Juvenile Spondyloarthritis A group of chronic, inflammatory childhood diseases characterized by arthritis and enthesitis. This disorder can affect the axial skeleton in late childhood or young adulthood. Onset of spondyloarthritis before 18 years of age, and less commonly associated with axial disease. Encompasses the juvenile idiopathic arthritis categories of enthesitis-related arthritis and psoriatic arthritis, and includes many cases of undifferentiated arthritis. C2889 Autoimmune Disease C118464 Pediatric Adverse Events Terminology C C114354 Drug Induced Lupus Erythematosus Drug-Induced Lupus An autoimmune disorder, similar to systemic lupus erythematosus, that is caused by certain drugs. A lupus-like condition which occurs after exposure to a specific pharmacologic agent and typically resolves after discontinuation of the agent. C3507 Immune System Disorder C118464 Pediatric Adverse Events Terminology C C114357 Juvenile Idiopathic Arthritis Juvenile Idiopathic Arthritis A group of chronic, inflammatory childhood disorders of unknown etiology that primarily involve joints. An umbrella term for arthritis of unknown etiology that begins before the sixteenth birthday, and persists for at least six weeks; other known conditions are excluded. Categories include: systemic, oligoarticular, polyarticular rheumatoid factor positive, polyarticular rheumatoid factor negative, psoriatic, enthesitis-related, or undifferentiated. C2889 Autoimmune Disease C118464 Pediatric Adverse Events Terminology C C114471 Macrophage Activation Syndrome Macrophage Activation Syndrome A complication of rheumatic disease that is caused by excessive activation and uncontrolled proliferation of T lymphocytes and well-differentiated macrophages. It is characterized by fever, pancytopenia, liver insufficiency, coagulopathy and neurologic symptoms. A potentially fatal complication of rheumatic disease characterized by fever, pancytopenia, hemophagocytosis, hyperferritinemia, liver insufficiency, coagulopathy and neurologic symptoms. C3507 Immune System Disorder C118464 Pediatric Adverse Events Terminology C C114870 Post-Natal Death at 16-20 Weeks Gestation Post-Natal Death at 16-20 Weeks Gestation A fetus of 16-20 weeks gestational age that shows signs of life at birth but dies after delivery. A fetus of 16-20 weeks gestational age that shows signs of life at birth but dies after delivery. C80082 Neonatal Death C118464 Pediatric Adverse Events Terminology C C116008 Omphalitis Omphalitis Inflammation of the umbilical cord stump in newborns. Inflammation of the umbilical cord stump in newborns. C98996 Neonatal Disorder C118464 Pediatric Adverse Events Terminology C C116364 Auditory Neuropathy Spectrum Disorder Auditory Neuropathy Spectrum Disorder Auditory Neuropathy A hearing disorder characterized by impaired transmission of signals through the auditory nerve, resulting in mild to severe hearing loss and poor speech perception. A group of hearing disorders characterized by impaired transmission of signal through the auditory nerve with abnormal or absent auditory brainstem response with hearing loss and poor speech perception. C63711 Sensory Disorder C118464 Pediatric Adverse Events Terminology C C116384 Post-Inflammatory Hydrocephalus Post-Inflammatory Hydrocephalus An abnormal accumulation of cerebrospinal fluid within the ventricles of the brain that occurs as a consequence of a central nervous system inflammation. An abnormal accumulation of cerebrospinal fluid within the ventricles of the brain that occurs as a consequence of central nervous system infection and/or inflammation. C3111 Hydrocephalus C118464 Pediatric Adverse Events Terminology C C116708 Floppy Infant Floppy Infant Floppy Infant Syndrome|Infantile Hypotonia A syndrome of generalized poor muscle tone and muscle weakness presenting in a newborn infant. A condition characterized by poor muscle tone affecting the craniofacial musculature, trunk and limbs that is due to central or peripheral nervous system abnormalities, myopathies, metabolic disorders, endocrine disorders, and acute or chronic illness, which is usually evident at birth or is identified during early life. C98996 Neonatal Disorder C118464 Pediatric Adverse Events Terminology C C116723 Erb's Palsy Erb's Palsy Weakness or paralysis of muscles in the arm due to damage in the upper brachial plexus. A condition characterized by reduced or absent movement of the ipsilateral shoulder or arm as a consequence of an injury to cervical roots 5, 6 and sometimes 7, also known as the upper brachial plexus. C103231 Brachial Plexus Injury C118464 Pediatric Adverse Events Terminology C C116724 Klumpke Palsy Klumpke's Palsy Weakness or paralysis of muscles in the forearm or hand due to damage of the lower brachial plexus. A condition characterized by reduced or absent movement of the ipsilateral hand as a consequence of an injury to cervical root 8 and thoracic root 1, also known as the lower brachial plexus. C103231 Brachial Plexus Injury C118464 Pediatric Adverse Events Terminology C C118240 Periodic Fever Syndrome Autoinflammatory Syndrome Periodic Fever Syndrome Fevers of unknown etiology recurring over months or years. An umbrella term for disorders characterized by persistent, episodic fevers with variable clinical manifestations. They do not have an infectious etiology and lack autoantibodies or autoreactive T cells. Some are autoinflammatory in origin. C9229 Systemic Disorder C118464 Pediatric Adverse Events Terminology C C118316 Mucosal Ulcer Mucosal Ulcer A circumscribed loss of integrity of the mucous membrane. A circumscribed loss of integrity of the mucous membrane. C3426 Ulcer C118464 Pediatric Adverse Events Terminology C C26739 Sensorineural Hearing Loss Sensorineural Hearing Loss Hearing loss resulting from damage to the cochlea, auditory nerve and/or brainstem. Hearing loss resulting from damage to the cochlea, auditory nerve and/or brainstem. C35731 Hearing Loss C118464 Pediatric Adverse Events Terminology C C26860 Pleuritis Pleuritis Inflammation of the pleura. It is usually caused by infections. Chest pain while breathing or coughing is the presenting symptom. Inflammation of the pleura. C26871 Respiratory System Disorder C118464 Pediatric Adverse Events Terminology C C26909 Uveitis Uveitis An inflammatory process affecting a part of or the entire uvea. Causes include inflammatory agents (e.g., herpes simplex, herpes zoster, leptospirosis) and systemic diseases (e.g., inflammatory bowel disease, multiple sclerosis, systemic lupus erythematosus, ankylosing spondylitis). Patients present with pain and redness in the eye, light sensitivity, and blurred and decreased vision. Inflammation of the iris, ciliary body, and/or choroid (uveal tract). C26767 Eye Disorder C118464 Pediatric Adverse Events Terminology C C27071 Transient Hypogammaglobulinemia of Infancy Transient Hypogammaglobulinemia of Infancy A rare, primary humoral immunodeficiency of childhood characterized by decreasing serum levels of immunoglobulin G (IgG) as maternal antibodies clear the circulation while serum levels of immunoglobulin A and immunoglobulin M remain normal or are slightly decreased. Diagnosis may be suspected after the age of six months when a child's own synthesis of IgG should accelerate but it must be confirmed retrospectively after normalization of all serum immunoglobulin levels is seen by ages 2-6. This disorder may be caused by inadequate activation of progenitor B cells, defective class-switching or may even represent a maturational variant. Typically, a normal response to protein antigens is found while there is a notably diminished response to viral and bacterial polysaccharide antigens. Clinical presentation may include recurrent infections especially those of the respiratory tract. Despite increased susceptibility to infection in childhood, this disorder is self-limited with minimal implications for a normal life span. Transitory decrease in the concentration of IgG below established reference ranges, in an infant or child less than 6 months of age. IgA and IgM concentrations may be decreased as well. C3507 Immune System Disorder C118464 Pediatric Adverse Events Terminology C C27560 Respiratory Distress Syndrome Respiratory Distress Syndrome A condition beginning in the first day of life that results from inadequate surfactant production, causing increased work of breathing and impaired gas exchange. Progressive alveolar atelectasis from birth due to an abnormality of synthesis, function or metabolism of surfactant, characterized by respiratory failure and an abnormal chest radiograph showing diffuse reticulogranular densities and air bronchograms. C97173 Congenital Abnormality of the Respiratory System C99232 Neonatal Respiratory System Disorder C118464 Pediatric Adverse Events Terminology C C27576 Childhood Dermatomyositis Juvenile Dermatomyositis An inflammatory myopathy of childhood resulting in muscle weakness, and associated with a characteristic skin rash. An inflammatory myopathy of childhood resulting in symmetric proximal muscle weakness, and associated with characteristic cutaneous findings, such as heliotrope rash or Gottron's papules. C2889 Autoimmune Disease C118464 Pediatric Adverse Events Terminology C C2881 Arrhythmia Arrhythmia Any variation from the normal rate or rhythm (which may include the origin of the impulse and/or its subsequent propagation) in the heart. Any variation from the normal rate or rhythm (which may include the origin of the impulse and/or its subsequent propagation) in the heart. C78245 Cardiac Conduction Disorder C118464 Pediatric Adverse Events Terminology C C2883 Arthritis Arthritis An inflammatory process affecting a joint. Causes include infection, autoimmune processes, degenerative processes, and trauma. Signs and symptoms may include swelling around the affected joint and pain. Inflammation of the joint tissues of any etiology. Signs and symptoms may include pain, swelling, warmth, guarding, limited range of motion or overlying erythema. C107377 Musculoskeletal System Disorder C118464 Pediatric Adverse Events Terminology C C3090 Hematuria Hematuria Blood in the urine. The presence of red blood cells in the urine. C3149 Kidney Disease C118464 Pediatric Adverse Events Terminology C C34399 Arteritis Arteritis An inflammatory process affecting an artery. Inflammation of an artery. C35117 Vascular Disorder C118464 Pediatric Adverse Events Terminology C C34460 Cerebral Palsy Cerebral Palsy A group of disorders affecting the development of movement and posture, often accompanied by disturbances of sensation, perception, cognition, and behavior. It results from damage to the fetal or infant brain. A non-progressive, neurological syndrome presenting in infancy or early childhood that is caused by brain injury or malformation and is characterized by permanent impairment of muscle coordination and various movement disorders. C26835 Neurologic Disorder C89328 Pediatric Disease or Disorder C118464 Pediatric Adverse Events Terminology C C34831 Myocarditis Myocarditis Inflammation of the muscle tissue of the heart. Inflammation of the myocardium. C3079 Heart Disease C118464 Pediatric Adverse Events Terminology C C34915 Pericarditis Pericarditis An inflammatory process affecting the pericardium. Inflammation of the pericardium, frequently manifested as chest pain, friction rub, pericardial effusion, or ST segment elevation on EKG. C101327 Pericardial Anomaly C118464 Pediatric Adverse Events Terminology C C34963 Henoch-Schonlein Purpura Henoch-Schonlein Purpura A systemic, usually self-limited immune complex vasculitis, characterized by immunoglobulin A deposition in the small vessels and kidneys. It is manifested with small hemorrhages in the skin, gastrointestinal symptoms, arthritis, and nephropathy. A systemic, usually self-limited immune complex vasculitis, characterized by immunoglobulin A deposition in the small vessels and kidneys. It is manifested with small hemorrhages in the skin, gastrointestinal symptoms, arthritis, and nephropathy. C2931 Cardiovascular Disorder C118464 Pediatric Adverse Events Terminology C C34982 Retinopathy of Prematurity Retinopathy of Prematurity A bilateral retinopathy characterized by neovascularization, scarring, retinal detachment, and eventually blindness. It may be mild or severe. It occurs in babies born prematurely. Causes include oxygen toxicity and hypoxia. A retinal condition of very immature infants that may be characterized by non-vascularized retina that may lead to neovascularization, scarring, retinal detachment, and blindness. C98996 Neonatal Disorder C62601 Retinopathy C118464 Pediatric Adverse Events Terminology C C35109 Anterior Uveitis Anterior Uveitis Iridocyclitis|Iritis Inflammation of the iris and anterior chamber of the eye. Inflammation of the anterior uveal tract. C26909 Uveitis C118464 Pediatric Adverse Events Terminology C C35111 Posterior Uveitis Posterior Uveitis An inflammatory process that affects the choroid. Inflammation of the posterior uveal tract. C26909 Uveitis C118464 Pediatric Adverse Events Terminology C C38012 Proteinuria Proteinuria The presence of excessive protein, chiefly albumin but also globulin, in the urine. The presence of excessive protein in the urine. C36292 Laboratory Test Result C118464 Pediatric Adverse Events Terminology C C39594 Skin Rash Rash Any change in the skin which affects its appearance or texture. A rash may be localized to one part of the body, or affect all the skin. Rashes may cause the skin to change color, itch, become warm, bumpy, dry, cracked or blistered, swell and may be painful. An eruption in the skin which affects its appearance and/or texture. C36281 Integumentary System Finding C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology C C49151 Stillbirth Stillbirth A fetus of at least 20 weeks gestation, or of a birth weight of at least 350 grams if the gestational age is unknown, that is born without signs of life at the time of delivery, and with an Apgar score of zero at both one and five minutes. A fetus of at least 20 weeks gestation, or of a birth weight of 350 grams or greater when the gestational age is not known, with no signs of life at the time of delivery, with Apgar scores of 0 at 1 and 5 minutes. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology C C49343 Deep Vein Thrombosis Deep Venous Thrombosis A blood clot in a deep vein, predominantly in the lower extremity, but may include the pelvis or upper extremity. Formation of a blood clot within a deep vein. C99107 Venous Thrombosis C118464 Pediatric Adverse Events Terminology C C50563 Fetal Distress Nonreassuring Fetal Status Fetal Distress|Fetal Intolerance of Labor Signs or symptoms which may be indicative of distress to a fetus, which may include repetitive variable decelerations, fetal tachycardia or bradycardia, late decelerations, or low biophysical profile. Signs or symptoms which may be indicative of distress to a fetus, which may include repetitive variable decelerations, fetal tachycardia or bradycardia, late decelerations, or low biophysical profile. C81236 Birth Complication C92711 Fetal Finding C118464 Pediatric Adverse Events Terminology C C50685 Pallor Pallor An unusual or extreme paleness, state of decreased skin or mucosal coloration. A condition characterized by an abnormal loss of color to the skin or mucous membranes due to reduced delivery of saturated hemoglobin. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology C C72069 Localized Scleroderma Morphea Localized Scleroderma A chronic disorder, possibly autoimmune, marked by excessive production of collagen which results in hardening and thickening of body tissues. Localized scleroderma typically affects the skin, with formation of patches or lines of thick and unyielding tissue; there can be muscle and underlying tissue involvement as well as occasional joint complications. The affected areas of skin can be restrictive and disfiguring. The shape, depth and location of the affected area is used to classify one of the four types of local scleroderma. An individual can have a combination of localized scleroderma types. An autoimmune disorder marked by excessive production of collagen resulting in hardening and thickening of skin, with formation of patches or lines of thick and unyielding tissue. There can also be musculoskeletal and underlying tissue involvement. The affected areas of skin can be restrictive and disfiguring. C26746 Scleroderma C118464 Pediatric Adverse Events Terminology C C78610 Skin Hypopigmentation Hypopigmentation Pigment Dilution Abnormal lightening of skin due to decreased melanin production or deposition. Vitiligo, albinism, and leukoderma are among the disorders that are associated with skin hypopigmentation. A condition characterized by an abnormal loss of color to the skin due to the depletion of melanocytes or melanin. C36281 Integumentary System Finding C118464 Pediatric Adverse Events Terminology C C78787 Purpura Purpura A small blood vessel hemorrhage into the skin and/or mucous membranes. Newer lesions appear reddish in color. Older lesions are usually a darker purple color and eventually become a brownish-yellow color. Small blood vessel hemorrhage into the skin and/or mucous membranes presenting as red or purplish patches. C36281 Integumentary System Finding C118464 Pediatric Adverse Events Terminology C C84799 Kernicterus Kernicterus A rare neurologic disorder occurring in infants with jaundice. It results from brain damage by existing high levels of unconjugated-indirect bilirubin. A condition characterized by sensorineural hearing impairment, choreoathetoid movements, paralysis of upward gaze and hypoplasia of dental enamel due bilirubin deposition in the grey matter of the central nervous system as a consequence of increased levels of unconjugated bilirubin in the serum. C26920 Encephalopathy C118464 Pediatric Adverse Events Terminology C C84915 Necrotizing Enterocolitis Necrotizing Enterocolitis A fulminating disease of neonates in which there is extensive mucosal ulceration, pseudomembrane formation, submucosal hemorrhage, and necrosis usually of the right colon, cecum, terminal ileum, and appendix, possibly due to perinatal intestinal ischemia and bacterial invasion. Progression can lead to necrosis, perforation and/or scarring of the intestinal tract. A disease of neonates in which there is extensive mucosal ulceration, pseudomembrane formation, submucosal hemorrhage, and necrosis. C98996 Neonatal Disorder C118464 Pediatric Adverse Events Terminology C C84978 Osteochondrodysplasia Skeletal Dysplasia A term referring to disorders characterized by abnormalities in the development of bones and cartilage. A complex group of bone and cartilage disorders that result in abnormalities in the size and shape of the trunk, extremities, and/or skull. C89337 Congenital Musculoskeletal Defect C118464 Pediatric Adverse Events Terminology C C84989 Panuveitis Panuveitis A disorder characterized by inflammation of the entire uvea which includes the iris, ciliary body, and choroid. Causes include systemic infections, sarcoidosis, and cancers. Inflammation of all layers of the uvea. C26909 Uveitis C118464 Pediatric Adverse Events Terminology C C87070 Hypotonia Hypotonia A condition of decreased tone of the skeletal muscles and diminished resistance to passive stretching. Abnormally low muscle tone. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology C C87085 Hypertonia Hypertonia A condition of increased muscle tone manifested by increased resistance of the muscle to passive stretching. Abnormally high muscle tone. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology C C87095 Mottling Skin Mottling Mottling Irregularly shaped, patchy discolorations in the skin. Irregularly shaped and discolored patches on the skin. C36281 Integumentary System Finding C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology C C92839 Oligohydramnios Oligohydramnios A lower than normal quantity of amniotic fluid in the amniotic sac as compared to normal values. Typically associated with an amniotic fluid index (AFI) of less than 5 cm or a single maximum vertical pocket (MVP) of less than 2 cm. A lower than normal quantity of amniotic fluid in the amniotic sac. Typically associated with an amniotic fluid index (AFI) of less than 5 cm or a single maximum vertical pocket (MVP) of less than 2 cm. C92719 Fetal Disorder C34941 Pregnancy Complication C118464 Pediatric Adverse Events Terminology C C92848 Polyhydramnios Polyhydramnios An excess quantity of amniotic fluid in the amniotic sac as compared to normal values. Typically associated with an amniotic fluid index (AFI) of greater than or equal to 25 cm or a single maximum vertical pocket (MVP) of greater than 8 cm. An excess quantity of amniotic fluid in the amniotic sac as compared to normal values. Typically associated with an amniotic fluid index (AFI) of greater than or equal to 25 cm or a single maximum vertical pocket (MVP) of greater than 8 cm. C92719 Fetal Disorder C34941 Pregnancy Complication C118464 Pediatric Adverse Events Terminology C C92866 Recurrent Deceleration Recurrent Fetal Heart Rate Deceleration Fetal heart rate decelerations that occur with greater than or equal to 50 percent of uterine contractions within a 20 minute timeframe. Applies to early, late or variable decelerations. Fetal heart rate decelerations that occur with greater than or equal to 50 percent of uterine contractions within a 20 minute timeframe. Applies to early, late or variable decelerations. C92789 Fetal Heart Rate Deceleration C118464 Pediatric Adverse Events Terminology C C94832 Systemic Inflammatory Response Syndrome Systemic Inflammatory Response Syndrome A generalized state of dysregulated inflammation induced by noninfectious processes. It is characterized by two or more of the following signs and symptoms: fever or hypothermia, increased heart rate, increased respiratory rate, and abnormal white blood cell count. A generalized state of dysregulated inflammation characterized by two or more of the following signs and symptoms: fever or hypothermia, increased heart rate, increased respiratory rate, and abnormal white blood cell count. C9229 Systemic Disorder C118464 Pediatric Adverse Events Terminology C C97077 Funisitis Funisitis An acute inflammation of the umbilical cord. It is characterized by the presence of polymorphonuclear cells migrating from the fetal umbilical cord vessels through the umbilical cord towards the bacteria containing amniotic fluid. A neutrophilic infiltrate arising from fetal vessels of the umbilical cord extending past the umbilical vessel wall into Wharton's Substance and oriented towards the amniotic cavity. C92719 Fetal Disorder C118464 Pediatric Adverse Events Terminology C C98971 Laryngomalacia Laryngomalacia Increased collapsibility of the larynx. An abnormality characterized by softening of the laryngeal cartilage typically presenting with stridor. C97173 Congenital Abnormality of the Respiratory System C118464 Pediatric Adverse Events Terminology C C99013 Periventricular Leukomalacia Periventricular Leukomalacia Necrosis and softening of the white matter around the ventricles in the brain. It is usually seen in preterm infants and caused by lack of blood flow and oxygenation in the periventricular brain parenchyma. A form of cerebral white matter injury usually seen in preterm infants that is characterized by necrotic degeneration or gliosis of white matter adjacent to the cerebral ventricles, that may evolve into focal cysts. C98920 Encephalomalacia C118464 Pediatric Adverse Events Terminology C C99016 Phrenic Nerve Injury Phrenic Nerve Injury Damage to the phrenic nerve. Damage to the phrenic nerve, resulting in paralysis of the ipsilateral hemidiaphragm. C3671 Injury C118464 Pediatric Adverse Events Terminology C C111886 Diaper Dermatitis Diaper Dermatitis Diaper Rash|Nappy Rash An inflammatory skin condition in the diaper area that may be caused by irritation or infection. An inflammatory skin condition in the diaper area that may be caused by irritation or infection. C3371 Integumentary System Disorder C118464 Pediatric Adverse Events Terminology C C118857 Lamellar Laceration of the Globe Lamellar Laceration of the Globe Traumatic injury to the globe, resulting in a partial thickness wound of the eyewall (cornea and/or sclera). (adapted from the Birmingham Eye Trauma Terminology System (BETTS)) Traumatic injury to the globe, resulting in a partial thickness wound of the eyewall (cornea and/or sclera). (adapted from the International Society of Ocular Trauma-Birmingham Eye Trauma Terminology System (BETTS)) C118747 Closed Globe Injury C118464 Pediatric Adverse Events Terminology C C26821 Lymphadenitis Lymphadenitis Acute or chronic inflammation of one or more lymph nodes. It is usually caused by an infectious process. Inflammation of one or more lymph nodes. C3507 Immune System Disorder C118464 Pediatric Adverse Events Terminology C C26884 Sleep Apnea Sleep Apnea Cessation of breathing for short periods during sleep. It is classified as obstructive, central, or mixed obstructive-central. It can occur at any age but it is more frequent in people over forty. Risk factors include male sex and obesity. The cessation of breathing for periods of time during sleep. C26698 Apnea C118464 Pediatric Adverse Events Terminology C C26974 Mixed Hearing Loss Mixed Hearing Loss Hearing loss characterized by a combination of conductive and sensorineural hearing loss. It is caused by problems in both the inner ear and middle or outer ear. A combination of conductive and sensorineural hearing loss. C35731 Hearing Loss C118464 Pediatric Adverse Events Terminology C C3282 Nystagmus Nystagmus Involuntary movements of the eyeballs. The presence or absence of nystagmus is often used in the diagnosis of a variety of neurological and visual disorders. Repetitive and involuntary movement of the eyes. C99208 Eye Finding C118464 Pediatric Adverse Events Terminology C C43245 Pyramidal Tract Dysfunction Pyramidal Tract Syndrome Dysfunction of the corticospinal (pyramidal) tracts of the spinal cord. Symptoms include increased muscle tone in the lower extremities, hyperreflexia, positive Babinski, and decreased fine motor coordination. Dysfunction of the corticospinal tracts of the spinal cord. C2934 Central Nervous System Disorder C118464 Pediatric Adverse Events Terminology C C4781 Benign Brain Neoplasm Benign Brain Tumor A primary, slow growing, noninvasive neoplasm of the brain. In children, astrocytomas of the cerebellum represent relatively common benign brain neoplasms. In adults meningiomas, neurilemomas and pituitary tumors comprise the majority of benign tumors. An abnormal intracranial solid mass or growth arising within the brain without histologic features suggesting the potential to metastasize. C2907 Brain Tumor C118464 Pediatric Adverse Events Terminology C C79859 Abnormal Virilization Virilization Virilism The abnormal development of male secondary sexual characteristics due to excessive androgens. The abnormal development of male secondary sexual characteristics due to excessive androgens. C36285 Endocrine System Finding C118464 Pediatric Adverse Events Terminology C C111659 Poor Weight Gain Poor Weight Gain Failure to Gain Weight|Inadequate Weight Gain|Low Weight Gain Slower than normal rate of weight increase. Slower than normal rate of weight increase. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology C C111967 Pustular Eruption Pustular Eruption Pustular Lesion A diffuse or generalized outbreak of numerous pustules. A diffuse or generalized outbreak of numerous pustules. C36281 Integumentary System Finding C118464 Pediatric Adverse Events Terminology C C112208 Drug Hypersensitivity Syndrome Drug Reaction with Eosinophilia and Systemic Symptoms DRESS|Drug Hypersensitivity Syndrome A potentially life-threatening hypersensitivity reaction to a pharmacologic substance that is characterized by rash, lymphadenopathy, fever, hematologic abnormalities and involvement of one or more internal organs. A potentially life-threatening hypersensitivity reaction to a pharmacologic substance that is characterized by rash, lymphadenopathy, fever, hematologic abnormalities and involvement of one or more internal organs. C3371 Integumentary System Disorder C118464 Pediatric Adverse Events Terminology C C114698 Oliguria Oliguria Decreased Urine Output Abnormally low urine output. Abnormally low urine output. C36286 Urinary System Finding C118464 Pediatric Adverse Events Terminology C C116310 Apparent Life Threatening Event Apparent Life Threatening Event ALTE An episode during which the patient, usually a child less than one year, experiences a combination of apnea, color change, alteration in muscle tone, choking or gagging. This event can be frightening to the observer. An episode in an infant that is frightening to the observer, and that is characterized by some combination of apnea (central or occasionally obstructive), color change, marked change in muscle tone, choking or gagging. (NIH, 1987) C89328 Pediatric Disease or Disorder C118464 Pediatric Adverse Events Terminology C C118475 Suppurative Arthritis Suppurative Arthritis Pyogenic Arthritis Acute inflammation of one or more joints caused by the presence of pus within the joint cavity. Acute inflammation of one or more joints caused by the presence of pus within the joint cavity. C2883 Arthritis C118464 Pediatric Adverse Events Terminology C C13280 Sweat Sweat Perspiration|Sweats The liquid secreted by the sweat glands, having a salty taste and a pH that varies from 4.5 to 7.5. Sweat produced by the eccrine sweat glands is clear with a faint characteristic odor, and contains water, sodium chloride, and traces of albumin, urea, and other compounds. Its composition varies with many factors, e.g., fluid intake, external temperature and humidity, and some hormonal activity. Sweat produced by the larger, deeper, apocrine sweat glands of the axillae contains, in addition, organic material which on bacterial decomposition produces an offensive odor. The secretion by the sweat glands that is primarily composed of water and salt. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology C C26766 Epistaxis Epistaxis Nose Bleed Bleeding from the nose. Bleeding from the nose. C45233 Respiratory Finding C118464 Pediatric Adverse Events Terminology C C26781 Gastroesophageal Reflux Disease Gastroesophageal Reflux Disease GERD A chronic disorder characterized by reflux of the gastric and/or duodenal contents into the distal esophagus. It is usually caused by incompetence of the lower esophageal sphincter. Symptoms include heartburn and acid indigestion. It may cause injury to the esophageal mucosa. Reflux of stomach contents with symptoms and/or complications from the reflux act. C2990 Gastrointestinal Disorder C118464 Pediatric Adverse Events Terminology C C26791 Hemorrhage Hemorrhage Bleeding The flow of blood from a ruptured blood vessel. Loss of blood. C2931 Cardiovascular Disorder C118464 Pediatric Adverse Events Terminology C C26797 Hyperglycemia Hyperglycemia Elevated Blood Glucose Abnormally high level of glucose in the blood. Abnormally high level of glucose in the blood. C36292 Laboratory Test Result C118464 Pediatric Adverse Events Terminology C C2851 Acquired Immunodeficiency Syndrome Acquired Immunodeficiency Disease AIDS A syndrome resulting from the acquired deficiency of cellular immunity caused by the human immunodeficiency virus (HIV). It is characterized by the reduction of the Helper T-lymphocytes in the peripheral blood and the lymph nodes. Symptoms include generalized lymphadenopathy, fever, weight loss, and chronic diarrhea. Patients with AIDS are especially susceptible to opportunistic infections (usually pneumocystis carinii pneumonia, cytomegalovirus (CMV) infections, tuberculosis, candida infections, and cryptococcosis), and the development of malignant neoplasms (usually non-Hodgkin lymphoma and Kaposi sarcoma). The human immunodeficiency virus is transmitted through sexual contact, sharing of contaminated needles, or transfusion of contaminated blood. A chronic, potentially life threatening condition that is caused by the human immunodeficiency virus (HIV) infection, and is characterized by increased susceptibility to opportunistic infections, certain cancers and neurologic disorders. C9229 Systemic Disorder C118464 Pediatric Adverse Events Terminology C C2980 Dysphagia Dysphagia Difficulty Swallowing A symptom referring to difficulty in swallowing. It may be observed in patients with stroke, motor neuron disorders, cancer of the throat or mouth, head and neck injuries, Parkinson disease, and multiple sclerosis. Difficulty in swallowing. C3368 Gastrointestinal System Signs and Symptoms C118464 Pediatric Adverse Events Terminology C C2987 Diarrhea Diarrhea Frequent Stools|Loose Stools Watery bowel movements. Watery bowel movements. C3368 Gastrointestinal System Signs and Symptoms C118464 Pediatric Adverse Events Terminology C C2992 Disseminated Intravascular Coagulation Disseminated Intravascular Coagulation DIC A pathological process where the blood starts to coagulate throughout the whole body. This depletes the body of its platelets and coagulation factors, and there is an increased risk of hemorrhage. Excessive activation of the body's coagulation system resulting in systemic microvascular thrombi formation. C2902 Coagulopathy C118464 Pediatric Adverse Events Terminology C C3171 Acute Myeloid Leukemia Acute Myeloid Leukemia Acute Granulocytic Leukemia|Acute Megakaryocytic Leukemia|Acute Myelocytic Leukemia|Acute Myelogenous Leukemia A clonal expansion of myeloid blasts in the bone marrow, blood or other tissues. The classification of acute myeloid leukemias (AMLs) encompasses four major categories: 1) AML with recurrent genetic abnormalities; 2) AML with multilineage dysplasia; 3) Therapy-related AML; 4) AML not otherwise categorized. The required bone marrow or peripheral blood blast percentage for the diagnosis of AML is 20% (WHO classification). A rapidly progressive cancer of the blood and bone marrow consisting of the proliferation of abnormal myeloblasts, which are immature, dysfunctional white blood cells. C3161 Leukemia C118464 Pediatric Adverse Events Terminology C C3423 Tuberculosis Tuberculosis TB A chronic, recurrent infection caused by the bacterium Mycobacterium tuberculosis. Tuberculosis (TB) may affect almost any tissue or organ of the body with the lungs being the most common site of infection. The clinical stages of TB are primary or initial infection, latent or dormant infection, and recrudescent or adult-type TB. Ninety to 95% of primary TB infections may go unrecognized. Histopathologically, tissue lesions consist of granulomas which usually undergo central caseation necrosis. Local symptoms of TB vary according to the part affected; acute symptoms include hectic fever, sweats, and emaciation; serious complications include granulomatous erosion of pulmonary bronchi associated with hemoptysis. If untreated, progressive TB may be associated with a high degree of mortality. This infection is frequently observed in immunocompromised individuals with AIDS or a history of illicit IV drug use. A disease caused by Mycobacterium tuberculosis infection that is characterized by the growth of nodules in body tissues, most commonly the lungs, and may be transmitted through droplets from the throat or lungs of individuals with the active respiratory disease. C2890 Bacterial Disease C118464 Pediatric Adverse Events Terminology C C37943 Dizziness Dizziness Lightheadedness A sensation of lightheadedness, unsteadiness, turning, spinning or rocking. A sensation of lightheadedness, unsteadiness, turning, spinning or rocking. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology C C3988 Syndrome of Inappropriate Antidiuretic Hormone Secretion Syndrome of Inappropriate Antidiuretic Hormone SIADH A syndrome characterized by abnormal secretion of antidiuretic hormone in conjunction with neoplastic growth occurring anywhere in the body. A syndrome characterized by abnormally increased secretion of antidiuretic hormone. Signs and symptoms include hyponatremia and hypo-osmolality. C3009 Endocrine System Disorder C118464 Pediatric Adverse Events Terminology C C50767 Tachypnea Tachypnea Fast Breathing Abnormal increase of rate of breathing. An increased rate of respiration. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology C C50845 Skin Erosion Erosion Skin Breakdown|Skin Erosion Tearing or wearing off of skin. Tearing or wearing off of skin. C36281 Integumentary System Finding C118464 Pediatric Adverse Events Terminology C C78416 Lethargy Lethargy Listless Decreased consciousness characterized by mental and physical inertness. A profound lack of mental and physical energy. C100104 Signs or Symptoms C118464 Pediatric Adverse Events Terminology C C78598 Reversible Posterior Leukoencephalopathy Syndrome Posterior Reversible Encephalopathy Syndrome PRES|Reversible Occipital Parietal Encephalopathy|Reversible Posterior Cerebral Edema Syndrome|Reversible Posterior Leukoencephalopathy Syndrome An acute or subacute reversible condition characterized by headaches, mental status changes, visual disturbances, and seizures associated with imaging findings of posterior leukoencephalopathy. It has been observed in association with hypertensive encephalopathy, eclampsia, and immunosuppressive and cytotoxic drug treatment. A neurotoxic state associated with posterior cerebral edema and variable neurological symptoms, typically including seizures, visual disturbance, mental status changes and/or headache. C26920 Encephalopathy C118464 Pediatric Adverse Events Terminology C C85173 Sudden Infant Death Syndrome Sudden Infant Death Syndrome SIDS Unexpected death in infancy which remains unexplained following autopsy, review of the medical history, and investigation of the death circumstances and death scene. The unexpected death of an infant less than 1 year of age that cannot be explained after a thorough investigation is conducted, including a complete autopsy, examination of the death scene, and review of the clinical history. C28554 Death C118464 Pediatric Adverse Events Terminology C C98936 Hematochezia Hematochezia Bloody Stool The passage of fresh blood from the anus. The blood is usually seen in the stools. The most common cause is lower gastrointestinal tract hemorrhage. The presence of fresh blood mixed in the fecal matter; usually as a result of lower gastrointestinal tract hemorrhage. C3368 Gastrointestinal System Signs and Symptoms C118464 Pediatric Adverse Events Terminology C C76131 Second-Degree Burn Second Degree Burn An injury that includes the entire epidermis and upper layers of the dermis due to a chemical, friction, radiation or thermal exposure. The affected area appears as moist red or white skin that does not blanch. Often it is painful with the presence of blisters. A burn that involves the full thickness of the epidermis characterized by blisters. C34441 Burn C118464 Pediatric Adverse Events Terminology C C84919 Nephrogenic Diabetes Insipidus Nephrogenic Diabetes Insipidus Nephrogenic Diabetes Insipidus Diabetes insipidus caused by insensitivity of the kidneys to antidiuretic hormone. Diabetes insipidus caused by insensitivity of the kidneys to antidiuretic hormone. C43263 Diabetes Insipidus C118464 Pediatric Adverse Events Terminology C C99138 Germinal Matrix Hemorrhage of the Newborn Germinal Matrix Hemorrhage of Newborn Intraventricular Hemorrhage of Newborn Grade 1 Bleeding into the thick layer of immature cells under the ependymal lining at the ventrolateral aspect of the lateral cerebral ventricles of a newborn. Bleeding into the thick layer of immature cells under the ependymal lining at the ventrolateral aspect of the lateral cerebral ventricles. C50896 Intraventricular Hemorrhage C98996 Neonatal Disorder C118464 Pediatric Adverse Events Terminology C C115788 Subcapsular Renal Hematoma Subcapsular Hematoma A collection of blood between the renal capsule and the renal parenchyma. A collection of blood between the renal capsule and the renal parenchyma. C50579 Hematoma C118464 Pediatric Adverse Events Terminology D C111944 Histologic Chorioamnionitis Histologic Chorioamnionitis Inflammation of the fetal sac membranes that is characterized by neutrophilic infiltration of the amnion and chorion. A maternal neutrophilic response resulting in migration of neutrophils from the decidua into the chorion and amnion of the extraplacental membranes and the chorionic plate. (Perinatal)|Inflammation of the fetal sac membranes, characterized by neutrophilic infiltration of the amnion and chorion. (AE) C26720 Chorioamnionitis C118464 Pediatric Adverse Events Terminology