C	C35145	Appendicitis	Appendicitis		Acute inflammation of the vermiform appendix.	Inflammation of the vermiform appendix.	C2990	Gastrointestinal Disorder	C26726	Infectious Disorder	C99147	Neonatal Research Network Terminology		
C	C27582	Central Nervous System Infectious Disorder	Central Nervous System Infectious Disease	Infectious Disease of Central Nervous System	An infectious process that affects the brain and/or spinal cord. Representative examples include encephalitis, poliomyelitis, arachnoiditis, and meningitis.		C2934	Central Nervous System Disorder	C26726	Infectious Disorder	C99147	Neonatal Research Network Terminology		
C	C2989	DiGeorge Syndrome	DiGeorge Syndrome	DiGeorge Sequence|Sphrintzen|VCF|Velo-Cardio-Facial Syndrome	A congenital anomaly characterized by immunodeficiency, abnormal facies, congenital heart disease, hypocalcemia, and increased susceptibility to infections. Pathologic characteristics include conotruncal abnormalities and absence or hypoplasia of thymus and parathyroid glands. DiGeorge syndrome is associated with abnormalities of chromosome 22. Also known as DiGeorge anomaly.		C3101	Genetic Disorder			C99147	Neonatal Research Network Terminology		
C	C2991	Disease or Disorder	Disease or Disorder	Disease	Any abnormal condition of the body or mind that causes discomfort, dysfunction, or distress to the person affected or those in contact with the person. The term is often used broadly to include injuries, disabilities, syndromes, symptoms, deviant behaviors, and atypical variations of structure and function.		C90259	Pediatric Terminology			C99147	Neonatal Research Network Terminology		
C	C101312	Immature Retinopathy of Prematurity	Immature Retinopathy of Prematurity	ROP|Retinopathy of Prematurity, Immature	An immature state in which retinopathy of prematurity cannot be established.	Retinopathy of prematurity occurs in premature infants who are born before the retinal vessels complete their normal growth. It can result in disorganized and abnormal growth of retinal blood vessels, which may lead to scarring and retinal detachment.	C34982	Retinopathy of Prematurity			C99147	Neonatal Research Network Terminology		
C	C34571	Interstitial Emphysema	Interstitial Emphysema	Interstitial Emphysema of Lung|PIE|Pulmonary Interstitial Emphysema	Pathologic accumulation of air in the interstitium of the lungs. It is caused by the rupture of alveoli and terminal bronchioles. It is most often seen in premature infants that need mechanical ventilation for respiratory distress syndrome.		C3198	Lung Disorder			C99147	Neonatal Research Network Terminology		
C	C25218	Intervention or Procedure	Intervention or Procedure	Procedure	An activity that produces an effect, or that is intended to alter the course of a disease in a patient or population. This is a general term that encompasses the medical, social, behavioral, and environmental acts that can have preventive, therapeutic, or palliative effects.		C90259	Pediatric Terminology			C99147	Neonatal Research Network Terminology		
C	C84799	Kernicterus	Kernicterus	Bilirubin Encephalopathy	A rare neurologic disorder occurring in infants with jaundice. It results from brain damage by existing high levels of unconjugated-indirect bilirubin.	A condition characterized by sensorineural hearing impairment, choreoathetoid movements, paralysis of upward gaze and hypoplasia of dental enamel due bilirubin deposition in the grey matter of the central nervous system as a consequence of increased levels of unconjugated bilirubin in the serum.	C26920	Encephalopathy			C99147	Neonatal Research Network Terminology		
C	C98971	Laryngomalacia	Laryngomalacia		Increased collapsibility of the larynx.	An abnormality characterized by softening of the laryngeal cartilage typically presenting with stridor.	C97173	Congenital Abnormality of the Respiratory System			C99147	Neonatal Research Network Terminology		
C	C102977	Meconium Peritonitis	Meconium Peritonitis		Inflammation of the peritoneum caused by an intrauterine intestinal perforation leading to presence of meconium within the fetal peritoneal cavity. This is frequently seen as intra-abdominal calcifications on imaging.	Inflammation of the peritoneum caused by an intrauterine intestinal perforation leading to presence of meconium within the fetal peritoneal cavity. This is frequently seen as intra-abdominal calcifications on imaging.	C26726	Infectious Disorder			C99147	Neonatal Research Network Terminology		
C	C35576	Mucocutaneous Candidiasis	Mucocutaneous Candidiasis		A fungal infection of the skin, nails, oral and vaginal mucosal sites caused by species of the genus Candida. It manifests with white discoloration of the tongue and swelling, redness, and tenderness of the nails.		C26726	Infectious Disorder	C3371	Integumentary System Disorder	C99147	Neonatal Research Network Terminology		
C	C99231	Neonatal Infectious Disorder	Neonatal Infectious Disorder		An infectious disorder that occurs during the neonatal period. Representative examples include streptococcal infection, E.coli infection, and bacterial meningitis.	A disorder in a newborn infant up to 28 days old resulting from the presence and activity of a bacterial, fungal, viral, or parasitic agent. It can transmitted antenatally, perinatally or postnatally.	C26726	Infectious Disorder	C98996	Neonatal Disorder	C99147	Neonatal Research Network Terminology		
C	C99236	Neonatal Lupus Erythematosus	Neonatal Lupus Erythematosus		A self-limited skin rash that appears in the neonatal period and usually resolves in four to six months after birth. It is caused by placental transfer of maternal autoantibodies, usually anti-Ro antibody. In a minority of cases, it is associated with congenital heart block, hepatitis, or thrombocytopenia. The mothers of the affected babies may be asymptomatic or suffer from systemic lupus erythematosus, Sjogren's syndrome, or rheumatoid arthritis.	A disorder caused by placental transfer of maternal autoantibodies, usually anti-Ro (SSA) and/or anti-La (SSB), leading to fetal tissue damage associated with congenital heart block, and reversible manifestations such as skin rash, thrombocytopenia, and hepatitis.	C98996	Neonatal Disorder			C99147	Neonatal Research Network Terminology		
C	C27560	Respiratory Distress Syndrome	Neonatal Respiratory Distress Syndrome	Respiratory Distress Syndrome in the Newborn	A condition beginning in the first day of life that results from inadequate surfactant production, causing increased work of breathing and impaired gas exchange.	Progressive alveolar atelectasis from birth due to an abnormality of synthesis, function or metabolism of surfactant, characterized by respiratory failure and an abnormal chest radiograph showing diffuse reticulogranular densities and air bronchograms.	C97173	Congenital Abnormality of the Respiratory System	C99232	Neonatal Respiratory System Disorder	C99147	Neonatal Research Network Terminology		
C	C50685	Pallor	Pallor		An unusual or extreme paleness, state of decreased skin or mucosal coloration.	A condition characterized by an abnormal loss of color to the skin or mucous membranes due to reduced delivery of saturated hemoglobin.	C100104	Signs or Symptoms			C99147	Neonatal Research Network Terminology		
C	C99013	Periventricular Leukomalacia	Periventricular Leukomalacia		Necrosis and softening of the white matter around the ventricles in the brain. It is usually seen in preterm infants and caused by lack of blood flow and oxygenation in the periventricular brain parenchyma.	A form of cerebral white matter injury usually seen in preterm infants that is characterized by necrotic degeneration or gliosis of white matter adjacent to the cerebral ventricles, that may evolve into focal cysts.	C98920	Encephalomalacia			C99147	Neonatal Research Network Terminology		
C	C85006	Persistent Fetal Circulation	Persistent Fetal Circulation	PPHN|Persistent Pulmonary Hypertension of the Newborn	A cardiopulmonary disorder characterized by systemic arterial hypoxemia secondary to pulmonary hypertension and extrapulmonary right to left shunting across the foramen ovale and ductus arteriosus.	A cardiopulmonary disorder characterized by systemic arterial hypoxemia secondary to pulmonary hypertension and extrapulmonary right to left shunting across the foramen ovale and ductus arteriosus.	C35729	Congenital Cardiovascular Abnormality	C98996	Neonatal Disorder	C99147	Neonatal Research Network Terminology		
C	C92866	Recurrent Deceleration	Recurrent Deceleration		Fetal heart rate decelerations that occur with greater than or equal to 50 percent of uterine contractions within a 20 minute timeframe. Applies to early, late or variable decelerations.	Fetal heart rate decelerations that occur with greater than or equal to 50 percent of uterine contractions within a 20 minute timeframe. Applies to early, late or variable decelerations.	C92789	Fetal Heart Rate Deceleration			C99147	Neonatal Research Network Terminology		
C	C3358	Rhabdomyoma	Rhabdomyoma	Rhabdomyomatous Neoplasm	A benign mesenchymal tumor arising from skeletal or cardiac muscle.		C3262	Neoplasm			C99147	Neonatal Research Network Terminology		
C	C98609	TORCH Syndrome	TORCH Syndrome	Toxoplasmosis, Other Infections, Rubella, Cytomegalovirus, and Herpes Simplex Virus (TORCH) Syndrome	A syndrome that results from a group of infections that affect the fetus or the newborn. The group of infections includes Toxoplasma gondii, rubella, cytomegalovirus, herpes simplex virus, and other infections. The other infections include varicella-zoster virus, hepatitis B virus, human immunodeficiency virus, parvovirus B19, and syphilis. Signs and symptoms include fever, feeding difficulties, petechial rash, jaundice, hepatosplenomegaly, chorioretinitis, and microcephaly.	An infection caused by bacteria, viruses or parasites transmitted directly from the mother to an embryo, fetus or neonate during pregnancy or childbirth. Clinical manifestations may include intrauterine growth restriction; a petechial rash, jaundice, hepatosplenomegaly; chorioretinitis, intracranial calcification and other abnormalities of the brain; and congenital heart defects.	C3101	Genetic Disorder	C26726	Infectious Disorder	C99147	Neonatal Research Network Terminology		
C	C98590	Type I Total Anomalous Pulmonary Venous Return	Type I Total Anomalous Pulmonary Venous Return	TAPVR Type I|Total Anomalous Pulmonary Venous Return,  Type I (Supracardiac)|Type I (Supracardiac) Total Anomalous Pulmonary Venous Return	Total anomalous pulmonary venous return in which the pulmonary veins drain into the right atrium via the superior vena cava.	Total Anomalous Pulmonary Venous Return (TAPVR) is a rare congenital malformation in which all four pulmonary veins do not connect normally to the left atrium, but instead drain abnormally to the right atrium by way of an abnormal (anomalous) connection. In type 1, supracardiac TAPVR, the pulmonary veins drain to the right atrium via the superior vena cava.  In this type of TAPVR, the pulmonary veins come together behind the heart and then drain upwards to an abnormal vertical vein.  This vein joins the innominate vein which connects to the right superior vena cava and drains to the right atrium.	C98585	Total Anomalous Pulmonary Venous Return			C99147	Neonatal Research Network Terminology		
C	C98592	Type II Total Anomalous Pulmonary Venous Return	Type II Total Anomalous Pulmonary Venous Return	TAPVR Type II|Total Anomalous Pulmonary Venous Return,  Type II (Intracardiac)|Type II (Intracardiac) Total Anomalous Pulmonary Venous Return	Total anomalous pulmonary venous return in which the pulmonary veins drain into the right atrium via the coronary sinus.	Total Anomalous Pulmonary Venous Return (TAPVR) is a rare congenital malformation in which all four pulmonary veins do not connect normally to the left atrium, but instead drain abnormally to the right atrium by way of an abnormal (anomalous) connection. In type 2, intracardiac TAPVR, the pulmonary veins come together behind the heart and then drains to the right atrium through the coronary sinus.  The coronary sinus is the vein that normally returns blood from the heart muscle itself back to the right atrium after its oxygen has been depleted.  The coronary sinus drains directly into the right atrium.	C98585	Total Anomalous Pulmonary Venous Return			C99147	Neonatal Research Network Terminology		
C	C98597	Type III Total Anomalous Pulmonary Venous Return	Type III Total Anomalous Pulmonary Venous Return	TAPVR Type III|Total Anomalous Pulmonary Venous Return,  Type III (Infradiaphragmatic/Infracardiac)|Type III (Infradiaphragmatic/Infracardiac) Total Anomalous Pulmonary Venous Return	Total anomalous pulmonary venous return in which the common pulmonary vein connects to the portal venous system through the diaphragm.	Total Anomalous Pulmonary Venous Return (TAPVR) is a rare congenital malformation in which all four pulmonary veins do not connect normally to the left atrium, but instead drain abnormally to the right atrium by way of an abnormal (anomalous) connection. In type 3, infracardiac TAPVR, the pulmonary veins drain to the right atrium via the hepatic (liver) veins and inferior vena cava.  In this type, the pulmonary veins join together behind the heart and then typically drain downwards, connecting to the liver's portal vein system.  They then drain through the vascular bed of the liver and enter the right atrium from the hepatic veins.	C98585	Total Anomalous Pulmonary Venous Return			C99147	Neonatal Research Network Terminology		
C	C98598	Type IV Total Anomalous Pulmonary Venous Return	Type IV Total Anomalous Pulmonary Venous Return	TAPVR Type IV|Total Anomalous Pulmonary Venous Return,  Type IV (Mixed)|Type IV (Mixed) Total Anomalous Pulmonary Venous Return	Total anomalous pulmonary venous return in which the right and left pulmonary arteries drain into different sites.	Total Anomalous Pulmonary Venous Return (TAPVR) is a rare congenital malformation in which all four pulmonary veins do not connect normally to the left atrium, but instead drain abnormally to the right atrium by way of an abnormal (anomalous) connection. In type 4, TAPVR, the right and left pulmonary arteries drain into different sites.	C98585	Total Anomalous Pulmonary Venous Return			C99147	Neonatal Research Network Terminology		
C	C50791	Urinary Tract Infection	Urinary Tract Infection	Urinary Tract Infectious Disease	A bacterial infectious process affecting any part of the urinary tract, most commonly the bladder and the urethra. Symptoms include urinary urgency and frequency, burning sensation during urination, lower abdominal discomfort, and cloudy urine.	An infection affecting one or more parts of the urinary tract.	C26726	Infectious Disorder	C3430	Urinary System Disorder	C99147	Neonatal Research Network Terminology		
C	C96407	Varicella Zoster Infection	Varicella Zoster Infection	Varicella-Zoster Virus Infection	A highly contagious viral infection caused by the varicella zoster virus. Clinically, it may be manifested as shingles or chicken pox.		C3439	Viral Infection			C99147	Neonatal Research Network Terminology