C C101028 Neonatal Aspiration of Amniotic Fluid Neonatal Aspiration of Amniotic Fluid Inhalation of fluid from the amniotic sac into the lungs by the neonate. C98996 Neonatal Disorder C83507 Aspiration|Respiratory Tract Aspiration C99147 Neonatal Research Network Terminology C C101035 Neonatal Injury Related to Birth Neonatal Injury Related to Birth An injury sustained to a neonate during the birthing process. C3671 Injury C99147 Neonatal Research Network Terminology C C101036 Retinopathy of Prematurity with Plus Disease Retinopathy of Prematurity with Plus Disease A stage of retinopathy of prematurity characterized by the presence of the following in at least two quadrants around the optic nerve: dilation and tortuosity of major retinal vasculature as a result of increased blood flow. C34982 Retinopathy of Prematurity C99147 Neonatal Research Network Terminology C C101037 Transient Tachypnea of the Newborn Transitory Tachypnea of Newborn A respiratory disorder characterized by higher than normal respiratory rates among premature and cesarean section delivered neonates whose lungs have not fully matured. The cause is often excess fluid in the lungs, and resolution is aided by supplemental oxygen and sometimes, antibiotics. C99232 Neonatal Respiratory System Disorder C99147 Neonatal Research Network Terminology C C101198 Congenital Facial Nerve Palsy Congenital Facial Nerve Palsy Partial or complete paralysis of the facial muscles of one side of an individual's face that is present at birth. It is caused by damage to the seventh cranial nerve. C97172 Congenital Nervous System Disorder C26769 Facial Nerve Palsy C99147 Neonatal Research Network Terminology C C101199 Congenital Phrenic Nerve Palsy Congenital Phrenic Nerve Palsy Phrenic Nerve Palsy, Congenital Damage to the phrenic nerve that results in paralysis of the hemidiaphragm at birth. C97172 Congenital Nervous System Disorder C27580 Peripheral Nervous System Disorder C99147 Neonatal Research Network Terminology C C101200 Neonatal Alloimmune Thrombocytopenia Neonatal Alloimmune Thrombocytopenia Neonatal Thrombocytopenia due to Platelet Alloimmunization Thrombocytopenia that occurs in neonates as a consequence of transplacental passage of maternal alloantibodies directed against fetal platelet antigens. C98995 Neonatal Thrombocytopenia C99147 Neonatal Research Network Terminology C C101201 Myelomeningocele Myelomeningocele A congenital abnormality in which the spinal cord and meninges protrude through a defect in the spinal column. The protrusion is above the skin surface. C101214 Spina Bifida C99147 Neonatal Research Network Terminology C C101270 Kernicterus related to Isoimmunization Kernicterus related to Isoimmunization Kernicterus due to Isoimmunization Encephalopathy in infants due to high levels of unconjugated bilirubin that are a result of Rh incompatibility between the mother and the fetus. C26920 Encephalopathy C99147 Neonatal Research Network Terminology C C101272 Spinal Cord Infarct during Birth Spinal Cord Infarct during Birth Ischemic necrosis of the spinal cord due to spinal artery occlusion during the birthing process. C101035 Birth Injury|Neonatal Injury Related to Birth C99147 Neonatal Research Network Terminology C C101278 Spinal Injury Related to Birth Spinal Injury Related to Birth Spinal Injury Related to Birth Trauma An injury to the spine sustained during the birthing process. C101035 Birth Injury|Neonatal Injury Related to Birth C50750 Spinal Cord Injury C99147 Neonatal Research Network Terminology C C101312 Immature Retinopathy of Prematurity Immature Retinopathy of Prematurity Retinopathy of Prematurity, Immature An immature state in which retinopathy of prematurity cannot be established. Retinopathy of prematurity occurs in premature infants who are born before the retinal vessels complete their normal growth. It results in disorganized growth of retinal blood vessels, which may lead to scarring and retinal detachment. C34982 Retinopathy of Prematurity C99147 Neonatal Research Network Terminology C C101317 Fracture of Long Bone Related to Birth Fracture of Long Bone Related to Birth Fracture of Long Bone Related to Birth Trauma An injury sustained during the birthing process in which the continuity is broken in any bone that is longer in length than width. C116822 Fracture Related to Birth C99147 Neonatal Research Network Terminology C C101318 Fracture of Skull Related to Birth Fracture of Skull Related to Birth Fracture of Skull Related to Birth Trauma An injury sustained during the birthing process in which the continuity is broken in the skull. C116822 Fracture Related to Birth C50745 Skull Fracture C99147 Neonatal Research Network Terminology C C101321 Neonatal Drug Withdrawal Neonatal Drug Withdrawal DWN|Drug Withdrawal Syndrome in Newborn A constellation of neurobehavioral features observed following cessation or reduction of antenatal or postnatal drug exposure. C98996 Neonatal Disorder C103170 Postnatal Drug Withdrawal C99147 Neonatal Research Network Terminology C C101324 Perinatal Intraventricular Hemorrhage Perinatal Intraventricular Hemorrhage Bleeding within the cerebral ventricles occurring around the time of birth. C50896 Intraventricular Hemorrhage C99261 Perinatal Intracranial Hemorrhage C99147 Neonatal Research Network Terminology C C102975 Fracture of Clavicle Related to Birth Fracture of Clavicle Related to Birth Fracture of Clavicle Related to Birth Trauma An injury sustained during the birthing process in which the continuity is broken in the clavicle. C101317 Fracture of Long Bone Related to Birth C99147 Neonatal Research Network Terminology C C102977 Meconium Peritonitis Meconium Peritonitis Inflammation of the peritoneum caused by an intrauterine intestinal perforation leading to presence of meconium within the fetal peritoneal cavity. This is frequently seen as intra-abdominal calcifications on imaging. C26726 Infectious Disease C99147 Neonatal Research Network Terminology C C102990 Brachial Plexus Palsy Related to Birth Brachial Plexus Palsy Related to Birth Brachial Plexus Palsy due to Birth Trauma Birth injury to the brachial plexus. It results in paralysis of the muscles of the shoulder, arm, and hand. It manifests as lack of mobility in the arm, usually in the first week of life. In the majority of cases there is spontaneous recovery. C101035 Birth Injury|Neonatal Injury Related to Birth C3310 Paralysis C99147 Neonatal Research Network Terminology C C103156 Congenital Phrenic Nerve Injury Congenital Phrenic Nerve Injury Phrenic Nerve Injury, Congenital Damage to the phrenic nerve that is present at birth. C27580 Peripheral Nervous System Disorder C99016 Phrenic Nerve Injury C99147 Neonatal Research Network Terminology C C103187 Perinatal Subependymal Hemorrhage with Intraventricular and Intracerebral Extension Perinatal Subependymal Hemorrhage with Intraventricular and Intracerebral Extension A hemorrhage that involves the subependymal region, the lateral cerebral ventricles and the brain tissue occurring around the time of birth. C117201 Perinatal Subependymal Hemorrhage C99147 Neonatal Research Network Terminology C C103188 Acquired Phrenic Nerve Injury Acquired Phrenic Nerve Injury Phrenic Nerve Injury, Acquired Damage to the phrenic nerve that was not present at birth. C27580 Peripheral Nervous System Disorder C99016 Phrenic Nerve Injury C99147 Neonatal Research Network Terminology C C103189 Acquired Phrenic Nerve Palsy Acquired Phrenic Nerve Palsy Damage to the phrenic nerve that results in paralysis of the hemidiaphragm and was not present at birth. C27580 Peripheral Nervous System Disorder C99147 Neonatal Research Network Terminology C C103228 Perinatal Jaundice Related to Inspissated Bile Syndrome Perinatal Jaundice Related to Inspissated Bile Syndrome Perinatal Jaundice due to Inspissated Bile Syndrome Yellow pigmentation of the skin, mucous membranes and eyes due to hyperbilirubinemia caused by inspissated bile plugs in the bile ducts during the perinatal period. C3143 Jaundice C99147 Neonatal Research Network Terminology C C103921 Lissencephaly Lissencephaly A rare genetic brain malformation characterized by smooth folds and grooves in the brain. There are approximately 20 different types of lissencephaly that are identified by various symptoms. C97172 Congenital Nervous System Disorder C99147 Neonatal Research Network Terminology C C106273 ABO Hemolytic Disease of the Newborn ABO Isoimmunization Hemolytic Disease due to ABO Isoimmunization A condition of the newborn characterized by the destruction of red blood cells initiated by the transmission of anti-A or anti-B antibodies from a mother to the child via the placenta against A or B antigens of the newborn's blood. C101304 Hemolytic Disease of the Newborn C99147 Neonatal Research Network Terminology C C110923 Chorioretinitis Chorioretinitis Inflammation of the distal posterior uveal tract (choroid) and its structural and vascular attachments to the retina. It is usually caused by infection and though rare, it is clinically significant due to its most serious sequela: loss of vision. C115993 Retinitis C99147 Neonatal Research Network Terminology C C110927 Physiologic Hyperbilirubinemia Physiological Hyperbilirubinemia Elevated bilirubin levels in the blood of a newborn infant. It is a normal response due to the limited ability to excrete bilirubin until the maturation of the neonatal liver is complete. C99235 Neonatal Hyperbilirubinemia C99147 Neonatal Research Network Terminology C C110940 Panhypopituitarism Panhypopituitarism Insufficient production of all the anterior pituitary hormones. C3009 Endocrine System Disorder C99147 Neonatal Research Network Terminology C C25215 Karyotype Karyotype The assessment of the chromosomal morphology and number in somatic cells of an individual. C15709 Genetic Testing C99147 Neonatal Research Network Terminology C C26691 Adrenocortical Insufficiency Adrenocortical Insufficiency Adrenal Cortical Hypofunction An endocrine or hormonal disorder that occurs when the adrenal cortex does not produce enough of the hormone cortisol and in some cases, the hormone aldosterone. It may be due to a disorder of the adrenal cortex (Addison's disease or primary adrenal insufficiency) or to inadequate secretion of ACTH by the pituitary gland (secondary adrenal insufficiency). C3009 Endocrine System Disorder C99147 Neonatal Research Network Terminology C C26698 Apnea Apnea Transient cessation of respiration. C100104 Sign or Symptom C99147 Neonatal Research Network Terminology C C26713 Cataract Cataract Partial or complete opacity of the crystalline lens of one or both eyes that decreases visual acuity and eventually results in blindness. Some cataracts appear in infancy or in childhood, but most develop in older individuals. (Sternberg Diagnostic Surgical Pathology, 3rd ed.) C26767 C99147 Neonatal Research Network Terminology C C26715 Cellulitis Cellulitis Inflammation of the dermis and subcutaneous tissues caused by a bacterial infection. Symptoms include erythema, edema, and pain to the affected area. C2890 Bacterial Disease C99147 Neonatal Research Network Terminology C C26740 Dehydration Dehydration A condition resulting from the excessive loss of water from the body. It is usually caused by severe diarrhea, vomiting or diaphoresis. C9229 Systemic Disorder C99147 Neonatal Research Network Terminology C C26769 Facial Nerve Palsy Facial Nerve Palsy Facial Palsy Partial or complete paralysis of the facial muscles of one side of a person's face. It is caused by damage to the seventh cranial nerve. It is usually temporary but it may recur. C26733 Cranial Nerve Disorder C99147 Neonatal Research Network Terminology C C26781 Gastroesophageal Reflux Disease Gastroesophageal Reflux Disease A chronic disorder characterized by reflux of the gastric and/or duodenal contents into the distal esophagus. It is usually caused by incompetence of the lower esophageal sphincter. Symptoms include heartburn and acid indigestion. It may cause injury to the esophageal mucosa. C2990 Gastrointestinal Disorder C99147 Neonatal Research Network Terminology C C26782 Glaucoma Glaucoma Increased pressure in the eyeball due to obstruction of the outflow of aqueous humor. C26767 C99147 Neonatal Research Network Terminology C C26791 Hemorrhage Hemorrhage The flow of blood from a ruptured blood vessel. C2931 Cardiovascular Disorder C99147 Neonatal Research Network Terminology C C26800 Hypothyroidism Hypothyroidism Abnormally low levels of thyroid hormone. C3009 Endocrine System Disorder C99147 Neonatal Research Network Terminology C C26828 Meningitis Meningitis A disorder characterized by acute inflammation of the meninges of the brain and/or spinal cord. C27582 Central Nervous System Infectious Disease C99147 Neonatal Research Network Terminology C C26872 Respiratory Failure Respiratory Failure The significant impairment of gas exchange within the lungs resulting in hypoxia, hypercarbia, or both, to the extent that organ tissue perfusion is severely compromised. Causes include chronic obstructive pulmonary disease, asthma, emphysema, acute respiratory distress syndrome, pneumonia, pulmonary edema, pneumothorax, and congestive heart failure. Treatment requires intubation and mechanical ventilation until the time the lungs recover sufficient function. C26871 Respiratory System Disorder C99147 Neonatal Research Network Terminology C C26878 Rickets Rickets Bone softening and weakening usually caused by deficiency or impaired metabolism of vitamin D. Deficiency of calcium, magnesium, or phosphorus may also cause rickets. It predominantly affects children who suffer from severe malnutrition. It manifests with bone pain, fractures, muscle weakness, and skeletal deformities. C26836 Nutritional Disorder C99147 Neonatal Research Network Terminology C C26891 Thrombosis Thrombosis The formation of a blood clot in the lumen of a vessel or heart chamber; causes include coagulation disorders and vascular endothelial injury. C35117 C99147 Neonatal Research Network Terminology C C27088 Hyperbilirubinemia Hyperbilirubinemia Abnormally high level of bilirubin in the blood. Excess bilirubin is associated with jaundice. C100104 Sign or Symptom C99147 Neonatal Research Network Terminology C C27996 Myocardial Infarction Myocardial Infarction Gross necrosis of the myocardium, as a result of interruption of the blood supply to the area, as in coronary thrombosis. C3079 Heart Disorder C25738 Infarct C99147 Neonatal Research Network Terminology C C28129 Renal Tubular Acidosis Renal Tubular Acidosis Failure of the renal tubules of the kidney to excrete urine of normal acidity resulting in metabolic acidosis. It may lead to hypercalcinuria, nephrolithiasis, and renal failure. Causes include autoimmune disorders (e.g., Sjogren syndrome, systemic lupus erythematosus, and rheumatoid arthritis), medications (e.g., non steroidal anti-inflammatory drugs, diuretics, and blood pressure medications), Fanconi syndrome, or it may be familiar. C27120 Electrolyte Disorder C3149 Kidney Disease C99147 Neonatal Research Network Terminology C C2849 Congenital Abnormality Congenital Abnormality Congenital Anomalies of Fetus|Congenital Deformity|Congenital Malformation Any abnormality, anatomical or biochemical, evident at birth or during the neonatal period. C36287 C89328 Pediatric Disorder C99147 Neonatal Research Network Terminology C C2869 Anemia Anemia A reduction in the number of red blood cells, the amount of hemoglobin, and/or the volume of packed red blood cells. Clinically, anemia represents a reduction in the oxygen-transporting capacity of a designated volume of blood, resulting from an imbalance between blood loss (through hemorrhage or hemolysis) and blood production. Signs and symptoms of anemia may include pallor of the skin and mucous membranes, shortness of breath, palpitations of the heart, soft systolic murmurs, lethargy, and fatigability. C26323 Hematologic Disorder C99147 Neonatal Research Network Terminology C C2902 Coagulation Disorder Coagulation Defect A condition in which there is a deviation from or interruption of the normal coagulation properties of the blood. C2931 Cardiovascular Disorder C26323 Hematologic Disorder C99147 Neonatal Research Network Terminology C C2962 Seizure Seizure Sudden, involuntary skeletal muscular contractions of cerebral or brain stem origin. C87124 Central Nervous System Signs and Symptoms C99147 Neonatal Research Network Terminology C C2992 Disseminated Intravascular Coagulation Disseminated Intravascular Coagulation A pathological process where the blood starts to coagulate throughout the whole body. This depletes the body of its platelets and coagulation factors, and there is an increased risk of hemorrhage. C2902 Coagulation Defect|Coagulopathy C99147 Neonatal Research Network Terminology C C3002 Edema Edema Accumulation of an excessive amount of fluid in cells or intercellular tissues. C100104 Sign or Symptom C99147 Neonatal Research Network Terminology C C3020 Seizure Disorder Seizure Disorder A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions. C96413 Brain Disorder C99147 Neonatal Research Network Terminology C C3046 Fracture Fracture Fracture of Bone A traumatic injury to the bone in which the continuity of the bone is broken. C3671 Injury C99147 Neonatal Research Network Terminology C C3085 Hemangioma Hemangioma A benign vascular neoplasm characterized by the formation of capillary-sized or cavernous vascular channels. C3262 Neoplasm C99147 Neonatal Research Network Terminology C C3111 Hydrocephalus Hydrocephalus A disorder characterized by an abnormal increase of cerebrospinal fluid in the ventricles of the brain. C96413 Brain Disorder C99147 Neonatal Research Network Terminology C C3119 Portal Hypertension Portal Hypertension Increased blood pressure in the portal venous system. It is most commonly caused by cirrhosis. Other causes include portal vein thrombosis, Budd-Chiari syndrome, and right heart failure. Complications include ascites, esophageal varices, encephalopathy, and splenomegaly. C3368 Gastrointestinal System Signs and Symptoms C3117 Hypertension C99147 Neonatal Research Network Terminology C C3120 Pulmonary Hypertension Pulmonary Hypertension Increased pressure within the pulmonary circulation due to lung or heart disorder. C3117 Hypertension C99147 Neonatal Research Network Terminology C C3123 Hyperthyroidism Hyperthyroidism Overactivity of the thyroid gland resulting in overproduction of thyroid hormone and increased metabolic rate. Causes include diffuse hyperplasia of the thyroid gland (Graves' disease), single nodule in the thyroid gland, and thyroiditis. The symptoms are related to the increased metabolic rate and include weight loss, fatigue, heat intolerance, excessive sweating, diarrhea, tachycardia, insomnia, muscle weakness, and tremor. C3009 Endocrine System Disorder C99147 Neonatal Research Network Terminology C C3128 Hypotension Hypotension Low Blood Pressure Blood pressure that is abnormally low. C35552 Cardiovascular System Finding C99147 Neonatal Research Network Terminology C C3143 Jaundice Jaundice Yellow pigmentation of the skin, mucous membranes, and the eyes due to hyperbilirubinemia. Causes include liver disease, biliary tract obstruction, and hemolysis. C3368 Gastrointestinal System Signs and Symptoms C36281 Integumentary System Finding C99147 Neonatal Research Network Terminology C C3161 Leukemia Leukemia Leukemia, Disease A malignant (clonal) hematologic disorder, involving hematopoietic stem cells and characterized by the presence of primitive or atypical myeloid or lymphoid cells in the bone marrow and the blood. Leukemias are classified as acute or chronic based on the degree of cellular differentiation and the predominant cell type present. Leukemia is usually associated with anemia, fever, hemorrhagic episodes, and splenomegaly. Common leukemias include acute myeloid leukemia, chronic myelogenous leukemia, acute lymphoblastic or precursor lymphoblastic leukemia, and chronic lymphocytic leukemia. Treatment is vital to patient survival; untreated, the natural course of acute leukemias is normally measured in weeks or months, while that of chronic leukemias is more often measured in months or years. C9305 Cancer|Malignant Neoplasm C99147 Neonatal Research Network Terminology C C3214 Malabsorption Syndrome Malabsorption Syndrome A syndrome resulting from the inadequate absorption of nutrients in the small intestine. Symptoms include abdominal pain, bloating, and diarrhea. C2990 Gastrointestinal Disorder C99147 Neonatal Research Network Terminology C C3222 Medulloblastoma Medulloblastoma A malignant, invasive embryonal neoplasm arising from the cerebellum. It occurs predominantly in children and has the tendency to metastasize via the cerebrospinal fluid pathways. Signs and symptoms include truncal ataxia, disturbed gait, lethargy, headache, and vomiting. There are four histologic variants: anaplastic medulloblastoma, desmoplastic/nodular medulloblastoma, large cell medulloblastoma, and medulloblastoma with extensive nodularity. C9305 Cancer|Malignant Neoplasm C99147 Neonatal Research Network Terminology C C3270 Neuroblastoma Neuroblastoma A neuroblastic tumor characterized by the presence of neuroblastic cells, the absence of ganglion cells, and the absence of a prominent Schwannian stroma formation. C9305 Cancer|Malignant Neoplasm C99147 Neonatal Research Network Terminology C C3319 Pericardial Effusion Pericardial Effusion Fluid collection within the pericardial sac, usually due to inflammation. C101327 Pericardial Anomaly C99147 Neonatal Research Network Terminology C C3331 Pleural Effusion Pleural Effusion Increased amounts of fluid within the pleural cavity. Symptoms include shortness of breath, cough, and chest pain. It is usually caused by lung infections, congestive heart failure, pleural and lung tumors, connective tissue disorders, and trauma. C26871 Respiratory System Disorder C99147 Neonatal Research Network Terminology C C3359 Rhabdomyosarcoma Rhabdomyosarcoma A rare aggressive malignant mesenchymal neoplasm arising from skeletal muscle. It usually occurs in children and young adults. Only a small percentage of tumors arise in the skeletal muscle of the extremities. The majority arise in other anatomical sites. C9118 Sarcoma C99147 Neonatal Research Network Terminology C C3364 Septicemia Sepsis Sepsis Syndrome The presence of pathogenic microorganisms in the blood stream causing a rapidly progressing systemic reaction that may lead to shock. Symptoms include fever, chills, tachycardia, and increased respiratory rate. It is a medical emergency that requires urgent medical attention. C2890 Bacterial Disease C99147 Neonatal Research Network Terminology C C3390 Cerebrovascular Accident Cerebrovascular Accident Stroke A sudden loss of neurological function secondary to hemorrhage or ischemia in the brain parenchyma due to a vascular event. C50438 Intracranial Hemorrhage C99147 Neonatal Research Network Terminology C C3408 Thrombocytopenia Thrombocytopenia Thrombocytopenic Disorder A condition in which there is an abnormally small number of platelets in the circulating blood. C26323 Hematologic Disorder C36292 Laboratory Test Result C99147 Neonatal Research Network Terminology C C34599 Excoriation Excoriation Excoriation of Skin Self-inflicted tearing or wearing off of skin. C36281 Integumentary System Finding C100104 Sign or Symptom C99147 Neonatal Research Network Terminology C C34690 Inguinal Hernia Inguinal Hernia The protrusion of a sac-like structure containing fibroadipose tissue through an abnormal opening in the inguinal region. C34685 Hernia C99147 Neonatal Research Network Terminology C C34749 Acute Tubular Necrosis Acute Tubular Necrosis Acute renal failure caused by the cell death of the renal tubules. Causes include nephrotoxins, cytotoxic drugs, and antibiotics. C3149 Kidney Disease C99147 Neonatal Research Network Terminology C C34781 Spastic Diplegia Spastic Diplegia A type of cerebral palsy characterized by spasticity and hypertonia of the lower extremities bilaterally, particularly the legs, hips, and pelvis; this is the most common (70%) form of cerebral palsy. C34460 Cerebral Palsy C99147 Neonatal Research Network Terminology C C34786 Long QT Syndrome Long QT Syndrome A ventricular arrhythmia characterized by a long QT interval, and accompanied by syncopal episodes sometimes leading to sudden death due to paroxysmal ventricular arrhythmia. This arrhythmia is associated with a prolongation of repolarization following depolarization of the cardiac ventricles. The prolongation of the Q-T interval combined with torsades de pointes manifests as several different forms; some may be acquired or congenital; some may lead to serious arrhythmia and sudden cardiac death. C95834 Congenital Heart Disease C99147 Neonatal Research Network Terminology C C34830 Cardiomyopathy Cardiomyopathy A disease of the heart muscle or myocardium proper. Cardiomyopathies may be classified as either primary or secondary, on the basis of etiology, or on the pathophysiology of the lesion: hypertrophic, dilated, or restrictive. C3079 Heart Disorder C101216 Myopathy C99147 Neonatal Research Network Terminology C C34966 Pyloric Stenosis Pyloric Stenosis Narrowing of the pyloric lumen caused either by hypertrophy of the surrounding muscles or tissue scarring due to a chronic peptic ulcer. C2990 Gastrointestinal Disorder C99147 Neonatal Research Network Terminology C C34982 Retinopathy of Prematurity Retinopathy of Prematurity A bilateral retinopathy characterized by neovascularization, scarring, retinal detachment, and eventually blindness. It may be mild or severe. It occurs in babies born prematurely. Causes include oxygen toxicity and hypoxia. C98996 Neonatal Disorder C62601 Retinopathy C99147 Neonatal Research Network Terminology C C35016 Shock Shock A life-threatening condition that requires immediate medical intervention. It is characterized by reduced blood flow that may result in damage of multiple organs. Types of shock include cardiogenic, hemorrhagic, septic, anaphylactic, and traumatic shock. C2931 Cardiovascular Disorder C99147 Neonatal Research Network Terminology C C35061 Supraventricular Tachycardia Supraventricular Tachycardia A disorder characterized by an electrocardiographic finding of a tachycardia which does not originate in the ventricles or His Purkinje system. There is an abnormally high heart rate and QRS complexes are typically narrow, but aberration or preexcitation may be present. (CDISC) C110938 Tachyarrhythmia C99147 Neonatal Research Network Terminology C C35145 Appendicitis Appendicitis Acute inflammation of the vermiform appendix. Appendicitis is a condition characterized by inflammation of the appendix, a small pouch attached to the beginning of the large intestine. C2990 Gastrointestinal Disorder C26726 Infectious Disease C99147 Neonatal Research Network Terminology C C35524 Leukocytosis Leukocytosis A laboratory test result indicating an increased number of white blood cells in the peripheral blood. C36292 Laboratory Test Result C99147 Neonatal Research Network Terminology C C35530 Thrombocytosis Thrombocytosis A hematology test result that indicates the presence of higher than normal platelet counts in the peripheral blood. C26323 Hematologic Disorder C36292 Laboratory Test Result C99147 Neonatal Research Network Terminology C C35549 Hypoxic Ischemic Encephalopathy Hypoxic Ischemic Encephalopathy HIE Ischemic brain damage in which the entire brain is deprived of oxygen. It may be fatal or lead to long term disabilities including developmental delays, intellectual disability, and seizures. C26920 Encephalopathy C99147 Neonatal Research Network Terminology C C3728 Hepatoblastoma Hepatoblastoma A malignant liver neoplasm that occurs almost exclusively in infants, although isolated cases in older children and adults have been reported. Grossly, hepatoblastoma is solid, well circumscribed, and more often solitary than multiple. Microscopically, most of the tumors are composed exclusively of immature hepatocytic elements. About a fourth of hepatoblastomas contain a stromal component that may be undifferentiated or develop into bone or cartilage. The treatment of choice for hepatoblastoma is surgical excision with adjuvant therapy. Liver transplantation is being increasingly used as well. C9305 Cancer|Malignant Neoplasm C99147 Neonatal Research Network Terminology C C37968 Hyperkalemia Hyperkalemia Higher than normal levels of potassium in the circulating blood; associated with kidney failure or sometimes with the use of diuretic drugs. C27120 Electrolyte Disorder C99147 Neonatal Research Network Terminology C C37969 Hypermagnesemia Hypermagnesemia Higher than normal levels of magnesium in the circulating blood. C27120 Electrolyte Disorder C99147 Neonatal Research Network Terminology C C37973 Hypocalcemia Hypocalcemia Lower than normal levels of calcium in the circulating blood. Hypocalcaemia is an electrolyte disturbance in which the serum calcium levels in the blood are low (less than 2.1 mmol/L). C27120 Electrolyte Disorder C99147 Neonatal Research Network Terminology C C37975 Hypomagnesemia Hypomagnesemia Lower than normal levels of magnesium in the circulating blood. Hypomagnesemia is an electrolyte disturbance in which there is an abnormally low level of magnesium in the blood (less than 0.7 mmol/L) C27120 Electrolyte Disorder C99147 Neonatal Research Network Terminology C C37976 Hyponatremia Hyponatremia Lower than normal levels of sodium in the circulating blood. Hyponatremia is an electrolyte disturbance in which the sodium concentration in the serum is lower than normal. Sodium homeostasis is vital to the normal physiologic function of cells. Hyponatremia is defined as a serum level of less than 135 mEq/L and is considered severe when the serum level is below 125 mEq/L. C27120 Electrolyte Disorder C99147 Neonatal Research Network Terminology C C38006 Pneumothorax Pneumothorax Abnormal presence of air in the pleural cavity. C26871 Respiratory System Disorder C99147 Neonatal Research Network Terminology C C38038 Tremor Tremor The shaking movement of the whole body or just a certain part of it, often caused by problems of the neurons responsible for muscle action. C100104 Sign or Symptom C99147 Neonatal Research Network Terminology C C3890 Hypoxia Hypoxia A decrease in the amount of oxygen in the body. Symptoms range from mild (impaired judgment, memory loss, impaired motor coordination) to severe (seizures and coma). C45233 Respiratory System Finding C99147 Neonatal Research Network Terminology C C3988 Syndrome of Inappropriate Antidiuretic Hormone Secretion Syndrome of Inappropriate Antidiuretic Hormone Secretion Inappropriate ADH Secretion|Syndrome of Inappropriate Vasopressin Secretion A syndrome characterized by abnormal secretion of antidiuretic hormone in conjunction with neoplastic growth occurring anywhere in the body. C3009 Endocrine System Disorder C99147 Neonatal Research Network Terminology C C43263 Diabetes Insipidus Diabetes Insipidus A disorder characterized by excretion of large amounts of urine, accompanied by excessive thirst. Causes include deficiency of antidiuretic hormone or failure of the kidneys to respond to antidiuretic hormone. It may also be drug-related. C3009 Endocrine System Disorder C99147 Neonatal Research Network Terminology C C4371 Gestational Hypertension Gestational Hypertension Pregnancy-Induced Hypertension A blood pressure elevation after 20 weeks of gestation in the absence of either proteinuria or systemic findings like thrombocytopenia, impaired liver function, progressive renal insufficiency, pulmonary edema or the new-onset of cerebral or visual disturbances. C3117 Hypertension C34941 Pregnancy Complication C99147 Neonatal Research Network Terminology C C47814 Vocal Cord Paralysis Vocal Cord Paralysis Vocal Cord Palsy Paralysis of the muscles of one or both vocal cords. Signs and symptoms include hoarseness, weak voice, dyspnea, and coughing. Affected individuals are at risk for aspiration pneumonia. C26835 Nervous System Disorder C118420 C99147 Neonatal Research Network Terminology C C48259 Hyperparathyroidism Hyperparathyroidism Hyperfunction of the parathyroid glands resulting in the overproduction of parathyroid hormone. It may be primary or secondary; primary hyperparathyroidism is caused by parathyroid adenoma, parathyroid hyperplasia, parathyroid carcinoma, and multiple endocrine neoplasia. It is associated with hypercalcemia and hypophosphatemia. Signs and symptoms include weakness, fatigue, nausea, vomiting, constipation, depression, bone pain, osteoporosis, cystic bone lesions, and kidney stones. Secondary hyperparathyroidism is caused by the chronic stimulation of the parathyroid glands in patients with chronic renal failure, rickets, and malabsorption syndromes. C3009 Endocrine System Disorder C99147 Neonatal Research Network Terminology C C48592 Gastrointestinal Hemorrhage Gastrointestinal Hemorrhage Bleeding originating from any part of the gastrointestinal tract. C2990 Gastrointestinal Disorder C26791 Hemorrhage C99147 Neonatal Research Network Terminology C C50466 Atrial Fibrillation Atrial Fibrillation A disorder characterized by an electrocardiographic finding of a supraventricular arrhythmia characterized by the replacement of consistent P waves by rapid oscillations or fibrillatory waves that vary in size, shape and timing and are accompanied by an irregular ventricular response. (CDISC) C27158 Supraventricular Arrhythmia C99147 Neonatal Research Network Terminology C C50484 Cephalohematoma Cephalohematoma Cephalhematoma A subperiosteal hemorrhage limited to the surface of one cranial bone, a usually benign condition seen in the newborn as a result of bone trauma. C81236 Birth Complication C92719 Fetal Disorder C99147 Neonatal Research Network Terminology C C50501 Complete Atrioventricular Block Complete Atrioventricular Block Non-Congenital Complete Atrioventricular Block A disorder characterized by an electrocardiographic finding of complete failure of atrial electrical impulse conduction to the ventricles. This is manifested on the ECG by disassociation of atrial and ventricular rhythms. The atrial rate must be faster than the ventricular rate. (CDISC) C2881 Arrhythmia C99147 Neonatal Research Network Terminology C C50685 Pallor Pallor An unusual or extreme paleness, state of decreased skin or mucosal coloration. C100104 Sign or Symptom C99147 Neonatal Research Network Terminology C C50713 Pulmonary Embolism Pulmonary Embolism The obstruction of the pulmonary artery or one of its branches by an embolus, sometimes associated with infarction of the lung. C26759 C99147 Neonatal Research Network Terminology C C50791 Urinary Tract Infection Urinary Tract Infection Urinary Tract Infectious Disease A bacterial infectious process affecting any part of the urinary tract, most commonly the bladder and the urethra. Symptoms include urinary urgency and frequency, burning sensation during urination, lower abdominal discomfort, and cloudy urine. C26726 Infectious Disease C3430 Urinary System Disorder C99147 Neonatal Research Network Terminology C C50799 Ventricular Fibrillation Ventricular Fibrillation A disorder characterized by an electrocardiographic finding of a rapid grossly irregular ventricular rhythm with marked variability in QRS cycle length, morphology, and amplitude. The rate is typically greater than 300 bpm. (CDISC) C26924 Ventricular Arrhythmia C99147 Neonatal Research Network Terminology C C50802 Ventricular Tachycardia Ventricular Tachycardia A disorder characterized by an electrocardiographic finding of three or more consecutive complexes of ventricular origin with a rate greater than a certain threshold (100 or 120 beats per minute are commonly used). The QRS complexes are wide and have an abnormal morphology. (CDISC) C26924 Ventricular Arrhythmia C99147 Neonatal Research Network Terminology C C51224 Atrial Flutter Atrial Flutter A disorder characterized by an electrocardiographic finding of an organized, regular atrial rhythm with atrial rate of 240-340 beats per minute. Multiple P waves typically appear in the inferior leads in a saw tooth-like pattern between the QRS complexes. (CDISC) C27158 Supraventricular Arrhythmia C99147 Neonatal Research Network Terminology C C7541 Retinoblastoma Retinoblastoma A malignant tumor that originates in the nuclear layer of the retina. As the most common primary tumor of the eye in children, retinoblastoma is still relatively uncommon, accounting for only 1% of all malignant tumors in pediatric patients. These tumors may be multifocal, bilateral, congenital, inherited, or acquired. Seventy-five percent of retinoblastomas are unilateral; 60% occur sporadically. A predisposition to retinoblastoma has been associated with 13q14 cytogenetic abnormalities. Patients with the inherited form also appear to be at increased risk for secondary nonocular malignancies such as osteosarcoma, malignant fibrous histiocytoma, and fibrosarcoma. C9305 Cancer|Malignant Neoplasm C99147 Neonatal Research Network Terminology C C78350 Hypoparathyroidism Hypoparathyroidism An endocrine disorder characterized by decreased production of parathyroid hormone by the parathyroid glands. It is usually caused by damage of the parathyroid glands during head and neck surgery. Signs and symptoms include muscle cramps, abdominal pain, dry skin, brittle nails, cataracts, tetany, and convulsions. C3009 Endocrine System Disorder C99147 Neonatal Research Network Terminology C C78592 Recurrent Laryngeal Nerve Paralysis Recurrent Laryngeal Nerve Paralysis Vagus Nerve Laryngeal Paralysis Paralysis of the recurrent laryngeal nerve. Causes include surgical and non-surgical traumas, neoplasms (e.g., lung carcinoma), and inflammatory neuritis. C26733 Cranial Nerve Disorder C103171 Recurrent Laryngeal Nerve Injury C99147 Neonatal Research Network Terminology C C78718 Wheezing Wheezing A symptom and a finding during physical examination, characterized by a high-pitched, whistling sound during breathing. It results from the narrowing or obstruction of the respiratory airways. The most common causes of wheezing are asthma, chronic obstructive pulmonary disease, tracheobronchitis, and pulmonary edema. C100104 Sign or Symptom C99147 Neonatal Research Network Terminology C C79546 Chylothorax Chylothorax A milky pleural effusion resulting from accumulation of lymph fluid in the pleural cavity. Causes include malignancies (usually lymphoma), trauma to the thoracic duct, tuberculosis, sarcoidosis, and congenital causes. C3331 Pleural Effusion|Pleural effusion C99147 Neonatal Research Network Terminology C C81255 Head Circumference Head Circumference A circumferential measurement of the head at the widest point, which is traditionally above the eyebrows. C25334 Length C99147 Neonatal Research Network Terminology C C81282 Dubowitz Score Dubowitz Score The numerical value that represents a clinical assessment of neurological and physical criteria, performed between birth and five days of age, to determine an infant's gestational age and maturity. C118807 C99147 Neonatal Research Network Terminology C C81283 Red Reflex Test Red Reflex Test Red Reflex Vision Test An optic examination in which an ophthalmoscope or retinoscope is placed approximately 30cm from the eye to visualize whether a reddish hue is reflected from the retina. C84749 Newborn Examination C99147 Neonatal Research Network Terminology C C81306 Breathing Effort Score Breathing Effort Score A component of the Apgar score, it is the numerical value assigned to the assessment of breathing effort by a neonate. 0 = no spontaneous respirations; 1 = slow or irregular respirations or a weak cry; 2 = strong, consistent respirations with a robust cry. C118807 C99147 Neonatal Research Network Terminology C C81309 Heart Rate Score Heart Rate Score A component of the Apgar score, it is the numerical value assigned to an assessment of the circulatory status of a neonate. 0 = no pulse; 1 = rate less than 100 beats per minute; 2 = rate greater than 100 beats per minute. C35552 Cardiovascular System Finding C99147 Neonatal Research Network Terminology C C81311 Moro Reflex Moro Reflex An involuntary, primal response in the neonate to loud noise or the feeling of falling. The response is characterized by the infant's arms symmetrically spreading out to the side and then back to the midline, and involuntarily flexing the fingers and toes. C81181 Infant Reflex C99147 Neonatal Research Network Terminology C C81312 Muscle Tone Score Muscle Tone Score A component of the Apgar score, it is the numerical value assigned to an assessment of the residual muscle tension of a neonate. 0 = flaccid; 1 = flexion of extremities; 2 = active motion. C118807 C99147 Neonatal Research Network Terminology C C81314 Newborn Behavioral Examination Newborn Behavioral Examination The assessment of behavior in neonates. C84749 Newborn Examination C99147 Neonatal Research Network Terminology C C81319 Reflex Irritability Score Reflex Irritability Score A component of the Apgar score, it is the numerical value assigned to the neonate's response to stimuli, such as a mild pinch. 0 = no reaction; 1 = grimace; 2 = grimace with a cough, sneeze, or vigorous cry. C118807 C99147 Neonatal Research Network Terminology C C81321 Skin Color Score Skin Color Score A component of the Apgar score, it is the numerical value assigned to an assessment of the color of the skin of a neonate. 0 = pale blue; 1 = pink body and pale blue extremities; 2 = pink body and extremities. C36281 Integumentary System Finding C99147 Neonatal Research Network Terminology C C81323 Sucking Reflex Sucking Reflex An involuntary, primal response in the neonate when a nipple is placed on an infant's lips. C81181 Infant Reflex C99147 Neonatal Research Network Terminology C C81324 Tonic Neck Reflex Tonic Neck Reflex An involuntary, primal response in the neonate in which the arm extends to follow the infant's gaze, while the opposing arm and leg flex inward. C81181 Infant Reflex C99147 Neonatal Research Network Terminology C C83006 Cholestasis Cholestasis Impairment of the bile flow caused by obstruction within the liver, or outside the liver in the bile duct system. C2990 Gastrointestinal Disorder C99147 Neonatal Research Network Terminology C C83507 Respiratory Tract Aspiration Respiratory Tract Aspiration Accidental inhalation of a foreign material into the lungs. C45233 Respiratory System Finding C99147 Neonatal Research Network Terminology C C84446 Neonatal Hepatitis Neonatal Hepatitis Hepatitis developing during the neonatal period. C2990 Gastrointestinal Disorder C98996 Neonatal Disorder C99147 Neonatal Research Network Terminology C C84479 Thrombophilia Thrombophilia Hypercoagulability State A condition characterized by an abnormally high level of thrombi. Causes include thrombotic thrombocytopenic purpura, disseminated intravascular coagulation, bone marrow disorders, and antiphospholipid antibody syndrome. C2902 Coagulation Defect|Coagulopathy C99147 Neonatal Research Network Terminology C C84506 Ventricular Septal Defect Ventricular Septal Defect The presence of a defect (opening) in the septum that separates the two ventricles of the heart. It can be congenital or acquired. C84482 Congenital Septal Defect C99147 Neonatal Research Network Terminology C C84552 Amniotic Band Syndrome Amniotic Band Syndrome Deformity due to Amniotic Band A rare congenital disorder which is caused by entrapment of anatomic parts of the fetus in fibrous amniotic bands during pregnancy. It may result in the formation of constriction rings around the digits and upper and lower extremities, swelling of the extremities and congenital amputations. C2849 Congenital Abnormality|Congenital Malformation C99147 Neonatal Research Network Terminology C C84641 Clubfoot Clubfoot Talipes Equinovarus The most common congenital deformation of the foot, occurring in 1 of 1,000 live births. The most common form is talipes equinovarus, where the deformed foot is turned downward and inward sharply. C84978 Osteochondrodysplasia|Skeletal Dysplasia C99147 Neonatal Research Network Terminology C C84713 Fetal Alcohol Syndrome Fetal Alcohol Syndrome A teratogenic disorder observed in a newborn or child of a mother who consumed alcohol during pregnancy. Manifestations of the syndrome include low birth weight, atypical facies, microcephaly, failure to thrive, developmental defects, organ dysfunction, mental deficiencies, poor motor coordination and behavioral problems. C92780 Fetal Alcohol Spectrum Disorder C99147 Neonatal Research Network Terminology C C84750 HELLP Syndrome HELLP Syndrome Hemolysis-Elevated Liver Enzymes-Low Platelet Count Syndrome Severe preeclampsia associated with any of the following findings: thrombocytopenia (platelets less than 100,000 per microliter), impaired liver function (twice normal elevation of hepatic transaminases; severe, persistent right upper quadrant or epigastric pain), progressive renal insufficiency (serum creatinine greater than 1.1 mg/dL or doubling of baseline in the absence of other renal disease), pulmonary edema, or new-onset cerebral or visual disturbances. C85021 Preeclampsia C99147 Neonatal Research Network Terminology C C84767 Hydrops Fetalis Hydrops Fetalis A condition characterized by fluid accumulation in two or more anatomic compartments in the fetus. C92719 Fetal Disorder C99147 Neonatal Research Network Terminology C C84799 Kernicterus Kernicterus Bilirubin Encephalopathy A rare neurologic disorder occurring in infants with jaundice. It results from brain damage by existing high levels of unconjugated-indirect bilirubin. C26920 Encephalopathy C99147 Neonatal Research Network Terminology C C84915 Necrotizing Enterocolitis Necrotizing Enterocolitis A fulminating disease of neonates in which there is extensive mucosal ulceration, pseudomembrane formation, submucosal hemorrhage, and necrosis usually of the right colon, cecum, terminal ileum, and appendix, possibly due to perinatal intestinal ischemia and bacterial invasion. Progression can lead to necrosis, perforation and/or scarring of the intestinal tract. C98996 Neonatal Disorder C99147 Neonatal Research Network Terminology C C84978 Osteochondrodysplasia Osteochondrodysplasia Congenital Skeletal Dysplasia A term referring to disorders characterized by abnormalities in the development of bones and cartilage. C89337 Congenital Musculoskeletal Defect C99147 Neonatal Research Network Terminology C C85006 Persistent Fetal Circulation Persistent Fetal Circulation Persistent Pulmonary Hypertension of the Newborn A cardiopulmonary disorder characterized by systemic arterial hypoxemia secondary to pulmonary hypertension and extrapulmonary right to left shunting across the foramen ovale and ductus arteriosus. C35729 Congenital Abnormality of the Circulatory System|Congenital Cardiovascular Abnormality C98996 Neonatal Disorder C99147 Neonatal Research Network Terminology C C85038 Infant Failure to Thrive Infant Failure to Thrive Failure to Thrive in Infant|Failure to Thrive A clinical finding indicating less than normal growth in infancy. C89330 Developmental Disorder C99147 Neonatal Research Network Terminology C C87070 Hypotonia Hypotonia Poor Muscle Tone A condition of decreased tone of the skeletal muscles and diminished resistance to passive stretching. C100104 Sign or Symptom C99147 Neonatal Research Network Terminology C C87077 Congenital Ankyloblepharon Congenital Ankyloblepharon A congenital abnormality in which the margins of the upper and lower eyelids are fused together by bands of tissue. C99208 Eye Finding C99147 Neonatal Research Network Terminology C C87085 Hypertonia Hypertonia Increased Muscle Tone A condition of increased muscle tone manifested by increased resistance of the muscle to passive stretching. C100104 Sign or Symptom C99147 Neonatal Research Network Terminology C C87093 Meconium Aspiration Syndrome Meconium Aspiration Syndrome A serious condition in which a newborn breathes a mixture of meconium (the first intestinal discharge) and amniotic fluid into the lungs around the time of delivery. Meconium aspiration syndrome occurs in 5-10 percent of births and typically occurs when the infant is stressed, as when the infant is past its due date. C97173 Congenital Respiratory System Disorder C99147 Neonatal Research Network Terminology C C87118 Sacral Dimple Sacral Dimple A small hollow area or sinus present at birth and located just above the crease of the buttocks. In most cases, pilonidal dimples are benign and may just be accompanied by increased hair growth in the area. C100104 Sign or Symptom C99147 Neonatal Research Network Terminology C C87169 High Pitched Cry High Pitched Cry An abnormally shrill or screeching vocalization made by infants that could possibly indicate the presence of one of an array of medical conditions or congenital syndromes. C100104 Sign or Symptom C99147 Neonatal Research Network Terminology C C89515 Neonatal Abstinence Syndrome Assessment Neonatal Abstinence Syndrome Assessment The measurement of the degree to which a neonate is experiencing symptoms of withdrawal due to maternal substance abuse; the score can be used to determine subsequent treatment of the infant. C84749 Newborn Examination C99147 Neonatal Research Network Terminology C C89516 Neuromuscular Maturity Assessment Neuromuscular Maturity Assessment A neuromuscular examination of a newborn's developmental characteristics. C84749 Newborn Examination C99147 Neonatal Research Network Terminology C C89519 Popliteal Angle Measurement Popliteal Angle Measurement An examination whereby the patient is placed supine, the hip is flexed 90 degrees, and the knee is extended until firm resistance is met. The popliteal angle is the angle from the tibia to the femur. This measurement is used to assess hamstring contracture in children with cerebral palsy. C84749 Newborn Examination C99147 Neonatal Research Network Terminology C C90599 Bronchopulmonary Dysplasia Bronchopulmonary Dysplasia Chronic lung disease requiring treatment with oxygen for at least 28 days and with a spectrum of severity from mild to severe, that predominantly affects premature infants. While the radiologic pattern is typical in the closer to term patient, the pattern in the small preterm infant is very non-discrete and variable. C97173 Congenital Respiratory System Disorder C99147 Neonatal Research Network Terminology C C9175 Bowel Obstruction Bowel Obstruction Intestinal Obstruction Blockage of the normal flow of the intestinal contents within the bowel. C2990 Gastrointestinal Disorder C99147 Neonatal Research Network Terminology C C9224 Esophagitis Esophagitis An acute or chronic inflammatory process affecting the esophageal wall. C2990 Gastrointestinal Disorder C99147 Neonatal Research Network Terminology C C92716 Fetal Heart Rate Fetal Heart Rate The number of fetal cardiac beats per minute. C49677 Heart Rate C99147 Neonatal Research Network Terminology C C92741 Baseline Fetal Heart Rate Baseline Fetal Heart Rate The number of fetal cardiac beats per minute, considered as the reference value against which measurements in the future can be made. C92716 Fetal Heart Rate C99147 Neonatal Research Network Terminology C C92770 Early Deceleration Early Deceleration Early Fetal Heart Deceleration A gradual decrease in the fetal heart rate and return to baseline that is associated with a uterine contraction. The nadir of the deceleration occurs at the same time as the peak of the uterine contraction, and the time from onset to nadir of the deceleration is greater than or equal to 30 seconds. C92789 Fetal Heart Deceleration|Fetal Heart Rate Deceleration C99147 Neonatal Research Network Terminology C C92782 Fetal Bradycardia Fetal Bradycardia A fetal heart rate below 110 bpm that is sustained for longer than 10 minutes. C92715 Fetal Heart Finding C99147 Neonatal Research Network Terminology C C92786 Fetal Fibronectin Test Fetal Fibronectin Test Fetal Fibronectin Measurement A test for the presence of fetal fibronectin in the cervico-vaginal area that is used to predict preterm birth. C25294 Laboratory Procedure C99147 Neonatal Research Network Terminology C C92788 Fetal Heart Acceleration Fetal Heart Acceleration Fetal Heart Rate Acceleration An abrupt increase is defined as an increase from the onset of acceleration to the peak in less than 30 seconds. To be called an acceleration, the peak must be greater than or equal to 15 bpm, and the acceleration must last greater than or equal to 15 seconds from the onset to return to baseline. C92715 Fetal Heart Finding C99147 Neonatal Research Network Terminology C C92789 Fetal Heart Deceleration Fetal Heart Deceleration A decrease in the fetal heart rate that has a duration of less than 10 minutes. C92715 Fetal Heart Finding C99147 Neonatal Research Network Terminology C C92790 Fetal Heart Rate Variability Fetal Heart Rate Variability Fluctuations in the baseline fetal heart rate, determined in a 10 minute window while excluding accelerations and decelerations. They are irregular in amplitude and frequency and are visually quantitated as the amplitude of the peak to trough in beats per minute. Sinusoidal patterns are also excluded. C92715 Fetal Heart Finding C99147 Neonatal Research Network Terminology C C92791 Fetal Heart Tone Fetal Heart Tone The sounds of the fetal heart. C92715 Fetal Heart Finding C99147 Neonatal Research Network Terminology C C92792 Fetal Heart Tone Location Fetal Heart Tone Location The site of fetal cardiac sounds that can be distinctly detected in relation to the maternal abdomen. C92715 Fetal Heart Finding C99147 Neonatal Research Network Terminology C C92796 Fetal Tachycardia Fetal Tachycardia A fetal heart rate above 160 bpm that is sustained for longer than 10 minutes. C92715 Fetal Heart Finding C92719 Fetal Disorder C99147 Neonatal Research Network Terminology C C92816 Intermittent Deceleration Intermittent Deceleration Fetal heart rate decelerations that occur with less than 50 percent of uterine contractions within a 20 minute timeframe. C92789 Fetal Heart Deceleration|Fetal Heart Rate Deceleration C99147 Neonatal Research Network Terminology C C92822 Late Deceleration Late Deceleration Late Fetal Heart Deceleration A gradual decrease in the fetal heart rate and return to baseline that is associated with a uterine contraction. The nadir of the deceleration occurs after the peak of the uterine contraction, and the time from onset to nadir of the deceleration is greater than or equal to 30 seconds. C92789 Fetal Heart Deceleration|Fetal Heart Rate Deceleration C99147 Neonatal Research Network Terminology C C92863 Prolonged Acceleration Prolonged Acceleration Prolonged Fetal Heart Rate Acceleration A fetal heart rate acceleration that lasts 2 to less than 10 minutes. C92788 Fetal Heart Acceleration|Fetal Heart Rate Acceleration C99147 Neonatal Research Network Terminology C C92864 Prolonged Deceleration Prolonged Deceleration Finding of Prolonged Deceleration A decrease in the fetal heart rate below baseline lasting 2 to less than 10 minutes with a decrease from baseline that is greater than or equal to 15 beats per minute. C92789 Fetal Heart Deceleration|Fetal Heart Rate Deceleration C99147 Neonatal Research Network Terminology C C92866 Recurrent Deceleration Recurrent Deceleration Fetal heart rate decelerations that occur with greater than or equal to 50 percent of uterine contractions within a 20 minute timeframe. Applies to early, late or variable decelerations. C92789 Fetal Heart Deceleration|Fetal Heart Rate Deceleration C99147 Neonatal Research Network Terminology C C92914 Variable Deceleration Variable Deceleration Finding of Variable Deceleration An abrupt decrease in the fetal heart rate below baseline that lasts 15 seconds to less than two minutes. The decrease from baseline fetal heart rate is greater than or equal to 15 beats per minutes, and the time from onset to nadir of the deceleration is less than 30 seconds. Variable fetal heart rate decelerations that are associated with successive uterine contractions commonly have varying onsets, depths, and durations. C92789 Fetal Heart Deceleration|Fetal Heart Rate Deceleration C99147 Neonatal Research Network Terminology C C92929 Fetal Heart Monitoring Fetal Heart Monitoring Fetal Heart Rate Monitoring The act of observing and recording the fetal heart rate for determining the baseline values or other abnormal findings. C90341 Pediatric Intervention or Procedure C99147 Neonatal Research Network Terminology C C9305 Malignant Neoplasm Malignant Neoplasm Malignant Neoplastic Disease A tumor composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas (adenocarcinomas or squamous cell carcinomas), Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas. C3262 Neoplasm C99147 Neonatal Research Network Terminology C C98609 TORCH Syndrome TORCH Syndrome Toxoplasmosis, Other Infections, Rubella, Cytomegalovirus, and Herpes Simplex Virus (TORCH) Syndrome A syndrome that results from a group of infections that affect the fetus or the newborn. The group of infections includes Toxoplasma gondii, rubella, cytomegalovirus, herpes simplex virus, and other infections. The other infections include varicella-zoster virus, hepatitis B virus, human immunodeficiency virus, parvovirus B19, and syphilis. Signs and symptoms include fever, feeding difficulties, petechial rash, jaundice, hepatosplenomegaly, chorioretinitis, and microcephaly. C3101 Genetic Disorder C26726 Infectious Disease C99147 Neonatal Research Network Terminology C C98619 Parenteral Nutrition - Associated Cholestasis Parenteral Nutrition - Associated Cholestasis TPN Acquired Cholestasis Cholestasis that results from prolonged total parenteral nutrition. It is caused by diminished bile flow from the liver into the duodenum. It may result in cirrhosis and liver failure. Preterm infants are most susceptible to liver damage. C83006 Cholestasis C99147 Neonatal Research Network Terminology C C98803 Acquired Hydrocephalus Acquired Hydrocephalus Hydrocephalus that results from head trauma, brain tumors, intracranial hemorrhage, or meningitis. C3111 Hydrocephalus C99147 Neonatal Research Network Terminology C C98810 Ambiguous Genitalia Ambiguous Genitalia A rare congenital abnormality in which the infant's external genitalia do not have the typical appearance of a male's or female's genitalia. C103185 Congenital Reproductive System Abnormality C99147 Neonatal Research Network Terminology C C98811 Anasarca Anasarca A condition that is characterized by the presence of generalized edema. Causes include congestive heart failure, liver failure, renal failure, and severe malnutrition. C3002 Edema C99147 Neonatal Research Network Terminology C C98823 Apnea of Prematurity Apnea of Prematurity The cessation of breathing in premature infants that lasts for more than 15-20 seconds. C26698 Apnea C97173 Congenital Respiratory System Disorder C99147 Neonatal Research Network Terminology C C98840 Benign Congenital Hypotonia Benign Congenital Hypotonia Mild hypotonia that usually appears early in infancy and has a favorable outcome. It is not a manifestation of another disorder that may cause hypotonia (e.g., cerebral palsy or muscular dystrophy). C87070 Hypotonia C99147 Neonatal Research Network Terminology C C98846 Breast Milk Jaundice Breast Milk Jaundice Neonatal Jaundice due to Delayed Conjugation from Breast Milk Inhibitors Jaundice in an otherwise healthy breast-fed newborn. It appears four to seven days after birth, lasts longer than the physiologic jaundice, and there are no identifiable causes. C99246 Neonatal Jaundice C99147 Neonatal Research Network Terminology C C98847 Bronchomalacia Bronchomalacia A congenital or acquired abnormality of the wall of the bronchi. In congenital cases, there is lack of rigidity in the cartilage of the bronchial wall. In acquired cases, the cartilage of the bronchial wall is degenerated, secondary to tracheostomy or presence of a breathing tube. Symptoms include noisy breathing and wheezing. C98541 Chronic Lung Disease C99147 Neonatal Research Network Terminology C C98876 Congenital Hydrocephalus Congenital Hydrocephalus Hydrocephalus that is present at birth. C97172 Congenital Nervous System Disorder C3111 Hydrocephalus C99147 Neonatal Research Network Terminology C C98903 Conjoined Twins Conjoined Twins A monoamniotic twin gestation in which the twins share one or more organs. C90491 C99147 Neonatal Research Network Terminology C C98906 Fetal Warfarin Syndrome Fetal Warfarin Syndrome Fetal Coumadin Syndrome A teratogenic disorder observed in a newborn or child of a mother who was exposed to warfarin during pregnancy. Manifestations include nasal bridge depression, nasal bones hypoplasia, microcephaly, congenital heart disorders, and brachydactyly. C92719 Fetal Disorder C99147 Neonatal Research Network Terminology C C98926 Fetal Heart Rhythm Fetal Heart Rhythm The recurrent, measured movements (rhythm) of a beating heart in a fetus. C92715 Fetal Heart Finding C99147 Neonatal Research Network Terminology C C98927 Fetal Hydantoin Syndrome Fetal Hydantoin Syndrome A teratogenic disorder observed in a newborn or child of a mother who was exposed to phenytoin during pregnancy. Manifestations include dysmorphic craniofacial features, hypoplastic distal phalanges and nails, growth delay and delayed psychomotor development. C92719 Fetal Disorder C99147 Neonatal Research Network Terminology C C98928 Fetal Methotrexate Syndrome Fetal Methotrexate Syndrome A teratogenic disorder observed in a newborn or child of a mother who was exposed to methotrexate during pregnancy. Manifestations of the syndrome include craniofacial, digital, and skeletal malformations. C92719 Fetal Disorder C99147 Neonatal Research Network Terminology C C98929 Fetal Retinoid Syndrome Fetal Retinoid Syndrome Fetal Isotretinoin Syndrome|Retinoic Acid Embryopathy A teratogenic disorder observed in a newborn or child of a mother who was exposed to retinoids during pregnancy. Manifestations include growth delay, skull, facial, heart, and central nervous system malformations. C92719 Fetal Disorder C99147 Neonatal Research Network Terminology C C98930 Fetal Valproate Syndrome Fetal Valproate Syndrome A teratogenic disorder observed in a newborn or child of a mother who was exposed to valproic acid during pregnancy. Manifestations include musculoskeletal abnormalities, intellectual disability, spina bifida, and distinctive facial features. C92719 Fetal Disorder C99147 Neonatal Research Network Terminology C C98936 Hematochezia Hematochezia The passage of fresh blood from the anus. The blood is usually seen in the stools. The most common cause is lower gastrointestinal tract hemorrhage. C3368 Gastrointestinal System Signs and Symptoms C99147 Neonatal Research Network Terminology C C98952 Hypertrophic Pyloric Stenosis Hypertrophic Pyloric Stenosis An abnormality characterized by thickening of the muscle in the wall of the pylorus. It results in the narrowing of the pyloric channel. The overlying mucosa may appear hypertrophic as well. Clinical signs and symptoms appear early in life and include projectile vomiting and dehydration. C34966 Pyloric Stenosis C99147 Neonatal Research Network Terminology C C98971 Laryngomalacia Laryngomalacia Increased collapsibility of the larynx. C97173 Congenital Respiratory System Disorder C99147 Neonatal Research Network Terminology C C98980 Meconium Plug Syndrome Meconium Plug Syndrome Meconium Plug A transient colonic dysfunction in the newborn characterized by the delayed passage of meconium and associated intestinal dilatation. C2990 Gastrointestinal Disorder C99147 Neonatal Research Network Terminology C C98990 Neuronal Migration Disorder Neuronal Migration Disorder Migration Defects A diverse group of congenital brain developmental disorders characterized by defects in neuronal migration in the brain during early fetal development. The neuronal migration defects result in brain abnormalities that are usually manifested with mental retardation and epilepsy. C96412 Brain Development Abnormality C97172 Congenital Nervous System Disorder C99147 Neonatal Research Network Terminology C C98995 Neonatal Thrombocytopenia Neonatal Thrombocytopenia A condition characterized by a decrease in the number of platelets in the blood below established reference ranges in a newborn. C98996 Neonatal Disorder C3408 Thrombocytopenia C99147 Neonatal Research Network Terminology C C98996 Neonatal Disorder Neonatal Disorder A non-neoplastic or neoplastic disorder which occurs during the neonatal period. C89328 Pediatric Disorder C99147 Neonatal Research Network Terminology C C99000 Orbital Cellulitis Orbital Cellulitis Inflammation of the eye tissues posterior to the orbital septum, and generally secondary to an infection spread from adjacent sinuses. Signs and symptoms of the affected eye include sudden loss of vision, erythema, edema, decreased eye movement, and pain. Treatment is conducted via intravenous antibiotics, observation, and surgical intervention when necessary. C26715 Cellulitis C99147 Neonatal Research Network Terminology C C99012 Pneumoperitoneum Pneumoperitoneum Free air within the peritoneal cavity. C3368 Gastrointestinal System Signs and Symptoms C99147 Neonatal Research Network Terminology C C99013 Periventricular Leukomalacia Periventricular Leukomalacia Necrosis and softening of the white matter around the ventricles in the brain. It is usually seen in preterm infants and caused by lack of blood flow and oxygenation in the periventricular brain parenchyma. C98920 Encephalomalacia C99147 Neonatal Research Network Terminology C C99017 Phrenic Nerve Palsy Phrenic Nerve Palsy Intermittent, incomplete or complete paralysis with or without tremors to any of the organs or body parts innervated by the phrenic nerve. C27580 Peripheral Nervous System Disorder C99147 Neonatal Research Network Terminology C C99020 Porencephalic Cyst Porencephalic Cyst A congenital or acquired cystic cavity within the cerebral hemisphere. C2978 Cyst C99147 Neonatal Research Network Terminology C C99024 Premature Closure of the Ductus Arteriosus Premature Closure of the Ductus Arteriosus Closure of the ductus arteriosus prior to birth. C35729 Congenital Abnormality of the Circulatory System|Congenital Cardiovascular Abnormality C99137 Great Vessels Abnormality C99147 Neonatal Research Network Terminology C C99042 Renal Vein Thrombosis Renal Vein Thrombosis The formation of a blood clot (thrombus) in the renal vein. C99107 Venous Thrombosis C99147 Neonatal Research Network Terminology C C99044 Retinopathy of Prematurity in Zone 1 Retinopathy of Prematurity in Zone 1 Retinopathy of prematurity located in zone 1 of the retina. C34982 Retinopathy of Prematurity C99147 Neonatal Research Network Terminology C C99045 Retinopathy of Prematurity in Zone 2 Retinopathy of Prematurity in Zone 2 Retinopathy of prematurity located in zone 2 of the retina. C34982 Retinopathy of Prematurity C99147 Neonatal Research Network Terminology C C99046 Retinopathy of Prematurity in Zone 3 Retinopathy of Prematurity in Zone 3 Retinopathy of prematurity located in zone 3 of the retina. C34982 Retinopathy of Prematurity C99147 Neonatal Research Network Terminology C C99047 Retinopathy of Prematurity Stage 1 Demarcation Line Retinopathy of Prematurity Stage 1 - Demarcation Line An ophthalmoscopic finding that refers to retinopathy of prematurity characterized by the presence of a faint demarcation line. Prior to the development of ROP in the premature infant, vascularization of the retina is incomplete or "immature". In Stage 1: Demarcation Line is a thin but definite structure that separates the avascular retina anteriorly from the vascularized retina posteriorly. There is abnormal branching or arcading of vessels leading up to the demarcation line that is relatively flat, white, and lies within the plane of the retina. C34982 Retinopathy of Prematurity C99147 Neonatal Research Network Terminology C C99048 Retinopathy of Prematurity Stage 2 Intraretinal Ridge Retinopathy of Prematurity Stage 2 - Intraretinal Ridge An ophthalmoscopic finding that refers to retinopathy of prematurity characterized by the presence of an elevated ridge. Prior to the development of ROP in the premature infant, vascularization of the retina is incomplete or "immature". In Stage 2: Intraretinal Ridge, the ridge arises from the demarcation line and has height and width, which extends above the plane of the retina. The ridge may change from white to pink and vessels may leave the plane of the retina posterior to the ridge to enter it. C34982 Retinopathy of Prematurity C99147 Neonatal Research Network Terminology C C99049 Retinopathy of Prematurity Stage 3 Ridge with Extraretinal Fibroblastic Proliferation Retinopathy of Prematurity Stage 3 - Ridge with Extraretinal Fibrovascular Proliferation An ophthalmoscopic finding that refers to retinopathy of prematurity characterized by the presence of extraretinal fibrovascular tissue. Prior to the development of ROP in the premature infant, vascularization of the retina is incomplete or "immature". In Stage 3: Ridge with extraretinal fibrovascular proliferation, the neovascularization extends from the ridge into the vitreous. This extraretinal proliferating tissue is continuous with the posterior aspect of the ridge, causing a ragged appearance as the proliferation becomes more extensive. C34982 Retinopathy of Prematurity C99147 Neonatal Research Network Terminology C C99050 Retinopathy of Prematurity Stage 4 Subtotal Retinal Detachment Retinopathy of Prematurity Stage 4 - Subtotal Retinal Detachment An ophthalmoscopic finding that refers to retinopathy of prematurity characterized by the presence of subtotal retinal detachment. Prior to the development of ROP in the premature infant, vascularization of the retina is incomplete or "immature". In Stage 4: Subtotal Retinal Detachment the retinal detachments are generally concave and most are circumferentially oriented. Retinal detachments usually begin at the point of fibrovascular attachment to the vascularized retina and the extent of detachment depends on the amount of neovascularization present. C34982 Retinopathy of Prematurity C99147 Neonatal Research Network Terminology C C99051 Retinopathy of Prematurity Stage 5 Total Retinal Detachment Retinopathy of Prematurity Stage 5 - Total Retinal Detachment An ophthalmoscopic finding that refers to retinopathy of prematurity characterized by the presence of total retinal detachment. Prior to the development of ROP in the premature infant, vascularization of the retina is incomplete or "immature". In Stage 5: Total Retinal Detachment, the retinal detachments are generally tractional and usually funnel shaped. The configuration of the funnel itself is used for subdivision of this stage depending if the anterior and posterior portions are open or narrowed. C34982 Retinopathy of Prematurity C99147 Neonatal Research Network Terminology C C99057 Severe Bronchopulmonary Dysplasia Severe Bronchopulmonary Dysplasia Bronchopulmonary dysplasia that results in severe respiratory complications. The infants with severe symptoms are usually premature, have low birth weight, and the oxygen and ventilation support requirements are increased. C90599 Bronchopulmonary Dysplasia C99147 Neonatal Research Network Terminology C C99082 Thalidomide Embryopathy Syndrome Thalidomide Embryopathy Syndrome Fetal embryopathy associated with maternal thalidomide use during pregnancy characterized by phocomelia of one or all limbs, other limb defects such as thumb abnormalities, and other structural anomalies that may include facial hemangioma, esophageal and duodenal atresia, tetralogy of Fallot, renal agenesis, and anomalies of the external ear. Long term complications may include Moebius syndrome or autism. C92719 Fetal Disorder C99147 Neonatal Research Network Terminology C C99107 Venous Thrombosis Venous Thrombosis The formation of a blood clot (thrombus) in the lumen of a vein. C26891 Thrombosis C99147 Neonatal Research Network Terminology C C99110 Drug Induced Thrombocytopenia Drug Induced Thrombocytopenia Drug-Induced Immune Thrombocytopenia Thrombocytopenia caused by ingested or injected drugs. It may be the result of decreased platelet production due to bone marrow suppression or increased rate of platelet destruction. C3408 Thrombocytopenia C99147 Neonatal Research Network Terminology C C99111 Heparin Induced Thrombocytopenia Heparin-Induced Thrombocytopenia A life-threatening complication of heparin therapy. It results in immune-mediated thrombocytopenia and, in 25-50 percent of the patients, thrombotic complications. C99110 Drug Induced Thrombocytopenia|Drug-Induced Thrombocytopenia C99147 Neonatal Research Network Terminology C C99115 Immature Retinal Vasculature Immature Retinal Vasculature A finding that indicates the presence of immature retinal vessels as a result of prematurity. C26875 Retinal Disorder C99147 Neonatal Research Network Terminology C C99117 Immature Retinal Vasculature in Zone 1 Immature Retinal Vasculature in Zone 1 A finding that indicates the presence of immature retinal vessels in zone 1 of the retina. Prior to the development of ROP in the premature infant, vascularization of the retina is incomplete or "immature". Zone I is a circle, the radius of which extends from the center of the optic disc to twice the distance from the center of the optic disc to the center of the macula. C99115 Immature Retinal Vasculature C99147 Neonatal Research Network Terminology C C99118 Immature Retinal Vasculature in Zone 2 Immature Retinal Vasculature in Zone 2 A finding that indicates the presence of immature retinal vessels in zone 2 of the retina. Prior to the development of ROP in the premature infant, vascularization of the retina is incomplete or "immature". Zone II extends centrifugally from the edge of zone I to the nasal ora serrata. C99115 Immature Retinal Vasculature C99147 Neonatal Research Network Terminology C C99119 Immature Retinal Vasculature in Zone 3 Immature Retinal Vasculature in Zone 3 A finding that indicates the presence of immature retinal vessels in zone 3 of the retina. Prior to the development of ROP in the premature infant, vascularization of the retina is incomplete or "immature". Zone III is the residual crescent of retina anterior to zone II. C99115 Immature Retinal Vasculature C99147 Neonatal Research Network Terminology C C99138 Germinal Matrix Hemorrhage of the Newborn Germinal Matrix Hemorrhage of Newborn Grade 1 Intraventricular (Nontraumatic) Hemorrhage of Fetus and Newborn|Intraventricular (Nontraumatic) Hemorrhage, Grade 1, of Fetus and Newborn Bleeding into the thick layer of immature cells under the ependymal lining at the ventrolateral aspect of the lateral cerebral ventricles of a newborn. C50896 Intraventricular Hemorrhage C98996 Neonatal Disorder C99147 Neonatal Research Network Terminology C C99139 Intraventricular Hemorrhage of the Newborn without Ventricular Dilatation Intraventricular Hemorrhage of the Newborn without Ventricular Dilatation Grade 2 Intraventricular (Nontraumatic) Hemorrhage of Fetus and Newborn|Intraventricular (Nontraumatic) Hemorrhage, Grade 2, of Fetus and Newborn Bleeding into the lateral cerebral ventricles of a newborn infant without acute ventricular dilatation. C50896 Intraventricular Hemorrhage C98996 Neonatal Disorder C99147 Neonatal Research Network Terminology C C99140 Intraventricular Hemorrhage of the Newborn with Ventricular Dilatation Intraventricular Hemorrhage of the Newborn with Ventricular Dilatation Grade 3 Intraventricular (Nontraumatic) Hemorrhage of Fetus and Newborn|Intraventricular (Nontraumatic) Hemorrhage, Grade 3, of Fetus and Newborn Bleeding into the lateral cerebral ventricles of a newborn infant with ventricular dilatation directly attributable to the acute bleeding. C50896 Intraventricular Hemorrhage C98996 Neonatal Disorder C99147 Neonatal Research Network Terminology C C99231 Neonatal Infectious Disorder Neonatal Infectious Disorder An infectious disorder that occurs during the neonatal period. Representative examples include streptococcal infection, E.coli infection, and bacterial meningitis. C26726 Infectious Disease C98996 Neonatal Disorder C99147 Neonatal Research Network Terminology C C99233 Neonatal Rickets Neonatal Rickets Osteopenia of Prematurity Rickets that usually affects premature infants. Factors that contribute to the development of neonatal rickets include calcium, phosphorus, or calciferol deficiency. It manifests with spontaneous fractures, respiratory distress, and growth developmental delays. C98996 Neonatal Disorder C26878 Rickets C99147 Neonatal Research Network Terminology C C99235 Neonatal Hyperbilirubinemia Neonatal Hyperbilirubinemia Increased levels of bilirubin in the blood during the neonatal period. In the majority of cases it is seen in the first week of life and usually there is no underlying disease, however, it may also occur in hemolytic diseases, infections, metabolic disorders, and liver abnormalities. C27088 Hyperbilirubinemia C99147 Neonatal Research Network Terminology C C99236 Neonatal Lupus Erythematosus Neonatal Lupus Erythematosus A self-limited skin rash that appears in the neonatal period and usually resolves in four to six months after birth. It is caused by placental transfer of maternal autoantibodies, usually anti-Ro antibody. In a minority of cases, it is associated with congenital heart block, hepatitis, or thrombocytopenia. The mothers of the affected babies may be asymptomatic or suffer from systemic lupus erythematosus, Sjogren's syndrome, or rheumatoid arthritis. C98996 Neonatal Disorder C99147 Neonatal Research Network Terminology C C99246 Neonatal Jaundice Neonatal Jaundice Jaundice that appears during the neonatal period. In the majority of cases, it appears in the first week of life and is classified as physiologic due to accelerated destruction of erythrocytes and liver immaturity. In a minority of cases it is classified as non-physiologic, appearing in the first twenty four hours after birth, and is associated with underlying diseases including hemolytic disorders, polycythemia, and cephalohematoma. C3143 Jaundice C99147 Neonatal Research Network Terminology C C99248 Neonatal Diabetes Mellitus Neonatal Diabetes Mellitus Hyperglycemia in the newborn due to a defect in the secretion or function of insulin. C2985 C98996 Neonatal Disorder C99147 Neonatal Research Network Terminology C C99255 Neonatal Opiate Withdrawal Syndrome Neonatal Opiate Withdrawal Syndrome A constellation of neurobehavioral features observed in a neonate following cessation or reduction of postnatal exposure to opioids. C101321 Neonatal Drug Withdrawal C99147 Neonatal Research Network Terminology C C99261 Perinatal Intracranial Hemorrhage Perinatal Intracranial Hemorrhage Bleeding within the skull of a newborn infant occurring around the time of birth. C50438 Intracranial Hemorrhage C35095 Perinatal Disorder C99147 Neonatal Research Network Terminology C C3336 Polycythemia Vera Polycythemia Vera A chronic myeloproliferative neoplasm characterized by an increased red blood cell production. The bone marrow is hypercellular due to a panmyelotic proliferation typically characterized by pleomorphic megakarycytes. The major symptoms are related to hypertension, splenomegaly or to episodes of thrombosis and/or hemorrhage. C9305 Cancer|Malignant Neoplasm C99147 Neonatal Research Network Terminology C C34610 Polyostotic Fibrous Dysplasia Polyostotic Fibrous Dysplasia Polyostotic Fibrous Dysplasia of Bone Fibrous dysplasia affecting more than one bone. When it is associated with café-au-lait skin pigmentation and endocrine disorders, it is known as McCune-Albright syndrome. C3101 Genetic Disorder C107377 Musculoskeletal System Disorder C99147 Neonatal Research Network Terminology D C110943 Musculoskeletal Injury Injury of Musculoskeletal System Damage to the muscles, bones and their supportive structral attachments. C3671 Injury C99147 Neonatal Research Network Terminology D C117115 Fatty Acid Metabolism Disorder Fatty Acid Metabolism Disorder Disorder of Fatty Acid Metabolism A group of genetic disorders that result from the inability to produce or use an enzyme required to oxidize fatty acids, resulting in an inability to generate energy from fatty acid sources. C97092 Lipid Metabolism Disorder C99147 Neonatal Research Network Terminology D C77140 Clinical Test Result Clinical Test Result Evaluation Finding The result of a laboratory, radiologic, or other clinical test performed to determine the presence, absence, or degree of a condition. C70856 Observational Result C99147 Neonatal Research Network Terminology D C84509 Primary Malignant Neoplasm Primary Malignant Neoplasm A malignant tumor at the original site of growth. C9305 Cancer|Malignant Neoplasm C99147 Neonatal Research Network Terminology D C85866 Autosomal Recessive Disorder Autosomal Recessive Disorder Autosomal Recessive Hereditary Disorder An inherited disorder manifested only when two copies of a mutated gene are present. C3101 Genetic Disorder C99147 Neonatal Research Network Terminology D C98643 Venous Stenosis Venous Stenosis A finding indicating narrowing of a vein in one or multiple areas. C35117 Vascular Disorder C99147 Neonatal Research Network Terminology D C98829 Autosomal Dominant Disorder Autosomal Dominant Disorder Autosomal Dominant Hereditary Disorder An inherited disorder that manifests when one copy of a mutated gene is present. C3101 Genetic Disorder C99147 Neonatal Research Network Terminology D C99062 Skin Injury Skin Injury Injury of Integument Damage to the skin. C3671 Injury C99147 Neonatal Research Network Terminology