A C100104 Sign or Symptom Signs or Symptoms Objective evidence of disease perceptible to the examining practitioner (sign) and subjective evidence of disease perceived by the patient (symptom). C3367 Finding C89506 NICHD Newborn Screening Terminology A C100104 Sign or Symptom Signs or Symptoms Objective evidence of disease perceptible to the examining practitioner (sign) and subjective evidence of disease perceived by the patient (symptom). C3367 Finding C90259 NICHD Pediatric Terminology D C4876 Symptom Symptom Subjective evidence of disease perceived by the patient. C3367 Finding C89506 NICHD Newborn Screening Terminology D C4876 Symptom Symptom Subjective evidence of disease perceived by the patient. C3367 Finding C90259 NICHD Pediatric Terminology C C3367 Finding Finding Clinical, laboratory or molecular evidence, or absence of evidence of disease. C90259 NICHD Pediatric Terminology C89506 NICHD Newborn Screening Terminology C C3367 Finding Finding Clinical, laboratory or molecular evidence, or absence of evidence of disease. C90259 NICHD Pediatric Terminology C90259 NICHD Pediatric Terminology C C26737 Cyanosis Cyanosis A bluish or purplish discoloration of the skin and mucous membranes resulting from a reduced amount of oxygenated hemoglobin in the blood. C100104 Signs or Symptoms C89506 NICHD Newborn Screening Terminology C C2962 Seizure Seizure Sudden, involuntary skeletal muscular contractions of cerebral or brain stem origin. C100104 Signs or Symptoms C89506 NICHD Newborn Screening Terminology C C3368 Gastrointestinal System Signs and Symptoms Gastrointestinal System Signs and Symptoms Signs and symptoms associated with disturbances within the gastrointestinal system, which includes the stomach, intestines and all associated organs that aid in digestion. C100104 Signs or Symptoms C89506 NICHD Newborn Screening Terminology C C34484 Clonus Clonus A form of involuntary muscular movement characterized by alternating contractions and relaxation in rapid succession. In the context of reflex testing, the ability to elicit clonus indicates injury to the nerve tracts above the point at which the reflex was initiated. C100104 Signs or Symptoms C89506 NICHD Newborn Screening Terminology C C34599 Excoriation Excoriation A superficial traumatic injury to the skin caused most often by scratching, but also by abrasions or by a chemical or thermal burn. C100104 Signs or Symptoms C89506 NICHD Newborn Screening Terminology C C34832 Myoclonic Jerk Myoclonic Jerk A sudden, involuntary contraction of a muscle or group of muscles; these movements may develop as a symptom of a number of neurological diseases including epilepsy, Parkinson's disease, Alzheimer's disease, or Creutzfeldt-Jacob disease. C100104 Signs or Symptoms C89506 NICHD Newborn Screening Terminology C C36172 Sweating Sweating The loss of a watery fluid, consisting mainly of sodium chloride and urea in solution, that is secreted by the sweat glands in the skin of mammals. C100104 Signs or Symptoms C89506 NICHD Newborn Screening Terminology C C38038 Tremor Tremor The shaking movement of the whole body or just a certain part of it, often caused by problems of the neurons responsible for muscle action. C100104 Signs or Symptoms C89506 NICHD Newborn Screening Terminology C C5039 Motor Manifestations Motor Manifestations The presence of an alteration in the ability to move one's body or any body parts in accordance with one's intent. C100104 Signs or Symptoms C89506 NICHD Newborn Screening Terminology C C50589 Hyperthermia Hyperthermia A condition that manifests with abnormally high body temperature. In hyperthermic state, the hypothalamic set-point is normal but body temperature increases and overrides the ability to lose heat, resulting from exogenous heat exposure or endogenous heat production, e.g. in heat stroke, malignant hyperthermia, endocrine hyperthermia, or neuroleptic malignant syndrome. The concept does not refer to hyperpyrexia, the state when the hypothalamic set-point is reset at a higher temperature and is physiologically regulated. C100104 Signs or Symptoms C89506 NICHD Newborn Screening Terminology C C50644 Lung Overinflation Lung Overinflation Abnormal permanent enlargement of the lung air spaces distal to terminal bronchiole not resulted from wall destruction, e.g. due to loss of opposite lung. C100104 Signs or Symptoms C89506 NICHD Newborn Screening Terminology C C50685 Pallor Pallor An unusual or extreme paleness, state of decreased skin coloration. C100104 Signs or Symptoms C89506 NICHD Newborn Screening Terminology C C50726 Regurgitation Regurgitation Flow in the opposite direction from normal, as the casting up of undigested food or gas from the stomach, or the backward flowing of blood into the heart, or between the chambers of the heart when a valve is incompetent. C100104 Signs or Symptoms C89506 NICHD Newborn Screening Terminology C C50746 Sneezing Sneezing A symptom consisting of the involuntary expulsion of air from the nose. C100104 Signs or Symptoms C89506 NICHD Newborn Screening Terminology C C61454 Basilar Rales Basilar Rales Abnormal breath sounds (crackles) heard on auscultation only in the bases of the lungs. They indicate inflammation, fluid, or infection in the air sacs of the lung. C100104 Signs or Symptoms C89506 NICHD Newborn Screening Terminology C C78500 Nasal Congestion Nasal Congestion The blockage of the nasal passage due to mucosal edema. It is usually the result of a viral infection or an allergic reaction. C100104 Signs or Symptoms C89506 NICHD Newborn Screening Terminology C C78718 Wheezing Wheezing A symptom and a finding during physical examination, characterized by a high-pitched, whistling sound during breathing. It results from the narrowing or obstruction of the respiratory airways. The most common causes of wheezing are asthma, chronic obstructive pulmonary disease, tracheobronchitis, and pulmonary edema. C100104 Signs or Symptoms C89506 NICHD Newborn Screening Terminology C C87065 Cyanotic Body Cyanotic Body Blue- or purplish-colored body; this is caused by excessive amounts of deoxygenated hemoglobin in the skin vessels of the body. C100104 Signs or Symptoms C89506 NICHD Newborn Screening Terminology C C87066 Cyanotic Limbs Cyanotic Limbs Blue- or purplish-colored limbs; this is caused by excessive amounts of deoxygenated hemoglobin in the skin vessels of the limbs. C100104 Signs or Symptoms C89506 NICHD Newborn Screening Terminology C C87070 Hypotonia Hypotonia A condition of decreased tone of the skeletal muscles and diminished resistance to passive stretching. C100104 Signs or Symptoms C89506 NICHD Newborn Screening Terminology C C87073 Excessive Sucking Excessive Sucking A symptom of gastrointestinal dysfunction seen in neonates who have been exposed to drugs during pregnancy; often accompanied by excessive sucking of fists, fingers and thumbs. C100104 Signs or Symptoms C89506 NICHD Newborn Screening Terminology C C87085 Hypertonia Hypertonia A condition of increased muscle tone manifested by increased resistance of the muscle to passive stretching. C100104 Signs or Symptoms C89506 NICHD Newborn Screening Terminology C C87087 Intercostal Retractions Intercostal Retractions The marked inward movement of the muscles between the ribs during inhalation; they indicate that there is reduced pressure in the chest cavity and can be a sign of breathing difficulties. C100104 Signs or Symptoms C89506 NICHD Newborn Screening Terminology C C87089 Irregular Respiration Irregular Breathing A change from the normal breathing pattern in an infant, child, or adult, in terms of the amplitude and frequency of inhalations and exhalations. C100104 Signs or Symptoms C89506 NICHD Newborn Screening Terminology C C87095 Mottling Mottling A patchy appearance of the skin caused by underlying blood vessel changes. C100104 Signs or Symptoms C89506 NICHD Newborn Screening Terminology C C87096 Movement of Lip Corners Movement of Lip Corners During examination of the newborn infant, the examiner looks for symmetric movement of the lip corners. Movement of the lip corners is governed by the zygomatic major muscle. C100104 Signs or Symptoms C89506 NICHD Newborn Screening Terminology C C87099 Nasal Flaring Nasal Flaring Enlargement of the nostrils during breathing; although there are many possible causes, it can be a sign of respiratory distress in young infants. C100104 Signs or Symptoms C89506 NICHD Newborn Screening Terminology C C87111 Poor Feeding Poor Feeding Occurs either when an infant shows no interest in feeding or when there is an inability to take in adequate nutrition. Poor feeding is a nonspecific symptom of many disorders, including neurological, genetic, structural, metabolic, and infectious diseases. C100104 Signs or Symptoms C89506 NICHD Newborn Screening Terminology C C87116 Rhonchi Rhonchi An abnormal sound similar to snoring heard on auscultation of the bronchial airways, suggesting a partial obstruction due to thick secretions, a muscular spasm, or a neoplasm. C100104 Signs or Symptoms C89506 NICHD Newborn Screening Terminology C C87124 Central Nervous System Signs and Symptoms Central Nervous System Signs and Symptoms Signs and symptoms associated with disturbances within the central nervous system, which includes the brain, spinal cord and meninges. C100104 Signs or Symptoms C89506 NICHD Newborn Screening Terminology C C87128 Watery Stool Watery Stool Frequent, loose, and watery stools are noted in most infants, even if they are fed formula, until they are six to eight weeks old; after that, the stools become firmer and less frequent. C100104 Signs or Symptoms C89506 NICHD Newborn Screening Terminology C C87129 Weak Breathing Weak Breathing Shallow inhalations and exhalations that indicate respiratory distress. C100104 Signs or Symptoms C89506 NICHD Newborn Screening Terminology C C87131 Yawning Yawning An involuntary deep inhalation with the mouth open, often a sign of drowsiness or boredom. C100104 Signs or Symptoms C89506 NICHD Newborn Screening Terminology C C87169 High Pitched Cry High Pitched Cry A symptom in infants that could possibly indicate the presence of one of an array of medical conditions or congenital syndromes, including birth trauma, craniosynostosis, Arnold-Chiari deformity, meningitis, and cri-du-chat syndrome (deletion of the short arm of chromosome 5). C100104 Signs or Symptoms C89506 NICHD Newborn Screening Terminology C C26737 Cyanosis Cyanosis A bluish or purplish discoloration of the skin and mucous membranes resulting from a reduced amount of oxygenated hemoglobin in the blood. C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C2962 Seizure Seizure Sudden, involuntary skeletal muscular contractions of cerebral or brain stem origin. C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C2987 Diarrhea Diarrhea A condition of frequent and watery bowel movements. C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C3038 Fever Fever The elevation of the body's temperature above the upper limit of normal, usually taken as 37.7 degrees C. C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C3114 Hypersensitivity Allergic Reaction A local or general reaction of an organism following contact with a specific allergen to which it has been previously exposed and to which it has become sensitized. C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C3303 Pain Pain The sensation of discomfort, distress, or agony, resulting from the stimulation of specialized nerve endings. C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C3368 Gastrointestinal System Signs and Symptoms Gastrointestinal System Signs and Symptoms Signs and symptoms associated with disturbances within the gastrointestinal system, which includes the stomach, intestines and all associated organs that aid in digestion. C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C3442 Vomiting Vomiting The reflex act of ejecting the contents of the stomach through the mouth. C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C34484 Clonus Clonus A form of involuntary muscular movement characterized by alternating contractions and relaxation in rapid succession. In the context of reflex testing, the ability to elicit clonus indicates injury to the nerve tracts above the point at which the reflex was initiated. C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C34599 Excoriation Excoriation A superficial traumatic injury to the skin caused most often by scratching, but also by abrasions or by a chemical or thermal burn. C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C34832 Myoclonic Jerk Myoclonic Jerk A sudden, involuntary contraction of a muscle or group of muscles; these movements may develop as a symptom of a number of neurological diseases including epilepsy, Parkinson's disease, Alzheimer's disease, or Creutzfeldt-Jacob disease. C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C36172 Sweating Sweating The loss of a watery fluid, consisting mainly of sodium chloride and urea in solution, that is secreted by the sweat glands in the skin of mammals. C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C37928 Confusion Confusion A mental state characterized by a lack of clear and orderly thought and behavior. C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C38038 Tremor Tremor The shaking movement of the whole body or just a certain part of it, often caused by problems of the neurons responsible for muscle action. C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C39594 Skin Rash Skin Rash Any change in the skin which affects its appearance or texture. A rash may be localized to one part of the body, or affect all the skin. Rashes may cause the skin to change color, itch, become warm, bumpy, dry, cracked or blistered, swell and may be painful. C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C4077 Redness Redness Coloration of the skin; sign of inflammation C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C5039 Motor Manifestations Motor Manifestations The presence of an alteration in the ability to move one's body or any body parts in accordance with one's intent. C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C50589 Hyperthermia Hyperthermia A condition that manifests with abnormally high body temperature. In hyperthermic state, the hypothalamic set-point is normal but body temperature increases and overrides the ability to lose heat, resulting from exogenous heat exposure or endogenous heat production, e.g. in heat stroke, malignant hyperthermia, endocrine hyperthermia, or neuroleptic malignant syndrome. The concept does not refer to hyperpyrexia, the state when the hypothalamic set-point is reset at a higher temperature and is physiologically regulated. C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C50644 Lung Overinflation Lung Overinflation Abnormal permanent enlargement of the lung air spaces distal to terminal bronchiole not resulted from wall destruction, e.g. due to loss of opposite lung. C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C50685 Pallor Pallor An unusual or extreme paleness, state of decreased skin coloration. C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C50726 Regurgitation Regurgitation Flow in the opposite direction from normal, as the casting up of undigested food or gas from the stomach, or the backward flowing of blood into the heart, or between the chambers of the heart when a valve is incompetent. C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C50746 Sneezing Sneezing A symptom consisting of the involuntary expulsion of air from the nose. C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C61454 Basilar Rales Basilar Rales Abnormal breath sounds (crackles) heard on auscultation only in the bases of the lungs. They indicate inflammation, fluid, or infection in the air sacs of the lung. C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C78500 Nasal Congestion Nasal Congestion The blockage of the nasal passage due to mucosal edema. It is usually the result of a viral infection or an allergic reaction. C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C78718 Wheezing Wheezing A symptom and a finding during physical examination, characterized by a high-pitched, whistling sound during breathing. It results from the narrowing or obstruction of the respiratory airways. The most common causes of wheezing are asthma, chronic obstructive pulmonary disease, tracheobronchitis, and pulmonary edema. C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C87065 Cyanotic Body Cyanotic Body Blue- or purplish-colored body; this is caused by excessive amounts of deoxygenated hemoglobin in the skin vessels of the body. C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C87066 Cyanotic Limbs Cyanotic Limbs Blue- or purplish-colored limbs; this is caused by excessive amounts of deoxygenated hemoglobin in the skin vessels of the limbs. C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C87070 Hypotonia Hypotonia A condition of decreased tone of the skeletal muscles and diminished resistance to passive stretching. C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C87073 Excessive Sucking Excessive Sucking A symptom of gastrointestinal dysfunction seen in neonates who have been exposed to drugs during pregnancy; often accompanied by excessive sucking of fists, fingers and thumbs. C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C87085 Hypertonia Hypertonia A condition of increased muscle tone manifested by increased resistance of the muscle to passive stretching. C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C87087 Intercostal Retractions Intercostal Retractions The marked inward movement of the muscles between the ribs during inhalation; they indicate that there is reduced pressure in the chest cavity and can be a sign of breathing difficulties. C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C87089 Irregular Respiration Irregular Breathing A change from the normal breathing pattern in an infant, child, or adult, in terms of the amplitude and frequency of inhalations and exhalations. C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C87095 Mottling Mottling A patchy appearance of the skin caused by underlying blood vessel changes. C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C87096 Movement of Lip Corners Movement of Lip Corners During examination of the newborn infant, the examiner looks for symmetric movement of the lip corners. Movement of the lip corners is governed by the zygomatic major muscle. C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C87099 Nasal Flaring Nasal Flaring Enlargement of the nostrils during breathing; although there are many possible causes, it can be a sign of respiratory distress in young infants. C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C87111 Poor Feeding Poor Feeding Occurs either when an infant shows no interest in feeding or when there is an inability to take in adequate nutrition. Poor feeding is a nonspecific symptom of many disorders, including neurological, genetic, structural, metabolic, and infectious diseases. C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C87116 Rhonchi Rhonchi An abnormal sound similar to snoring heard on auscultation of the bronchial airways, suggesting a partial obstruction due to thick secretions, a muscular spasm, or a neoplasm. C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C87124 Central Nervous System Signs and Symptoms Central Nervous System Signs and Symptoms Signs and symptoms associated with disturbances within the central nervous system, which includes the brain, spinal cord and meninges. C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C87128 Watery Stool Watery Stool Frequent, loose, and watery stools are noted in most infants, even if they are fed formula, until they are six to eight weeks old; after that, the stools become firmer and less frequent. C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C87129 Weak Breathing Weak Breathing Shallow inhalations and exhalations that indicate respiratory distress. C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C87131 Yawning Yawning An involuntary deep inhalation with the mouth open, often a sign of drowsiness or boredom. C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C87169 High Pitched Cry High Pitched Cry A symptom in infants that could possibly indicate the presence of one of an array of medical conditions or congenital syndromes, including birth trauma, craniosynostosis, Arnold-Chiari deformity, meningitis, and cri-du-chat syndrome (deletion of the short arm of chromosome 5). C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C89888 Preterm Neonatal Stage Preterm Neonatal Stage The period at birth when a newborn is born prior to the full gestational period. A human life stage that begins at birth prior to thirty-seven weeks of full gestation (full term) and continues until twenty-seven complete days after birth. C89887 Neonatal Stage C90259 NICHD Pediatric Terminology C C92739 Back Labor Back Labor A type of labor where the labor pain or discomfort is felt by the pregnant mother in her back. C100104 Signs or Symptoms C90259 NICHD Pediatric Terminology C C92739 Back Labor Back Labor A type of labor where the labor pain or discomfort is felt by the pregnant mother in her back. C100104 Signs or Symptoms C92712 NICHD Pregnancy & Childbirth Terminology C C2987 Diarrhea Diarrhea A condition of frequent and watery bowel movements. C100104 Signs or Symptoms C96388 NICHD Childhood Immunization Terminology C C3038 Fever Fever The elevation of the body's temperature above the upper limit of normal, usually taken as 37.7 degrees C. C100104 Signs or Symptoms C96388 NICHD Childhood Immunization Terminology C C3114 Hypersensitivity Allergic Reaction A local or general reaction of an organism following contact with a specific allergen to which it has been previously exposed and to which it has become sensitized. C100104 Signs or Symptoms C96388 NICHD Childhood Immunization Terminology C C3303 Pain Pain The sensation of discomfort, distress, or agony, resulting from the stimulation of specialized nerve endings. C100104 Signs or Symptoms C96388 NICHD Childhood Immunization Terminology C C3442 Vomiting Vomiting The reflex act of ejecting the contents of the stomach through the mouth. C100104 Signs or Symptoms C96388 NICHD Childhood Immunization Terminology C C37928 Confusion Confusion A mental state characterized by a lack of clear and orderly thought and behavior. C100104 Signs or Symptoms C96388 NICHD Childhood Immunization Terminology C C39594 Skin Rash Skin Rash Any change in the skin which affects its appearance or texture. A rash may be localized to one part of the body, or affect all the skin. Rashes may cause the skin to change color, itch, become warm, bumpy, dry, cracked or blistered, swell and may be painful. C100104 Signs or Symptoms C96388 NICHD Childhood Immunization Terminology C C4077 Redness Redness Coloration of the skin; sign of inflammation C100104 Signs or Symptoms C96388 NICHD Childhood Immunization Terminology C C2962 Seizure Seizure Sudden, involuntary skeletal muscular contractions of cerebral or brain stem origin. C100104 Signs or Symptoms C97150 NICHD Neurological Development Terminology