D C14187 Bacteria Bacteria Unicellular, prokaryotic organisms that reproduce by cell division and usually have cell walls; can be shaped like spheres, rods or spirals and can be found in virtually any environment. C14250 Organism C96388 NICHD Childhood Immunization Terminology D C35470 Behavior-Related Disorder Behavioral Disorder A specific behavioral problem that occurs in persistent patterns and characteristic clusters and that causes clinically significant impairment. C2991 Disease or Disorder C96388 NICHD Childhood Immunization Terminology D C307 Biological Agent Biologic Agent Biotechnology-derived pharmaceutical agents made from living organisms or their products. Includes recombinant proteins, monoclonal antibodies, and nucleic acids. C1909 Pharmacologic Substance C96388 NICHD Childhood Immunization Terminology D C96412 Brain Developmental Abnormality Brain Development Abnormality A group of congenital or acquired disorders that affect the normal development of the brain. C89338 Neurodevelopmental Disorder C96388 NICHD Childhood Immunization Terminology D C96413 Brain Disorder Brain Disorder A non-neoplastic or neoplastic disorder that affects the brain. C2934 Central Nervous System Disorder C96388 NICHD Childhood Immunization Terminology D C2978 Cyst Cyst A sac-like closed membranous structure that may be empty or contain fluid or amorphous material. C2991 Disease or Disorder C96388 NICHD Childhood Immunization Terminology D C2991 Disease or Disorder Disease or Disorder Any abnormal condition of the body or mind that causes discomfort, dysfunction, or distress to the person affected or those in contact with the person. The term is often used broadly to include injuries, disabilities, syndromes, symptoms, deviant behaviors, and atypical variations of structure and function. C90259 NICHD Pediatric Terminology C96388 NICHD Childhood Immunization Terminology D C34632 Gastroenteritis Gastroenteritis An inflammatory disorder that affects the upper and lower gastrointestinal tract. Most commonly, this is attributed to viruses; however bacteria, parasites or adverse reactions can also be the culprit. Symptoms include acute diarrhea and vomiting. C2990 Gastrointestinal Disorder C96388 NICHD Childhood Immunization Terminology D C2990 Gastrointestinal Disorder Gastrointestinal Disorder A non-neoplastic or neoplastic disorder that affects the gastrointestinal tract, anus, liver, biliary system, and pancreas. C2991 Disease or Disorder C96388 NICHD Childhood Immunization Terminology D C35731 Hearing Loss Hearing Loss A partial or complete loss of hearing in one or both ears. It is classified as conductive, sensory, or central. C63711 Sensory Disorder C96388 NICHD Childhood Immunization Terminology D C26323 Hematologic and Lymphocytic Disorder Hematological Disorder A neoplastic or non-neoplastic disorder that affects the production and proliferation of the hematopoietic cells including lymphoid cells, the synthesis of hemoglobin, and/or the mechanisms of coagulation. C2991 Disease or Disorder C96388 NICHD Childhood Immunization Terminology D C28161 Intramuscular Route of Administration Intramuscular Route of Administration Intramuscular injection is a route of drug administration via injection into muscle tissue. Aqueous or oleaginous solutions and emulsions or suspensions may be administered. Absorption rates, delay in availability of the drug to the systemic circulation, and duration of effect are perfusion-limited, depend on molecular size of the agent, volume, and osmolarity of the drug solution, fat content of the injection site, and patient physical activity. C38291 Parenteral Route of Administration C96388 NICHD Childhood Immunization Terminology D C38276 Intravenous Route of Administration Intravenous Route of Administration Administration of a drug within or into a vein or veins. Introduction of the drug directly into venous circulation results in 100% bioavailability due to an absence of the absorption phase, provides a precise and continuous mode of drug therapy, especially for drugs with a narrow therapeutic index. C38291 Parenteral Route of Administration C96388 NICHD Childhood Immunization Terminology D C38284 Nasal Route of Administration Nasal Route of Administration Administration of a drug by the way of the nose. This often results in systemic action of the agent due to absorption through the nasal mucosa. The richly supplied vascular nature of the nasal mucosa coupled with its high drug permeation makes the nasal route of administration attractive for many drugs, including proteins and peptides. C38114 Route of Administration C96388 NICHD Childhood Immunization Terminology D C3262 Neoplasm Neoplasm A benign or malignant tissue growth resulting from uncontrolled cell proliferation. Benign neoplastic cells resemble normal cells without exhibiting significant cytologic atypia, while malignant cells exhibit overt signs such as dysplastic features, atypical mitotic figures, necrosis, nuclear pleomorphism, and anaplasia. Representative examples of benign neoplasms include papillomas, cystadenomas, and lipomas; malignant neoplasms include carcinomas, sarcomas, lymphomas, and leukemias. C2991 Disease or Disorder C96388 NICHD Childhood Immunization Terminology D C26835 Nervous System Disorder Neurologic Disorder A non-neoplastic or neoplastic disorder that affects the brain, spinal cord, or peripheral nerves. C2991 Disease or Disorder C96388 NICHD Childhood Immunization Terminology D C38288 Oral Route of Administration Oral Route of Administration The introduction of a substance to the mouth or into the gastrointestinal tract by the way of the mouth, usually for systemic action. It is the most common, convenient, and usually the safest and least expensive route of drug administration, but it uses the most complicated pathway to the tissues and bioavailability varies. The disadvantages of method are hepatic first pass metabolism and enzymatic degradation of the drug within the gastrointestinal tract. This prohibits oral administration of certain classes of drugs especially peptides and proteins. C38114 Route of Administration C96388 NICHD Childhood Immunization Terminology D C14250 Organism Organism A living entity. C90259 NICHD Pediatric Terminology C96388 NICHD Childhood Immunization Terminology D C38291 Parenteral Route of Administration Parenteral Route of Administration Administration of a substance by some means other than through the gastrointestinal tract: usually through injection, infusion, or implantation. Predominantly, the drug action is systemic, but in some cases, it is confined to local area. C38114 Route of Administration C96388 NICHD Childhood Immunization Terminology D C38114 Route of Administration Route of Administration Designation of the part of the body through which or into which, or the way in which, the medicinal product is intended to be introduced. In some cases a medicinal product can be intended for more than one route and/or method of administration. C16847 Technique C96388 NICHD Childhood Immunization Terminology D C2962 Seizure Seizure Sudden, involuntary skeletal muscular contractions of cerebral or brain stem origin. C4876 Symptom C96388 NICHD Childhood Immunization Terminology D C63711 Neurosensory Disorder Sensory Disorder An interruption or alteration in the sensory activity or functions of the nervous system. C2991 Disease or Disorder C96388 NICHD Childhood Immunization Terminology D C3364 Septicemia Sepsis The presence of pathogenic microorganisms in the blood stream causing a rapidly progressing systemic reaction that may lead to shock. Symptoms include fever, chills, tachycardia, and increased respiratory rate. It is a medical emergency that requires urgent medical attention. C2890 Bacterial Disease C96388 NICHD Childhood Immunization Terminology D C38299 Subcutaneous Route of Administration Subcutaneous Route of Administration Drug administration beneath the skin. It provides for relatively slow, sustained release of the drug. The rate of absorption into the blood is perfusion-limited, proportional to the amount of drug at the site and can be enhanced by chemical or physical stimulation of blood flow. Subcutaneous administration minimizes the risks associated with intravascular injection: for subcutaneous infusions, external and implantable pumps are used. C38291 Parenteral Route of Administration C96388 NICHD Childhood Immunization Terminology D C9229 Systemic Disease Systemic Disorder A clinical course finding indicating that a disease presents with systemic manifestations. C2991 Disease or Disorder C96388 NICHD Childhood Immunization Terminology D C14283 Virus Virus An infectious agent which consists of two parts, genetic material and a protein coat. These organisms lack independent metabolism, and they must infect the cells of other types of organisms to reproduce. Most viruses are capable of passing through fine filters that retain bacteria, and are not visible through a light microscope. C14250 Organism C96388 NICHD Childhood Immunization Terminology D C97167 Anemia of Prematurity Anemia of Prematurity A blood disorder characterized by low hemoglobin levels in premature neonates that usually spontaneously resolves within 3-6 months post birth. A combination of factors including the transition from the liver to the bone marrow for erythropoiesis in a neonate, blood loss experienced during delivery, the shortened life span of fetal blood cells, and an acclimation to a relatively hyperoxic environment outside the womb can predispose a neonate to this condition. C35729 Congenital Abnormality of the Circulatory System C97150 NICHD Neurological Development Terminology D C90599 Bronchopulmonary Dysplasia Bronchopulmonary Dysplasia A non-neoplastic lung disorder which develops in premature neonates who have been treated with oxygen and mechanical ventilation. C97173 Congenital Abnormality of the Respiratory System C97150 NICHD Neurological Development Terminology D C2931 Cardiovascular Disorder Cardiovascular Disorder A non-neoplastic or neoplastic disorder affecting the heart or the vessels (arteries, veins and lymph vessels). Representative examples of non-neoplastic cardiovascular disorders are endocarditis and hypertension. Representative examples of neoplastic cardiovascular disorders are endocardial myxoma and angiosarcoma. C2991 Disease or Disorder C97150 NICHD Neurological Development Terminology D C35729 Congenital Cardiovascular Abnormality Congenital Abnormality of the Circulatory System A heart or vascular abnormality which is inborn or present at birth. C2849 Congenital Abnormality C97150 NICHD Neurological Development Terminology D C97171 Congenital Gastrointestinal Disorder Congenital Abnormality of the Digestive System An abnormality of the digestive system that is present at birth or detected in the neonatal period. C2849 Congenital Abnormality C97150 NICHD Neurological Development Terminology D C89337 Congenital Musculoskeletal Defect Congenital Abnormality of the Musculoskeletal System An abnormality of the musculoskeletal system that is present at birth or detected in the neonatal period. C2849 Congenital Abnormality C97150 NICHD Neurological Development Terminology D C97173 Congenital Respiratory System Disorder Congenital Abnormality of the Respiratory System An abnormality of the respiratory system that is present at birth or detected in the neonatal period. C2849 Congenital Abnormality C97150 NICHD Neurological Development Terminology D C97174 Congenital Skin Disorder Congenital Abnormality of the Skin A skin abnormality that is present at birth or detected in the neonatal period. C2849 Congenital Abnormality C97150 NICHD Neurological Development Terminology D C42734 Contraceptive Device Contraceptive Device A device designed to prevent conception through local or systemic effect, such as a barrier contraceptive, an intrauterine device, or a means of preventing ovulation (e.g., birth control pill). C62103 Device C97150 NICHD Neurological Development Terminology D C3009 Endocrine Disorder Endocrine System Disorder Any deviation from the normal structure or function of the endocrine system that is manifested by a characteristic set of symptoms and signs. C2991 Disease or Disorder C97150 NICHD Neurological Development Terminology D C27020 Female Reproductive System Disorder Female Reproductive System Disorder A non-neoplastic or neoplastic disorder that affects the female genital system. Representative examples of non-neoplastic disorders include infection, endometriosis, and adenomyosis. Representative examples of neoplastic disorders include germ cell tumors, carcinoma, lymphoma, and sarcoma. C4875 Reproductive System Disorder C97150 NICHD Neurological Development Terminology D C15332 Gynecological Surgical Procedure Gynecologic Surgical Procedure Surgery performed on the female reproductive system. C15329 Surgical Procedure C97150 NICHD Neurological Development Terminology D C26323 Hematologic and Lymphocytic Disorder Hematological Disorder A neoplastic or non-neoplastic disorder that affects the production and proliferation of the hematopoietic cells including lymphoid cells, the synthesis of hemoglobin, and/or the mechanisms of coagulation. C2991 Disease or Disorder C97150 NICHD Neurological Development Terminology D C3507 Immune System Disorder Immunolymphatic System Disorder A disorder resulting from an abnormality in the immune system. -- 2003 C2991 Disease or Disorder C97150 NICHD Neurological Development Terminology D C3371 Skin Disorder Integumentary System Disorder Any deviation from the normal structure or function of the skin or subcutaneous tissue that is manifested by a characteristic set of symptoms and signs. C2991 Disease or Disorder C97150 NICHD Neurological Development Terminology D C27019 Male Reproductive System Disorder Male Reproductive System Disorder A non-neoplastic or neoplastic disorder that affects the male genital system. Representative examples of non-neoplastic disorders include infection, testicular torsion, and undescended testis. Representative examples of neoplastic disorders include germ cell tumors, carcinoma, lymphoma, and sarcoma. C4875 Reproductive System Disorder C97150 NICHD Neurological Development Terminology D C97176 Maternal Obesity Maternal Obesity Obesity in a female who has a child. C26836 Nutritional Disorder C97150 NICHD Neurological Development Terminology D C81182 Measurement Device Measurement Device Any device used to determine the dimension of an object. C62103 Device C97150 NICHD Neurological Development Terminology D C27574 Connective and Soft Tissue Disorder Musculoskeletal System Disorder Any deviation from the normal structure or function of the musculoskeletal or connective tissue that is manifested by a characteristic set of symptoms and signs. C2991 Disease or Disorder C97150 NICHD Neurological Development Terminology D C84915 Necrotizing Enterocolitis Necrotizing Enterocolitis A serious, life-threatening disorder characterized by necrotic changes affecting portions of the small and large intestine. It is usually seen in neonates, particularly premature infants. Signs and symptoms include abdominal distention and tenderness, intestinal bleeding and ileus. It may lead to cardiovascular collapse and shock. C97171 Congenital Abnormality of the Digestive System C97150 NICHD Neurological Development Terminology D C27560 Neonatal Respiratory Distress Syndrome Neonatal Respiratory Distress Syndrome A condition of the newborn marked by dyspnea with cyanosis, most frequently occurring in premature infants, children of diabetic mothers and infants delivered by cesarean section, and sometimes with no predisposing cause. C97173 Congenital Abnormality of the Respiratory System C97150 NICHD Neurological Development Terminology D C70856 Observation Result Observational Result An outcome of observation represented as a text, qualitative, or quantitative parameter, code, image, graph, etc. C3367 Finding C97150 NICHD Neurological Development Terminology D C4875 Reproductive System Disorder Reproductive System Disorder A non-neoplastic or neoplastic disorder that affects the male or female genital system. Representative examples of non-neoplastic disorders include infection, testicular torsion, endometriosis, and adenomyosis. Representative examples of neoplastic disorders include germ cell tumors, carcinoma, lymphoma, and sarcoma. C2991 Disease or Disorder C97150 NICHD Neurological Development Terminology D C15429 Research Activity Research Activity Systematic investigation into a subject in order to discover facts, establish or revise a theory, or develop a plan of action based on the facts discovered. C16205 Healthcare Activity C97150 NICHD Neurological Development Terminology D C27561 Respiratory Distress Syndrome Respiratory Distress Syndrome A group of conditions characterized by failure of normal respiration caused by lack of lung surfactant. C26871 Respiratory System Disorder C97150 NICHD Neurological Development Terminology D C26871 Respiratory Disorder Respiratory System Disorder A non-neoplastic or neoplastic disorder that affects the tracheobronchial tree and/or the lung parenchyma. Representative examples include infections, carcinomas, and lymphomas. C2991 Disease or Disorder C97150 NICHD Neurological Development Terminology D C34982 Retrolental Fibroplasia Retinopathy of Prematurity A bilateral retinopathy characterized by neovascularization, scarring, retinal detachment, and eventually blindness. It may be mild or severe. It occurs in babies born prematurely. Causes include oxygen toxicity and hypoxia. C97172 Congenital Abnormality of the Nervous System C97150 NICHD Neurological Development Terminology D C15329 Surgical Procedure Surgical Procedure A diagnostic or treatment procedure performed by manual and/or instrumental means, often involving an incision and the removal or replacement of a diseased organ or tissue; of or relating to or involving or used in surgery or requiring or amenable to treatment by surgery. C25218 Intervention or Procedure C97150 NICHD Neurological Development Terminology D C97151 Systemic Congenital Disorder Systemic Congenital Disorder An inherited disorder that presents with systemic manifestations. C2849 Congenital Abnormality C97150 NICHD Neurological Development Terminology D C15843 Preventive Intervention Preventive Intervention Therapeutic, nutritional, environmental, social and or behavioral interventions at the societal, community, organizational or individual levels to reduce, modify or stop the course of a disease. C25218 Intervention or Procedure C89506 NICHD Newborn Screening Terminology D C92722 Qualitative Qualitative Concept A measurement expressed in words rather than numbers. C20189 Property or Attribute C92712 NICHD Pregnancy & Childbirth Terminology D C70766 Quantitative Quantitative Concept Capable of being estimated or expressed with numeric values. C20189 Property or Attribute C92712 NICHD Pregnancy & Childbirth Terminology A C2962 Seizure Seizure Sudden, involuntary skeletal muscular contractions of cerebral or brain stem origin. C4876 Symptom C97150 NICHD Neurological Development Terminology A C97167 Anemia of Prematurity Anemia of Prematurity A blood disorder characterized by low hemoglobin levels in premature neonates that usually spontaneously resolves within 3-6 months post birth. A combination of factors including the transition from the liver to the bone marrow for erythropoiesis in a neonate, blood loss experienced during delivery, the shortened life span of fetal blood cells, and an acclimation to a relatively hyperoxic environment outside the womb can predispose a neonate to this condition. C35729 Congenital Abnormality of the Circulatory System C92712 NICHD Pregnancy & Childbirth Terminology A C90599 Bronchopulmonary Dysplasia Bronchopulmonary Dysplasia A non-neoplastic lung disorder which develops in premature neonates who have been treated with oxygen and mechanical ventilation. C97173 Congenital Abnormality of the Respiratory System C92712 NICHD Pregnancy & Childbirth Terminology A C15332 Gynecological Surgical Procedure Gynecologic Surgical Procedure Surgery performed on the female reproductive system. C15329 Surgical Procedure C92712 NICHD Pregnancy & Childbirth Terminology A C97176 Maternal Obesity Maternal Obesity Obesity in a female who has a child. C26836 Nutritional Disorder C92712 NICHD Pregnancy & Childbirth Terminology A C81182 Measurement Device Measurement Device Any device used to determine the dimension of an object. C62103 Device C92712 NICHD Pregnancy & Childbirth Terminology A C84915 Necrotizing Enterocolitis Necrotizing Enterocolitis A serious, life-threatening disorder characterized by necrotic changes affecting portions of the small and large intestine. It is usually seen in neonates, particularly premature infants. Signs and symptoms include abdominal distention and tenderness, intestinal bleeding and ileus. It may lead to cardiovascular collapse and shock. C97171 Congenital Abnormality of the Digestive System C92712 NICHD Pregnancy & Childbirth Terminology A C27560 Neonatal Respiratory Distress Syndrome Neonatal Respiratory Distress Syndrome A condition of the newborn marked by dyspnea with cyanosis, most frequently occurring in premature infants, children of diabetic mothers and infants delivered by cesarean section, and sometimes with no predisposing cause. C97173 Congenital Abnormality of the Respiratory System C92712 NICHD Pregnancy & Childbirth Terminology A C27561 Respiratory Distress Syndrome Respiratory Distress Syndrome A group of conditions characterized by failure of normal respiration caused by lack of lung surfactant. C26871 Respiratory System Disorder C92712 NICHD Pregnancy & Childbirth Terminology