Changes: Changes for the month of February. The format of the spreadsheet has been modified to contain one subset column. A concept may be in more than one subset. Most of these definitions differ only for the current presence of quotation marks around the terms that were omitted in the previous version. The definition for Oxytocin has been modified to concur with our new template for hormone and gene definitions. Modified Definitions: NCIt Code NCIt PT NICHD PT NICHD SY NCIt Definition NCIt Code of NICHD Parent NICHD Parent PT NCIt Code of NICHD Parent NICHD Parent PT NCIt Code of NICHD Subset NICHD PT of NICHD Subset C2283 Oxytocin Oxytocin Oxytocin (125 aa, ~13kDa) is encoded by the human OXT gene. This protein plays a role in smooth muscle contraction in both the mammary gland and uterus. Oxytocin also is involved in maternal-newborn bonding, cognition and many other psychological and physiological processes. C13236 Biological Substance C92712 NICHD Pregnancy & Childbirth Terminology C89516 Neuromuscular Maturity Assessment Neuromuscular Maturity Assessment An examination of the following neonatal attributes: 1) posture; 2) the "square window" (how far the baby's hands can be flexed toward the wrist); 3) arm recoil; 4) "popliteal angle" (how far the baby's knees extend); 5) "scarf sign" (how far the baby's elbows can be moved across the chest); and 6) "heel to ear" (how far the baby's feet can be moved to the ears). It is a subscore of the Dubowitz/Ballard Examination for Gestational Age. C20993 Clinical Assessment Tool C89506 NICHD Newborn Screening Terminology C89520 Square Window Square Window When testing the newborn infant for neuromuscular maturity, the "square window" test measures wrist flexibility and resistance to extensor stretching, The examiner straightens the infant's fingers and applies gentle pressure on the dorsum of the hand, close to the fingers, and then estimates the angle between the palm of the hand and the forearm. C20993 Clinical Assessment Tool C89506 NICHD Newborn Screening Terminology C89521 Scarf Sign Scarf Sign When testing the newborn infant for neuromuscular maturity, the "scarf sign" test is carried out by drawing the newborn's arm across the chest to the opposite shoulder until resistance is felt. In term infants, the elbow should not cross the midline of the chest. C20993 Clinical Assessment Tool C89506 NICHD Newborn Screening Terminology C943 Vitamin K Vitamin K The term "vitamin K" refers to a group of chemically similar fat-soluble compounds called naphthoquinones: vitamin K1 (phytonadione) is found in plants and is the primary source of vitamin K for humans through dietary consumption, vitamin K2 compounds (menaquinones) are made by bacteria in the human gut, and vitamin K3 (menadione) is a water-soluble preparation available for adults only. Vitamin K is necessary for the liver to produce the coagulation factors II, VII, IX, and X, as well as the clotting factors protein C, protein S, and protein Z; vitamin K deficiency can result in deficiencies of these coagulation factors and excess bleeding. An injection of vitamin K is routinely given to newborn infants to prevent vitamin K deficiency bleeding, also known as hemorrhagic disease of the newborn. Vitamin K deficiency is rare in adults but may result from chronic malnutrition or an inability to absorb dietary vitamins. C45306 Substance C89506 NICHD Newborn Screening Terminology C2283 Oxytocin Oxytocin Oxytocin (125 aa, ~13kDa) is encoded by the human OXT gene. This protein plays a role in smooth muscle contraction in both the mammary gland and uterus. Oxytocin also is involved in maternal-newborn bonding, cognition and many other psychological and physiological processes. C13236 Biological Substance C90259 NICHD Pediatric Terminology C89516 Neuromuscular Maturity Assessment Neuromuscular Maturity Assessment An examination of the following neonatal attributes: 1) posture; 2) the "square window" (how far the baby's hands can be flexed toward the wrist); 3) arm recoil; 4) "popliteal angle" (how far the baby's knees extend); 5) "scarf sign" (how far the baby's elbows can be moved across the chest); and 6) "heel to ear" (how far the baby's feet can be moved to the ears). It is a subscore of the Dubowitz/Ballard Examination for Gestational Age. C20993 Clinical Assessment Tool C90259 NICHD Pediatric Terminology C89520 Square Window Square Window When testing the newborn infant for neuromuscular maturity, the "square window" test measures wrist flexibility and resistance to extensor stretching, The examiner straightens the infant's fingers and applies gentle pressure on the dorsum of the hand, close to the fingers, and then estimates the angle between the palm of the hand and the forearm. C20993 Clinical Assessment Tool C90259 NICHD Pediatric Terminology C89521 Scarf Sign Scarf Sign When testing the newborn infant for neuromuscular maturity, the "scarf sign" test is carried out by drawing the newborn's arm across the chest to the opposite shoulder until resistance is felt. In term infants, the elbow should not cross the midline of the chest. C20993 Clinical Assessment Tool C90259 NICHD Pediatric Terminology C90342 Developmental Milestone Developmental Milestones Physical or behavioral signs of maturation or skills gained by a developing child, which should be achieved by a given age that provide important information regarding the child's development. The milestones are different for each age range. Failure to achieve a particular milestone by a given age is indicative of developmental delay. C20993 Clinical Assessment Tool C90259 NICHD Pediatric Terminology C943 Vitamin K Vitamin K The term "vitamin K" refers to a group of chemically similar fat-soluble compounds called naphthoquinones: vitamin K1 (phytonadione) is found in plants and is the primary source of vitamin K for humans through dietary consumption, vitamin K2 compounds (menaquinones) are made by bacteria in the human gut, and vitamin K3 (menadione) is a water-soluble preparation available for adults only. Vitamin K is necessary for the liver to produce the coagulation factors II, VII, IX, and X, as well as the clotting factors protein C, protein S, and protein Z; vitamin K deficiency can result in deficiencies of these coagulation factors and excess bleeding. An injection of vitamin K is routinely given to newborn infants to prevent vitamin K deficiency bleeding, also known as hemorrhagic disease of the newborn. Vitamin K deficiency is rare in adults but may result from chronic malnutrition or an inability to absorb dietary vitamins. C45306 Substance C90259 NICHD Pediatric Terminology