April 2024 MED-RT (version name 2024.04.01)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2024.03.11)

	RxNorm (2024.03.04.23AB)

	MeSH (2024_2024.01.01)

	SNOMED CT US Edition (2024.03.23AB)

	UMLS Metathesaurus (2023AB)



TOTAL CONCEPTS IN PREVIOUS VERSION (2024.03.04): 3574

TOTAL CONCEPTS IN CURRENT VERSION (2024.04.01): 3574

	EPC concepts: 731

	APC concepts: 44	

	MoA concepts: 745

	PE concepts:  1871

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 27

	HC concepts:  31



------------------------------------------------------------------------------------------

March 2024 MED-RT (version name 2024.03.04)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2023.12.05)

	RxNorm (2024.02.05.23AB)

	MeSH (2024_2024.01.01)

	SNOMED CT US Edition (2023.09.23AA)

	UMLS Metathesaurus (2023AB)



TOTAL CONCEPTS IN PREVIOUS VERSION (2024.02.05): 3574

TOTAL CONCEPTS IN CURRENT VERSION (2024.03.04): 3574

	EPC concepts: 731

	APC concepts: 44	

	MoA concepts: 745

	PE concepts:  1871

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 27

	HC concepts:  31



------------------------------------------------------------------------------------------

February 2024 MED-RT (version name 2024.02.05)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2023.12.05)

	RxNorm (2024.01.02.23AB)

	MeSH (2024_2024.01.01)

	SNOMED CT US Edition (2023.09.23AA)

	UMLS Metathesaurus (2023AB)



TOTAL CONCEPTS IN PREVIOUS VERSION (2024.01.02): 3561

TOTAL CONCEPTS IN CURRENT VERSION (2024.02.05): 3574

	EPC concepts: 731

	APC concepts: 44	

	MoA concepts: 745

	PE concepts:  1871

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 27

	HC concepts:  31



There were 13 new concepts manually added for this release including 5 added to Established Pharmacologic Classes and 8 added to the Mechanism of Action hierarchy.



------------------------------------------------------------------------------------------

December/January 2024 MED-RT (version name 2024.01.02)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2023.12.05)

	RxNorm (2023.12.04.23AB)

	MeSH (2023_2023.07.01)

	SNOMED CT US Edition (2023.09.23AA)

	UMLS Metathesaurus (2023AB)



TOTAL CONCEPTS IN PREVIOUS VERSION (2023.11.06): 3551

TOTAL CONCEPTS IN CURRENT VERSION (2024.01.02): 3561

	EPC concepts: 726

	APC concepts: 44	

	MoA concepts: 737

	PE concepts:  1871

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 27

	HC concepts:  31



There were 10 new concepts manually added for this release including 8 added to Established Pharmacologic Classes and 2 added to the Mechanism of Action hierarchy.



------------------------------------------------------------------------------------------

November 2023 MED-RT (version name 2023.11.06)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2023.10.04)

	RxNorm (2023.10.02.23AA)

	MeSH (2023_2023.07.01)

	SNOMED CT US Edition (2023.09.23AA)

	UMLS Metathesaurus (2023AA)



TOTAL CONCEPTS IN PREVIOUS VERSION (2023.10.02): 3542

TOTAL CONCEPTS IN CURRENT VERSION (2023.11.06): 3551

	EPC concepts: 718

	APC concepts: 44	

	MoA concepts: 735

	PE concepts:  1871

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 27

	HC concepts:  31



There were 9 new concepts manually added for this release including 5 added to Established Pharmacologic Classes, 3 added to Additional Pharmacologic Classes, and 1 added to the Terminology Extensions for Classification hierarchy.



------------------------------------------------------------------------------------------

October 2023 MED-RT (version name 2023.10.02)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2023.08.17)

	RxNorm (2023.09.05.23AA)

	MeSH (2023_2023.07.01)

	SNOMED CT US Edition (2023.09.23AA)

	UMLS Metathesaurus (2023AA)



TOTAL CONCEPTS IN PREVIOUS VERSION (2023.09.05): 3538

TOTAL CONCEPTS IN CURRENT VERSION (2023.10.02): 3542

	EPC concepts: 713

	APC concepts: 41	

	MoA concepts: 735

	PE concepts:  1871

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 26

	HC concepts:  31



There were 4 new concepts manually added for this release including 1 added to Established Pharmacologic Classes and 3 added to the Mechanism of Action hierarchy.

 

------------------------------------------------------------------------------------------

August/September 2023 MED-RT (version name 2023.09.05)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2023.08.17)

	RxNorm (2023.08.07.23AA)

	MeSH (2023_2023.07.01)

	SNOMED CT US Edition (2023.03.22AB)

	UMLS Metathesaurus (2023AA)



TOTAL CONCEPTS IN PREVIOUS VERSION (2023.07.03): 3524

TOTAL CONCEPTS IN CURRENT VERSION (2023.09.05): 3538

	EPC concepts: 712

	APC concepts: 41	

	MoA concepts: 732

	PE concepts:  1871

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 26

	HC concepts:  31



There were 14 new concepts manually added for this release including 6 added to Established Pharmacologic Classes and 8 added to the Mechanism of Action hierarchy.

 

------------------------------------------------------------------------------------------

July 2023 MED-RT (version name 2023.07.03)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2023.05.29)

	RxNorm (2023.06.05.23AA)

	MeSH (2023_2023.01.01)

	SNOMED CT US Edition (2023.03.22AB)

	UMLS Metathesaurus (2023AA)



TOTAL CONCEPTS IN PREVIOUS VERSION (2023.06.05): 3516

TOTAL CONCEPTS IN CURRENT VERSION (2023.07.03): 3524

	EPC concepts: 706

	APC concepts: 41	

	MoA concepts: 724

	PE concepts:  1871

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 26

	HC concepts:  31



There were 8 new concepts manually added for this release including 4 added to Established Pharmacologic Classes and 4 added to the Mechanism of Action hierarchy.

 

------------------------------------------------------------------------------------------

June 2023 MED-RT (version name 2023.06.05)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2023.05.17)

	RxNorm (2023.05.01.23AA)

	MeSH (2023_2023.01.01)

	SNOMED CT US Edition (2023.03.22AB)

	UMLS Metathesaurus (2023AA)



TOTAL CONCEPTS IN PREVIOUS VERSION (2023.05.01): 3501

TOTAL CONCEPTS IN CURRENT VERSION (2023.06.05): 3516

	EPC concepts: 702

	APC concepts: 41	

	MoA concepts: 720

	PE concepts:  1871

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 26

	HC concepts:  31



There were 15 new concepts manually added for this release including 7 added to Established Pharmacologic Classes and 8 added to the Mechanism of Action hierarchy.

 

------------------------------------------------------------------------------------------

May 2023 MED-RT (version name 2023.05.01)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2023.04.20)

	RxNorm (2023.04.03.22AB)

	MeSH (2023_2023.01.01)

	SNOMED CT US Edition (2023.03.22AB)

	UMLS Metathesaurus (2022AB)



TOTAL CONCEPTS IN PREVIOUS VERSION (2023.04.03): 3501

TOTAL CONCEPTS IN CURRENT VERSION (2023.05.01): 3501

	EPC concepts: 695

	APC concepts: 41	

	MoA concepts: 712

	PE concepts:  1871

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 26

	HC concepts:  31

 

------------------------------------------------------------------------------------------

April 2023 MED-RT (version name 2023.04.03)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2023.02.07)

	RxNorm (2023.03.06.22AB)

	MeSH (2023_2023.01.01)

	SNOMED CT US Edition (2023.03.22AB)

	UMLS Metathesaurus (2022AB)



TOTAL CONCEPTS IN PREVIOUS VERSION (2023.03.06): 3500

TOTAL CONCEPTS IN CURRENT VERSION (2023.04.03): 3501

	EPC concepts: 695

	APC concepts: 41	

	MoA concepts: 712

	PE concepts:  1871

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 26

	HC concepts:  31



There was 1 new concept manually added to the Established Pharmacologic Classes hierarchy for this release. 

------------------------------------------------------------------------------------------

March 2023 MED-RT (version name 2023.03.06)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2023.02.07)

	RxNorm (2023.02.06.22AB)

	MeSH (2023_2023.01.01)

	SNOMED CT US Edition (2022.09.22AA)

	UMLS Metathesaurus (2022AB)



TOTAL CONCEPTS IN PREVIOUS VERSION (2023.02.06): 3495

TOTAL CONCEPTS IN CURRENT VERSION (2023.03.06): 3500

	EPC concepts: 694

	APC concepts: 41	

	MoA concepts: 712

	PE concepts:  1871

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 26

	HC concepts:  31



There were 5 new concepts manually added for this release including 3 added to Established Pharmacologic Classes and 2 added to the Mechanism of Action hierarchy.



------------------------------------------------------------------------------------------

February 2023 MED-RT (version name 2023.02.06)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2023.01.16)

	RxNorm (2023.01.03.22AB)

	MeSH (2023_2023.01.01)

	SNOMED CT US Edition (2022.09.22AA)

	UMLS Metathesaurus (2022AB)



TOTAL CONCEPTS IN PREVIOUS VERSION (2023.01.03): 3490

TOTAL CONCEPTS IN CURRENT VERSION (2023.02.06): 3495

	EPC concepts: 691

	APC concepts: 41	

	MoA concepts: 710

	PE concepts:  1871

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 26

	HC concepts:  31



There were 5 new concepts manually added for this release including 4 added to Established Pharmacologic Classes and 1 added to the Mechanism of Action hierarchy.



------------------------------------------------------------------------------------------



December/January 2023 MED-RT (version name 2023.01.03)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2022.09.05)

	RxNorm (2022.12.05.22AB)

	MeSH (2022_2022.07.01)

	SNOMED CT US Edition (2022.09.22AA)

	UMLS Metathesaurus (2022AB)



TOTAL CONCEPTS IN PREVIOUS VERSION (2022.11.07): 3490

TOTAL CONCEPTS IN CURRENT VERSION (2023.01.03): 3490

	EPC concepts: 687

	APC concepts: 41	

	MoA concepts: 709

	PE concepts:  1871

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 26

	HC concepts:  31



------------------------------------------------------------------------------------------



November 2022 MED-RT (version name 2022.11.07)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2022.09.05)

	RxNorm (2022.10.03.22AA)

	MeSH (2022_2022.07.01)

	SNOMED CT US Edition (2022.09.22AA)

	UMLS Metathesaurus (2022AA)



TOTAL CONCEPTS IN PREVIOUS VERSION (2022.10.03): 3490

TOTAL CONCEPTS IN CURRENT VERSION (2022.11.07): 3490

	EPC concepts: 687

	APC concepts: 41	

	MoA concepts: 709

	PE concepts:  1871

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 26

	HC concepts:  31



------------------------------------------------------------------------------------------

October 2022 MED-RT (version name 2022.10.03)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2022.09.05)

	RxNorm (2022.09.06.22AA)

	MeSH (2022_2022.07.01)

	SNOMED CT US Edition (2022.09.22AA)

	UMLS Metathesaurus (2022AA)



TOTAL CONCEPTS IN PREVIOUS VERSION (2022.09.06): 3490

TOTAL CONCEPTS IN CURRENT VERSION (2022.10.03): 3490

	EPC concepts: 687

	APC concepts: 41	

	MoA concepts: 709

	PE concepts:  1871

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 26

	HC concepts:  31



------------------------------------------------------------------------------------------



August/September 2022 MED-RT (version name 2022.09.06)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2022.08.08)

	RxNorm (2022.08.01.22AA)

	MeSH (2022_2022.07.01)

	SNOMED CT US Edition (2022.03.21AB)

	UMLS Metathesaurus (2022AA)



TOTAL CONCEPTS IN PREVIOUS VERSION (2022.07.05): 3489

TOTAL CONCEPTS IN CURRENT VERSION (2022.09.06): 3490

	EPC concepts: 687

	APC concepts: 41	

	MoA concepts: 709

	PE concepts:  1871

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 26

	HC concepts:  31



There was 1 Additional Pharmacologic Class (APC) concept added manually for this release.



------------------------------------------------------------------------------------------

July 2022 MED-RT (version name 2022.07.05)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2022.05.06)

	RxNorm (2022.06.06.22AA)

	MeSH (2022_2022.01.01)

	SNOMED CT US Edition (2022.03.21AB)

	UMLS Metathesaurus (2022AA)



TOTAL CONCEPTS IN PREVIOUS VERSION (2022.06.06): 3489

TOTAL CONCEPTS IN CURRENT VERSION (2022.07.05): 3489

	EPC concepts: 687

	APC concepts: 40	

	MoA concepts: 709

	PE concepts:  1871

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 26

	HC concepts:  31



------------------------------------------------------------------------------------------

June 2022 MED-RT (version name 2022.06.06)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2022.05.06)

	RxNorm (2022.05.02.22AA)

	MeSH (2022_2022.01.01)

	SNOMED CT US Edition (2022.03.21AB)

	UMLS Metathesaurus (2022AA)



TOTAL CONCEPTS IN PREVIOUS VERSION (2022.05.02): 3489

TOTAL CONCEPTS IN CURRENT VERSION (2022.06.06): 3489

	EPC concepts: 687

	APC concepts: 40	

	MoA concepts: 709

	PE concepts:  1871

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 26

	HC concepts:  31



------------------------------------------------------------------------------------------

May 2022 MED-RT (version name 2022.05.02)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2022.04.08)

	RxNorm (2022.04.04.21AB)

	MeSH (2022_2022.01.01)

	SNOMED CT US Edition (2022.03.21AB)

	UMLS Metathesaurus (2021AB)



TOTAL CONCEPTS IN PREVIOUS VERSION (2022.04.04): 3472

TOTAL CONCEPTS IN CURRENT VERSION (2022.05.02): 3489

	EPC concepts: 687

	APC concepts: 40	

	MoA concepts: 709

	PE concepts:  1871

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 26

	HC concepts:  31





There were 17 new concepts manually added for this release including 7 added to Established Pharmacologic Classes, 9 added to the Mechanism of Action hierarchy and 1 added to the Physiological Effects hierarchy.



------------------------------------------------------------------------------------------

April 2022 MED-RT (version name 2022.04.04)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2022.03.23)

	RxNorm (2022.03.07.21AB)

	MeSH (2022_2022.01.01)

	SNOMED CT US Edition (2022.03.21AB)

	UMLS Metathesaurus (2021AB)



TOTAL CONCEPTS IN PREVIOUS VERSION (2022.03.07): 3466

TOTAL CONCEPTS IN CURRENT VERSION (2022.04.04): 3472

	EPC concepts: 680

	APC concepts: 40	

	MoA concepts: 700

	PE concepts:  1870

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 26

	HC concepts:  31





There were 6 new concepts manually added for this release including 3 added to Established Pharmacologic Classes and 3 added to the Mechanism of Action hierarchy.



------------------------------------------------------------------------------------------

March 2022 MED-RT (version name 2022.03.07)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2022.02.11)

	RxNorm (2022.02.07.21AB)

	MeSH (2022_2022.01.01)

	SNOMED CT US Edition (2021.09.21AA)

	UMLS Metathesaurus (2021AB)



TOTAL CONCEPTS IN PREVIOUS VERSION (2022.02.07): 3461

TOTAL CONCEPTS IN CURRENT VERSION (2022.03.07): 3466

	EPC concepts: 677

	APC concepts: 40	

	MoA concepts: 697

	PE concepts:  1870

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 26

	HC concepts:  31





There were 5 new concepts manually added for this release including 2 added to Established Pharmacologic Classes and 3 added to the Mechanism of Action hierarchy.



------------------------------------------------------------------------------------------

February 2022 MED-RT (version name 2022.02.07)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2022.01.24)

	RxNorm (2022.01.03.21AB)

	MeSH (2022_2022.01.01)

	SNOMED CT US Edition (2021.09.21AA)

	UMLS Metathesaurus (2021AB)



TOTAL CONCEPTS IN PREVIOUS VERSION (2022.01.03): 3457

TOTAL CONCEPTS IN CURRENT VERSION (2022.02.07): 3461

	EPC concepts: 675

	APC concepts: 40	

	MoA concepts: 694

	PE concepts:  1870

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 26

	HC concepts:  31





There were 4 new concepts manually added for this release including 3 added to Established Pharmacologic Classes and 1 added to the Mechanism of Action hierarchy.



------------------------------------------------------------------------------------------

December/January 2022 MED-RT (version name 2022.01.03)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2021.12.08)

	RxNorm (2021.12.06.21AB)

	MeSH (2021_2021.07.01)

	SNOMED CT US Edition (2021.09.21AA)

	UMLS Metathesaurus (2021AB)



TOTAL CONCEPTS IN PREVIOUS VERSION (2021.11.01): 3448

TOTAL CONCEPTS IN CURRENT VERSION (2022.01.03): 3457

	EPC concepts: 672

	APC concepts: 40	

	MoA concepts: 693

	PE concepts:  1870

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 26

	HC concepts:  31





There were 9 new concepts manually added for this release including 3 added to Established Pharmacologic Classes, 4 added to the Mechanism of Action hierarchy and 2 added to the Physiological Effects hierarchy.



------------------------------------------------------------------------------------------

November 2021 MED-RT (version name 2021.11.01)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2021.09.07)

	RxNorm (2021.10.04.21AA)

	MeSH (2021_2021.07.01)

	SNOMED CT US Edition (2021.09.21AA)

	UMLS Metathesaurus (2021AA)



TOTAL CONCEPTS IN PREVIOUS VERSION (2021.10.04): 3446

TOTAL CONCEPTS IN CURRENT VERSION (2021.11.01): 3448

	EPC concepts: 669

	APC concepts: 40	

	MoA concepts: 689

	PE concepts:  1868

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 26

	HC concepts:  31



------------------------------------------------------------------------------------------

October 2021 MED-RT (version name 2021.10.04)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2021.09.07)

	RxNorm (2021.09.07.21AA)

	MeSH (2021_2021.07.01)

	SNOMED CT US Edition (2021.09.21AA)

	UMLS Metathesaurus (2021AA)



TOTAL CONCEPTS IN PREVIOUS VERSION (2021.09.07): 3446

TOTAL CONCEPTS IN CURRENT VERSION (2021.10.04): 3446

	EPC concepts: 666

	APC concepts: 41	

	MoA concepts: 689

	PE concepts:  1868

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 26

	HC concepts:  31



------------------------------------------------------------------------------------------

August/September 2021 MED-RT (version name 2021.09.07)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2021.08.24)

	RxNorm (2021.08.02.21AA)

	MeSH (2021_2021.07.01)

	SNOMED CT US Edition (2021.03.20AB)

	UMLS Metathesaurus (2021AA)



TOTAL CONCEPTS IN PREVIOUS VERSION (2021.07.06): 3426

TOTAL CONCEPTS IN CURRENT VERSION (2021.09.07): 3446

	EPC concepts: 666

	APC concepts: 41	

	MoA concepts: 689

	PE concepts:  1868

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 26

	HC concepts:  31



There were 20 new concepts manually added for this release including 9 added to Established Pharmacologic Classes and 11 added to the Mechanism of Action hierarchy.



------------------------------------------------------------------------------------------

July 2021 MED-RT (version name 2021.07.06)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2021.06.15)

	RxNorm (2021.06.07.21AA)

	MeSH (2021_2021.01.01)

	SNOMED CT US Edition (2021.03.20AB)

	UMLS Metathesaurus (2021AA)



TOTAL CONCEPTS IN PREVIOUS VERSION (2021.06.07): 3411

TOTAL CONCEPTS IN CURRENT VERSION (2021.07.06): 3426

	EPC concepts: 657

	APC concepts: 41	

	MoA concepts: 678

	PE concepts:  1868

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 26

	HC concepts:  31



There were 15 new concepts manually added for this release including 4 added to Established Pharmacologic Classes, 1 added to Additional Pharmacologic Classes, and 10 added to the Mechanism of Action hierarchy.



------------------------------------------------------------------------------------------



June 2021 MED-RT (version name 2021.06.07)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2020.07.22)

	RxNorm (2021.05.03.21AA)

	MeSH (2021_2021.01.01)

	SNOMED CT US Edition (2021.03.20AB)

	UMLS Metathesaurus (2021AA)



TOTAL CONCEPTS IN PREVIOUS VERSION (2021.05.03): 3392

TOTAL CONCEPTS IN CURRENT VERSION (2021.06.07): 3411

	EPC concepts: 653

	APC concepts: 40	

	MoA concepts: 668

	PE concepts:  1868

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 26

	HC concepts:  31



There were 19 new concepts manually added for this release including 5 added to Established Pharmacologic Classes, 13 added to the Mechanism of Action hierarchy, and 1 added to the Terminology Extensions for Classification hierarchy.



------------------------------------------------------------------------------------------

May 2021 MED-RT (version name 2021.05.03)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2020.07.22)

	RxNorm (2021.04.05.20AB)

	MeSH (2021_2021.01.01)

	SNOMED CT US Edition (2021.03.20AB)

	UMLS Metathesaurus (2020AB)



TOTAL CONCEPTS IN PREVIOUS VERSION (2021.04.05): 3392

TOTAL CONCEPTS IN CURRENT VERSION (2021.05.03): 3392

	EPC concepts: 648

	APC concepts: 40	

	MoA concepts: 655

	PE concepts:  1868

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 25

	HC concepts:  31



------------------------------------------------------------------------------------------

April 2021 MED-RT (version name 2021.04.05)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2020.07.22)

	RxNorm (2021.03.01.20AB)

	MeSH (2021_2021.01.01)

	SNOMED CT US Edition (2021.03.20AB)

	UMLS Metathesaurus (2020AB)



TOTAL CONCEPTS IN PREVIOUS VERSION (2021.03.01): 3392

TOTAL CONCEPTS IN CURRENT VERSION (2021.04.05): 3392

	EPC concepts: 648

	APC concepts: 40	

	MoA concepts: 655

	PE concepts:  1868

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 25

	HC concepts:  31



------------------------------------------------------------------------------------------

March 2021 MED-RT (version name 2021.03.01)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2020.07.22)

	RxNorm (2021.02.01.20AB)

	MeSH (2021_2021.01.01)

	SNOMED CT US Edition (2020.09.20AA)

	UMLS Metathesaurus (2020AB)



TOTAL CONCEPTS IN PREVIOUS VERSION (2021.02.01): 3392

TOTAL CONCEPTS IN CURRENT VERSION (2021.03.01): 3392

	EPC concepts: 648

	APC concepts: 40	

	MoA concepts: 655

	PE concepts:  1868

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 25

	HC concepts:  31



------------------------------------------------------------------------------------------



February 2021 MED-RT (version name 2021.02.01)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2020.07.22)

	RxNorm (2021.01.04.20AB)

	MeSH (2021_2021.01.01)

	SNOMED CT US Edition (2020.09.20AA)

	UMLS Metathesaurus (2020AB)



TOTAL CONCEPTS IN PREVIOUS VERSION (2021.01.04): 3390

TOTAL CONCEPTS IN CURRENT VERSION (2021.02.01): 3392

	EPC concepts: 648

	APC concepts: 40	

	MoA concepts: 655

	PE concepts:  1868

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 25

	HC concepts:  31



There were 2 new concepts manually added for this release including 1 added to Established Pharmacologic Classes and 1 added to the Mechanism of Action hierarchy.



------------------------------------------------------------------------------------------



December/January 2021 MED-RT (version name 2021.01.04)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2020.07.22)

	RxNorm (2020.12.07.20AB)

	MeSH (2020_2020.07.01)

	SNOMED CT US Edition (2020.09.20AA)

	UMLS Metathesaurus (2020AB)



TOTAL CONCEPTS IN PREVIOUS VERSION (2020.11.02): 3390

TOTAL CONCEPTS IN CURRENT VERSION (2021.01.04): 3390

	EPC concepts: 647

	APC concepts: 40	

	MoA concepts: 654

	PE concepts:  1868

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 25

	HC concepts:  31



------------------------------------------------------------------------------------------



November 2020 MED-RT (version name 2020.11.02)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2020.07.22)

	RxNorm (2020.10.05.20AA)

	MeSH (2020_2020.07.01)

	SNOMED CT US Edition (2020.09.20AA)

	UMLS Metathesaurus (2020AA)



TOTAL CONCEPTS IN PREVIOUS VERSION (2020.10.05): 3390

TOTAL CONCEPTS IN CURRENT VERSION (2020.11.02): 3390

	EPC concepts: 647

	APC concepts: 40	

	MoA concepts: 654

	PE concepts:  1868

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 25

	HC concepts:  31



------------------------------------------------------------------------------------------

October 2020 MED-RT (version name 2020.10.05)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2020.07.22)

	RxNorm (2020.09.08.20AA)

	MeSH (2020_2020.07.01)

	SNOMED CT US Edition (2020.09.20AA)

	UMLS Metathesaurus (2020AA)



TOTAL CONCEPTS IN PREVIOUS VERSION (2020.09.08): 3390

TOTAL CONCEPTS IN CURRENT VERSION (2020.10.05): 3390

	EPC concepts: 647

	APC concepts: 40	

	MoA concepts: 654

	PE concepts:  1868

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 25

	HC concepts:  31



------------------------------------------------------------------------------------------



August/September 2020 MED-RT (version name 2020.09.08)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2020.07.22)

	RxNorm (2020.08.03.20AA)

	MeSH (2020_2020.07.01)

	SNOMED CT US Edition (2020.03.19AB)

	UMLS Metathesaurus (2020AA)



TOTAL CONCEPTS IN PREVIOUS VERSION (2020.07.06): 3366

TOTAL CONCEPTS IN CURRENT VERSION (2020.09.08): 3390

	EPC concepts: 647

	APC concepts: 40	

	MoA concepts: 654

	PE concepts:  1868

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 25

	HC concepts:  31



This release includes eighteen newly restructured EPC hierarchies. The hierarchies are included as children of the 'Preprations by FDA Established Pharmacologic Class' concept. 



There were 24 Additional Pharmacologic Class concepts manually added for this release to the Established Pharmacologic Class hierarchy.



------------------------------------------------------------------------------------------

July 2020 MED-RT (version name 2020.07.06)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2020.04.28)

	RxNorm (2020.06.01.20AA)

	MeSH (2020_2020.01.01)

	SNOMED CT US Edition (2020.03.19AB)

	UMLS Metathesaurus (2020AA)



TOTAL CONCEPTS IN PREVIOUS VERSION (2020.06.01): 3355

TOTAL CONCEPTS IN CURRENT VERSION (2020.07.06): 3366

	EPC concepts: 647

	APC concepts: 16	

	MoA concepts: 654

	PE concepts:  1868

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 25

	HC concepts:  31



This release includes five newly restructured EPC hierarchy that can be found beneath the following concepts: "Anesthetic [APC]", "Anti-infective [APC]", "Enzyme [APC]", "Growth Factor [APC]", and "Receptor Interaction [APC]" 



There were 11 Additional Pharmacologic Class concepts manually added for this release to the Established Pharmacologic Class hierarchy.



------------------------------------------------------------------------------------------

June 2020 MED-RT (version name 2020.06.01)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2020.04.28)

	RxNorm (2020.05.04.20AA)

	MeSH (2020_2020.01.01)

	SNOMED CT US Edition (2020.03.19AB)

	UMLS Metathesaurus (2020AA)



TOTAL CONCEPTS IN PREVIOUS VERSION (2020.05.04): 3355

TOTAL CONCEPTS IN CURRENT VERSION (2020.06.01): 3355

	EPC concepts: 647

	APC concepts: 5	

	MoA concepts: 654

	PE concepts:  1868

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 25

	HC concepts:  31



------------------------------------------------------------------------------------------

May 2020 MED-RT (version name 2020.05.04)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2020.03.03)

	RxNorm (2020.04.06.19AB)

	MeSH (2020_2020.01.01)

	SNOMED CT US Edition (2020.03.19AB)

	UMLS Metathesaurus (2019AB)



TOTAL CONCEPTS IN PREVIOUS VERSION (2020.04.06): 3349

TOTAL CONCEPTS IN CURRENT VERSION (2020.05.04): 3355

	EPC concepts: 647

	APC concepts: 5	

	MoA concepts: 654

	PE concepts:  1868

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 25

	HC concepts:  31



This release includes two notable changes:

1.) Established Pharmacologic Class concepts that are not linked to an actively marketed drug in the FDA Structured Product Labeling have been placed beneath a new concept "Inactive Preparations by FDA Established Pharmacologic Class". 

2.) Established Pharmacologic Class concepts are in the process of being restructured to create a more comprehensive hierarchy of the classes. A new CTY of APC (Additional Pharmacologic Class) has been created to support the addition of grouper concepts for this effort. This release includes five newly restructured EPC hierarchies that can be found beneath the following concepts: "Antibody or Antibody Fragment [APC]", "Diuretic [APC]", "Hormone [APC]", "Imaging Agent [APC]", and "Vitamin or Mineral [APC]".    



There were 6 new concepts manually added for this release including 1 Hierarchical Concept and 5 Additional Pharmacologic Class concepts added to the Established Pharmacologic Class hierarchy.

------------------------------------------------------------------------------------------

April 2020 MED-RT (version name 2020.04.06)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2020.03.03)

	RxNorm (2020.03.02.19AB)

	MeSH (2020_2020.01.01)

	SNOMED CT US Edition (2020.03.19AB)

	UMLS Metathesaurus (2019AB)



TOTAL CONCEPTS IN PREVIOUS VERSION (2020.03.02): 3345

TOTAL CONCEPTS IN CURRENT VERSION (2020.04.06): 3349

	EPC concepts: 647	

	MoA concepts: 654

	PE concepts:  1868

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 25

	HC concepts:  30



There were 4 new concepts manually added for this release including 1 added to Established Pharmacologic Classes and 3 added to the Mechanism of Action hierarchy.

------------------------------------------------------------------------------------------

March 2020 MED-RT (version name 2020.03.02)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2019.11.13)

	RxNorm (2020.02.03.19AB)

	MeSH (2020_2020.01.01)

	SNOMED CT US Edition (2019.09.19AA)

	UMLS Metathesaurus (2019AB)



TOTAL CONCEPTS IN PREVIOUS VERSION (2020.02.03): 3345

TOTAL CONCEPTS IN CURRENT VERSION (2020.03.02): 3345

	EPC concepts: 646	

	MoA concepts: 651

	PE concepts:  1868

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 25

	HC concepts:  30



------------------------------------------------------------------------------------------

February 2020 MED-RT (version name 2020.02.03)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2019.11.13)

	RxNorm (2020.01.06.19AB)

	MeSH (2020_2020.01.01)

	SNOMED CT US Edition (2019.09.19AA)

	UMLS Metathesaurus (2019AB)



TOTAL CONCEPTS IN PREVIOUS VERSION (2020.01.06): 3341

TOTAL CONCEPTS IN CURRENT VERSION (2020.02.03): 3345

	EPC concepts: 646	

	MoA concepts: 651

	PE concepts:  1868

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 25

	HC concepts:  30



There were 4 new concepts manually added for this release including 2 added to Established Pharmacologic Classes and 2 added to the Mechanism of Action hierarchy.

------------------------------------------------------------------------------------------



December/January 2020 MED-RT (version name 2020.01.06)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2019.11.13)

	RxNorm (2019.12.02.19AB)

	MeSH (2019_2019.07.01)

	SNOMED CT US Edition (2019.09.19AA)

	UMLS Metathesaurus (2019AB)



TOTAL CONCEPTS IN PREVIOUS VERSION (2019.11.04): 3339

TOTAL CONCEPTS IN CURRENT VERSION (2020.01.06): 3341

	EPC concepts: 644	

	MoA concepts: 649

	PE concepts:  1868

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 25

	HC concepts:  30



There were 2 new concepts manually added to Established Pharmacologic Classes hierarchy for this release.

------------------------------------------------------------------------------------------

November 2019 MED-RT (version name 2019.11.04)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2019.07.15)

	RxNorm (2019.10.07.19AA)

	MeSH (2019_2019.07.01)

	SNOMED CT US Edition (2019.09.19AA)

	UMLS Metathesaurus (2019AA)



TOTAL CONCEPTS IN PREVIOUS VERSION (2019.10.07): 3339

TOTAL CONCEPTS IN CURRENT VERSION (2019.11.04): 3339

	EPC concepts: 642	

	MoA concepts: 649

	PE concepts:  1868

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 25

	HC concepts:  30



------------------------------------------------------------------------------------------

October 2019 MED-RT (version name 2019.10.07)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2019.07.15)

	RxNorm (2019.09.03.19AA)

	MeSH (2019_2019.07.01)

	SNOMED CT US Edition (2019.09.19AA)

	UMLS Metathesaurus (2019AA)



TOTAL CONCEPTS IN PREVIOUS VERSION (2019.09.03): 3332

TOTAL CONCEPTS IN CURRENT VERSION (2019.10.07): 3339

	EPC concepts: 642	

	MoA concepts: 649

	PE concepts:  1868

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 25

	HC concepts:  30



There were 7 new concepts manually added for this release including 3 added to Established Pharmacologic Classes and 4 added to the Mechanism of Action hierarchy.

	

------------------------------------------------------------------------------------------

August/September 2019 MED-RT (version name 2019.09.03)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2019.07.15)

	RxNorm (2019.08.05.19AA)

	MeSH (2019_2019.07.01)

	SNOMED CT US Edition (2019.03.18AB)

	UMLS Metathesaurus (2019AA)



TOTAL CONCEPTS IN PREVIOUS VERSION (2019.07.01): 3332

TOTAL CONCEPTS IN CURRENT VERSION (2019.09.03): 3332

	EPC concepts: 639	

	MoA concepts: 645

	PE concepts:  1868

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 25

	HC concepts:  30

	

------------------------------------------------------------------------------------------

July 2019 MED-RT (version name 2019.07.01)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2019.04.22)

	RxNorm (2019.06.03.19AA)

	MeSH (2019_2019.01.01)

	SNOMED CT US Edition (2019.03.18AB)

	UMLS Metathesaurus (2019AA)



TOTAL CONCEPTS IN PREVIOUS VERSION (2019.06.03): 3332

TOTAL CONCEPTS IN CURRENT VERSION (2019.07.01): 3332

	EPC concepts: 639	

	MoA concepts: 645

	PE concepts:  1868

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 25

	HC concepts:  30

	

------------------------------------------------------------------------------------------

June 2019 MED-RT (version name 2019.06.03)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2019.04.22)

	RxNorm (2019.05.06.19AA)

	MeSH (2019_2019.01.01)

	SNOMED CT US Edition (2019.03.18AB)

	UMLS Metathesaurus (2019AA)



TOTAL CONCEPTS IN PREVIOUS VERSION (2019.05.06): 3332

TOTAL CONCEPTS IN CURRENT VERSION (2019.06.03): 3332

	EPC concepts: 639	

	MoA concepts: 645

	PE concepts:  1868

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 25

	HC concepts:  30

	

------------------------------------------------------------------------------------------

May 2019 MED-RT (version name 2019.05.06)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2019.03.12)

	RxNorm (2019.04.01.18AB)

	MeSH (2019_2019.01.01)

	SNOMED CT US Edition (2019.03.18AB)

	UMLS Metathesaurus (2018AB)



TOTAL CONCEPTS IN PREVIOUS VERSION (2019.04.01): 3332

TOTAL CONCEPTS IN CURRENT VERSION (2019.05.06): 3332

	EPC concepts: 639	

	MoA concepts: 645

	PE concepts:  1868

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 25

	HC concepts:  30

	

------------------------------------------------------------------------------------------

April 2019 MED-RT (version name 2019.04.01)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2019.03.12)

	RxNorm (2019.03.04.18AB)

	MeSH (2019_2019.01.01)

	SNOMED CT US Edition (2019.03.18AB)

	UMLS Metathesaurus (2018AB)



TOTAL CONCEPTS IN PREVIOUS VERSION (2019.03.04): 3328

TOTAL CONCEPTS IN CURRENT VERSION (2019.04.01): 3332

	EPC concepts: 639	

	MoA concepts: 645

	PE concepts:  1868

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 25

	HC concepts:  30



There were 4 new concepts manually added for this release including 2 added to Established Pharmacologic Classes and 2 added to the Mechanism of Action hierarchy.

	

------------------------------------------------------------------------------------------



March 2019 MED-RT (version name 2019.03.04)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2019.02.04)

	RxNorm (2019.02.04.18AB)

	MeSH (2019_2019.01.01)

	SNOMED CT US Edition (2018.09.18AA)

	UMLS Metathesaurus (2018AB)



TOTAL CONCEPTS IN PREVIOUS VERSION (2019.02.04): 3328

TOTAL CONCEPTS IN CURRENT VERSION (2019.03.04): 3328

	EPC concepts: 637	

	MoA concepts: 643

	PE concepts:  1868

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 25

	HC concepts:  30

	

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February 2019 MED-RT (version name 2019.02.04)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2018.11.30)

	RxNorm (2019.01.07.18AB)

	MeSH (2019_2019.01.01)

	SNOMED CT US Edition (2018.09.18AA)

	UMLS Metathesaurus (2018AB)



TOTAL CONCEPTS IN PREVIOUS VERSION (2019.01.07): 3322

TOTAL CONCEPTS IN CURRENT VERSION (2019.02.04): 3328

	EPC concepts: 637	

	MoA concepts: 643

	PE concepts:  1868

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 25

	HC concepts:  30



There were 6 new concepts manually added for this release including 3 added to Established Pharmacologic Classes, 2 added to the Mechanism of Action hierarchy, and 1 added to the Terminology Extensions for Classification hierarchy.

	

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December/January 2019 MED-RT (version name 2019.01.07)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2018.11.30)

	RxNorm (2018.12.03.18AB)

	MeSH (2018_2018.07.01)

	SNOMED CT US Edition (2018.09.18AA)

	UMLS Metathesaurus (2018AB)



TOTAL CONCEPTS IN PREVIOUS VERSION (2018.11.05): 3322

TOTAL CONCEPTS IN CURRENT VERSION (2019.01.07): 3322

	EPC concepts: 634	

	MoA concepts: 641

	PE concepts:  1868

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 24

	HC concepts:  30

	

------------------------------------------------------------------------------------------



November 2018 MED-RT (version name 2018.11.05)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2018.06.05)

	RxNorm (2018.10.01.18AA)

	MeSH (2018_2018.07.01)

	SNOMED CT US Edition (2018.09.18AA)

	UMLS Metathesaurus (2018AA)



TOTAL CONCEPTS IN PREVIOUS VERSION (2018.10.01): 3322

TOTAL CONCEPTS IN CURRENT VERSION (2018.11.05): 3322

	EPC concepts: 634	

	MoA concepts: 641

	PE concepts:  1868

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 24

	HC concepts:  30

	

------------------------------------------------------------------------------------------

October 2018 MED-RT (version name 2018.10.01)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2018.06.05)

	RxNorm (2018.09.04.18AA)

	MeSH (2018_2018.07.01)

	SNOMED CT US Edition (2018.09.18AA)

	UMLS Metathesaurus (2018AA)



TOTAL CONCEPTS IN PREVIOUS VERSION (2018.09.04): 3286

TOTAL CONCEPTS IN CURRENT VERSION (2018.10.01): 3322

	EPC concepts: 634	

	MoA concepts: 641

	PE concepts:  1868

	PK concepts:  59

	TC concepts:  66

	EXT concepts: 24

	HC concepts:  30



There were 36 new concepts manually added for this release to the Therapeutic Categories hierarchy. This release also includes new relationships added by MED-RT SMEs for the following relationship types:

	CI_ChemClass

	CI_MoA

	CI_PE

	CI_with

	has_MoA

	has_PE

	has_TC

	may_prevent

	may_treat

	

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August/September 2018 MED-RT (version name 2018.09.04)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2018.06.05)

	RxNorm (2018.08.06.18AA)

	MeSH (2018_2018.07.01)

	SNOMED CT US Edition (2018.03.17AB)

	UMLS Metathesaurus (2018AA)



TOTAL CONCEPTS IN PREVIOUS VERSION (2018.07.02): 3286

TOTAL CONCEPTS IN CURRENT VERSION (2018.09.04): 3286

	EPC concepts: 634	

	MoA concepts: 641

	PE concepts:  1868

	PK concepts:  59

	TC concepts:  30

	EXT concepts: 24

	HC concepts:  30





------------------------------------------------------------------------------------------



July 2018 MED-RT (version name 2018.07.02)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	FDA SPL (2018.06.05)

	RxNorm (2018.06.04.18AA)

	MeSH (2018_2018.01.01)

	SNOMED CT US Edition (2018.03.17AB)

	UMLS Metathesaurus (2017AB)



TOTAL CONCEPTS IN PREVIOUS VERSION (2018.06.04): 3282

TOTAL CONCEPTS IN CURRENT VERSION (2018.07.02): 3286

	EPC concepts: 634	

	MoA concepts: 641

	PE concepts:  1868

	PK concepts:  59

	TC concepts:  30

	EXT concepts: 24

	HC concepts:  30



There were 4 new concepts manually added for this release including 2 added to Established Pharmacologic Classes and 2 added to the Mechanism of Action hierarchy. 



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June 2018 MED-RT (version name 2018.06.04)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources:

	RxNorm (2018.05.07.18AA)

	MeSH (2018_2018.01.01)

	SNOMED CT US Edition (2018.03.17AB)

	UMLS Metathesaurus (2017AB)



TOTAL CONCEPTS IN PREVIOUS VERSION (2018.05.07): 3282

TOTAL CONCEPTS IN CURRENT VERSION (2018.06.04): 3282

	EPC concepts: 632	

	MoA concepts: 639

	PE concepts:  1868

	PK concepts:  59

	TC concepts:  30

	EXT concepts: 24

	HC concepts:  30



A new authority with a value of 'NLMUMLS' was added to this release to support relationships from RxNorm ingredients to MeSH structural classes as defined by the UMLS Metathesaurus. 



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May 2018 MED-RT (version name 2018.05.07)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources and updated using the FDA SPL file dated 3/16/18:

	RxNorm (2018.04.02.17AB)

	MeSH (2018_2018.01.01)

	SNOMED CT US Edition (2018.03.17AB)



TOTAL CONCEPTS IN PREVIOUS VERSION (2018.04.02): 3277

TOTAL CONCEPTS IN CURRENT VERSION (2018.05.07): 3282

	EPC concepts: 632	

	MoA concepts: 639

	PE concepts:  1868

	PK concepts:  59

	TC concepts:  30

	EXT concepts: 24

	HC concepts:  30



There were 5 new concepts manually added for this release including 3 added to Established Pharmacologic Classes and 2 added to the Mechanism of Action hierarchy.



The following relationship names have been changed in this release:

has_Ingredient -> Synonym Of                                

has_Chemical_Structure -> has_SC

has_SNOMED_parent -> Child Of   

has_SNOMED_child -> Parent Of                           

has_SNOMED_synonym -> Synonym Of               



Please see the full MED-RT documentation for additional relationship information.



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April 2018 MED-RT (version name 2018.04.02)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them.  



Content in this version of MED-RT represents revisions based on data in the following sources and updated using the FDA SPL file dated 3/14/18:

	RxNorm (2018.03.05.17AB)

	MeSH (2018_2018.01.01)

	SNOMED CT US Edition (2017.09.17AA)



TOTAL CONCEPTS IN PREVIOUS VERSION (2018.03.05): 3267

TOTAL CONCEPTS IN CURRENT VERSION (2018.04.02): 3277

	EPC concepts: 629	

	MoA concepts: 637

	PE concepts:  1868

	PK concepts:  59

	TC concepts:  30

	EXT concepts: 24

	HC concepts:  30



There were 10 new concepts manually added for this release including 2 added to Established Pharmacologic Classes, 6 added to the Mechanism of Action hierarchy, and 2 added to the Physiological Effects hierarchy.



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March 2018 MED-RT (version name 2018.03.05)



The Medication Reference Terminology (MED-RT) is the evolutionary successor to the Veterans Health Administration National Drug File – Reference Terminology (VHA NDF-RT™). Both are formal ontological representations of medication terminology, pharmacologic classifications, and asserted authoritative relationships between them. Distribution of MED-RT is through the same channels on the same monthly schedule as its predecessor NDF-RT, in XML and other formats. 



Content in this version of MED-RT represents revisions based on data in the following sources and updated using the FDA SPL file dated 2/5/18:

	NDF-RT (2018.02.05.17AB)

	RxNorm (2018.02.05.17AB)

	MeSH (2017_2017.09.19)

	SNOMED CT US Edition (2017.09.17AA)



TOTAL CONCEPTS IN CURRENT VERSION (2018.03.05): 3267

	EPC concepts: 627	

	MoA concepts: 631

	PE concepts:  1866

	PK concepts:  59

	TC concepts:  30

	EXT concepts: 24

	HC concepts:  30



There were 5 new concepts manually added for this release including 2 added to Established Pharmacologic Classes and 3 added to the Mechanism of Action hierarchy.