D	C177536	GDC Property Terminology	C177574	Coal Dust Exposure	Environmental or occupational exposure to dust derived during the processing of coal.	coal_dust_exposure	coal dust exposure	
D	C177536	GDC Property Terminology	C177580	TCGA Analyte Type Identifier	A single uppercase letter assigned to a specific analyte type by the The Cancer Genome Atlas (TCGA).	analyte_type_id	analyte type id	
D	C177536	GDC Property Terminology	C177581	TCGA Sample Type Identifier	A two digit numerical identifier assigned to a specific sample type by the The Cancer Genome Atlas (TCGA).	sample_type_id	sample type id	
D	C177536	GDC Property Terminology	C181711	Average Number of Times per Day Subject Uses Tobacco	A question regarding the average number of times per day that a subject uses a tobacco product.	tobacco_use_per_day	tobacco use per day	
D	C177536	GDC Property Terminology	C185077	OCT Embedded Indicator	An indicator that specifies whether a specimen or sample was embedded in optimal cutting temperature (OCT) compound.	oct_embedded	oct embedded	
D	C177536	GDC Property Terminology	C53414	Composition	The way in which something is made, especially in terms of its different parts; its constituents.	composition		
C	C177536	GDC Property Terminology	C164057	Smoke Exposure	Environmental, occupational or consumer-based exposure to airborne gases and particulates produced when materials undergo combustion or thermal decomposition.	type_of_smoke_exposure	type of smoke exposure	
C	C177536	GDC Property Terminology	C16457	Comorbidity	The coexistence of two or more disease processes.	comorbidities		
C	C177536	GDC Property Terminology	C17103	Risk Factor	Any aspect of an individual's life, behavior, an environmental exposure, or an inborn or inherited characteristic that increases the likelihood of a disease, condition or injury.	risk_factors	risk factors	
C	C177536	GDC Property Terminology	C172272	Electronic File Content Type	The nature of the content stored in an electronic file.	data_type	data type	
C	C177536	GDC Property Terminology	C70713	Biospecimen Type	The type of a material sample taken from a biological entity for testing, diagnostic, propagation, treatment or research purposes. This includes particular types of cellular molecules, cells, tissues, organs, body fluids, embryos, and body excretory substances.	specimen_type	specimen type	
A	C177536	GDC Property Terminology	C104015	WEISS Criteria	Histopathologic criteria to evaluate adrenocortical tumors.  These criteria include nuclear grade III or IV, mitotic rate greater than five per fifty high power fields, presence of atypical mitotic figures, presence of less than or equal to twenty five percent of clear or vacuolated cells that resemble normal zona fasciculata, diffuse architecture, necrosis, venous invasion, sinusoid invasion, and invasion of tumor capsule.	weiss_assessment_findings	weiss assessment findings	
A	C177536	GDC Property Terminology	C106551	Number of Pregnancies	A measurement of the total number of pregnancy events experienced by the female subject.	pregnancy_count	pregnancy count	
A	C177536	GDC Property Terminology	C111028	Extrascleral Extension of Uveal Melanoma	Spread of uveal melanoma beyond the sclera.	extrascleral_extension	extrascleral extension	
A	C177536	GDC Property Terminology	C13355	Chromosome Arm	Under the microscope chromosomes appear as thin, thread-like structures. They all have a short arm and long arm separated by a primary constriction called the centromere. The short arm is designated as p and the long arm as q.	chromosome_arm	chromosome arm	
A	C177536	GDC Property Terminology	C15538	Protocol Treatment Arm	A specific treatment plan within a clinical trial that describes the activities a subject will be involved in as he or she progresses through the study.	treatment_arm	treatment arm	
A	C177536	GDC Property Terminology	C159643	Was Lymph Node Dissection Performed	A question asking if lymph node dissection was performed during the study.	lymph_nodes_removed	lymph nodes removed	
A	C177536	GDC Property Terminology	C160837	Is Extranodal Tumor Involvement Present	A question about whether extranodal tumor involvement is present.	extranodal_extension	extranodal extension	
A	C177536	GDC Property Terminology	C166235	Medication Course Number	The number assigned to a course of therapeutic agent administration, indicating where a particular course of treatment falls within a sequence of treatments.	course_number	course number	
A	C177536	GDC Property Terminology	C176278	Maximum Dose Amount	A determination of the maximum dose of a treatment taken by an individual.	treatment_dose_max	treatment dose max	
A	C177536	GDC Property Terminology	C182312	Image Anatomic Location	The anatomic location of the image.	imaging_anatomic_site	imaging anatomic site	
A	C177536	GDC Property Terminology	C188000	How Often Have Alcoholic Drink	A question about how often an individual has or had a drink containing alcohol.	alcohol_frequency	alcohol frequency	
A	C177536	GDC Property Terminology	C198090	Age at Last Exposure	Age of subject at the last known exposure to a hazardous factor or substance.	age_at_last_exposure	age at last exposure	
A	C177536	GDC Property Terminology	C198091	Cancer Detection Method	The observational modality that was utilized to detect the cancer.	cancer_detection_method	cancer detection method	
A	C177536	GDC Property Terminology	C198092	Chemical Exposure Type Indicator	An indicator specifying the chemical or chemical class to which a subject was exposed.	chemical_exposure_type	chemical exposure type	
A	C177536	GDC Property Terminology	C198093	Number of Days Between Index Date and First Event	The number of days between an index date and the date of the first reported event following treatment.	days_to_first_event	days to first event	
A	C177536	GDC Property Terminology	C198094	Number of Days Between Index Date and Risk Factor Diagnosis	The number of days between an index date and the date that an individual is diagnosed with a specific risk factor.	days_to_risk_factor	days to risk factor	
A	C177536	GDC Property Terminology	C198095	Disease Progression Evidence	The clinical or laboratory test result that was the basis for a progressive disease finding.	evidence_of_progression_type	evidence of progression type	
A	C177536	GDC Property Terminology	C198101	Extracapsular Extent Indicator	An indication of whether the extent of tumor invasion through an organ capsule is focal or extensive, or if it was not reported.	extracapsular_extension	extracapsular extension	
A	C177536	GDC Property Terminology	C198107	First Post-treatment Event	The first clincally-relevant event following treatment.	first_event	first event	
A	C177536	GDC Property Terminology	C198109	Number of Treated Lesions	The number of lesions subjected to treatment.	lesions_treated_number	lesions treated number	
A	C177536	GDC Property Terminology	C198127	Lymph Node Dissection Site	The anatomic site involved in a lymph node dissection procedure.	lymph_node_dissection_site	lymph node dissection site	
A	C177536	GDC Property Terminology	C198130	Minimal Submucosal Invasion	A morphological finding indicating the minimum depth of tumor invasion into the submucosal tissue.	minimum		
A	C177536	GDC Property Terminology	C198131	Variant Codon Position Number	The number indicating the position of a codon that is involved in a genetic variation.	mutation_codon	mutation codon	
A	C177536	GDC Property Terminology	C198132	Total Number of Radiotherapy Dose Fractions Received	The total number of fractionated radiation doses received.	number_of_fractions	number of fractions	
A	C177536	GDC Property Terminology	C198139	Peritoneal Wash Cytology Results Indicator	An indication as to whether cells were present, absent or not reported in a peritoneal wash specimen.	peritoneal_washing_results	peritoneal washing results	
A	C177536	GDC Property Terminology	C198143	Prescribed Dose	The amount of agent or medication formally prescribed to an individual.	prescribed_dose	prescribed dose	
A	C177536	GDC Property Terminology	C198194	Residual Tumor Size Measurement	A procedure that measures the size of a residual tumor mass.	residual_tumor_measurement	residual tumor measurement	
A	C177536	GDC Property Terminology	C198195	Risk Factor Diagnostic Method	The modality that was used to determine the presence and identity of a risk factor.	risk_factor_method_of_diagnosis	risk factor method of diagnosis	
A	C177536	GDC Property Terminology	C198197	Number of Disease-Involved Anatomic Sites	The number of anatomic sites found to be involved in the disease.	sites_of_involvement_count	sites of involvement count	
A	C177536	GDC Property Terminology	C198198	Therapeutic Agent Level Achieved Indicator	An indication that the intended level of therapeutic agent was achieved in an individual.	therapeutic_level_achieved	therapeutic level achieved	
A	C177536	GDC Property Terminology	C198199	Test Value Percentile Range	The minimum and maximum percentile that bound the range in which an individual's test result values fell.	test_value_range	test value range	
A	C177536	GDC Property Terminology	C198200	Therapeutic Agent Targeted Administration Concentration	The intended concentration for administration of the therapeutic agent.	therapeutic_target_level	therapeutic target level	
A	C177536	GDC Property Terminology	C198201	Timepoint Event Category	The classification or description of an event that is observed or recorded during a clinical encounter where a treatment is administered, a sample is collected for laboratory or molecular analysis or follow-up information is gathered.	timepoint_category	timepoint category	
A	C177536	GDC Property Terminology	C198202	Treatment Duration in Days	The number of days during which a treatment was administered to an individual.	treatment_duration	treatment duration	
A	C177536	GDC Property Terminology	C198203	Number of Elapsed Days Between Treatment and Outcome	The elapsed number of days between treatment completion and the occurrence of specific result or effect.	treatment_outcome_duration	treatment outcome duration	
A	C177536	GDC Property Terminology	C198204	Tumor Grade Evaluation Tier Number	The number of clinical observation tiers used in the evaluation of the tumor grade.	tumor_grade_category	tumor grade category	
A	C177536	GDC Property Terminology	C198205	Prostate Level Disease Origin Indicator	An indication that the apex, middle or base of the prostate was identified as the origin of the disease.	tumor_level_prostate	tumor level prostate	
A	C177536	GDC Property Terminology	C198206	UICC Staging System Manual	The criteria developed by the Union for International Cancer Control (UICC) for the classification and staging of neoplastic diseases.	uicc_staging_system_edition	uicc staging system edition	
A	C177536	GDC Property Terminology	C198207	Substance Use Per Day	A question regarding the average number of times per day that an individual uses a substance of interest.	use_per_day	use per day	
A	C177536	GDC Property Terminology	C198208	Year of Last Follow Up	The four digit year associated with the last clinical follow up.	year_of_follow_up	year of follow up	
A	C177536	GDC Property Terminology	C198458	Lymph Node Dissection Type	The type of lymphadenectomy performed.	lymph_node_dissection_method	lymph node dissection method	
A	C177536	GDC Property Terminology	C199145	Clinical Finding Detected by Imaging	An indication that a finding was detected using imaging techniques.	imaging_findings	imaging findings	
A	C177536	GDC Property Terminology	C199361	Tumor Thickness	A measurement of the distance between two opposite surfaces of a tumor.	tumor_thickness	tumor thickness	
A	C177536	GDC Property Terminology	C25193	Occupation	The principal activity that a person does to earn money.	occupation_type	occupation type	
A	C177536	GDC Property Terminology	C28084	Gleason Score for Prostate Cancer	The score derived from universally embraced prostate cancer grading system developed by Dr. Donald F. Gleason in 1977. The system provides a reproducible description of the glandular architecture of prostate tissue to which a pathologist assigns a score depending primarily on the microscopic patterns of cancerous glands and cell morphology. The system correlates well with behavior at the extremes: Gleason 1+1 tumors are the most well differentiated, slowly growing and rarely spread; Gleason 4+5 tumors are the most poorly differentiated, often widely metastatic at the time of diagnosis. In the commoner intermediate grade tumors, however, behavior is extremely variable.	gleason_score	gleason score	
A	C177536	GDC Property Terminology	C2873	Aneuploidy	A chromosomal abnormality in which there is an addition or loss of chromosomes within a set (e.g., 23 + 22 or 23 + 24).	aneuploidy		
A	C177536	GDC Property Terminology	C3420	Chromosomal Translocation	A genetic exchange where a piece of one chromosome is transferred to another chromosome.	chromosomal_translocation	chromosomal translocation	
A	C177536	GDC Property Terminology	C69310	Standardized Uptake Value	An effectively dimensionless measure of regional tracer uptake calculated as the activity concentration within a 2D region of interest (ROI) or 3D volume of interest (VOI) measured on a PET image (nCi1mL) / [injected dose (nCi) / body weight (g)].	imaging_suv	imaging suv	
A	C177536	GDC Property Terminology	C91220	French-American-British Classification	A classification system for acute myeloid leukemias, acute lymphoblastic leukemias, and myelodysplastic syndromes.  It is based on the morphologic and cytochemical evaluation of bone marrow and peripheral blood smears.	fab_morphology_code	fab morphology code	
A	C177536	GDC Property Terminology	C95012	Standardized Uptake Value Maximum	The maximum standardized uptake value among the pixels (voxels) within a region of interest.	imaging_suv_max	imaging suv max	
D	C177537	GDC Value Terminology	C129499	Embryonal Tumor with Multilayered Rosettes without C19MC Alteration	An embryonal tumor with multilayered rosettes characterized by the absence of C19MC amplification. Approximately half of embryonal tumors with multilayered rosettes that lack a C19MC alteration carry DICER1 mutations.	9478/3 | morphology || Embryonal tumor with multilayered rosettes, NOS | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
D	C177537	GDC Value Terminology	C132248	AJCC v8 Stage	A cancer stage defined according to the AJCC 8th edition criteria.	8th | ajcc_staging_system_edition	C177561	ajcc_staging_system_edition
D	C177537	GDC Value Terminology	C138107	Autologous Genetically-modified MAGE-A4 C1032 T Cells	Autologous human T-lymphocytes transduced with a retroviral vector encoding a T-cell receptor (TCR) specific for the human melanoma antigen A4 (MAGE-A4), with potential immunostimulatory and antineoplastic activities. Upon leukapheresis, isolation, transduction, expansion ex vivo, and reintroduction into the patient, the autologous genetically-modified MAGE-A4 C1032 T-cells bind to tumor cells expressing MAGE-A4. This may result in both inhibition of growth and increased cell death of MAGE-A4-expressing tumor cells. The tumor-associated antigen MAGE-A4, a member of the MAGE-A family of cancer testis antigens, is overexpressed by a variety of cancer cell types.	Autologous Genetically-modified MAGE-A4 C1032 T Cells | therapeutic_agents	C1909	therapeutic_agents
D	C177537	GDC Value Terminology	C156440	Metastatic Tumor Sample	A biospecimen derived from a metastatic tumor.	06 | sample_type_id || 07 | sample_type_id || Additional Metastatic | sample_type || Metastatic | sample_type	C177581 || C70713	sample_type_id || sample_type
D	C177537	GDC Value Terminology	C156441	Sample Derived from New Primary	A biospecimen derived from a new primary tumor.	05 | sample_type_id || Additional - New Primary | sample_type	C177581 || C70713	sample_type_id || sample_type
D	C177537	GDC Value Terminology	C156443	Cell Line-Derived Xenograft	A biospecimen derived from the culturing of a derived cell line in a non-human organism.	61 | sample_type_id || Cell Line Derived Xenograft Tissue | sample_type	C177581 || C70713	sample_type_id || sample_type
D	C177537	GDC Value Terminology	C156444	Post Neoadjuvant Therapy Sample	A biospecimen derived from a subject after treatment with a neoadjuvant therapeutic.	Post neo-adjuvant therapy | sample_type	C70713	sample_type
D	C177537	GDC Value Terminology	C164015	Blood Cancer-Derived Bone Marrow Specimen	A bone marrow specimen collected from a subject that has been diagnosed with a liquid tumor.	09 | sample_type_id || Blood Derived Cancer - Bone Marrow | sample_type || Primary Blood Derived Cancer - Bone Marrow | sample_type	C177581 || C70713	sample_type_id || sample_type
D	C177537	GDC Value Terminology	C164017	Blood Cancer-Derived Bone Marrow Specimen, Post-Treatment	A bone marrow specimen collected from a subject after receiving treatment for a liquid tumor.	04 | sample_type_id || Blood Derived Cancer - Bone Marrow, Post-treatment | sample_type || Recurrent Blood Derived Cancer - Bone Marrow | sample_type	C177581 || C70713	sample_type_id || sample_type
D	C177537	GDC Value Terminology	C164030	Blood Cancer-Derived Blood Specimen	A whole blood specimen collected from a subject that has been diagnosed with a liquid tumor.	03 | sample_type_id || Blood Derived Cancer - Peripheral Blood | sample_type || Primary Blood Derived Cancer - Peripheral Blood | sample_type	C177581 || C70713	sample_type_id || sample_type
D	C177537	GDC Value Terminology	C164031	Blood Cancer-Derived Blood Specimen, Post-Treatment	A whole blood specimen collected from a subject after receiving treatment for a liquid tumor.	40 | sample_type_id || Blood Derived Cancer - Peripheral Blood, Post-treatment | sample_type || Recurrent Blood Derived Cancer - Peripheral Blood, Post Treatment | sample_type	C177581 || C70713	sample_type_id || sample_type
D	C177537	GDC Value Terminology	C164033	Tumor-Adjacent Normal Post Neoadjuvant Therapy Sample	A specimen derived from a tumor-adjacent normal tissue specimen that was collected from the subject after treatment with a neoadjuvant therapeutic.	Tumor Adjacent Normal - Post Neo-adjuvant Therapy | sample_type	C70713	sample_type
D	C177537	GDC Value Terminology	C165220	Low-Pass Whole Genome Sequencing	A form of whole genome sequencing where the sequencing read depth falls between 0.1 and 30 times.	Low Pass WGS | experimental_strategy	C43622	experimental_strategy
D	C177537	GDC Value Terminology	C172267	Formalin-Fixed Paraffin-Embedded Tissue Sample from Recurrent Disease	A formalin-fixed, paraffin-embedded sample derived from tissue isolated from a subject with recurrent disease.	FFPE Recurrent | sample_type	C70713	sample_type
D	C177537	GDC Value Terminology	C172268	Formalin-Fixed Paraffin-Embedded Tissue Scroll	A formalin-fixed, paraffin-embedded tissue sample that has been cut on a microtome so that it rolls up on itself.	FFPE Scroll | sample_type	C70713	sample_type
D	C177537	GDC Value Terminology	C172293	Original Tumor Cell Sample	A sample comprised of cells that were isolated from a tumor and have not been cultured or expanded.	08 | sample_type_id || Human Tumor Original Cells | sample_type	C177581 || C70713	sample_type_id || sample_type
D	C177537	GDC Value Terminology	C172295	Next Generation Cancer Model	An approach to cancer modeling that utilizes clinical data as well as the genomic and transcriptomic profiles of the parent tumor, metastases, if present, and case-matched normal tissues from individual patients.	Next Generation Cancer Model | sample_type	C70713	sample_type
D	C177537	GDC Value Terminology	C172296	Biospecimen on a Slide	The deposition of a biospecimen onto a slide prior to analysis.	Slides | sample_type	C70713	sample_type
D	C177537	GDC Value Terminology	C18211	Protein Overexpression	Synthesis of excess polypeptide within the cell. Overexpression is often due to the amplification or deregulation of the gene which encodes the gene product.	Overexpressed | relationship_type	C36292	test_result
D	C177537	GDC Value Terminology	C184757	Expanded Next Generation Cancer Model	A next generation cancer model that has been expanded using tissue culture or other methods.	Expanded Next Generation Cancer Model | sample_type	C70713	sample_type
D	C177537	GDC Value Terminology	C184781	Next Generation Cancer Model Expanded Under Non-Conforming Conditions	A next generation cancer model that has been expanded using unconventional culturing methods.	Next Generation Cancer Model Expanded Under Non-Conforming Conditions | sample_type	C70713	sample_type
D	C177537	GDC Value Terminology	C3176	Philadelphia-Negative Myelogenous Leukemia	Myelogenous leukemia that is negative for Philadelphia chromosome.	9876/3 | morphology || Atypical chronic myeloid leukemia, BCR/ABL negative | primary_diagnosis || Atypical chronic myeloid leukemia, Philadelphia chromosome (Ph1) negative | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
D	C177537	GDC Value Terminology	C36118	In Situ Lesion		In Situ Neoplasms | sample_type	C70713	sample_type
D	C177537	GDC Value Terminology	C7167	Myelodysplastic Syndrome with Excess Blasts-1	A myelodysplastic syndrome defined by 5-9% blasts in the bone marrow, and <5% blasts in the blood.  Approximately 25% of cases progress to an acute leukemia. (WHO)	RAEB I | primary_diagnosis	C177621	primary_diagnosis
D	C177537	GDC Value Terminology	C829	Tobacco Smoke	Smoke from burning tobacco (cigarettes, cigars, or pipes) and exhaled by a smoker.  Tobacco smoke contains nicotine, a stimulant, and other biologically active chemicals having carcinogenic properties.	Tobacco smoke, NOS | type_of_smoke_exposure	C164057	type_of_smoke_exposure
D	C177537	GDC Value Terminology	C90529	AJCC v6 Stage	A cancer stage defined according to the AJCC 6th edition criteria.	6th | ajcc_staging_system_edition	C177561	ajcc_staging_system_edition
D	C177537	GDC Value Terminology	C90530	AJCC v7 Stage	A cancer stage defined according to the AJCC 7th edition criteria.	7th | ajcc_staging_system_edition	C177561	ajcc_staging_system_edition
C	C177537	GDC Value Terminology	C103817	Hereditary Prostate Carcinoma	Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma.	Hereditary Prostate Cancer | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C106428	Catequentinib Hydrochloride	The hydrochloride salt form of catequentinib, a receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic and anti-angiogenic activities. Upon administration, catequentinib targets multiple RTKs, including vascular endothelial growth factor receptor type 2 (VEGFR2) and type 3 (VEGFR3). This agent may both inhibit angiogenesis and halt tumor cell growth.	Anlotinib Hydrochloride | therapeutic_agents	C1909	therapeutic_agents
C	C177537	GDC Value Terminology	C113330	Plixorafenib	An orally bioavailable inhibitor and specific dimer breaker of the serine/threonine-protein kinase B-raf (BRAF) protein, with potential antineoplastic activity. Upon oral administration, plixorafenib selectively binds to and inhibits the activity of dimeric BRAF mutants, including BRAF fusions and splice variants, and BRAFV600 monomers, while sparing RAF function in normal cells. This inhibits the proliferation of tumor cells which express these mutated forms of BRAF. BRAF, a member of the raf family of serine/threonine protein kinases, plays a role in the regulation of mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK) signaling pathways, which may be constitutively activated due to BRAF gene mutations. Mutated forms and fusions of BRAF are associated with a number of neoplastic diseases.	BRAF Inhibitor PLX8394 | therapeutic_agents	C1909	therapeutic_agents
C	C177537	GDC Value Terminology	C113681	Skin Tattoo	A permanent mark created by the insertion of pigment below the skin.	Tattoo | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C114476	Allergic Reaction	An immune response that occurs following re-exposure to an innocuous antigen, and that requires the presence of existing antibodies against that antigen. This response involves the binding of IgE to mast cells, and may worsen with repeated exposures.	Allergies | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C114666	Hemorrhagic Cystitis	Inflammation of the bladder resulting in bloody urine.	Hemorrhagic Cystitis | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C115248	Methicillin-Resistant Staphylococcus aureus Infection	A bacterial infection that is caused by Staphylococcus aureus that is not susceptible to methicillin.	Methicillin-Resistant Staphylococcus aureus (MRSA) | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C118385	Avascular Necrosis	Tissue death resulting from an interruption to the blood supply.	Avascular Necrosis | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C119734	Peripheral Neuropathy	A disorder affecting the peripheral nervous system. It manifests with pain, tingling, numbness, and muscle weakness. It may be the result of physical injury, toxic substances, viral diseases, diabetes, renal failure, cancer, and drugs.	Peripheral Neuropathy | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C120083	Hereditary Nonpolyposis Colorectal Cancer Syndrome	An inherited syndrome characterized by the development of several cancers, particularly colon and rectal cancers.  It includes Lynch syndrome which is associated with germline mutations in DNA mismatch-repair genes and familial colorectal cancer type X which is characterized by the absence of germline mutations in DNA mismatch-repair genes.	Hereditary Non-polyposis Colon Cancer | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C120211	Elacestrant	An orally available, selective estrogen receptor degrader (SERD), with antineoplastic activity. Upon oral administration, elacestrant acts as a SERD, which binds to the estrogen receptor (ER) and induces a conformational change that results in the proteosomal degradation of the receptor. This prevents ER-mediated signaling and inhibits proliferation of ER-expressing cancer cells.	Elacestrant | therapeutic_agents	C1909	therapeutic_agents
C	C177537	GDC Value Terminology	C120861	Adenosis	Any disease or disorder of a gland, characterized by abnormal development or enlargement of the gland.	Adenosis (Atypical Adenomatous Hyperplasia) | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C121628	Altered Mental Status	A change to an individual's judgment, orientation (to place, time, and self), intellectual functioning, or mood from their baseline.	Altered Mental Status | first_symptom_prior_to_diagnosis || Altered Mental Status | risk_factors	C157233 || C17103	first_symptom_prior_to_diagnosis || risk_factors
C	C177537	GDC Value Terminology	C12233	Submandibular Salivary Gland	One of a pair of major salivary glands located below the floor of the mouth.	Submandibular Gland | biospecimen_anatomic_site || Submandibular gland | progression_or_recurrence_anatomic_site || Submandibular gland | site_of_resection_or_biopsy || Submandibular gland | tissue_or_organ_of_origin	C156421 || C156422 || C171435 || C177570	site_of_resection_or_biopsy || tissue_or_organ_of_origin || biospecimen_anatomic_site || progression_or_recurrence_anatomic_site
C	C177537	GDC Value Terminology	C122403	Suvemcitug	A monoclonal antibody directed against the human vascular endothelial growth factor (VEGF), with potential antiangiogenic activity. Upon administration, suvemcitug specifically binds to and inhibits VEGF, thereby preventing its binding to VEGF receptors (VEGFRs). This prevents VEGF/VEGFR-mediated signaling and inhibits the proliferation of vascular endothelial cells and tumor cells. VEGF, overexpressed in a variety of cancer cells, is associated with increased invasiveness and decreased survival.	Sevacizumab | therapeutic_agents	C1909	therapeutic_agents
C	C177537	GDC Value Terminology	C122576	Staphylococcus aureus Infection	An infectious process in which the bacteria Staphylococcus aureus is present.	Staphylococcus aureus | comorbidities || Staphylococcus aureus | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C122822	Cholelithiasis	The presence of calculi in the gallbladder.	Cholelithiasis | comorbidities || Cholelithiasis | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C123036	Tubulointerstitial Disease	Disease affecting the renal tubules and interstitium of the kidney.	Tubulointerstitial Disease | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C123160	Lepidic Adenocarcinoma	A lung adenocarcinoma characterized by the presence of mildly and moderately differentiated adenocarcinoma cells across the alveolar walls with at least one focus of invasive carcinoma measuring more than 5 mm in greatest dimension.	Lepidic adenocarcinoma | primary_diagnosis || Lepidic predominant adenocarcinoma | primary_diagnosis	C177621	primary_diagnosis
C	C177537	GDC Value Terminology	C12320	Parametrium	The subserous connective tissue of the pelvic floor of the supracervical portion of the uterus. The parametrium extends laterally between the layers of the broad ligament.	Parametrium | progression_or_recurrence_anatomic_site || Parametrium | site_of_resection_or_biopsy || Parametrium | tissue_or_organ_of_origin || Parametrium | treatment_anatomic_site || Parametrium, Left | sites_of_involvement || Parametrium, Right | sites_of_involvement	C156421 || C156422 || C173263 || C177570 || C70729	site_of_resection_or_biopsy || tissue_or_organ_of_origin || sites_of_involvement || progression_or_recurrence_anatomic_site || treatment_anatomic_site
C	C177537	GDC Value Terminology	C12326	Undescended Testes	The failure of one or both testes of a male fetus to descend from the abdomen into the scrotum during the late part of pregnancy. If not surgically corrected in early childhood, males may be at increased risk for testicular cancer later in life.	Undescended Testis | risk_factors || Undescended testis | progression_or_recurrence_anatomic_site || Undescended testis | site_of_resection_or_biopsy || Undescended testis | tissue_or_organ_of_origin	C156421 || C156422 || C17103 || C177570	site_of_resection_or_biopsy || tissue_or_organ_of_origin || risk_factors || progression_or_recurrence_anatomic_site
C	C177537	GDC Value Terminology	C12351	Cerebral Hemisphere	The part of the brain that controls muscle functions and also controls speech, thought, emotions, reading, writing, and learning. The right hemisphere controls the muscles on the left side of the body, and the left hemisphere controls the muscles on the right side of the body.	Brain, Cerebrum | sites_of_involvement || Cerebrum | biospecimen_anatomic_site || Cerebrum | progression_or_recurrence_anatomic_site || Cerebrum | site_of_resection_or_biopsy || Cerebrum | tissue_or_organ_of_origin || Cerebrum | treatment_anatomic_site	C156421 || C156422 || C171435 || C173263 || C177570 || C70729	site_of_resection_or_biopsy || tissue_or_organ_of_origin || biospecimen_anatomic_site || sites_of_involvement || progression_or_recurrence_anatomic_site || treatment_anatomic_site
C	C177537	GDC Value Terminology	C12352	Frontal Lobe	The part of the brain located anterior to the parietal lobes at the front of each cerebral hemisphere.	Brain, Frontal lobe | sites_of_involvement || Frontal Lobe | biospecimen_anatomic_site || Frontal Lobe | treatment_anatomic_site || Frontal lobe | progression_or_recurrence_anatomic_site || Frontal lobe | site_of_resection_or_biopsy || Frontal lobe | supratentorial_localization || Frontal lobe | tissue_or_organ_of_origin	C156421 || C156422 || C171435 || C173263 || C177570 || C177571 || C70729	site_of_resection_or_biopsy || tissue_or_organ_of_origin || biospecimen_anatomic_site || sites_of_involvement || progression_or_recurrence_anatomic_site || supratentorial_localization || treatment_anatomic_site
C	C177537	GDC Value Terminology	C12353	Temporal Lobe	One of the cerebral lobes. It is located inferior to the frontal and parietal lobes and anterior to the occipital lobe.	Brain, Temporal lobe | sites_of_involvement || Temporal lobe | progression_or_recurrence_anatomic_site || Temporal lobe | site_of_resection_or_biopsy || Temporal lobe | supratentorial_localization || Temporal lobe | tissue_or_organ_of_origin	C156421 || C156422 || C173263 || C177570 || C177571	site_of_resection_or_biopsy || tissue_or_organ_of_origin || sites_of_involvement || progression_or_recurrence_anatomic_site || supratentorial_localization
C	C177537	GDC Value Terminology	C12354	Parietal Lobe	One of the lobes of the cerebral hemisphere located superiorly to the occipital lobe and posteriorly to the frontal lobe. Cognition and visuospatial processing are its main functions.	Brain, Parietal lobe | sites_of_involvement || Parietal lobe | progression_or_recurrence_anatomic_site || Parietal lobe | site_of_resection_or_biopsy || Parietal lobe | supratentorial_localization || Parietal lobe | tissue_or_organ_of_origin	C156421 || C156422 || C173263 || C177570 || C177571	site_of_resection_or_biopsy || tissue_or_organ_of_origin || sites_of_involvement || progression_or_recurrence_anatomic_site || supratentorial_localization
C	C177537	GDC Value Terminology	C12355	Occipital Lobe	One of the four regions of cortex in each cerebral hemisphere. It is located posterior to the temporal lobe and inferior to the parietal lobe.	Brain, Occipital lobe | sites_of_involvement || Occipital lobe | progression_or_recurrence_anatomic_site || Occipital lobe | site_of_resection_or_biopsy || Occipital lobe | supratentorial_localization || Occipital lobe | tissue_or_organ_of_origin	C156421 || C156422 || C173263 || C177570 || C177571	site_of_resection_or_biopsy || tissue_or_organ_of_origin || sites_of_involvement || progression_or_recurrence_anatomic_site || supratentorial_localization
C	C177537	GDC Value Terminology	C12356	Brain Ventricle	The four connected cavities (hollow spaces) centrally located within the brain that connect posteriorly with the central canal of the spinal cord.	Brain, Ventricle, NOS | sites_of_involvement || Ventricle, NOS | progression_or_recurrence_anatomic_site || Ventricle, NOS | site_of_resection_or_biopsy || Ventricle, NOS | tissue_or_organ_of_origin	C156421 || C156422 || C173263 || C177570	site_of_resection_or_biopsy || tissue_or_organ_of_origin || sites_of_involvement || progression_or_recurrence_anatomic_site
C	C177537	GDC Value Terminology	C12363	Pelvic Lymph Node	Any lymph node within the abdominal pelvic region.	Lymph Node(s) Pelvic | biospecimen_anatomic_site || Lymph Node(s) Pelvic | treatment_anatomic_site || Pelvic Lymph Node(s) | sites_of_involvement || Pelvic lymph nodes | progression_or_recurrence_anatomic_site || Pelvic lymph nodes | site_of_resection_or_biopsy || Pelvic lymph nodes | tissue_or_organ_of_origin || Pelvis, NOS | lymph_node_involved_site	C156421 || C156422 || C171435 || C173263 || C177570 || C33027 || C70729	site_of_resection_or_biopsy || tissue_or_organ_of_origin || biospecimen_anatomic_site || sites_of_involvement || progression_or_recurrence_anatomic_site || lymph_node_involved_site || treatment_anatomic_site
C	C177537	GDC Value Terminology	C12391	Stomach	The primary organ of food digestion. It is located under the diaphragm, between the liver and the spleen as well as between the esophagus and the small intestine.	Stomach | biospecimen_anatomic_site || Stomach | max_tumor_bulk_site || Stomach | metastasis_at_diagnosis_site || Stomach | primary_site || Stomach | sites_of_involvement || Stomach | treatment_anatomic_site || Stomach, NOS | progression_or_recurrence_anatomic_site || Stomach, NOS | site_of_resection_or_biopsy || Stomach, NOS | tissue_or_organ_of_origin	C156421 || C156422 || C158874 || C171435 || C173263 || C177570 || C177625 || C188396 || C70729	site_of_resection_or_biopsy || tissue_or_organ_of_origin || primary_site || biospecimen_anatomic_site || sites_of_involvement || progression_or_recurrence_anatomic_site || metastasis_at_diagnosis_site || max_tumor_bulk_site || treatment_anatomic_site
C	C177537	GDC Value Terminology	C124295	Pregnant	Observed to be or have been pregnant.	Pregnancy in Patient or Partner | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C12441	Brain Stem	Three sections, the midbrain, pons and medulla oblongata, that are located at the base of the brain. The brain stem regulates the central nervous system, and is vital as a conduit for motor and sensory innervations.	Brain Stem | biospecimen_anatomic_site || Brain Stem | treatment_anatomic_site || Brain stem | progression_or_recurrence_anatomic_site || Brain stem | site_of_resection_or_biopsy || Brain stem | tissue_or_organ_of_origin || Brain, Brain stem | sites_of_involvement	C156421 || C156422 || C171435 || C173263 || C177570 || C70729	site_of_resection_or_biopsy || tissue_or_organ_of_origin || biospecimen_anatomic_site || sites_of_involvement || progression_or_recurrence_anatomic_site || treatment_anatomic_site
C	C177537	GDC Value Terminology	C12445	Cerebellum	The portion of the brain located at the base of the skull that is responsible for balance, equilibrium and movement.	Brain, Cerebellum, NOS | sites_of_involvement || Cerebellum | biospecimen_anatomic_site || Cerebellum | treatment_anatomic_site || Cerebellum, NOS | progression_or_recurrence_anatomic_site || Cerebellum, NOS | site_of_resection_or_biopsy || Cerebellum, NOS | tissue_or_organ_of_origin	C156421 || C156422 || C171435 || C173263 || C177570 || C70729	site_of_resection_or_biopsy || tissue_or_organ_of_origin || biospecimen_anatomic_site || sites_of_involvement || progression_or_recurrence_anatomic_site || treatment_anatomic_site
C	C177537	GDC Value Terminology	C12508	Cell	The smallest units of living structure capable of independent existence, composed of a membrane-enclosed mass of protoplasm and containing a nucleus or nucleoid.	Cell | specimen_type	C70713	specimen_type
C	C177537	GDC Value Terminology	C12530	Granulocyte	A type of leukocyte with a multilobed nucleus and cytoplasmic granules. The unique morphology of the nucleus has led to their also being known as polymorphonuclear leukocytes (PMLs or PMNs). Granulocytes are subdivided according to the staining properties of their granules into eosinophils (red with acidic dye), basophils (blue with basic dye), and neutrophils (not amenable to staining with either acidic or basic dyes).	Granulocyte | biospecimen_type || Granulocytes | specimen_type	C70713 || C83315	specimen_type || biospecimen_type
C	C177537	GDC Value Terminology	C12535	Lymphocyte	White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each); those with characteristics of neither major class are called null cells.	Lymphocytes | specimen_type	C70713	specimen_type
C	C177537	GDC Value Terminology	C126449	Serous Tubal Intraepithelial Carcinoma	A non-invasive serous carcinoma arising from the fallopian tube.	Serous tubal intraepithelial carcinoma | primary_diagnosis || Serous tubal intraepithelial carcinoma (STIC) | risk_factors	C17103 || C177621	risk_factors || primary_diagnosis
C	C177537	GDC Value Terminology	C12664	Abdomen	The cavity located between the lungs and pelvis. It contains the lower esophagus, stomach, pancreas, intestines, liver, gallbladder and spleen.	Abdomen | biospecimen_anatomic_site || Abdomen | imaging_anatomic_site || Abdomen | metastasis_at_diagnosis_site || Abdomen | sites_of_involvement || Abdomen, NOS | progression_or_recurrence_anatomic_site || Abdomen, NOS | site_of_resection_or_biopsy || Abdomen, NOS | tissue_or_organ_of_origin || Abdomen, total | treatment_anatomic_site	C156421 || C156422 || C171435 || C173263 || C177570 || C177625 || C182312 || C70729	site_of_resection_or_biopsy || tissue_or_organ_of_origin || biospecimen_anatomic_site || sites_of_involvement || progression_or_recurrence_anatomic_site || metastasis_at_diagnosis_site || imaging_anatomic_site || treatment_anatomic_site
C	C177537	GDC Value Terminology	C126974	Sorted Cells	Cells separated and collected from a heterogeneous population based on physical, phenotypic, biochemical, and/or molecular properties, regardless of technique.	Sorted Cells | specimen_type	C70713	specimen_type
C	C177537	GDC Value Terminology	C12767	Pelvis	The bony, basin-shaped structure formed by the hipbones and the base of the backbone supporting the lower limbs in humans.	Pelvis | biospecimen_anatomic_site || Pelvis | imaging_anatomic_site || Pelvis | metastasis_at_diagnosis_site || Pelvis | sites_of_involvement || Pelvis | treatment_anatomic_site || Pelvis, NOS | progression_or_recurrence_anatomic_site || Pelvis, NOS | site_of_resection_or_biopsy || Pelvis, NOS | tissue_or_organ_of_origin	C156421 || C156422 || C171435 || C173263 || C177570 || C177625 || C182312 || C70729	site_of_resection_or_biopsy || tissue_or_organ_of_origin || biospecimen_anatomic_site || sites_of_involvement || progression_or_recurrence_anatomic_site || metastasis_at_diagnosis_site || imaging_anatomic_site || treatment_anatomic_site
C	C177537	GDC Value Terminology	C12799	Thorax	The division of the body lying between the neck and the abdomen.	Thorax | biospecimen_anatomic_site || Thorax | treatment_anatomic_site || Thorax, NOS | progression_or_recurrence_anatomic_site || Thorax, NOS | site_of_resection_or_biopsy || Thorax, NOS | sites_of_involvement || Thorax, NOS | tissue_or_organ_of_origin	C156421 || C156422 || C171435 || C173263 || C177570 || C70729	site_of_resection_or_biopsy || tissue_or_organ_of_origin || biospecimen_anatomic_site || sites_of_involvement || progression_or_recurrence_anatomic_site || treatment_anatomic_site
C	C177537	GDC Value Terminology	C128274	Circulating Cell-Free DNA	DNA found in blood plasma and other bodily fluids that is not associated with cells.	cfDNA | analyte_type	C156434	analyte_type
C	C177537	GDC Value Terminology	C128787	GenomePlex Whole Genome Amplification	A proprietary method for whole genome amplification (WGA) from very small samples using random fragmentation of genomic DNA and conversion of the resulting small fragments to a library of PCR-amplifiable molecules flanked by universal priming sites.	GenomePlex (Rubicon) Amplified DNA | analyte_type || Genomeplex | experimental_protocol_type	C156434 || C177560	analyte_type || experimental_protocol_type
C	C177537	GDC Value Terminology	C128788	REPLI-g Whole Genome Amplification	A proprietary method for whole genome amplification (WGA) from small samples using high-fidelity enzyme Phi 29 polymerase to amplify complex genomic DNA using Multiple Displacement Amplification (MDA) technology.	Repli-G | experimental_protocol_type || Repli-G (Qiagen) DNA | analyte_type	C156434 || C177560	analyte_type || experimental_protocol_type
C	C177537	GDC Value Terminology	C128829	HHV6 Infection	An infection that is caused by human herpesvirus-6.	Human Herpesvirus-6 (HHV-6) | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C12932	Xenograft	Cells, tissues, or organs from a donor that are transplanted into a recipient of another species.	Xenograft | tumor_descriptor	C166229	tumor_descriptor
C	C177537	GDC Value Terminology	C12933	Vertebra	Any of thirty-three ring-shaped structures that form the vertebral column which surrounds and protects the spinal cord. Each vertebra consists of a bony body with its superior and inferior articular surfaces covered by hyaline cartilage. The body includes the centrum anteriorly and vertebral arch posteriorly. The articular surfaces of the vertebrae are connected by a fibrocartilaginous intervertebral disc.	Vertebra | biospecimen_anatomic_site || Vertebra | treatment_anatomic_site || Vertebrae | sites_of_involvement	C171435 || C173263 || C70729	biospecimen_anatomic_site || sites_of_involvement || treatment_anatomic_site
C	C177537	GDC Value Terminology	C13049	Lymphoid Tissue	Tissue characterized by the presence of large numbers of lymphocytes in different stages of transformation. Connective tissue cells including fibroblasts and macrophages may be present. Lymphoid tissue is framed by a network of reticular fibers and may be diffuse, or densely aggregated.	Lymphoid | specimen_type	C70713	specimen_type
C	C177537	GDC Value Terminology	C13063	Neck	The region that connects the head to the rest of the body.	Neck | biospecimen_anatomic_site || Neck | max_tumor_bulk_site || Neck | metastasis_at_diagnosis_site || Neck | sites_of_involvement || Neck | treatment_anatomic_site || Neck, Left | lymph_node_dissection_site || Neck, NOS | lymph_node_dissection_site || Neck, Right | lymph_node_dissection_site	C171435 || C173263 || C177625 || C188396 || C198127 || C70729	biospecimen_anatomic_site || sites_of_involvement || metastasis_at_diagnosis_site || max_tumor_bulk_site || lymph_node_dissection_site || treatment_anatomic_site
C	C177537	GDC Value Terminology	C131579	Joint Replacement	A surgical procedure to replace part, or all structures, of a joint with an orthopedic prosthesis.	Joint Replacement | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C131907	Renvistobart	A human monoclonal antibody targeting the co-inhibitory molecule and immune checkpoint inhibitor T-cell immunoreceptor with immunoglobulin (Ig) and immunoreceptor tyrosine-based inhibitory motif (ITIM) domains (TIGIT), with potential immune checkpoint inhibitory activity. Upon administration, renvistobart binds to TIGIT expressed on various immune cells, particularly on tumor-infiltrating T-lymphocytes (TILs), thereby preventing the interaction of TIGIT with its ligands CD112 (nectin-2; poliovirus receptor related-2; PVRL2) and CD155 (poliovirus receptor; PVR; nectin-like protein 5; NECL-5). This enhances the interaction of CD112 and CD155 with the costimulatory receptor CD226 (DNAX Accessory molecule-1; DNAM-1), which is expressed on immune cells, such as natural killer (NK) cells and CD8+ T-cells, and leads to CD226 dimerization and CD226-mediated signaling. This activates the immune system to exert a T-cell-mediated immune response against cancer cells. TIGIT, a member of the Ig super family and an immune inhibitory receptor, plays a key role in the suppression of T-cell proliferation and activation; it is involved in tumor cell immune evasion, and the inhibition of antiviral immune responses.	Anti-TIGIT Monoclonal Antibody BMS-986207 | therapeutic_agents	C1909	therapeutic_agents
C	C177537	GDC Value Terminology	C13275	Saliva	The watery fluid in the mouth made by the salivary glands. Saliva moistens food to help digestion and it helps protect the mouth against infections.	Saliva | biospecimen_type	C83315	biospecimen_type
C	C177537	GDC Value Terminology	C13278	Sputum	Material containing mucus, cellular debris, microorganisms and sometimes blood or pus.  It is ejected through the mouth from the lungs, bronchi, and trachea.	Sputum | specimen_type	C70713	specimen_type
C	C177537	GDC Value Terminology	C13325	Serum	The clear portion of the blood that remains after the removal of the blood cells and the clotting proteins.	Serum | biospecimen_type || Serum | specimen_type	C70713 || C83315	specimen_type || biospecimen_type
C	C177537	GDC Value Terminology	C13356	Plasma	Plasma is the fluid (noncellular) portion of the circulating blood, as distinguished from the serum that is the fluid portion of the blood obtained by removal of the fibrin clot and blood cells after coagulation.	Plasma | biospecimen_type || Plasma | specimen_type	C70713 || C83315	specimen_type || biospecimen_type
C	C177537	GDC Value Terminology	C135727	Liquid Biopsy	Sampling and analysis of non-solid biological material (primarily blood), usually to determine if cancer cells or circulating-free cancer DNA is present.	Liquid Biopsy | method_of_sample_procurement	C70700	method_of_sample_procurement
C	C177537	GDC Value Terminology	C137676	Stage IIID	Locally advanced cancer that has spread to nearby organs but not to distant anatomic sites. The definition of stage IIID depends on the particular type of cancer that it refers to; for example, for cutaneous melanoma, stage IIID is defined as follows: T4b, N3a/b/c, M0. T4b: Tumor measuring more than 4.0 mm in thickness. Ulceration status: With ulceration. N3a: Four or more clinically occult nodal metastasis (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. N3b: Four or more nodal metastases, at least one of which was clinically detected, or presence of any number of matted nodes. Presence of in-transit, satellite, and/or microsatellite metastases: No. N3c: Two or more clinically occult nodal metastases. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. M0: No evidence of distant metastasis. LDH level is not applicable. (partially adapted from AJCC 8th ed.)	Stage IIID | ajcc_pathologic_stage || Stage IIID | uicc_pathologic_stage	C177556 || C188446	ajcc_pathologic_stage || uicc_pathologic_stage
C	C177537	GDC Value Terminology	C137950	Vosilasarm	An orally bioavailable, non-steroidal selective androgen receptor modulator (SARM), with potential tissue-selective androgenic/anti-androgenic activities. Upon oral administration, vosilasarm acts as an agonist in select tissues, such as skeletal muscle and bone, where it binds to and activates androgen receptors (ARs). In the prostate and breasts, vosilasarm acts as an antagonist and blocks AR activation and AR-mediated cellular proliferation. Therefore, this agent may improve bone formation and muscle mass and strength, and may inhibit both the growth of the prostate in males and AR-dependent breast cancer cell proliferation. Compared to anabolic agents, SARMs have reduced androgenic properties.	Selective Androgen Receptor Modulator RAD140 | therapeutic_agents || Vosilasarm | therapeutic_agents	C1909	therapeutic_agents
C	C177537	GDC Value Terminology	C137998	Smokeless Tobacco Use	Use of smokeless tobacco in any form, e.g., chewing or sniffing.	Tobacco, Smokeless | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C139581	Stage RX	Presence of residual tumor after treatment cannot be assessed.	RX | residual_disease || Stage RX | residual_tumor || Unknown | residual_disease	C139577 || C4809	residual_tumor || residual_disease
C	C177537	GDC Value Terminology	C141478	Not Allowed To Collect	An indicator that specifies that a collection event was not permitted.	Not Allowed To Collect | biospecimen_anatomic_site || Not Allowed To Collect | classification_of_tumor || Not Allowed To Collect | last_known_disease_status || Not Allowed To Collect | method_of_sample_procurement || Not Allowed To Collect | normal_tumor_genotype_snp_match || Not Allowed To Collect | prior_malignancy || Not Allowed To Collect | prior_treatment || Not Allowed To Collect | progression_or_recurrence || Not Allowed To Collect | vital_status || not allowed to collect | ethnicity || not allowed to collect | race || not allowed to collect | vital_status	C16124 || C16564 || C17049 || C171435 || C174459 || C177599 || C177601 || C177617 || C25717 || C70700	prior_treatment || ethnicity || race || biospecimen_anatomic_site || classification_of_tumor || normal_tumor_genotype_snp_match || progression_or_recurrence || last_known_disease_status || vital_status || method_of_sample_procurement
C	C177537	GDC Value Terminology	C14165	Normal	Being approximately average or within certain limits; conforming with or constituting a norm or standard or level or type or social norm.	Normal | imaging_findings || Normal | test_result || Normal | tissue_type	C19697 || C199145 || C36292	tissue_type || imaging_findings || test_result
C	C177537	GDC Value Terminology	C142890	Cinrebafusp Alfa	A bivalent, bispecific fusion protein comprised of an anti-human epidermal growth factor receptor (HER2) monoclonal antibody linked to a CD137-targeting anticalin with potential immunostimulatory and antineoplastic activities. Upon administration of cinrebafusp alfa, CD137 clustering is promoted by bridging CD137-positive T-cells with HER2-positive tumor cells, leading to the recruitment of tumor antigen-specific cytotoxic T-lymphocytes (CTLs). This may result in potent CTL-mediated lysis of HER2-expressing tumor cells. HER2 plays a key role in tumor cell proliferation and tumor vascularization. CD137 is a costimulatory immunoreceptor and a member of the tumor necrosis factor receptor superfamily (TNFRSF). Anticalins are synthetic antigen-binding proteins derived from lipocalins. Structurally dissimilar to antibodies, anticalins are able to bind to smaller antigens and exhibit improved tissue penetration.	Anti-HER2 Monoclonal Antibody/Anti-CD137 Anticalin Bispecific Fusion Protein PRS-343 | therapeutic_agents || Cinrebafusp Alfa | therapeutic_agents	C1909	therapeutic_agents
C	C177537	GDC Value Terminology	C146765	Sovipostobart	A probody composed of ipilimumab, a recombinant human immunoglobulin (Ig) G1 monoclonal antibody directed against the human T-cell receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA4; CTLA-4), linked to a proprietary masking peptide that covers the active antigen-binding site of the antibody through a protease-cleavable linker, with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration of sovipostobart, the masking peptide is cleaved by tumor-associated proteases upon extravasation into the tumor microenvironment (TME). Protease-mediated removal of the linker enables binding of the unmasked monoclonal antibody moiety to CTLA-4, which is expressed on certain T-cells. This inhibits the CTLA4-mediated downregulation of T-cell activation, and leads to both activation of tumor infiltrating T-effector cells and a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. CTLA4, an inhibitory receptor and member of the immunoglobulin superfamily expressed on activated effector T-cells (Teffs) and regulatory T-cells (Tregs), plays a key role in the inhibition of T-cell activity and downregulation of the immune system. The peptide masking of BMS-986249 minimizes binding to CTLA-4 in normal tissues and may reduce systemic toxicity, when compared to ipilimumab. Tumor-associated proteases are present in high concentrations and aberrantly activated in the TME.	CTLA-4-directed Probody BMS-986249 | therapeutic_agents	C1909	therapeutic_agents
C	C177537	GDC Value Terminology	C147577	Upinitatug Rilsodotin	A proprietary antibody-drug conjugate (ADC) composed of upinitatug , a proprietary, humanized monoclonal antibody against human sodium-dependent phosphate transport protein 2B (SLC34A2; NaPi2b), site-specifically linked, via a protease cleavable linker, to the proprietary cytotoxic aurastatin derivative auristatin F-HPA (AF-HPA; auristatin F-hydroxypropylamide), with potential antineoplastic activity. Upinitatug rilsodotin is produced via the proprietary dolaflexin ADC conjugation platform, which promotes the conjugation of between 10 and 15 AF-HPA payload molecules to each XMT-1535 antibody. Upon administration of upinitatug rilsodotin, the antibody moiety targets and binds to NaPi2b expressed on tumor cells. Upon binding, internalization by endosomes/lysosomes, and enzymatic cleavage, the AF-HPA binds to tubulin and inhibits microtubule polymerization, which results in G2/M phase arrest and apoptosis of NaPi2b-expressing tumor cells. NaPi2b, a tumor-associated antigen (TAA), is overexpressed on a variety of cancer cells and plays a key role in the transport of inorganic phosphate (Pi) and the maintenance of phosphate homeostasis.	Antibody-drug Conjugate ADC XMT-1536 | therapeutic_agents	C1909	therapeutic_agents
C	C177537	GDC Value Terminology	C147578	Upinitatug	A proprietary humanized monoclonal antibody against human sodium-dependent phosphate transport protein 2B (SLC34A2; NaPi2b), with potential antineoplastic activity. Upon administration of upinitatug, the antibody targets and binds to NaPi2b expressed on tumor cells. Although the tumor cell killing effects of upinitatug are not established, this binding may induce an antibody-dependent cellular cytotoxicity (ADCC)-mediated immune response against NaPi2b-expressing tumor cells, and/or may inhibit NaPi2b-mediated sodium and phosphate ion cotransport activity and ion-dependent tumor cell signaling. NaPi2b, a tumor-associated antigen (TAA), is overexpressed on a variety of tumor cells. It plays a key role in the transport of inorganic phosphate (Pi) and the maintenance of phosphate homeostasis.	Anti-NaPi2b Monoclonal Antibody XMT-1535 | therapeutic_agents || Upifitamab | therapeutic_agents	C1909	therapeutic_agents
C	C177537	GDC Value Terminology	C148411	T2d TNM Finding	A TNM stage finding term that refers to choroidal and ciliary body melanoma or conjunctival melanoma TNM staging. For choroidal and ciliary body melanoma it means tumor size category 2 with ciliary body involvement and extraocular extension 5 mm or less in largest diameter. For conjunctival melanoma it means caruncular tumor, and more than 1 quadrant of the nonbulbar conjunctiva involved. (from AJCC 8th Ed.)	T2d | ajcc_clinical_t || T2d | ajcc_pathologic_t || T2d | uicc_clinical_t || T2d | uicc_pathologic_t	C177635 || C177636 || C188411 || C188448	ajcc_clinical_t || ajcc_pathologic_t || uicc_clinical_t || uicc_pathologic_t
C	C177537	GDC Value Terminology	C148412	T3d TNM Finding	A TNM finding term that refers to choroidal and ciliary body melanoma, conjunctival melanoma, or retinoblastoma TNM staging. For choroidal and ciliary body melanoma it means tumor size category 3 with ciliary body involvement and extraocular extension 5 mm or less in largest diameter. For conjunctival melanoma it means tumor of any size invading the nasolacrimal duct and/or lacrimal sac and/or paranasal sinuses. For retinoblastoma it means hyphema and/or massive vitreous hemorrhage (clinical) or full-thickness invasion into the outer third of the sclera and/or invasion into or around emissary channels (pathologic). (from AJCC 8th Ed.)	T3d | ajcc_clinical_t || T3d | ajcc_pathologic_t || T3d | uicc_clinical_t || T3d | uicc_pathologic_t	C177635 || C177636 || C188411 || C188448	ajcc_clinical_t || ajcc_pathologic_t || uicc_clinical_t || uicc_pathologic_t
C	C177537	GDC Value Terminology	C148650	Nonstop Mutation	A mutation occurring within the stop codon of a gene that results in a sequence that no longer encodes a stop codon and results in the transcription of non-coding regions downstream of the gene.	Extension | variant_type || Stop Lost | molecular_consequence	C173544 || C97926	variant_type || molecular_consequence
C	C177537	GDC Value Terminology	C15215	Cryosurgery	The use of extreme cold to damage or destroy a body part, pathway, or function. The procedure is performed using small cryogenic probes during surgery, and has recently been applied to solitary sporadic renal tumor lesions.	Ablation, Cryo | treatment_type	C25218	treatment_type
C	C177537	GDC Value Terminology	C15222	Diet	The customary allowance of food and drink taken by a person or an animal from day to day, particularly one especially planned to meet specific requirements of the individual, including or excluding certain items of food; a prescribed course of eating and drinking in which the amount and kind of food, as well as the times at which it is to be taken, are regulated for therapeutic purposes or selected with reference to a particular state of health.	Diet | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C15248	Hemodialysis	A therapeutic procedure used in patients with kidney failure.  It involves the extracorporeal removal of harmful wastes and fluids from the blood using a dialysis machine.  Following the dialysis, the blood is returned to the body.	Renal Dialysis | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C15289	Organ Transplantation	The transfer of an organ, organ part, or tissue from one body to another, for the purpose of replacing the recipient's damaged or failing organ with a working one from the donor. Donors can be living, or cadaveric (dead).	Organ Transplantation | treatment_type || Organ transplant (site) | comorbidities	C16457 || C25218	comorbidities || treatment_type
C	C177537	GDC Value Terminology	C153262	Tinodasertib	A selective mitogen-activated protein kinase (MAPK)-interacting protein kinase (MNK) types 1/2 inhibitor with potential antineoplastic activity. Upon administration, tinodasertib may inhibit MNK1/2-dependent phosphorylation of eukaryotic initiation factor 4E (eIF4E) and interfere with its role in mRNA translation. eIF4E is an oncoprotein that must be phosphorylated before it can promote the proliferation and progression of tumor cells. MNKs are a family of serine/threonine kinases that have been implicated in oncogenic transformation and tumor progression.	MNK1/2 Inhibitor ETC-1907206 | therapeutic_agents	C1909	therapeutic_agents
C	C177537	GDC Value Terminology	C15329	Surgical Procedure	A diagnostic or treatment procedure performed by manual and/or instrumental means, often involving an incision and the removal or replacement of a diseased organ or tissue; of or relating to or involving or used in surgery or requiring or amenable to treatment by surgery.	Surgery, NOS | treatment_type || Surgically Treated | reflux_treatment_type	C177637 || C25218	reflux_treatment_type || treatment_type
C	C177537	GDC Value Terminology	C15356	Whipple Procedure	Surgical removal of part of the pancreas, duodenum, and distal part of the bile duct.  Sometimes, the lower portion of the stomach and the gallbladder are also removed.  This procedure is performed for pancreatic, ampullary, duodenal and distal bile duct cancers.	Whipple | treatment_type || Whipple Procedure | method_of_sample_procurement	C25218 || C70700	treatment_type || method_of_sample_procurement
C	C177537	GDC Value Terminology	C15385	Excisional Biopsy	A surgical procedure in which an entire lesion is removed for microscopic examination.	Biopsy, Excisional | treatment_type || Excisional Biopsy | method_of_diagnosis || Excisional Biopsy | method_of_sample_procurement	C177576 || C25218 || C70700	method_of_diagnosis || treatment_type || method_of_sample_procurement
C	C177537	GDC Value Terminology	C15386	Incisional Biopsy	A surgical procedure in which part of a lesion is removed for microscopic examination.	Biopsy, Incisional | treatment_type || Incisional Biopsy | method_of_diagnosis || Incisional Biopsy | method_of_sample_procurement	C177576 || C25218 || C70700	method_of_diagnosis || treatment_type || method_of_sample_procurement
C	C177537	GDC Value Terminology	C155871	Herpes Simplex Virus Infection	An infection that is caused by herpes simplex virus.	Herpes | comorbidities || Herpes Simplex Virus | aids_risk_factors	C16457 || C177623	comorbidities || aids_risk_factors
C	C177537	GDC Value Terminology	C156076	Autoimmune Atrophic Chronic Gastritis	Chronic atrophic gastritis that is caused by autoimmune destruction of parietal cells in the stomach resulting in hypochlorhydria and decreased production of intrinsic factor.	Autoimmune Atrophic Chronic Gastritis | risk_factors || Autoimmune atrophic chronic gastritis | additional_pathology_findings	C158809 || C17103	additional_pathology_findings || risk_factors
C	C177537	GDC Value Terminology	C156083	High Grade Dysplasia	A subjective characterization of the phenomenon of dysplasia, based on microscopic examination of the architectural and/or cytological changes in a tissue sample, that is determined to be high.	Dysplasia; high grade | additional_pathology_findings || High Grade | dysplasia_degree || High Grade Dysplasia | esophageal_columnar_dysplasia_degree || High Grade Dysplasia | risk_factors	C158809 || C17103 || C177578 || C177641	additional_pathology_findings || risk_factors || dysplasia_degree || esophageal_columnar_dysplasia_degree
C	C177537	GDC Value Terminology	C156084	Low Grade Dysplasia	A subjective characterization of the phenomenon of dysplasia, based on microscopic examination of the architectural and/or cytological changes in a tissue sample, that is determined to be low.	Dysplasia; low grade | additional_pathology_findings || Low Grade | dysplasia_degree || Low Grade Dysplasia | esophageal_columnar_dysplasia_degree || Low Grade Dysplasia | risk_factors	C158809 || C17103 || C177578 || C177641	additional_pathology_findings || risk_factors || dysplasia_degree || esophageal_columnar_dysplasia_degree
C	C177537	GDC Value Terminology	C156176	Falbikitug	A humanized immunoglobulin G1 (IgG1) monoclonal antibody against leukemia inhibitory factor (LIF), with potential immunomodulating and antineoplastic activities. Upon intravenous administration, falbikitug binds to LIF and inhibits LIF signaling by blocking the recruitment of glycoprotein 130 (gp130) to the LIF-LIF receptor (LIFR)-gp130 signaling complex. This inhibits signal transducer and activator of transcription 3 (STAT3) signaling and inhibits tumor cell growth. In addition, the inhibition of LIF signaling abrogates the immunosuppressive tumor microenvironment (TME) by decreasing immunosuppressive M2 macrophages and allows for the activation of natural killer (NK) cells and cytotoxic T-lymphocytes (CTLs) against tumor cells. LIF, a member of the interleukin-6 (IL-6) family of cytokines, is involved in many physiological and pathological processes and plays an important role in both creating the TME and promoting the activity of cancer-initiating cells (CICs). LIF is overexpressed in many tumor cell types and its expression correlates with poor prognosis.	Anti-LIF Monoclonal Antibody MSC-1 | therapeutic_agents	C1909	therapeutic_agents
C	C177537	GDC Value Terminology	C156414	AKR1C3-activated Prodrug AST-3424	A small-molecule nitro-benzene, aldo-keto reductase 1C3 (AKR1C3)-activated prodrug of N,N'-bisethylenephosphoramidate, a DNA bis-alkylating agent, with potential antineoplastic activity. Upon intravenous administration, AKR1C3-activated prodrug AST-3424 is converted to its active form by AKR1C3, which is upregulated in certain tumor cell types while not expressed in normal healthy cells. The active metabolite selectively binds to and alkylates DNA in AKR1C3-overexpressing tumor cells, resulting in DNA base pair mismatching, interstrand crosslinking and inhibition of DNA repair and synthesis, cell-cycle arrest, and apoptosis. As the expression of AKR1C3 is restricted to tumors, AST-3424 is selectively converted to its active metabolite in tumor cells only while its conversion in normal, healthy tissue is absent; this allows for an increased cytotoxic effect of the alkylating agent in tumor cells while decreasing its toxicity.	AKR1C3-activated Prodrug OBI-3424 | therapeutic_agents	C1909	therapeutic_agents
C	C177537	GDC Value Terminology	C156439	REPLI-g X DNA	A genomic DNA sample that has been produced by two rounds of REPLI-g amplification.	Repli-G X | experimental_protocol_type || Repli-G X (Qiagen) DNA | analyte_type	C156434 || C177560	analyte_type || experimental_protocol_type
C	C177537	GDC Value Terminology	C156442	Control Analyte	A biospecimen that is used as a comparator for an experimental sample.	00 | tumor_code_id || Control Analyte | specimen_type || Input Control | chipseq_target	C177584 || C177614 || C70713	tumor_code_id || chipseq_target || specimen_type
C	C177537	GDC Value Terminology	C156445	Derived Cell Line	A biospecimen generated by in vitro culturing of a single cell isolated from a tissue of interest.	Derived Cell Line | specimen_type	C70713	specimen_type
C	C177537	GDC Value Terminology	C156464	Succinate Dehydrogenase-Deficient Renal Cell Carcinoma	A very rare renal cell carcinoma that usually affects young adults. It is characterized by mutations in one of the four subunits of the SDH complex (SDHA, SDHB, SDHC, or SDHD gene). Most frequently, the mutations occur in the SDHB subunit. It has a relatively good prognosis.	Succinate Dehydrogenase-Deficient Renal Cell Carcinoma | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C156480	Trastuzumab Botidotin	An antibody-drug conjugate (ADC) composed of trastuzumab, a humanized monoclonal antibody targeting human epidermal growth factor receptor 2 (EGFR2; HER2; ErbB2), conjugated, via a cleavable linker, to the microtubule inhibitor and auristatin derivative duostatin-5 (Duo-5), with potential antineoplastic activity. Upon administration of trastuzumab botidotin, the trastuzumab moiety targets and binds to HER2 on tumor cells. Upon antibody/antigen binding and internalization, duo-5 binds to tubulin and inhibits its polymerization, which results in cell cycle arrest and induces tumor cell apoptosis. HER2, a tyrosine kinase receptor, is overexpressed by many cancer cell types.	Anti-HER2 Antibody-drug Conjugate A166 | therapeutic_agents	C1909	therapeutic_agents
C	C177537	GDC Value Terminology	C156692	Benmelstobart	A humanized immunoglobulin G1 (IgG1) monoclonal antibody directed against the immunosuppressive ligand programmed cell death-1 (PD-L1; cluster of differentiation 274; CD274), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, benmelstobart specifically targets and binds to PD-L1, preventing the binding and subsequent activation of its receptor, programmed cell death 1 (PD-1; PDCD1; CD279; programmed death-1). This reverses T-cell inactivation caused by PD-L1/PD-1 signaling, increases T-cell expansion and enhances the cytotoxic T-lymphocyte (CTL)-mediated anti-tumor immune response against PD-L1-expressing tumor cells. PD-L1, a transmembrane protein expressed on activated T-cells, is overexpressed in some cancer types and plays a significant role in immune evasion by tumor cells.	Anti-PD-L1 Monoclonal Antibody CBT-502 | therapeutic_agents	C1909	therapeutic_agents
C	C177537	GDC Value Terminology	C156709	Brigimadlin	An orally available inhibitor of murine double minute 2 (MDM2), with potential antineoplastic activity. Upon oral administration, brigimadlin binds to MDM2 protein and prevents its binding to the transcriptional activation domain of the tumor suppressor protein p53. By preventing MDM2-p53 interaction, the transcriptional activity of p53 is restored. This leads to p53-mediated induction of tumor cell apoptosis. Compared to currently available MDM2 inhibitors, the pharmacokinetic properties of BI 907828 allow for more optimal dosing and dose schedules that may reduce myelosuppression, an on-target, dose-limiting toxicity for this class of inhibitors.	MDM2 Inhibitor BI 907828 | therapeutic_agents	C1909	therapeutic_agents
C	C177537	GDC Value Terminology	C15675	Adjuvant Therapy	Any therapy that is administered to augment or stimulate other treatment modalities or to minimize or prevent disease recurrence subsequent to the main treatment plan.	AJ-Adjuvant Therapy | best_overall_response || AJ-Adjuvant Therapy | disease_response || Adjuvant Therapy | timepoint_category	C198201 || C50995 || C94536	timepoint_category || disease_response || best_overall_response
C	C177537	GDC Value Terminology	C156806	New Primary Tumor	A finding indicating the development of a tumor in a patient with a history of a previously diagnosed tumor with a different histopathologic profile in another anatomic site as compared to the most recent one.	New Primary | tumor_descriptor || Prior primary | classification_of_tumor	C166229 || C174459	tumor_descriptor || classification_of_tumor
C	C177537	GDC Value Terminology	C156813	Initial Diagnosis	The first diagnosis of the individual's condition.	Adulthood | timepoint_category || Initial Diagnosis | initial_disease_status	C177616 || C198201	initial_disease_status || timepoint_category
C	C177537	GDC Value Terminology	C156828	Current Reformed Smoker, More than 15 Years	An individual who stopped smoking more than 15 years prior.	Current Reformed Smoker for > 15 yrs | tobacco_smoking_status	C19796	tobacco_smoking_status
C	C177537	GDC Value Terminology	C156829	Current Reformed Smoker Within Past 15 Years	An individual who stopped smoking within the past 15 years.	Current Reformed Smoker for < or = 15 yrs | tobacco_smoking_status	C19796	tobacco_smoking_status
C	C177537	GDC Value Terminology	C156830	Current Reformed Smoker, Years Unknown	An individual who stopped smoking an unknown number of years prior.	Current Reformed Smoker, Duration Not Specified | tobacco_smoking_status	C19796	tobacco_smoking_status
C	C177537	GDC Value Terminology	C157240	Tivumecirnon	An orally available, small molecule antagonist of C-C chemokine receptor type 4 (CCR4) with potential immunomodulatory and antineoplastic activities. Upon oral administration, tivumecirnon inhibits the binding of CCR4 to its signaling molecules, thereby blocking the recruitment of regulatory T-cells (Tregs) to the tumor microenvironment (TME). This may abrogate the immunosuppressive effects of Tregs and promote an effective anti-tumor immune response. CCR4, a chemokine receptor normally expressed on circulating and tissue-resident T-cells, is highly expressed on circulating Tregs and is associated with poor prognosis in certain cancers.	CCR4 Inhibitor FLX475 | therapeutic_agents	C1909	therapeutic_agents
C	C177537	GDC Value Terminology	C157424	Visual Change	An alteration in the visual system of an individual.	Vision Changes | risk_factors || Visual Changes | first_symptom_prior_to_diagnosis	C157233 || C17103	first_symptom_prior_to_diagnosis || risk_factors
C	C177537	GDC Value Terminology	C157429	Sensory Change	An alteration in the perceptual senses an individual.	Sensory Changes | first_symptom_prior_to_diagnosis || Sensory Changes | risk_factors	C157233 || C17103	first_symptom_prior_to_diagnosis || risk_factors
C	C177537	GDC Value Terminology	C157433	Motor / Movement Change	An alteration in the motor/movement of an individual.	Motor / Movement Change | risk_factors || Motor or Movement Changes | first_symptom_prior_to_diagnosis	C157233 || C17103	first_symptom_prior_to_diagnosis || risk_factors
C	C177537	GDC Value Terminology	C157968	Radioactive Iodine Therapy	The use of radioactive iodine to treat disease.	Radioactive Iodine Therapy | treatment_type	C25218	treatment_type
C	C177537	GDC Value Terminology	C158780	Biopsy with Histologic Confirmation	A biopsy with microscopic confirmation.	Biopsy with Histologic Confirmation | evidence_of_recurrence_type || Histologic Confirmation | evidence_of_progression_type || Histologic Confirmation | evidence_of_recurrence_type	C177577 || C198095	evidence_of_recurrence_type || evidence_of_progression_type
C	C177537	GDC Value Terminology	C158782	Convincing Image Source	Radiologic evidence that supports a diagnosis.	Convincing Image Source | evidence_of_progression_type || Convincing Image Source | evidence_of_recurrence_type	C177577 || C198095	evidence_of_recurrence_type || evidence_of_progression_type
C	C177537	GDC Value Terminology	C159717	EBV-Related Lymphoproliferative Disorder	A lymphoproliferative disorder associated with Epstein-Barr virus. This category includes, but is not limited to, Burkitt lymphoma, classic Hodgkin lymphoma, and lymphomas arising in immunocompromised individuals.	EBV Lymphoproliferation | comorbidities || EBV Lymphoproliferation | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C159978	Enristomig	A recombinant, humanized, bispecific antibody targeting both the human programmed death-ligand 1 (PD-L1) and 4-1BB (CD137; tumor necrosis factor receptor superfamily member 9; TNFRSF9), with potential checkpoint inhibitory, immunostimulating and antineoplastic activities. Upon administration, enristomig simultaneously targets and binds to 4-1BB, which is expressed on a variety of leukocyte subsets including activated T-lymphocytes, and PD-L1 expressed on tumor cells. Through 4-1BB binding, enristomig acts as a conditional 4-1BB agonist, resulting in T-cell co-stimulation and enhanced anti-tumor activity. At the same time, Ienristomig prevents PD-L1 from binding to and activating its receptor, programmed cell death 1 (PD-1; PDCD1; CD279; programmed death-1). This abrogates T-cell inhibition, activates antigen-specific T-lymphocytes and enhances cytotoxic T-cell-mediated tumor cell lysis, which may lead to a reduction in tumor growth. PD-L1 binding to PD-1 on activated T-cells inhibits the expansion and survival of CD8-positive T-cells, suppresses the immune system and results in immune evasion. 4-1BB, a surface glycoprotein of the tumor necrosis factor receptor superfamily, is an inducible costimulatory receptor that plays a key role in T-cell proliferation, survival and cytolytic activity.	Anti-PD-L1/4-1BB Bispecific Antibody INBRX-105 | therapeutic_agents	C1909	therapeutic_agents
C	C177537	GDC Value Terminology	C160606	Bocodepsin Besylate	The besylate form of bocodepsin, an orally bioavailable inhibitor of the histone deacetylase (HDAC) subtypes 1 and 4, with potential antineoplastic activity. Upon administration,bocodepsin targets, binds to and inhibits the activity of HDAC1/4. This results in an accumulation of highly acetylated chromatin histones, the induction of chromatin remodeling and an altered pattern of gene expression. This consequently results in a selective transcription of tumor suppressor genes, tumor suppressor protein-mediated inhibition of tumor cell division and an induction of apoptosis in tumor cells that overexpress HDAC1/4. HDAC, which is upregulated in many tumor cell types, deacetylates chromatin histone proteins and plays a key role in transcriptional regulation and cell cycle progression.	Class 1/4 Histone Deacetylase Inhibitor OKI-179 | therapeutic_agents	C1909	therapeutic_agents
C	C177537	GDC Value Terminology	C160691	Lenumlostat	An orally available, small-molecule, irreversible inhibitor of lysyl oxidase homolog 2 (lysyl oxidase-like protein 2; LOXL2) with potential antifibrotic activity. Upon oral administration, the aminomethyl pyridine moiety of lenumlostat interacts with the active site of LOXL2 to form a pseudo-irreversible inhibitory complex, thereby inhibiting the catalytic activity of LOXL2. LOXL2, a secreted glycoprotein, catalyzes the post-translational oxidative deamination of lysine residues on target proteins, including collagen and elastin, leading to the formation of deaminated lysine (allysine). Condensation with other allysines or lysines drives the formation of inter- and intramolecular cross-linkages that impact remodeling of the extracellular matrix (ECM), potentially leading to fibrosis. Inhibition of LOXL2, which is often upregulated in fibrotic tissue, may reduce fibrosis in certain chronic fibrotic diseases.	LOXL2 Inhibitor PAT-1251 | therapeutic_agents	C1909	therapeutic_agents
C	C177537	GDC Value Terminology	C162188	Clonal Hematopoiesis	Cellular proliferation of hematopoietic cells where a substantial proportion of the cells is derived from a single hematopoietic stem cell lineage.	Clonal Hematopoiesis | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C162625	Verzistobart	A fully human Fc-engineered immunoglobulin G1 kappa (IgG1kappa) antibody directed against the inhibitory T-cell receptor T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3; TIM3; hepatitis A virus cellular receptor 2; HAVCR2), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, verzistobart forms a high-affinity interaction with TIM-3 expressed on certain T-cells, thereby preventing the engagement of TIM-3 by its ligands, phosphatidylserine (PtdSer) and galectin-9. This abrogates T-cell inhibition, activates antigen-specific T-lymphocytes and enhances cytotoxic T-cell-mediated tumor cell lysis, which results in a reduction in tumor cell proliferation. Additionally, INCAGN02390 elicits TIM-3 receptor internalization, potentially preventing interactions with other ligands.TIM-3, a transmembrane protein and immune checkpoint receptor expressed on certain lymphocytes, including tumor infiltrating lymphocytes (TILs), is associated with tumor-mediated immune suppression.	Anti-TIM-3 Monoclonal Antibody INCAGN02390 | therapeutic_agents	C1909	therapeutic_agents
C	C177537	GDC Value Terminology	C16273	Alcohol Consumption	Consumption of liquids containing ethanol, including the behaviors associated with drinking the alcohol.	Alcohol Consumption | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C162936	Nezastomig	A bispecific antibody directed against both the tumor-associated antigen (TAA) prostate-specific membrane antigen (PSMA) and the co-stimulatory T-cell-specific surface glycoprotein CD28, with potential immunostimulating and antineoplastic activities. Upon administration of nezastomig this bispecific antibody binds to both CD28 on cytotoxic T-lymphocytes (CTLs) and PSMA found on PSMA-expressing tumor cells. This activates and redirects CTLs to PSMA-expressing tumor cells, which may result in the CTL-mediated cell death of PSMA-expressing tumor cells. PSMA is overexpressed on the surface of metastatic and hormone-refractory prostate cancer cells.	Anti-PSMA/CD28 Bispecific Antibody REGN5678 | therapeutic_agents	C1909	therapeutic_agents
C	C177537	GDC Value Terminology	C163971	Smoking Status Not Documented	Indicates that a person's smoking status has not been recorded.	Smoking history not documented | tobacco_smoking_status	C19796	tobacco_smoking_status
C	C177537	GDC Value Terminology	C163993	EBV Immortalized Lymphocytes	A biospecimen consisting of lymphocytes that have been isolated from whole blood and are then infected in vitro by Epstein-Barr virus (EBV; HHV4). The infected cells are then cultured to select indefinitely proliferating colonies that can be maintained in tissue culture.	EBV Immortalized | specimen_type || EBV Immortalized Lymphocytes | analyte_type	C156434 || C70713	analyte_type || specimen_type
C	C177537	GDC Value Terminology	C163995	Total RNA	A biological sample comprised of all of the RNA collected from an experimental subject.	Total RNA | analyte_type || Total RNA | test_analyte_type || Total RNA | experimental_protocol_type	C156434 || C177557 || C177560	analyte_type || test_analyte_type || experimental_protocol_type
C	C177537	GDC Value Terminology	C164009	Bone Marrow Sample	A biological sample containing components collected from bone marrow of an experimental subject.	Bone Marrow Components NOS | specimen_type || Bone Marrow NOS | specimen_type	C70713	specimen_type
C	C177537	GDC Value Terminology	C164010	Bone Marrow-Derived Fibroblasts	A biological sample containing fibroblasts isolated from the bone marrow of an experimental subject.	Fibroblasts from Bone Marrow | specimen_type	C70713	specimen_type
C	C177537	GDC Value Terminology	C164011	Bone Marrow-Derived Mononuclear Cells	A biological sample containing mononuclear cells isolated from the bone marrow of an experimental subject.	Mononuclear Cells from Bone Marrow | specimen_type	C70713	specimen_type
C	C177537	GDC Value Terminology	C164014	Solid Tissue Specimen	A biological sample containing components collected from non-liquid tissue of an experimental subject.	Solid Tissue | specimen_type	C70713	specimen_type
C	C177537	GDC Value Terminology	C16403	Cell Line	A permanently established cell culture that will proliferate indefinitely given appropriate fresh medium and space.	Cell-Line | biospecimen_anatomic_site || Cell-Line | treatment_anatomic_site	C171435 || C70729	biospecimen_anatomic_site || treatment_anatomic_site
C	C177537	GDC Value Terminology	C164079	Smoking at Diagnosis	An indication that a person was a smoker at the time they received a pathologic diagnosis.	Smoker at Diagnosis | tobacco_smoking_status	C19796	tobacco_smoking_status
C	C177537	GDC Value Terminology	C164120	Occupational Soldering/Welding Smoke Exposure	Occupational exposure to airborne gases and particulates during the operation of a soldering iron or welding machine.	Occupational Soldering/Welding Smoke Exposure | chemical_exposure_type || Work-related smoke, soldering/welding | type_of_smoke_exposure	C164057 || C198092	type_of_smoke_exposure || chemical_exposure_type
C	C177537	GDC Value Terminology	C164213	Recurrent Pyogenic Cholangitis	A recurrent form of cholangitis that is characterized by intrabiliary pigment stone formation, biliary tree stricture and obstruction, and recurrent bouts of cholangitis. There is an association with biliary parasitosis, but evidence supporting these infections in the pathogenesis of recurrent pyogenic cholangitis is inconclusive. The most common causes of death are sepsis, liver failure, or complications from cirrhosis. Patients are also at increased risk of cholangiocarcinoma.	Recurrent Pyogenic Cholangitis | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C165436	Emzadirib	An orally bioavailable inhibitor of the DNA damage repair protein RAD51, with potential antineoplastic and sensitizing activities. Upon oral administration, emzadirib targets, binds to and inhibits the activity of RAD51. This prevents RAD51-mediated DNA damage repair in susceptible tumor cells and induces tumor cell apoptosis. RAD51, the central protein involved in homologous repair (HR) of DNA double-strand breaks (DSBs), is overexpressed in many tumor cell types.	RAD51 Inhibitor CYT-0851 | therapeutic_agents	C1909	therapeutic_agents
C	C177537	GDC Value Terminology	C16606	Gene Deletion	A deletion that results in the loss of a DNA segment encompassing an entire gene sequence.	Transcript Ablation | molecular_consequence	C97926	molecular_consequence
C	C177537	GDC Value Terminology	C166122	Ifebemtinib	An orally bioavailable inhibitor of the non-receptor, cytoplasmic tyrosine kinase protein tyrosine kinase 2 (focal adhesion kinase 1; FAK1; FAK: PTK2) with potential antineoplastic activity. Upon oral administration, ifebemtinib targets and inhibits, in an adenosine triphosphate (ATP)-competitive manner, PTK2. This prevents PTK2-mediated downstream signaling and inhibits migration, proliferation, invasion, and survival in PTK2-overexpressing tumor cells. The cytoplasmic tyrosine kinase PTK2, a signal transducer for integrins overexpressed in various tumor cell types, is involved in tumor cell invasion, migration and proliferation.	Protein Tyrosine Kinase 2 Inhibitor IN10018 | therapeutic_agents	C1909	therapeutic_agents
C	C177537	GDC Value Terminology	C166139	Firastotug	A human monoclonal antibody directed against the human T-cell-expressed receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA4; CTLA-4), with potential immune checkpoint inhibitory and antineoplastic activities. Upon intravenous administration, firastotug targets and binds to CTLA-4 expressed on T-cells and inhibits the CTLA-4-mediated downregulation of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells, thereby killing cancer cells. CTLA-4, an inhibitory receptor and member of the immunoglobulin superfamily (IgSF), plays a key role in the downregulation of the immune system.	Anti-CTLA-4 Monoclonal Antibody ADG116 | therapeutic_agents	C1909	therapeutic_agents
C	C177537	GDC Value Terminology	C169918	Disitamab Vedotin	An antibody-drug conjugate (ADC) composed of trastuzumab, a humanized immunoglobulin G1 (IgG1) monoclonal antibody directed against the tumor-associated antigen (TAA) human epidermal growth factor receptor 2 (EGFR2; HER2; ErbB2), conjugated to the microtubule-disrupting cytotoxic agent monomethyl auristatin E (MMAE), with potential antineoplastic activity. Upon administration of trastuzumab vedotin, the trastuzumab moiety targets and binds to HER2 on the surface of tumor cells. Following internalization, MMAE targets and binds to tubulin, and inhibits microtubule polymerization. This results in G2/M phase cell cycle arrest and apoptosis in HER2-expressing tumor cells. HER2, a tyrosine kinase receptor, is overexpressed by many cancer cell types.	Anti-HER2 Antibody-drug Conjugate RC48 | therapeutic_agents	C1909	therapeutic_agents
C	C177537	GDC Value Terminology	C171138	Bacterial Colonization	The detection of bacteria in or on an anatomic site, medical device or biospecimen.	Colonization, Bacterial | risk_factors || Colonization; bacterial | additional_pathology_findings	C158809 || C17103	additional_pathology_findings || risk_factors
C	C177537	GDC Value Terminology	C171150	Tumor-Associated Lymphocytosis	A laboratory test result indicating an abnormal increase in the number of lymphocytes in a sample from a subject with a tumor.	Tumor-associated Lymphoid Proliferation | risk_factors || Tumor-associated lymphoid proliferation | additional_pathology_findings	C158809 || C17103	additional_pathology_findings || risk_factors
C	C177537	GDC Value Terminology	C172221	Metastasis Present in Distant Lymph Node	An indication that cancer cells have migrated from the primary tumor site and have been detected in adjacent tissues and/or regional lymph nodes.	Distant Nodes | metastasis_at_diagnosis_site	C177625	metastasis_at_diagnosis_site
C	C177537	GDC Value Terminology	C172223	Metastasis Present in Distant Organ	An indication that cancer cells have migrated and spread to one or more organs that are distant from the primary tumor site.	Distant Organ | metastasis_at_diagnosis_site	C177625	metastasis_at_diagnosis_site
C	C177537	GDC Value Terminology	C172230	Family History of BRCA Mutation	An indication that a variant in a BRCA family gene has been identified in a family member of a subject.	BRCA Family History | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C172257	Conditionally Reprogrammed Cells	A cellular sample derived from epithelial cells isolated from a tissue sample that were rapidly expanded in a monolayer culture in the presence of irradiated mouse cells and a Rho kinase (ROCK) inhibitor. Under these conditions the cells are reprogrammed to be more stem-like but the reprogramming is conditional. When the cells are transferred to cultures that mimic in vivo environments they become differentiated and can form structures that resemble the tissue from which they were derived.	2D Classical Conditionally Reprogrammed Cells | specimen_type	C70713	specimen_type
C	C177537	GDC Value Terminology	C172258	Modified Conditionally Reprogrammed Cells	A conditionally reprogrammed cell sample comprised of non-epithelial cells isolated from a tissue sample that were rapidly expanded in monolayer culture under various cell type-specific culture conditions to promote the rapid proliferation of the cell type of interest.	2D Modified Conditionally Reprogrammed Cells | specimen_type	C70713	specimen_type
C	C177537	GDC Value Terminology	C172259	Organoid	A three dimensional mass comprised of a cultured cell or tissue sample that resembles an in vivo tissue or organ. Organoids are grown in vitro from a combination of cells or tissue fragments cultured in medium containing a variety of biochemical factors.	3D Organoid | specimen_type	C70713	specimen_type
C	C177537	GDC Value Terminology	C172260	Air-Liquid Interface Organoid	An organoid grown in vitro where a portion of the cultured cells or tissue is in contact with the medium and another portion is exposed to air. This technique promotes the growth of three dimensional mass resembling a layered tissue or organ, such as the pseudostratified columnar epithelium normally found in the lung and other organs.	3D Air-Liquid Interface Organoid | specimen_type	C70713	specimen_type
C	C177537	GDC Value Terminology	C172261	Neurosphere	A spherical organoid comprised of neural progenitor cells grown in suspension culture in the presence of a combination of growth factors that promote the proliferation neural stem cell.	3D Neurosphere | specimen_type	C70713	specimen_type
C	C177537	GDC Value Terminology	C172264	Buccal Cell Sample	A sample comprised of cells collected from the inside of a subject's cheek.	Buccal Cells | specimen_type	C70713	specimen_type
C	C177537	GDC Value Terminology	C172303	Animal Allergy	An allergic reaction triggered by exposure to animal-associated allergens, includes allergenic factors in venom, saliva and dander.	Allergy, Animal, NOS | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C172304	Food Allergy	An allergic reaction triggered by exposure to allergens found in food; exposure can occur through the skin, respiratory tract or digestive tract.	Allergy, Food, NOS | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C172306	Mold or Dust Allergy	An allergic reaction triggered by exposure to airborne allergens expressed by dust mites or molds.	Allergy, Mold or Dust | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C172307	Venomous Ant Bite Allergy	An allergic reaction triggered by exposure to ant venom, usually as a result of being bitten by a fire ant (Solenopsis spp.).	Allergy, Ant | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C172308	Bee Venom Allergy	An allergic reaction triggered by being exposed to bee venom following a bee sting.	Allergy, Bee | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C172310	Cat Allergy	An allergic reaction triggered by exposure to allergens expressed by cats, includes allergenic factors found in feline saliva and dander.	Allergy, Cat | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C172311	Dog Allergy	An allergic reaction triggered by exposure to allergens expressed by dogs, includes allergenic factors found in canine saliva and dander.	Allergy, Dog | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C172313	Egg Allergy	An allergic reaction triggered by exposure to foodborne allergens found in eggs.	Allergy, Egg | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C172316	Fruit Allergy	An allergic reaction triggered by exposure to foodborne allergens found in fruit.	Allergy, Fruit | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C172317	Meat Allergy	An allergic reaction triggered by exposure to foodborne allergens found in meat.	Allergy, Meat | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C172320	Shellfish Allergy	An allergic reaction triggered by exposure to allergens found in foods containing molluscs, crustaceans or echinoderms.	Allergy, Seafood | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C172321	Wasp Venom Allergy	An allergic reaction triggered by being exposed to wasp venom following a wasp sting.	Allergy, Wasp | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C172394	Boditrectinib	An orally bioavailable, selective pan-tropomyosin-related-kinase (tyrosine receptor kinase; TRK) inhibitor, with potential antineoplastic activity. Upon oral administration, boditrectinib specifically targets and binds to TRK, TRK mutations and fusion proteins containing sequences from neurotrophic tyrosine receptor kinase (NTRK) types 1 (NTRK1; TrkA), 2 (NTRK2; TrkB), and 3 (NTRK3; TrkC). This inhibits neurotrophin-TRK interaction and TRK activation, thereby preventing the activation of downstream signaling pathways and resulting in both the induction of cellular apoptosis and the inhibition of cell growth in tumors that overexpress TRK and/or express NTRK fusion proteins. TRK, a family of receptor tyrosine kinases (RTKs) activated by neurotrophins, is encoded by NTRK family genes. The expression of either mutated forms of, or fusion proteins involving, NTRK family members results in uncontrolled TRK signaling, which plays an important role in tumor cell growth, survival, invasion and treatment resistance.	Pan-TRK Inhibitor NOV1601 | therapeutic_agents	C1909	therapeutic_agents
C	C177537	GDC Value Terminology	C172639	BAP1 Tumor Predisposition Syndrome	A syndrome caused by germline mutations in the BAP1 gene. It is inherited in an autosomal dominant pattern. Individuals carrying heterozygous BAP1 mutations have an increased risk of developing various tumor types, most commonly BAP1-inactivated nevi /melanocytomas of the skin, uveal and cutaneous melanomas, peritoneal and pleural mesotheliomas, clear cell renal cell carcinoma, and basal cell carcinoma. (WHO 2018)	BAP1 Tumor Predisposition Syndrome | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C173377	Dazostinag Disodium	The disodium salt form of dazostinag, an agonist of the stimulator of interferon genes protein (STING; transmembrane protein 173; TMEM173), with potential immunoactivating and antineoplastic activities. Upon intravenous administration, dazostinag targets and binds to STING and activates the STING pathway in immune cells in the tumor microenvironment (TME). This leads to the production of pro-inflammatory cytokines, including interferons (IFNs), enhances the cross-presentation of tumor-associated antigens (TAAs) by dendritic cells (DCs), and induces a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. STING, a transmembrane protein that activates immune cells in the TME, plays a key role in the activation of the innate immune system.	STING Agonist TAK-676 | therapeutic_agents	C1909	therapeutic_agents
C	C177537	GDC Value Terminology	C173496	Peripheral Blood	Blood drawn from a limb.	Peripheral Blood NOS | specimen_type || Peripheral blood | sites_of_involvement	C173263 || C70713	sites_of_involvement || specimen_type
C	C177537	GDC Value Terminology	C173547	Gotistobart	A humanized, pH-sensitive immunoglobulin (Ig) G1 monoclonal antibody directed against the human T-cell-expressed receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA4; CTLA-4; CD152), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, gotistobart targets and binds to CTLA-4 expressed on T-cells and inhibits the CTLA-4-mediated downregulation of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells, thereby killing cancer cells. As ONC-392 is dissociated from CTLA-4 under low pH, it does not cause lysosomal degradation of CTLA-4, preserving CTLA-4 and allowing the recycling of CTLA-4. This may result in more efficient and selective CTLA-4-targeted regulatory T-cell (Treg) depletion within the tumor microenvironment (TME) while preserving CTLA-4 functions outside the TME, thereby reducing toxicities. CTLA-4, an inhibitory receptor and member of the immunoglobulin superfamily (IgSF), plays a key role in the downregulation of the immune system.	Anti-CTLA-4 Monoclonal Antibody ONC-392 | therapeutic_agents	C1909	therapeutic_agents
C	C177537	GDC Value Terminology	C173969	Vopikitug	A monoclonal antibody against CD25 (IL-2R alpha), with potential antineoplastic activity. Upon administration, vopikitug targets and binds to CD25 expressed on tumor-infiltrating regulatory T (Treg) cells. This may deplete Treg cells and prevent immunosuppression, thereby enhancing anti-tumor immune responses. CD25, the alpha chain of the interleukin (IL)-2 receptor, is highly expressed on Treg cells but not on effector T (Teff) cells in tumors.	Anti-CD25 Monoclonal Antibody RO7296682 | therapeutic_agents	C1909	therapeutic_agents
C	C177537	GDC Value Terminology	C174112	Chronic Systemic Steroid Use	An indication that the subject has been using a systemic steroid at the prescribed dose for a long period of time.	Chronic Systemic Steroid Use | comorbidities || Chronic Systemic Steroid Use | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C174113	Cryptococcal Meningitis	A blood borne fungal infection of the membranes surrounding the brain and spinal column (meninges) caused by Cryptococcus, usually C. neoformans or C. gattii. It usually occurs in immunocompromised patients including persons with AIDS, transplant recipients, patients receiving cytotoxic chemotherapy, and patients with hematologic malignancies.	Cryptococcal Meningitis | comorbidities || Cryptococcal Meningitis | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C174114	Lymphocytic Meningitis	Meningitis in which lymphocytes predominate in the cerebrospinal fluid.	Lymphocytic Meningitis | comorbidities || Lymphocytic Meningitis | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C174118	Mixed Adherent Cells in Suspension	A sample comprised of a mixture of cells or clumps of cells, which may have been isolated from normal or tumor tissues, that are maintained in a suspension culture.	Mixed Adherent Suspension | specimen_type	C70713	specimen_type
C	C177537	GDC Value Terminology	C174119	Saliva Sample	A small volume of saliva removed for testing or storage.	Saliva | specimen_type	C70713	specimen_type
C	C177537	GDC Value Terminology	C174120	Esophageal Columnar Dysplasia	A morphologic finding the replacement of the normal lower esophagus squamous epithelium with columnar epithelium.	Esophageal Columnar Dysplasia | dysplasia_type || Esophageal Mucosa Columnar Dysplasia | dysplasia_type	C4086	dysplasia_type
C	C177537	GDC Value Terminology	C174129	Acute Myeloid Leukemia with KMT2A Rearrangement	An acute myeloid leukemia characterized by rearrangement of the KMT2A gene. It affects infants, children and adults. It is usually associated with poor prognosis.	9897/3 | morphology || Acute myeloid leukemia, 11q23 abnormalities | primary_diagnosis || Acute myeloid leukemia, MLL | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C174205	Trastuzumab Vedotin	An antibody-drug conjugate (ADC) composed of trastuzumab, a humanized immunoglobulin G1 (IgG1) monoclonal antibody directed against the tumor-associated antigen (TAA) human epidermal growth factor receptor 2 (EGFR2; HER2; ErbB2), conjugated to the microtubule-disrupting cytotoxic agent monomethyl auristatin E (MMAE), with potential antineoplastic activity. Upon administration of trastuzumab vedotin, the trastuzumab moiety targets and binds to HER2 on the surface of tumor cells. Following internalization, MMAE targets and binds to tubulin, and inhibits microtubule polymerization. This results in G2/M phase cell cycle arrest and apoptosis in HER2-expressing tumor cells. HER2, a tyrosine kinase receptor, is overexpressed by many cancer cell types.	Anti-HER2/MMAE Antibody-drug Conjugate MRG002 | therapeutic_agents	C1909	therapeutic_agents
C	C177537	GDC Value Terminology	C175489	Sonrotoclax	An orally bioavailable inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2), with potential pro-apoptotic and antineoplastic activities. Upon oral administration, sonrotoclax specifically binds to and inhibits the activity of the pro-survival protein Bcl-2. This restores apoptotic processes and inhibits cell proliferation in Bcl-2-overexpressing tumor cells. Bcl-2, a protein that belongs to the Bcl-2 family, is overexpressed in various tumor cell types and plays an important role in the negative regulation of apoptosis. Its tumor expression is associated with increased drug resistance and cancer cell survival.	Bcl-2 Inhibitor BGB-11417 | therapeutic_agents	C1909	therapeutic_agents
C	C177537	GDC Value Terminology	C175520	Dairy or Lactose Intolerance Allergy	An allergic reaction triggered by exposure to allergens found in foods containing lactose or other dairy components.	Allergy, Dairy or Lactose | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C175521	Nut Allergy	An allergic reaction triggered by exposure to allergens found in nuts.	Allergy, Nuts | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C175522	Processed Food Allergy	An allergic reaction triggered by exposure to allergens found in processed foods.	Allergy, Processed Foods | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C17610	Blood Sample	A small volume of blood removed for testing or storage.	Blood Draw | method_of_diagnosis || Blood Draw | method_of_sample_procurement	C177576 || C70700	method_of_diagnosis || method_of_sample_procurement
C	C177537	GDC Value Terminology	C17649	Other	Different than the one(s) previously specified or mentioned.	Other | additional_pathology_findings || Other | alcohol_type || Other | ann_arbor_b_symptoms_described || Other | biospecimen_anatomic_site || Other | comorbidities || Other | diabetes_treatment_type || Other | dysplasia_type || Other | embolic_agent || Other | first_event || Other | immunosuppressive_treatment_type || Other | instrument_model || Other | library_selection || Other | max_tumor_bulk_site || Other | method_of_diagnosis || Other | method_of_sample_procurement || Other | molecular_analysis_method || Other | platform || Other | reason_treatment_ended || Other | relationship_type || Other | sites_of_involvement || Other | therapeutic_agents || Other | timepoint_category || Other | treatment_anatomic_site || Other | treatment_type || Other | type_of_tobacco_used || Other | variant_type || other | classification_of_tumor || other | race	C158809 || C16457 || C166276 || C17049 || C171435 || C173263 || C173544 || C174459 || C177576 || C177610 || C177629 || C18685 || C188396 || C1909 || C19770 || C198107 || C198201 || C25218 || C4086 || C43283 || C45378 || C45902 || C574 || C70700 || C70729 || C83393 || C97229 || C99532	additional_pathology_findings || comorbidities || reason_treatment_ended || race || biospecimen_anatomic_site || sites_of_involvement || variant_type || classification_of_tumor || method_of_diagnosis || instrument_model || type_of_tobacco_used || library_selection || max_tumor_bulk_site || therapeutic_agents || molecular_analysis_method || first_event || timepoint_category || treatment_type || dysplasia_type || ann_arbor_b_symptoms_described || platform || alcohol_type || immunosuppressive_treatment_type || method_of_sample_procurement || treatment_anatomic_site || relationship_type || embolic_agent || diabetes_treatment_type
C	C177537	GDC Value Terminology	C17666	Germline Variation	Any mutation that appears in the gametes and which will therefore be transmitted to the progeny with some frequency.	Germline | variant_origin || Simple Germline Variation | data_type	C172272 || C177604	data_type || variant_origin
C	C177537	GDC Value Terminology	C17747	Disease Progression	A process that manifests as the worsening of a disease over time.	CPD-Clinical Progression | best_overall_response || CPD-Clinical Progression | disease_response || Disease Progression | reason_treatment_ended || Progression | first_event || Progression | timepoint_category	C166276 || C198107 || C198201 || C50995 || C94536	reason_treatment_ended || first_event || timepoint_category || disease_response || best_overall_response
C	C177537	GDC Value Terminology	C17934	Tobacco Smoking	The act of puffing and/or inhaling smoke from a lit cigarette, cigar, or pipe.	Smoking | comorbidities || Tobacco, Smoking | risk_factors	C16457	comorbidities
C	C177537	GDC Value Terminology	C179424	Abnormal Glucose Level Finding	A finding that either fasting or postprandial blood glucose levels are above or below the normal thresholds.	Abnormal Glucose Level | comorbidities || Abnormal Glucose Level | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C179441	Injected Insulin Diabetes Therapy	The use of injected forms of insulin to treat diabetes.	Injected Insulin | diabetes_treatment_type	C99532	diabetes_treatment_type
C	C177537	GDC Value Terminology	C179446	mirVana RNA Isolation	A proprietary, rapid procedure using a glass fiber filter (GFF)-based method to purify total RNA from a sample. The total RNA can then be reapplied to a second GFF to purify small RNAs (miRNAs, siRNAs, and/or snRNAs).	mirVana (Allprep DNA) RNA | experimental_protocol_type	C177560	experimental_protocol_type
C	C177537	GDC Value Terminology	C179448	Oral Hypoglycemic Diabetes Therapy	The use of oral hypoglycemic agents to treat diabetes.	Oral Hypoglycemic | diabetes_treatment_type	C99532	diabetes_treatment_type
C	C177537	GDC Value Terminology	C179646	Endosalpingiosis	A rare condition characterized by the replacement of the epithelium of an organ which is not related to fallopian tube with ectopic fallopian tube-type ciliated epithelium.	Endosalpingiosis | additional_pathology_findings || Endosalpingiosis | risk_factors	C158809 || C17103	additional_pathology_findings || risk_factors
C	C177537	GDC Value Terminology	C17998	Unknown	Not known, observed, recorded; or reported as unknown by the data contributor.	Unknown | adapter_content || Unknown | ajcc_clinical_m || Unknown | ajcc_clinical_n || Unknown | ajcc_clinical_stage || Unknown | ajcc_clinical_t || Unknown | ajcc_pathologic_m || Unknown | ajcc_pathologic_n || Unknown | ajcc_pathologic_stage || Unknown | ajcc_pathologic_t || Unknown | ajcc_staging_system_edition || Unknown | alcohol_history || Unknown | alcohol_intensity || Unknown | alcohol_type || Unknown | anaplasia_present || Unknown | anaplasia_present_type || Unknown | ann_arbor_b_symptoms || Unknown | ann_arbor_clinical_stage || Unknown | ann_arbor_extranodal_involvement || Unknown | ann_arbor_pathologic_stage || Unknown | antigen || Unknown | barretts_esophagus_goblet_cells_present || Unknown | basic_statistics || Unknown | biospecimen_anatomic_site || Unknown | biospecimen_laterality || Unknown | biospecimen_type || Unknown | bone_marrow_malignant_cells || Unknown | burkitt_lymphoma_clinical_variant || Unknown | cause_of_death || Unknown | cause_of_death_source || Unknown | cdc_hiv_risk_factors || Unknown | chemo_concurrent_to_radiation || Unknown | child_pugh_classification || Unknown | chipseq_antibody || Unknown | chipseq_target || Unknown | chromosomal_Unknown | chromosome || Unknown | classification_of_tumor || Unknown | cog_liver_stage || Unknown | cog_neuroblastoma_risk_group || Unknown | cog_renal_stage || Unknown | cog_rhabdomyosarcoma_risk_group || Unknown | columnar_mucosa_present || Unknown | comorbidities || Unknown | comorbidity_method_of_diagnosis || Unknown | diabetes_treatment_type || Unknown | diagnosis_pathologically_confirmed || Unknown | disease_response || Unknown | disease_type || Unknown | distance_normal_to_tumor || Unknown | dysplasia_degree || Unknown | dysplasia_type || Unknown | ecog_performance_status || Unknown | eln_risk_classification || Unknown | enneking_msts_grade || Unknown | enneking_msts_metastasis || Unknown | enneking_msts_stage || Unknown | enneking_msts_tumor_site || Unknown | environmental_tobacco_smoke_exposure || Unknown | esophageal_columnar_dysplasia_degree || Unknown | esophageal_columnar_metaplasia_present || Unknown | ethnicity || Unknown | exposure_duration || Unknown | exposure_source || Unknown | figo_stage || Unknown | first_symptom_prior_to_diagnosis || Unknown | fragmentation_enzyme || Unknown | gastric_esophageal_junction_involvement || Unknown | gene_symbol || Unknown | goblet_cells_columnar_mucosa_present || Unknown | haart_treatment_indicator || Unknown | hepatitis_sustained_virological_response || Unknown | histone_family || Unknown | histone_variant || Unknown | hormonal_contraceptive_type || Unknown | hormonal_contraceptive_use || Unknown | hormone_replacement_therapy_type || Unknown | hysterectomy_margins_involved || Unknown | hysterectomy_type || Unknown | igcccg_stage || Unknown | imaging_result || Unknown | immunosuppressive_treatment_type || Unknown | initial_disease_status || Unknown | inpc_grade || Unknown | inpc_histologic_group || Unknown | inrg_stage || Unknown | inss_stage || Unknown | instrument_model || Unknown | irs_group || Unknown | irs_stage || Unknown | ishak_fibrosis_score || Unknown | iss_stage || Unknown | karnofsky_performance_status || Unknown | kmer_content || Unknown | laboratory_test || Unknown | largest_extrapelvic_peritoneal_focus || Unknown | laterality || Unknown | lost_to_followup || Unknown | lymph_node_involved_site || Unknown | lymph_node_involvement || Unknown | lymphatic_invasion_present || Unknown | margin_status || Unknown | medulloblastoma_molecular_classification || Unknown | menopause_status || Unknown | metaplasia_present || Unknown | metastasis_at_diagnosis || Unknown | metastasis_at_diagnosis_site || Unknown | method_of_diagnosis || Unknown | method_of_sample_procurement || Unknown | micropapillary_features || Unknown | mismatch_repair_mutation || Unknown | mitosis_karyorrhexis_index || Unknown | molecular_analysis_method || Unknown | morphology || Unknown | non_nodal_regional_disease || Unknown | non_nodal_tumor_deposits || Unknown | normal_tumor_genotype_snp_match || Unknown | ovarian_specimen_status || Unknown | ovarian_surface_involvement || Unknown | overrepresented_sequences || Unknown | per_base_n_content || Unknown | per_base_sequence_content || Unknown | per_base_sequence_quality || Unknown | per_sequence_gc_content || Unknown | per_sequence_quality_score || Unknown | per_tile_sequence_quality || Unknown | perineural_invasion_present || Unknown | peripancreatic_lymph_nodes_positive || Unknown | peritoneal_fluid_cytological_status || Unknown | ploidy || Unknown | pregnancy_outcome || Unknown | pregnant_at_diagnosis || Unknown | premature_at_birth || Unknown | preservation_method || Unknown | primary_diagnosis || Unknown | primary_site || Unknown | prior_treatment || Unknown | procedures_performed || Unknown | progression_or_recurrence || Unknown | progression_or_recurrence_anatomic_site || Unknown | progression_or_recurrence_type || Unknown | race || Unknown | reflux_treatment_type || Unknown | relationship_primary_diagnosis || Unknown | relationship_type || Unknown | risk_factor_treatment || Unknown | risk_factors || Unknown | satellite_nodule_present || Unknown | second_gene_symbol || Unknown | secondhand_smoke_as_child || Unknown | sequence_duplication_levels || Unknown | sequence_length_distribution || Unknown | site_of_resection_or_biopsy || Unknown | sites_of_involvement || Unknown | smoking_frequency || Unknown | specimen_type || Unknown | supratentorial_localization || Unknown | synchronous_malignancy || Unknown | target_capture_kit || Unknown | test_analyte_type || Unknown | test_result || Unknown | test_units || Unknown | therapeutic_agents || Unknown | time_between_waking_and_first_smoke || Unknown | tissue_or_organ_of_origin || Unknown | tissue_type || Unknown | tobacco_smoking_status || Unknown | transglottic_extension || Unknown | treatment_anatomic_site || Unknown | treatment_effect || Unknown | treatment_effect_indicator || Unknown | treatment_frequency || Unknown | treatment_intent_type || Unknown | treatment_outcome || Unknown | treatment_type || Unknown | tumor_confined_to_organ_of_origin || Unknown | tumor_descriptor || Unknown | tumor_focality || Unknown | tumor_grade || Unknown | tumor_regression_grade || Unknown | type_of_smoke_exposure || Unknown | uicc_clinical_m || Unknown | uicc_clinical_n || Unknown | uicc_clinical_stage || Unknown | uicc_clinical_t || Unknown | uicc_pathologic_m || Unknown | uicc_pathologic_n || Unknown | uicc_pathologic_stage || Unknown | uicc_pathologic_t || Unknown | uicc_staging_system_edition || Unknown | variant_origin || Unknown | variant_type || Unknown | vascular_invasion_present || Unknown | vascular_invasion_type || Unknown | viral_hepatitis_serologies || Unknown | vital_status || Unknown | who_cns_grade || Unknown | who_nte_grade || Unknown | wilms_tumor_histologic_subtype || Unknown | zygosity || unknown | gender || unknown | prior_malignancy || unknown | progression_or_recurrence || unknown | relationship_gender || unknown | relative_with_cancer_history || unknown | treatment_or_therapy || unknown | vital_status	C102562 || C105721 || C106304 || C106317 || C106541 || C111073 || C112400 || C121007 || C123560 || C125738 || C126378 || C127768 || C127772 || C129439 || C13202 || C133427 || C133706 || C139007 || C140258 || C140259 || C140262 || C140266 || C141342 || C15256 || C15599 || C156421 || C156422 || C157233 || C157410 || C157425 || C158874 || C159824 || C160720 || C160827 || C160996 || C16124 || C161320 || C16165 || C162221 || C164057 || C16457 || C16515 || C16564 || C166229 || C16687 || C17001 || C17049 || C17103 || C171253 || C17140 || C171435 || C173263 || C173544 || C17357 || C173595 || C174459 || C175524 || C176287 || C176708 || C176985 || C177549 || C177550 || C177555 || C177556 || C177557 || C177558 || C177559 || C177561 || C177562 || C177564 || C177565 || C177566 || C177567 || C177568 || C177570 || C177571 || C177572 || C177576 || C177578 || C177583 || C177585 || C177586 || C177587 || C177588 || C177589 || C177590 || C177591 || C177592 || C177593 || C177594 || C177595 || C177597 || C177598 || C177599 || C177600 || C177601 || C177603 || C177604 || C177605 || C177606 || C177607 || C177608 || C177609 || C177610 || C177611 || C177612 || C177613 || C177614 || C177616 || C177619 || C177620 || C177621 || C177622 || C177624 || C177625 || C177626 || C177627 || C177628 || C177630 || C177631 || C177632 || C177633 || C177634 || C177635 || C177636 || C177637 || C177638 || C177640 || C177641 || C178243 || C178276 || C178286 || C178287 || C178288 || C178289 || C185264 || C185265 || C185266 || C185267 || C185268 || C185269 || C185270 || C185271 || C185272 || C185273 || C185274 || C185275 || C188372 || C188406 || C188408 || C188409 || C188411 || C188415 || C188429 || C188446 || C188448 || C18849 || C18919 || C1909 || C19232 || C19697 || C19770 || C19796 || C198206 || C25185 || C25218 || C25294 || C25717 || C268 || C28013 || C28076 || C29878 || C2991 || C33027 || C3420 || C35529 || C36037 || C36292 || C38032 || C4086 || C45824 || C45902 || C49236 || C50995 || C54398 || C574 || C67415 || C70700 || C70713 || C70729 || C81229 || C81239 || C83280 || C83315 || C83393 || C85416 || C89081 || C90491 || C92808 || C93431 || C95149 || C99532	inpc_grade || ecog_performance_status || tumor_regression_grade || mitosis_karyorrhexis_index || menopause_status || igcccg_stage || premature_at_birth || child_pugh_classification || margin_status || figo_stage || alcohol_intensity || perineural_invasion_present || vascular_invasion_present || medulloblastoma_molecular_classification || chromosome || inrg_stage || mismatch_repair_mutation || iss_stage || enneking_msts_stage || enneking_msts_grade || enneking_msts_tumor_site || enneking_msts_metastasis || chemo_concurrent_to_radiation || hysterectomy_type || hormone_replacement_therapy_type || site_of_resection_or_biopsy || tissue_or_organ_of_origin || first_symptom_prior_to_diagnosis || hormonal_contraceptive_use || tumor_focality || primary_site || lost_to_followup || lymphatic_invasion_present || satellite_nodule_present || transglottic_extension || prior_treatment || synchronous_malignancy || haart_treatment_indicator || metastasis_at_diagnosis || type_of_smoke_exposure || comorbidities || fragmentation_enzyme || ethnicity || tumor_descriptor || histone_family || ploidy || race || risk_factors || second_gene_symbol || environmental_tobacco_smoke_exposure || biospecimen_anatomic_site || sites_of_involvement || variant_type || gender || gene_symbol || classification_of_tumor || peritoneal_fluid_cytological_status || cause_of_death_source || imaging_result || morphology || irs_group || irs_stage || ajcc_clinical_stage || ajcc_pathologic_stage || test_analyte_type || ann_arbor_clinical_stage || ann_arbor_pathologic_stage || ajcc_staging_system_edition || eln_risk_classification || comorbidity_method_of_diagnosis || inpc_histologic_group || who_cns_grade || who_nte_grade || wilms_tumor_histologic_subtype || progression_or_recurrence_anatomic_site || supratentorial_localization || distance_normal_to_tumor || method_of_diagnosis || dysplasia_degree || target_capture_kit || ann_arbor_b_symptoms || ann_arbor_extranodal_involvement || bone_marrow_malignant_cells || burkitt_lymphoma_clinical_variant || columnar_mucosa_present || diagnosis_pathologically_confirmed || esophageal_columnar_metaplasia_present || gastric_esophageal_junction_involvement || barretts_esophagus_goblet_cells_present || goblet_cells_columnar_mucosa_present || hysterectomy_margins_involved || metaplasia_present || non_nodal_regional_disease || non_nodal_tumor_deposits || normal_tumor_genotype_snp_match || ovarian_surface_involvement || progression_or_recurrence || risk_factor_treatment || variant_origin || biospecimen_laterality || ajcc_clinical_m || ajcc_pathologic_m || ovarian_specimen_status || viral_hepatitis_serologies || instrument_model || ajcc_clinical_n || ajcc_pathologic_n || chipseq_antibody || chipseq_target || initial_disease_status || pregnant_at_diagnosis || histone_variant || primary_diagnosis || relationship_gender || cdc_hiv_risk_factors || metastasis_at_diagnosis_site || secondhand_smoke_as_child || smoking_frequency || time_between_waking_and_first_smoke || cog_liver_stage || cog_neuroblastoma_risk_group || cog_renal_stage || cog_rhabdomyosarcoma_risk_group || hepatitis_sustained_virological_response || ajcc_clinical_t || ajcc_pathologic_t || reflux_treatment_type || treatment_effect_indicator || progression_or_recurrence_type || esophageal_columnar_dysplasia_degree || relationship_primary_diagnosis || peripancreatic_lymph_nodes_positive || anaplasia_present || anaplasia_present_type || vascular_invasion_type || largest_extrapelvic_peritoneal_focus || adapter_content || basic_statistics || kmer_content || overrepresented_sequences || per_base_n_content || per_base_sequence_content || per_base_sequence_quality || per_sequence_gc_content || per_sequence_quality_score || per_tile_sequence_quality || sequence_duplication_levels || sequence_length_distribution || exposure_source || uicc_clinical_m || uicc_clinical_n || uicc_clinical_stage || uicc_clinical_t || uicc_pathologic_m || uicc_pathologic_n || uicc_pathologic_stage || uicc_pathologic_t || history_of_tumor || prior_malignancy || treatment_outcome || therapeutic_agents || preservation_method || tissue_type || molecular_analysis_method || tobacco_smoking_status || uicc_staging_system_edition || laterality || treatment_type || laboratory_test || vital_status || antigen || karnofsky_performance_status || tumor_grade || relative_with_cancer_history || disease_type || lymph_node_involved_site || chromosomal_lymph_node_involvement || tumor_confined_to_organ_of_origin || test_result || treatment_effect || dysplasia_type || zygosity || alcohol_type || treatment_or_therapy || disease_response || treatment_intent_type || immunosuppressive_treatment_type || test_units || method_of_sample_procurement || specimen_type || treatment_anatomic_site || alcohol_history || cause_of_death || exposure_duration || biospecimen_type || relationship_type || inss_stage || treatment_frequency || pregnancy_outcome || hormonal_contraceptive_type || procedures_performed || ishak_fibrosis_score || diabetes_treatment_type
C	C177537	GDC Value Terminology	C18009	Tumor Tissue	A tumor sample, or entire tumor that is removed for microscopic examination.	Involved Tissue, NOS | biospecimen_type || Tumor | tissue_type	C19697 || C83315	tissue_type || biospecimen_type
C	C177537	GDC Value Terminology	C18059	Tobacco Use	Use of tobacco in any form, e.g., smoking, chewing or sniffing.	Tobacco, NOS | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C184754	Diabetes Is Controlled by Diet	An indication that a subject with diabetes is able to control symptoms by modifying their diet.	Diet Controlled Diabetes | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C184766	Diabetes Is Controlled by Insulin	An indication that a subject with diabetes is able to control symptoms using insulin-based therapies.	Insulin Controlled Diabetes | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C184773	Personal History of Liver Toxicity due to Non-Infectious Cause	An indication that a subject a has a history that includes symptoms of liver toxicity that is not due to an infection.	Liver Toxicity (Non-Infectious) | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C184782	Personal History of Other Cancer Within 5 Years	An individual history of a cancer, other than those listed, within 5 years of the current cancer diagnosis.	Other Cancer Within 5 Years | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C184785	Personal History of Other Nonmalignant Systemic Disease	An individual history of a nonmalignant systemic disease, other than those listed.	Other Nonmalignant Systemic Disease | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C184786	Personal History of Other Pulmonary Complications	An individual history of a pulmonary complication, other than those listed.	Other Pulmonary Complications | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C184791	Personal History of Renal Failure Requiring Dialysis	An indication that a subject a history of renal failure that required treatment with dialysis.	Renal Failure (Requiring Dialysis) | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C184804	SRA-XML Format	An XML-based electronic file format used by the NCBI Sequence Read Archive (SRA) and the European Nucleotide Archive (ENA) to store raw sequencing data from next generation sequencing platforms and any corresponding sequence analysis data and associated metadata for the study, sample and experiment.	SRA XML | data_format	C42761	data_format
C	C177537	GDC Value Terminology	C184807	TARGET Data Coordinating Center Archive	A storage location for historical digital data from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) project data coordinating center.	TARGET DCC Archive | data_type	C172272	data_type
C	C177537	GDC Value Terminology	C184808	TCGA Data Coordinating Center Archive	A storage location for historical digital data from The Cancer Genome Atlas (TCGA) project data coordinating center.	TCGA DCC Archive | data_type	C172272	data_type
C	C177537	GDC Value Terminology	C188294	T1b1 TNM Finding	A general term that refers to a TNM finding of a primary tumor limited to the site of growth. The definition of T1b1 TNM finding depends on the specific type of cancer to which it refers: for example, for cervical carcinoma it indicates measured stromal invasion measuring more than 5 mm in depth and equal or less than 2 cm in greatest dimension.	T1b1 | ajcc_clinical_t || T1b1 | ajcc_pathologic_t || T1b1 | uicc_clinical_t || T1b1 | uicc_pathologic_t	C177635 || C177636 || C188411 || C188448	ajcc_clinical_t || ajcc_pathologic_t || uicc_clinical_t || uicc_pathologic_t
C	C177537	GDC Value Terminology	C188295	T1b2 TNM Finding	A general term that refers to a TNM finding of a primary tumor limited to the site of growth. The definition of T1b2 TNM finding depends on the specific type of cancer to which it refers: for example, for cervical carcinoma it indicates stromal invasion measuring more than 2 cm and equal or less than 4 cm in greatest dimension.	T1b2 | ajcc_clinical_t || T1b2 | ajcc_pathologic_t || T1b2 | uicc_clinical_t || T1b2 | uicc_pathologic_t	C177635 || C177636 || C188411 || C188448	ajcc_clinical_t || ajcc_pathologic_t || uicc_clinical_t || uicc_pathologic_t
C	C177537	GDC Value Terminology	C188296	T2a1 TNM Finding	A general term that refers to a TNM finding of a primary tumor with direct invasion of adjacent structures. The definition of T2a1 TNM finding depends on the specific type of cancer to which it refers: for example, for cervical carcinoma it indicates involvement limited to the upper two-thirds of the vagina without parametrial invasion measuring 4.0 cm or less in greatest dimension.	T2a1 | ajcc_clinical_t || T2a1 | ajcc_pathologic_t || T2a1 | uicc_clinical_t || T2a1 | uicc_pathologic_t	C177635 || C177636 || C188411 || C188448	ajcc_clinical_t || ajcc_pathologic_t || uicc_clinical_t || uicc_pathologic_t
C	C177537	GDC Value Terminology	C188297	T2a2 TNM Finding	A general term that refers to a TNM finding of a primary tumor with direct invasion of adjacent structures. The definition of T2a2 TNM finding depends on the specific type of cancer to which it refers: for example, for cervical carcinoma it indicates involvement limited to the upper two-thirds of the vagina without parametrial invasion measuring more than 4.0 cm in greatest dimension.	T2a2 | ajcc_clinical_t || T2a2 | ajcc_pathologic_t || T2a2 | uicc_clinical_t || T2a2 | uicc_pathologic_t	C177635 || C177636 || C188411 || C188448	ajcc_clinical_t || ajcc_pathologic_t || uicc_clinical_t || uicc_pathologic_t
C	C177537	GDC Value Terminology	C188298	T4e TNM Finding	A general term that refers to a TNM finding of a primary tumor with direct invasion of adjacent structures. The definition of T4e TNM finding depends on the specific type of cancer that it refers: for example, for choroidal and ciliary body melanoma it indicates any tumor size category with extraocular extension more than 5 mm in largest diameter.	T4e | ajcc_clinical_t || T4e | ajcc_pathologic_t || T4e | uicc_clinical_t || T4e | uicc_pathologic_t	C177635 || C177636 || C188411 || C188448	ajcc_clinical_t || ajcc_pathologic_t || uicc_clinical_t || uicc_pathologic_t
C	C177537	GDC Value Terminology	C188299	Stage M2	A stage term that refers to central nervous system embryonal tumor or ependymoma in which visible metastasis is present in the brain.	M2 | ajcc_pathologic_m || M2 | uicc_pathologic_m	C177607 || C188415	ajcc_pathologic_m || uicc_pathologic_m
C	C177537	GDC Value Terminology	C188301	M1d TNM Finding	A TNM finding indicating the spread of cancer to distant anatomic sites. The definition of M1d TNM finding depends on the specific type of cancer to which it refers: for example, for cutaneous melanoma it indicates distant metastasis to CNS with or without M1a, M1b, or M1c sites of disease. LDH level not recorded or unspecified.	M1d | ajcc_pathologic_m || M1d | uicc_pathologic_m	C177607 || C188415	ajcc_pathologic_m || uicc_pathologic_m
C	C177537	GDC Value Terminology	C188353	Staphylococcal Osteomyelitis	Osteomyelitis resulting from an infection with Staphylococcus.	Staph Osteomyelitis | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C191741	Urinary Tract	The parts of the urinary system that discharge urine. These include the renal pelvis, ureter, bladder, and urethra.	Urinary Tract | biospecimen_anatomic_site || Urinary Tract | treatment_anatomic_site	C171435 || C70729	biospecimen_anatomic_site || treatment_anatomic_site
C	C177537	GDC Value Terminology	C19315	Primary Cell Culture	The cells taken from a tissue source, and their progeny, grown in culture before subdivision and transfer to a sub culture.	Human Original Cells | specimen_type	C70713	specimen_type
C	C177537	GDC Value Terminology	C20216	Adherent Culture	A type of culture in which cells grow as a monolayer that is attached to the culture substrate.	Adherent Cell Line | specimen_type	C70713	specimen_type
C	C177537	GDC Value Terminology	C20217	Suspension Culture	A type of culture in which cells, or aggregates of cells, multiply while suspended in liquid medium.	Liquid Suspension Cell Line | specimen_type	C70713	specimen_type
C	C177537	GDC Value Terminology	C25153	Autopsy	A postmortem examination of the body that includes an examination of the internal organs and structures after dissection to determine the cause of death and the nature of pathological changes.	Autopsy | cause_of_death_source || Autopsy | method_of_diagnosis || Autopsy | method_of_sample_procurement	C176287 || C177576 || C70700	cause_of_death_source || method_of_diagnosis || method_of_sample_procurement
C	C177537	GDC Value Terminology	C26323	Hematologic and Lymphocytic Disorder	A neoplastic or non-neoplastic disorder that affects the production and proliferation of the hematopoietic cells including lymphoid cells, the synthesis of hemoglobin, and/or the mechanisms of coagulation.	Hematologic Disorder, NOS | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C26691	Adrenocortical Insufficiency	An endocrine or hormonal disorder that occurs when the adrenal cortex does not produce enough of the hormone cortisol and in some cases, the hormone aldosterone. It may be due to a disorder of the adrenal cortex (Addison's disease or primary adrenal insufficiency) or to inadequate secretion of ACTH by the pituitary gland (secondary adrenal insufficiency).	Adrenocortical Insufficiency | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C26696	Anxiety	Apprehension of danger and dread accompanied by restlessness, tension, tachycardia, and dyspnea unattached to a clearly identifiable stimulus.	Anxiety | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C26713	Cataract	Partial or complete opacity of the crystalline lens of one or both eyes that decreases visual acuity and eventually results in blindness. Some cataracts appear in infancy or in childhood, but most develop in older individuals. (Sternberg Diagnostic Surgical Pathology, 3rd ed.)	Cataracts | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C26714	Celiac Disease	An autoimmune genetic disorder with an unknown pattern of inheritance that primarily affects the digestive tract. It is caused by intolerance to dietary gluten. Consumption of gluten protein triggers an immune response which damages small intestinal villi and prevents adequate absorption of nutrients. Clinical signs include abdominal cramping, diarrhea or constipation and weight loss. If untreated, the clinical course may progress to malnutrition, anemia, osteoporosis and an increased risk of intestinal malignancies. However, the prognosis is favorable with successful avoidance of gluten in the diet.	Celiac Disease | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C26725	Common Variable Immunodeficiency	A primary immunodeficiency characterized by low levels or absence of all the immunoglobulin classes and lack of B-lymphocytes or plasma cells. It results in recurrent bacterial infections. Complications include autoimmune phenomena and cancer development.	Common Variable Immunodeficiency | comorbidities || Common variable immune deficiency (CVID) | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C26729	Connective Tissue Disorder	A non-neoplastic or neoplastic disorder that affects the connective tissue.	Connective Tissue Disorder | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C26732	Coronary Artery Disease	Narrowing of the coronary arteries due to fatty deposits inside the arterial walls. The diagnostic criteria may include documented history of any of the following: documented coronary artery stenosis greater than or equal to 50% (by cardiac catheterization or other modality of direct imaging of the coronary arteries); previous coronary artery bypass surgery (CABG); previous percutaneous coronary intervention (PCI); previous myocardial infarction. (ACC)	Coronary Artery Disease | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C26744	Dermatomyositis	Inflammation of the skin and muscle.	Dermatomyosis | comorbidities || Dermatomyosis | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C26747	Type 2 Diabetes Mellitus	A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity.	Diabetes, Type II | comorbidities || Diabetes, Type II | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C26748	Diabetic Neuropathy	A chronic, pathological complication associated with diabetes mellitus, where nerve damages are incurred due to diabetic microvascular injury involving small blood vessels that supply these nerves, resulting in peripheral and/or autonomic nerve dysfunction.	Diabetic Neuropathy | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C26752	Diverticulitis	An infection that develops in the diverticula of the intestinal tract. Signs and symptoms include abdominal pain, fever, and leukocytosis.	Diverticulitis | comorbidities || Diverticulitis | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C26780	Gastritis	Inflammation of the stomach.	Gastritis | comorbidities || Gastritis | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C26781	Gastroesophageal Reflux Disease	A chronic disorder characterized by reflux of the gastric and/or duodenal contents into the distal esophagus. It is usually caused by incompetence of the lower esophageal sphincter. Symptoms include heartburn and acid indigestion. It may cause injury to the esophageal mucosa.	GERD | comorbidities || Gastroesophageal Reflux Disease | comorbidities || Reflux Disease | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C26782	Glaucoma	Increased pressure in the eyeball due to obstruction of the outflow of aqueous humor.	Glaucoma | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C26786	Gonadal Disorder	A non-neoplastic or neoplastic disorder that affects the testis or the ovary.	Gonadal Dysfunction | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C26797	Hyperglycemia	Abnormally high level of glucose in the blood.	Hyperglycemia | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C26800	Hypothyroidism	Abnormally low levels of thyroid hormone.	Hypothyroidism | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C26808	Acute Renal Failure	Sudden and sustained deterioration of the kidney function characterized by decreased glomerular filtration rate, increased serum creatinine or oliguria.	Acute Renal Failure | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C26862	Polycystic Ovary Syndrome	A disorder that manifests as multiple cysts on the ovaries. It results in hormonal imbalances and leads to irregular and abnormal menstrual periods, excess growth of hair, acne eruptions and obesity.	Polycystic Ovarian Syndrome (PCOS) | comorbidities || Polycystic Ovarian Syndrome (PCOS) | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C26869	Pulmonary Fibrosis	Chronic progressive interstitial lung disorder characterized by the replacement of the lung tissue by connective tissue, leading to progressive dyspnea, respiratory failure, or right heart failure. Causes include chronic inflammatory processes, exposure to environmental irritants, radiation therapy, autoimmune disorders, certain drugs, or it may be idiopathic (no identifiable cause).	Pulmonary Fibrosis | comorbidities || Pulmonary interstitial fibrosis | additional_pathology_findings	C158809 || C16457	additional_pathology_findings || comorbidities
C	C177537	GDC Value Terminology	C26882	Sialadenitis	An acute or chronic inflammatory process affecting a salivary gland. Signs and symptoms include pain and tenderness in the affected area.	Sialadenitis | additional_pathology_findings || Sialadenitis | risk_factors	C158809 || C17103	additional_pathology_findings || risk_factors
C	C177537	GDC Value Terminology	C26883	Sjogren Syndrome	An autoimmune disorder affecting the salivary and lacrimal glands. Morphologically, it is characterized by the presence of lymphocytic and plasmacytic infiltrates which cause destruction of these glands. It results in dry mouth and dry eyes. It may be associated with the presence of other autoimmune disorders, including rheumatoid arthritis and lupus erythematosus.	Sjogren's Syndrome | comorbidities || Sjogren's Syndrome | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C26884	Sleep Apnea	Cessation of breathing for short periods during sleep. It is classified as obstructive, central, or mixed obstructive-central. It can occur at any age but it is more frequent in people over forty. Risk factors include male sex and obesity.	Sleep apnea | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C27006	Interstitial Pneumonia	Inflammation of interstitial lung tissue, usually associated with infection.	Interstitial Pneumontis or ARDS | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C27038	Idiopathic Hypereosinophilic Syndrome	A syndrome characterized by persistent eosinophilia, for which no underlying cause can be found, and which is associated with signs of organ involvement and dysfunction.  This term has often been applied to cases of chronic eosinophilic leukemia.  (WHO, 2001)	9964/3 | morphology || Hypereosinophilic syndrome | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C27083	Blood Clot	An aggregation of blood factors, primarily platelets and fibrin with entrapment of cellular elements, frequently causing vascular obstruction at the point of its formation.	Blood Clots | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C27121	Helicobacter Pylori-Associated Gastritis	Inflammation of the stomach that is associated with Helicobacter Pylori.	Helicobacter Pylori-Associated Gastritis | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C27153	Lupus Erythematosus	An autoimmune, connective tissue chronic inflammatory disorder affecting the skin, joints, kidneys, lungs, heart, and the peripheral blood cells. It is more commonly seen in women than men. Variants include discoid and systemic lupus erythematosus.	Lupus | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C27191	Hashimoto Thyroiditis	An autoimmune disorder caused by the production of autoantibodies against thyroid tissue. There is progressive destruction of the thyroid follicles leading to hypothyroidism.	Hashimoto's Thyroiditis | comorbidities || Hashimoto's Thyroiditis | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C27204	Rheumatologic Disorder	Inflammatory and degenerative diseases of connective tissue structures, such as arthritis.	Rheumatologic Disease | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C27314	Mycobacterium Avium Complex Lymphadenitis	Lymph node infection by Mycobacterium avium or Mycobacterium intracellulare. It most often affects children and usually presents with cervical lymph node enlargement. It generally follows a benign clinical course.	MAI | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C27566	Non-Neoplastic Thyroid Gland Disorder	A non-neoplastic disorder that affects the thyroid gland.  Representative examples include hyperthyroidism, hypothyroidism, thyroiditis, and thyroid gland abscess.	Thyroid Disease, Non-Cancer | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C27582	Central Nervous System Infectious Disorder	An infectious process that affects the brain and/or spinal cord. Representative examples include encephalitis, poliomyelitis, arachnoiditis, and meningitis.	CNS Infection | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C27753	Acute Myeloid Leukemia Not Otherwise Specified	Acute myeloid leukemias that do not fulfill the criteria for inclusion in the group of acute myeloid leukemias which have recurrent genetic abnormalities or myelodysplastic changes, or are therapy-related.  This category includes entities classified according to the French-American-British classification scheme.	9861/3 | morphology || Acute myeloid leukemia, NOS | primary_diagnosis || Not Classified | fab_morphology_code	C176985 || C177621 || C91220	morphology || primary_diagnosis || fab_morphology_code
C	C177537	GDC Value Terminology	C27780	Myelodysplastic/Myeloproliferative Neoplasm, Not Otherwise Specified	A myelodysplastic/myeloproliferative neoplasm that does not meet the criteria of other myelodysplastic/myeloproliferative neoplasms, myelodysplastic syndromes, and myeloproliferative neoplasms. It is associated with cytopenia, blasts less than 20% in bone marrow and peripheral blood, thrombocytosis, and absence of genetic abnormalities associated with myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions.	Myelodysplastic/myeloproliferative neoplasm, unclassifiable | primary_diagnosis	C177621	primary_diagnosis
C	C177537	GDC Value Terminology	C27851	Human Papillomavirus Infection	An infectious process caused by a human papillomavirus. This infection can cause abnormal tissue growth.	Human Papillomavirus Infection | comorbidities || Human Papillomavirus Infection | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C27996	Myocardial Infarction	Gross necrosis of the myocardium, as a result of interruption of the blood supply to the area, as in coronary thrombosis.	Myocardial Infarction | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C28195	Thromboembolism	Occlusion of the lumen of a vessel by a thrombus that has migrated from a distal site via the blood stream.	Deep Vein Thrombosis / Thromboembolism | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C28244	Birt-Hogg-Dube Syndrome	A rare genetic syndrome with an autosomal dominant pattern of inheritance. It is caused by a mutation in the FLCN gene which encodes the protein folliculin. Clinical signs include multiple benign growths of the skin and lungs that begin to manifest in the second or third decade of life. The clinical course is characterized by the progressive growth of new and existing neoplasms. In those with mutations in both copies of FLCN, the kidneys may also be affected by the growth of benign or malignant neoplasms.	Birt-Hogg-Dube Syndrome | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C28285	Stage IS	Testicular cancer found in the testicle, spermatic cord and scrotum, associated with slightly elevated levels of all tumor markers or moderately/highly elevated levels of one or more tumor markers.	Stage IS | ajcc_clinical_stage || Stage IS | ajcc_pathologic_stage || Stage IS | uicc_clinical_stage || Stage IS | uicc_pathologic_stage	C177555 || C177556 || C188409 || C188446	ajcc_clinical_stage || ajcc_pathologic_stage || uicc_clinical_stage || uicc_pathologic_stage
C	C177537	GDC Value Terminology	C28397	Asthma	A chronic respiratory disease manifested as difficulty breathing due to the narrowing of bronchial passageways.	Asthma | comorbidities || Asthma | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C2851	Acquired Immunodeficiency Syndrome	A syndrome resulting from the acquired deficiency of cellular immunity caused by the human immunodeficiency virus (HIV). It is characterized by the reduction of the Helper T-lymphocytes in the peripheral blood and the lymph nodes. Symptoms include generalized lymphadenopathy, fever, weight loss, and chronic diarrhea. Patients with AIDS are especially susceptible to opportunistic infections, tuberculosis, candida infections, and cryptococcosis), and the development of malignant neoplasms (usually non-Hodgkin lymphoma and Kaposi sarcoma). The human immunodeficiency virus is transmitted through sexual contact, sharing of contaminated needles, or transfusion of contaminated blood.	HIV / AIDS | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C2852	Adenocarcinoma	A common cancer characterized by the presence of malignant glandular cells.  Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreting product (e.g., mucinous, serous).  Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell carcinoma, hepatocellular carcinoma (hepatoma), colon adenocarcinoma, and prostate adenocarcinoma.	8140/3 | morphology || Adenocarcinoma | comorbidities || Adenocarcinoma, NOS | primary_diagnosis	C16457 || C176985 || C177621	comorbidities || morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C28554	Dead	The cessation of life.	Dead | vital_status || Death | first_event || Death | reason_treatment_ended || dead | vital_status	C166276 || C198107 || C25717	reason_treatment_ended || first_event || vital_status
C	C177537	GDC Value Terminology	C2869	Anemia	A reduction in the number of red blood cells, the amount of hemoglobin, and/or the volume of packed red blood cells. Clinically, anemia represents a reduction in the oxygen-transporting capacity of a designated volume of blood, resulting from an imbalance between blood loss (through hemorrhage or hemolysis) and blood production. Signs and symptoms of anemia may include pallor of the skin and mucous membranes, shortness of breath, palpitations of the heart, soft systolic murmurs, lethargy, and fatigability.	Anemia | comorbidities || Anemia | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C2881	Arrhythmia	Any variation from the normal rate or rhythm (which may include the origin of the impulse and/or its subsequent propagation) in the heart.	Arrhythmia | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C2883	Arthritis	An inflammatory process affecting a joint. Causes include infection, autoimmune processes, degenerative processes, and trauma. Signs and symptoms may include swelling around the affected joint and pain.	Arthritis | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C2884	Rheumatoid Arthritis	A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.	Rheumatoid Arthritis | comorbidities || Rheumatoid Arthritis | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C2885	Peritoneal Effusion	The accumulation of fluid in the peritoneal cavity, which may be serous, hemorrhagic, or the result of tumor metastasis to the peritoneum.	Ascites | metastasis_at_diagnosis_site || Ascites | treatment_anatomic_site	C177625 || C70729	metastasis_at_diagnosis_site || treatment_anatomic_site
C	C177537	GDC Value Terminology	C2887	Ataxia Telangiectasia Syndrome	Rare hereditary disease characterized by extreme sensitivity to ionizing radiation or radiomimetic drugs because of a defect in DNA repair. AT heterozygosity is estimated to occur in more than 2% of the U.S. population; heterozygotes exhibit increased radiation sensitivity and are at increased risk for several types of cancer. The normal version of the gene that is defective in AT appears to activate the p53-dependent response to DNA damage.	Ataxia-telangiectasia | comorbidities || Ataxia-telangiectasia | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C2891	Barrett Esophagus	Esophageal lesion lined with columnar metaplastic epithelium which is flat or villiform. Barrett epithelium is characterized by two different types of cells: goblet cells and columnar cells. The symptomatology of Barrett esophagus is that of gastro-esophageal reflux. It is the precursor of most esophageal adenocarcinomas.  (WHO)	Barrett's Esophagus | comorbidities || Barrett's Esophagus | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C2892	Nevoid Basal Cell Carcinoma Syndrome	An autosomal dominant genetic syndrome caused by abnormalities in the PTCH and SUFU gene. It is characterized by multiple basal cell carcinomas at a young age, odontogenic keratocysts, and skeletal defects (bifurcated and splayed ribs, fusion of vertebrae, spinal bifida). Patients with this syndrome may also develop medulloblastomas and ovarian fibromas.	Gorlin Syndrome | comorbidities || Gorlin Syndrome | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C2897	Benign Prostatic Hyperplasia	A non-cancerous nodular enlargement of the prostate gland.  It is characterized by the presence of epithelial cell nodules, and stromal nodules containing fibrous and smooth muscle elements.  It is the most common urologic disorder in men, causing blockage of urine flow.	Benign Prostatic Hyperplasia | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C2899	Biliary System Disorder	A non-neoplastic or neoplastic disorder that affects the intrahepatic or extrahepatic bile ducts or the gallbladder. Representative examples of non-neoplastic disorders include cholangitis and cholecystitis. Representative examples of neoplastic disorders include extrahepatic bile duct adenoma, intrahepatic and extrahepatic cholangiocarcinoma, and gallbladder carcinoma.	Biliary Disorder | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C2911	Bronchitis	An acute or chronic inflammatory process affecting the bronchi.	Bronchitis | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C2921	Skin Basal Cell Carcinoma	The most frequently seen skin cancer. It arises from basal cells of the epidermis and pilosebaceous units. Clinically it is divided into the following types: nodular, ulcerative, superficial, multicentric, erythematous, and sclerosing or morphea-like. More than 95% of these carcinomas occur in patients over 40. They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck and the remaining 15% on the trunk and extremities. Basal cell carcinoma usually grows in a slow and indolent fashion. However, if untreated, the tumor may invade the subcutaneous fat, skeletal muscle and bone. Distant metastases are rare. Excision, curettage and irradiation cure most basal cell carcinomas.	8090/3 | morphology || Basal Cell Cancer | relationship_primary_diagnosis || Basal Cell Carcinoma | comorbidities || Basal cell carcinoma, NOS | primary_diagnosis || Basal cell epithelioma | primary_diagnosis	C16457 || C176985 || C177621 || C178243	comorbidities || morphology || primary_diagnosis || relationship_primary_diagnosis
C	C177537	GDC Value Terminology	C2938	Cerebrovascular Disorder	A disorder resulting from inadequate blood flow in the vessels that supply the brain. Representative examples include cerebrovascular ischemia, cerebral embolism, and cerebral infarction.	Cerebrovascular Disease | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C2950	Cytogenetic Abnormality	An irregularity in the number or structure of chromosomes, usually in the form of a gain (duplication), loss (deletion), exchange (translocation), or alteration in sequence (inversion) of genetic material.	Structural Alteration | data_type || Structural Variation | data_category	C172272 || C175886	data_type || data_category
C	C177537	GDC Value Terminology	C2951	Cirrhosis	A disorder characterized by replacement of the liver parenchyma with fibrous tissue and regenerative nodules. It is usually caused by alcoholism, hepatitis B, and hepatitis C. Complications include the development of ascites, esophageal varices, bleeding, and hepatic encephalopathy.	Cirrhosis | additional_pathology_findings || Cirrhosis | risk_factors || Cirrhosis, Unknown Etiology | comorbidities || Liver Cirrhosis (Liver Disease) | comorbidities	C158809 || C16457 || C17103	additional_pathology_findings || comorbidities || risk_factors
C	C177537	GDC Value Terminology	C2952	Ulcerative Colitis	An inflammatory bowel disease involving the mucosal surface of the large intestine and rectum. It may present with an acute or slow onset and follows an intermittent or continuous course. Signs and symptoms include abdominal pain, diarrhea, fever, weight loss, and intestinal hemorrhage.	Ulcerative Colitis | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C2954	Colon Polyp	A polypoid lesion that arises from the colon and protrudes into the lumen.  This group includes adenomatous polyps, serrated polyps, and hamartomatous polyps.	Colon Polyps | comorbidities || Colon Polyps | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C2962	Seizure	Sudden, involuntary skeletal muscular contractions of cerebral or brain stem origin.	Seizure | comorbidities || Seizure | risk_factors || Seizures | first_symptom_prior_to_diagnosis	C157233 || C16457 || C17103	first_symptom_prior_to_diagnosis || comorbidities || risk_factors
C	C177537	GDC Value Terminology	C2965	Crohn Disease	A gastrointestinal disorder characterized by chronic inflammation involving all layers of the intestinal wall, noncaseating granulomas affecting the intestinal wall and regional lymph nodes, and transmural fibrosis. Crohn disease most commonly involves the terminal ileum; the colon is the second most common site of involvement.	Crohn's Disease | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C2978	Cyst	A sac-like closed membranous structure that may be empty or contain fluid or amorphous material.	Cyst(s) | additional_pathology_findings || Cyst(s) | risk_factors	C158809 || C17103	additional_pathology_findings || risk_factors
C	C177537	GDC Value Terminology	C2982	Depression	A melancholy feeling of sadness and despair.	Depression | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C2985	Diabetes Mellitus	A metabolic disorder characterized by abnormally high blood sugar levels due to diminished production of insulin or insulin resistance/desensitization.	Diabetes | comorbidities || Diabetes, NOS | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C2986	Type 1 Diabetes Mellitus	A chronic condition characterized by minimal or absent production of insulin by the pancreas.	Diabetes, Type I | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C3001	Eczema	A form of dermatitis characterized by red, itchy, scaly, or crusty patches that can be chronic or intermittent.	Eczema | comorbidities || Eczema | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C3014	Endometriosis	The growth of functional endometrial tissue in anatomic sites outside the uterine body. It most often occurs in the pelvic organs.	Endometriosis | additional_pathology_findings || Endometriosis | risk_factors	C158809 || C17103	additional_pathology_findings || risk_factors
C	C177537	GDC Value Terminology	C3020	Seizure Disorder	A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions.	Epilepsy | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C3037	Chronic Fatigue Syndrome	A syndrome of unknown etiology. Chronic fatigue syndrome (CFS) is a clinical diagnosis characterized by an unexplained persistent or relapsing chronic fatigue that is of at least six months' duration, is not the result of ongoing exertion, is not substantially alleviated by rest, and results in substantial reduction of previous levels of occupational, educational, social, or personal activities. Common concurrent symptoms of at least six months duration include impairment of memory or concentration, diffuse pain, sore throat, tender lymph nodes, headaches of a new type, pattern, or severity, and nonrestorative sleep. The etiology of CFS may be viral or immunologic. Neurasthenia and fibromyalgia may represent related disorders. Also known as myalgic encephalomyelitis.	Chronic Fatigue Syndrome | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C3044	Fibrosis	The formation of fibrous tissue.	Fibrosis | comorbidities || Fibrosis | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C3046	Fracture	A traumatic injury to the bone in which the continuity of the bone is broken.	Bone Fracture(s) | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C3076	Cowden Syndrome	An autosomal dominant hereditary syndrome characterized by a variety of hamartomas and neoplasms including verrucous skin lesions, fibromas of the oral cavity, facial trichilemmomas, hamartomatous colonic polyps, thyroid neoplasms, breast cancer, and dysplastic gangliocytomas of the cerebellum.	Cowden Syndrome | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C3079	Heart Disorder	A non-neoplastic or neoplastic disorder that affects the heart and/or the pericardium. Representative examples include endocarditis, pericarditis, atrial myxoma, cardiac myeloid sarcoma, and pericardial malignant mesothelioma.	Heart Disease | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C3080	Congestive Heart Failure	Failure of the heart to pump a sufficient amount of blood to meet the needs of the body tissues, resulting in tissue congestion and edema. Signs and symptoms include shortness of breath, pitting edema, enlarged tender liver, engorged neck veins, and pulmonary rales.	Congestive Heart Failure (CHF) | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C3095	Hepatitis	Inflammation of the liver; usually from a viral infection, but sometimes from toxic agents.	Hepatitis | comorbidities || Hepatitis, NOS | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C3096	Hepatitis A Infection	Acute inflammation of the liver caused by the hepatitis A virus. It is highly contagious and usually contracted through close contact with an infected individual or their feces, contaminated food or water.	Hepatitis A Infection | comorbidities || Hepatitis A Infection | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C3097	Hepatitis B Infection	A viral infection caused by the hepatitis B virus.	Hepatitis B Infection | comorbidities || Hepatitis B Infection | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C3098	Hepatitis C Infection	A viral infection caused by the hepatitis C virus.	Hepatitis C Infection | comorbidities || Hepatitis C Infection | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C3105	Von Hippel Lindau Syndrome	An inherited familial cancer syndrome which is characterized by development of capillary hemangioblastomas of the central nervous system and retina; clear cell renal carcinoma; pheochromocytoma; pancreatic tumors; and inner ear tumors. The syndrome is associated with germline mutations of the VHL tumor suppressor gene, located on chromosome 3p25-26. Symptoms of VHL syndrome may not be apparent until the third decade of life. CNS hemangioblastoma is the most common cause of death, followed by clear cell renal cell carcinoma. --2004	Von Hippel-Lindau Syndrome | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C3108	HIV Infection	An infection caused by the human immunodeficiency virus.	HIV | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C3112	Hypercalcemia	Abnormally high concentration of calcium in the peripheral blood.	Hypercalcemia | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C3117	Hypertension	Blood pressure that is abnormally high.	Hypertension | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C3132	Alpha Heavy Chain Disease	A clonal disorder, also known as immunoproliferative small intestinal disease or Mediterranean lymphoma, characterized by the secretion of a defective alpha heavy chain. It predominantly affects young people in the Mediterranean region. It involves the small intestine, and patients usually present with malabsorption syndrome, abdominal pain, weight loss, and fever. There is extensive villous atrophy of the small intestinal mucosa, which is heavily infiltrated by small lymphocytes and plasma cells. The small intestinal morphologic changes are consistent with a mucosa-associated lymphoid tissue lymphoma (MALT lymphoma).	9760/3 | morphology || 9762/3 | morphology || 9764/3 | morphology || Alpha heavy chain disease | primary_diagnosis || Immunoproliferative disease, NOS | primary_diagnosis || Immunoproliferative small intestinal disease | primary_diagnosis || Mediterranean lymphoma | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C3137	Inflammation	A finding of a localized protective response resulting from injury or destruction of tissues. Inflammation serves to destroy, dilute, or wall off both the injurious agent and the injured tissue. In the acute phase, inflammation is characterized by the signs of pain, heat, redness, swelling, and loss of function. Histologically, inflammation involves a complex series of events, including dilatation of arterioles, capillaries, and venules, with increased permeability and blood flow; exudation of fluids, including plasma proteins; and leukocyte migration into the site of inflammation.	Inflammation | additional_pathology_findings || Inflammation | risk_factors || Inflammation, Hyperkeratosis | risk_factors	C158809 || C17103	additional_pathology_findings || risk_factors
C	C177537	GDC Value Terminology	C3138	Inflammatory Bowel Disease	A spectrum of small and large bowel inflammatory diseases of unknown etiology. It includes Crohn's disease, ulcerative colitis, and colitis of indeterminate type.	Inflammatory Bowel Disease | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C3149	Kidney Disorder	A neoplastic or non-neoplastic condition affecting the kidney. Representative examples of non-neoplastic conditions include glomerulonephritis and nephrotic syndrome. Representative examples of neoplastic conditions include benign processes (e.g., renal lipoma and renal fibroma) and malignant processes (e.g., renal cell carcinoma and renal lymphoma).	Kidney Disease | comorbidities || Renal Disorder, NOS | cause_of_death	C16457 || C81239	comorbidities || cause_of_death
C	C177537	GDC Value Terminology	C3170	Acute Megakaryoblastic Leukemia	An acute myeloid leukemia in which at least 50% of the blasts are of megakaryocytic lineage. (WHO, 2001)	9910/3 | morphology || Acute megakaryoblastic leukaemia | primary_diagnosis || FAB M7 | primary_diagnosis || M7 | fab_morphology_code || Megakaryocytic leukemia | primary_diagnosis	C176985 || C177621 || C91220	morphology || primary_diagnosis || fab_morphology_code
C	C177537	GDC Value Terminology	C3174	Chronic Myeloid Leukemia, BCR-ABL1 Positive	A chronic myeloproliferative neoplasm characterized by the expression of the BCR-ABL1 fusion gene. It presents with neutrophilic leukocytosis. It can appear at any age, but it mostly affects middle aged and older individuals. Patients usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly. If untreated, it follows a biphasic or triphasic natural course; an initial indolent chronic phase which is followed by an accelerated phase, a blast phase, or both. Allogeneic stem cell transplantation and tyrosine kinase inhibitors delay disease progression and prolong overall survival.	9863/3 | morphology || 9875/3 | morphology || Chronic granulocytic leukemia, NOS | primary_diagnosis || Chronic myelocytic leukemia, NOS | primary_diagnosis || Chronic myelogenous leukemia, BCR-ABL positive | primary_diagnosis || Chronic myeloid leukemia, NOS | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C3182	Acute Promyelocytic Leukemia with t(15;17)(q24.1;q21.2); PML-RARA	An acute myeloid leukemia (AML) in which abnormal promyelocytes predominate. It is characterized by the PML-RARA fusion. There are two variants: the typical and microgranular variant.  This AML is particularly sensitive to treatment with all trans-retinoic acid and has a favorable prognosis. (WHO)	9866/3 | morphology || Acute myeloid leukemia, PML/RAR-alpha | primary_diagnosis || Acute promyelocytic leukaemia, PML-RAR-alpha | primary_diagnosis || Acute promyelocytic leukaemia, t(15;17)(q22;q11-12) | primary_diagnosis || Acute promyelocytic leukemia, NOS | primary_diagnosis || FAB M3 (includes all variants) | primary_diagnosis || M3 | fab_morphology_code	C176985 || C177621 || C91220	morphology || primary_diagnosis || fab_morphology_code
C	C177537	GDC Value Terminology	C3199	Chronic Obstructive Pulmonary Disease	A chronic and progressive lung disorder characterized by the loss of elasticity of the bronchial tree and the air sacs, destruction of the air sacs wall, thickening of the bronchial wall, and mucous accumulation in the bronchial tree. The pathologic changes result in the disruption of the air flow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough, and chest tightness. The two main types of chronic obstructive pulmonary disease are chronic obstructive bronchitis and emphysema.	COPD | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C3237	Squamous Metaplasia	A morphologic finding indicating the transformation of glandular or transitional epithelial cells to, usually, mature squamous epithelial cells.  Representative examples include squamous metaplasia of bronchial epithelium, cervix, urinary bladder, and prostate gland.	Squamous Metaplasia | risk_factors || Squamous metaplasia | additional_pathology_findings	C158809 || C17103	additional_pathology_findings || risk_factors
C	C177537	GDC Value Terminology	C3242	Multiple Myeloma	A bone marrow-based plasma cell neoplasm characterized by a serum monoclonal protein and skeletal destruction with osteolytic lesions, pathological fractures, bone pain, hypercalcemia, and anemia.  Clinical variants include non-secretory myeloma, smoldering myeloma, indolent myeloma, and plasma cell leukemia. (WHO, 2001)	9732/3 | morphology || Multiple Myeloma | relationship_primary_diagnosis || Multiple myeloma | primary_diagnosis || Myeloma, NOS | primary_diagnosis || Myelomatosis | primary_diagnosis || Plasma cell myeloma | primary_diagnosis	C176985 || C177621 || C178243	morphology || primary_diagnosis || relationship_primary_diagnosis
C	C177537	GDC Value Terminology	C3247	Myelodysplastic Syndrome	A clonal hematopoietic disorder characterized by dysplasia and ineffective hematopoiesis in one or more of the hematopoietic cell lines. The dysplasia may be accompanied by an increase in myeloblasts, but the number is less than 20%, which, according to the WHO guidelines, is the requisite threshold for the diagnosis of acute myeloid leukemia. It may occur de novo or as a result of exposure to alkylating agents and/or radiotherapy. (WHO, 2001)	9989/3 | morphology || Myelodysplastic Syndrome | risk_factors || Myelodysplastic Syndromes | disease_type || Myelodysplastic syndrome, NOS | primary_diagnosis || Preleukemia | primary_diagnosis || Preleukemic syndrome | primary_diagnosis	C17103 || C176985 || C177621 || C2991	risk_factors || morphology || primary_diagnosis || disease_type
C	C177537	GDC Value Terminology	C3249	Acute Myeloid Leukemia without Maturation	An acute myeloid leukemia (AML) characterized by blasts without evidence of maturation to more mature neutrophils. (WHO, 2001)	9873/3 | morphology || Acute myeloid leukemia without maturation | primary_diagnosis || FAB M1 | primary_diagnosis || M1 | fab_morphology_code	C176985 || C177621 || C91220	morphology || primary_diagnosis || fab_morphology_code
C	C177537	GDC Value Terminology	C3250	Acute Myeloid Leukemia with Maturation	An acute myeloid leukemia (AML) characterized by blasts with evidence of maturation to more mature neutrophils. (WHO, 2001)	9874/3 | morphology || Acute myeloid leukemia with maturation | primary_diagnosis || FAB M2, NOS | primary_diagnosis || M2 | fab_morphology_code	C176985 || C177621 || C91220	morphology || primary_diagnosis || fab_morphology_code
C	C177537	GDC Value Terminology	C32622	Foot	The structure found below the ankle joint.	Foot | biospecimen_anatomic_site || Foot | treatment_anatomic_site	C171435 || C70729	biospecimen_anatomic_site || treatment_anatomic_site
C	C177537	GDC Value Terminology	C3270	Neuroblastoma	A malignant neuroblastic tumor characterized by the presence of neuroblastic cells, the absence of ganglion cells, and the absence of a prominent Schwannian stroma formation.	9500/3 | morphology || Central neuroblastoma | primary_diagnosis || Neuroblastoma | relationship_primary_diagnosis || Neuroblastoma (NBL) | tumor_code || Neuroblastoma, NOS | primary_diagnosis	C176985 || C177615 || C177621 || C178243	morphology || tumor_code || primary_diagnosis || relationship_primary_diagnosis
C	C177537	GDC Value Terminology	C3283	Obesity	Having a high amount of body fat (body mass index [BMI] of 30 or more).	Obesity | comorbidities || Obesity | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C3293	Osteoarthritis	A noninflammatory degenerative joint disease occurring chiefly in older persons, characterised by degeneration of the articular cartilage, hypertrophy of bone at the margins and changes in the synovial membrane. It is accompanied by pain and stiffness, particularly after prolonged activity.	Osteoarthritis | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C3298	Osteoporosis	A condition of reduced bone mass, with decreased cortical thickness and a decrease in the number and size of the trabeculae of cancellous bone (but normal chemical composition), resulting in increased fracture incidence. Osteoporosis is classified as primary (Type 1, postmenopausal osteoporosis; Type 2, age-associated osteoporosis; and idiopathic, which can affect juveniles, premenopausal women, and middle-aged men) and secondary osteoporosis (which results from an identifiable cause of bone mass loss).	Osteoporosis or Osteopenia | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C3303	Pain	The sensation of discomfort, distress, or agony, resulting from the stimulation of specialized nerve endings.	Pain (Various) | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C3306	Pancreatitis	Inflammation of the pancreas.	Pancreatitis | comorbidities || Pancreatitis | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C3318	Peptic Ulcer	A mucosal erosion that occurs in the esophagus, stomach or duodenum. Symptoms can include abdominal pain, nausea and vomiting, and bleeding.	Peptic Ulcer (Ulcer) | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C3324	Peutz-Jeghers Syndrome	An inherited condition characterized by generalized hamartomatous multiple polyposis of the intestinal tract. Transmitted in an autosomal dominant fashion, Peutz-Jeghers syndrome consistently involves the jejunum and is associated with melanin spots of the lips, buccal mucosa, and fingers. This syndrome is associated with abnormalities of chromosome 19. Also known as Jeghers-Peutz syndrome and Peutz's syndrome.	Peutz-Jeghers Disease | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C333	Calcium Channel Blocker	A pharmaceutical agent that inhibits the movement of calcium across through calcium channels in the cell membrane, preventing or decreasing the amount of calcium able to enter the cell. These drugs are used for their chronotropic, antihypertensive and vasodilatory effects.	Calcium Channel Blockers | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C3331	Pleural Effusion	Increased amounts of fluid within the pleural cavity. Symptoms include shortness of breath, cough, and chest pain. It is usually caused by lung infections, congestive heart failure, pleural and lung tumors, connective tissue disorders, and trauma.	Pleural Effusion | specimen_type	C70713	specimen_type
C	C177537	GDC Value Terminology	C3334	Pneumocystis Pneumonia	Pneumonia resulting from infection with Pneumocystis jirovecii, frequently seen in the immunologically compromised, such as persons with AIDS, or steroid-treated individuals, the elderly, or premature or debilitated babies during their first three months.  Patients may be only slightly febrile (or even afebrile), but are likely to be extremely weak, dyspneic, and cyanotic. This is a major cause of morbidity among patients with AIDS.	Pneumocystis Pneumonia | aids_risk_factors || Pneumocystis Pneumonia | comorbidities || Pneumocystis Pneumonia | risk_factors	C16457 || C17103 || C177623	comorbidities || risk_factors || aids_risk_factors
C	C177537	GDC Value Terminology	C3339	Familial Adenomatous Polyposis	An autosomal dominant disorder, characterized by the presence of multiple adenomas in the colon and rectum. It is caused by a germline mutation in the adenomatous polyposis coli (APC) gene which is located on the long arm of chromosome 5. The adenomas are most often tubular, and they have the tendency to progress to adenocarcinoma. They can occur throughout the colon, but they tend to concentrate in the rectum and sigmoid colon. The colorectal adenomas are detected during endoscopic examination between the age of 10 and 20 years. The adenomas increase in size and numbers with age, and there is usually progression of one or more adenomas to adenocarcinoma. The mean age of development of adenocarcinoma is about 40 years. Signs include rectal bleeding and mucousy diarrhea.	8220/0 | morphology || Adenomatous Polyposis Coli | comorbidities || Adenomatous polyposis coli | primary_diagnosis || Familial Adenomatous Polyposis | comorbidities || Familial Adenomatous Polyposis | risk_factors || Familial polyposis coli | primary_diagnosis	C16457 || C17103 || C176985 || C177621	comorbidities || risk_factors || morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C3346	Psoriasis	An autoimmune condition characterized by red, well-delineated plaques with silvery scales that are usually on the extensor surfaces and scalp. They can occasionally present with these manifestations: pustules; erythema and scaling in intertriginous areas, and erythroderma, that are often distributed on extensor surfaces and scalp.	Psoriasis | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C3353	Acute Respiratory Distress Syndrome	Progressive and life-threatening pulmonary distress in the absence of an underlying pulmonary condition, usually following major trauma or surgery. Cases of neonatal respiratory distress syndrome are not included in this definition.	Interstitial Pneumontis or ARDS | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C3390	Stroke	A sudden loss of neurological function secondary to hemorrhage or ischemia in the brain parenchyma due to a vascular event.	Stroke | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C3423	Tuberculosis	A chronic, recurrent infection caused by the bacterium Mycobacterium tuberculosis. Tuberculosis (TB) may affect almost any tissue or organ of the body with the lungs being the most common site of infection. The clinical stages of TB are primary or initial infection, latent or dormant infection, and recrudescent or adult-type TB. Ninety to 95% of primary TB infections may go unrecognized. Histopathologically, tissue lesions consist of granulomas which usually undergo central caseation necrosis. Local symptoms of TB vary according to the part affected; acute symptoms include hectic fever, sweats, and emaciation; serious complications include granulomatous erosion of pulmonary bronchi associated with hemoptysis. If untreated, progressive TB may be associated with a high degree of mortality. This infection is frequently observed in immunocompromised individuals with AIDS or a history of illicit IV drug use.	Tuberculosis | comorbidities || Tuberculosis | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C3424	Tuberous Sclerosis	Hereditary disease characterized by seizures, mental retardation, developmental delay, and skin and ocular lesions. First signs usually occur during infancy or childhood but in rare cases may not occur until 2nd or 3rd decade.	Tuberous Sclerosis | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C34336	Spontaneous Abortion	Fetal loss at less than 20 weeks of gestation.	Miscarriage | pregnancy_outcome || Spontaneous Abortion | pregnancy_outcome	C90491	pregnancy_outcome
C	C177537	GDC Value Terminology	C34415	Beckwith-Wiedemann Syndrome	A genetic syndrome caused by abnormalities in chromosome 11. It is characterized by large birth weight, macroglossia, umbilical hernia, ear abnormalities, and hypoglycemia. Patients with this syndrome have an increased risk of developing embryonal tumors (gonadoblastoma, hepatoblastoma, Wilms tumor, rhabdomyosarcoma) and adrenal cortex carcinomas.	Beckwith-Wiedemann | comorbidities || Beckwith-Wiedemann | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C34416	Behcet Syndrome	A rare chronic inflammatory disorder of unknown etiology. It is characterized by the development of ulcers in the mouth and genital region and uveitis. Other signs and symptoms include arthritis, deep vein thrombosis and superficial thrombophlebitis.	Behcet's Disease | comorbidities || Behcet's Disease | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C3446	Primary Immune Thrombocytopenia	Acquired thrombocytopenia of unknown cause, characterized by immune-mediated destruction of normal platelets. It affects both children and adults. It manifests with petechiae, purpura, and overt bleeding. Based upon the duration of the disease, it is classified as newly diagnosed (from diagnosis until 3 months), persistent (3-12 months), and chronic (lasting for more than 12 months).	ITP | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C34463	Chlamydial Infection	An infection that is caused by Chlamydia trachomatis.	Chlamydia | comorbidities || Chlamydia | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C34594	Escherichia Coli Infection	Infection with the organism Escherichia Coli.	Escherichia coli | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C34650	Gout	A condition characterized by painful swelling of the joints, which is caused by deposition of urate crystals.	Gout | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C34661	Headache	Pain in various parts of the head, not confined to the area of distribution of any nerve.	Headache | comorbidities || Headache | risk_factors || Headaches | first_symptom_prior_to_diagnosis	C157233 || C16457 || C17103	first_symptom_prior_to_diagnosis || comorbidities || risk_factors
C	C177537	GDC Value Terminology	C34707	Hyperlipidemia	Elevated levels of lipids in the blood.	Hyperlipidemia | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C3476	Li-Fraumeni Syndrome	An autosomal dominant cancer predisposition syndrome caused by germline mutations of the TP53 gene. It is associated with breast carcinoma, choroid plexus carcinoma, adrenal cortex carcinoma, astrocytic tumors, medulloblastoma, soft tissue sarcoma, osteosarcoma, and leukemia.	Li-Fraumeni Syndrome | comorbidities || Li-Fraumeni Syndrome | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C34783	Alcoholic Liver Disease	A disorder caused by damage to the liver parenchyma due to alcohol consumption. It may present with an acute onset or follow a chronic course, leading to cirrhosis.	Alcoholic Liver Disease | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C34797	Malaria	A protozoan infection caused by the genus Plasmodium. There are four species of Plasmodium that can infect humans: Plasmodium falciparum, vivax, ovale, and malariae. It is transmitted to humans by infected mosquitoes. Signs and symptoms include paroxysmal high fever, sweating, chills, and anemia.	Malaria | comorbidities || Malaria | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C3482	Metastatic Carcinoma	Carcinoma that has spread from its original site of growth to other anatomic sites.	8010/6 | morphology || Carcinoma, metastatic, NOS | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C34995	Sarcoidosis	An idiopathic inflammatory disorder characterized by the formation of non-necrotizing epithelioid granulomas which contain giant cells. It usually affects the lungs, lymph nodes, liver, and skin. Cardiac involvement is also possible.	Sarcoidosis | comorbidities || Sarcoidosis | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C35055	Syphilis	A contagious bacterial infection caused by the spirochete Treponema pallidum. It is a sexually transmitted disorder, although it can also be transmitted from the mother to the fetus in utero. Typically, it is initially manifested with a single sore which heals without treatment. If the infection is left untreated, the initial stage is followed by skin rash and mucous membrane lesions. A late stage follows, which is characterized by damage of the internal organs, including the nervous system.	Syphilis | comorbidities || Syphilis | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C35117	Vascular Disorder	A non-neoplastic or neoplastic disorder affecting the arteries, veins, or lymphatic vessels. Examples include vasculitis, thrombophlebitis, arteriosclerosis, lymphedema, hemangioma, and angiosarcoma.	Vascular Disease | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C35136	Peripheral Vascular Disorder	Any disorder affecting blood flow through the veins or arteries outside of the heart.	Peripheral Vascular Disease | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C3519	Atypical Chronic Myeloid Leukemia	A myelodysplastic/myeloproliferative neoplasm characterized by the presence of leukocytosis with increased numbers of neutrophils, promyelocytes, myelocytes, and metamyelocytes; blasts less than 20% in bone marrow and peripheral blood; dysgranulopoiesis; minimal or absent monocytosis; absence of eosinophilia; and presence of bone marrow hypercellularity with granulocytic proliferation and granulocytic dysplasia. Dysplasia in the erythroid and megakaryocytic lineages may be present or absent. No evidence of BCR/ABL fusion is present.	9860/3 | morphology || 9876/3 | morphology || Atypical chronic myeloid leukemia, BCR/ABL negative | primary_diagnosis || Atypical chronic myeloid leukemia, Philadelphia chromosome (Ph1) negative | primary_diagnosis || Subacute granulocytic leukemia | primary_diagnosis || Subacute myelogenous leukemia | primary_diagnosis || Subacute myeloid leukemia | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C3520	Myeloid Sarcoma	A tumor mass composed of myeloblasts or immature myeloid cells.  It occurs in extramedullary sites or the bone.  (WHO, 2001)	9930/3 | morphology || Chloroma | comorbidities || Chloroma | primary_diagnosis || Chloroma | risk_factors || Myeloid sarcoma | primary_diagnosis	C16457 || C17103 || C176985 || C177621	comorbidities || risk_factors || morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C35541	Hyperkeratosis	Hypertrophy of the outermost layer of the epidermis. It may be caused by physical or chemical irritants, irradiation, infection, or neoplastic processes.	Hyperkeratosis | additional_pathology_findings || Inflammation, Hyperkeratosis | risk_factors	C158809 || C17103	additional_pathology_findings || risk_factors
C	C177537	GDC Value Terminology	C35605	Glomerular Vascular Disorder	A disorder that is caused by pathologic changes in the glomerular vasculature.	Glomerular Disease | risk_factors || Glomerular disease | additional_pathology_findings	C158809 || C17103	additional_pathology_findings || risk_factors
C	C177537	GDC Value Terminology	C36102	Hereditary Ovarian Carcinoma	Ovarian carcinoma that has developed in relatives of patients that have a history of ovarian carcinoma.	Hereditary Ovarian Cancer | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C36185	Steatosis	Acumulation of adipose tissue in intracytoplasmic or extracellular spaces.	Steatosis | comorbidities || Steatosis | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C36197	Mycobacterium Avium Infection	An infection that is caused by Mycobacterium avium.	Mycobacterium avium Complex | aids_risk_factors || Mycobacterium avium Complex | comorbidities || Mycobacterium avium Complex | risk_factors	C16457 || C17103 || C177623	comorbidities || risk_factors || aids_risk_factors
C	C177537	GDC Value Terminology	C36290	Chemical Exposure	Contact with a chemical substance through touch, inhalation, or ingestion.	Chemical | exposure_type || Chemical Exposure, NOS | chemical_exposure_type	C157103 || C198092	exposure_type || chemical_exposure_type
C	C177537	GDC Value Terminology	C3677	Benign Neoplasm	A neoplasm characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.	8000/0 | morphology || Neoplasm, benign | primary_diagnosis || Tumor, benign | primary_diagnosis || Unclassified tumor, benign | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C3693	Carcinomatosis	Carcinoma that has spread diffusely to an anatomic site or throughout the body.	8010/9 | morphology || Carcinomatosis | imaging_findings || Carcinomatosis | primary_diagnosis	C176985 || C177621 || C199145	morphology || primary_diagnosis || imaging_findings
C	C177537	GDC Value Terminology	C3718	WAGR Syndrome	A very rare congenital condition involving the complex of Wilms tumor, aniridia, genitourinary abnormalities, and mental retardation. Wilms Tumor-Aniridia-Genitourinary Anomalies-Mental Retardation (WAGR) syndrome involves deletions of several adjacent genes in chromosome region 11p13. Two or more of the four conditions must be present for an individual to be diagnosed with WAGR Syndrome. The clinical picture varies, depending upon the combination of abnormalities.	Wagr Syndrome | comorbidities || Wagr Syndrome | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C3721	Lymphomatoid Papulosis	A chronic, recurrent cutaneous disorder characterized by the presence of spontaneously regressing papules.  The papules are composed of an atypical lymphocytic infiltrate that contains anaplastic CD30-positive T-cells, which are found in type A and diffuse large cell type (type C) lymphomatoid papulosis.  In a small number of cases, of type B, the lymphocytic infiltrate is composed of small, cerebriform-like lymphocytes that are often negative for CD30.  The majority of cases follow a benign clinical course, but some cases are clonal and may progress to lymphoma.  Treatment options include low dose methotrexate and psoralen/UVA (PUVA).	9718/3 | morphology || Lymphomatoid Papulosis | comorbidities || Lymphomatoid Papulosis | risk_factors || Lymphomatoid papulosis | primary_diagnosis	C16457 || C17103 || C176985 || C177621	comorbidities || risk_factors || morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C37864	Autoimmune Lymphoproliferative Syndrome	An autoimmune hematologic disorder characterized by autoimmune hemolytic anemia, thrombocytopenia, lymphadenopathy, hepatomegaly and splenomegaly. Patients are at an increased risk of developing Hodgkin and non-Hodgkin lymphomas.	Autoimmune Lymphoproliferative Syndrome (ALPS) | comorbidities || Autoimmune Lymphoproliferative Syndrome (ALPS) | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C3790	Ganglioneuroblastoma	A malignant neuroblastic tumor characterized by the presence of neuroblastic cells, ganglion cells, and a stroma with Schwannian differentiation constituting more than fifty-percent of the tumor volume.  There are two histologic subtypes identified: ganglioneuroblastoma, intermixed and ganglioneuroblastoma, nodular.	9490/3 | morphology || Ganglioneuroblastoma | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C37967	Hypercholesterolemia	A laboratory test result indicating an increased amount of cholesterol in the blood.	Hypercholesterolemia | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C3809	Neuroendocrine Neoplasm	An epithelial neoplasm with neuroendocrine differentiation. This category includes neuroendocrine tumors, neuroendocrine carcinomas, and paragangliomas.	Neuroendocrine Tumor | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C38155	Recurrent Disease	The return of a disease after a period of remission.	Recurrence | timepoint_category || Recurrent Disease | initial_disease_status || Relapse | first_event	C177616 || C198107 || C198201	initial_disease_status || first_event || timepoint_category
C	C177537	GDC Value Terminology	C38267	Intrathecal Route of Administration	Administration of drugs directly into spinal subarachnoid space in the cerebrospinal fluid, at any level of the cerebrospinal axis, including injection into the cerebral ventricles, in order to bypass the blood-brain barrier and achieve local, rapid effects on the meninges or cerebrospinal axis.	Intrathecal | route_of_administration	C38114	route_of_administration
C	C177537	GDC Value Terminology	C38342	Pancreatic Intraductal Papillary-Mucinous Neoplasm	A usually slow-growing epithelial neoplasm with ductal differentiation that arises from the exocrine pancreas and grows mostly within the pancreatic ducts. Grossly, it is characterized by the presence of intraductal masses. Morphologically, there is proliferation of mucin-producing cells within the pancreatic ducts, intraductal accumulation of mucin, and a papillary growth pattern. It may be associated with the presence of an invasive carcinoma. It usually occurs in older patients. Signs and symptoms include epigastric pain, weight loss, jaundice, chronic pancreatitis, and diabetes mellitus.	Intraductal Papillary Mucinous Neoplasm | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C38757	Negative Finding	A finding of normality following an examination or investigation looking for the presence of a microorganism, disease, or condition.	Negative | imaging_result || Negative | peritoneal_washing_results || Negative | test_result	C176708 || C198139 || C36292	imaging_result || peritoneal_washing_results || test_result
C	C177537	GDC Value Terminology	C38758	Positive Finding	A finding of abnormality following an examination or observation confirming something, such as the presence of a disease, condition, or microorganism.	Positive | imaging_result || Positive | peritoneal_washing_results || Positive | test_result	C176708 || C198139 || C36292	imaging_result || peritoneal_washing_results || test_result
C	C177537	GDC Value Terminology	C38759	EBV Infection	An infection that is caused by Epstein-Barr virus.	Epstein-Barr Virus | comorbidities || Epstein-Barr Virus | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C38766	Lymphocytic Thyroiditis	An inflammatory disorder that affects the thyroid gland.  It is characterized by the infiltration of the thyroid parenchyma by lymphocytes.  It includes Hashimoto thyroiditis and subacute lymphocytic thyroiditis.	Lymphocytic Thyroiditis | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C389	Oral Contraceptive	An agent taken orally to prevent conception.	Oral Contraceptives | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C39291	HHV8 Infection	An infectious process caused by the human herpesvirus 8. This infection is associated with Kaposi sarcoma.	Human Herpesvirus-8 (HHV-8) | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C39293	Helicobacter Pylori Infection	A bacterial infection of the stomach, caused by Helicobacter pylori.  It is associated with the development of peptic ulcer and mucosa-associated lymphoid tissue lymphoma.	H. pylori Infection | comorbidities || H. pylori Infection | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C3938	Turcot Syndrome	An autosomal dominant hereditary neoplastic syndrome caused by mutations in the PMS2, MLH1, MSH2, or APC genes. There are two types described, type 1, characterized by the presence of glioblastoma and often associated with hereditary nonpolyposis colorectal carcinoma, and type 2, characterized by the presence of medulloblastoma and familiar adenomatous polyposis.	Turcot Syndrome | comorbidities || Turcot Syndrome | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C3954	Gastric Polyp	A polyp that arises from the stomach.  This category includes neoplastic polyps (intestinal-type adenomatous polyps, gastric-type adenomas, and fundic gland polyps), and non-neoplastic polyps (hyperplastic polyps and hamartomatous polyps).	Gastric Polyp(s) | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C39594	Skin Rash	Any change in the skin which affects its appearance or texture. A rash may be localized to one part of the body, or affect all the skin. Rashes may cause the skin to change color, itch, become warm, bumpy, dry, cracked or blistered, swell and may be painful.	Skin Rash | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C39789	Hereditary Renal Cell Carcinoma	Renal cell carcinoma that has developed in relatives of patients with history of renal cell carcinoma.	Hereditary Renal Cell Carcinoma | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C40341	Hypospadias	A congenital abnormality in which the external urethral orifice is on the underside of the penis. In a minority of cases it is associated with other genitourinary abnormalities.	Hypospadias | comorbidities || Hypospadias | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C41067	Whole Blood	Blood that has not been separated into its various components; blood that has not been modified except for the addition of an anticoagulant.	Peripheral Whole Blood | specimen_type	C70713	specimen_type
C	C177537	GDC Value Terminology	C41132	None	No person or thing, nobody, not any.	No Treatment | reflux_treatment_type || None | first_event || None | immunosuppressive_treatment_type || None | lymph_node_involved_site || None | risk_factors	C17103 || C177637 || C198107 || C33027 || C574	risk_factors || reflux_treatment_type || first_event || lymph_node_involved_site || immunosuppressive_treatment_type
C	C177537	GDC Value Terminology	C42046	Undifferentiated Neuroblastoma	A neuroblastoma characterized by the absence of differentiating neuroblasts.	Undifferentiated | inpc_grade || Undifferentiated or Poorly Differentiated | inpc_grade	C102562	inpc_grade
C	C177537	GDC Value Terminology	C42047	Poorly Differentiated Neuroblastoma	A neuroblastoma in which the differentiating neuroblasts constitute less than five-percent of the tumor cells.	Poorly Differentiated | inpc_grade || Undifferentiated or Poorly Differentiated | inpc_grade	C102562	inpc_grade
C	C177537	GDC Value Terminology	C4242	Benign Soft Tissue Neoplasm	A neoplasm that arises from soft tissue and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.	8800/0 | morphology || Soft tissue tumor, benign | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C43234	Not Reported	Not provided or available.	Not Reported | adapter_content || Not Reported | adrenal_hormone || Not Reported | ajcc_clinical_m || Not Reported | ajcc_clinical_n || Not Reported | ajcc_clinical_stage || Not Reported | ajcc_clinical_t || Not Reported | ajcc_pathologic_m || Not Reported | ajcc_pathologic_n || Not Reported | ajcc_pathologic_stage || Not Reported | ajcc_pathologic_t || Not Reported | ajcc_staging_system_edition || Not Reported | alcohol_history || Not Reported | alcohol_intensity || Not Reported | alcohol_type || Not Reported | anaplasia_present || Not Reported | anaplasia_present_type || Not Reported | ann_arbor_b_symptoms || Not Reported | ann_arbor_clinical_stage || Not Reported | ann_arbor_extranodal_involvement || Not Reported | ann_arbor_pathologic_stage || Not Reported | antigen || Not Reported | barretts_esophagus_goblet_cells_present || Not Reported | basic_statistics || Not Reported | biospecimen_anatomic_site || Not Reported | biospecimen_laterality || Not Reported | biospecimen_type || Not Reported | bone_marrow_malignant_cells || Not Reported | burkitt_lymphoma_clinical_variant || Not Reported | cancer_detection_method || Not Reported | cause_of_death || Not Reported | cause_of_death_source || Not Reported | cdc_hiv_risk_factors || Not Reported | chemical_exposure_type || Not Reported | chemo_concurrent_to_radiation || Not Reported | child_pugh_classification || Not Reported | chromosomal_Not Reported | chromosome || Not Reported | chromosome_arm || Not Reported | clinical_trial_indicator || Not Reported | cog_liver_stage || Not Reported | cog_neuroblastoma_risk_group || Not Reported | cog_renal_stage || Not Reported | cog_rhabdomyosarcoma_risk_group || Not Reported | columnar_mucosa_present || Not Reported | comorbidities || Not Reported | comorbidity_method_of_diagnosis || Not Reported | consistent_pathology_review || Not Reported | diabetes_treatment_type || Not Reported | diagnosis_pathologically_confirmed || Not Reported | disease_response || Not Reported | disease_type || Not Reported | distance_normal_to_tumor || Not Reported | double_expressor_lymphoma || Not Reported | double_hit_lymphoma || Not Reported | dysplasia_degree || Not Reported | dysplasia_type || Not Reported | ecog_performance_status || Not Reported | eln_risk_classification || Not Reported | enneking_msts_grade || Not Reported | enneking_msts_metastasis || Not Reported | enneking_msts_stage || Not Reported | enneking_msts_tumor_site || Not Reported | esophageal_columnar_dysplasia_degree || Not Reported | esophageal_columnar_metaplasia_present || Not Reported | exposure_duration || Not Reported | extracapsular_extension || Not Reported | eye_color || Not Reported | figo_stage || Not Reported | first_event || Not Reported | first_symptom_prior_to_diagnosis || Not Reported | gastric_esophageal_junction_involvement || Not Reported | gene_symbol || Not Reported | gleason_grade_group || Not Reported | goblet_cells_columnar_mucosa_present || Not Reported | haart_treatment_indicator || Not Reported | hepatitis_sustained_virological_response || Not Reported | histone_family || Not Reported | histone_variant || Not Reported | history_of_tumor || Not Reported | hormonal_contraceptive_type || Not Reported | hormonal_contraceptive_use || Not Reported | hormone_replacement_therapy_type || Not Reported | hysterectomy_margins_involved || Not Reported | hysterectomy_type || Not Reported | igcccg_stage || Not Reported | imaging_findings || Not Reported | imaging_result || Not Reported | immunosuppressive_treatment_type || Not Reported | initial_disease_status || Not Reported | inpc_grade || Not Reported | inpc_histologic_group || Not Reported | inrg_stage || Not Reported | inss_stage || Not Reported | instrument_model || Not Reported | irs_group || Not Reported | irs_stage || Not Reported | ishak_fibrosis_score || Not Reported | iss_stage || Not Reported | karnofsky_performance_status || Not Reported | kmer_content || Not Reported | laboratory_test || Not Reported | largest_extrapelvic_peritoneal_focus || Not Reported | laterality || Not Reported | lymph_node_involved_site || Not Reported | lymph_node_involvement || Not Reported | lymph_nodes_removed || Not Reported | lymphatic_invasion_present || Not Reported | margin_status || Not Reported | medulloblastoma_molecular_classification || Not Reported | menopause_status || Not Reported | metaplasia_present || Not Reported | metastasis_at_diagnosis || Not Reported | metastasis_at_diagnosis_site || Not Reported | method_of_diagnosis || Not Reported | method_of_sample_procurement || Not Reported | micropapillary_features || Not Reported | mismatch_repair_mutation || Not Reported | mitosis_karyorrhexis_index || Not Reported | molecular_analysis_method || Not Reported | morphology || Not Reported | necrosis_present || Not Reported | non_nodal_regional_disease || Not Reported | non_nodal_tumor_deposits || Not Reported | normal_tumor_genotype_snp_match || Not Reported | ovarian_specimen_status || Not Reported | ovarian_surface_involvement || Not Reported | overrepresented_sequences || Not Reported | parent_with_radiation_exposure || Not Reported | per_base_n_content || Not Reported | per_base_sequence_content || Not Reported | per_base_sequence_quality || Not Reported | per_sequence_gc_content || Not Reported | per_sequence_quality_score || Not Reported | per_tile_sequence_quality || Not Reported | perineural_invasion_present || Not Reported | peripancreatic_lymph_nodes_positive || Not Reported | peritoneal_fluid_cytological_status || Not Reported | peritoneal_washing_results || Not Reported | ploidy || Not Reported | pregnancy_outcome || Not Reported | pregnant_at_diagnosis || Not Reported | premature_at_birth || Not Reported | preservation_method || Not Reported | primary_diagnosis || Not Reported | primary_site || Not Reported | prior_treatment || Not Reported | procedures_performed || Not Reported | progression_or_recurrence || Not Reported | progression_or_recurrence_anatomic_site || Not Reported | progression_or_recurrence_type || Not Reported | reflux_treatment_type || Not Reported | relationship_primary_diagnosis || Not Reported | relationship_type || Not Reported | residual_disease || Not Reported | rhabdoid_present || Not Reported | risk_factor_method_of_diagnosis || Not Reported | risk_factor_treatment || Not Reported | risk_factors || Not Reported | route_of_administration || Not Reported | sarcomatoid_present || Not Reported | satellite_nodule_present || Not Reported | second_gene_symbol || Not Reported | secondhand_smoke_as_child || Not Reported | sequence_duplication_levels || Not Reported | sequence_length_distribution || Not Reported | site_of_resection_or_biopsy || Not Reported | sites_of_involvement || Not Reported | specimen_type || Not Reported | supratentorial_localization || Not Reported | synchronous_malignancy || Not Reported | test_analyte_type || Not Reported | test_result || Not Reported | test_units || Not Reported | therapeutic_agents || Not Reported | timepoint_category || Not Reported | tissue_or_organ_of_origin || Not Reported | tissue_type || Not Reported | tobacco_smoking_status || Not Reported | transglottic_extension || Not Reported | treatment_anatomic_site || Not Reported | treatment_effect || Not Reported | treatment_effect_indicator || Not Reported | treatment_frequency || Not Reported | treatment_intent_type || Not Reported | treatment_outcome || Not Reported | treatment_type || Not Reported | tumor_confined_to_organ_of_origin || Not Reported | tumor_descriptor || Not Reported | tumor_focality || Not Reported | tumor_grade || Not Reported | tumor_grade_category || Not Reported | tumor_regression_grade || Not Reported | uicc_clinical_m || Not Reported | uicc_clinical_n || Not Reported | uicc_clinical_stage || Not Reported | uicc_clinical_t || Not Reported | uicc_pathologic_m || Not Reported | uicc_pathologic_n || Not Reported | uicc_pathologic_stage || Not Reported | uicc_pathologic_t || Not Reported | uicc_staging_system_edition || Not Reported | undescended_testis_corrected || Not Reported | undescended_testis_corrected_laterality || Not Reported | undescended_testis_corrected_method || Not Reported | undescended_testis_history || Not Reported | undescended_testis_history_laterality || Not Reported | variant_type || Not Reported | vascular_invasion_present || Not Reported | vascular_invasion_type || Not Reported | viral_hepatitis_serologies || Not Reported | vital_status || Not Reported | weiss_assessment_findings || Not Reported | who_cns_grade || Not Reported | who_nte_grade || Not Reported | wilms_tumor_histologic_subtype || Not Reported | zygosity || not reported | classification_of_tumor || not reported | ethnicity || not reported | gender || not reported | last_known_disease_status || not reported | prior_malignancy || not reported | progression_or_recurrence || not reported | race || not reported | relationship_gender || not reported | relative_with_cancer_history || not reported | treatment_or_therapy || not reported | vital_status	C102562 || C104015 || C105721 || C106304 || C106317 || C106541 || C111073 || C112400 || C121007 || C123560 || C125738 || C125904 || C126378 || C127768 || C127772 || C129439 || C13202 || C133427 || C13355 || C133706 || C138899 || C139007 || C140258 || C140259 || C140262 || C140266 || C141342 || C142346 || C15256 || C15599 || C156421 || C156422 || C157233 || C157410 || C157425 || C157437 || C158874 || C159643 || C160720 || C160827 || C160996 || C16124 || C161320 || C16165 || C162221 || C16457 || C16564 || C166229 || C16687 || C17001 || C17049 || C17103 || C171253 || C171435 || C173263 || C173544 || C17357 || C173595 || C174459 || C175524 || C176287 || C176708 || C176985 || C177549 || C177550 || C177555 || C177556 || C177557 || C177558 || C177559 || C177561 || C177562 || C177564 || C177565 || C177566 || C177567 || C177568 || C177570 || C177571 || C177572 || C177576 || C177578 || C177585 || C177586 || C177587 || C177588 || C177589 || C177590 || C177591 || C177592 || C177593 || C177594 || C177595 || C177596 || C177597 || C177598 || C177599 || C177600 || C177601 || C177602 || C177603 || C177605 || C177606 || C177607 || C177608 || C177609 || C177610 || C177611 || C177612 || C177616 || C177617 || C177619 || C177620 || C177621 || C177622 || C177624 || C177625 || C177626 || C177630 || C177631 || C177632 || C177633 || C177634 || C177635 || C177636 || C177637 || C177638 || C177640 || C177641 || C178243 || C178276 || C178286 || C178287 || C178288 || C178289 || C181720 || C181723 || C182060 || C182097 || C182099 || C182101 || C182102 || C182109 || C185264 || C185265 || C185266 || C185267 || C185268 || C185269 || C185270 || C185271 || C185272 || C185273 || C185274 || C185275 || C188387 || C188406 || C188408 || C188409 || C188411 || C188415 || C188429 || C188446 || C188448 || C18849 || C18919 || C1909 || C19232 || C19697 || C19770 || C19796 || C198091 || C198092 || C198101 || C198107 || C198139 || C198195 || C198201 || C198204 || C198206 || C199145 || C25185 || C25218 || C25294 || C25717 || C268 || C28013 || C28076 || C29878 || C2991 || C33027 || C3420 || C35529 || C36037 || C36292 || C38032 || C38114 || C39694 || C4086 || C45824 || C45902 || C4809 || C49236 || C50995 || C54398 || C574 || C67415 || C70700 || C70713 || C70729 || C81229 || C81239 || C83280 || C83315 || C83393 || C85416 || C89081 || C90491 || C92808 || C93431 || C95149 || C99532	inpc_grade || weiss_assessment_findings || ecog_performance_status || tumor_regression_grade || mitosis_karyorrhexis_index || menopause_status || igcccg_stage || premature_at_birth || child_pugh_classification || margin_status || figo_stage || double_hit_lymphoma || alcohol_intensity || perineural_invasion_present || vascular_invasion_present || medulloblastoma_molecular_classification || chromosome || inrg_stage || chromosome_arm || mismatch_repair_mutation || double_expressor_lymphoma || iss_stage || enneking_msts_stage || enneking_msts_grade || enneking_msts_tumor_site || enneking_msts_metastasis || chemo_concurrent_to_radiation || gleason_grade_group || hysterectomy_type || hormone_replacement_therapy_type || site_of_resection_or_biopsy || tissue_or_organ_of_origin || first_symptom_prior_to_diagnosis || hormonal_contraceptive_use || tumor_focality || eye_color || primary_site || lymph_nodes_removed || lymphatic_invasion_present || satellite_nodule_present || transglottic_extension || prior_treatment || synchronous_malignancy || haart_treatment_indicator || metastasis_at_diagnosis || comorbidities || ethnicity || tumor_descriptor || histone_family || ploidy || race || risk_factors || second_gene_symbol || biospecimen_anatomic_site || sites_of_involvement || variant_type || gender || gene_symbol || classification_of_tumor || peritoneal_fluid_cytological_status || cause_of_death_source || imaging_result || morphology || irs_group || irs_stage || ajcc_clinical_stage || ajcc_pathologic_stage || test_analyte_type || ann_arbor_clinical_stage || ann_arbor_pathologic_stage || ajcc_staging_system_edition || eln_risk_classification || comorbidity_method_of_diagnosis || inpc_histologic_group || who_cns_grade || who_nte_grade || wilms_tumor_histologic_subtype || progression_or_recurrence_anatomic_site || supratentorial_localization || distance_normal_to_tumor || method_of_diagnosis || dysplasia_degree || ann_arbor_b_symptoms || ann_arbor_extranodal_involvement || bone_marrow_malignant_cells || burkitt_lymphoma_clinical_variant || columnar_mucosa_present || diagnosis_pathologically_confirmed || esophageal_columnar_metaplasia_present || gastric_esophageal_junction_involvement || barretts_esophagus_goblet_cells_present || goblet_cells_columnar_mucosa_present || hysterectomy_margins_involved || metaplasia_present || necrosis_present || non_nodal_regional_disease || non_nodal_tumor_deposits || normal_tumor_genotype_snp_match || ovarian_surface_involvement || progression_or_recurrence || rhabdoid_present || risk_factor_treatment || biospecimen_laterality || ajcc_clinical_m || ajcc_pathologic_m || ovarian_specimen_status || viral_hepatitis_serologies || instrument_model || ajcc_clinical_n || ajcc_pathologic_n || initial_disease_status || last_known_disease_status || pregnant_at_diagnosis || histone_variant || primary_diagnosis || relationship_gender || cdc_hiv_risk_factors || metastasis_at_diagnosis_site || secondhand_smoke_as_child || cog_liver_stage || cog_neuroblastoma_risk_group || cog_renal_stage || cog_rhabdomyosarcoma_risk_group || hepatitis_sustained_virological_response || ajcc_clinical_t || ajcc_pathologic_t || reflux_treatment_type || treatment_effect_indicator || progression_or_recurrence_type || esophageal_columnar_dysplasia_degree || relationship_primary_diagnosis || peripancreatic_lymph_nodes_positive || anaplasia_present || anaplasia_present_type || vascular_invasion_type || largest_extrapelvic_peritoneal_focus || consistent_pathology_review || undescended_testis_corrected_laterality || parent_with_radiation_exposure || undescended_testis_corrected || undescended_testis_history || undescended_testis_corrected_method || undescended_testis_history_laterality || adrenal_hormone || adapter_content || basic_statistics || kmer_content || overrepresented_sequences || per_base_n_content || per_base_sequence_content || per_base_sequence_quality || per_sequence_gc_content || per_sequence_quality_score || per_tile_sequence_quality || sequence_duplication_levels || sequence_length_distribution || clinical_trial_indicator || uicc_clinical_m || uicc_clinical_n || uicc_clinical_stage || uicc_clinical_t || uicc_pathologic_m || uicc_pathologic_n || uicc_pathologic_stage || uicc_pathologic_t || history_of_tumor || prior_malignancy || treatment_outcome || therapeutic_agents || preservation_method || tissue_type || molecular_analysis_method || tobacco_smoking_status || cancer_detection_method || chemical_exposure_type || extracapsular_extension || first_event || peritoneal_washing_results || risk_factor_method_of_diagnosis || timepoint_category || tumor_grade_category || uicc_staging_system_edition || imaging_findings || laterality || treatment_type || laboratory_test || vital_status || antigen || karnofsky_performance_status || tumor_grade || relative_with_cancer_history || disease_type || lymph_node_involved_site || chromosomal_lymph_node_involvement || tumor_confined_to_organ_of_origin || test_result || treatment_effect || route_of_administration || sarcomatoid_present || dysplasia_type || zygosity || alcohol_type || residual_disease || treatment_or_therapy || disease_response || treatment_intent_type || immunosuppressive_treatment_type || test_units || method_of_sample_procurement || specimen_type || treatment_anatomic_site || alcohol_history || cause_of_death || exposure_duration || biospecimen_type || relationship_type || inss_stage || treatment_frequency || pregnancy_outcome || hormonal_contraceptive_type || procedures_performed || ishak_fibrosis_score || diabetes_treatment_type
C	C177537	GDC Value Terminology	C4337	Mantle Cell Lymphoma	A non-Hodgkin lymphoma composed of small to medium sized B-lymphocytes (centrocytes). Most patients present with advanced stage disease with lymphadenopathy, hepatosplenomegaly, and bone marrow involvement. The gastrointestinal tract is the most commonly affected extranodal site by this type of non-Hodgkin lymphoma. The vast majority of cases express the t(11;14)(q13;q32) resulting in the rearrangement of the BCL-1 gene and the overexpression of cyclin D1 mRNA.	9673/3 | morphology || Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | primary_diagnosis || Mantle cell lymphoma (Includes all variants blastic, pleomorphic, small cell) | primary_diagnosis || Mantle zone lymphoma | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C4345	Myeloproliferative Neoplasm	A group of myeloid neoplasms that includes the following: chronic myeloid leukemia, BCR-ABL1 positive; polycythemia vera; essential thrombocythemia;  primary myelofibrosis; chronic neutrophilic leukemia; chronic eosinophilic leukemia, not otherwise specified; and myeloproliferative neoplasm, unclassifiable.	9960/3 | morphology || Chronic Myeloproliferative Disorders | disease_type || Chronic myeloproliferative disease, NOS | primary_diagnosis || Chronic myeloproliferative disorder | primary_diagnosis || Myeloproliferative disease, NOS | primary_diagnosis || Myeloproliferative neoplasm, NOS | primary_diagnosis	C176985 || C177621 || C2991	morphology || primary_diagnosis || disease_type
C	C177537	GDC Value Terminology	C43627	Sarcomatoid Hepatocellular Carcinoma	A morphologic variant of hepatocellular carcinoma characterized by the presence of malignant spindle cells or atypical giant cells.	8173/3 | morphology || Hepatocellular carcinoma, sarcomatoid | primary_diagnosis || Hepatocellular carcinoma, spindle cell variant | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C4376	Renal Failure	An acute or chronic condition that is characterized by the inability of the kidneys to adequately filter the blood.	Renal Insufficiency | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C449	DNA	A long linear double-stranded polymer formed from nucleotides attached to a deoxyribose backbone and found in the nucleus of a cell; associated with the transmission of genetic information.	DNA | analyte_type || DNA | test_analyte_type	C156434 || C177557	analyte_type || test_analyte_type
C	C177537	GDC Value Terminology	C4503	Hereditary Breast Carcinoma	Breast carcinoma that has developed in relatives of patients with history of breast carcinoma.	Hereditary Breast Cancer | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C4615	Benign Skin Appendage Neoplasm	A neoplasm that arises from the hair follicles, sebaceous glands, or sweat glands. It is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include cylindroma, hidrocystoma, hidradenoma, and sebaceoma.	8400/3 | morphology || Skin appendage tumor, benign | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C4665	Plasma Cell Neoplasm	A clonal proliferation of immunoglobulin-secreting plasma cells. This category includes multiple myeloma, plasma cell leukemia, plasmacytoma, and plasma cell post-transplant lymphoproliferative disorder.	9731/3 | morphology || Plasma Cell Tumors | disease_type || Plasma cell tumor | primary_diagnosis	C176985 || C177621 || C2991	morphology || primary_diagnosis || disease_type
C	C177537	GDC Value Terminology	C4798	Recurrent Neoplasm	The reemergence of a neoplasm after a period of remission.	Recurrence | tumor_descriptor || recurrence | classification_of_tumor	C166229 || C174459	tumor_descriptor || classification_of_tumor
C	C177537	GDC Value Terminology	C4828	Primary Sclerosing Cholangitis	A chronic, autoimmune inflammatory liver disorder characterized by narrowing and scarring of the lumen of the bile ducts. It is often seen in patients with ulcerative colitis. Signs and symptoms include jaundice, fatigue, and malabsorption. It may lead to cirrhosis and liver failure.	Primary Sclerosing Cholangitis | comorbidities || Primary Sclerosing Cholangitis | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C4861	Acute Monocytic Leukemia	An acute myeloid leukemia in which the majority of monocytic cells are promonocytes.  (WHO, 2001)	9860/3 | morphology || 9891/3 | morphology || Acute monocytic leukemia | primary_diagnosis || Monocytic leukemia, NOS | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C48658	Indeterminate	Cannot distinguish between two or more possible values in the current context.	Indeterminant | lymph_node_involvement || Indeterminant | margin_status || Indeterminant | method_of_sample_procurement || Indeterminate | imaging_result || Indeterminate | non_nodal_regional_disease || Indeterminate | ovarian_surface_involvement || Indeterminate | satellite_nodule_present	C123560 || C160827 || C176708 || C177597 || C177600 || C35529 || C70700	margin_status || satellite_nodule_present || imaging_result || non_nodal_regional_disease || ovarian_surface_involvement || lymph_node_involvement || method_of_sample_procurement
C	C177537	GDC Value Terminology	C48699	M0 TNM Finding	A distant metastasis TNM finding indicating that there is no evidence of distant metastasis.	M0 | ajcc_clinical_m || M0 | ajcc_pathologic_m || M0 | uicc_clinical_m || M0 | uicc_pathologic_m	C177606 || C177607 || C188406 || C188415	ajcc_clinical_m || ajcc_pathologic_m || uicc_clinical_m || uicc_pathologic_m
C	C177537	GDC Value Terminology	C48700	M1 TNM Finding	A clinical and/or pathologic distant metastasis TNM finding indicating the spread of cancer to distant anatomic sites.	M1 | ajcc_clinical_m || M1 | ajcc_pathologic_m || M1 | uicc_clinical_m || M1 | uicc_pathologic_m	C177606 || C177607 || C188406 || C188415	ajcc_clinical_m || ajcc_pathologic_m || uicc_clinical_m || uicc_pathologic_m
C	C177537	GDC Value Terminology	C48701	M1a TNM Finding	A TNM finding indicating the spread of cancer to distant anatomic sites.  The definition of M1a TNM finding depends on the specific type of cancer that it refers to; for example, for colorectal cancer it refers to metastasis confined to one organ or site (e.g., liver, lung, ovary, nonregional node); for prostate cancer it refers to metastasis to non-regional lymph node(s); for bone cancer it refers to metastasis to the lung.	M1a | ajcc_clinical_m || M1a | ajcc_pathologic_m || M1a | uicc_clinical_m || M1a | uicc_pathologic_m	C177606 || C177607 || C188406 || C188415	ajcc_clinical_m || ajcc_pathologic_m || uicc_clinical_m || uicc_pathologic_m
C	C177537	GDC Value Terminology	C48702	M1b TNM Finding	A TNM finding indicating the spread of cancer to distant anatomic sites.  The definition of M1b TNM finding depends on the specific type of cancer that it refers to; for example, for colorectal cancer it refers to metastases in more than one organ/site or the peritoneum; for prostate cancer it refers to metastasis to bone(s); for bone cancer it refers to metastasis to distant sites other than lung.	M1b | ajcc_clinical_m || M1b | ajcc_pathologic_m || M1b | uicc_clinical_m || M1b | uicc_pathologic_m	C177606 || C177607 || C188406 || C188415	ajcc_clinical_m || ajcc_pathologic_m || uicc_clinical_m || uicc_pathologic_m
C	C177537	GDC Value Terminology	C48703	M1c TNM Finding	A TNM finding indicating the spread of cancer to distant anatomic sites.  The definition of M1c TNM finding depends on the specific type of cancer that it refers to; for example, for prostate cancer it refers to metastasis to anatomic site(s) other than bone, with or without bone disease; for retinoblastoma it refers to central nervous system metastasis; for melanoma of the uvea it refers to distant metastasis, with the largest diameter of the largest metastasis measuring 8.0 cm or more.	M1c | ajcc_clinical_m || M1c | ajcc_pathologic_m || M1c | uicc_clinical_m || M1c | uicc_pathologic_m	C177606 || C177607 || C188406 || C188415	ajcc_clinical_m || ajcc_pathologic_m || uicc_clinical_m || uicc_pathologic_m
C	C177537	GDC Value Terminology	C48704	MX TNM Finding	A distant metastasis TNM finding indicating that the status of distant metastasis cannot be assessed.	MX | ajcc_clinical_m || MX | ajcc_pathologic_m || MX | uicc_clinical_m || MX | uicc_pathologic_m	C177606 || C177607 || C188406 || C188415	ajcc_clinical_m || ajcc_pathologic_m || uicc_clinical_m || uicc_pathologic_m
C	C177537	GDC Value Terminology	C48705	N0 TNM Finding	A regional lymph node TNM finding indicating that there is no evidence of regional lymph node metastasis.	N0 | ajcc_clinical_n || N0 | ajcc_pathologic_n || N0 | uicc_clinical_n || N0 | uicc_pathologic_n	C177611 || C177612 || C188408 || C188429	ajcc_clinical_n || ajcc_pathologic_n || uicc_clinical_n || uicc_pathologic_n
C	C177537	GDC Value Terminology	C48706	N1 TNM Finding	A general term that refers to a TNM finding of cancer metastases usually in a limited number of regional lymph nodes. The definition of N1 TNM finding depends on the specific type of cancer that it refers to; for example, for breast cancer it refers to micrometastases or metastases in 1-3 axillary lymph nodes; for cutaneous melanoma it refers to metastasis in 1 regional lymph node; for colorectal cancer it refers to metastases in 1-3 regional lymph nodes; and for bladder cancer it refers to metastasis in 1 regional lymph node in the true pelvis.	N1 | ajcc_clinical_n || N1 | ajcc_pathologic_n || N1 | uicc_clinical_n || N1 | uicc_pathologic_n	C177611 || C177612 || C188408 || C188429	ajcc_clinical_n || ajcc_pathologic_n || uicc_clinical_n || uicc_pathologic_n
C	C177537	GDC Value Terminology	C48707	N1a TNM Finding	A general term that refers to a TNM finding of cancer metastases usually in a limited number of regional lymph nodes. The definition of N1a TNM finding depends on the specific type of cancer that it refers to; for example, for breast cancer it refers to metastasis in 1 to 3 axillary lymph nodes (at least 1 tumor deposit greater than 2.0 mm); for cutaneous melanoma it refers to micrometastasis in one regional lymph node; for colorectal cancer it refers to metastasis in one regional lymph node.	N1a | ajcc_clinical_n || N1a | ajcc_pathologic_n || N1a | uicc_clinical_n || N1a | uicc_pathologic_n	C177611 || C177612 || C188408 || C188429	ajcc_clinical_n || ajcc_pathologic_n || uicc_clinical_n || uicc_pathologic_n
C	C177537	GDC Value Terminology	C48708	N1b TNM Finding	A general term that refers to a TNM finding of cancer metastases usually in a limited number of regional lymph nodes. The definition of N1b TNM finding depends on the specific type of cancer that it refers to; for example, for breast cancer it refers to metastases in internal mammary lymph nodes with micrometastases or macrometastases detected by sentinel lymph node biopsy but not clinically detected; for cutaneous melanoma it refers to macrometastasis in one regional lymph node; for colorectal cancer it refers to metastasis in 2-3 regional lymph nodes.	N1b | ajcc_clinical_n || N1b | ajcc_pathologic_n || N1b | uicc_clinical_n || N1b | uicc_pathologic_n	C177611 || C177612 || C188408 || C188429	ajcc_clinical_n || ajcc_pathologic_n || uicc_clinical_n || uicc_pathologic_n
C	C177537	GDC Value Terminology	C48709	N1c TNM Finding	A general term that refers to a TNM finding of cancer metastases usually in a limited number of regional lymph nodes. The definition of N1c TNM finding depends on the specific type of cancer that it refers to; for example, for breast cancer it refers to metastases in 1 to 3 axillary lymph nodes and in internal mammary lymph nodes with micrometastases or macrometastases detected by sentinel lymph node biopsy but not clinically detected; for colorectal cancer it refers to tumor deposit(s) in the subserosa, mesentery, or nonperitonealized pericolic or perirectal tissues without regional lymph node metastasis.	N1c | ajcc_clinical_n || N1c | ajcc_pathologic_n || N1c | uicc_clinical_n || N1c | uicc_pathologic_n	C177611 || C177612 || C188408 || C188429	ajcc_clinical_n || ajcc_pathologic_n || uicc_clinical_n || uicc_pathologic_n
C	C177537	GDC Value Terminology	C48711	N2a TNM Finding	A general term that refers to a TNM finding of cancer metastases in several regional lymph nodes.  The definition of N2a TNM finding depends on the specific type of cancer that it refers to; for example, for breast cancer it refers to metastases in 4 to 9 axillary lymph nodes (at least 1 tumor deposit greater than 2.0 mm); for cutaneous melanoma it refers to micrometastases in 2-3 regional lymph nodes; for colorectal cancer it refers to metastases in 4-6 regional lymph nodes.	N2a | ajcc_clinical_n || N2a | ajcc_pathologic_n || N2a | uicc_clinical_n || N2a | uicc_pathologic_n	C177611 || C177612 || C188408 || C188429	ajcc_clinical_n || ajcc_pathologic_n || uicc_clinical_n || uicc_pathologic_n
C	C177537	GDC Value Terminology	C48712	N2b TNM Finding	A general term that refers to a TNM finding of cancer metastases in several regional lymph nodes.  The definition of N2b TNM finding depends on the specific type of cancer that it refers to; for example, for breast cancer it refers to metastases only in clinically detected ipsilateral internal mammary nodes and in the absence of clinically evident level I, II axillary lymph node metastases; for cutaneous melanoma it refers to macrometastases in 2-3 regional lymph nodes; for colorectal cancer it refers to metastases in seven or more regional lymph nodes.	N2b | ajcc_clinical_n || N2b | ajcc_pathologic_n || N2b | uicc_clinical_n || N2b | uicc_pathologic_n	C177611 || C177612 || C188408 || C188429	ajcc_clinical_n || ajcc_pathologic_n || uicc_clinical_n || uicc_pathologic_n
C	C177537	GDC Value Terminology	C48713	N2c TNM Finding	A general term that refers to a TNM finding of cancer metastases in several regional lymph nodes.  The definition of N2c TNM finding depends on the specific type of cancer that it refers to; for example, for cutaneous melanoma it refers to intralymphatic metastases (in transit or satellite metastases) without metastatic nodes; for lip and oral cavity cancer it refers to metastases in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.	N2c | ajcc_clinical_n || N2c | ajcc_pathologic_n || N2c | uicc_clinical_n || N2c | uicc_pathologic_n	C177611 || C177612 || C188408 || C188429	ajcc_clinical_n || ajcc_pathologic_n || uicc_clinical_n || uicc_pathologic_n
C	C177537	GDC Value Terminology	C48714	N3 TNM Finding	A general term that refers to a TNM finding of cancer metastases in multiple lymph nodes. The definition of N3 TNM finding depends on the specific type of cancer that it refers to; for example, for breast cancer it refers to metastases in 10 or more axillary lymph nodes; for cutaneous melanoma it refers to metastases in 4 or more regional lymph nodes; for gastric cancer it refers to metastases in 7 or more regional lymph nodes; and for bladder cancer it refers to metastases in common iliac lymph nodes.	N3 | ajcc_clinical_n || N3 | ajcc_pathologic_n || N3 | uicc_clinical_n || N3 | uicc_pathologic_n	C177611 || C177612 || C188408 || C188429	ajcc_clinical_n || ajcc_pathologic_n || uicc_clinical_n || uicc_pathologic_n
C	C177537	GDC Value Terminology	C48715	N3a TNM Finding	A general term that refers to a TNM finding of cancer metastases in multiple lymph nodes.  The definition of N3a TNM finding depends on the specific type of cancer that it refers to; for example, for breast cancer it refers to metastases in 10 or more axillary lymph nodes (at least one tumor deposit greater than 2.0 mm) or metastases to the infraclavicular (level III axillary) lymph nodes; for gastric cancer it refers to metastases in 7-15 regional lymph nodes; for nasopharyngeal cancer it refers to metastases to one or more lymph nodes greater than 6 cm in greatest dimension.	N3a | ajcc_clinical_n || N3a | ajcc_pathologic_n || N3a | uicc_clinical_n || N3a | uicc_pathologic_n	C177611 || C177612 || C188408 || C188429	ajcc_clinical_n || ajcc_pathologic_n || uicc_clinical_n || uicc_pathologic_n
C	C177537	GDC Value Terminology	C48716	N3b TNM Finding	A general term that refers to a TNM finding of cancer metastases in multiple lymph nodes.  The definition of N3b TNM finding depends on the specific type of cancer that it refers to; for example, for breast cancer it refers to metastases in clinically detected ipsilateral internal mammary lymph nodes in the presence of one or more positive axillary lymph nodes, or in more than 3 axillary lymph nodes and in internal mammary lymph nodes with micrometastases or macrometastases detected by sentinel lymph node biopsy but not clinically detected; for gastric cancer it refers to metastases in sixteen or more regional lymph nodes; for nasopharyngeal cancer it refers to extension to the supraclavicular fossa.	N3b | ajcc_clinical_n || N3b | ajcc_pathologic_n || N3b | uicc_clinical_n || N3b | uicc_pathologic_n	C177611 || C177612 || C188408 || C188429	ajcc_clinical_n || ajcc_pathologic_n || uicc_clinical_n || uicc_pathologic_n
C	C177537	GDC Value Terminology	C48717	N3c TNM Finding	A general term that refers to a TNM finding of cancer metastases in multiple lymph nodes.  The definition of N3c TNM finding depends on the specific type of cancer that it refers to; for example, for breast cancer it refers to metastases in ipsilateral supraclavicular lymph nodes.	N3c | ajcc_clinical_n || N3c | ajcc_pathologic_n || N3c | uicc_clinical_n || N3c | uicc_pathologic_n	C177611 || C177612 || C188408 || C188429	ajcc_clinical_n || ajcc_pathologic_n || uicc_clinical_n || uicc_pathologic_n
C	C177537	GDC Value Terminology	C48718	NX TNM Finding	A regional lymph node TNM finding indicating that the status of regional lymph nodes cannot be assessed.	NX | ajcc_clinical_n || NX | ajcc_pathologic_n || NX | uicc_clinical_n || NX | uicc_pathologic_n	C177611 || C177612 || C188408 || C188429	ajcc_clinical_n || ajcc_pathologic_n || uicc_clinical_n || uicc_pathologic_n
C	C177537	GDC Value Terminology	C48719	T0 TNM Finding	A primary tumor TNM finding indicating that there is no evidence of primary tumor.	T0 | ajcc_clinical_t || T0 | ajcc_pathologic_t || T0 | uicc_clinical_t || T0 | uicc_pathologic_t	C177635 || C177636 || C188411 || C188448	ajcc_clinical_t || ajcc_pathologic_t || uicc_clinical_t || uicc_pathologic_t
C	C177537	GDC Value Terminology	C48720	T1 TNM Finding	A clinical and/or pathologic primary tumor TNM finding indicating that the cancer is limited to the site of growth.	T1 | ajcc_clinical_t || T1 | ajcc_pathologic_t || T1 | uicc_clinical_t || T1 | uicc_pathologic_t	C177635 || C177636 || C188411 || C188448	ajcc_clinical_t || ajcc_pathologic_t || uicc_clinical_t || uicc_pathologic_t
C	C177537	GDC Value Terminology	C48721	T1a TNM Finding	A general term that refers to a TNM finding of a primary tumor limited to the site of growth.  The definition of T1a TNM finding depends on the specific type of cancer that it refers to; for example, for breast cancer it refers to a primary tumor that is more than 0.1cm, but not more than 0.5 cm in greatest dimension; for kidney cancer it refers to a primary tumor that is 4 cm or less in greatest dimension; and for thyroid cancer it refers to a primary tumor that is 1 cm or less in greatest dimension.	T1a | ajcc_clinical_t || T1a | ajcc_pathologic_t || T1a | uicc_clinical_t || T1a | uicc_pathologic_t	C177635 || C177636 || C188411 || C188448	ajcc_clinical_t || ajcc_pathologic_t || uicc_clinical_t || uicc_pathologic_t
C	C177537	GDC Value Terminology	C48722	T1b TNM Finding	A general term that refers to a TNM finding of a primary tumor limited to the site of growth.  The definition of T1b TNM finding depends on the specific type of cancer that it refers to; for example, for breast cancer it refers to a primary tumor that is more than 0.5 cm, but not more than 1.0 cm in greatest dimension; for kidney cancer it refers to a primary tumor that is more than 4 cm, but not more than 7 cm in greatest dimension; and for thyroid cancer it refers to a primary tumor that is more than 1 cm but not more than 2 cm in greatest dimension.	T1b | ajcc_clinical_t || T1b | ajcc_pathologic_t || T1b | uicc_clinical_t || T1b | uicc_pathologic_t	C177635 || C177636 || C188411 || C188448	ajcc_clinical_t || ajcc_pathologic_t || uicc_clinical_t || uicc_pathologic_t
C	C177537	GDC Value Terminology	C48723	T1c TNM Finding	A general term that refers to a TNM finding of a primary tumor limited to the site of growth.  The definition of T1c TNM finding depends on the specific type of cancer that it refers to; for example, for breast cancer it refers to a primary tumor that is more than 1.0 cm, but not more than 2.0 cm in greatest dimension; for uterine corpus cancer it refers to a primary tumor that invades one-half or more of the myometrium; and for melanoma of the iris it refers to a primary tumor limited to the iris with secondary glaucoma.	T1c | ajcc_clinical_t || T1c | ajcc_pathologic_t || T1c | uicc_clinical_t || T1c | uicc_pathologic_t	C177635 || C177636 || C188411 || C188448	ajcc_clinical_t || ajcc_pathologic_t || uicc_clinical_t || uicc_pathologic_t
C	C177537	GDC Value Terminology	C48724	T2 TNM Finding	A general term that refers to a TNM finding of primary tumor growth beyond the level of in situ cancer, minimal subepithelial invasion, or minimal greatest diameter. The definition of T2 TNM finding depends on the specific type of cancer that it refers to; for example, for breast cancer it refers to primary tumor that is more than 2.0 cm, but not more than 5.0 cm in greatest dimension; for cutaneous melanoma it refers to primary tumor that is 1.01 to 2 mm in thickness, with or without ulceration; for colorectal cancer it refers to primary tumor with invasion into the muscularis propria; and for bladder cancer it refers to primary tumor with invasion into the muscle layer.	T2 | ajcc_clinical_t || T2 | ajcc_pathologic_t || T2 | uicc_clinical_t || T2 | uicc_pathologic_t	C177635 || C177636 || C188411 || C188448	ajcc_clinical_t || ajcc_pathologic_t || uicc_clinical_t || uicc_pathologic_t
C	C177537	GDC Value Terminology	C48725	T2a TNM Finding	A general term that refers to a TNM finding of a primary tumor growth beyond the level of in situ cancer, minimal subepithelial invasion, or minimal greatest diameter. The definition of T2a TNM finding depends on the specific type of cancer that it refers to; for example, for kidney cancer it refers to a primary tumor that measures more than 7 cm but less than or equal to 10 cm in greatest dimension, and is limited to the kidney; for bladder cancer it refers to a primary tumor that invades the superficial muscularis propria (inner half); for cervical cancer it refers to a primary tumor that invades beyond the uterus but not to the pelvic wall or to the lower third of vagina and there is no parametrial invasion.	T2a | ajcc_clinical_t || T2a | ajcc_pathologic_t || T2a | uicc_clinical_t || T2a | uicc_pathologic_t	C177635 || C177636 || C188411 || C188448	ajcc_clinical_t || ajcc_pathologic_t || uicc_clinical_t || uicc_pathologic_t
C	C177537	GDC Value Terminology	C48726	T2b TNM Finding	A general term that refers to a TNM finding of a primary tumor growth beyond the level of in situ cancer, minimal subepithelial invasion, or minimal greatest diameter. The definition of T2b TNM finding depends on the specific type of cancer that it refers to; for example, for kidney cancer it refers to a primary tumor that measures more than 10 cm in greatest dimension, and is limited to the kidney; for bladder cancer it refers to a primary tumor that invades the deep muscularis propria (outer half); for cervical cancer it refers to a primary tumor that invades beyond the uterus but not to the pelvic wall or to the lower third of vagina and there is parametrial invasion.	T2b | ajcc_clinical_t || T2b | ajcc_pathologic_t || T2b | uicc_clinical_t || T2b | uicc_pathologic_t	C177635 || C177636 || C188411 || C188448	ajcc_clinical_t || ajcc_pathologic_t || uicc_clinical_t || uicc_pathologic_t
C	C177537	GDC Value Terminology	C48727	T2c TNM Finding	A general term that refers to a TNM finding of a primary tumor growth beyond the level of in situ cancer, minimal subepithelial invasion, or minimal greatest diameter. The definition of T2c TNM finding depends on the specific type of cancer that it refers to; for example, for prostate cancer it refers to a primary tumor that involves both lobes of the prostate gland; for ovarian cancer it refers to a primary tumor that involves one or both ovaries with extension or implants on the uterus and/or fallopian tubes, or other pelvic tissues, with malignant cells in either ascites or peritoneal washings; for fallopian tube cancer it refers to a primary tumor with pelvic extension and malignant cells in ascites or peritoneal washings.	T2c | ajcc_clinical_t || T2c | ajcc_pathologic_t || T2c | uicc_clinical_t || T2c | uicc_pathologic_t	C177635 || C177636 || C188411 || C188448	ajcc_clinical_t || ajcc_pathologic_t || uicc_clinical_t || uicc_pathologic_t
C	C177537	GDC Value Terminology	C48728	T3 TNM Finding	A clinical and/or pathologic primary tumor TNM finding usually indicating that the cancer is locally invasive, without infiltration of adjacent structures.	T3 | ajcc_clinical_t || T3 | ajcc_pathologic_t || T3 | uicc_clinical_t || T3 | uicc_pathologic_t	C177635 || C177636 || C188411 || C188448	ajcc_clinical_t || ajcc_pathologic_t || uicc_clinical_t || uicc_pathologic_t
C	C177537	GDC Value Terminology	C48729	T3a TNM Finding	A general term that refers to a TNM finding of a primary tumor usually indicating that the cancer is locally invasive. The definition of T3a TNM finding depends on the specific type of cancer that it refers to; for example, for kidney cancer it refers to a primary tumor that grossly extends into the renal vein or its segmental (muscle containing) branches or the tumor invades perirenal and/or renal sinus fat but does not extends beyond Gerota's fascia; for cervical cancer it refers to a primary tumor that involves the lower third of vagina, without extension to pelvic wall; for liver cancer it refers to the presence of multiple tumors measuring more than 5 cm in greatest dimension.	T3a | ajcc_clinical_t || T3a | ajcc_pathologic_t || T3a | uicc_clinical_t || T3a | uicc_pathologic_t	C177635 || C177636 || C188411 || C188448	ajcc_clinical_t || ajcc_pathologic_t || uicc_clinical_t || uicc_pathologic_t
C	C177537	GDC Value Terminology	C48730	T3b TNM Finding	A general term that refers to a TNM finding of a primary tumor usually indicating that the cancer is locally invasive. The definition of T3b TNM finding depends on the specific type of cancer that it refers to; for example, for kidney cancer it refers to a primary tumor that grossly extends into the vena cava below the diaphragm; for cervical cancer it refers to a primary tumor that extends to the pelvic wall and/or causes hydronephrosis or nonfunctioning kidney; for liver cancer it refers to a single tumor or multiple tumors of any size involving a major branch of the portal vein or hepatic vein.	T3b | ajcc_clinical_t || T3b | ajcc_pathologic_t || T3b | uicc_clinical_t || T3b | uicc_pathologic_t	C177635 || C177636 || C188411 || C188448	ajcc_clinical_t || ajcc_pathologic_t || uicc_clinical_t || uicc_pathologic_t
C	C177537	GDC Value Terminology	C48731	T3c TNM Finding	A general term that refers to a TNM finding of a primary tumor usually indicating that the cancer is locally invasive. The definition of T3c TNM finding depends on the specific type of cancer that it refers to; for example, for kidney cancer it refers to a primary tumor that grossly extends into the vena cava above the diaphragm, or invades the wall of the vena cava; for fallopian tube cancer it refers to a primary tumor with peritoneal metastasis outside the pelvis measuring more than 2 cm in diameter; for melanoma of the conjunctiva it refers to a primary tumor invading the orbit.	T3c | ajcc_clinical_t || T3c | ajcc_pathologic_t || T3c | uicc_clinical_t || T3c | uicc_pathologic_t	C177635 || C177636 || C188411 || C188448	ajcc_clinical_t || ajcc_pathologic_t || uicc_clinical_t || uicc_pathologic_t
C	C177537	GDC Value Terminology	C48732	T4 TNM Finding	A clinical and/or pathologic primary tumor TNM finding indicating direct invasion of adjacent structures by cancer.	T4 | ajcc_clinical_t || T4 | ajcc_pathologic_t || T4 | uicc_clinical_t || T4 | uicc_pathologic_t	C177635 || C177636 || C188411 || C188448	ajcc_clinical_t || ajcc_pathologic_t || uicc_clinical_t || uicc_pathologic_t
C	C177537	GDC Value Terminology	C48733	T4a TNM Finding	A general term that refers to a TNM finding of a primary tumor with direct invasion of adjacent structures. The definition of T4a TNM finding depends on the specific type of cancer that it refers to; for example, for bladder cancer it refers to a primary tumor that invades the prostatic stroma, uterus, and vagina; for gastric cancer it refers to a primary tumor that invades the serosa (visceral peritoneum); for colorectal cancer it refers to a primary tumor that penetrates to the surface of the visceral peritoneum.	T4a | ajcc_clinical_t || T4a | ajcc_pathologic_t || T4a | uicc_clinical_t || T4a | uicc_pathologic_t	C177635 || C177636 || C188411 || C188448	ajcc_clinical_t || ajcc_pathologic_t || uicc_clinical_t || uicc_pathologic_t
C	C177537	GDC Value Terminology	C48734	T4b TNM Finding	A general term that refers to a TNM finding of a primary tumor with direct invasion of adjacent structures. The definition of T4b TNM finding depends on the specific type of cancer that it refers to; for example, for bladder cancer it refers to a primary tumor that invades the pelvic wall and abdominal wall; for gastric cancer it refers to a primary tumor that invades adjacent structures; for colorectal cancer it refers to a primary tumor with direct invasion or adherence to other organs or structures.	T4b | ajcc_clinical_t || T4b | ajcc_pathologic_t || T4b | uicc_clinical_t || T4b | uicc_pathologic_t	C177635 || C177636 || C188411 || C188448	ajcc_clinical_t || ajcc_pathologic_t || uicc_clinical_t || uicc_pathologic_t
C	C177537	GDC Value Terminology	C48735	T4c TNM Finding	A general term that refers to a TNM finding of a primary tumor with direct invasion of adjacent structures. The definition of T4c TNM finding depends on the specific type of cancer that it refers to; for example, for breast cancer it refers to a primary tumor that extends to the chest wall, not including the pectoralis muscle, and with edema (including peau d'orange) or ulceration of the skin of the breast or satellite skin nodules confined to the same breast; for ocular adnexal lymphoma it refers to a primary tumor that Involves the maxillofacial, ethmoidal, and/or frontal sinuses; for carcinoma of the conjunctiva it refers to a primary tumor that invades adjacent paranasal sinuses.	T4c | ajcc_clinical_t || T4c | ajcc_pathologic_t || T4c | uicc_clinical_t || T4c | uicc_pathologic_t	C177635 || C177636 || C188411 || C188448	ajcc_clinical_t || ajcc_pathologic_t || uicc_clinical_t || uicc_pathologic_t
C	C177537	GDC Value Terminology	C48736	T4d TNM Finding	A general term that refers to a TNM finding of a primary tumor with direct invasion of adjacent structures. The definition of T4d TNM finding depends on the specific type of cancer that it refers to; for example, for breast cancer it refers to a primary tumor that meets the clinical-pathologic criteria of inflammatory carcinoma; for ocular adnexal lymphoma it refers to a primary tumor with intracranial spread; for carcinoma of the conjunctiva it refers to a primary tumor that invades the brain.	T4d | ajcc_clinical_t || T4d | ajcc_pathologic_t || T4d | uicc_clinical_t || T4d | uicc_pathologic_t	C177635 || C177636 || C188411 || C188448	ajcc_clinical_t || ajcc_pathologic_t || uicc_clinical_t || uicc_pathologic_t
C	C177537	GDC Value Terminology	C48737	TX TNM Finding	A primary tumor TNM finding indicating that the status of the primary tumor cannot be assessed.	TX | ajcc_clinical_t || TX | ajcc_pathologic_t || TX | uicc_clinical_t || TX | uicc_pathologic_t	C177635 || C177636 || C188411 || C188448	ajcc_clinical_t || ajcc_pathologic_t || uicc_clinical_t || uicc_pathologic_t
C	C177537	GDC Value Terminology	C48738	Tis TNM Finding	A term that refers to a TNM finding of a primary tumor microscopically defined as carcinoma in situ.	Stage Tis | ajcc_clinical_stage || Stage Tis | ajcc_pathologic_stage || Stage Tis | uicc_clinical_stage || Stage Tis | uicc_pathologic_stage || Tis | ajcc_clinical_t || Tis | ajcc_pathologic_t || Tis | uicc_clinical_t || Tis | uicc_pathologic_t	C177555 || C177556 || C177635 || C177636 || C188409 || C188411 || C188446 || C188448	ajcc_clinical_stage || ajcc_pathologic_stage || ajcc_clinical_t || ajcc_pathologic_t || uicc_clinical_stage || uicc_clinical_t || uicc_pathologic_stage || uicc_pathologic_t
C	C177537	GDC Value Terminology	C48786	N2 TNM Finding	A general term that refers to a TNM finding of cancer metastases in several regional lymph nodes. The definition of N2 TNM finding depends on the specific type of cancer that it refers to; for example, for breast cancer it refers to metastases in 4-9 axillary lymph nodes; for cutaneous melanoma it refers to metastases in 2-3 regional lymph nodes; for colorectal cancer it refers to metastases in 4 or more regional lymph nodes; and for bladder cancer it refers to metastases in multiple regional lymph nodes in the true pelvis.	N2 | ajcc_clinical_n || N2 | ajcc_pathologic_n || N2 | uicc_clinical_n || N2 | uicc_pathologic_n	C177611 || C177612 || C188408 || C188429	ajcc_clinical_n || ajcc_pathologic_n || uicc_clinical_n || uicc_pathologic_n
C	C177537	GDC Value Terminology	C4879	Benign Sweat Gland Neoplasm	An epithelial neoplasm that arises from the sweat gland and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.	8400/0 | morphology || Sweat gland tumor, benign | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C4882	Benign Muscle Neoplasm	A mesenchymal neoplasm that arises from smooth, skeletal, or cardiac muscle and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.	8895/0 | morphology || Myoma | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C49142	Copy Number	The number of molecules of a particular type on or in a cell or part of a cell. Usually applied to specific genes or to plasmids within a bacterium.	Copy Number Reported | test_result	C36292	test_result
C	C177537	GDC Value Terminology	C49343	Deep Vein Thrombosis	A blood clot in a deep vein, predominantly in the lower extremity, but may include the pelvis or upper extremity.	DVT/PE | comorbidities || Deep Vein Thrombosis / Thromboembolism | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C49487	No	The non-affirmative response to a question.	No | adrenal_hormone || No | alcohol_history || No | anaplasia_present || No | ann_arbor_b_symptoms || No | ann_arbor_extranodal_involvement || No | barretts_esophagus_goblet_cells_present || No | bone_marrow_malignant_cells || No | chemo_concurrent_to_radiation || No | clinical_trial_indicator || No | columnar_mucosa_present || No | consistent_pathology_review || No | diagnosis_pathologically_confirmed || No | double_expressor_lymphoma || No | double_hit_lymphoma || No | environmental_tobacco_smoke_exposure || No | esophageal_columnar_metaplasia_present || No | gastric_esophageal_junction_involvement || No | goblet_cells_columnar_mucosa_present || No | haart_treatment_indicator || No | hepatitis_sustained_virological_response || No | history_of_tumor || No | lost_to_followup || No | lymph_nodes_removed || No | lymphatic_invasion_present || No | metaplasia_present || No | mismatch_repair_mutation || No | necrosis_present || No | non_nodal_tumor_deposits || No | normal_tumor_genotype_snp_match || No | parent_with_radiation_exposure || No | perineural_invasion_present || No | pregnant_at_diagnosis || No | premature_at_birth || No | prior_treatment || No | progression_or_recurrence || No | rhabdoid_present || No | risk_factor_treatment || No | sarcomatoid_present || No | secondhand_smoke_as_child || No | synchronous_malignancy || No | treatment_effect_indicator || No | tumor_confined_to_organ_of_origin || No | undescended_testis_corrected || No | undescended_testis_history || No | vascular_invasion_present || no | prior_malignancy || no | progression_or_recurrence || no | relative_with_cancer_history || no | treatment_or_therapy	C112400 || C125904 || C127768 || C127772 || C133706 || C138899 || C141342 || C159643 || C159824 || C160720 || C16124 || C161320 || C16165 || C17140 || C177585 || C177586 || C177587 || C177589 || C177590 || C177591 || C177592 || C177593 || C177595 || C177596 || C177598 || C177599 || C177601 || C177602 || C177603 || C177619 || C177626 || C177634 || C177638 || C178286 || C181720 || C182060 || C182097 || C182099 || C182109 || C188387 || C18849 || C29878 || C36037 || C39694 || C49236 || C81229	premature_at_birth || double_hit_lymphoma || perineural_invasion_present || vascular_invasion_present || mismatch_repair_mutation || double_expressor_lymphoma || chemo_concurrent_to_radiation || lymph_nodes_removed || lost_to_followup || lymphatic_invasion_present || prior_treatment || synchronous_malignancy || haart_treatment_indicator || environmental_tobacco_smoke_exposure || ann_arbor_b_symptoms || ann_arbor_extranodal_involvement || bone_marrow_malignant_cells || columnar_mucosa_present || diagnosis_pathologically_confirmed || esophageal_columnar_metaplasia_present || gastric_esophageal_junction_involvement || barretts_esophagus_goblet_cells_present || goblet_cells_columnar_mucosa_present || metaplasia_present || necrosis_present || non_nodal_tumor_deposits || normal_tumor_genotype_snp_match || progression_or_recurrence || rhabdoid_present || risk_factor_treatment || pregnant_at_diagnosis || secondhand_smoke_as_child || hepatitis_sustained_virological_response || treatment_effect_indicator || anaplasia_present || consistent_pathology_review || parent_with_radiation_exposure || undescended_testis_corrected || undescended_testis_history || adrenal_hormone || clinical_trial_indicator || history_of_tumor || prior_malignancy || relative_with_cancer_history || tumor_confined_to_organ_of_origin || sarcomatoid_present || treatment_or_therapy || alcohol_history
C	C177537	GDC Value Terminology	C49488	Yes	The affirmative response to a question.	Yes | adrenal_hormone || Yes | alcohol_history || Yes | anaplasia_present || Yes | ann_arbor_b_symptoms || Yes | ann_arbor_extranodal_involvement || Yes | barretts_esophagus_goblet_cells_present || Yes | bone_marrow_malignant_cells || Yes | chemo_concurrent_to_radiation || Yes | clinical_trial_indicator || Yes | columnar_mucosa_present || Yes | consistent_pathology_review || Yes | diagnosis_pathologically_confirmed || Yes | double_expressor_lymphoma || Yes | double_hit_lymphoma || Yes | environmental_tobacco_smoke_exposure || Yes | esophageal_columnar_metaplasia_present || Yes | gastric_esophageal_junction_involvement || Yes | goblet_cells_columnar_mucosa_present || Yes | haart_treatment_indicator || Yes | hepatitis_sustained_virological_response || Yes | history_of_tumor || Yes | lost_to_followup || Yes | lymph_nodes_removed || Yes | lymphatic_invasion_present || Yes | metaplasia_present || Yes | mismatch_repair_mutation || Yes | necrosis_present || Yes | non_nodal_tumor_deposits || Yes | normal_tumor_genotype_snp_match || Yes | parent_with_radiation_exposure || Yes | perineural_invasion_present || Yes | pregnant_at_diagnosis || Yes | premature_at_birth || Yes | prior_treatment || Yes | progression_or_recurrence || Yes | rhabdoid_present || Yes | risk_factor_treatment || Yes | sarcomatoid_present || Yes | secondhand_smoke_as_child || Yes | synchronous_malignancy || Yes | treatment_effect_indicator || Yes | tumor_confined_to_organ_of_origin || Yes | undescended_testis_corrected || Yes | undescended_testis_history || Yes | vascular_invasion_present || yes | prior_malignancy || yes | progression_or_recurrence || yes | relative_with_cancer_history || yes | treatment_or_therapy	C112400 || C125904 || C127768 || C127772 || C133706 || C138899 || C141342 || C159643 || C159824 || C160720 || C16124 || C161320 || C16165 || C17140 || C177585 || C177586 || C177587 || C177589 || C177590 || C177591 || C177592 || C177593 || C177595 || C177596 || C177598 || C177599 || C177601 || C177602 || C177603 || C177619 || C177626 || C177634 || C177638 || C178286 || C181720 || C182060 || C182097 || C182099 || C182109 || C188387 || C18849 || C29878 || C36037 || C39694 || C49236 || C81229	premature_at_birth || double_hit_lymphoma || perineural_invasion_present || vascular_invasion_present || mismatch_repair_mutation || double_expressor_lymphoma || chemo_concurrent_to_radiation || lymph_nodes_removed || lost_to_followup || lymphatic_invasion_present || prior_treatment || synchronous_malignancy || haart_treatment_indicator || environmental_tobacco_smoke_exposure || ann_arbor_b_symptoms || ann_arbor_extranodal_involvement || bone_marrow_malignant_cells || columnar_mucosa_present || diagnosis_pathologically_confirmed || esophageal_columnar_metaplasia_present || gastric_esophageal_junction_involvement || barretts_esophagus_goblet_cells_present || goblet_cells_columnar_mucosa_present || metaplasia_present || necrosis_present || non_nodal_tumor_deposits || normal_tumor_genotype_snp_match || progression_or_recurrence || rhabdoid_present || risk_factor_treatment || pregnant_at_diagnosis || secondhand_smoke_as_child || hepatitis_sustained_virological_response || treatment_effect_indicator || anaplasia_present || consistent_pathology_review || parent_with_radiation_exposure || undescended_testis_corrected || undescended_testis_history || adrenal_hormone || clinical_trial_indicator || history_of_tumor || prior_malignancy || relative_with_cancer_history || tumor_confined_to_organ_of_origin || sarcomatoid_present || treatment_or_therapy || alcohol_history
C	C177537	GDC Value Terminology	C50466	Atrial Fibrillation	A disorder characterized by an electrocardiographic finding of a supraventricular arrhythmia characterized by the replacement of consistent P waves by rapid oscillations or fibrillatory waves that vary in size, shape and timing and are accompanied by an irregular ventricular response. (CDISC)	Atrial Fibrillation | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C50625	Ischemic Heart Disease	A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries, to obstruction by a thrombus, or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (myocardial infarction).	Ischemic Heart Disease | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C50713	Pulmonary Embolism	The obstruction of the pulmonary artery or one of its branches by an embolus, sometimes associated with infarction of the lung.	DVT/PE | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C50781	Transient Ischemic Attack	A brief attack (from a few minutes to an hour) of cerebral dysfunction of vascular origin, with no persistent neurological deficit.	Transient Ischemic Attack | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C50791	Urinary Tract Infection	A bacterial infectious process affecting any part of the urinary tract, most commonly the bladder and the urethra. Symptoms include urinary urgency and frequency, burning sensation during urination, lower abdominal discomfort, and cloudy urine.	Urinary Tract Infection | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C50910	Osteopenia	Decreased calcification or density of bone tissue.	Osteoporosis or Osteopenia | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C51302	Hereditary Leiomyomatosis and Renal Cell Carcinoma	An autosomal dominant inherited syndrome caused by germline mutations in the FH gene. It is characterized by predisposition to renal cell carcinoma, leiomyomas of the skin and uterus, and leiomyosarcoma of the uterus.	Hereditary Leiomyomatosis and Renal Cell Carcinoma | risk_factors || Hereditary leiomyomatosis & RCC-associated renal cell carcinoma | primary_diagnosis	C17103 || C177621	risk_factors || primary_diagnosis
C	C177537	GDC Value Terminology	C52810	Sciatic Nerve	The long nerve that is formed by the merging of the ventral rami of the L4, L5, and S1 in the pelvis and passes down the lower limb where it divides into the common peroneal and tibial nerves.	Sciatic Nerve | biospecimen_anatomic_site || Sciatic Nerve | treatment_anatomic_site	C171435 || C70729	biospecimen_anatomic_site || treatment_anatomic_site
C	C177537	GDC Value Terminology	C53649	Cytomegaloviral Infection	A herpesvirus infection caused by Cytomegalovirus. Healthy individuals generally do not produce symptoms. However, the infection may be life-threatening in affected immunocompromised patients. The virus may cause retinitis, esophagitis, gastritis, and colitis. Morphologically, it is characterized by the presence of intranuclear inclusion bodies.	Cytomegalovirus | aids_risk_factors || Cytomegalovirus (CMV) | comorbidities || Cytomegalovirus (CMV) | risk_factors	C16457 || C17103 || C177623	comorbidities || risk_factors || aids_risk_factors
C	C177537	GDC Value Terminology	C5541	High Grade Prostatic Intraepithelial Neoplasia	Prostatic intraepithelial neoplasia characterized by the presence of morphologically malignant cells lining the acini and ducts.  The malignant cells are enlarged, contain prominent nucleoli, and have increased nuclear/cytoplasmic ratio.  The malignant cells may grow within the ducts and acini in four architectural patterns: flat, tufting, micropapillary, and cribriform.  The presence of high grade prostatic intraepithelial neoplasia in needle biopsy is a risk factor for the subsequent detection of carcinoma on repeat biopsy.	High-grade Prostatic Intraepithelial Neoplasia (PIN) | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C55816	Asbestos Exposure	Inhalation of asbestos fibers.	Asbestos | chemical_exposure_type || Asbestos | exposure_type	C157103 || C198092	exposure_type || chemical_exposure_type
C	C177537	GDC Value Terminology	C5665	Atypical Adenomatous Lung Hyperplasia	A preinvasive lesion in the lung. It is characterized by the presence of a small, localized proliferation of mildly to moderately atypical type II pneumocytes and/or Clara cells lining alveolar walls and sometimes respiratory bronchioles.	Adenosis (Atypical Adenomatous Hyperplasia) | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C60989	Myasthenia Gravis	A chronic autoimmune neuromuscular disorder characterized by skeletal muscle weakness. It is caused by the blockage of the acetylcholine receptors at the neuromuscular junction.	Myasthenia Gravis | comorbidities || Myasthenia Gravis | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C612	Recombinant Luteinizing Hormone	Any recombinant form of the endogenously produced heterodimer glycoprotein luteinizing hormone (LH) normally made by the anterior pituitary gland, that can be used for the treatment of LH deficiency. Upon administration, recombinant LH mimics the biological activity of endogenous LH. In females, this triggers ovulation and the development of the corpus luteum. In males, LH stimulates Leydig cells to produce testosterone.	Recombinant Luteinizing Hormone | therapeutic_agents	C1909	therapeutic_agents
C	C177537	GDC Value Terminology	C61272	Glycogen Storage Disease	An inherited metabolic disorder characterized either by defects in glycogen synthesis or defects in the breaking down of glycogen. It results either in the creation of abnormal forms of glycogen or accumulation of glycogen in the tissues.	Glycogen Storage Disease | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C62505	Fanconi Anemia	An autosomal recessive genetic disorder characterized by bone marrow failure, skeletal abnormalities, and an increased incidence of the development of neoplasias.	Fanconi Anemia | comorbidities || Fanconi Anemia | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C62586	Cryptogenic Organizing Pneumonia	A form of organizing pneumonia with a non-infectious etiology. Excessive proliferation of granulation tissue occurs in alveolar ducts and alveoli and primarily causes injury to alveolar walls, but bronchioles may be affected.	Cryptogenic Organizing Pneumonia | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C65108	Never Smoker	A person who has never smoked at the time of the interview or has smoked less than 100 cigarettes in their life.	Lifelong Non-Smoker | tobacco_smoking_status	C19796	tobacco_smoking_status
C	C177537	GDC Value Terminology	C65157	Neoplasm, Uncertain Whether Benign or Malignant	A neoplasm which, on morphologic grounds, can not be classified with certainty as benign or malignant.	8000/1 | morphology || Neoplasm, uncertain whether benign or malignant | primary_diagnosis || Unclassified tumor, borderline malignancy | primary_diagnosis || Unclassified tumor, uncertain whether benign or malignant | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C67147	Current Smoker	An adult who has smoked 100 cigarettes in his or her lifetime and who currently smokes cigarettes. Includes daily smokers and non-daily smokers (also known as occasional smokers).	Current Smoker | tobacco_smoking_status	C19796	tobacco_smoking_status
C	C177537	GDC Value Terminology	C67493	High-Grade Biliary Intraepithelial Neoplasia	Biliary intraepithelial neoplasia characterized by the presence of high grade epithelial dysplasia.	8148/2 | morphology || Biliary intraepithelial neoplasia, grade 3 | primary_diagnosis || Biliary intraepithelial neoplasia, high grade | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C6867	Myelodysplastic Syndrome with del(5q)	A myelodysplastic syndrome characterized by a deletion between bands q31 and 33 on chromosome 5.  The number of blasts in the bone marrow and blood is <5%.  The bone marrow is usually hypercellular or normocellular with increased number of often hypolobated megakaryocytes.  The peripheral blood shows macrocytic anemia.  This syndrome occurs predominantly but not exclusively in middle age to older women.  The prognosis is good and transformation to acute leukemia is rare.  (WHO, 2001)	9986/3 | morphology || Myelodysplastic syndrome with 5q deletion (5q-) syndrome | primary_diagnosis || Myelodysplastic syndrome with isolated del (5q) | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C6996	Uterine Corpus Adenomyosis	The growth of endometrial tissue inside the muscular wall of the uterine corpus. Clinical manifestations include pain, dysmenorrhea, and menorrhagia.	Adenomyosis | additional_pathology_findings || Adenomyosis | risk_factors	C158809 || C17103	additional_pathology_findings || risk_factors
C	C177537	GDC Value Terminology	C70658	ISS Stage I Multiple Myeloma	Multiple myeloma with beta-2-microglobulin less than 3.5 and albumin greater than or equal to 3.5 (median survival of 62 months).  Note that the older Durie/Salmon staging system defines stage I quite differently. (PDQ)	I | iss_stage	C139007	iss_stage
C	C177537	GDC Value Terminology	C70659	ISS Stage II Multiple Myeloma	Multiple myeloma with blood levels of beta-2-microglobulin between 3.5 and 5.5 mg/L.	II | iss_stage	C139007	iss_stage
C	C177537	GDC Value Terminology	C70660	ISS Stage III Multiple Myeloma	Multiple myeloma with beta-2-microglobulin greater than or equal to 5.5 (median survival of 29 months).  Note that the older Durie/Salmon staging system defines stage III quite differently. (PDQ)	III | iss_stage	C139007	iss_stage
C	C177537	GDC Value Terminology	C71079	Herpes Zoster	A common dermal and neurologic disorder caused by reactivation of the varicella-zoster virus that has remained dormant within dorsal root ganglia, often for decades, after the patient's initial exposure to the virus in the form of varicella (chickenpox). It is characterized by severe neuralgic pain along the distribution of the affected nerve and crops of clustered vesicles over the area.	Herpes Zoster | comorbidities || Herpes Zoster | risk_factors || Shingles | comorbidities || Shingles | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C7136	Extracutaneous Mastocytoma	A localized mast cell neoplasm involving extracutaneous sites.	9740/1 | morphology || Extracutaneous mastocytoma | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C7138	Solitary Mastocytoma of the Skin	A benign, solitary, well-demarcated, yellow-brown or reddish-brown mast cell neoplasm that arises from the skin, most commonly in infants and children. The lesions are typically 2-5 cm in size, are characterized by infiltration of the dermis by neoplastic mast cells, and occasionally resolve spontaneously.	9740/1 | morphology || Solitary mastocytoma of skin | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C7151	Monoclonal Immunoglobulin Deposition Disease	A mature B-cell neoplasm characterized by the deposition of immunoglobulin in tissues, resulting in impaired organ function. It includes the following entities: primary amyloidosis, heavy chain deposition disease, and light chain deposition disease.	9769/1 | morphology || Immunoglobulin deposition disease | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C7168	Myelodysplastic Syndrome/Acute Myeloid Leukemia	A myelodysplastic syndrome characterized by the presence of dysplasia in one or more hematopoietic cell lineages and 10-19% blasts in bone marrow or peripheral blood.	RAEB II | primary_diagnosis	C177621	primary_diagnosis
C	C177537	GDC Value Terminology	C7230	Primary Cutaneous Marginal Zone Lymphoproliferative Disorder	A B-cell lymphoproliferative disorder that arises from the skin. It was previously known as primary cutaneous marginal zone lymphoma of mucosa-associated lymphoid tissue. Two subtypes are recognized: heavy chain class-switched primary cutaneous marginal zone lymphoproliferative disorder and IgM-positive primary cutaneous marginal zone lymphoproliferative disorder. The majority of cases are class-switched and predominantly IgG-positive.	9699/3 | morphology || SALT lymphoma | primary_diagnosis || Skin-associated lymphoid tissue lymphoma | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C7318	Acute Monoblastic and Monocytic Leukemia	Acute myeloid leukemia in which 80% or more of the leukemic cells are of monocytic lineage, including monoblasts, promonocytes, and monocytes. Bleeding disorders are common presenting features.	9891/3 | morphology || Acute monoblastic and monocytic leukemia | primary_diagnosis || FAB M5 (includes all variants) | primary_diagnosis || M5 | fab_morphology_code	C176985 || C177621 || C91220	morphology || primary_diagnosis || fab_morphology_code
C	C177537	GDC Value Terminology	C7463	Acute Myelomonocytic Leukemia	An acute leukemia characterized by the proliferation of both neutrophil and monocyte precursors.  (WHO, 2001)	9867/3 | morphology || Acute myelomonocytic leukemia | primary_diagnosis || FAB M4 | primary_diagnosis || M4 | fab_morphology_code	C176985 || C177621 || C91220	morphology || primary_diagnosis || fab_morphology_code
C	C177537	GDC Value Terminology	C7506	Myelodysplastic Syndrome with Excess Blasts	A myelodysplastic syndrome characterized by the presence of 5-9% blasts in the bone marrow and 2-9% blasts in the peripheral blood.	9983/3 | morphology || RAEB | primary_diagnosis || RAEB I | primary_diagnosis || Refractory anemia with excess blasts | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C75466	Rubinstein-Taybi Syndrome	A rare genetic syndrome mapped to chromosome 16p13.3 and associated with mutations in the CREBBP gene. It is characterized by mental and growth retardation, distinctive facial features (prominent nose, low-set ears, microcephaly, and small mouth), and broad thumbs and great toes. Patients are at an increased risk of developing benign and malignant neoplasms, including nervous system neoplasms and malignant lymphoproliferative disorders.	Rubinstein-Taybi Syndrome | comorbidities || Rubinstein-Taybi Syndrome | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C75545	Hemolytic Uremic Syndrome	Acute kidney injury associated with microangiopathic hemolytic anemia and thrombocytopenia.	HUS/TTP | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C7600	Acute Myeloid Leukemia with Myelodysplasia-Related Changes	An acute myeloid leukemia with at least 20% blasts in the bone marrow or blood, and either a previous history of myelodysplastic syndrome, multilineage dysplasia or myelodysplastic syndrome-related cytogenetic abnormalities.  There is no history of prior cytotoxic therapy for an unrelated disorder, and there is absence of the molecular abnormalities that are present in acute myeloid leukemia with recurrent genetic abnormalities.	9895/3 | morphology || Acute myeloid leukemia with myelodysplasia-related changes | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C77643	Paraaortic Lymph Node	A lymph node located adjacent to the lumbar region of the spine.	Aortic | lymph_node_involved_site || Lymph Node(s) Paraaortic | biospecimen_anatomic_site || Lymph Node(s) Paraaortic | treatment_anatomic_site || Paraaortic | lymph_node_involved_site || Paraaortic lymph nodes | max_tumor_bulk_site	C171435 || C188396 || C33027 || C70729	biospecimen_anatomic_site || max_tumor_bulk_site || lymph_node_involved_site || treatment_anatomic_site
C	C177537	GDC Value Terminology	C78393	Iron Overload	Accumulation of iron in the tissues. It may be a manifestation of an inherited disorder (e.g., hemochromatosis) or acquired (in patients with repeated blood transfusions). Symptoms include hepatomegaly, arthritis, diabetes mellitus, and bronzed skin. If untreated it has a progressive course and may lead to death.	Iron Overload | comorbidities || Iron Overload | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C78578	Pulmonary Hemorrhage	Bleeding from the lung parenchyma.	Pulmonary Hemorrhage | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C78797	Thrombotic Thrombocytopenic Purpura	A coagulation disorder characterized by extensive formation of thrombi in small blood vessels throughout the body due to low levels of ADAMTS13 protein, and resulting in consumption of circulating platelets, which is characterized by thrombocytopenia, anemia, neurologic changes, and sometimes fever and renal dysfunction.	HUS/TTP | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C79596	Hepatic Encephalopathy	A constellation of signs and symptoms characterized by changes in personality, consciousness, and reflexes, resulting from neuropsychiatric abnormalities secondary to liver failure without evidence of other brain disease.	Hepatic Encephalopathy | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C79798	Veligrotug	A humanized monoclonal antibody directed against the human insulin-like growth factor-1 receptor (IGF-1R/CD221) with potential antineoplastic activity. Veligrotug specifically binds to and blocks membrane-bound IGF-1R, preventing the binding of the natural ligand IGF-1 and the subsequent activation of PI3K/AKT signal transduction, which may result in the induction of apoptosis and a decrease in cellular proliferation. Activation of IGF-1R, a receptor tyrosine kinase of the insulin receptor superfamily overexpressed by various cancer cell types, stimulates cell proliferation, promotes angiogenesis, enables oncogenic transformation, and suppresses apoptosis.	Anti-IGF-1R Monoclonal Antibody AVE1642 | therapeutic_agents	C1909	therapeutic_agents
C	C177537	GDC Value Terminology	C80078	Chronic Kidney Disease	Impairment of the renal function secondary to chronic kidney damage persisting for three or more months.	Chronic Kidney Disease | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C80326	B Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified	B-lymphoblastic leukemias/lymphomas characterized by the absence of recurrent genetic abnormalities.	9811/3 | morphology || B lymphoblastic leukemia/lymphoma, NOS | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C80332	B Lymphoblastic Leukemia/Lymphoma with t(v;11q23.3); KMT2A Rearranged	A precursor lymphoid neoplasm which is composed of B-lymphoblasts and carries a translocation between the KMT2A gene at 11q23.3 and another gene partner resulting in the production of an KMT2A related fusion protein.	9813/3 | morphology || B lymphoblastic leukemia/lymphoma with t(v;11q23); MLL rearranged | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C80335	Hyperdiploid B Lymphoblastic Leukemia/Lymphoma	A precursor lymphoid neoplasm composed of B-lymphoblasts which contain more than 50 and usually less than 66 chromosomes. It has a favorable clinical outcome.	9815/3 | morphology || B lymphoblastic leukemia/lymphoma with hyperdiploidy | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C80338	Hypodiploid  B Lymphoblastic Leukemia/Lymphoma	A precursor lymphoid neoplasm composed of B-lymphoblasts which contain less than 46 chromosomes. It has an unfavorable clinical outcome.	9816/3 | morphology || B lymphoblastic leukemia/lymphoma with hypodiploidy (Hypodiploid ALL) | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C80341	B Lymphoblastic Leukemia/Lymphoma with t(1;19)(q23;p13.3); TCF3-PBX1	A precursor lymphoid neoplasm which is composed of B-lymphoblasts and carries a translocation between the E2A gene on chromosome 19 and the PBX1 gene on chromosome 1.	9818/3 | morphology || B lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3); E2A-PBX1 (TCF3-PBX1) | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C80385	Dyslipidemia	A lipoprotein metabolism disorder characterized by decreased levels of high-density lipoproteins, or elevated levels of plasma cholesterol, low-density lipoproteins and/or triglycerides.	Dyslipidemia | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C812	Ribonucleic Acid	Single-stranded long chain of nucleotides containing ribose. It is the end product of DNA transcription by the enzyme RNA polymerase. It is essential in protein synthesis.	RNA | analyte_type	C156434	analyte_type
C	C177537	GDC Value Terminology	C82203	Mixed Phenotype Acute Leukemia with t(v;11q23.3); KMT2A Rearranged	A rare mixed phenotype acute leukemia in which the blasts carry a translocation between the MLL (KMT2A) gene at 11q23.3 and another gene partner. The prognosis is usually unfavorable.	9807/3 | morphology || Mixed phenotype acute leukemia with t(v;11q23); MLL rearranged | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C82403	Acute Myeloid Leukemia with t(9;11)(p21.3;q23.3); MLLT3- KMT2A	An acute myeloid leukemia associated with t(9;11)(p21.3;q23.3) and MLLT3-KMT2A fusion protein expression. Morphologically it usually has monocytic features. It may present at any age but it is more commonly seen in children. Patients may present with disseminated intravascular coagulation.	Acute myeloid leukemia with t(9;11)(p22;q23); MLLT3-MLL | primary_diagnosis	C177621	primary_diagnosis
C	C177537	GDC Value Terminology	C82423	Acute Myeloid Leukemia with t(6;9) (p22.3;q34.1); DEK-NUP214	An acute myeloid leukemia associated with t(6;9)(p22.3;q34.1) resulting in DEK-NUP214(CAN) fusion protein expression. It is often associated with multilineage dysplasia and basophilia. It affects both children and adults and it usually has an unfavorable clinical outcome.	9865/3 | morphology || Acute myeloid leukemia with t(6;9)(p23;q34); DEK-NUP214 | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C82596	Refractory Cytopenia of Childhood	A myeloid disorder that occurs in childhood and is characterized by persistent cytopenia, dysplastic changes in at least two hematopoietic lineages or in 10% or more of cells in one hematopoietic lineage, less than 5% blasts in bone marrow, and less than 2% blasts in peripheral blood, absence of bone marrow fibrosis, and absence of history of prior cytotoxic chemotherapy or radiation therapy. In a subset of cases, somatic mutations or cytogenetic abnormalities can be identified. Other cases are the result of pre-existing disorders with germline mutations, including Fanconi anemia, Shwachman-Diamond syndrome, and dyskeratosis congenita.	9985/3 | morphology || Refractory cytopenia of childhood | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C82616	Myelodysplastic/Myeloproliferative Neoplasm with Ring Sideroblasts and Thrombocytosis, Not Otherwise Specified	A myelodysplastic/myeloproliferative neoplasm characterized by marked thrombocytosis, anemia, erythroid lineage dysplasia, presence or absence of multilineage dysplasia, 15% or more ring sideroblasts, blasts less than 5% in bone marrow and less than 1% in peripheral blood, absence of BCR/ABL fusion, absence of SF3B1 mutation, absence of genetic abnormalities associated with myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions, and no history of other myelodysplastic/myeloproliferative neoplasms or myeloproliferative neoplasms and myelodysplastic syndromes.	9982/3 | morphology || Refractory anemia with ring sideroblasts associated with marked thrombocytosis | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C82892	Hemochromatosis	Accumulation of iron in internal organs.	Hemochromatosis | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C82978	Chronic Hepatitis	An active inflammatory process affecting the liver for more than six months. Causes include viral infections, autoimmune disorders, drugs, and metabolic disorders.	Chronic Hepatitis | risk_factors || Hepatitis, Chronic | comorbidities	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C82980	Fungal Colonization	Collection of fungal organisms in an anatomic site or medical device.	Colonization, Fungal | risk_factors || Colonization; fungal | additional_pathology_findings	C158809 || C17103	additional_pathology_findings || risk_factors
C	C177537	GDC Value Terminology	C8360	Intestinal Metaplasia	A morphologic finding indicating the replacement of epithelial tissue outside the intestines by intestinal-type epithelium.	Intestinal Metaplasia | risk_factors || Intestinal metaplasia | additional_pathology_findings	C158809 || C17103	additional_pathology_findings || risk_factors
C	C177537	GDC Value Terminology	C8366	Intraepithelial Neoplasia	A precancerous neoplastic process that affects the squamous, glandular, or transitional cell epithelium without evidence of invasion. According to the degree of nuclear atypia, number of mitotic figures, and presence of architectural distortion, it is classified as low grade (mild dysplasia) or high grade (moderate or severe dysplasia).	Epithelial | dysplasia_type || Epithelial Dysplasia | risk_factors || Epithelial dysplasia | additional_pathology_findings	C158809 || C17103 || C4086	additional_pathology_findings || risk_factors || dysplasia_type
C	C177537	GDC Value Terminology	C84397	Alpha-1 Antitrypsin Deficiency	A genetic disorder characterized by decreased alpha-1 antitrypsin activity in the lungs and blood and deposition of alpha-1 antitrypsin protein in the hepatocytes. These abnormalities result from defective production of alpha-1 antitrypsin and lead to the development of emphysema, cirrhosis, and liver failure.	Alpha-1 Antitrypsin | comorbidities || Alpha-1 Antitrypsin Deficiency | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C84442	Metabolic Syndrome	A combination of medical conditions that when present, increase the risk of heart attack, stroke, and diabetes mellitus. It includes the following medical conditions: increased blood pressure, central obesity, dyslipidemia, impaired glucose tolerance, and insulin resistance.	Metabolic Syndrome | comorbidities || Metabolic Syndrome | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C84444	Nonalcoholic Fatty Liver Disease	A term referring to fatty replacement of the hepatic parenchyma which is not related to alcohol use.	Nonalcoholic Fatty Liver Disease | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C84445	Nonalcoholic Steatohepatitis	Fatty replacement and damage to the hepatocytes not related to alcohol use. It may lead to cirrhosis and liver failure.	Nonalcoholic Steatohepatitis | comorbidities || Nonalcoholic Steatohepatitis | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C84507	Buffy Coat	The middle layer of an anticoagulated blood specimen following separation by centrifugation. It contains most of the white blood cells and platelets.	Buffy Coat | biospecimen_type || Buffy Coat | specimen_type	C70713 || C83315	specimen_type || biospecimen_type
C	C177537	GDC Value Terminology	C84513	Whole Bone Marrow	Bone marrow sample containing a mixture of different types of stem cells, including hematopoietic stem cells, mesenchymal stem cells, and multipotent progenitor cells.	Whole Bone Marrow | specimen_type	C70713	specimen_type
C	C177537	GDC Value Terminology	C8460	Acute Myeloid Leukemia with Minimal Differentiation	An acute myeloid leukemia (AML) in which the blasts do not show evidence of myeloid differentiation by morphology and conventional cytochemistry. (WHO, 2001)	9872/3 | morphology || Acute myeloid leukemia, minimal differentiation | primary_diagnosis || FAB MO | primary_diagnosis || M0 | fab_morphology_code	C176985 || C177621 || C91220	morphology || primary_diagnosis || fab_morphology_code
C	C177537	GDC Value Terminology	C84668	Denys-Drash Syndrome	A rare congenital syndrome caused by mutations in the WT1 gene. It is characterized by the presence of congenital nephropathy (diffuse mesangial sclerosis), Wilms tumor, and intersex disorders.	Denys-Drash Syndrome | comorbidities || Denys-Drash Syndrome | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C84729	Gilbert Syndrome	An autosomal recessive inherited disorder characterized by unconjugated hyperbilirubinemia, resulting in harmless intermittent jaundice.	Gilbert's Syndrome | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C84858	MEK Inhibitor REC-4881	An orally bioavailable, non-ATP-competitive, allosteric, small-molecule inhibitor of mitogen-activated protein kinase kinase (MAP2K; MAPK/ERK kinase; MEK) 1 and MEK2, with potential antineoplastic activity. Upon oral administration, MEK inhibitor REC-4881 selectively binds to and inhibits the activity of MEK1/2. This prevents the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK1/2 (MAP2K1/K2) are dual-specificity threonine/tyrosine kinases that play key roles in the activation of the RAS/RAF/MEK/ERK pathway and are often upregulated in a variety of tumor cell types.	MEK Inhibitor TAK-733 | therapeutic_agents	C1909	therapeutic_agents
C	C177537	GDC Value Terminology	C84860	Onvitrelin Ucalontide	A water-soluble, positively charged fusion protein consisting of a luteinizing hormone releasing hormone (LHRH) receptor-targeting ligand conjugated to the membrane-disrupting peptide CLIP 71 with membrane-disrupting and potential antineoplastic activities. The LHRH ligand moiety of onvitrelin ucalontide specifically binds to LHRH receptors, which are upregulated on a variety of human cancer cell types. Subsequently, the positively charged CLIP 71 moiety of this agent interacts with the negatively charged membrane on the cancer cell surface, which may result in cell membrane disruption and cell lysis.	Membrane-Disrupting Peptide EP-100 | therapeutic_agents	C1909	therapeutic_agents
C	C177537	GDC Value Terminology	C8494	Lynch Syndrome	An autosomal dominant hereditary neoplastic syndrome characterized by the development of colorectal carcinoma and a high risk of developing endometrial carcinoma, gastric carcinoma, ovarian carcinoma, renal pelvis carcinoma, and small intestinal carcinoma. Patients often develop colorectal carcinomas at an early age (mean, 45 years). In the majority of the cases the lesions arise from the proximal colon. At the molecular level, high-frequency microsatellite instability is present.	Lynch Syndrome | comorbidities || Lynch Syndrome | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C8509	Primary Neoplasm	A tumor at the original site of origin.	Primary | tumor_descriptor || primary | classification_of_tumor	C166229 || C174459	tumor_descriptor || classification_of_tumor
C	C177537	GDC Value Terminology	C85197	Treponemal Infection	A sexually transmitted infection caused by the Gram-negative spirochete Treponema pallidum. It is manifested as syphilis.	Treponema pallidum | comorbidities || Treponema pallidum | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C8563	Undifferentiated High Grade Pleomorphic Sarcoma of Bone	A rare, high-grade pleomorphic malignant neoplasm arising from the bone.  It usually presents with pain which may or may not be associated with swelling in the affected area.  It is characterized by the presence of spindle-shaped cells, polygonal or epithelioid cells, multinucleated giant cells, and inflammatory cells.  The neoplastic cells exhibit nuclear pleomorphism and high mitotic activity.  It metastasizes frequently, most often in the lungs.	Malignant fibrous histiocytoma (MFH) of bone | primary_diagnosis || Undifferentiated high-grade pleomorphic sarcoma | primary_diagnosis	C177621	primary_diagnosis
C	C177537	GDC Value Terminology	C8574	Myelodysplastic Syndrome, Not Otherwise Specified with Multilineage Dysplasia	A myelodysplastic syndrome characterized by bi-cytopenia or pancytopenia and dysplastic changes in 10% or more of the cells in two or more of the myeloid cell lines. (WHO, 2001)	9985/3 | morphology || Refractory cytopenia with multilineage dysplasia | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C86172	Bacteroides fragilis	A species of obligately anaerobic, Gram-negative, rod shaped bacteria assigned to the phylum Bacteroidetes. This species is nonmotile, non-spore forming, indole positive, produces hydrogen sulfide, does not reduce nitrate, hydrolyzes esculin and starch, does not ferment trehalose, melezitose or arabinose, and is penicillin resistant. B. fragilis is commensal and part of the normal human gastrointestinal tract flora, but may become pathogenic in other body regions.	Bacteroides fragilis | comorbidities || Bacteroides fragilis | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C87497	Fibromyalgia	A chronic disorder of unknown etiology characterized by pain, stiffness, and tenderness in the muscles of neck, shoulders, back, hips, arms, and legs. Other signs and symptoms include headaches, fatigue, sleep disturbances, and painful menstruation.	Fibromyalgia | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C88541	Hemihypertrophy	A finding indicating the presence of greater than normal asymmetry between the right and left sides of the body. The asymmetry may be manifested in the entire side or part of it.	Hemihypertrophy | comorbidities || Hemihypertrophy | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C892	Smokeless Tobacco	Tobacco that is not smoked but used in another form such as chewing tobacco or snuff.	Smokeless Tobacco | type_of_tobacco_used	C177629	type_of_tobacco_used
C	C177537	GDC Value Terminology	C8923	Acute Erythroid Leukemia	An acute myeloid leukemia characterized by a predominant immature erythroid population.  There are two subtypes recognized: erythroleukemia and pure erythroid leukemia. (WHO, 2001)	9840/3 | morphology || AML M6 | primary_diagnosis || Acute erythremia | primary_diagnosis || Acute erythroid leukaemia | primary_diagnosis || Acute myeloid leukemia, M6 type | primary_diagnosis || FAB M6 | primary_diagnosis || M6 | fab_morphology_code	C176985 || C177621 || C91220	morphology || primary_diagnosis || fab_morphology_code
C	C177537	GDC Value Terminology	C8960	Hereditary Kidney Oncocytoma	An inherited condition characterized by the development of kidney oncocytomas which are often bilateral and multifocal.  This condition may be connected to Birt-Hogg-Dube syndrome.	Hereditary Kidney Oncocytoma | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C8991	Malignant Mastocytosis	A group of malignant mast cell disorders including aggressive systemic mastocytosis, mast cell leukemia, mast cell sarcoma, and systemic mastocytosis with an associated myeloid neoplasm. Individuals with advanced systemic mastocytosis have a reduced life expectancy, with median survival measured in months to years.	9741/3 | morphology || Malignant mastocytosis | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C9004	Benign Adrenal Cortical Neoplasm	A neoplasm that arises from the adrenal cortex and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential.	8370/0 | morphology || Adrenal cortical tumor, benign | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C90169	Persistent Disease	A disease that does not go to remission despite treatment.	Persistent Disease | initial_disease_status || Persistent Disease | treatment_outcome	C177616 || C18919	initial_disease_status || treatment_outcome
C	C177537	GDC Value Terminology	C9128	Chronic Myeloid Leukemia, Philadelphia Chromosome Positive, BCR-ABL1 Positive	A chronic myeloid leukemia characterised by the t(9;22)(q34;q11) chromosomal translocation, resulting in the presence of the Philadelphia chromosome and the BCR-ABL1 fusion gene.	9875/3 | morphology || Chronic granulocytic leukemia, BCR/ABL | primary_diagnosis || Chronic granulocytic leukemia, Philadelphia chromosome (Ph1) positive | primary_diagnosis || Chronic granulocytic leukemia, t(9;22)(q34;q11) | primary_diagnosis || Chronic myelogenous leukemia, Philadelphia chromosome (Ph 1) positive | primary_diagnosis || Chronic myelogenous leukemia, t(9;22)(q34;q11) | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C92188	Seasonal Allergic Rhinitis	Allergic rhinitis caused by outdoor allergens.	Hay Fever | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C9222	Hereditary Papillary Renal Cell Carcinoma	A familial carcinoma inherited in an autosomal dominant trait.  It is characterized by the development of multiple, bilateral papillary renal cell carcinomas.  The carcinomas range from microscopic lesions to clinically symptomatic tumors.  It is associated with activating mutations of the MET oncogene.	Hereditary Papillary Renal Cell Carcinoma | risk_factors	C17103	risk_factors
C	C177537	GDC Value Terminology	C9233	Juvenile Myelomonocytic Leukemia	A clonal myeloid disorder of childhood previously classified as myelodysplastic/myeloproliferative neoplasm. It is characterized by the presence of monocytic proliferation in peripheral blood, less than 20% blasts in bone marrow and peripheral blood, splenomegaly, and the absence of BCR-ABL1 fusion. Almost all patients carry mutations of the RAS pathway.	9946/3 | morphology || Juvenile chronic myelomonocytic leukemia | primary_diagnosis || Juvenile myelomonocytic leukemia | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C9235	Systemic Mastocytosis	Systemic infiltration of extracutaneous sites by clonal mast cells, with or without evidence of skin involvement.	9741/3 | morphology || Systemic tissue mast cell disease | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C9284	Systemic Mastocytosis with an Associated Myeloid Neoplasm	A disorder characterized by systemic infiltration of internal organs by aggregates of clonal mast cells and the presence of a clonal non-mast cell myeloid neoplasm (e.g., myelodysplastic syndrome, myeloproliferative neoplasm, and acute myeloid leukemia).	9741/3 | morphology || Systemic mastocytosis with AHNMD | primary_diagnosis || Systemic mastocytosis with associated hematological clonal non-mast cell disorder | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
C	C177537	GDC Value Terminology	C9305	Malignant Neoplasm	A neoplasm composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas, Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas.	8000/3 | morphology || Cancer | comorbidities || Cancer | primary_diagnosis || Cancer | relationship_primary_diagnosis || Cancer | risk_factors || Malignancy | primary_diagnosis || Neoplasm, malignant | primary_diagnosis || Tumor, malignant, NOS | primary_diagnosis || Unclassified tumor, malignant | primary_diagnosis	C16457 || C17103 || C176985 || C177621 || C178243	comorbidities || risk_factors || morphology || primary_diagnosis || relationship_primary_diagnosis
C	C177537	GDC Value Terminology	C9357	Hodgkin Lymphoma	A lymphoma, previously known as Hodgkin's disease, characterized by the presence of large tumor cells in an abundant admixture of nonneoplastic cells. There are two distinct subtypes: nodular lymphocyte predominant Hodgkin lymphoma and classical Hodgkin lymphoma. Hodgkin lymphoma involves primarily lymph nodes.	9650/3 | morphology || Hodgkin Lymphoma | disease_type || Hodgkin Lymphoma | risk_factors || Hodgkin Lymphoma | comorbidities || Hodgkin Lymphoma | risk_factors || Hodgkin disease, NOS | primary_diagnosis || Hodgkin lymphoma, NOS | primary_diagnosis || Malignant lymphoma, Hodgkin | primary_diagnosis	C16457 || C17103 || C176985 || C177621 || C2991	comorbidities || risk_factors || morphology || primary_diagnosis || disease_type
C	C177537	GDC Value Terminology	C94219	Acimtamig	A tetravalent bispecific antibody directed against human CD30 and the human low affinity IgG Fc region receptor (FCGR3A; CD16A), with potential immunomodulating and antineoplastic activities. Upon administration, acimtamig binds to the CD16A expressed on natural killer (NK) cells with two of its binding sites and to CD30 on CD30-expressing tumor cells with the other two binding sites, thereby selectively cross-linking tumor and NK cells. This may result in NK cell activation, antibody-dependent cellular cytotoxicity (ADCC) and eventually tumor cell lysis. CD30, a cell surface receptor and a member of the tumor necrosis factor (TNF) receptor superfamily, is overexpressed in hematologic malignancies; CD16A is specifically expressed on the surface of NK cells.	Anti-CD30/CD16A Monoclonal Antibody AFM13 | therapeutic_agents	C1909	therapeutic_agents
C	C177537	GDC Value Terminology	C9438	Chronic Renal Failure	Impairment of the renal function due to chronic kidney damage.	Chronic Renal Failure | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C95805	T1mi TNM Finding	A term that refers to a TNM finding of a primary tumor limited to the site of growth and indicates microinvasion only.	T1mi | ajcc_clinical_t || T1mi | ajcc_pathologic_t || T1mi | uicc_clinical_t || T1mi | uicc_pathologic_t	C177635 || C177636 || C188411 || C188448	ajcc_clinical_t || ajcc_pathologic_t || uicc_clinical_t || uicc_pathologic_t
C	C177537	GDC Value Terminology	C95921	N0 (i-) TNM Finding	A regional lymph node TNM finding indicating that there is no evidence of regional lymph node metastasis histologically, and immunohistochemistry is negative.	N0 (i-) | ajcc_clinical_n || N0 (i-) | ajcc_pathologic_n || N0 (i-) | uicc_clinical_n || N0 (i-) | uicc_pathologic_n	C177611 || C177612 || C188408 || C188429	ajcc_clinical_n || ajcc_pathologic_n || uicc_clinical_n || uicc_pathologic_n
C	C177537	GDC Value Terminology	C95922	N0 (i+) TNM Finding	A regional lymph node TNM finding indicating that there are malignant cells in regional lymph node(s) no greater than 0.2 mm and are detected by hematoxylin and eosin stain or immunohistochemistry.	N0 (i+) | ajcc_clinical_n || N0 (i+) | ajcc_pathologic_n || N0 (i+) | uicc_clinical_n || N0 (i+) | uicc_pathologic_n	C177611 || C177612 || C188408 || C188429	ajcc_clinical_n || ajcc_pathologic_n || uicc_clinical_n || uicc_pathologic_n
C	C177537	GDC Value Terminology	C95923	N0 (mol-) TNM Finding	A regional lymph node TNM finding indicating that there is no evidence of regional lymph node metastasis histologically and molecular analysis (RT-PCR) is negative.	N0 (mol-) | ajcc_clinical_n || N0 (mol-) | ajcc_pathologic_n || N0 (mol-) | uicc_clinical_n || N0 (mol-) | uicc_pathologic_n	C177611 || C177612 || C188408 || C188429	ajcc_clinical_n || ajcc_pathologic_n || uicc_clinical_n || uicc_pathologic_n
C	C177537	GDC Value Terminology	C95925	N0 (mol+) TNM Finding	A regional lymph node TNM finding indicating that there is no evidence of regional lymph node metastasis histologically and by immunohistochemistry, but the molecular analysis (RT-PCR) is positive.	N0 (mol+) | ajcc_clinical_n || N0 (mol+) | ajcc_pathologic_n || N0 (mol+) | uicc_clinical_n || N0 (mol+) | uicc_pathologic_n	C177611 || C177612 || C188408 || C188429	ajcc_clinical_n || ajcc_pathologic_n || uicc_clinical_n || uicc_pathologic_n
C	C177537	GDC Value Terminology	C95955	N1mi TNM Finding	A regional lymph node TNM finding indicating the presence of micrometastases (greater than 0.2 mm and/or more than 200 cells, but none greater than 2.0 mm).	N1mi | ajcc_clinical_n || N1mi | ajcc_pathologic_n || N1mi | uicc_clinical_n || N1mi | uicc_pathologic_n	C177611 || C177612 || C188408 || C188429	ajcc_clinical_n || ajcc_pathologic_n || uicc_clinical_n || uicc_pathologic_n
C	C177537	GDC Value Terminology	C95956	cM0 (i+) TNM Finding	A distant metastasis TNM finding indicating that there is no evidence of distant metastasis clinically or by radiologic studies, but there are small numbers of cells detected by special studies in the blood and bone marrow, or there is tiny metastasis (no larger than 0.2 mm) detected in nonregional lymph nodes.	cM0 (i+) | ajcc_clinical_m || cM0 (i+) | ajcc_pathologic_m || cM0 (i+) | uicc_clinical_m || cM0 (i+) | uicc_pathologic_m	C177606 || C177607 || C188406 || C188415	ajcc_clinical_m || ajcc_pathologic_m || uicc_clinical_m || uicc_pathologic_m
C	C177537	GDC Value Terminology	C96025	Ta TNM Finding	A term that refers to a TNM finding of a primary, non-invasive, papillary cancer.	Ta | ajcc_clinical_t || Ta | ajcc_pathologic_t || Ta | uicc_clinical_t || Ta | uicc_pathologic_t	C177635 || C177636 || C188411 || C188448	ajcc_clinical_t || ajcc_pathologic_t || uicc_clinical_t || uicc_pathologic_t
C	C177537	GDC Value Terminology	C96026	N4 TNM Finding	A general term that refers to a TNM finding of cancer metastases in multiple lymph nodes. The definition of N4 TNM finding depends on the specific type of cancer that it refers to; for example, for ocular adnexal lymphoma it refers to metastases to central lymph nodes.	N4 | ajcc_clinical_n || N4 | ajcc_pathologic_n || N4 | uicc_clinical_n || N4 | uicc_pathologic_n	C177611 || C177612 || C188408 || C188429	ajcc_clinical_n || ajcc_pathologic_n || uicc_clinical_n || uicc_pathologic_n
C	C177537	GDC Value Terminology	C96407	Varicella Zoster Infection	A highly contagious viral infection caused by the varicella zoster virus. Clinically, it may be manifested as shingles or chicken pox.	Varicella Zoster Infection | comorbidities || Varicella Zoster Infection | risk_factors	C16457 || C17103	comorbidities || risk_factors
C	C177537	GDC Value Terminology	C96768	High Grade Liver Dysplastic Nodule	A hepatic dysplastic nodule characterized by the presence of high grade atypical cellular changes.	High Grade Liver Dysplastic Nodule | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C96770	Low Grade Liver Dysplastic Nodule	A hepatic dysplastic nodule characterized by the presence of low grade atypical cellular changes.	Low Grade Liver Dysplastic Nodule | comorbidities	C16457	comorbidities
C	C177537	GDC Value Terminology	C98640	Tyrosinemia	An autosomal recessive inherited metabolic disorder caused by mutations in the FAH, HPD, and TAT genes. It is characterized by deficiency of one of the enzymes that are involved in the metabolism of tyrosine. It results in elevated blood tyrosine levels and accumulation of tyrosine and its byproducts in the liver, kidney, nervous system and other organs.	Tyrosinemia | comorbidities	C16457	comorbidities
A	C177537	GDC Value Terminology	C104011	Nuclear Grade III or IV	Nuclear pleomorphism in tumor cells defined either as grade III or IV.	Nuclear Grade III or IV | weiss_assessment_findings	C104015	weiss_assessment_findings
A	C177537	GDC Value Terminology	C113208	Hypercortisolemia	Abnormally high level of cortisol in the blood.	Cortisol Excess | risk_factors	C17103	risk_factors
A	C177537	GDC Value Terminology	C113215	Androgen Excess	Excessive secretion of androgens from the adrenal glands or gonads. Clinical manifestations may include virilization.	Androgen Excess | risk_factors	C17103	risk_factors
A	C177537	GDC Value Terminology	C113344	Hyperestrogenism	Abnormally high level of estrogen.	Estrogen Excess | risk_factors	C17103	risk_factors
A	C177537	GDC Value Terminology	C118962	Clinical Trial Censoring	When information on time-to-event is not available due to loss to follow-up or non-occurrence of outcome event before the trial end. The data on that participant is banned or removed from the study data.	Censored | first_event	C198107	first_event
A	C177537	GDC Value Terminology	C119608	t(8;21)	A cytogenetic abnormality that involves a translocation between chromosomes 8 and 21.	t(8;21) | chromosomal_translocation	C3420	chromosomal_translocation
A	C177537	GDC Value Terminology	C121972	Induction Death	Death of the patient due to the toxic side effects of induction therapy.	Induction Death | first_event	C198107	first_event
A	C177537	GDC Value Terminology	C122440	Cooks and Food Preparation Workers	Workers who prepare, season, and cook foods, as well as workers who perform routine tasks under the direction of cooks, chefs, or food service managers.	Cooks | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C122446	Electrical and Electronic Equipment Mechanics, Installers, and Repairers	Workers who install, repair, or replace a variety of electrical equipment in telecommunications, transportation, utilities, and other industries.	Electrical Equipment Installers and Repairers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C122447	Engineers	A professional practitioner of engineering, concerned with applying scientific knowledge, mathematics, and ingenuity to develop solutions for technical, societal and commercial problems. Engineers design materials, structures, and systems while considering the limitations imposed by practicality, regulation, safety, and cost.	Engineering Professionals (excluding Electrotechnology) | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C122451	Financial Clerks	Workers who do administrative work for financial institutions or within the financial industries.	Tellers, Money Collectors and Related Clerks | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C122452	Financial Specialists	Workers who meet with customers to help them determine their short-term and long-term financial goals and provide insurance, investment services, certificates of deposits and other financial instruments. They also contact prospective customers, evaluate costs and revenue, make financial presentations and review business trends.	Finance Professionals | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C122460	Food and Beverage Serving Workers	Workers who perform a variety of customer service, food preparation, and cleaning duties in restaurants, cafeterias, and other eating and drinking establishments.	Waiters and Bartenders | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C122473	Librarians, Curators, and Archivists	Workers who appraise, edit, and maintain permanent records and historically valuable documents; oversee collections of artwork and historic items; restore objects and documents in museum collections and exhibits, and/or help people find information and conduct research for personal and professional use.	Librarians, Archivists and Curators | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C122474	Life Scientists	The group of science professions that include animal scientists, biochemists and biophysicists, epidemiologists, food scientists and technologists, medical scientists, microbiologists, zoologists and wildlife biologists, and soil and plant scientists.	Life Science Professionals | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C122499	Postsecondary Teachers	Postsecondary teachers instruct students in a wide variety of academic and vocational subjects beyond the high school level. They also conduct research and publish scholarly papers and books.	University and Higher Education Teachers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C122501	Printing Workers	Printing workers produce print material in three stages: prepress, press, and binding and finishing. They review specifications, calibrate color settings on printers, identify and fix problems with printing equipment, and assemble pages.	Printing Trades Workers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C122555	Other Sales and Related Workers	Sales and related workers not specifically identified elsewhere.	Other Sales Workers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C122556	Other Teachers and Instructors	Teachers and instructors not specifically identified elsewhere.	Other Teaching Professionals | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C125755	AJCC Cancer Staging Manual 7th Edition	The 7th edition of the criteria developed by the American Joint Committee on Cancer (AJCC) in 2010, used for the classification and staging of neoplastic diseases.	7th | ajcc_staging_system_edition	C177561	ajcc_staging_system_edition
A	C177537	GDC Value Terminology	C126391	Open Surgical Procedure	Traditional surgery using a long incision for visualization and for the insertion of instruments.	Surgery, Open | treatment_type	C25218	treatment_type
A	C177537	GDC Value Terminology	C128099	FIGO Stage IC1	A FIGO stage term that applies to ovarian cancer, fallopian tube cancer, and primary peritoneal cancer. It refers to cancer with surgical spill.	Stage IC1 | figo_stage	C125738	figo_stage
A	C177537	GDC Value Terminology	C128100	FIGO Stage IC2	A FIGO stage term that applies to ovarian cancer, fallopian tube cancer, and primary peritoneal cancer. It refers to cancer with capsule rupture before surgery or tumor on ovarian surface.	Stage IC2 | figo_stage	C125738	figo_stage
A	C177537	GDC Value Terminology	C128101	FIGO Stage IC3	A FIGO stage term that applies to ovarian cancer, fallopian tube cancer, and primary peritoneal cancer. It refers to cancer with malignant cells in the ascites or peritoneal washings.	Stage IC3 | figo_stage	C125738	figo_stage
A	C177537	GDC Value Terminology	C128377	Tuberculosis Infection	The asymptomatic presence of Mycobacterium tuberculosis in the body, which is determined by a positive result to a tuberculin skin test or interferon-gamma release assay.	Mycobacterium tuberculosis | aids_risk_factors	C177623	aids_risk_factors
A	C177537	GDC Value Terminology	C128650	t(6;9)	A cytogenetic abnormality that involves a translocation between chromosomes 6 and 9.	t(6;9) | chromosomal_translocation	C3420	chromosomal_translocation
A	C177537	GDC Value Terminology	C13087	Apex of the Prostate	The lowest part of the prostate gland adjacent to the superior fascia of the urogenital diaphragm.	Apex | tumor_level_prostate	C198205	tumor_level_prostate
A	C177537	GDC Value Terminology	C13088	Base of the Prostate	The uppermost part of the prostate gland adjacent to the bladder wall.	Base | tumor_level_prostate	C198205	tumor_level_prostate
A	C177537	GDC Value Terminology	C13094	Middle Lobe of the Prostate	The upper, smaller part of the prostate between the ejaculatory ducts and the urethra.	Middle | tumor_level_prostate	C198205	tumor_level_prostate
A	C177537	GDC Value Terminology	C131437	Nodular Goiter	Goiter characterized by discrete tissue mass(es) that may or may not produce thyroid hormones.	Thyroid Nodular Hyperplasia | risk_factors	C17103	risk_factors
A	C177537	GDC Value Terminology	C133531	Seventh	Following the sixth position in an ordering or series; coming next after the sixth and just before the eighth in position.	7th | uicc_staging_system_edition	C198206	uicc_staging_system_edition
A	C177537	GDC Value Terminology	C133533	Eighth	Following the seventh position in an ordering or series; coming next after the seventh and just before the ninth in position.	8th | uicc_staging_system_edition	C198206	uicc_staging_system_edition
A	C177537	GDC Value Terminology	C137812	Radiation Boost	One or more extra radiation treatments targeted at the tumor bed, given after the regular sessions of radiation are complete.	Radiation Boost | treatment_intent_type	C54398	treatment_intent_type
A	C177537	GDC Value Terminology	C146985	AJCC Cancer Staging Manual 8th Edition	The 8th edition of the criteria developed by the American Joint Committee on Cancer (AJCC), implemented in 2018, used for the classification and staging of neoplastic diseases.	8th | ajcc_staging_system_edition	C177561	ajcc_staging_system_edition
A	C177537	GDC Value Terminology	C148527	Bilateral Modified Radical Neck Dissection	A surgical procedure in which all the bilateral cervical lymph node groups of the neck are removed but the internal jugular veins, sternocleidomastoid muscles, and/or spinal accessory nerves are preserved.	Functional (Limited) Neck Dissection | lymph_node_dissection_method	C198458	lymph_node_dissection_method
A	C177537	GDC Value Terminology	C15340	Total Pancreatectomy	Surgical removal of the entire pancreas.	Total Pancreatectomy | treatment_type	C25218	treatment_type
A	C177537	GDC Value Terminology	C15406	Cancer Screening	The use of any device, marker, or other means for the purpose of detecting the presence of a tumor, usually before there are any symptoms.	Screening | cancer_detection_method	C198091	cancer_detection_method
A	C177537	GDC Value Terminology	C15679	Consolidation Therapy	Treatment that is given after initial therapy to kill any remaining cancer cells.	Consolidation Therapy | treatment_intent_type	C54398	treatment_intent_type
A	C177537	GDC Value Terminology	C157008	Coke Oven Emission Exposure	Occupational exposure to gases and particulates produced when coal is processed in a coke oven.	Coke Oven Emission | chemical_exposure_type	C198092	chemical_exposure_type
A	C177537	GDC Value Terminology	C15719	Surveillance	The systematic collection, analysis, and interpretation of health data on an ongoing basis.	Surveillance | cancer_detection_method	C198091	cancer_detection_method
A	C177537	GDC Value Terminology	C158707	Post-Adjuvant Therapy	Therapy administered after to the initial therapy.	Post Adjuvant Therapy | timepoint_category	C198201	timepoint_category
A	C177537	GDC Value Terminology	C158753	Post-secondary Therapy	Therapy administered after the second treatment.	Post Secondary Therapy | timepoint_category	C198201	timepoint_category
A	C177537	GDC Value Terminology	C158754	Progression of Disease at Recurrence	At the time of the progression or recurrence of a disease.	Recurrence/Progression | timepoint_category	C198201	timepoint_category
A	C177537	GDC Value Terminology	C158876	Induction Therapy	The first choice of treatment for a particular type of cancer.	Induction | treatment_intent_type	C54398	treatment_intent_type
A	C177537	GDC Value Terminology	C159212	Peripheral Lung Parenchyma Tumor	A response that the parenchyma tumor is in the peripheral lung.	Peripheral Lung | sites_of_involvement	C173263	sites_of_involvement
A	C177537	GDC Value Terminology	C159213	Central Lung Parenchyma Tumor	A response that the parenchyma tumor is in the central lung.	Central Lung | sites_of_involvement	C173263	sites_of_involvement
A	C177537	GDC Value Terminology	C16033	Follow-Up	The process by which information about the health status of an individual is obtained after a study has officially closed; an activity that continues something that has already begun or that repeats something that has already been done.	Follow-up | timepoint_category	C198201	timepoint_category
A	C177537	GDC Value Terminology	C160838	Extranodal Tumor Extension Absent	A response that the extranodal tumor extension is absent.	No Extranodal Extension | extranodal_extension	C160837	extranodal_extension
A	C177537	GDC Value Terminology	C162623	Normal Tissue Segment	Sufficient total material from each patient, divided to yield a minimum of one aliquot, preferably divided into one to three aliquots of non-neoplastic ("normal") adjacent tissue (as feasible) suitable for processing for proteomic and genomic analysis.	Uninvolved Tissue, NOS | biospecimen_type	C83315	biospecimen_type
A	C177537	GDC Value Terminology	C165476	Arsenic Exposure	A finding indicating that an individual has been exposed to arsenic.	Arsenic | chemical_exposure_type	C198092	chemical_exposure_type
A	C177537	GDC Value Terminology	C168447	Symptomatic Presentation	A clinical description in which a patient demonstrates evidence of more than one clinical finding suggestive of underlying pathology. (ACC/AHA)	Symptomatic | cancer_detection_method	C198091	cancer_detection_method
A	C177537	GDC Value Terminology	C168758	t(10;11)(p11.2;q23)	A cytogenetic abnormality that refers to the translocation of the short arm (p11.2) of chromosome 10 and the long arm (q23) of chromosome 11. It is associated with KMT2A (MLL)/ABI1 fusions and acute myeloid leukemia.	t(10;11)(p11.2;q23) | chromosomal_translocation	C3420	chromosomal_translocation
A	C177537	GDC Value Terminology	C168918	Number of Cells in Metaphase during Karyotyping	The number of cells in metaphase during karyotype analysis.	Metaphase Nucleus Count | laboratory_test	C25294	laboratory_test
A	C177537	GDC Value Terminology	C17004	Genetic Polymorphism	The regular and simultaneous occurrence of alternative nucleotide sequences at equivalent locations of the genetic material among individuals of a single interbreeding population that are not maintained by recurrent mutation. Polymorphisms may range in size from single nucleotide to large nucleotide sequence variation visible at the chromosomal level.	Genetic Polymorphism | variant_type	C173544	variant_type
A	C177537	GDC Value Terminology	C172121	Cytoplasmic Immunoglobulin	Immunoglobulins found within intact cells. The proportion of cells expressing cytoplasmic immunoglobulin can be a diagnostic criterion in B-cell lymphoproliferative disorders.	Immunoglobulin, Cytoplasmic | antigen	C268	antigen
A	C177537	GDC Value Terminology	C172727	Minimally Invasive Surgery	Surgery that uses small incision(s) and is intended to produce minimal blood loss and pain for the patient. It also minimizes the risk of post-surgical complications, including less risk of infection, and is expected to reduce recovery time.	Surgery, Minimally Invasive | treatment_type	C25218	treatment_type
A	C177537	GDC Value Terminology	C172804	Low Grade Biliary Intraepithelial Neoplasia	Biliary intraepithelial neoplasia characterized by the presence of low grade epithelial dysplasia.	Biliary intraepithelial neoplasia, low grade | primary_diagnosis	C177621	primary_diagnosis
A	C177537	GDC Value Terminology	C175738	Afamitresgene Autoleucel	A preparation of autologous human T-lymphocytes transduced with a lentiviral vector encoding an affinity-enhanced T-cell receptor (TCR) specific for the human leukocyte antigen (HLA)-A2-restricted peptide human melanoma antigen A4 (MAGE-A4) C1032, with potential immunostimulatory and antineoplastic activities. Upon leukapheresis, isolation, transduction, expansion ex vivo, and reintroduction into the patient, afamitresgene autoleucel targets and binds to tumor cells expressing MAGE-A4. This results in cell death of MAGE-A4-expressing tumor cells. The tumor-associated antigen (TAA) MAGE-A4, a member of the MAGE-A family of cancer testis antigens, is overexpressed by a variety of cancer cell types.	Autologous Genetically-modified MAGE-A4 C1032 T Cells | therapeutic_agents	C1909	therapeutic_agents
A	C177537	GDC Value Terminology	C177574	Coal Dust Exposure	Environmental or occupational exposure to dust derived during the processing of coal.	Coal Dust | exposure_type || Coal Gas, Coal Tar, Coal Tar Pitch, and Derivatives | chemical_exposure_type	C157103 || C198092	exposure_type || chemical_exposure_type
A	C177537	GDC Value Terminology	C177681	Gene Amplification Negative	An indication that amplification of one or more genes of interest was not detected in a sample.	Not Amplified | test_result	C36292	test_result
A	C177537	GDC Value Terminology	C177682	Gene Amplification Positive	An indication that amplification of one or more genes of interest was detected in a sample.	Amplified | test_result	C36292	test_result
A	C177537	GDC Value Terminology	C177693	Elevated Expression	An indication that the expression of a gene, transcript or protein is higher than a previous value or a normal range of values.	Overexpressed | test_result	C36292	test_result
A	C177537	GDC Value Terminology	C185298	Measurable Residual Disease Assessment	An examination for minimal residual disease status.	Minimal Residual Disease | laboratory_test	C25294	laboratory_test
A	C177537	GDC Value Terminology	C186534	Embryonal Tumor with Multilayered Rosettes	A central nervous system embryonal tumor characterized by the presence of multilayered rosette formation and typically the presence of amplification of the C19MC region on chromosome 19 (19q13.42) or rarely a DICER1 mutation.	9478/3 | morphology || Embryonal tumor with multilayered rosettes, NOS | primary_diagnosis	C176985 || C177621	morphology || primary_diagnosis
A	C177537	GDC Value Terminology	C186612	AJCC Cancer Staging Manual 6th Edition	The 6th edition of the criteria developed by the American Joint Committee on Cancer (AJCC) and used for the classification and staging of neoplastic diseases. It was published in 2002 and was in effect 2003-2009.	6th | ajcc_staging_system_edition	C177561	ajcc_staging_system_edition
A	C177537	GDC Value Terminology	C189768	Smokeless Tobacco Exposure	Environmental, occupational, or consumer-based exposure to any smokeless tobacco product.	Smokeless Tobacco | exposure_type	C157103	exposure_type
A	C177537	GDC Value Terminology	C190189	TAR Format	A file format generated by the Unix command-line utility tar (tape archive). It is used for collecting many files into one archive file.	TAR | data_format	C42761	data_format
A	C177537	GDC Value Terminology	C191343	AJCC Cancer Staging Manual 4th Edition	AJCC Manual for Staging of Cancer 4th Edition (AJCC V4) (Beahrs OH, Henson DE, Hutter RVP, Kennedy BJ, editors. AJCC manual for staging of cancer (4th ed). Philadelphia, PA: J.B. Lippincott; 1992). No part of the AJCC V4 may be reproduced, distributed, or transmitted in any form or by any means, including photocopying, recording, or other electronic or mechanical methods, without the prior written permission of Springer and payment of any applicable fees. Copyright J.B. Lippincott Company 1992. All rights reserved.	4th | ajcc_staging_system_edition	C177561	ajcc_staging_system_edition
A	C177537	GDC Value Terminology	C191344	AJCC Cancer Staging Manual 5th Edition	AJCC Cancer Staging Manual 5th Edition (AJCC V5) (Fleming ID, Cooper JS, Henson DE, Hutter RVP, Kennedy BJ, Murphy GP, O'Sullivan B, Sobin LH, Yarbo JW, editors. AJCC cancer staging manual (5th ed). Philadelphia, PA: Lippincott-Raven; 1997). No part of the AJCC V5 may be reproduced, distributed, or transmitted in any form or by any means, including photocopying, recording, or other electronic or mechanical methods, without the prior written permission of Springer and payment of any applicable fees. Copyright Lippincott-Raven 1997. All rights reserved.	5th | ajcc_staging_system_edition	C177561	ajcc_staging_system_edition
A	C177537	GDC Value Terminology	C198584	Iodine I 131 Radiation Therapy	Radiation Therapy that uses iodine I-131. It is typically used to treat thyroid conditions.	I-131 Radiation Therapy | treatment_type	C25218	treatment_type
A	C177537	GDC Value Terminology	C198715	Administration Professional	Occupations held by individuals who analyze management and organization, administer and develop policies, handle human resources and train and develop staff.	Administration Professionals | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198716	Administrative and Specialized Secretary	Occupations held by secretaries who perform administrative duties in the office, and may have specialized knowledge in other professions, such as legal or medical.	Administrative and Specialized Secretaries | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198717	Animal Producer	Occupations held by individuals who work to propagate species of animals.	Animal Producers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198718	Architect, Planner, Surveyor and Designer	Occupations held by individuals who plan and design landscapes, building exteriors and interiors, products for manufacture and visual and audiovisual content for the communication of information.	Architects, Planners, Surveyors and Designers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198719	Armed Forces Occupation, Other Rank	Occupations held by individuals who are part of a community dedicated to protect a geographic location.	Armed Forces Occupations, Other Ranks | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198720	Artistic, Cultural and Culinary Associate Professional	Occupations held by individuals who combine creative skills and technical and cultural knowledge in taking and processing still photographs; design and decoration of theater sets, shop displays and the interiors of homes; preparation of objects for display; maintenance of library and gallery collections, records and cataloging systems; creation of menus and preparation and presentation of food; provision of support for stage, film and television production; and in other areas of artistic and cultural endeavor.	Artistic, Cultural and Culinary Associate Professionals | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198721	Assembler	Occupations held by individuals who assemble prefabricated parts of components to form subassemblies, products and equipment.	Assemblers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198722	Author, Journalist and Linguist	Occupations held by individuals who conceive and create literary works; interpret and communicate news and public affairs through the medial and translate or interpret from one language into another.	Authors, Journalists and Linguists | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198723	Blacksmith, Toolmaker and Related Trades Worker	Occupations held by individuals who hammer and forge bars, rods or ingots of iron, steel and other metals to make and repair various kinds of tools, equipment and other articles; set machine tools for operators, or set and operate various machine tools; and polish and sharpen surfaces.	Blacksmiths, Toolmakers and Related Trades Workers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198724	Building and Housekeeping Supervisor	Occupations held by individuals who build houses, lay bricks, work stone, place concrete, carpenters and joiners.	Building and Housekeeping Supervisors | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198725	Building Finisher and Related Trades Worker	Occupations held by individuals who put the finishing touches on buildings and the trades related to such activities.	Building Finishers and Related Trades Workers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198726	Building Frame and Related Trades Worker	Occupations held by individuals who lay roofing material, put down floors and set tiles, plaster, insulate, glaze, plumb and pipe fit and work on air conditioning and refrigeration.	Building Frame and Related Trades Workers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198727	Business Services Agent	Occupations held by individuals who establish contacts to sell various business services such as advertising space in the media, carry out customs clearance activities, match jobseekers; find workers for employers; arrange contracts or the performance of athletes, entertainers and artists, as well as for the publication of books, the production of plays, or the recording, performance and sale of music; and plan and organize conferences and similar events.	Business Services Agents | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198728	Business Services and Administration Manager	Occupations held by individuals who manage finance, human resources, and policy and planning.	Business Services and Administration Managers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198729	Car, Van and Motorcycle Driver	Occupations held by individuals who drive and tend motorcycles, motorized tricycles, cars or vans to transport passengers, materials or goods.	Car, Van and Motorcycle Drivers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198730	Cashier and Ticket Clerk	Occupations held by individuals who operate cash registers, optical price scanners, computers or other equipment to record and accept payment for the purchase of goods, services and admissions in settings such as stores, restaurants and ticket offices.	Cashiers and Ticket Clerks | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198731	Chemical and Photographic Products Plant and Machine Operator	Occupations held by individuals who monitor and operate machines which process a variety of chemicals and other ingredients to produce pharmaceuticals, toiletries, explosives and photographic or other chemical products.	Chemical and Photographic Products Plant and Machine Operators | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198732	Child Care Worker and Teachers' Aide	Occupations held by individuals who tend to the care of children and assist teachers.	Child Care Workers and Teachers' Aides | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198733	Client Information Worker	Occupations held by individuals who advise in the context of travel consulting, contact center information, telephone switchboard operators, hotel receptionists, inquiry clerks, general receptionists and survey and market research interviewers.	Client Information Workers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198734	Commissioned Armed Forces Officer	Occupations held by individuals who have received a commission in the armed forces military. They provide leadership and management to organizational units in the armed forces and/or perform similar tasks to those performed in a variety of civilian occupations outside the armed forces.	Commissioned Armed Forces Officers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198735	Database and Network Professional	Occupations held by individuals who design and administrate databases, systems administrators and computer network professionals.	Database and Network Professionals | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198736	Domestic, Hotel and Office Cleaner and Helper	Occupations held by individuals who clean in the home, hotel or office environment.	Domestic, Hotel and Office Cleaners and Helpers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198737	Electronics and Telecommunications Installer and Repairer	Workers who install, repair, or replace a variety of electrical equipment in telecommunications, transportation, utilities, and other industries.	Electronics and Telecommunications Installers and Repairers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198738	Electrotechnology Engineer	Occupations held by individuals who conduct research on and design, advise, plan and direct the construction and operation of electronic, electrical and telecommunications systems, components, motors and equipment.	Electrotechnology Engineers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198739	Financial and Mathematical Associate Professional	Occupations held by individuals who are securities and finance dealers and brokers, credit and loan officers, accounting associate professionals, statistical, math and related associate professionals, valuers and assessors.	Financial and Mathematical Associate Professionals | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198740	Fishery Worker, Hunter and Trapper	Workers who gather fish or other aquatic animals for human consumption or other uses and/or hunt and trap wild animals for human consumption, fur, feed, bait, or other purposes.	Fishery Workers, Hunters and Trappers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198741	Food and Related Products Machine Operator	Occupations held by individuals who are butchers, fishmongers, and related food preparers bakers, pastry-cooks and confectionery makers; dairy products makers; fruit, vegetable and related preservers, food and beverage tasters and graders, tobacco preparers, and tobacco products makers.	Food and Related Products Machine Operators | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198742	Food Preparation Assistant	Occupations held by individuals who set, operate and attend machinery used to slaughter animals and trim meat from carcasses, and to bake, freeze, heat, crush, mix, blend and otherwise process foodstuffs, beverages and tobacco leaves.	Food Preparation Assistants | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198743	Food Processing and Related Trades Worker	Workers who prepare, season, and cook foods, as well as workers who perform routine tasks under the direction of cooks, chefs, or food service managers.	Food Processing and Related Trades Workers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198744	Forestry and Related Worker	Occupations held by individuals who plan, organize and perform operations to cultivate, conserve and exploit natural and plantation forests.	Forestry and Related Workers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198745	Garment and Related Trades Worker	Occupations held by individuals who are tailors, dressmakers, furriers, hatters; garment and related patternmakers and cutters; sewing, embroidery and related workers; upholsterers and related workers; pelt dressers, tanners and fellmongers; and shoemakers and related workers.	Garment and Related Trades Workers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198746	General Office Clerk	Occupations held by individuals who perform a range of clerical and administrative tasks according to established procedures.	General Office Clerks | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198747	Government Regulatory Associate Professional	Occupations held by individuals who work in customs and border inspectors, government tax and excise officials, government social benefits, government licensing, police inspectors and detectives, government regulatory associate professionals.	Government Regulatory Associate Professionals | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198748	Hairdresser, Beautician and Related Worker	Occupations held by individuals who cut and dress hair, shave and trim beards, give beauty treatments, apply cosmetics and make-up and give other kinds of treatment to individuals in order to improve their appearance.	Hairdressers, Beauticians and Related Workers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198749	Handicraft Worker	Occupations that rely upon use of the hands, including precision instrument or musical instrument makers and repairers, jewelry makers, potters, signmakers and painters, and workers in wood, textiles, and related materials.	Handicraft Workers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198750	Heavy Truck and Bus Driver	Occupations that include driving heavy vehicles such as large buses and trucks.	Heavy Truck and Bus Drivers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198751	Hotel and Restaurant Manager	Occupations that comprise hotel and restaurant managers.	Hotel and Restaurant Managers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198752	Information and Communications Technology Operations and User Support Technician	Information and communications occupations that include technicians and operators of computer networks, computer systems, internet systems.	Information and Communications Technology Operations and User Support Technicians | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198753	Information and Communications Technology Service Manager	Workers who supervise the technicians and operators of computer networks, computer systems, internet systems.	Information and Communications Technology Service managers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198754	Keyboard Operator	Clerical support workers that input and process text and data, and prepare, edit and generate documents for storage, processing, publication and transmission.	Keyboard Operators | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198755	Legislator and Senior Official	Government workers who determine, formulate, advise on and direct the implementation of policies of national, state, regional, or local governments or communities, and of special interest organizations.	Legislators and Senior Officials | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198756	Life Science Technician and Related Associate Professional	Technicians and other associates who perform technical tasks connected with research and operations in life sciences, which includes biology, botany, biochemistry, agriculture, and forestry.	Life Science Technicians and Related Associate Professionals | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198757	Locomotive Engine Driver and Related Worker	The occupations consisting of locomotive drivers and railway brake, signal, and switch operators.	Locomotive Engine Drivers and Related Workers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198758	Machinery Mechanics and Repairer	Occupations involved with the maintenance or repair of machinery.	Machinery Mechanics and Repairers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198759	Managing Director and Chief Executive	Individuals that formulate and review the policies, and plan, direct, coordinate, and evaluate the overall activities of enterprises or organizations, with the support of other managers, usually within guidelines established by a board of directors or a governing body.	Managing Directors and Chief Executives | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198760	Manufacturing, Mining, Construction and Distribution Manager	A manager in charge of manufacturing, mining, or construction and distribution workers.	Manufacturing, Mining, Construction and Distribution Managers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198761	Market Gardener and Crop Grower	Gardeners or growers that raise crops for market.	Market Gardeners and Crop Growers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198762	Material Recording and Transport Clerk	A clerk for material recording or shipment and receiving of goods.	Material Recording and Transport Clerks | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198763	Mathematician, Actuary and Statistician	Mathematicians doing actuarial or statistical work.	Mathematicians, Actuaries and Statisticians | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198764	Medical and Pharmaceutical Technician	Technicians in medical or pharmaceutical fields.	Medical and Pharmaceutical Technicians | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198765	Metal Processing and Finishing Plant Operator	An operator in charge of a metal processor or finishing plant machine.	Metal Processing and Finishing Plant Operators | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198766	Mining and Construction Laborer	Individuals who do hands-on work in mining or construction.	Mining and Construction Labourers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198767	Mining and Mineral Processing Plant Operator	An operator in charge of a mining or mineral processing plant machine.	Mining and Mineral Processing Plant Operators | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198768	Mining, Manufacturing and Construction Supervisor	Workers who directly supervise and coordinate the activities of mining, manufacturing, or construction workers.	Mining, Manufacturing and Construction Supervisors | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198769	Mixed Crop and Animal Producer	Workers who plan, organize and perform farming operations to breed and raise domesticated or non-domesticated animals for meat or animal products or farmers raising mixed crops.	Mixed Crop and Animal Producers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198770	Mobile Plant Operator	Operators that drive backhoes, bulldozers, excavators, front- end loaders, graders, scrapers, skid-steer loaders, rollers and forklift trucks to level, excavate, move and load earth, rock and other material.	Mobile Plant Operators | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198771	Non-commissioned Armed Forces Officer	A military enlistee who has achieved sergeant, or equivalent rank.	Non-commissioned Armed Forces Officers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198772	Numerical Clerk	Clerks who do accounting, bookkeeping, statistical, financial, and other numerical data, and take charge of cash transactions incidental to business matters.	Numerical Clerks | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198773	Nursing and Midwifery Associate Professional	Occupations held by individuals who give assistance in basic nursing and personal care for people who are physically or mentally ill, disabled or infirm, and others in need of care due to potential risks to health including before, during and after childbirth. They generally work under the supervision of, and in support of implementation of health care, treatment and referrals plans established by, medical, nursing, midwifery and other health professionals.	Nursing and Midwifery Associate Professionals | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198774	Nursing and Midwifery Professional	Occupations held by individuals who plan, provide or manage basic nursing and personal care for people who are physically or mentally ill, disabled or infirm, and others in need of care due to potential risks to health including before, during and after childbirth. This includes delivery of infants and planning, providing, and managing prenatal and postpartum care, newborn care, and some routine care (such as gynecological exams) for women.	Nursing and Midwifery Professionals | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198775	Other Clerical Support Worker	A clerical support worker not otherwise listed.	Other Clerical Support Workers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198776	Other Craft and Related Worker	A craft and related worker not otherwise listed.	Other Craft and Related Workers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198777	Other Elementary Worker	An elementary worker not otherwise listed.	Other Elementary Workers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198778	Other Health Associate Professional	A health associate professional not otherwise listed.	Other Health Associate Professionals | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198779	Other Health Professional	A health professional not otherwise listed.	Other Health Professionals | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198780	Other Personal Services Worker	A personal service worker not otherwise listed.	Other Personal Services Workers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198781	Other Services Manager	A service manager not otherwise listed.	Other Services Managers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198782	Other Stationary Plant and Machine Operator	A stationary plant or machine operator not otherwise listed.	Other Stationary Plant and Machine Operators | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198783	Painter, Building Structure Cleaner and Related Trades Worker	Occupations held by individuals who prepare the outer surfaces or interiors of buildings, vehicles or other structures or large manufactured articles and apply paint, wallpaper or fabric, and those who clean exterior surfaces, chimneys and other structures associated with buildings.	Painters, Building Structure Cleaners and Related Trades Workers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198784	Personal Care Workers in Health Service	Occupations held by individuals who provide personal care, mobility assistance and help with daily activities to patients, elderly or disabled individuals in health care and residential settings.	Personal Care Workers in Health Services | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198785	Physical and Earth Science Professional	Occupations held by individuals who do research and contribute to the development of concepts, theories, methods and applications of physical sciences, including astronomy, chemistry, geology, meteorology and physics.	Physical and Earth Science Professionals | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198786	Physical and Engineering Science Technician	Occupations held by individuals who aid in the research and applications of physical science principles in engineering, technical drawing and manufacturing.	Physical and Engineering Science Technicians | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198787	Primary School and Early Childhood Teacher	Occupations held by individuals who teach a range of subjects at the primary educational level and those who organize educational activities for children younger than primary school age.	Primary School and Early Childhood Teachers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198788	Process Control Technician	Occupations held by individuals who manage, operate and or maintain equipment and machinery used in complex processes including, electrical power production, waste and water management and treatment, chemical manufacturing, and refining of petroleum, natural gas and metals.	Process Control Technicians | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198789	Production Manager in Agriculture, Forestry and Fishery	Occupations held by individuals who plan, direct and coordinate productivity of large-scale agricultural, horticultural, forestry, aquacultural and fishery operations.	Production Managers in Agriculture, Forestry and Fisheries | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198790	Professional Services Manager	Occupations held by individuals who plan, direct and coordinate the provision of social care services (child care, health care, welfare and educational services) and other professional services, and those who are branch managers for institutions that provide financial and insurance services.	Professional Services Managers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198791	Refuse Worker	Occupations held by individuals who collect, sort, process and recycle garbage from various locations or those that keep streets, parks or other public spaces clean.	Refuse Workers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198792	Retail and Wholesale Trade Manager	Occupations held by individuals who plan, organize and coordinate the operations for retail and wholesale establishments that sell goods.	Retail and Wholesale Trade Managers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198793	Rubber, Plastic and Paper Products Machine Operator	Occupations held by individuals who operate and monitor machines that blend natural or synthetic rubber compounds and various components to produce various rubber-containing products including the manufacture of composite goods that also include plastic or paper components.	Rubber, Plastic and Paper Products Machine Operators | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198794	Sales and Purchasing Agent and Broker	Occupations held by individuals who represent companies, governments or other organizations that buy and sell commodities, goods or insurance or provide shipping and other services to other establishments.	Sales and Purchasing Agents and Brokers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198795	Sales, Marketing and Development Manager	Occupations held by individuals who plan and manage public relations, sales, marketing and research and development activities for goods and services provided by companies or organizations.	Sales, Marketing and Development Managers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198796	Sales, Marketing and Public Relations Professional	Occupations held by individuals who plan develop, coordinate and implement programs to disseminate information related to organizations, companies, goods or services, and those who promote marketing and sales of goods and services.	Sales, Marketing and Public Relations Professionals | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198797	Secondary Education Teacher	Occupations held by individuals who teach one or more subjects at the secondary education level, excluding vocational/occupational subjects.	Secondary Education Teachers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198798	Secretary (General)	Occupations held by individuals who provide a range of administrative support services. This may include use of word processing equipment to transcribe and format correspondence, dictated or draft minutes and reports and other documents to conform to business rules, handling of incoming and outgoing mail and other correspondence, organizing and filing of documents, and surveying and recording of requests for meetings, appointments and staff leave.	Secretaries (general) | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198799	Sheet and Structural Metal Worker, Molder and Welder, and Related Worker	Occupations held by individuals who make molds and cores for casting metal, those who cast, weld, shape or repair metals or objects made of metals (such as sheet metals), and those who install, construct, maintain and repair heavy metal-containing structures and equipment.	Sheet and Structural Metal Workers, Moulders and Welders, and Related Workers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198800	Ship and Aircraft Controller and Technician	Occupations held by individuals who manage the operation of all equipment used on board a ship, boat or aircraft, those who command, pilot, navigate, control and/or direct the movement of ships, boats or aircraft, and those who develop and maintain navigation systems for ships, boats or aircraft and air traffic control systems.	Ship and Aircraft Controllers and Technicians | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198801	Ships' Deck Crew and Related Worker	Occupations held by individuals who carry out duties associated with being on board ships and other watercraft.	Ships' Deck Crews and Related Workers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198802	Social and Religious Professional	Occupations held by individuals who research, analyze, improve or develop theories regarding historical and current events, those who apply solutions to philosophical, political, economic and social problems and those who provide social services to meet the needs of individuals or families in the community.	Social and Religious Professionals | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198803	Software and Applications Developer and Analyst	Occupations held by individuals who research, plan, design, write, test, improve, analyze or set requirements for technology systems and their components, which includes hardware, software and other applications.	Software and Applications Developers and Analysts | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198804	Sports and Fitness Worker	Occupations held by individuals who provide instruction and promote participation in exercise, sports and other recreational activities, those who train for and compete in sporting events, those who provide performance enhancement training and/or coaching for those participating in sports, and those who organize and officiate sporting events.	Sports and Fitness Workers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198805	Street and Market Salesperson	Occupations held by individuals who are permitted to sell goods or prepare and sell hot or cold food and beverages from stalls in public places such as streets or markets.	Street and Market Salespersons | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198806	Street and Related Service Worker	Occupations held by individuals who provide on the spot services in public places including shoe, car and windshield cleaning, running errands and handing out leaflets or other publications.	Street and Related Service Workers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198807	Street Vendor (Excluding Food)	Occupations held by individuals who sell goods and products (excluding food) in streets and public places or by going house to house.	Street Vendors (excluding Food) | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198808	Subsistence Crop Farmer	Occupations held by individuals who grow and harvest field-grown crops and edible products from other plants to provide food and shelter for themselves and their family and, in some cases, acquire a minimum level of income for the household.	Subsistence Crop Farmers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198809	Subsistence Fisherman, Hunter, Trapper and Gatherer	Occupations held by individuals who gather wild plants for food or medicinal purposes, hunt and trap animals, and catch fish and other aquatic animals to provide food and shelter for themselves and their family and, in some cases, acquire a minimum level of income for the household.	Subsistence Fishers, Hunters, Trappers and Gatherers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198810	Subsistence Livestock Farmer	Occupations held by individuals who breed, raise and tend livestock to provide food and shelter for themselves and their family and, in some cases, acquire a minimum level of income for the household.	Subsistence Livestock Farmers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198811	Subsistence Mixed Crop and Livestock Farmer	Occupations held by individuals who breed, raise and tend livestock and who grow and harvest field-grown crops and edible products from other plants to provide food and shelter for themselves and their family and, in some cases, acquire a minimum level of income for the household.	Subsistence Mixed Crop and Livestock Farmers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198812	Telecommunications and Broadcasting Technician	Occupations held by individuals who ensure all technical equipment for recording, editing and transmission of radio and television broadcasts or other telecommunication signals remains functional. This also includes those who design, develop and perform research for telecommunication systems.	Telecommunications and Broadcasting Technicians | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198813	Textile, Fur and Leather Products Machine Operator	Occupations held by individuals who operate machinery to prepare, process and chemically treat raw textiles, leather and fur products, those who process yarn or thread to manufacture fabrics, and those who use machines to process textiles, leather, fur, yarn, thread or fabrics in the production or repair of items such as: footwear, baggage, rugs/carpets, handbags or garments.	Textile, Fur and Leather Products Machine Operators | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198814	Traditional and Complementary Medicine Associate Professional	Occupations held by individuals who assist in the providence of health care-related services based on traditional and/or complementary medical practices.	Traditional and Complementary Medicine Associate Professionals | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198815	Traditional and Complementary Medicine Professional	Occupations held by individuals who provide health care-related services based on traditional and/or complementary medical practices.	Traditional and Complementary Medicine Professionals | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198816	Transport and Storage Laborer	Occupations held by individuals who operate and drive vehicles to transport passengers, goods and or freight, those who pack, carry, load and hand deliver goods and freight, and those who stock shelves.	Transport and Storage Labourers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198817	Travel Attendant, Conductor and Guide	Occupations held by individuals who provide services in connection with travel or tours/excursions. The services may include provision of information for and during travel, and the collection or issuance of tickets to, ensuring safety of, and serving of food/refreshments to passengers.	Travel Attendants, Conductors and Guides | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198818	Vehicle, Window, Laundry and Other Hand Cleaning Worker	Occupations held by individuals who clean windows, building surfaces, vehicles or textiles by hand.	Vehicle, Window, Laundry and Other Hand Cleaning Workers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198819	Vocational Education Teacher	Occupations held by individuals who teach or provide instruction in vocational or occupational subjects to adults and senior students in secondary schools, colleges and institutions of further education.	Vocational education teachers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198820	Wood Processing and Papermaking Plant Operator	Occupations held by individuals who operate machinery to produce products from raw lumber including wood veneer, plywood, pulp and paper.	Wood Processing and Papermaking Plant Operators | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198821	Wood Treater, Cabinet-maker and Related Trades Worker	Occupations held by individuals who are involved in the preservation and treatment of wood, in the construction, decoration and repair of wooden furniture and other wooden products, and in the assembly, operation and maintenance of woodworking machines and tools.	Wood Treaters, Cabinet-makers and Related Trades Workers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198822	Legal, Social and Religious Associate Professional	Professionals who provide technical and practical services and support functions in legal processes and investigations, social and community assistance programs, and religious activities.	Legal, Social and Religious Associate Professionals | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C198920	Concordant Bone Marrow Histology	A finding, usually associated with lymphoma with bone marrow involvement, where the morphology observed in the bone marrow is the same as that found in the primary nodal site.	Bone marrow concordant histology | additional_pathology_findings	C158809	additional_pathology_findings
A	C177537	GDC Value Terminology	C198921	Discordant Bone Marrow Histology	A finding, usually associated with lymphoma with bone marrow involvement, where the morphology observed in the bone marrow is different from that found in the primary nodal site.	Bone marrow discordant histology | additional_pathology_findings	C158809	additional_pathology_findings
A	C177537	GDC Value Terminology	C198923	Daily Drinker	An individual who drinks one or more alcoholic beverages each day.	Daily Drinker | alcohol_frequency	C188000	alcohol_frequency
A	C177537	GDC Value Terminology	C198924	Weekly Drinker	An individual who drinks alcoholic beverages once a week.	Weekly Drinker | alcohol_frequency	C188000	alcohol_frequency
A	C177537	GDC Value Terminology	C198925	Agent Orange Exposure	A finding indicating that an individual has been exposed to the herbicide agent orange.	Agent Orange | chemical_exposure_type	C198092	chemical_exposure_type
A	C177537	GDC Value Terminology	C198926	Aluminum Exposure	A finding indicating that an individual has been exposed to aluminum or aluminum-containing compounds.	Aluminum | chemical_exposure_type	C198092	chemical_exposure_type
A	C177537	GDC Value Terminology	C198927	Cadmium Exposure	A finding indicating that an individual has been exposed to cadmium or cadmium-containing compounds.	Cadmium | chemical_exposure_type	C198092	chemical_exposure_type
A	C177537	GDC Value Terminology	C198934	Chromium Exposure	A finding indicating that an individual has been exposed to chromium or chromium-containing compounds.	Chromium | chemical_exposure_type	C198092	chemical_exposure_type
A	C177537	GDC Value Terminology	C198935	Copper Exposure	A finding indicating that an individual has been exposed to copper or copper-containing compounds.	Copper | chemical_exposure_type	C198092	chemical_exposure_type
A	C177537	GDC Value Terminology	C198936	Diesel Exhaust Exposure	Environmental, occupational, or consumer-based exposure to volatiles and particulates present in diesel exhaust.	Diesel Exhaust | chemical_exposure_type	C198092	chemical_exposure_type
A	C177537	GDC Value Terminology	C198937	Disinfectant Exposure	Environmental, occupational, or consumer-based exposure to epoxy compounds and other volatile chemicals associated with production, handling and use of disinfectants.	Disinfectant | chemical_exposure_type	C198092	chemical_exposure_type
A	C177537	GDC Value Terminology	C198938	Formaldehyde Exposure	A finding indicating that an individual has been exposed to formaldehyde.	Formaldehyde | chemical_exposure_type	C198092	chemical_exposure_type
A	C177537	GDC Value Terminology	C198939	Methylene Chloride Exposure	A finding indicating that an individual has been exposed to methylene chloride.	Methylene Chloride | chemical_exposure_type	C198092	chemical_exposure_type
A	C177537	GDC Value Terminology	C198940	Crude Oil Exposure	Environmental, occupational, or consumer-based exposure to volatiles derived from the organic compounds and polycyclic aromatic hydrocarbons and particulates that are present in crude oil.	Oil | chemical_exposure_type	C198092	chemical_exposure_type
A	C177537	GDC Value Terminology	C198941	Pesticide Exposure	Environmental, occupational, or consumer-based exposure to pesticides.	Pesticide | chemical_exposure_type	C198092	chemical_exposure_type
A	C177537	GDC Value Terminology	C198942	Petroleum Hydrocarbon Compound Exposure	Environmental, occupational, or consumer-based exposure to the volatile organic compounds and polycyclic aromatic hydrocarbons that are present in and produced during refinement of petroleum products.	Petroleum Hydrocarbon Compound | chemical_exposure_type	C198092	chemical_exposure_type
A	C177537	GDC Value Terminology	C198943	Resin Fume Exposure	Environmental, occupational, or consumer-based exposure epoxy compounds and other volatile chemicals associated with production and handling of resins (liquid plastics).	Resin Fumes | chemical_exposure_type	C198092	chemical_exposure_type
A	C177537	GDC Value Terminology	C198944	Sodium Borate Exposure	A finding indicating that an individual has been exposed to sodium borate.	Sodium Borate | chemical_exposure_type	C198092	chemical_exposure_type
A	C177537	GDC Value Terminology	C198945	Solvent Exposure	Environmental, occupational, or consumer-based exposure to volatiles associated with production, handling and use of chemical solvents.	Solvent | chemical_exposure_type	C198092	chemical_exposure_type
A	C177537	GDC Value Terminology	C198946	Tetrachloroethylene Exposure	A finding indicating that an individual has been exposed to tetrachloroethylene.	Tetrachloroethylene | chemical_exposure_type	C198092	chemical_exposure_type
A	C177537	GDC Value Terminology	C198947	Toluene Exposure	A finding indicating that an individual has been exposed to toluene or toluene-containing compounds.	Toluene | chemical_exposure_type	C198092	chemical_exposure_type
A	C177537	GDC Value Terminology	C198952	Short Arm of Chromosome	The shorter arm of the chromosome based on the distance from the most distal point to the centromere.	p | chromosome_arm	C13355	chromosome_arm
A	C177537	GDC Value Terminology	C198953	Long Arm of Chromosome	The longer arm of the chromosome based on the distance from the most distal point to the centromere.	q | chromosome_arm	C13355	chromosome_arm
A	C177537	GDC Value Terminology	C198955	Intermediate Analysis Archive	A preserved or historical dataset comprised of items used in or generated by preliminary or interim data analysis processes.	Intermediate Analysis Archive | data_type	C172272	data_type
A	C177537	GDC Value Terminology	C198967	Extensive Extracapsular Extention	A morphological finding indicating that the tumor cell invasion outside the lymph node capsule was greater than 1 mm.	Extensive | extracapsular_extension	C198101	extracapsular_extension
A	C177537	GDC Value Terminology	C198968	Focal Extracapsular Extention	A morphological finding indicating that the tumor cell invasion outside the lymph node capsule was less than or equal to 1 mm.	Focal | extracapsular_extension	C198101	extracapsular_extension
A	C177537	GDC Value Terminology	C198969	Gross Extranodal Extension	An indication that the lymph node metastases of a malignant neoplasm have invaded adjacent organs.	Gross Extension | extranodal_extension	C160837	extranodal_extension
A	C177537	GDC Value Terminology	C198970	Microscopic Extranodal Extension	An indication that extension of a malignant neoplasm beyond the lymph node was less than or equal to 2 mm.	Microscopic Extension | extranodal_extension	C160837	extranodal_extension
A	C177537	GDC Value Terminology	C198972	Personal History of Colorectal Cancer	An individual history of colorectal cancer.	Colorectal Cancer | history_of_tumor_type	C185074	history_of_tumor_type
A	C177537	GDC Value Terminology	C198973	Personal History of Low Grade Glioma	An individual history of low grade glioma.	Lower Grade Glioma | history_of_tumor_type	C185074	history_of_tumor_type
A	C177537	GDC Value Terminology	C198980	Internal Tandem Duplication Mutation	The duplication of adjacent coding regions or whole exon sequences that are reinserted in-frame within the gene of origin.	Internal Tandem Duplication | variant_type	C173544	variant_type
A	C177537	GDC Value Terminology	C198983	Tumor Markers Normalized	The levels of expression of tumor markers has decreased to non-disease levels due to therapy.	Normalization of Tumor Markers | treatment_outcome	C18919	treatment_outcome
A	C177537	GDC Value Terminology	C198986	Mineralocorticoid Excess	A finding indicating that the concentration of mineralocorticoids in a sample is greater than normal values.	Mineralocorticoids Excess | risk_factors	C17103	risk_factors
A	C177537	GDC Value Terminology	C199151	Renal Involvement	A finding indicating the spread of disease to a kidney.	Kidney Involvement | imaging_findings	C199145	imaging_findings
A	C177537	GDC Value Terminology	C199154	Liver Involvement	A finding indicating the spread of disease to the liver.	Liver Involvement | imaging_findings	C199145	imaging_findings
A	C177537	GDC Value Terminology	C199155	Lung Involvement	A finding indicating the spread of disease to a lung.	Lung Involvement | imaging_findings	C199145	imaging_findings
A	C177537	GDC Value Terminology	C199157	Retroperitoneal Lymph Node Involvement	A finding indicating the spread of disease to a retroperitoneal lymph node.	Retroperitoneal Lymph Node Involvement | imaging_findings	C199145	imaging_findings
A	C177537	GDC Value Terminology	C199158	Vena Cava Involvement or Thrombus	A finding indicating a vena cava thrombus or other evidence of disease spread to the vena cava.	Vena Cava Involvement/Thrombus | imaging_findings	C199145	imaging_findings
A	C177537	GDC Value Terminology	C199161	Lesion with Diameter Greater than 20 mm	A semi-quantitative finding indicating that the largest diameter for a lesion is greater than 20 mm.	>20 mm | residual_tumor_measurement	C198194	residual_tumor_measurement
A	C177537	GDC Value Terminology	C199163	Lesion with Diameter at Least 1 mm and at Most 10 mm	A semi-quantitative finding indicating that the largest diameter for a lesion was at least 1 mm and at most 10 mm.	1-10 mm | residual_tumor_measurement	C198194	residual_tumor_measurement
A	C177537	GDC Value Terminology	C199164	Lesion with Diameter at Least 11 mm and at Most 20 mm	A semi-quantitative finding indicating that the largest diameter for a lesion was at least 11 mm and at most 20 mm.	11-20 mm | residual_tumor_measurement	C198194	residual_tumor_measurement
A	C177537	GDC Value Terminology	C199165	Macroscopic Disease Negative	An indication that macroscopic evidence of disease was not detected.	No macroscopic disease | residual_tumor_measurement	C198194	residual_tumor_measurement
A	C177537	GDC Value Terminology	C199177	Biochemical Assessment Indicator	An indication that a finding or diagnosis was assigned based on biochemical test results.	Biochemical Assessment | risk_factor_method_of_diagnosis	C198195	risk_factor_method_of_diagnosis
A	C177537	GDC Value Terminology	C199178	Clinical Assessment Indicator	An indication that a finding or diagnosis was assigned based on clinical observations.	Clinical Assessment | risk_factor_method_of_diagnosis	C198195	risk_factor_method_of_diagnosis
A	C177537	GDC Value Terminology	C199179	Clinical and Biochemical Assessments Indicator	An indication that a finding or diagnosis was assigned based on both clinical observations and biochemical test results.	Both Clinical and Biochemical Assessments | risk_factor_method_of_diagnosis	C198195	risk_factor_method_of_diagnosis
A	C177537	GDC Value Terminology	C199216	Peripheral Blood Components	A specimen containing undefined components from peripheral blood collected from an experimental subject.	Peripheral Blood Components, NOS | specimen_type	C70713	specimen_type
A	C177537	GDC Value Terminology	C199218	Death without Remission	An indication that a subject died during treatment but had not achieved remission.	Death without Remission | first_event	C198107	first_event
A	C177537	GDC Value Terminology	C199314	Adulthood	A time period in the human lifespan when full physical and intellectual maturity have been attained, which generally follows adolescence.	Adulthood | timepoint_category	C198201	timepoint_category
A	C177537	GDC Value Terminology	C199315	Last Contact Event Occurrence Indicator	An indication that an individual has had their last contact event.	Last Contact | timepoint_category	C198201	timepoint_category
A	C177537	GDC Value Terminology	C199316	After Hormone Therapy	Relating to or occurring after hormone therapy.	Post Hormone Therapy | timepoint_category	C198201	timepoint_category
A	C177537	GDC Value Terminology	C199317	Pre-Diagnosis	Relating to or occurring before a diagnosis was received.	Prior to Diagnosis | timepoint_category	C198201	timepoint_category
A	C177537	GDC Value Terminology	C199318	End of Consolidation Therapy Occurrence Indicator	An indication that consolidation therapy has been completed.	End of Consolidation Therapy | timepoint_category	C198201	timepoint_category
A	C177537	GDC Value Terminology	C199319	End of Treatment Course Occurrence Indicator	An indication that a treatment course has been completed.	End of Treatment Course | timepoint_category	C198201	timepoint_category
A	C177537	GDC Value Terminology	C199320	End of Treatment Course 1 Occurrence Indicator	An indication that the first treatment course has been completed.	End of Treatment Course 1 | timepoint_category	C198201	timepoint_category
A	C177537	GDC Value Terminology	C199321	End of Treatment Course 2 Occurrence Indicator	An indication that the second treatment course has been completed.	End of Treatment Course 2 | timepoint_category	C198201	timepoint_category
A	C177537	GDC Value Terminology	C199322	First Complete Response Occurrence Indicator	An indication that the first observation of a complete disease response has occurred.	First Complete Response | timepoint_category	C198201	timepoint_category
A	C177537	GDC Value Terminology	C199323	Pre-Procurement	Relating to or occurring before obtaining goods, services, supplies, specimens, equipment or other required materials.	Prior to Procurement | timepoint_category	C198201	timepoint_category
A	C177537	GDC Value Terminology	C199324	Pre-Registration	Relating to or occurring before registration into a study or trial.	Prior to Study Registration | timepoint_category	C198201	timepoint_category
A	C177537	GDC Value Terminology	C199325	Four Tumor Grade Evaluation Tiers	Four clinical evidence tiers were present in the system used to evaluate the tumor grade for a subject.	Four Tier | tumor_grade_category	C198204	tumor_grade_category
A	C177537	GDC Value Terminology	C199326	Three Tumor Grade Evaluation Tiers	Three clinical evidence tiers were present in the system used to evaluate the tumor grade for a subject.	Three Tier | tumor_grade_category	C198204	tumor_grade_category
A	C177537	GDC Value Terminology	C199327	Presence of Clear Cytoplasm Less than or Equal to 25 Percent	A finding indicating that less than or equal to 25 percent of the cells in a sample have clear or vacuolated cytoplasm.	Cytoplasm presence <= to 25% | weiss_assessment_findings	C104015	weiss_assessment_findings
A	C177537	GDC Value Terminology	C199328	Tumor Capsule Invasion Present	A morphologic finding indicating that tumor cells have infiltrated the surrounding capsule of connective tissue and invaded nearby tissues.	Invasion of Tumor Capsule | weiss_assessment_findings	C104015	weiss_assessment_findings
A	C177537	GDC Value Terminology	C21481	First Degree Relative	Any relative who is one meiosis away from a particular individual in a family; a relative with whom one half of an individual's genes is shared (i.e., parent, sibling, offspring) (from Genetics Home Reference glossary)	First Degree Relative, NOS | relationship_type	C83393	relationship_type
A	C177537	GDC Value Terminology	C25260	Third	Following the second position in an ordering or series; coming next after the second and just before the fourth in position.	3rd | ajcc_staging_system_edition || 3rd | uicc_staging_system_edition	C177561 || C198206	ajcc_staging_system_edition || uicc_staging_system_edition
A	C177537	GDC Value Terminology	C25388	Local-Regional	Of or belonging to both a local and regional area of the body.	Locoregional | progression_or_recurrence_type || Locoregional Site | treatment_anatomic_site	C177640 || C70729	progression_or_recurrence_type || treatment_anatomic_site
A	C177537	GDC Value Terminology	C25392	Manufacturer	A person, enterprise, or entity that produces finished goods.	Manufacturing Labourers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C25499	Event	Something that happens at a given place and time.	Event | first_event	C198107	first_event
A	C177537	GDC Value Terminology	C25509	First	Preceding all others in time or space or degree.	1st | ajcc_staging_system_edition || 1st | uicc_staging_system_edition	C177561 || C198206	ajcc_staging_system_edition || uicc_staging_system_edition
A	C177537	GDC Value Terminology	C25666	Second	Coming next after the first in position in space or time or degree or magnitude.	2nd | ajcc_staging_system_edition || 2nd | uicc_staging_system_edition	C177561 || C198206	ajcc_staging_system_edition || uicc_staging_system_edition
A	C177537	GDC Value Terminology	C25741	Physician	A doctor; a person who has been educated, trained, and licensed to practice the art and science of medicine; a practitioner of medicine, as contrasted with a surgeon.	Medical Doctors | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C28006	Postoperative	Relating to or occurring during the period immediately following a surgical operation.	Postoperative | timepoint_category	C198201	timepoint_category
A	C177537	GDC Value Terminology	C28161	Intramuscular Route of Administration	Intramuscular injection is a route of drug administration via injection into muscle tissue. Aqueous or oleaginous solutions and emulsions or suspensions may be administered. Absorption rates, delay in availability of the drug to the systemic circulation, and duration of effect are perfusion-limited, depend on molecular size of the agent, volume, and osmolarity of the drug solution, fat content of the injection site, and patient physical activity.	Intramuscular | route_of_administration	C38114	route_of_administration
A	C177537	GDC Value Terminology	C2993	Down Syndrome	A chromosomal dysgenesis syndrome resulting from a triplication or translocation of chromosome 21. Down syndrome occurs in approximately 1:700 live births. Abnormalities are variable from individual to individual and may include mental retardation, retarded growth, flat hypoplastic face with short nose, prominent epicanthic skin folds, small low-set ears with prominent antihelix, fissured and thickened tongue, laxness of joint ligaments, pelvic dysplasia, broad hands and feet, stubby fingers, transverse palmar crease, lenticular opacities and heart disease. Patients with Down syndrome have an estimated 10 to 30-fold increased risk for leukemia; most have symptoms of Alzheimer's disease by age 40. Also known as trisomy 21 syndrome.	Down Syndrome | comorbidities || Down Syndrome | risk_factors	C16457 || C17103	comorbidities || risk_factors
A	C177537	GDC Value Terminology	C3101	Genetic Disorder	Genetic diseases are diseases in which inherited genes predispose to increased risk. The genetic disorders associated with cancer often result from an alteration or mutation in a single gene. The diseases range from rare dominant cancer family syndrome to familial tendencies in which low-penetrance genes may interact with other genes or environmental factors to induce cancer. Research may involve clinical, epidemiologic, and laboratory studies of persons, families, and populations at high risk of these disorders.	Inherited Genetic Syndrome, NOS | risk_factors	C17103	risk_factors
A	C177537	GDC Value Terminology	C3239	Monosomy	A chromosomal abnormality consisting of the absence of one chromosome from the normal diploid number.	Monosomy | aneuploidy	C2873	aneuploidy
A	C177537	GDC Value Terminology	C32671	Gastrosplenic Ligament	The portion of the greater omentum between the greater curvature of the stomach and the hilum of the spleen.	Gastrosplenic Ligament | sites_of_involvement	C173263	sites_of_involvement
A	C177537	GDC Value Terminology	C3421	Trisomy	A chromosomal abnormality consisting of the presence of one chromosome in addition to the normal diploid number.	Trisomy | aneuploidy	C2873	aneuploidy
A	C177537	GDC Value Terminology	C35064	Hereditary Hemorrhagic Telangiectasia	An autosomal dominant hereditary disorder caused by mutations in the ACVRL1, ENG, and SMAD4 genes. It is characterized by the presence of telangiectasias in the skin, mucous membranes, lungs, brain, liver, and gastrointestinal tract. It results in hemorrhages from the affected areas.	Hereditary Hemorrhagic Telangiectasia | risk_factors	C17103	risk_factors
A	C177537	GDC Value Terminology	C35903	Diffuse Pattern	A morphologic architectural pattern in which a cellular population is distributed in a relatively uniform fashion throughout a specified tissue area; not focal.	Diffuse Architecture | weiss_assessment_findings	C104015	weiss_assessment_findings
A	C177537	GDC Value Terminology	C35962	Atypical Mitotic Figures	A morphologic finding indicating the presence of atypical mitoses in malignant cells.	Atypical Mitotic Figures | weiss_assessment_findings	C104015	weiss_assessment_findings
A	C177537	GDC Value Terminology	C36184	Necrotic Change	A finding indicating the presence of cellular necrosis in a tissue specimen.	Necrosis | weiss_assessment_findings	C104015	weiss_assessment_findings
A	C177537	GDC Value Terminology	C36251	Benzene Exposure	Environmental, occupational or consumer-based exposure to benzene, benzene-containing compounds or benzene derivatives.	Benzene | chemical_exposure_type	C198092	chemical_exposure_type
A	C177537	GDC Value Terminology	C36370	t(9;11)(p21.3;q23.3)	A cytogenetic abnormality that refers to the translocation of the short arm (p21.3) of chromosome 9 and the long arm (q23.3) of chromosome 11. It is associated with the development of acute myeloid leukemia with the MLLT3-MLL fusion gene transcript.	t(9;11)(p22;q23) | chromosomal_translocation	C3420	chromosomal_translocation
A	C177537	GDC Value Terminology	C36371	t(11;19)(q23.3;p13.1)	A cytogenetic abnormality that refers to the translocation of the long arm (q23.3) of chromosome 11 and the short arm (p13.1) of chromosome 19. It is associated with the development of acute myeloid leukemia with variant MLL translocations and topoisomerase II inhibitor-related acute myeloid leukemia.	t(11;19)(q23;p13.1) | chromosomal_translocation	C3420	chromosomal_translocation
A	C177537	GDC Value Terminology	C36415	t(3;5)(q25;q34)	A cytogenetic abnormality that refers to the translocation of the long arm (q25) of chromosome 3 and the long arm (q34) of chromosome 5. It is associated with the development of acute myeloid leukemia arising from myelodysplastic syndrome, acute myeloid leukemia with multilineage dysplasia, and acute myeloid leukemia with myelodysplasia-related changes.	t(3;5)(q25;q34) | chromosomal_translocation	C3420	chromosomal_translocation
A	C177537	GDC Value Terminology	C36610	t(6;11)(q27;q23)	A cytogenetic abnormality that refers to the translocation of the long arm (q27) of chromosome 6 and the long arm (q23) of chromosome 11. It is associated with the development of de novo acute myeloid leukemia.	t(6;11)(q27;q23) | chromosomal_translocation	C3420	chromosomal_translocation
A	C177537	GDC Value Terminology	C38248	Intrahepatic Route of Administration	Intrahepatic route of drug administration is a method of drug delivery within the liver, predominantly via hepatic vein or artery. Regimen might be more beneficial then systemic one by delivering a higher dose of drug to the liver and reducing overall systemic exposure.	Intrahepatic | route_of_administration	C38114	route_of_administration
A	C177537	GDC Value Terminology	C38258	Intraperitoneal Route of Administration	Administration of a drug via injection or infusion of a substance into the peritoneum, where it is absorbed by the lining.	Intraperitoneal | route_of_administration	C38114	route_of_administration
A	C177537	GDC Value Terminology	C38269	Intratumoral Route of Administration	The administration of a drug within or introduced directly into a tumor. Method allows to achieve high concentration of the agent in the tumor and delay drug release in systemic circulation.	Intratumoral | route_of_administration	C38114	route_of_administration
A	C177537	GDC Value Terminology	C38278	Intravesical Route of Administration	The administration of a drug within the urinary bladder.	Intravesical | route_of_administration	C38114	route_of_administration
A	C177537	GDC Value Terminology	C38299	Subcutaneous Route of Administration	Drug administration beneath the skin. It provides for relatively slow, sustained release of the drug. The rate of absorption into the blood is perfusion-limited, proportional to the amount of drug at the site and can be enhanced by chemical or physical stimulation of blood flow. Subcutaneous administration minimizes the risks associated with intravascular injection: for subcutaneous infusions, external and implantable pumps are used.	Subcutaneous | route_of_administration	C38114	route_of_administration
A	C177537	GDC Value Terminology	C39298	Adolescence	A human life stage that begins at twelve years of age and continues until twenty-one complete years of age, generally marked by the beginning of puberty and lasting to the beginning of adulthood.	Adolescence | timepoint_category	C198201	timepoint_category
A	C177537	GDC Value Terminology	C39615	Sinusoidal Infiltration	A microscopic finding indicating the invasion of sinusoidal spaces by malignant cells.	Sinusoid Invasion | weiss_assessment_findings	C104015	weiss_assessment_findings
A	C177537	GDC Value Terminology	C39752	Refractory Disease	A disease that resists treatment.	Refractory Disease | initial_disease_status	C177616	initial_disease_status
A	C177537	GDC Value Terminology	C44456	Tobacco Smoke Related Exposure	Environmental, occupational, or consumer-based exposure to airborne gases and particulates produced by direct or nearby use of a vaporized or combusted tobacco product.	Tobacco smoke, NOS | type_of_smoke_exposure	C164057	type_of_smoke_exposure
A	C177537	GDC Value Terminology	C45576	Mutation Abnormality	Any transmissible change in the genetic material of an organism, which can result from radiation, viral infection, transposition, treatment with mutagenic chemicals and errors during DNA replication or meiosis. The effects of mutation range from single base changes to loss or gain of complete chromosomes. As many of the simpler alterations to DNA may be repaired, such changes are only heritable once the change is fixed in the DNA by the process of replication. Mutations may be associated with genetic diversity or with pathologies including cancer.	Mutation, NOS | variant_type	C173544	variant_type
A	C177537	GDC Value Terminology	C45584	Gene Fusion Abnormality	Fusion of two genes or segments of genes that were previously separated prior to a mutation abnormality such as translocation. A gene fusion abnormality results in the formation of a new genetic unit that typically exhibits altered functional characteristics. This type of mutation abnormality can be either heritable or occur somatically.	Fusion | variant_type	C173544	variant_type
A	C177537	GDC Value Terminology	C45792	First-Line Therapy	The preferred standard treatment for a particular condition.	First-Line Therapy | treatment_intent_type	C54398	treatment_intent_type
A	C177537	GDC Value Terminology	C47849	Venous Invasion	A term referring to the presence of tumor emboli or tumor masses within veins.	Venous Invasion | weiss_assessment_findings	C104015	weiss_assessment_findings
A	C177537	GDC Value Terminology	C51647	Distal Pancreatectomy	Surgical removal of the distal part of the pancreas.	Distal Pancreatectomy | treatment_type	C25218	treatment_type
A	C177537	GDC Value Terminology	C51759	Radical Neck Dissection	A surgical procedure in which all the ipsilateral cervical lymph node groups of the neck, internal jugular vein, sternocleidomastoid muscle, spinal accessory nerve, and submandibular gland are removed.	Radical Neck Dissection | lymph_node_dissection_method	C198458	lymph_node_dissection_method
A	C177537	GDC Value Terminology	C51904	Modified Radical Neck Dissection	A surgical procedure in which all the ipsilateral cervical lymph node groups of the neck are removed but the internal jugular vein, sternocleidomastoid muscle, and/or spinal accessory nerve are preserved.	Modified Radical Neck Dissection | lymph_node_dissection_method	C198458	lymph_node_dissection_method
A	C177537	GDC Value Terminology	C53420	Paramedic	An individual trained and certified to provide all basic and intermediate life support measures in addition to using invasive medical procedures (including intravenous therapy, cardiac defibrillation, administering medications and solutions, and using ventilation devices) as dictated by state law and performed under medical control in case of medical emergencies, hazardous materials exposure, child birth, abuse, fires, flood, accidents, trauma, and psychiatric crises.	Paramedical Practitioners | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C54007	More than 5 Mitoses per 50 HPF	A morphologic finding indicating the presence of more than five mitotic figures per fifty high power fields in a cellular infiltrate.	Mitotic Rate > 5/50 HPF | weiss_assessment_findings	C104015	weiss_assessment_findings
A	C177537	GDC Value Terminology	C54566	Fourth	Following the third position in an ordering or series; coming next after the third and just before the fifth in position.	4th | uicc_staging_system_edition	C198206	uicc_staging_system_edition
A	C177537	GDC Value Terminology	C54567	Fifth	Following the fourth position in an ordering or series; coming next after the fourth and just before the sixth in position.	5th | uicc_staging_system_edition	C198206	uicc_staging_system_edition
A	C177537	GDC Value Terminology	C54568	Sixth	Following the fifth position in an ordering or series; coming next after the fifth and just before the seventh in position.	6th | uicc_staging_system_edition	C198206	uicc_staging_system_edition
A	C177537	GDC Value Terminology	C54732	Preoperative	Relating to or occurring during the period immediately before a surgical operation.	Preoperative | timepoint_category	C198201	timepoint_category
A	C177537	GDC Value Terminology	C54734	Pre-Therapy	Occurring before a therapeutic procedure.	Prior to Treatment | timepoint_category	C198201	timepoint_category
A	C177537	GDC Value Terminology	C573	Surface Immunoglobulin	Immunoglobulin containing a transmembrane region and expressed on the plasma membrane of a B cell.  Contrast with secreted Ig which has no transmembrane region but which can still be bound to the cell surface via Fc receptors.	Immunoglobulin, Surface | antigen	C268	antigen
A	C177537	GDC Value Terminology	C6433	Endometrial Polyp	A benign nodular lesion protruding above the surface of the endometrium. It is composed of a fibrous stroma that contains thick-walled blood vessels and dilated endometrial glands. Polypectomy is the treatment of choice. Only few cases with recurrence have been reported.	Endometrial polyp | additional_pathology_findings	C158809	additional_pathology_findings
A	C177537	GDC Value Terminology	C64823	Monocyte Count	The determination of the number of monocytes in a blood sample.	Monocytes | laboratory_test	C25294	laboratory_test
A	C177537	GDC Value Terminology	C70622	Primary Induction Failure	A disease status whereby the patient does not achieve a complete remission. It may not be limited to the first/initial course of therapy; it may represent all courses.	Induction Failure | first_event	C198107	first_event
A	C177537	GDC Value Terminology	C71720	Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System	A diffuse large B-cell lymphoma arising from the central nervous system.	Primary diffuse large B-cell lymphoma of the CNS | primary_diagnosis	C177621	primary_diagnosis
A	C177537	GDC Value Terminology	C74084	TLR9 Agonist SD-101	A proprietary oligonucleotide with immunostimulatory activity. Immunostimulatory phosphorothiolate oligodeoxyribonucleotide SD-101 targets Toll-Like Receptor 9 (TLR9) found on a specialized subset of dendritic cells. The interaction of TLR9 with SD-101, in conjunction with an allergen or antigen, induces activation of memory T helper cells 1 (Th1) against a specific pathogen or allergen, thereby leading to long-lasting therapeutic effects. Furthermore, this agent does not cause a generalized activation of the immune system.	TLR9 Agonist SD-101 | therapeutic_agents	C1909	therapeutic_agents
A	C177537	GDC Value Terminology	C74605	Blast Count	The determination of the number of blast cells present in a biospecimen.	Blast Count | laboratory_test	C25294	laboratory_test
A	C177537	GDC Value Terminology	C75553	Salesperson	A person employed to sell goods or services especially to customers in a store or to customers that are visited within a geographic area.	Shop Salespersons | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C80245	Artist	One who uses imagination and talent or skill to create works of aesthetic value.	Creative and Performing Artists | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C81326	Elevated Test Result	A result of a test that is higher than a previous value or a normal range of values.	Elevated | test_result	C36292	test_result
A	C177537	GDC Value Terminology	C82470	Veterinarian		Veterinarians | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C82473	Veterinary Staff		Veterinary Technicians and Assistants | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C84637	Chronic Pancreatitis	A chronic inflammatory process causing damage and fibrosis of the pancreatic parenchyma. Signs and symptoms include abdominal pain, malabsorption and diabetes mellitus.	Chronic Pancreatitis | comorbidities || Chronic Pancreatitis | risk_factors	C16457 || C17103	comorbidities || risk_factors
A	C177537	GDC Value Terminology	C84932	Neurocysticercosis	A parasitic infection with tapeworms of the genus Taenia affecting the brain. It is manifested with seizures and headaches.	Neurocysticercosis | risk_factors	C17103	risk_factors
A	C177537	GDC Value Terminology	C85051	Rubella Infection	A viral infection caused by the rubella virus. It is initially manifested with flu-like symptoms that last one or two days, followed by the development of a characteristic red rash which lasts from one to five days. The rash first appears in the neck and face. It subsequently spreads to the rest of the body.	Rubella | risk_factors	C17103	risk_factors
A	C177537	GDC Value Terminology	C89345	Childhood	A time period that begins at the beginning of the human embryonic stage and continues until the end of adolescence.	Childhood | timepoint_category	C198201	timepoint_category
A	C177537	GDC Value Terminology	C9480	Invasive Carcinoma	A carcinoma that is not confined to the epithelium, and has spread to the surrounding stroma.	Invasive carcinoma of no special type | primary_diagnosis || Invasive carcinoma, NST | primary_diagnosis	C177621	primary_diagnosis
A	C177537	GDC Value Terminology	C95606	Second Primary Malignant Neoplasm	A primary malignant neoplasm in a patient who has been already diagnosed with a primary malignant neoplasm in another anatomic site.	Second Malignant Neoplasm | first_event	C198107	first_event
A	C177537	GDC Value Terminology	C97632	Farming, Fishing, and Forestry Occupations	A class of professional or vocational positions of employment that involve farming, fishing or forestry.	Agricultural, Forestry and Fishery Labourers | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C97637	Legal Occupations	A class of professional or vocational positions of employment that involve legal activities.	Legal Professionals | occupation_type	C25193	occupation_type
A	C177537	GDC Value Terminology	C97643	Protective Service Occupations	A class of professional or vocational positions of employment that involve protective services.	Protective Services Workers | occupation_type	C25193	occupation_type