NDF-RT Public Edition Release notes

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May 2008 NDF-RT (version name 2008.05.13)

This release of NDF-RT Public Edition contains 77 new concepts: 44 added to
the EXT hierarchy, 13 added to the PE hierarchy, 18 added to the MoA
hierarchy, and 2 added to the Chemical/Ingredient hierarchy.

Part of the large new concepts count is due to a reorganization of the Nervous
System PE hierarchy. The changed concepts count this month is due to 4 concept
name changes: Chemical Structures for Pharmacologic Classification
[Chemical/Ingredient] was changed to Chemical Classes for Pharmacologic
Classification [Chemical/Ingredient]; Neurological & Neuromuscular System
Activity Alteration [PE] was changed to Nervous System Activity Alteration
[PE]; NMDA Receptor Antagonist [MoA] was made plural; and Striated Muscle
Alteration [PE] was changed to Striated Muscle Metabolic Alteration [PE].

	 135,999 total concepts
	      77 new concepts
	       4 changed concepts
	       0 concepts removed

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April 2008 NDF-RT (version name 2008.04.08)

This release of NDF-RT Public Edition contains 10 new concepts: 24 added to
the EXT hierarchy, 7 added to the PE hierarchy, and 4 added to the MoA
hierarchy.

The changed concepts count this month is due to two concept name changes. The
old concept name Alcohol Dehyrogenase Inhibitors [MoA] was changed to include
"Dehydrogenase", the correct spelling. The concept Angiotensin-Converting
Enzyme Inhibitors [MoA] was changed to make "-Converting" lowercase for
consistency with other hyphenated NDF-RT concept names.

	 135,922 total concepts
	      35 new concepts
	       2 changed concepts
	       0 concepts removed

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March 2008 NDF-RT (version name 2008.03.11)

This release of NDF-RT Public Edition contains 10 new concepts: 8 added to the
EXT hierarchy, and 2 added to the MoA hierarchy.

The changed concepts count this month is due to concept name
changes. Instances of the acronym "GNRH" in 4 existing concept names in the PE
hierarchy were changed to "GnRH". In addition, the following changes to EXT
concept names were made, with the former concept names retained as synonyms:
Angiotensin 2 Receptor Blocker [EXT], Phosphodiesterase 3 Inhibitor [EXT], and
Phosphodiesterase 5 Inhibitor [EXT] were renamed to include Roman numerals, to
replicate the original pharmacologic class requested phrases; Greek letters in
the concept names Interferon Alpha [EXT] and Interferon Gamma [EXT] were
lowercased; and GnRH Secretion Inhibitor [EXT] was changed to reflect the
fully-specified name Gonadotropin Releasing Hormone Secretion Inhibitor [EXT].

	 135,887 total concepts
	      10 new concepts
	      12 changed concepts
	       0 concepts removed

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February 2008 NDF-RT (version name 2008.02.12)

This release of NDF-RT Public Edition contains 41 new concepts: 13 added to
the EXT hierarchy, 11 added to the MoA hierarchy, and 17 added to the PE
hierarchy.

The changed concepts count is due to subtree reorganization under the new
concept Autonomic Nervous System Activity Alteration [PE]. In addition to this
hierarchy reorganization, a second parent was given to any legacy
neurotransmitter-specific sympathetic/parasympathetic activity concepts in the
new subtree. Finally, a number of concept names containing "Norepinepherine"
were changed to reflect the correct spelling.

	 135,877 total concepts
	      41 new concepts
	      37 changed concepts
	       2 concepts removed

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January 2008 NDF-RT (version name 2008.01.08)

This release of NDF-RT Public Edition contains changes reflecting decisions
made at the November 2007 SPL IEP face-to-face meeting. The former Additional
FDA Pharmacologic Classes for SPL hierarchy has been renamed to "External
Pharmacologic Classes", and now contains new concepts whose names replicate
each pharmacologic class string received. These concepts are mapped via role
relationships to appropriate MoA, PE, or Chemical/Ingredient concepts. All
concepts in this hierarchy have the tag [EXT] appended to their names,
replacing the former [FDA SPL] tag. In addition to new concepts created
manually in this hierarchy to reflect recent SPL IEP decisions, 61 concepts
were added programmatically from former FDA_SPL_Name property values that
existed for those NDF-RT concepts considered to be one-to-one maps to SPL
pharmacologic class phrases. These EXT concept names exactly replicate the
former FDA_SPL_Name property values. All existing FDA_SPL_Name property values
were then removed, and as this property will no longer be used, the property
type has been removed entirely from NDF-RT.

In addition to these 61 concepts added programmatically, there were 72 new
concepts added to the EXT hierarchy based on submissions from the
Antimicrobial/Transplant/Hematology FDA list. Other new concepts included 6
added to the Chemical/Ingredient hierarchy, 5 added to the PE hierarchy, and
11 added to the MoA hierarchy.

The changed concepts count is due to 14 MoA concepts, which were renamed for
consistency to include "Activity" instead of "Agents", "Preparations", or
"Scavengers", and one concept whose former name contained an incorrect
spelling. Additionally, 29 existing concepts in the EXT (formerly Additional
FDA Pharmacologic Classes for SPL) hierarchy were renamed, removing the [FDA
SPL] tag and adding the new [EXT] tag.

The concept Influenza Neuraminidase Inhibitors [MoA] was retired. The
newly-created concept Influenza Neuraminidase Inhibitor [EXT] retains this
former concept's NUI.

	 135,838 total concepts
	     145 new concepts
	      43 changed concepts
	       1 concept removed

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November 2007 NDF-RT (version name 2007.11.13)

This release of NDF-RT Public Edition contains 11 new concepts: 4 added in the
Additional FDA Pharmacologic Classes for SPL list, 6 added to the MoA
hierarchy, and 1 added to the Chemical/Ingredient hierarchy.

The changed concepts count is due to two renamed MoA concepts, Tumor Necrosis
Factor Alpha Receptor Blocking Activity [MoA], and Tumor Necrosis Factor Beta
Receptor Blocking Activity [MoA].

	135,684 total concepts
	     11 new concepts
	      2 changed concepts
	      0 concepts removed

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October 2007 NDF-RT (version name 2007.10.09)

This release of NDF-RT Public Edition contains 17 new concepts: 8 added in the
Additional FDA Pharmacologic Classes for SPL list, 1 added to Supplementary
Chemicals [Chemical/Ingredient], 1 added to the PE hierarchy, 5 added to the
MoA hierarchy, and 2 added to the Chemical/Ingredient hierarchy.

An official NDF-RT SPL IEP decision was made to add a second FDA_SPL_Name,
beta-Adrenergic Receptor Inhibitor, to the concept Adrenergic beta-Antagonists
[MoA], which was mapped to both the New Products pharm. class phrase with the
same string and the Cardiac/Renal submission beta-adrenergic blocker. Going
forward, this approach will ONLY be used when the FDA_SPL_Name values are true
synonyms.

	135,673 total concepts
	     17 new concepts
	      0 changed concepts
	      0 concepts removed

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August/September 2007 NDF-RT (version name 2007.08.31)

This full release of NDF-RT Public Edition contains the new "Additional FDA
Pharmacologic Classes for SPL" list under "Pharmaceutical Preparations". Its
16 assigned children were created in response to requests for concepts to
support the FDA Structured Product Labeling (SPL) initiative. Concepts in this
group represent specific requests for SPL Pharmacologic Class phrases that can
not be represented by a single new or existing MOA, PE or CS NDF-RT
concept. This includes phrases that represent therapeutic intent as defined by
the FDA SPL initiative, as well as those represented by the concatenation of
multiple NDF-RT concepts, and in rare cases ideas that did not fit elsewhere
within NDF-RT. None of the concepts in this new group are listed in the MOA,
PE or CS SPL files published separately but many have defining role
relationships to one or more MOA, PE and CS concepts.

The changed concepts count includes concepts changed for remodeling of the
Nucleic Acid Synthesis Inhibitors [MoA], Protease Inhibitors [MoA], and Kinase
Inhibitors [MoA] subtrees, as well as concepts affected by new FDA_SPL_Name
algorithm, and two concepts renamed due to misspellings. Fms-like tyrosine
kinase (FLT) Inhibitors [MoA] was removed after determining that it was not
used as a role value for NDF-RT drug modeling.

	135,656 total concepts
	     17 new concepts
	     78 changed concepts
	      1 concept removed

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July 2007 NDF-RT (version name 2007.07.10)

This Full release of NDF-RT Public Edition contains no added concepts based on
FDA submissions for SPL. Changes in this version of NDF-RT occurred solely due
to a few changes and 85 additional mappings of NDF-RT Disease concepts that
already had at least one existing SNOMED CT mapping. None of these were on the
current SPL Problem List (Jan. 2007). These changes resulted in the creation
of at least one additional map from that Disease concept to a SNOMED CT
concept on the SPL Problem List. A map (recorded as a property on the concept)
to a SNOMED CT concept on the SPL Problem List will now be called the
SPL_Problem_List_Mapping_ID. In addition, the existing SNOMED_ID property was
renamed to SNOMED_Mapping_ID. This final change resulted in the large
changed concept count.

	135,640 total concepts
	      0 new concepts
	   2478 changed concepts 
	      
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June 2007 NDF-RT (version name 2007.06.12)

This Full release of NDF-RT Public Edition contains changes derived from SPL
Pharmacologic Class requirements plus changes derived from a
re-synchronization of the Chemical/Ingredient hierarchy with the current
version of MeSH (2007).

    135,640 total current concepts
	324 new concepts
	 33 changed concepts
	 21 deprecated concepts (reflects semantic duplicates noted either due
	    to formal SPL decisions or MeSH refresh QA process. Prior meanings
	    and NUIs of these concepts are attributed to existing NDF-RT
	    concepts.)

A substantial reduction in the number of synonyms is reflected in this release
due to the improved accuracy of synonym assignment based on UMLS
Metathesaurus. Removed synonyms were all from the Chemical/Ingredient
hierarchy. Chemicals and Ingredients concepts were derived from 2007 ASCII
MeSH files.

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May 2007 NDF-RT (version name 2007.05.08)

Starting with the May 2007 release a new property has been created:
FDA_SPL_Name. This property will only be added to concepts when there is
requirement for a concept representation (IE: a term name) preferred for SPL
use that is not the existing “preferred name” for the concept. 

The value of the FDA_SPL_Name property may be an existing synonym, or it may
be a new term representation. If it is new, it will only be additionally added
as a synonym for concepts NOT derived from MeSH. This was done to keep
synonyms algorithmically consistent with the UMLS MeSH synonym list for that
concept (as noted above.) Only concepts requiring these additions will carry
this property. This means that any SPL user must determine if that property
exists for a concept and use the value as the concept preferred name.

This Full release of NDF-RT Public Edition contains only a few changes
modeled and approved by the ICCB committee.

  135,337 total current concepts
        6 new concepts
        1 changed concept
        1 retired concept

Chemicals and ingredient concepts were derived from MeSH 2006 (2006_05_01)

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April 2007 NDF-RT (version name 2007.04.10)

This Full release of NDF-RT Public Edition contains only a few changes modeled
and approved by the ICCB committee.

  135,332 total current concepts
       10 new concepts
        1 changed concept
        1 retired concept

Chemicals and ingredient concepts were derived from MeSH 2006 (2006_05_01)

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March 2007 NDF-RT (version name 2007.03.13)

As of the March, 2007, the provision of NDF-RT content outside the VA system
will not include elements deemed only of value to internal VA operations. This
"extract" will be known as the NDF-RT Public Edition and will contain all of
the core NDF-RT concepts that existed in previous releases and all concept
NUIs will remain unchanged. In essence the Public Edition only removes
selected VA-specific properties, qualifiers, associations and a few Kinds that
represented information required for unique internal VA activities. All Roles
remain unchanged.

These changes are expected to have no impact on non-VA use of the NDF-RT.

Listed below are the changes implemented beginning with this release.

***********************************************
**ELEMENTS PRESERVED IN NDF-RT PUBLIC EDITION**
***********************************************
<Selected KINDS>
	NDF_KIND		{formerly DRUG_KIND}
	INGREDIENT_KIND
	MECHANISM_OF_ACTION_KIND
	PHYSIOLOGIC_EFFECT_KIND 
	PHARMACOKINETICS_KIND
	DISEASE_KIND
	RECIP_STRUCTURES_KIND
	RXNORM_DOSE_FORM_KIND

<All ROLES>	Source -> Target
	has_Ingredient	NDF_KIND  -->  INGREDIENT_KIND
	CI_ChemClass	NDF_KIND  -->  INGREDIENT_KIND
	metabolized_by	NDF_KIND  -->  INGREDIENT_KIND
	has_active_metabolites	NDF_KIND  -->  INGREDIENT_KIND
	effect_may_be_inhibited_by	NDF_KIND  -->  NDF_KIND
	metabolized_by_recip_structure	NDF_KIND  -->  RECIP_STRUCTURES_KIND
	gene_encodes_for	RECIP_STRUCTURES_KIND  -->  INGREDIENT_KIND
	gene_has_variant	RECIP_STRUCTURES_KIND  -->  RECIP_STRUCTURES_KIND
	gene_encodes_for_enzyme	RECIP_STRUCTURES_KIND  -->  RECIP_STRUCTURES_KIND
	has_MoA	NDF_KIND  -->  MECHANISM_OF_ACTION_KIND
	CI_MoA	NDF_KIND  -->  MECHANISM_OF_ACTION_KIND
	has_PE	NDF_KIND  -->  PHYSIOLOGIC_EFFECT_KIND
	CI_PE	NDF_KIND  -->  PHYSIOLOGIC_EFFECT_KIND
	has_PK	NDF_KIND  -->  PHARMACOKINETICS_KIND
	site_of_metabolism	NDF_KIND  -->  PHARMACOKINETICS_KIND
	may_treat	NDF_KIND  -->  DISEASE_KIND
	may_prevent	NDF_KIND  -->  DISEASE_KIND
	may_diagnose	NDF_KIND  -->  DISEASE_KIND
	induces	NDF_KIND  -->  DISEASE_KIND
	CI_with	NDF_KIND  -->  DISEASE_KIND
	has_DoseForm	NDF_KIND  -->  RXNORM_DOSE_FORM_KIND

<Selected ASSOCIATIONS>
	Heading_Mapped_To	INGREDIENT_KIND  --> INGREDIENT_KIND
	VA_Product_Component	NDF_KIND -->  NDF_KIND
	VA_Secondary_Drug_Class	NDF_KIND -->  NDF_KIND

<Selected ASSOCIATION QUALIFIERS>
	VA_Strength
	VA_Unit

<Selected PROPERTIES>
	NUI
	Display_Name
	Synonym
	Level
	Status
	Status_Change_Date
	Review_Status
	MeSH_Name
	MeSH_UI
	Included_MeSH_UIs
	MeSH_Definition
	MeSH_Pharmacologic_Action
	NCI_Preferred_Term
	RxNorm_CUI
	RxNorm_Code
	RxNorm_Name
	RxNorm_Preferred_Translation_Term
	SNOMED_ID
	UNII
	UMLS_CUI
	UMLS_Semantic_Type
	UMLS_Preferred_Translation_Term
	VUID
	VA_Class_Description
	VA_Class_Code
	VA_Class_Type
	VA_CS_Federal_Schedule
	VA_Manufacturer_Code
	VA_National_Formulary_Name
	VA_NDC
	VA_NDF_Type
	VA_Product_Code
	VA_Package_Code
	VA_Print_Name
	VA_RxOtc_Indicator
	VA_Strength
	VA_Trade_Name
	VA_Units
	VA_UPN

<Selected PROPERTY QUALIFIERS>
	Date
	Status
	VUID

***********************************************************
**VA-SPECIFIC ELEMENTS REMOVED FROM NDF-RT PUBLIC EDITION**
***********************************************************
<Selected KINDS>
	EXTERNAL_REFERENCE_KIND
	VA_DISPENSE_UNITS_KIND
	VA_DOSE_FORMS_KIND
	VA_DRUG_INTERACTION_KIND
	VA_DRUG_MANUFACTURER_KIND
	VA_DRUG_UNIT_KIND
	VA_NATIONAL_FORMULARY_RESTRICTION_KIND
	VA_PACKAGE_SIZE_KIND
	VA_PACKAGE_TYPE_KIND
	VA_ROUTE_OF_ADMINISTRATION_KIND

<Selected ASSOCIATIONS>
	External_Dispense_Unit
	External_Dose_Form
	External_Package_Size
	External_Package_Type
	External_ROA
	VA_Dispense_Units
	VA_Dose_Form
	VA_Dose_Form_Units
	VA_Drug_Manufacturer
	VA_Ingredient_1
	VA_Ingredient_2
	VA_National_Formulary_Restriction
	VA_Package_Size
	VA_Package_Type
	VA_ROA

<Selected ASSOCIATION QUALIFIERS>
	FILE
	IEN
	PACKAGE

<Selected PROPERTIES>
	Search_Name
	Last_Reviewed
	Reviewed_By
	Comment
	Alert
	VA_Abbreviation
	VA_Discontinue
	VA_Dispense_Units_Per_Dose
	VA_Dose_Form_Print_Name
	VA_Drug_Identifier
	VA_DSS_Number
	VA_Exclude_Drug_Interaction_Check
	VA_File
	VA_IvFlag
	VA_Max_Cumulative_Dose
	VA_Max_Daily_Dose
	VA_Max_Single_Dose
	VA_Min_Daily_Dose
	VA_Min_Single_Dose
	VA_Nationally_Entered
	VA_National_Formulary_Indicator
	VA_NDT_XML
	VA_Package_Use
	VA_Product_Identifier
	VA_Severity
	VA_Single_or_Multi_Source_Product
	VA_Total_Indexes
	VA_Transaction_History
	VA_Transmit_to_CMOP
	VA_User_Lock
	VA_Workflow_Comment
	VA_Workflow_Status

<Selected PROPERTY QUALIFIERS>
	User Name
	VA_Class_Description_Line
	VA_File
	VA_IEN
	VA_PACKAGE

NDF-RT Public Edition Release notes
Created on 3/23/07