Subset Code Subset Name Concept Code NCIt Preferred Term NCIt Definition CTDC Preferred Term CTDC Synonyms(s) CTDC Display Name C173071 CTDC Node Terminology C70699 Biospecimen "Any material sample taken from a biological entity for testing, diagnostic, propagation, treatment or research purposes, including a sample obtained from a living organism or taken from the biological object after halting of all its life functions. Biospecimen can contain one or more components including but not limited to cellular molecules, cells, tissues, organs, body fluids, embryos, and body excretory products." specimen C173071 CTDC Node Terminology C49152 Case A problem requiring investigation. case C173071 CTDC Node Terminology C71104 Clinical Trial A research study that prospectively assigns human participants or groups of humans to one or more health-related interventions to evaluate the effects on health outcomes. clinical_trial clinical trial C173071 CTDC Node Terminology C40207 Copy Number Polymorphism Variation in the number of copies of a particular sequence within the genetic material of an individual. Large-scale copy number polymorphisms are common and widely distributed in the human genome. copy_number_variant copy number variant C173071 CTDC Node Terminology C171175 Delins Mutation "A change in a nucleotide sequence where nucleotides in a reference sequence are replaced by other nucleotides and which is not a substitution, inversion or conversion." delins_variant delins variant C173071 CTDC Node Terminology C20195 Gene Fusion "Any hybrid gene formed from two previously separate genes. Such fusions occur as a result of translocation, intersititial deletion or chromosomal inversion, and often result in gene products with functions different from the two fusion partners. Gene fusions are associated frequently with hematological cancers, sarcomas and prostate cancer." gene_fusion_variant gene fusion variant C173071 CTDC Node Terminology C172232 Immunohistochemistry Assay Report A short document that describes the data related to an immunohistochemical assay performed on a sample. ihc_assay_report ihc assay report C173071 CTDC Node Terminology C99752 Indel Mutation "A mutation class that includes insertion mutations, deletion mutations and mutation events where both an insertion and a deletion has occurred." indel_variant indel variant C173071 CTDC Node Terminology C171176 Nucleic Acid Aliquot A sample comprised of nucleic acids isolated from tissues or cells derived from an experimental subject and disolved in an aqueous solution. nucleic_acid nucleic acid C173071 CTDC Node Terminology C18881 Nucleic Acid Sequencing The process of determining the sequence of purines and pyrimidines in nucleic acids and polynucleotides. sequencing_assay sequencing assay C173071 CTDC Node Terminology C15538 Protocol Treatment Arm A specific treatment plan within a clinical trial that describes the activities a subject will be involved in as he or she progresses through the study. arm C173071 CTDC Node Terminology C172231 Protocol Treatment Arm Assignment Report A short document that describes the test results and rationale that determined which treatment arm a subject was assigned to. assignment_report assignment report C173071 CTDC Node Terminology C171178 Sequence Variant Report A short document listing the sequence variants found in a sample. variant_report variant report C173071 CTDC Node Terminology C171177 Sequencing Data File An electronic file containing nucleic acid sequencing data. file C173071 CTDC Node Terminology C164674 Single Nucleotide Variant "A variation of a single nucleotide at a specific location of the genome due to base substitution, which is found at any frequency in the population." snv_variant snv variant C173071 CTDC Node Terminology C172233 Site of Metastasis The anatomical location where metastasis was detected. metastatic_site metastatic site C173072 CTDC Property Terminology C173074 Aliquot Unique Identifier A unique identifier assigned to an aliquot containing a portion of a biospecimen. aliquot_id aliquot id C173072 CTDC Property Terminology C94536 Best Overall Response The most clinically favorable response recorded from the start of the study treatment until the end of treatment. treatment_outcome treatment outcome C173072 CTDC Property Terminology C171259 Biopsy Molecular Sample Aliquot Unique Identifier A unique identifier assigned to the aliquot of nucleic acid that was derived from a subject's biopsy. molecular_sequence_number molecular sequence number C173072 CTDC Property Terminology C171262 Biopsy Sample Unique Identifier A unique identifier assigned to a subject's biopsy sample. biopsy_sequence_number biopsy sequence number C173072 CTDC Property Terminology C123556 Cancer Cellularity Measurement The determination of the ratio of neoplastic cells compared to total cells in a sample. The measurement may be expressed as a ratio or percentage. cellularity C173072 CTDC Property Terminology C164324 Case Identifier A unique alphanumeric identifier assigned to a specific case. case_id case id Case ID C173072 CTDC Property Terminology C13202 Chromosome "One of the bodies in the cell nucleus that is the bearer of genes, has the form of a delicate chromatin filament during interphase, contracts to form a compact cylinder segmented into two arms by the centromere during metaphase and anaphase stages of cell division, and is capable of reproducing its physical and chemical structure through successive cell divisions." chromosome C173072 CTDC Property Terminology C171186 Clinical Diagnosis by CTEP Disease Category A clinical diagnosis designation using a category term in the NCI Cancer Therapeutic Evaluation Program (CTEP) Simplified Disease Classification (SDC) terminology. ctep_category ctep category C173072 CTDC Property Terminology C171187 Clinical Diagnosis by CTEP Disease Sub-Category A clinical diagnosis designation using a sub-category term in the NCI Cancer Therapeutic Evaluation Program (CTEP) Simplified Disease Classification (SDC) terminology. ctep_subcategory ctep subcategory C173072 CTDC Property Terminology C172238 Clinical Trial Description A description of the clinical trial. clinical_trial_description clinical trial description Trial Description C173072 CTDC Property Terminology C172239 Clinical Trial Designation An abbreviation or short name used as an identifier for a trial. clinical_trial_designation clinical trial designation Trial Code C173072 CTDC Property Terminology C171263 Clinical Trial Long Name The complete name or title of a clinical trial. clinical_trial_long_name clinical trial long name Trial Name C173072 CTDC Property Terminology C171183 Clinical Trial Short Name An abbreviated form of the name or title of a clinical trial. clinical_trial_short_name clinical trial short name Trial Name C173072 CTDC Property Terminology C172240 Clinicaltrials.gov Identifier The unique alphanumeric identifier for a trial as assigned by the Clinicaltrials.gov Protocol Registration and Results System (PRS). clinical_trial_id clinical trial id Trial ID C173072 CTDC Property Terminology C49142 Copy Number The number of molecules of a particular type on or in a cell or part of a cell. Usually applied to specific genes or to plasmids within a bacterium. copy_number copy number C173072 CTDC Property Terminology C171275 Copy Number Median Absolute Percentage Deviation A statistical measure of the accuracy of copy number predictions made by a variant calling pipeline. mapd C173072 CTDC Property Terminology C2991 Disease or Disorder "Any abnormal condition of the body or mind that causes discomfort, dysfunction, or distress to the person affected or those in contact with the person. The term is often used broadly to include injuries, disabilities, syndromes, symptoms, deviant behaviors, and atypical variations of structure and function." disease Diagnosis C173072 CTDC Property Terminology C105721 ECOG Performance Status A performance status scale designed to assess disease progression and its affect on the daily living abilities of the patient. ecog_performance_status ecog performance status C173072 CTDC Property Terminology C172272 Electronic File Content Type The nature of the content stored in an electronic file. file_type file type File Type C173072 CTDC Property Terminology C171190 Electronic File Description A free text field that can be used to document details about an electronic file that may not be captured elsewhere. file_description file description C173072 CTDC Property Terminology C171252 Electronic File Format The format of an electronic file. file_format file format Format C173072 CTDC Property Terminology C171191 Electronic File Name The literal identifier for an electronic file. file_name file name File Name C173072 CTDC Property Terminology C171192 Electronic File Size The size of an electronic file. file_size file size Size C173072 CTDC Property Terminology C171193 Electronic File Status The condition for an electronic file relative to the current data or file processing step. file_status file status C173072 CTDC Property Terminology C171184 Estimated Copy Number 5 Percent Confidence Interval The lower limit of the 95 percent confidence interval for the estimated copy number. copy_number_ci_5 copy number ci 5 C173072 CTDC Property Terminology C171185 Estimated Copy Number 95 Percent Confidence Interval The upper limit of the 95 percent confidence interval for the estimated copy number. copy_number_ci_95 copy number ci 95 C173072 CTDC Property Terminology C16564 Ethnic Group A social group characterized by a distinctive social and cultural tradition that is maintained from generation to generation. Members share a common history and origin and a sense of identification with the group. They have similar and distinctive features in their lifestyle habits and shared experiences. They often have a common genetic heritage which may be reflected in their experience of health and disease. ethnicity Ethnicity C173072 CTDC Property Terminology C171255 Fusion Gene Downstream Gene Read Count The read count for the sequence of the gene that comprises the 3' portion of the coding sequence for a fusion gene. gene2_read_count gene2 read count C173072 CTDC Property Terminology C171253 Fusion Gene Downstream Gene Symbol The gene symbol that represents the gene that comprises the 3' portion of the coding sequence for a fusion gene. gene2 C173072 CTDC Property Terminology C171254 Fusion Gene Upstream Gene Read Count The read count for the sequence of the gene that comprises the 5' portion of the coding sequence for a fusion gene. gene1_read_count gene1 read count C173072 CTDC Property Terminology C171250 Fusion Gene Upstream Gene Symbol The gene symbol that represents the gene that comprises the 5' portion of the coding sequence for a fusion gene. gene1 C173072 CTDC Property Terminology C17357 Gender The assemblage of properties that distinguish people on the basis of the societal roles expected for the two sexes. gender Gender C173072 CTDC Property Terminology C40342 Gene Physical Location The physical location of a gene expressed as chromosome and start and end base positions. position C173072 CTDC Property Terminology C97928 Gene Product Sequence Variation A variation in the amino acid sequence of a specific gene product. amino_acid_change amino acid change C173072 CTDC Property Terminology C43568 Gene Symbol A unique gene name approved by an organism specific nomenclature committee. gene C173072 CTDC Property Terminology C171273 Gene Symbol of Target in Immunohistochemistry Assay The gene symbol that represents the target analyte assayed during an immunohistochemical test. ihc_test_gene ihc test gene C173072 CTDC Property Terminology C97927 Gene Variant A variation in the nucleic acid sequence of a specific gene. alternative C173072 CTDC Property Terminology C164388 Genetic Reference Sequence A published genetic sequence that is used as a reference sequence against which other sequences are compared. reference C173072 CTDC Property Terminology C17248 Genetic Variation "Genetic Variation consists of deviation(s) in the nucleotide sequence of the genetic material of an individual from that typical of the group to which the individual belongs, or deviation(s) in the nucleotide sequence of the genetic material of offspring from that of its parents." variant_classification variant classification C173072 CTDC Property Terminology C164813 Genetic Variation Identifier A unique identifier maintained by an authoritative database that represents a genetic variation. external_variant_id || variant_id external variant id || variant id C173072 CTDC Property Terminology C164815 Genome Assembly Version The source-specific version of the published genome assembly. reference_genome reference genome C173072 CTDC Property Terminology C172243 HGVS Genomic Variation Annotation The designation of an observed genomic variation based on the Human Genome Variation Society (HGVS) nomenclature guidelines. genomic_hgvs genomic hgvs C173072 CTDC Property Terminology C172244 HGVS Transcript Variation Annotation The designation of an observed transcript variation based on the Human Genome Variation Society (HGVS) nomenclature guidelines. transcript_hgvs transcript hgvs C173072 CTDC Property Terminology C125007 Histopathology Result The outcome of a microscopic pathologic examination using various cytochemical and immunocytochemical stains. ihc_test_result ihc test result C173072 CTDC Property Terminology C171272 Immunohistochemistry Assay Unique Identifier A unique identifier assigned to raw or processed data from a performed immunohistochemistry assay. ihc_assay_id ihc assay id C173072 CTDC Property Terminology C63409 Lead Organization The principal administrative organization responsible for the research conducted. lead_organization lead organization Lead Organization C173072 CTDC Property Terminology C172251 MATCH Step at Time of Assignment The step in the MATCH workflow at which a subject has been assigned to a treatment arm. step_at_assignment step at assignment C173072 CTDC Property Terminology C171276 MD5 Checksum A 32-character hexadecimal number that is computed on a file. md5sum C173072 CTDC Property Terminology C117056 MedDRA Preferred Term Code A coded value specifying the preferred term from the Medical Dictionary for Regulatory Activities (MedDRA). meddra_code meddra code C173072 CTDC Property Terminology C172389 Metastatic Site Code A coded value specifying the anatomic site where metastasis was detected. met_site_id met site id C173072 CTDC Property Terminology C171335 NCBI Transcript Identifier An identifier assigned by National Center for Biotechnology Information (NCBI) to an RNA transcript. transcript_id transcript id C173072 CTDC Property Terminology C166229 Normal or Tumor Sample Pathology Indicator Specifies whether a sample is derived from normal or tumor-bearing tissue. specimen_type specimen type C173072 CTDC Property Terminology C172246 Nucleic Acid Aliquot Volume The volume of fluid in an aliquot containing nucleic acid extracted from a specimen. nucleic_acid_volume nucleic acid volume C173072 CTDC Property Terminology C171277 Nucleic Acid Concentration The measured concentration of nucleic acid in a sample. nucleic_acid_concentration nucleic acid concentration C173072 CTDC Property Terminology C171278 Nucleic Acid Sample Type Indicator "Specifies the type of nucleic acid (DNA, RNA, Pooled, etc.) found in a sample." nucleic_acid_type nucleic acid type C173072 CTDC Property Terminology C18881 Nucleic Acid Sequencing The process of determining the sequence of purines and pyrimidines in nucleic acids and polynucleotides. experimental_method experimental method C173072 CTDC Property Terminology C172250 Oncomine Variant Type The variant type assigned by the proprietary Oncomine assay. oncomine_variant_class oncomine variant class C173072 CTDC Property Terminology C47922 Pathname "The specification of a node (file or directory) in a hierarchical file system, usually specified by listing the nodes top-down." file_location file location C173072 CTDC Property Terminology C164337 Patient Identifier An alphanumeric identifier assigned to a specific patient. source_id source id C173072 CTDC Property Terminology C166244 Patient Status An indicator that provides information on the current health status of a patient. patient_status patient status C173072 CTDC Property Terminology C172271 Patient Status Following Protocol Treatment Arm Assignment The status of a patient following assignment to a treatment arm. assignment_outcome assignment outcome C173072 CTDC Property Terminology C19924 Principal Investigator An investigator who is responsible for all aspects of the conduct of a study. principal_investigators principal investigators Principal Investigators C173072 CTDC Property Terminology C82522 Prior Medication Usage An indication or description that medications were taken previously. prior_drugs prior drugs C173072 CTDC Property Terminology C171182 Protocol Treatment Arm Assignment Rationale The rationale used for assigning a subject to a study arm. assignment_logic assignment logic C173072 CTDC Property Terminology C172237 Protocol Treatment Arm Assignment Report Unique Identifier A unique identifier assigned to a protocol arm assignment report. assignment_report_id assignment report id C173072 CTDC Property Terminology C172236 Protocol Treatment Arm Drug Name The name of the therapeutic agent or agents administered in a specific arm of a study. arm_drug arm drug Treatment Arm Drug C173072 CTDC Property Terminology C172275 Protocol Treatment Arm Molecular Target A description of the molecular target(s) of a protocol arm. arm_target arm target Treatment Arm Target C173072 CTDC Property Terminology C171181 Protocol Treatment Arm Unique Identifier A unique identifier assigned to a protocol treatment arm. arm_id arm id Treatment Arm C173072 CTDC Property Terminology C127797 PubMed Identifier for Citation Used in Study "A globally unique identifier for a biomedical article, as assigned by PubMed." pubmed_id pubmed id PubMed ID C173072 CTDC Property Terminology C17049 Race A geographic ancestral origin category that is assigned to a population group based mainly on physical characteristics that are thought to be distinct and inherent. race Race C173072 CTDC Property Terminology C172253 Sequence Variant Report Unique Identifier A unique identifier assigned to each variant report. variant_report_id variant report id C173072 CTDC Property Terminology C171337 Sequencing Assay Unique Identifier A unique identifier assigned to raw data from a performed nucleic acid sequencing assay. sequencing_assay_id sequencing assay id C173072 CTDC Property Terminology C172274 Sequencing Platform Name The name of the technology platform used to perform nucleic acid sequencing. platform C173072 CTDC Property Terminology C171338 Sequencing Quality Control Result Metadata collected during nucleic acid sequencing that can be used as a measure of the quality of the sequencing run. qc_result qc result C173072 CTDC Property Terminology C172273 Site of Metastasis at Trial Entry The anatomical location where metastasis was detected at the time the subject has entered the trial. metastatic_site_name metastatic site name C173072 CTDC Property Terminology C166393 Specimen Identifier A unique alphanumeric identifier assigned to a specimen. specimen_id specimen id C173072 CTDC Property Terminology C171336 Torrent Variant Caller Version Text A string identifying a form or variant of the Ion Torrent variant caller used in a study. torrent_variant_caller_version torrent variant caller version C173072 CTDC Property Terminology C16154 Treatment Step A specific stage of progression through a sequential treatment protocol. current_step current step C173072 CTDC Property Terminology C49660 Trial Type "The type of clinical trial performed e.g. efficacy, safety." clinical_trial_type clinical trial type Trial Type C173072 CTDC Property Terminology C171334 Tumor Suppressor Gene Indicator An indication as to whether a gene or variant is a tumor suppressor. tumor_suppressor tumor suppressor C173072 CTDC Property Terminology C70663 Unique Identifier "A set of characters used as a code that is unique in the context or the system for which it is created. It serves as a means of identification and reference (often instead of a name) for an entity, person, thing, function, procedure, activity, variable, or body of data." uuid C173072 CTDC Property Terminology C154665 Variant Allele Frequency The relative rate of occurrence of a specific variant allele within a population. allele_frequency allele frequency C173072 CTDC Property Terminology C171188 Variant Exon The exon of a gene that contains the nucleotide variation that was identified by nucleic acid sequencing. exon C172126 CTDC Terminology C173071 CTDC Node Terminology Terminology that supports the key trial entities (nodes) in the Clinical Trials Data Commons (CTDC) data model. C172126 CTDC Terminology C173072 CTDC Property Terminology Terminology that supports the data properties in the Clinical Trials Data Commons (CTDC) data model. C172126 CTDC Terminology C173073 CTDC Value Terminology Terminology that supports the values associated with data properties in the Clinical Trials Data Commons (CTDC) data model.