Release Date	Request Code	Change Type	NCI Code	CDISC Term Type	CDISC Codelist (Short Name)	CDISC Codelist (Long Name)	Change Summary	Original	New	Change Implementation Instructions
2023-09-29	CDISC-5993	Add	C201379	Term	FREQ	Frequency	Add new term to existing codelist	- - -	EVERY 8 YEARS	
2023-09-29	CDISC-5817	Add	C201427	Term	LBTEST	Laboratory Test Name	Add new term to existing codelist	- - -	Aspartate Aminotransferase Isoenzyme C	
2023-09-29	CDISC-5818	Add	C201428	Term	LBTEST	Laboratory Test Name	Add new term to existing codelist	- - -	Aspartate Aminotransferase Isoenzyme M	
2023-09-29	CDISC-5835	Add	C201429	Term	LBTEST	Laboratory Test Name	Add new term to existing codelist	- - -	Monocyte Distribution Width	
2023-09-29	CDISC-5835	Add	C201430	Term	LBTEST	Laboratory Test Name	Add new term to existing codelist	- - -	Phenylpyruvate	
2023-09-29	CDISC-5835	Add	C201431	Term	LBTEST	Laboratory Test Name	Add new term to existing codelist	- - -	DU-PAN-2	
2023-09-29	CDISC-5817	Add	C201427	Term	LBTESTCD	Laboratory Test Code	Add new term to existing codelist	- - -	ASTC	
2023-09-29	CDISC-5818	Add	C201428	Term	LBTESTCD	Laboratory Test Code	Add new term to existing codelist	- - -	ASTM	
2023-09-29	CDISC-5835	Add	C201429	Term	LBTESTCD	Laboratory Test Code	Add new term to existing codelist	- - -	MDW	
2023-09-29	CDISC-5835	Add	C201430	Term	LBTESTCD	Laboratory Test Code	Add new term to existing codelist	- - -	PHNPYR	
2023-09-29	CDISC-5835	Add	C201431	Term	LBTESTCD	Laboratory Test Code	Add new term to existing codelist	- - -	DUPAN2	
2023-09-29	CDISC-5871	Add	C12371	Term	LOC	Anatomical Location	Add new term to existing codelist	- - -	MYOCARDIUM	
2023-09-29	CDISC-5811	Add	C139164	Term	LOC	Anatomical Location	Add new term to existing codelist	- - -	MEDIAL NASAL TURBINATE	
2023-09-29	CDISC-5565	Add	C201432	Term	LOC	Anatomical Location	Add new term to existing codelist	- - -	MECKELS CAVE	
2023-09-29	CDISC-5871	Add	C201433	Term	LOC	Anatomical Location	Add new term to existing codelist	- - -	HEART, RIGHT VENTRICLE, BASE	
2023-09-29	CDISC-5871	Add	C201434	Term	LOC	Anatomical Location	Add new term to existing codelist	- - -	HEART, RIGHT VENTRICLE, MID-LEVEL	
2023-09-29	CDISC-5888	Add	C201435	Term	LOC	Anatomical Location	Add new term to existing codelist	- - -	POSTERIOR LIMB OF INTERNAL CAPSULE	
2023-09-29	CDISC-6015	Add	C201464	Term	PKPARM	PK Parameters	Add new term to existing codelist	- - -	Metabolic Ratio of Accumulation Ratios	
2023-09-29	CDISC-5840	Add	C201464	Term	PKPARMCD	PK Parameters Code	Add new term to existing codelist	- - -	METRAARS	
2023-09-29	CDISC-6178	Add	C78729	Term	SPEC	Specimen	Add new term to existing codelist	- - -	ARTERIAL BLOOD	NCI C-code and NCI Preferred Term being updated from C65859 to C78729 to fix the error in coding. 
2023-09-29	CDISC-5746	Add	C122629	Term	UNIT	Unit	Add new term to existing codelist	- - -	ACTUATION	
2023-09-29	CDISC-5620	Add	C201485	Term	UNIT	Unit	Add new term to existing codelist	- - -	pmol/punch/h	
2023-09-29	CDISC-5763	Add	C201486	Term	UNIT	Unit	Add new term to existing codelist	- - -	(mmHg*min/L)*m2	
2023-09-29	CDISC-5874	Add	C201487	Term	UNIT	Unit	Add new term to existing codelist	- - -	cmH2O/mL/s	
2023-09-29	CDISC-5887	Add	C68906	Term	UNIT	Unit	Add new term to existing codelist	- - -	m2/s	
2023-09-29	CDISC-6178	Remove	C65859	Term	SPEC	Specimen	Remove term entirely from codelist	ARTERIAL BLOOD	- - -	NCI C-code and NCI Preferred Term being updated from C65859 to C78729 to fix the error in coding. 
2023-09-29	N/A	Update	C148551	NCI Preferred Term	FRM	Pharmaceutical Dosage Form	Update NCI Preferred Term	Coated Granule Dosage Form	Coated Granules Dosage Form	
2023-09-29	N/A	Update	C42903	NCI Preferred Term	FRM	Pharmaceutical Dosage Form	Update NCI Preferred Term	Delayed Release Granule Dosage Form	Delayed Release Granules Dosage Form	
2023-09-29	N/A	Update	C42909	NCI Preferred Term	FRM	Pharmaceutical Dosage Form	Update NCI Preferred Term	Effervescent Granule Dosage Form	Effervescent Granules Dosage Form	
2023-09-29	CDISC-5730	Update	C132366	CDISC Synonym	LBTEST	Laboratory Test Name	Add new CDISC Synonym	- - -	Squamous Cells/Total Cells	
2023-09-29	CDISC-6178	Update	C174316	CDISC Definition	LBTEST	Laboratory Test Name	Update CDISC Definition	A relative measurement (ratio or percentage) of the B-lymphocytes to leukocytes in a biological specimen.	A relative measurement (ratio or percentage) of B-lymphocytes to leukocytes in a biological specimen.	
2023-09-29	CDISC-6178	Update	C174316	CDISC Synonym	LBTEST	Laboratory Test Name	Add new CDISC Synonym	- - -	B Cells/Leukocytes	
2023-09-29	CDISC-6178	Update	C174316	CDISC Synonym	LBTEST	Laboratory Test Name	Add new CDISC Synonym	- - -	BLym/Leuk	
2023-09-29	CDISC-5730	Update	C132366	CDISC Synonym	LBTESTCD	Laboratory Test Code	Add new CDISC Synonym	- - -	Squamous Cells/Total Cells	
2023-09-29	CDISC-6178	Update	C174316	CDISC Definition	LBTESTCD	Laboratory Test Code	Update CDISC Definition	A relative measurement (ratio or percentage) of the B-lymphocytes to leukocytes in a biological specimen.	A relative measurement (ratio or percentage) of B-lymphocytes to leukocytes in a biological specimen.	
2023-09-29	CDISC-6178	Update	C174316	CDISC Synonym	LBTESTCD	Laboratory Test Code	Add new CDISC Synonym	- - -	B Cells/Leukocytes	
2023-09-29	CDISC-6178	Update	C174316	CDISC Synonym	LBTESTCD	Laboratory Test Code	Add new CDISC Synonym	- - -	BLym/Leuk	
2023-09-29	N/A	Update	C12228	NCI Preferred Term	LOC	Anatomical Location	Update NCI Preferred Term	Base of the Tongue	Base of Tongue	
2023-09-29	CDISC-6053	Update	C154841	CDISC Definition	PKPARM	PK Parameters	Update CDISC Definition	The total body clearance for intravascular administration divided by the fraction of drug unbound, calculated using the predicted value of the last non-zero concentration.	The total body clearance for intravascular administration divided by the fraction of drug unbound, calculated using the AUCINF based on the predicted value of the last non-zero concentration.	
2023-09-29	CDISC-6053	Update	C154842	CDISC Definition	PKPARM	PK Parameters	Update CDISC Definition	The total body clearance for intravascular administration divided by the fraction of drug unbound, calculated using the observed value of the last non-zero concentration.	The total body clearance for intravascular administration divided by the fraction of drug unbound, calculated using the AUCINF based on the observed value of the last non-zero concentration.	
2023-09-29	CDISC-6053	Update	C85772	CDISC Definition	PKPARM	PK Parameters	Update CDISC Definition	The total body clearance for extravascular administration divided by the fraction of dose absorbed, calculated using the observed value of the last non-zero concentration.	The total body clearance for extravascular administration divided by the fraction of dose absorbed, calculated using the AUCINF based on the observed value of the last non-zero concentration.	
2023-09-29	CDISC-6053	Update	C85773	CDISC Definition	PKPARM	PK Parameters	Update CDISC Definition	The total body clearance for intravascular administration, calculated using the observed value of the last non-zero concentration.	The total body clearance for intravascular administration, calculated using the AUCINF based on the observed value of the last non-zero concentration.	
2023-09-29	CDISC-6053	Update	C85796	CDISC Definition	PKPARM	PK Parameters	Update CDISC Definition	The total body clearance for extravascular administration divided by the fraction of dose absorbed, calculated using the predicted value of the last non-zero concentration.	The total body clearance for extravascular administration divided by the fraction of dose absorbed, calculated using the AUCINF based on the predicted value of the last non-zero concentration.	
2023-09-29	CDISC-6053	Update	C85797	CDISC Definition	PKPARM	PK Parameters	Update CDISC Definition	The total body clearance for intravascular administration, calculated using the predicted value of the last non-zero concentration.	The total body clearance for intravascular administration, calculated using the AUCINF based on the predicted value of the last non-zero concentration.	
2023-09-29	CDISC-6053	Update	C92399	CDISC Definition	PKPARM	PK Parameters	Update CDISC Definition	The total body clearance for extravascular administration divided by the fraction of dose absorbed, calculated using the observed value of the last non-zero concentration, divided by the body mass index.	The total body clearance for extravascular administration divided by the fraction of dose absorbed, calculated using the AUCINF based on the observed value of the last non-zero concentration, divided by the body mass index.	
2023-09-29	CDISC-6053	Update	C92400	CDISC Definition	PKPARM	PK Parameters	Update CDISC Definition	The total body clearance for extravascular administration divided by the fraction of dose absorbed, calculated using the observed value of the last non-zero concentration, divided by the dose.	The total body clearance for extravascular administration divided by the fraction of dose absorbed, calculated using the AUCINF based on the observed value of the last non-zero concentration, divided by the dose.	
2023-09-29	CDISC-6053	Update	C92401	CDISC Definition	PKPARM	PK Parameters	Update CDISC Definition	The total body clearance for extravascular administration divided by the fraction of dose absorbed, calculated using the observed value of the last non-zero concentration, divided by the surface area.	The total body clearance for extravascular administration divided by the fraction of dose absorbed, calculated using the AUCINF based on the observed value of the last non-zero concentration, divided by the surface area.	
2023-09-29	CDISC-6053	Update	C92402	CDISC Definition	PKPARM	PK Parameters	Update CDISC Definition	The total body clearance for extravascular administration divided by the fraction of dose absorbed, calculated using the observed value of the last non-zero concentration, divided by the weight.	The total body clearance for extravascular administration divided by the fraction of dose absorbed, calculated using the AUCINF based on the observed value of the last non-zero concentration, divided by the weight.	
2023-09-29	CDISC-6053	Update	C92403	CDISC Definition	PKPARM	PK Parameters	Update CDISC Definition	The total body clearance for intravascular administration, calculated using the observed value of the last non-zero concentration, divided by the body mass index.	The total body clearance for intravascular administration, calculated using the AUCINF based on the observed value of the last non-zero concentration, divided by the body mass index.	
2023-09-29	CDISC-6053	Update	C92404	CDISC Definition	PKPARM	PK Parameters	Update CDISC Definition	The total body clearance for intravascular administration, calculated using the observed value of the last non-zero concentration, divided by the dose.	The total body clearance for intravascular administration, calculated using the AUCINF based on the observed value of the last non-zero concentration, divided by the dose.	
2023-09-29	CDISC-6053	Update	C92405	CDISC Definition	PKPARM	PK Parameters	Update CDISC Definition	The total body clearance for intravascular administration, calculated using the observed value of the last non-zero concentration, divided by the surface area.	The total body clearance for intravascular administration, calculated using the AUCINF based on the observed value of the last non-zero concentration, divided by the surface area.	
2023-09-29	CDISC-6053	Update	C92406	CDISC Definition	PKPARM	PK Parameters	Update CDISC Definition	The total body clearance for intravascular administration, calculated using the observed value of the last non-zero concentration, divided by the weight.	The total body clearance for intravascular administration, calculated using the AUCINF based on the observed value of the last non-zero concentration, divided by the weight.	
2023-09-29	CDISC-6053	Update	C92417	CDISC Definition	PKPARM	PK Parameters	Update CDISC Definition	The total body clearance for extravascular administration divided by the fraction of dose absorbed, calculated using the predicted value of the last non-zero concentration, divided by body mass index.	The total body clearance for extravascular administration divided by the fraction of dose absorbed, calculated using the AUCINF based on the predicted value of the last non-zero concentration, divided by body mass index.	
2023-09-29	CDISC-6053	Update	C92418	CDISC Definition	PKPARM	PK Parameters	Update CDISC Definition	The total body clearance for extravascular administration divided by the fraction of dose absorbed, calculated using the predicted value of the last non-zero concentration, divided by the dose.	The total body clearance for extravascular administration divided by the fraction of dose absorbed, calculated using the AUCINF based on the predicted value of the last non-zero concentration, divided by the dose.	
2023-09-29	CDISC-6053	Update	C92419	CDISC Definition	PKPARM	PK Parameters	Update CDISC Definition	The total body clearance for extravascular administration divided by the fraction of dose absorbed, calculated using the predicted value of the last non-zero concentration, divided by the surface area.	The total body clearance for extravascular administration divided by the fraction of dose absorbed, calculated using the AUCINF based on the predicted value of the last non-zero concentration, divided by the surface area.	
2023-09-29	CDISC-6053	Update	C92420	CDISC Definition	PKPARM	PK Parameters	Update CDISC Definition	The total body clearance for extravascular administration divided by the fraction of dose absorbed, calculated using the predicted value of the last non-zero concentration, divided by the weight.	The total body clearance for extravascular administration divided by the fraction of dose absorbed, calculated using the AUCINF based on the predicted value of the last non-zero concentration, divided by the weight.	
2023-09-29	CDISC-6053	Update	C92421	CDISC Definition	PKPARM	PK Parameters	Update CDISC Definition	The total body clearance for intravascular administration, calculated using the predicted value of the last non-zero concentration, divided by the body mass index.	The total body clearance for intravascular administration, calculated using the AUCINF based on the predicted value of the last non-zero concentration, divided by the body mass index.	
2023-09-29	CDISC-6053	Update	C92422	CDISC Definition	PKPARM	PK Parameters	Update CDISC Definition	The total body clearance for intravascular administration, calculated using the predicted value of the last non-zero concentration, divided by the dose.	The total body clearance for intravascular administration, calculated using the AUCINF based on the predicted value of the last non-zero concentration, divided by the dose.	
2023-09-29	CDISC-6053	Update	C92423	CDISC Definition	PKPARM	PK Parameters	Update CDISC Definition	The total body clearance for intravascular administration, calculated using the predicted value of the last non-zero concentration, divided by the surface area.	The total body clearance for intravascular administration, calculated using the AUCINF based on the predicted value of the last non-zero concentration, divided by the surface area.	
2023-09-29	CDISC-6053	Update	C92424	CDISC Definition	PKPARM	PK Parameters	Update CDISC Definition	The total body clearance for intravascular administration, calculated using the predicted value of the last non-zero concentration, divided by the weight.	The total body clearance for intravascular administration, calculated using the AUCINF based on the predicted value of the last non-zero concentration, divided by the weight.	
2023-09-29	CDISC-6053	Update	C154841	CDISC Definition	PKPARMCD	PK Parameters Code	Update CDISC Definition	The total body clearance for intravascular administration divided by the fraction of drug unbound, calculated using the predicted value of the last non-zero concentration.	The total body clearance for intravascular administration divided by the fraction of drug unbound, calculated using the AUCINF based on the predicted value of the last non-zero concentration.	
2023-09-29	CDISC-6053	Update	C154842	CDISC Definition	PKPARMCD	PK Parameters Code	Update CDISC Definition	The total body clearance for intravascular administration divided by the fraction of drug unbound, calculated using the observed value of the last non-zero concentration.	The total body clearance for intravascular administration divided by the fraction of drug unbound, calculated using the AUCINF based on the observed value of the last non-zero concentration.	
2023-09-29	CDISC-6053	Update	C85772	CDISC Definition	PKPARMCD	PK Parameters Code	Update CDISC Definition	The total body clearance for extravascular administration divided by the fraction of dose absorbed, calculated using the observed value of the last non-zero concentration.	The total body clearance for extravascular administration divided by the fraction of dose absorbed, calculated using the AUCINF based on the observed value of the last non-zero concentration.	
2023-09-29	CDISC-6053	Update	C85773	CDISC Definition	PKPARMCD	PK Parameters Code	Update CDISC Definition	The total body clearance for intravascular administration, calculated using the observed value of the last non-zero concentration.	The total body clearance for intravascular administration, calculated using the AUCINF based on the observed value of the last non-zero concentration.	
2023-09-29	CDISC-6053	Update	C85796	CDISC Definition	PKPARMCD	PK Parameters Code	Update CDISC Definition	The total body clearance for extravascular administration divided by the fraction of dose absorbed, calculated using the predicted value of the last non-zero concentration.	The total body clearance for extravascular administration divided by the fraction of dose absorbed, calculated using the AUCINF based on the predicted value of the last non-zero concentration.	
2023-09-29	CDISC-6053	Update	C85797	CDISC Definition	PKPARMCD	PK Parameters Code	Update CDISC Definition	The total body clearance for intravascular administration, calculated using the predicted value of the last non-zero concentration.	The total body clearance for intravascular administration, calculated using the AUCINF based on the predicted value of the last non-zero concentration.	
2023-09-29	CDISC-6053	Update	C92399	CDISC Definition	PKPARMCD	PK Parameters Code	Update CDISC Definition	The total body clearance for extravascular administration divided by the fraction of dose absorbed, calculated using the observed value of the last non-zero concentration, divided by the body mass index.	The total body clearance for extravascular administration divided by the fraction of dose absorbed, calculated using the AUCINF based on the observed value of the last non-zero concentration, divided by the body mass index.	
2023-09-29	CDISC-6053	Update	C92400	CDISC Definition	PKPARMCD	PK Parameters Code	Update CDISC Definition	The total body clearance for extravascular administration divided by the fraction of dose absorbed, calculated using the observed value of the last non-zero concentration, divided by the dose.	The total body clearance for extravascular administration divided by the fraction of dose absorbed, calculated using the AUCINF based on the observed value of the last non-zero concentration, divided by the dose.	
2023-09-29	CDISC-6053	Update	C92401	CDISC Definition	PKPARMCD	PK Parameters Code	Update CDISC Definition	The total body clearance for extravascular administration divided by the fraction of dose absorbed, calculated using the observed value of the last non-zero concentration, divided by the surface area.	The total body clearance for extravascular administration divided by the fraction of dose absorbed, calculated using the AUCINF based on the observed value of the last non-zero concentration, divided by the surface area.	
2023-09-29	CDISC-6053	Update	C92402	CDISC Definition	PKPARMCD	PK Parameters Code	Update CDISC Definition	The total body clearance for extravascular administration divided by the fraction of dose absorbed, calculated using the observed value of the last non-zero concentration, divided by the weight.	The total body clearance for extravascular administration divided by the fraction of dose absorbed, calculated using the AUCINF based on the observed value of the last non-zero concentration, divided by the weight.	
2023-09-29	CDISC-6053	Update	C92403	CDISC Definition	PKPARMCD	PK Parameters Code	Update CDISC Definition	The total body clearance for intravascular administration, calculated using the observed value of the last non-zero concentration, divided by the body mass index.	The total body clearance for intravascular administration, calculated using the AUCINF based on the observed value of the last non-zero concentration, divided by the body mass index.	
2023-09-29	CDISC-6053	Update	C92404	CDISC Definition	PKPARMCD	PK Parameters Code	Update CDISC Definition	The total body clearance for intravascular administration, calculated using the observed value of the last non-zero concentration, divided by the dose.	The total body clearance for intravascular administration, calculated using the AUCINF based on the observed value of the last non-zero concentration, divided by the dose.	
2023-09-29	CDISC-6053	Update	C92405	CDISC Definition	PKPARMCD	PK Parameters Code	Update CDISC Definition	The total body clearance for intravascular administration, calculated using the observed value of the last non-zero concentration, divided by the surface area.	The total body clearance for intravascular administration, calculated using the AUCINF based on the observed value of the last non-zero concentration, divided by the surface area.	
2023-09-29	CDISC-6053	Update	C92406	CDISC Definition	PKPARMCD	PK Parameters Code	Update CDISC Definition	The total body clearance for intravascular administration, calculated using the observed value of the last non-zero concentration, divided by the weight.	The total body clearance for intravascular administration, calculated using the AUCINF based on the observed value of the last non-zero concentration, divided by the weight.	
2023-09-29	CDISC-6053	Update	C92417	CDISC Definition	PKPARMCD	PK Parameters Code	Update CDISC Definition	The total body clearance for extravascular administration divided by the fraction of dose absorbed, calculated using the predicted value of the last non-zero concentration, divided by body mass index.	The total body clearance for extravascular administration divided by the fraction of dose absorbed, calculated using the AUCINF based on the predicted value of the last non-zero concentration, divided by body mass index.	
2023-09-29	CDISC-6053	Update	C92418	CDISC Definition	PKPARMCD	PK Parameters Code	Update CDISC Definition	The total body clearance for extravascular administration divided by the fraction of dose absorbed, calculated using the predicted value of the last non-zero concentration, divided by the dose.	The total body clearance for extravascular administration divided by the fraction of dose absorbed, calculated using the AUCINF based on the predicted value of the last non-zero concentration, divided by the dose.	
2023-09-29	CDISC-6053	Update	C92419	CDISC Definition	PKPARMCD	PK Parameters Code	Update CDISC Definition	The total body clearance for extravascular administration divided by the fraction of dose absorbed, calculated using the predicted value of the last non-zero concentration, divided by the surface area.	The total body clearance for extravascular administration divided by the fraction of dose absorbed, calculated using the AUCINF based on the predicted value of the last non-zero concentration, divided by the surface area.	
2023-09-29	CDISC-6053	Update	C92420	CDISC Definition	PKPARMCD	PK Parameters Code	Update CDISC Definition	The total body clearance for extravascular administration divided by the fraction of dose absorbed, calculated using the predicted value of the last non-zero concentration, divided by the weight.	The total body clearance for extravascular administration divided by the fraction of dose absorbed, calculated using the AUCINF based on the predicted value of the last non-zero concentration, divided by the weight.	
2023-09-29	CDISC-6053	Update	C92421	CDISC Definition	PKPARMCD	PK Parameters Code	Update CDISC Definition	The total body clearance for intravascular administration, calculated using the predicted value of the last non-zero concentration, divided by the body mass index.	The total body clearance for intravascular administration, calculated using the AUCINF based on the predicted value of the last non-zero concentration, divided by the body mass index.	
2023-09-29	CDISC-6053	Update	C92422	CDISC Definition	PKPARMCD	PK Parameters Code	Update CDISC Definition	The total body clearance for intravascular administration, calculated using the predicted value of the last non-zero concentration, divided by the dose.	The total body clearance for intravascular administration, calculated using the AUCINF based on the predicted value of the last non-zero concentration, divided by the dose.	
2023-09-29	CDISC-6053	Update	C92423	CDISC Definition	PKPARMCD	PK Parameters Code	Update CDISC Definition	The total body clearance for intravascular administration, calculated using the predicted value of the last non-zero concentration, divided by the surface area.	The total body clearance for intravascular administration, calculated using the AUCINF based on the predicted value of the last non-zero concentration, divided by the surface area.	
2023-09-29	CDISC-6053	Update	C92424	CDISC Definition	PKPARMCD	PK Parameters Code	Update CDISC Definition	The total body clearance for intravascular administration, calculated using the predicted value of the last non-zero concentration, divided by the weight.	The total body clearance for intravascular administration, calculated using the AUCINF based on the predicted value of the last non-zero concentration, divided by the weight.	
2023-09-29	CDISC-5811	Update	C139164	CDISC Synonym	SPEC	Specimen	Add new CDISC Synonym	- - -	Nasal Middle Turbinate	
2023-09-29	CDISC-5991	Update	C70480	CDISC Submission Value	UNIT	Unit	Update CDISC Submission Value	log EID 50/dose	log10 EID 50/dose