Release Date	Request Code	NCIt Code	CDISC Term Type	Change Summary	Original	New
2009-05-01	18854	C74761	Preferred Term	Remove the word 'Ratio' from PT of term 'Albumin/Creatinine Ratio' in SDTM-LBTEST, SDTM-LBTESTCD codelists. Also remove 'Ratio' from SY	PT/SY: Albumin/Creatinine Ratio	PT/SY Albumin/Creatinine
2009-05-01	18855	C35266	Preferred Term	Change C35266 CDISC PT Anisocytosis to C74797 CDISC PT Anisocytes in SDTM-LBTEST, SDTM-LBTESTCD codelists. Code changes also.	C35266 PT: Anisocytosis	C74797 PT: Anisocytes
2009-05-01	18906	C35267	Preferred Term	NCI Code changes from C35267 to C79602 in SDTM-LBTEST, SDTM-LBTESTCD codelists.	C35267 PT: Poikilocytes	C79602 PT: Poikilocytes
2009-05-01	19014	C49686	Definition	Misspelling in Definition for Phase IIa Trial in SDTM-TPHASE codelist.	Def: A clinical research protocol generally refered to as a pilot or feasibility trial that aims to prove the concept of the new intervention in question. (NCI)	Def: A clinical research protocol generally referred to as a pilot or feasibility trial that aims to prove the concept of the new intervention in question. (NCI)
2009-05-01	19016	C49688	Definition	Misspelling in Definition for Phase IIb Trial in SDTM-TPHASE codelist.	Def: A clinical research protocol generally refered to as a well-controlled and pivotal trial that aims to prove the mechanism of action of the new intervention in question. A pivotal study will generally be well-controlled, randomized, of adequate size, and whenever possible, double-blind. (NCI)	Def: A clinical research protocol generally referred to as a well-controlled and pivotal trial that aims to prove the mechanism of action of the new intervention in question. A pivotal study will generally be well-controlled, randomized, of adequate size, and whenever possible, double-blind. (NCI)
2009-05-01	19017	C49399	Definition	Misspelling in Definition for CONGENITAL, FAMILIAL AND GENETIC DISORDERS in SDTM-SOC codelist.	Def: A class of disorders that encompasses conditions resulting from a congenital, familial hereditary trait or genetic abnormality as is manifested by a characterstic set of symptoms and signs. (NCI)	Def: A class of disorders that encompasses conditions resulting from a congenital, familial hereditary trait or genetic abnormality as is manifested by a characteristic set of symptoms and signs. (NCI)
2009-05-01	19018	C49476	Definition	Double 'the' in definition for LOINC. Remove first 'the' for better readability.	Def: Published by the The Regenstrief Institute, the Logical Observation Identifiers Names and Codes covers clinical and clinical laboratory terminology.	Def: Published by The Regenstrief Institute, the Logical Observation Identifiers Names and Codes covers clinical and clinical laboratory terminology.
2009-05-01	19019	C74610	Definition	Misspelling in Definition for Dohle Bodies	Def: A measurement of the Dohle bodie (blue-gray, basophilic, leukocyte inclusions located in the peripheral cytoplasm of neutrophils) in a biological specimen.	Def: A measurement of the Dohle bodies (blue-gray, basophilic, leukocyte inclusions located in the peripheral cytoplasm of neutrophils) in a biological specimen.
2009-05-01	19021	C71032	Definition	Misspelling in Definition for NOTCHED T-WAVES	Def: Any depression occuring in a positive t wave. (NCI)	Def: Any depression occurring in a positive t wave. (NCI)
2009-05-01	19022	C71046	Definition	Misspelling in Definition for BIFASICULAR BLOCK	Def: An electrocardiographic finding comprising right bundle branch block and left anterior fascicular block, or right bundle branch block and left posterior fascicular block. Defects occuring in two of the three divisions of the conduction system of the heart are considered bifascicular blocks. Technically left bundle branch block may be considered a bifascicular block. (NCI)	Def: An electrocardiographic finding comprising right bundle branch block and left anterior fascicular block, or right bundle branch block and left posterior fascicular block. Defects occurring in two of the three divisions of the conduction system of the heart are considered bifascicular blocks. Technically left bundle branch block may be considered a bifascicular block. (NCI)
2009-05-01	19023	C51224	Definition	Add word 'is' between 'generally' and 'at' in CDISC definition of ATRIAL FLUTTER to make it more readable.	Def: An electrocardiographic finding of an organized rhythmic contraction of the atria which generally at a rate of 200-300 beats per minute. (NCI)	Def: An electrocardiographic finding of an organized rhythmic contraction of the atria which is generally at a rate of 200-300 beats per minute. (NCI)
2009-05-01	19025	C44277	Definition	Remove second '(NCI)' from end of CDISC definition for C44277 Degree Fahrenheit in SDTM-UNIT, SDTM-VSRESU codelists.	Def: The Fahrenheit temperature scale is named after the German physicist Gabriel Fahrenheit (1686-1736), who proposed it in 1724. In this scale, the freezing point of water is 32 degrees Fahrenheit and the boiling point is 212 degrees, placing the boiling and melting points of water 180 degrees apart. In this scale a degree Fahrenheit is 5/9ths of a Kelvin (or of a degree Celsius), and minus 40 degrees Fahrenheit is equal to minus 40 degrees Celsius. (NCI)(NCI)	Def: The Fahrenheit temperature scale is named after the German physicist Gabriel Fahrenheit (1686-1736), who proposed it in 1724. In this scale, the freezing point of water is 32 degrees Fahrenheit and the boiling point is 212 degrees, placing the boiling and melting points of water 180 degrees apart. In this scale a degree Fahrenheit is 5/9ths of a Kelvin (or of a degree Celsius), and minus 40 degrees Fahrenheit is equal to minus 40 degrees Celsius. (NCI)
2009-05-01	19026	C51776	Definition	Misspelling in Definition for DIVORCED in SDTM-MARISTAT codelist.	Def: Marrige contract has been declared dissolved and inactive. (HL7)	Def: Marriage contract has been declared dissolved and inactive. (HL7)
2009-05-01	19027	C42546	Definition	Stylistic inconsistency in CDISC definition of C42546 Newton in SDTM-UNIT codelist	Def: A unit of force which, when applied in a vacuum to a body having a mass of one kilogram, causes an acceleration of one meter/sec(2). It is equal to 10E5 dynes.	Def: A unit of force which, when applied in a vacuum to a body having a mass of one kilogram, causes an acceleration of one meter per second squared. It is equal to 10E5 dynes.
2009-05-01	19115	C74688	Preferred Term	Change SDTM-LBTEST PT Barbiturate to Barbiturates. Change synonym as well.	PT/SY: Barbiturate	PT/SY: Barbiturates
2009-05-01	19116	C64470	Definition	Change definition in SDTM-LBTEST, SDTM-LBTESTCD codelists for consistency.	Def: A count of the basophils per unit of a biological specimen.	Def: A measurement of of the basophils per unit of a biological specimen.
2009-05-01	19120	C64471	Definition	Change definition in SDTM-LBTEST, SDTM-LBTESTCD codelists for consistency.	Def: A relative measure (ratio or percentage) of the basophils to leukocytes in a biological specimen.	Def: A relative measurement (ratio or percentage) of the basophils to leukocytes in a biological specimen.
2009-05-01	19123	C64487	Definition	Change definition in SDTM-LBTEST, SDTM-LBTESTCD codelists for consistency.	Def: A relative measure (ratio or percentage) of the blasts to leukocytes in a biological specimen.	Def: A relative measurement (ratio or percentage) of the blasts to leukocytes in a biological specimen.
2009-05-01	19124	C74753	Preferred Term	Remove the word 'Ratio' from PT of term 'BUN/Creatinine Ratio' in SDTM-LBTEST, SDTM-LBTESTCD codelists. Also remove 'Ratio' from SY	PT/SY: BUN/Creatinine Ratio	PT/SY: BUN/Creatinine
2009-05-01	19449	C64549	Definition	Change definition in SDTM-LBTEST, SDTM-LBTESTCD codelists for consistency.	Def: A count of the elliptocytes per unit of a biological specimen.	Def: A measurement of the elliptically shaped erythrocytes in a biological specimen.
2009-05-01	19450	C64550	Definition	Change definition in SDTM-LBTEST, SDTM-LBTESTCD codelists for consistency.	Def: A count of the eosinophils per unit of a biological specimen.	Def: A measurement of the eosinophils per unit of a biological specimen.
2009-05-01	19451	C64604	Definition	Change definition in SDTM-LBTEST, SDTM-LBTESTCD codelists for consistency.	Def: A relative measure (ratio or percentage) of the eosinophils to leukocytes in a biological specimen.	Def: A relative measurement (ratio or percentage) of the eosinophils to leukocytes in a biological specimen.
2009-05-01	19458	C42956, C42945, C42899, C42995, C42926, C42951 	Preferred Term	Make the Submission Value equal to Preferred Term in SDTM-FRM codelist of published spreadsheet; Terms affected are INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION, EXTENDED RELEASE; INJECTION, SOLUTION; INJECTION, SOLUTION, CONCENTRATE; INJECTION, SUSPENSION; INJECTION, SUSPENSION, EXTENDED RELEASE; INJECTION, SUSPENSION, LIPOSOMAL 	- - -	Make column E = F in FRM codelist. Terms affected are INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION, EXTENDED RELEASE; INJECTION, SOLUTION; INJECTION, SOLUTION, CONCENTRATE; INJECTION, SUSPENSION; INJECTION, SUSPENSION, EXTENDED RELEASE; INJECTION, SUSPENSION, LIPOSOMAL.
2009-05-01	19460	C64818	Definition	Change definition in SDTM-LBTEST, SDTM-LBTESTCD codelists for consistency.	Def: A count of the atypical lymphocytes per unit of a biological specimen.	Def: A measurement of the atypical lymphocytes per unit of a biological specimen.
2009-05-01	19461	C64819	Definition	Change definition in SDTM-LBTEST, SDTM-LBTESTCD codelists for consistency.	Def: A relative measure (ratio or percentage) of the atypical lymphocytes to leukocytes in a biological specimen.	Def: A relative measurement (ratio or percentage) of the atypical lymphocytes to leukocytes in a biological specimen.
2009-05-01	19463	C64820	Definition	Change definition in SDTM-LBTEST, SDTM-LBTESTCD codelists for consistency.	Def: A relative measure (ratio or percentage) of the lymphocytes to leukocytes in a biological specimen.	Def: A relative measurement (ratio or percentage) of the lymphocytes to leukocytes in a biological specimen.
2009-05-01	19464	C74654	Definition	Change definition in SDTM-LBTEST, SDTM-LBTESTCD codelists for consistency.	Def: A relative measurement (ratio or percentage) of the reactive lymphocytes (lymphocytes with peripherally clumped chromatin and often deep blue cytoplasm and that appear similar to plasma cells) to all lymphocytes in a biological specimen.	Def: A relative measurement (ratio or percentage) of the reactive lymphocytes (lymphocytes which have become large due to an antigen reaction) to all lymphocytes in a biological specimen.
2009-05-01	19466	C64821	Definition	Change definition in SDTM-LBTEST, SDTM-LBTESTCD codelists for consistency.	Def: A count of the macrocytes per unit of a biological specimen.	Def: A measurement of the macrocytes per unit of a biological specimen.
2009-05-01	19540	C17095	Definition	The definition for Reunion in the SDTM-COUNTRY codelist is incorrect, gramatically.	Def: An Southern Africa, occupying an island in the Indian Ocean, east of Madagascar.	Def: A country in Southern Africa, occupying an island in the Indian Ocean, east of Madagascar.
2009-05-01	19575	C64822	Definition	Change definition in SDTM-LBTEST, SDTM-LBTESTCD codelists for consistency.	Def: A count of the microcytes per unit of a biological specimen.	Def: A measurement of the microcytes per unit of a biological specimen.
2009-05-01	19576	C64823	Definition	Change definition in SDTM-LBTEST, SDTM-LBTESTCD codelists for consistency.	Def: A count of the monocytes per unit of a biological specimen.	Def: A measurement of the monocytes per unit of a biological specimen.
2009-05-01	19577	C64824	Definition	Change definition in SDTM-LBTEST, SDTM-LBTESTCD codelists for consistency.	Def: A relative measure (ratio or percentage) of the monocytes to leukocytes in a biological specimen.	Def: A relative measurement (ratio or percentage) of the monocytes to leukocytes in a biological specimen.
2009-05-01	19578	C74646	Definition	Change definition in SDTM-LBTEST, SDTM-LBTESTCD codelists for consistency.	Def: A relative measurement (ratio or percentage) of monoblast cells to all leukocytes in a biological specimen.	Def: A relative measurement (ratio or percentage) of the monoblasts to leukocytes in a biological specimen.
2009-05-01	19579	C64826	Definition	Change definition in SDTM-LBTEST, SDTM-LBTESTCD codelists for consistency.	Def: A relative measure (ratio or percentage) of the myelocytes to leukocytes in a biological specimen.	Def: A relative measurement (ratio or percentage) of the myelocytes to leukocytes in a biological specimen.
2009-05-01	19580	C63321	Definition	Change definition in SDTM-LBTEST, SDTM-LBTESTCD codelists for consistency.	Def: A count of the neutrophils per unit of a biological specimen.	Def: A measurement of the neutrophils per unit of a biological specimen.
2009-05-01	19581	C64830	Definition	Change definition in SDTM-LBTEST, SDTM-LBTESTCD codelists for consistency.	Def: A count of the banded neutrophils per unit of a biological specimen.	Def: A measurement of the banded neutrophils per unit of a biological specimen.
2009-05-01	19582	C64831	Definition	Change definition in SDTM-LBTEST, SDTM-LBTESTCD codelists for consistency.	Def: A relative measure (ratio or percentage) of the banded neutrophils to leukocytes in a biological specimen.	Def: A relative measurement (ratio or percentage) of the banded neutrophils to leukocytes in a biological specimen.
2009-05-01	19583	C64827	Definition	Change definition in SDTM-LBTEST, SDTM-LBTESTCD codelists for consistency.	Def: The determination of the ratio of neutrophils compared to leukocytes in a blood sample. The measurement may be expressed as a ratio or percentage.	Def: A relative measurement (ratio or percentage) of the neutrophils to leukocytes in a biological specimen.
2009-05-01	19584	C74617	Definition	Change definition in SDTM-LBTEST, SDTM-LBTESTCD codelists for clarity	Def: A measurement of the amount of Pelger Huet anomaly present in a biological specimen.	Def: A measurement of the Pelger Huet Anomaly (nuclei of neutrophils and eosinophils appear rod-like, spherical or dumbbell shaped) in a biological specimen.
2009-05-01	19679	C51951	Definition	Change definition in SDTM-LBTEST, SDTM-LBTESTCD codelists for consistency.	Def: A count of the platelets per unit of a biological specimen.	Def: A measurement of the platelets per unit of a biological specimen.
2009-05-01	19681	C74649	Definition	Aberrant symbol in definition in SDTM-TPHASE codelist: remove right parenthesis.	Def: A relative measurement (ratio or percentage) of the poikilocytes irregularly shaped erythrocytes) to all erythrocytes in a biological specimen.	Def: A relative measurement (ratio or percentage) of the poikilocytes, or irregularly shaped erythrocytes, to all erythrocytes in a biological specimen.
2009-05-01	19682	C51946	Definition	Change definition in SDTM-LBTEST, SDTM-LBTESTCD codelists for consistency.	Def: A count of the total erythrocytes per unit of a biological specimen.	Def: A measurement of the total erythrocytes per unit of a biological specimen.
2009-05-01	19685	C51947	Definition	Change definition in SDTM-LBTEST, SDTM-LBTESTCD codelists for consistency.	Def: A count of the reticulocytes per unit of a biological specimen.	Def: A measurement of the reticulocytes per unit of a biological specimen.
2009-05-01	19686	C64828	Definition	Change definition in SDTM-LBTEST, SDTM-LBTESTCD codelists for consistency.	Def: A relative measure (ratio or percentage) of reticulocytes to erythrocytes in a biological specimen.	Def: A relative measurement (ratio or percentage) of reticulocytes to erythrocytes in a biological specimen.
2009-05-01	19687	C74786	Preferred Term	Correct spelling error - 'e' added to end of Thyroxin in SDTM-LBTEST PT and CDISC SY	PT, SY: Thyroxin, Free	PT, SY: Thyroxine, Free
2009-05-01	19688	C64801	Definition	Change definition in SDTM-LBTEST, SDTM-LBTESTCD codelists for consistency.	Def: A count of dacryocytes in unit of a biological specimen.	Def: A measurement of dacryocytes per unit of a biological specimen.
2009-05-01	19691	C64829	Definition	Change definition in SDTM-LBTEST, SDTM-LBTESTCD codelists for consistency.	Def: A relative measure (ratio or percentage) of prolymphocytes to leukocytes in a biological specimen.	Def:A relative measurement (ratio or percentage) of prolymphocytes to leukocytes in a biological specimen.
2009-05-01	19692	C51949	Definition	Change definition in SDTM-LBTEST, SDTM-LBTESTCD codelists for consistency.	Def: A count of the lymphocytes per unit of a biological specimen.	Def: A measurement of the lymphocytes per unit of a biological specimen.
2009-05-01	19788	C74634	Preferred Term	Bite Cells/Erythrocytes appears twice in LBTEST and LBTESTCD codelist. Remove second one.	- - -	Remove second Bite Cells/Erythrocytes term in LBTEST and LBTESTCD codelist.
2009-05-01	19802	C74894	Preferred Term	Remove the word 'Ratio' from PT of term 'Albumin/Globulin Ratio' in SDTM-LBTEST, SDTM-LBTESTCD codelists. Also remove 'Ratio' from SY	PT/SY: Albumin/Globulin Ratio	PT/SY: Albumin/Globulin
2009-05-01	20004	C49687	Preferred Term	Typo in term Phase IIIaTrial - Space between IIIa and Trial is missing in SDTM-TPHASE codelist.	PT: Phase IIIaTrial	PT: Phase IIIa Trial
2009-05-01	- - -	- - -	- - -	Removal of Columns J (Pre-release/Production) and K (Notes) from SDTM CT spreadsheet	- - -	- - -