Release Date	Request Code	Change Type	NCI Code	CDISC Term Type	CDISC Codelist (Short Name)	CDISC Codelist (Long Name)	Change Summary	Original	New	Change Implementation Instructions
2022-09-30	CDISC-5753	Add	C189351	Term	Protocol Entity Terminology	Protocol Entity Terminology	Add new term to existing codelist	- - -	Study Blinding and Unblinding	
2022-09-30	CDISC-5753	Add	C142408	Term	Study Blinding and Unblinding Attribute Terminology	Study Blinding and Unblinding Attribute Terminology	Add new term to new codelist	- - -	Masked Medication	
2022-09-30	CDISC-5753	Add	C142742	Term	Study Blinding and Unblinding Attribute Terminology	Study Blinding and Unblinding Attribute Terminology	Add new term to new codelist	- - -	Study Unblinding	
2022-09-30	CDISC-5753	Add	C189268	CDISC Codelist	Study Blinding and Unblinding Attribute Terminology	Study Blinding and Unblinding Attribute Terminology	Addition of new codelist	- - -	Study Blinding and Unblinding Attribute Terminology	
2022-09-30	CDISC-5753	Add	C189349	Term	Study Blinding and Unblinding Attribute Terminology	Study Blinding and Unblinding Attribute Terminology	Add new term to new codelist	- - -	Study Blinding Procedure	
2022-09-30	CDISC-5753	Add	C189350	Term	Study Blinding and Unblinding Attribute Terminology	Study Blinding and Unblinding Attribute Terminology	Add new term to new codelist	- - -	Study Unblinding Procedure	
2022-09-30	CDISC-5753	Add	C49068	Term	Study Blinding and Unblinding Attribute Terminology	Study Blinding and Unblinding Attribute Terminology	Add new term to new codelist	- - -	Study Blinding	
2022-09-30	CDISC-5753	Add	C49658	Term	Study Blinding and Unblinding Attribute Terminology	Study Blinding and Unblinding Attribute Terminology	Add new term to new codelist	- - -	Study Blinding Schema	
2022-09-30	CDISC-5753	Add	C15228	Term	TBLIND	Trial Blinding Schema Response	Add new term to new codelist	- - -	DOUBLE BLIND	
2022-09-30	CDISC-5753	Add	C156592	Term	TBLIND	Trial Blinding Schema Response	Add new term to new codelist	- - -	OPEN LABEL TO TREATMENT AND DOUBLE BLIND TO IMP DOSE	
2022-09-30	CDISC-5753	Add	C187674	Term	TBLIND	Trial Blinding Schema Response	Add new term to new codelist	- - -	OBSERVER BLIND	
2022-09-30	CDISC-5753	Add	C28233	Term	TBLIND	Trial Blinding Schema Response	Add new term to new codelist	- - -	SINGLE BLIND	
2022-09-30	CDISC-5753	Add	C49659	Term	TBLIND	Trial Blinding Schema Response	Add new term to new codelist	- - -	OPEN LABEL	
2022-09-30	CDISC-5753	Add	C66735	CDISC Codelist	TBLIND	Trial Blinding Schema Response	Addition of new codelist	- - -	TBLIND	
2022-09-30	CDISC-5753	Remove	C49068	Term	Study Design Attribute Terminology	Study Design Attribute Terminology	Remove term entirely from codelist	Blinding	- - -	C49068 has become an attribute of the new Entity Study Blinding and Unblinding and is therefore no longer represented as an attribute of Study Design entity.
2022-09-30	CDISC-5753	Remove	C49658	Term	Study Design Attribute Terminology	Study Design Attribute Terminology	Remove term entirely from codelist	Trial Blinding Schema	- - -	C49658 has become an attribute of the new Entity Study Blinding and Unblinding and is therefore no longer represented as an attribute of Study Design entity.
2022-09-30	CDISC-5753	Update	C142175	CDISC Synonym	Clinical Study Attribute Terminology	Clinical Study Attribute Terminology	Add new CDISC Synonym	- - -	Study Type Classification	
2022-09-30	CDISC-5753	Update	C112038	CDISC Definition	Clinical Trial Attribute Terminology	Clinical Trial Attribute Terminology	Update CDISC Definition	The condition, disease or disorder that the clinical trial is intended to investigate or address.	The textual representation of the condition, disease or disorder that the clinical trial is intended to investigate or address.	
2022-09-30	CDISC-5753	Update	C112038	CDISC Synonym	Clinical Trial Attribute Terminology	Clinical Trial Attribute Terminology	Add new CDISC Synonym	- - -	Trial Disease/Condition Indication Description	
2022-09-30	CDISC-5753	Update	C48281	CDISC Definition	Clinical Trial Attribute Terminology	Clinical Trial Attribute Terminology	Update CDISC Definition	Any defined stage in the lifecycle of a clinical trial.	A step in the clinical research and development of a therapy from initial clinical trials to post-approval studies. NOTE: Clinical trials are generally categorized into four (sometimes five) phases. A therapeutic intervention may be evaluated in two or more phases simultaneously in different trials, and some trials may overlap two different phases. [21 CFR section 312.21; After ICH Topic E8 NOTE FOR GUIDANCE ON GENERAL CONSIDERATIONS FOR CLINICAL TRIALS, CPMP/ICH/291/95 March 1998]	
2022-09-30	CDISC-5753	Update	C48281	CDISC Synonym	Clinical Trial Attribute Terminology	Clinical Trial Attribute Terminology	Add new CDISC Synonym	- - -	Trial Phase	
2022-09-30	CDISC-5753	Update	C85826	CDISC Definition	Clinical Trial Attribute Terminology	Clinical Trial Attribute Terminology	Update CDISC Definition	The principal purpose of the trial.	A principle objective of the study.	
2022-09-30	CDISC-5753	Update	C85826	CDISC Synonym	Clinical Trial Attribute Terminology	Clinical Trial Attribute Terminology	Add new CDISC Synonym	- - -	Study Primary Objective	
2022-09-30	CDISC-5753	Update	C85827	CDISC Definition	Clinical Trial Attribute Terminology	Clinical Trial Attribute Terminology	Update CDISC Definition	The auxiliary purpose of the trial.	An auxiliary objective of the study.	
2022-09-30	CDISC-5753	Update	C85827	CDISC Synonym	Clinical Trial Attribute Terminology	Clinical Trial Attribute Terminology	Add new CDISC Synonym	- - -	Study Secondary Objective