ACC/AHA Appendix Code ACC/AHA Appendix PT ACC/AHA Concept PT ACC/AHA Header Subset Code ACC/AHA Header PT ACC/AHA Definition NCIt Concept Code NCIt PT NCIt SY NCIt Definition Row C191382 COVID-19 Diagnosis Acute COVID-19 case C171133 COVID-19 Infection 2019-nCoV Infection || COVID-19 || COVID-19 Virus Infection || HCoV-19 Infection || Human Coronavirus 2019 Infection || SARS Coronavirus 2 Infection || SARS-2 Infection || SARS-CoV-2 Disease || SARS-CoV-2 Infection || SARS-CoV2 Disease || SARS-CoV2 Infection || SARS2 Infection || Severe Acute Respiratory Syndrome Coronavirus 2 Infection An acute infection of the respiratory tract that is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Based on currently available information, SARS-CoV-2 is thought to mainly spread from person to person through respiratory droplets. Typically, there is a two- to 14-day incubation period and infected persons can present with no symptoms or mild to severe fever, dry cough, fatigue, and difficulty breathing. Dysgeusia, anosmia, and gastrointestinal and flu-like symptoms have also been reported. Older adults and persons of any age who have serious underlying medical conditions may be of higher risk for severe illness, including secondary infections, respiratory failure, and multi-organ dysfunction. 2 C191382 COVID-19 Diagnosis Confirmed acute COVID-19 case Requires detection of SARS-CoV-2 RNA in a clinical or autopsy specimen using a molecular amplification test (e.g., RT-PCR) C191513 Confirmed Acute COVID-19 Case An acute COVID-19 infection that is verified by detection of SARS-CoV-2 RNA in a clinical or autopsy specimen using a molecular amplification test (e.g., RT-PCR). 3 C191382 COVID-19 Diagnosis Probable acute COVID-19 case Detection of SARS-CoV-2 by antigen test in a respiratory specimen OR Meets clinical criteria and epidemiological linkage criteria for COVID-19 with no confirmatory laboratory testing performed OR A death certificate that lists COVID-19 disease or SARS-CoV-2 as an underlying cause of death or a significant condition contributing to death with no confirmatory laboratory evidence of SARS-CoV-2 C191609 Probable Acute COVID-19 Case A presumed acute COVID-19 infection as evidenced by detection of SARS-CoV-2 by antigen test in a respiratory specimen, by meeting clinical criteria and epidemiological linkage criteria for COVID-19 with no confirmatory laboratory testing performed, or by a death certificate that lists COVID-19 disease or SARS-CoV-2 as an underlying cause of death or a significant condition contributing to death with no confirmatory laboratory evidence of SARS-CoV-2. 4 C191382 COVID-19 Diagnosis Suspected acute COVID-19 case Requires detection of specific antibody in serum, plasma, or whole blood, or detection of specific antigen by immunocytochemistry in an autopsy specimen. C191515 Suspected Acute COVID-19 Case A likely acute COVID-19 infection as evidenced by detection of specific antibody in serum, plasma, or whole blood, or detection of specific antigen by immunocytochemistry in an autopsy specimen. 5 C191382 COVID-19 Diagnosis Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 6 C191382 COVID-19 Diagnosis No COVID-19 test negative and no symptoms to suggest COVID-19 C38757 Negative Finding Negative A finding of normality following an examination or investigation looking for the presence of a microorganism, disease, or condition. 7 C191382 COVID-19 Diagnosis COVID-19 symptom status Presence or absence of symptoms due to acute COVID-19 C191554 COVID-19 Symptom Status The presence or absence of symptoms due to acute COVID-19. 8 C191382 COVID-19 Diagnosis Symptomatic C171549 Symptomatic COVID-19 Infection Laboratory-Confirmed COVID-19 Symptomatic Laboratory-Confirmed || Symptomatic SARS-CoV-2 Infection Laboratory-Confirmed An infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is symptomatic at the time of testing. 9 C191382 COVID-19 Diagnosis Asymptomatic C171547 Asymptomatic COVID-19 Infection Laboratory-Confirmed Asymptomatic SARS-CoV-2 Infection Laboratory-Confirmed || COVID-19 Asymptomatic Laboratory-Confirmed An infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is asymptomatic at the time of testing. 10 C191382 COVID-19 Diagnosis Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 11 C191382 COVID-19 Diagnosis Exposure to infectious COVID-19 case Being in close contact, as defined by the CDC, with a person with a probable or confirmed acute COVID-19 case while the person was in the presumptive infectious period C171571 Exposed to COVID-19 Exposed to SARS-CoV-2 A finding indicating that an individual has been exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). 12 C191382 COVID-19 Diagnosis Yes ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 13 C191382 COVID-19 Diagnosis No C49487 No The non-affirmative response to a question. 14 C191382 COVID-19 Diagnosis Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 15 C191382 COVID-19 Diagnosis Persistently positive SARS-CoV-2 antigen or molecular test Persistently positive virological test (molecular amplification or antigen test) in a patient who is out of the presumptive infectious period of acute COVID-19 C191618 Persistent SARS Coronavirus 2 Positive Persistently SARS Coronavirus 2 Positive An indication that SARS-CoV-2 continued to be detected in a patient's biological samples beyond the presumptive infectious period of acute COVID-19. 16 C191382 COVID-19 Diagnosis Yes ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 17 C191382 COVID-19 Diagnosis No C49487 No The non-affirmative response to a question. 18 C191382 COVID-19 Diagnosis Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 19 C191382 COVID-19 Diagnosis Postacute sequelae of SARS-CoV-2 infection (PASC) Symptoms that significantly impair quality of life, which started during or after probable or confirmed acute COVID-19 and have persisted 4 wk to 3 mo after the initial diagnosis of COVID-19 C179263 Post-Acute Sequelae of COVID-19 Long COVID || Long COVID-19 Syndrome A constellation of signs and symptoms that can persist for weeks or months after acute infection with SARS-CoV-2, or appear weeks after infection. This condition may be characterized by fatigue, shortness of breath, difficulty focusing or concentrating ("brain fog"), sleep disorders, fevers, gastrointestinal symptoms, anxiety, and depression. 20 C191382 COVID-19 Diagnosis Yes ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 21 C191382 COVID-19 Diagnosis No C49487 No The non-affirmative response to a question. 22 C191382 COVID-19 Diagnosis Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 23 C191382 COVID-19 Diagnosis Multisystem inflammatory syndrome in children (MIS-C) The occurrence of fever, laboratory evidence of inflammation, and evidence of clinically severe illness requiring hospitalization with multisystem (greater than or equal to 2) organ involvement AND No plausible alternative diagnoses AND Positive for current or recent SARS-CoV-2 infection by RT-PCR, serology, or antigen test OR exposure to a suspected or confirmed COVID-19 case within 4 wk prior to symptom onset in an individual aged <21 y C172127 Multisystem Inflammatory Syndrome in Children COVID-19-Related Pediatric Inflammatory Multisystem Syndrome || Multisystem Inflammatory Syndrome in Children Associated with COVID-19 || Pediatric Inflammatory Multisystem Syndrome || Pediatric Multi-System Inflammatory Syndrome Potentially Associated with COVID-19 || Pediatric Multisystem Inflammatory Syndrome A rare syndrome temporally associated with COVID-19 in children, marked by persistent fever, inflammation (neutrophilia, elevated C-reactive protein (CRP), and lymphopenia), poor function in one or more organs, and other specific clinical and laboratory features not attributable to other infections. The characteristics of this syndrome appear to be similar to toxic shock syndrome and Kawasaki disease. The following variable signs and symptoms have been most commonly reported to date: coagulopathy, cardiac dysfunction, diarrhea, abdominal distension, other GI symptoms (with some children having positive stool tests for SARS-CoV-2), and acute kidney injury. Respiratory symptoms are not always a prominent feature in these cases. 24 C191382 COVID-19 Diagnosis Yes ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 25 C191382 COVID-19 Diagnosis No C49487 No The non-affirmative response to a question. 26 C191382 COVID-19 Diagnosis Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 27 C191382 COVID-19 Diagnosis Multisystem inflammatory syndrome in adults (MIS-A) A patient aged greater than or equal to 21 y hospitalized for greater than or equal to 24 h, or with an illness resulting in death, who meets the following clinical and laboratory criteria. The patient should not have a more likely alternative diagnosis for the illness (e.g., bacterial sepsis, exacerbation of a chronic medical condition). I. Clinical Criteria: Subjective fever or documented fever (greater than or equal to 38.0 degrees C) for greater than or equal to 24 h prior to hospitalization or within the first 3 d of hospitalization* and at least 3 of the following clinical criteria occurring prior to hospitalization or within the first 3 d of hospitalization*. At least 1 must be a primary clinical criterion: A. Primary clinical criteria: 1. Severe cardiac illness includes myocarditis, pericarditis, coronary artery dilatation/aneurysm, or new-onset right or left ventricular dysfunction (LVEF <50%), 2nd/3rd degree AV block, or ventricular tachycardia. (Note: cardiac arrest alone does not meet this criterion) 2. Rash and nonpurulent conjunctivitis B. Secondary clinical criteria: 1. New-onset neurological signs and symptoms: includes encephalopathy in a patient without prior cognitive impairment, seizures, meningeal signs, or peripheral neuropathy (including Guillain-Barr� syndrome) 2. Shock or hypotension not attributable to medical therapy (e.g., sedation, renal replacement therapy) 3. Abdominal pain, vomiting, or diarrhea 4. Thrombocytopenia (platelet count <150,000/microliter) II. Laboratory evidence: The presence of laboratory evidence of inflammation and SARS-CoV-2 infection. A. Elevated levels of at least 2 of the following: C-reactive protein, ferritin, IL-6, erythrocyte sedimentation rate, procalcitonin B. A positive SARS-CoV-2 test for current or recent infection by RT-PCR, serology, or antigen detection NOTE: *These criteria must be met by the end of hospital day 3, where the date of hospital admission is hospital day 0. C178502 Multisystem Inflammatory Syndrome in Adults A rare syndrome found in adults with positive test results for SARS-CoV-2 by polymerase chain reaction or antibody assays indicating recent infection that is marked by cardiovascular, gastrointestinal, dermatologic, and neurologic symptoms without severe respiratory illness. The most common signs and symptoms that have been reported to date include fever, low blood pressure, abdominal pain, vomiting, diarrhea, neck pain, rash, chest pain, and tiredness not attributable to other infections. 28 C191382 COVID-19 Diagnosis Yes ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 29 C191382 COVID-19 Diagnosis No C49487 No The non-affirmative response to a question. 30 C191382 COVID-19 Diagnosis Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 31 C191382 COVID-19 Diagnosis Prior COVID-19 Prior evidence of COVID-19 in an individual who is no longer in the infectious period C191430 Prior COVID-19 Infection A finding indicating that there is prior evidence of COVID-19 in an individual who is no longer in the infectious period. 32 C191382 COVID-19 Diagnosis Prior COVID-19 without residual sequelae of postacute COVID-19 C191608 Prior COVID-19 Infection Without Residual Sequelae of Post-Acute COVID-19 A finding indicating that there is prior evidence of COVID-19 in an individual who has no residual sequelae of post-acute COVID-19. 33 C191382 COVID-19 Diagnosis Prior COVID-19 with residual sequelae of postacute COVID-19 C191607 Prior COVID-19 Infection With Residual Sequelae of Post-Acute COVID-19 A finding indicating that there is prior evidence of COVID-19 in an individual who has residual sequelae of post-acute COVID-19. 34 C191382 COVID-19 Diagnosis COVID-19 reinfection New discrete episode of acute COVID-19 in person with a prior history of probable/confirmed COVID-19. Other information can provide supporting but not definitive evidence for reinfection, such as culture or subgenomic mRNA analysis (to detect the presence of replication-competent virus) or serology, which could be useful to document a serological response to SARS-CoV-2. The following should be enumerated as a new case: SARS-CoV-2 sequencing results from the new positive specimen and a positive specimen from the most recent previous case demonstrate a different lineage. OR Person was most recently enumerated as a confirmed or probable case with onset date (if available) or first positive specimen collection date for that classification >90 d prior. OR Person was previously reported but not enumerated as a confirmed or probable case (i.e., suspect), but now meets the criteria for a confirmed or probable case. Repeat suspect cases should not be enumerated. C191512 COVID Reinfection A new, discrete episode of acute COVID-19 in an individual with a prior history of probable/confirmed COVID-19. 35 C191382 COVID-19 Diagnosis Yes ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 36 C191382 COVID-19 Diagnosis No C49487 No The non-affirmative response to a question. 37 C191382 COVID-19 Diagnosis Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 38 C191382 COVID-19 Diagnosis Date of acute COVID-19 diagnosis Date that viral testing confirming a diagnosis of acute COVID-19 was obtained C191536 SARS-CoV-2 Diagnosis Date COVID-19 Virus Diagnosis Date || Severe Acute Respiratory Syndrome Coronavirus 2 Diagnosis Date The date that SARS-CoV-2 testing resulted in a diagnosis. 39 C191382 COVID-19 Diagnosis Hospitalization due to COVID-19 Hospitalization due to COVID-19 C191557 Hospitalization due to COVID-19 Admission to a hospital due the health effects caused by COVID-19 infection. 40 C191382 COVID-19 Diagnosis Yes ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 41 C191382 COVID-19 Diagnosis No C49487 No The non-affirmative response to a question. 42 C191382 COVID-19 Diagnosis Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 43 C191382 COVID-19 Diagnosis Hospitalization for any reason with incidental diagnosis of SARS-CoV-2 infection Hospitalization for any non-COVID-19-related indication with incidental diagnosis of SARS-CoV-2 infection C191558 Hospitalization with Incidental Diagnosis of SARS-CoV-2 Infection A hospitalization for a reason not related to COVID-19 infection during which a diagnosis of COVID-19 infection is made. 44 C191382 COVID-19 Diagnosis Yes ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 45 C191382 COVID-19 Diagnosis No C49487 No The non-affirmative response to a question. 46 C191382 COVID-19 Diagnosis Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 47 C191382 COVID-19 Diagnosis Date of first COVID-19-related hospitalization Date that the first COVID-19-related hospitalization occurred C191528 Date of First COVID-19-related Hospitalization The date that the first COVID-19-related hospitalization occurred. 48 C191382 COVID-19 Diagnosis Date of first hospitalization with incidental diagnosis of SARS-CoV-2 infection Date that hospitalization for any non-COVID-19-related indication occurred with incidental first diagnosis of SARS-CoV-2 infection C191529 Date of First Hospitalization with Incidental Diagnosis of SARS-CoV-2 Infection The date of the hospitalization when an incidental finding of SARS-CoV-2 infection was first diagnosed. 49 C191382 COVID-19 Diagnosis Coinfection of COVID-19 with other respiratory infections Other respiratory infection in patient an episode of acute illness caused by SARS-CoV-2 C191500 Coinfection of COVID-19 with Other Respiratory Infections A respiratory infection that is diagnosed concurrently during an episode of acute illness caused by SARS-CoV-2. 50 C191382 COVID-19 Diagnosis Influenza C53482 Influenza An acute viral infection of the respiratory tract, occurring in isolated cases, in epidemics, or in pandemics; it is caused by serologically different strains of viruses (influenzaviruses) designated A, B, and C, has a 3-day incubation period, and usually lasts for 3 to 10 days. It is marked by inflammation of the nasal mucosa, pharynx, and conjunctiva; headache; myalgia; often fever, chills, and prostration; and occasionally involvement of the myocardium or central nervous system. 51 C191382 COVID-19 Diagnosis Other viral infection C3439 Viral Infection Viral Disease || Viral Disorder Any disease caused by a virus. 52 C191382 COVID-19 Diagnosis Bacterial infection C2890 Bacterial Infection Bacterial Disorder An acute infectious disorder that is caused by gram positive or gram negative bacteria; representative examples include pneumococcal, streptococcal, salmonella, and meningeal infections. 53 C191382 COVID-19 Diagnosis Fungal infection C3245 Fungal Infection An infection caused by a fungus. 54 C191382 COVID-19 Diagnosis SARS CoV-2 variant Variant lineage of SARS-CoV-2 C189004 SARS-CoV-2 Variant SARS CoV-2 Variant A genetic variant of SARS CoV-2 as designated by the World Health Organization. 55 C191382 COVID-19 Diagnosis Alpha (B.1.1.7 and Q lineages) C179573 SARS Coronavirus 2 B.1.1.7 B.1.1.7 || SARS Coronavirus 2 Variant Lineage B.1.1.7 || SARS-CoV-2 B.1.1.7 || SARS2 B.1.1.7 A variant lineage of SARS coronavirus 2 where the following variations in the spike glycoprotein sequence have been identified: deletions of the amino acids at positions 69, 70 and 144 and amino acid substitutions N501Y, A570D, D614G, P681H, T716I, S982A and D1118H. The substitutions E484K, S494P and K1191N have also been detected in some but not all sequences for this lineage. 56 C191382 COVID-19 Diagnosis Beta (B.1.351 and descendant lineages) C179575 SARS Coronavirus 2 B.1.351 B.1.351 || SARS Coronavirus 2 Variant Lineage B.1.351 || SARS-CoV-2 B.1.351 || SARS2 B.1.351 A variant lineage of SARS coronavirus 2 where the following variations in the spike glycoprotein sequence have been identified: deletions of the amino acids at positions 241-242 and amino acid substitutions D80A, D215G, K417N, E484K, N501Y, D614G and A701V. 57 C191382 COVID-19 Diagnosis Delta (B.1.617.2 and AY lineages) C179586 SARS Coronavirus 2 B.1.617.2 B.1.617.2 || SARS Coronavirus 2 Variant Lineage B.1.617.2 || SARS-CoV-2 B.1.617.2 || SARS2 B.1.617.2 A variant lineage of SARS coronavirus 2 where the following variations in the spike glycoprotein sequence have been identified: deletions of the amino acids at positions 156 and 157 and amino acid substitutions T19R, R158G, L452R, T478K, D614G, P681R and D950N. The substitution G142D has also been detected in some but not all sequences for this lineage. 58 C191382 COVID-19 Diagnosis Delta (AY1) C180977 SARS Coronavirus 2 AY.1 AY.1 || B.1.617.2.1 || SARS Coronavirus 2 B.1.617.2.1 || SARS Coronavirus 2 Variant Lineage AY.1 || SARS Coronavirus 2 Variant Lineage B.1.617.2.1 || SARS-CoV-2 AY.1 || SARS-CoV-2 B.1617.2.1 || SARS2 AY.1 || SARS2 B.1.617.2.1 A variant lineage of SARS coronavirus 2 where the following variations in the spike glycoprotein sequence have been identified: amino acid substitutions T19R, W258L, K417N, L452R, T478K, D614G, P681R and D950N. 59 C191382 COVID-19 Diagnosis Delta (AY3) C181075 SARS Coronavirus 2 AY.3 AY.3 || B.1.617.2.3 || SARS Coronavirus 2 B.1.617.2.3 || SARS Coronavirus 2 Variant Lineage AY.3 || SARS Coronavirus 2 Variant Lineage B.1.617.2.3 || SARS-CoV-2 AY.3 || SARS-CoV-2 B.1617.2.3 || SARS2 AY.3 || SARS2 B.1.617.2.3 A variant lineage of SARS coronavirus 2 where the following variations in the spike glycoprotein sequence have been identified: deletion of amino acids 157 and 158 and amino acid substitutions T19R, E156G, L452R, T478K, D614G, P681R and D950N. 60 C191382 COVID-19 Diagnosis Gamma (P.1 and descendant lineages) C179599 SARS Coronavirus 2 P.1 B.1.1.28.1 || B.1.128.1 || P.1 || SARS Coronavirus 2 Variant Lineage P.1 || SARS-CoV-2 B.1.128.1 || SARS-CoV-2 P.1 || SARS2 P.1 A variant lineage of SARS coronavirus 2 where the following variations in the spike glycoprotein sequence have been identified: amino acid substitutions L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I and V1176F. 61 C191382 COVID-19 Diagnosis Epsilon (B.1.427 and B.1.429) C179576 SARS Coronavirus 2 B.1.427 B.1.427 || SARS Coronavirus 2 Variant Lineage B.1.427 || SARS-CoV-2 B.1.427 || SARS2 B.1.427 A variant lineage of SARS coronavirus 2 where the following variations in the spike glycoprotein sequence have been identified: amino acid substitutions L452R and D614G. 62 C191382 COVID-19 Diagnosis Epsilon (B.1.429) C179577 SARS Coronavirus 2 B.1.429 B.1.429 || SARS Coronavirus 2 Variant Lineage B.1.429 || SARS-CoV-2 B.1.429 || SARS2 B.1.429 A variant lineage of SARS coronavirus 2 where the following variations in the spike glycoprotein sequence have been identified: amino acid substitutions S13I, W152C, L452R and D614G. 63 C191382 COVID-19 Diagnosis Eta (B.1.525) C179579 SARS Coronavirus 2 B.1.525 B.1.525 || SARS Coronavirus 2 Variant Lineage B.1.525 || SARS-CoV-2 B.1.525 || SARS2 B.1.525 A variant lineage of SARS coronavirus 2 where the following variations in the spike glycoprotein sequence have been identified: deletions of the amino acids at positions 69, 70 and 144 and amino acid substitutions A67V, E484K, D614G, Q677H and F888L. 64 C191382 COVID-19 Diagnosis Iota (B.1.526) C179580 SARS Coronavirus 2 B.1.526 B.1.526 || SARS Coronavirus 2 Variant Lineage B.1.526 || SARS-CoV-2 B.1.526 || SARS2 B.1.526 A variant lineage of SARS coronavirus 2 where the following variations in the spike glycoprotein sequence have been identified: amino acid substitutions T95I, D253G and D614G. The substitutions L5F, S477N, E484K and A701V have also been detected in some but not all sequences for this lineage. 65 C191382 COVID-19 Diagnosis Kappa (B.1.617.1) C179585 SARS Coronavirus 2 B.1.617.1 B.1.617.1 || SARS Coronavirus 2 Variant Lineage B.1.617.1 || SARS-CoV-2 B.1.617.1 || SARS2 B.1.617.1 A variant lineage of SARS coronavirus 2 where the following variations in the spike glycoprotein sequence have been identified: amino acid substitutions G142D, E154K, L452R, E484Q, D614G, P681R and Q1071H. The substitution T95I has also been detected in some but not all sequences for this lineage. 66 C191382 COVID-19 Diagnosis B.1.617.3 C179596 SARS Coronavirus 2 B.1.617.3 B.1.617.3 || SARS Coronavirus 2 Variant Lineage B.1.617.3 || SARS-CoV-2 B.1.617.3 || SARS2 B.1.617.3 A variant lineage of SARS coronavirus 2 where the following variations in the spike glycoprotein sequence have been identified: amino acid substitutions T19R, G142D, L452R, E484Q, D614G, P681R, D950N. 67 C191382 COVID-19 Diagnosis Mu (B.1.621, B.1.621.1) C180913 SARS Coronavirus 2 B.1.621 B.1.621 || SARS Coronavirus 2 Variant Lineage B.1.621 || SARS-CoV-2 B.1.621 || SARS2 B.1.621 A variant lineage of SARS coronavirus 2 where the following variations in the spike glycoprotein sequence have been identified: an amino acid insertion 146N and amino acid substitutions T95I, Y144T, Y145S, R346K, E484K, N501Y, D614G, P681H and D950N. 68 C191382 COVID-19 Diagnosis Mu (B.1.621.1) C188869 SARS Coronavirus 2 B.1.621.1 B.1.621.1 || SARS Coronavirus 2 Variant Lineage B.1.621.1 || SARS-CoV-2 B.1.621.1 || SARS2 B.1.621.1 A variant lineage of SARS coronavirus 2 where the following variations in the spike glycoprotein sequence have been identified: amino acid substitutions T95I, Y144S, Y145N, R346K, E484K, N501Y, D614G, P681H and D950N. 69 C191382 COVID-19 Diagnosis Zeta (P.2) C179598 SARS Coronavirus 2 P.2 B.1.1.28.2 || B.1.128.2 || P.2 || SARS Coronavirus 2 Variant Lineage P.2 || SARS-CoV-2 B.1.128.2 || SARS-CoV-2 P.2 || SARS2 P.2 A variant lineage of SARS coronavirus 2 where the following variations in the spike glycoprotein sequence have been identified: amino acid substitutions E484K, D614G and V1176F. The substitution F565L has also been detected in some but not all sequences for this lineage. 70 C191382 COVID-19 Diagnosis Omicron (B.1.1.529 and BA lineages) C184327 SARS Coronavirus 2 B.1.1.529 B.1.1.529 || SARS Coronavirus 2 Variant Lineage B.1.1.529 || SARS-CoV-2 B.1.1.529 || SARS2 B.1.1.529 A variant lineage of SARS coronavirus 2 where the following variations in the spike glycoprotein sequence have been identified: deletions of the amino acids at positions 69/70, 143/145 and 212 and amino acid substitutions A67V, T95I, G142D, N211I, G339D, S371L, S373P, S375F, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, D796Y, N856K, Q954H, N969K and L981F. 71 C191382 COVID-19 Diagnosis Omicron (BA.1) C187221 SARS Coronavirus 2 BA.1 B.1.1.529.1 || BA.1 || SARS Coronavirus 2 Variant Lineage BA.1 || SARS-CoV-2 BA.1 || SARS2 BA.1 A variant lineage of SARS coronavirus 2 where the following variations in the spike glycoprotein sequence have been identified: deletions of the amino acids at positions 69/70, 143/145 and 212 and amino acid substitutions A67V, T95I, G142D, N211I, G339D, S371L, S373P, S375F, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K and L981F. 72 C191382 COVID-19 Diagnosis Omicron (BA.1,1) C185726 SARS Coronavirus 2 BA.1.1 B.1.1.529.1.1 || BA.1.1 || SARS Coronavirus 2 Variant Lineage BA.1.1 || SARS-CoV-2 BA.1.1 || SARS2 BA.1.1 A variant lineage of SARS coronavirus 2 where the following variations in the spike glycoprotein sequence have been identified: deletions of the amino acids at positions 69/70, 143/145 and 212 and amino acid substitutions A67V, T95I, G142D, N211I, G339D, R346K, S371L, S373P, S375F, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K and L981F. 73 C191382 COVID-19 Diagnosis Omicron (BA.1) C185727 SARS Coronavirus 2 BA.2 B.1.1.529.2 || BA.2 || SARS Coronavirus 2 Variant Lineage BA.2 || SARS-CoV-2 BA.2 || SARS2 BA.2 A variant lineage of SARS coronavirus 2 where the following variations in the spike glycoprotein sequence have been identified: deletions of the amino acids at positions 25/27 and amino acid substitutions T19I, L24S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H and N969K. 74 C191382 COVID-19 Diagnosis Omicron (BA.1) C187220 SARS Coronavirus 2 BA.2.12.1 B.1.1.529.2.12.1 || BA.2.12.1 || SARS Coronavirus 2 Variant Lineage BA.2.12.1 || SARS-CoV-2 BA.2.12.1 || SARS2 BA.2.12.1 A variant lineage of SARS coronavirus 2 where the following variations in the spike glycoprotein sequence have been identified: deletions of the amino acids at positions 25/27 and amino acid substitutions T19I, L24S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452Q, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H and N969K. 75 C191382 COVID-19 Diagnosis Omicron (BA.1) C187219 SARS Coronavirus 2 BA.3 B.1.1.529.3 || BA.3 || SARS Coronavirus 2 Variant Lineage BA.3 || SARS-CoV-2 BA.3 || SARS2 BA.3 A variant lineage of SARS coronavirus 2 where the following variations in the spike glycoprotein sequence have been identified: deletions of the amino acids at positions 69/70, 143/145 and 212 and amino acid substitutions A67V, G142D, N211I, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H and N969K. 76 C191382 COVID-19 Diagnosis Omicron (BA.1) C187218 SARS Coronavirus 2 BA.4 B.1.1.529.4 || BA.4 || SARS Coronavirus 2 Variant Lineage BA.4 || SARS-CoV-2 BA.4 || SARS2 BA.4 A variant lineage of SARS coronavirus 2 where the following variations in the spike glycoprotein sequence have been identified: deletions of the amino acids at positions 25/27 and 69/70 and amino acid substitutions T19I, L24S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H and N969K. This variant has two novel amino acid variations, a D61L substitution in the ORF6 protein and a L11F in the ORF7b protein. 77 C191382 COVID-19 Diagnosis Omicron (BA.1) C187217 SARS Coronavirus 2 BA.5 B.1.1.529.5 || BA.5 || SARS Coronavirus 2 Variant Lineage BA.5 || SARS-CoV-2 BA.5 || SARS2 BA.5 A variant lineage of SARS coronavirus 2 where the following variations in the spike glycoprotein sequence have been identified: deletions of the amino acids at positions 25/27 and 69/70 and amino acid substitutions T19I, L24S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H and N969K. 78 C191382 COVID-19 Diagnosis Other, specify C157106 Specify Other A directive to indicate a response not listed. 79 C191382 COVID-19 Diagnosis Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 80 C191383 COVID-19 Cardiovascular Complications Acute myocardial injury related to acute COVID-19 C191396 Acute Cardiovascular Complications Related to COVID-19 Infection C191419 Acute Myocardial Injury Related to Acute COVID-19 Acute myocardial injury in an individual with probable or confirmed COVID-19 infection and no alternative explanation for acute myocardial injury. 81 C191383 COVID-19 Cardiovascular Complications Acute myocardial injury without ischemia, HF, ventricular dysfunction, or myocarditis C191396 Acute Cardiovascular Complications Related to COVID-19 Infection Acute myocardial injury, without evidence of a newly reduced LVEF or RVEF, HF, cardiogenic shock, myocarditis, or acute ischemia in a patient with probable or confirmed acute COVID-19 C191442 Acute Myocardial Injury without Ischemia, Heart Failure, Ventricular Dysfunction, or Myocarditis Related to COVID-19 Acute myocardial injury, without evidence of acute ischemia, heart failure, a newly reduced left or right ventricular ejection fraction, cardiogenic shock, or myocarditis in a patient with probable or confirmed acute COVID-19. 82 C191383 COVID-19 Cardiovascular Complications Acute myocardial injury with type I myocardial infarction C191396 Acute Cardiovascular Complications Related to COVID-19 Infection Acute myocardial injury with clinical presentation suggestive of type I myocardial infarction with detection of a rise or fall of cardiac troponin values with at least 1 value above the 99th percentile upper reference limit and with at least 1 of the following: 1. Symptoms of acute myocardial ischemia; 2. New ischemic ECG changes; 3. Development of pathological Q waves; 4. Imaging evidence of new loss of viable myocardium or new regional wall motion abnormality in a pattern consistent with an ischemic etiology; 5. Identification of a coronary thrombus by angiography including intracoronary imaging or by autopsy, occurring in a patient with probable or confirmed acute COVID-19 C191441 Acute Myocardial Injury with Type I Myocardial Infarction Related to COVID-19 Acute myocardial injury with clinical presentation suggestive of type I myocardial infarction with detection of a rise or fall of cardiac troponin values with at least one value above the 99th percentile upper reference limit and with at least 1 of the following: 1. Symptoms of acute myocardial ischemia; 2. New ischemic ECG changes; 3. Development of pathological Q waves; 4. Imaging evidence of new loss of viable myocardium or new regional wall motion abnormality in a pattern consistent with an ischemic etiology; 5. Identification of a coronary thrombus by angiography including intracoronary imaging or by autopsy, occurring in a patient with probable or confirmed acute COVID-19. 83 C191383 COVID-19 Cardiovascular Complications Acute myocardial injury with myocarditis C191396 Acute Cardiovascular Complications Related to COVID-19 Infection Acute myocardial injury with clinical, imaging, and or pathology evidence supporting inflammation and myocarditis in a patient with probable or confirmed acute COVID-19 C191439 Acute Myocardial Injury with Myocarditis Related to COVID-19 Acute myocardial injury with clinical, imaging, and or pathology evidence supporting myocarditis in a patient with probable or confirmed acute COVID-19. 84 C191383 COVID-19 Cardiovascular Complications Acute myocardial injury with LV dysfunction C191396 Acute Cardiovascular Complications Related to COVID-19 Infection Acute myocardial injury with evidence of new systolic dysfunction with reduced LVEF (LVEF <50%) in a patient with probable or confirmed acute COVID-19 C191438 Acute Myocardial Injury with Left Ventricular Dysfunction Related to COVID-19 Acute myocardial injury with evidence of new systolic dysfunction with reduced left ventricular ejection (LVEF less than 50%) in a patient with probable or confirmed acute COVID-19. 85 C191383 COVID-19 Cardiovascular Complications Acute myocardial injury with RV dysfunction C191396 Acute Cardiovascular Complications Related to COVID-19 Infection Acute myocardial injury with evidence of newly reduced RV function in a patient with probable or confirmed acute COVID-19 C191440 Acute Myocardial Injury with Right Ventricular Dysfunction Related to COVID-19 Acute myocardial injury with evidence of newly reduced right ventricular function in a patient with probable or confirmed acute COVID-19. 86 C191383 COVID-19 Cardiovascular Complications Acute myocardial injury with HF C191396 Acute Cardiovascular Complications Related to COVID-19 Infection Acute myocardial injury with evidence of new or worsening signs and symptoms of HF in a patient with probable or confirmed acute COVID-19 C191437 Acute Myocardial Injury with Heart Failure Related to COVID-19 Acute myocardial injury with evidence of new or worsening signs and symptoms of heart failure in a patient with probable or confirmed acute COVID-19. 87 C191383 COVID-19 Cardiovascular Complications Acute myocardial injury with cardiogenic shock C191396 Acute Cardiovascular Complications Related to COVID-19 Infection Acute myocardial injury with evidence of cardiogenic shock defined as clinical evidence of low cardiac index (e.g., <2.2 L/min/m2) accompanied by impaired tissue perfusion in a patient with probable or confirmed acute COVID-19 C191436 Acute Myocardial Injury with Cardiogenic Shock Related to COVID-19 Acute myocardial injury with evidence of cardiogenic shock defined as clinical evidence of low cardiac index (e.g., less than 2.2 L/min/m2) accompanied by impaired tissue perfusion in a patient with probable or confirmed acute COVID-19. 88 C191383 COVID-19 Cardiovascular Complications No C191396 Acute Cardiovascular Complications Related to COVID-19 Infection C49487 No The non-affirmative response to a question. 89 C191383 COVID-19 Cardiovascular Complications Unknown C191396 Acute Cardiovascular Complications Related to COVID-19 Infection A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 90 C191383 COVID-19 Cardiovascular Complications Acute heart failure C191396 Acute Cardiovascular Complications Related to COVID-19 Infection HF with new or worsening signs and symptoms in a patient with probable or confirmed acute COVID-19. Acute HF can be in the setting of either a preserved or reduced LVEF. This can be the first presentation of HF, or it can reflect an acute decompensation in a patient with history of chronic HF. C191556 Acute Heart Failure Related to COVID-19 New or worsening signs of heart failure in a patient with probable or confirmed acute COVID-19. This can be the first presentation or it can reflect an acute decompensation in a patient with history of chronic heart failure. 91 C191383 COVID-19 Cardiovascular Complications Yes C191396 Acute Cardiovascular Complications Related to COVID-19 Infection ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 92 C191383 COVID-19 Cardiovascular Complications No C191396 Acute Cardiovascular Complications Related to COVID-19 Infection C49487 No The non-affirmative response to a question. 93 C191383 COVID-19 Cardiovascular Complications Unknown C191396 Acute Cardiovascular Complications Related to COVID-19 Infection A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 94 C191383 COVID-19 Cardiovascular Complications Acute pericarditis C191396 Acute Cardiovascular Complications Related to COVID-19 Infection Inflammatory process involving the pericardium, can occur with or without the new development of a pericardial effusion, in a patient with probable or confirmed acute COVID-19 C191443 Acute Pericarditis Related to COVID-19 Acute pericarditis in a patient with probable or confirmed acute COVID-19. 95 C191383 COVID-19 Cardiovascular Complications Yes C191396 Acute Cardiovascular Complications Related to COVID-19 Infection ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 96 C191383 COVID-19 Cardiovascular Complications No C191396 Acute Cardiovascular Complications Related to COVID-19 Infection C49487 No The non-affirmative response to a question. 97 C191383 COVID-19 Cardiovascular Complications Unknown C191396 Acute Cardiovascular Complications Related to COVID-19 Infection A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 98 C191383 COVID-19 Cardiovascular Complications Pericardial effusion C191396 Acute Cardiovascular Complications Related to COVID-19 Infection Inflammatory process involving the pericardium with the new development of a pericardial effusion in a patient with probable or confirmed acute COVID-19 C191594 Pericardial Effusion Related to COVID-19 Pericardial effusion in a patient with probable or confirmed acute COVID-19. 99 C191383 COVID-19 Cardiovascular Complications Yes C191396 Acute Cardiovascular Complications Related to COVID-19 Infection ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 100 C191383 COVID-19 Cardiovascular Complications No C191396 Acute Cardiovascular Complications Related to COVID-19 Infection C49487 No The non-affirmative response to a question. 101 C191383 COVID-19 Cardiovascular Complications Unknown C191396 Acute Cardiovascular Complications Related to COVID-19 Infection A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 102 C191383 COVID-19 Cardiovascular Complications Sustained ventricular arrhythmia C191396 Acute Cardiovascular Complications Related to COVID-19 Infection Sustained ventricular tachycardia (greater than or equal to 30 s or requiring DCCV) or ventricular fibrillation in a patient with probable or confirmed acute COVID-19 C191643 Sustained Ventricular Arrhythmia Related to COVID-19 Ventricular tachycardia or ventricular fibrillation lasting greater than or equal to 30 seconds, or requiring direct current cardioversion (DCCV) in a patient with probable or confirmed acute COVID-19. 103 C191383 COVID-19 Cardiovascular Complications Yes C191396 Acute Cardiovascular Complications Related to COVID-19 Infection ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 104 C191383 COVID-19 Cardiovascular Complications No C191396 Acute Cardiovascular Complications Related to COVID-19 Infection C49487 No The non-affirmative response to a question. 105 C191383 COVID-19 Cardiovascular Complications Unknown C191396 Acute Cardiovascular Complications Related to COVID-19 Infection A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 106 C191383 COVID-19 Cardiovascular Complications New-onset AF C191396 Acute Cardiovascular Complications Related to COVID-19 Infection Newly occurring AF in a patient with probable or confirmed acute COVID-19, further categorized as: 1) first detected AF, 2) paroxysmal AF: AF that is self-terminating within 7 d of recognized onset, 3) persistent AF: AF that is not self-terminating within 7 d C191454 New Onset Atrial Fibrillation Related to COVID-19 Newly occurring atrial fibrillation (AF) in a patient with probable or confirmed acute COVID-19. It is further categorized as first detected AF, paroxysmal AF (self-terminating within seven days of recognized onset), or persistent AF (not self-terminating within seven days). 107 C191383 COVID-19 Cardiovascular Complications Yes C191396 Acute Cardiovascular Complications Related to COVID-19 Infection ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 108 C191383 COVID-19 Cardiovascular Complications No C191396 Acute Cardiovascular Complications Related to COVID-19 Infection C49487 No The non-affirmative response to a question. 109 C191383 COVID-19 Cardiovascular Complications Unknown C191396 Acute Cardiovascular Complications Related to COVID-19 Infection A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 110 C191383 COVID-19 Cardiovascular Complications New-onset atrial flutter C191396 Acute Cardiovascular Complications Related to COVID-19 Infection Newly occurring atrial flutter in a patient with probable or confirmed acute COVID-19 C191456 New Onset Atrial Flutter Related to COVID-19 Newly occurring atrial flutter in a patient with probable or confirmed acute COVID-19. 111 C191383 COVID-19 Cardiovascular Complications Yes C191396 Acute Cardiovascular Complications Related to COVID-19 Infection ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 112 C191383 COVID-19 Cardiovascular Complications No C191396 Acute Cardiovascular Complications Related to COVID-19 Infection C49487 No The non-affirmative response to a question. 113 C191383 COVID-19 Cardiovascular Complications Unknown C191396 Acute Cardiovascular Complications Related to COVID-19 Infection A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 114 C191383 COVID-19 Cardiovascular Complications Sustained atrial tachyarrhythmia other than AF or atrial flutter C191396 Acute Cardiovascular Complications Related to COVID-19 Infection Other types of supraventricular tachycardia, including AV nodal reentry, orthodromic re-entrant tachycardia, multifocal atrial tachycardia, other atrial tachycardia, in a patient with probable or confirmed acute COVID-19 C191631 Sustained Atrial Tachyarrhythmia Related to COVID-19 other than Atrial Fibrillation or Atrial Flutter A supraventricular tachycardia, including AV nodal re-entry, orthodromic re-entrant tachycardia, multifocal atrial tachycardia, other atrial tachycardia that lasts more then 30 seconds in a patient with probable or confirmed acute COVID-19. 115 C191383 COVID-19 Cardiovascular Complications Yes C191396 Acute Cardiovascular Complications Related to COVID-19 Infection ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 116 C191383 COVID-19 Cardiovascular Complications No C191396 Acute Cardiovascular Complications Related to COVID-19 Infection C49487 No The non-affirmative response to a question. 117 C191383 COVID-19 Cardiovascular Complications Unknown C191396 Acute Cardiovascular Complications Related to COVID-19 Infection A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 118 C191383 COVID-19 Cardiovascular Complications Bradyarrhythmia requiring temporary or permanent pacing C191396 Acute Cardiovascular Complications Related to COVID-19 Infection Bradycardia (ventricular rate <60 bpm) that is symptomatic reflecting signs of hypoperfusion and that requires temporary or permanent pacemaker intervention in a patient with probable or confirmed acute COVID-19 C191452 Bradyarrhythmia Related to COVID-19 Requiring Temporary or Permanent Pacing Bradycardia (ventricular rate less than 60 bpm) showing signs of hypoperfusion and that requires temporary or permanent pacemaker intervention in a patient with probable or confirmed acute COVID-19. 119 C191383 COVID-19 Cardiovascular Complications Yes C191396 Acute Cardiovascular Complications Related to COVID-19 Infection ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 120 C191383 COVID-19 Cardiovascular Complications No C191396 Acute Cardiovascular Complications Related to COVID-19 Infection C49487 No The non-affirmative response to a question. 121 C191383 COVID-19 Cardiovascular Complications Unknown C191396 Acute Cardiovascular Complications Related to COVID-19 Infection A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 122 C191383 COVID-19 Cardiovascular Complications Deep venous thrombosis C191396 Acute Cardiovascular Complications Related to COVID-19 Infection Thrombus formation within deep veins in a patient with probable or confirmed acute COVID-19 C191541 Deep Venous Thrombosis Related to COVID-19 DVT Related to COVID-19 Deep vein thrombosis in a patient with probable or confirmed acute COVID-19. 123 C191383 COVID-19 Cardiovascular Complications Yes C191396 Acute Cardiovascular Complications Related to COVID-19 Infection ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 124 C191383 COVID-19 Cardiovascular Complications No C191396 Acute Cardiovascular Complications Related to COVID-19 Infection C49487 No The non-affirmative response to a question. 125 C191383 COVID-19 Cardiovascular Complications Unknown C191396 Acute Cardiovascular Complications Related to COVID-19 Infection A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 126 C191383 COVID-19 Cardiovascular Complications Pulmonary embolus C191396 Acute Cardiovascular Complications Related to COVID-19 Infection Thrombus formation or lodging in an artery in the lung in a patient with probable or confirmed acute COVID-19 C191612 Pulmonary Embolism Related to COVID-19 Pulmonary embolism in a patient with probable or confirmed acute COVID-19. 127 C191383 COVID-19 Cardiovascular Complications Yes C191396 Acute Cardiovascular Complications Related to COVID-19 Infection ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 128 C191383 COVID-19 Cardiovascular Complications No C191396 Acute Cardiovascular Complications Related to COVID-19 Infection C49487 No The non-affirmative response to a question. 129 C191383 COVID-19 Cardiovascular Complications Unknown C191396 Acute Cardiovascular Complications Related to COVID-19 Infection A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 130 C191383 COVID-19 Cardiovascular Complications Intracardiac thrombus C191396 Acute Cardiovascular Complications Related to COVID-19 Infection Thrombus formation in the left or right ventricle or atria of the heart in a patient with probable or confirmed acute COVID-19 C191457 Intracardiac Thrombus Related to COVID-19 Thrombus formation in the chambers of the heart in a patient with probable or confirmed acute COVID-19. 131 C191383 COVID-19 Cardiovascular Complications Yes C191396 Acute Cardiovascular Complications Related to COVID-19 Infection ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 132 C191383 COVID-19 Cardiovascular Complications No C191396 Acute Cardiovascular Complications Related to COVID-19 Infection C49487 No The non-affirmative response to a question. 133 C191383 COVID-19 Cardiovascular Complications Unknown C191396 Acute Cardiovascular Complications Related to COVID-19 Infection A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 134 C191383 COVID-19 Cardiovascular Complications Acute ischemic limb C191396 Acute Cardiovascular Complications Related to COVID-19 Infection Acute decrease in limb perfusion, usually producing new or worsening symptoms or signs, and often threatening limb viability or resulting in limb amputation in a patient with probable or confirmed acute COVID-19 C191596 Acute Ischemic Limb Related to COVID-19 A sudden or severe decrease in limb perfusion in a patient with probable or confirmed acute COVID-19, usually producing new or worsening symptoms or signs, and often threatening limb viability or resulting in limb amputation. 135 C191383 COVID-19 Cardiovascular Complications Yes C191396 Acute Cardiovascular Complications Related to COVID-19 Infection ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 136 C191383 COVID-19 Cardiovascular Complications No C191396 Acute Cardiovascular Complications Related to COVID-19 Infection C49487 No The non-affirmative response to a question. 137 C191383 COVID-19 Cardiovascular Complications Unknown C191396 Acute Cardiovascular Complications Related to COVID-19 Infection A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 138 C191383 COVID-19 Cardiovascular Complications Sudden cardiac death with ROSC C191396 Acute Cardiovascular Complications Related to COVID-19 Infection Unexpected death caused by sudden cardiac arrest with asystole, pulseless electrical activity, sustained ventricular tachycardia, or ventricular fibrillation with successful ROSC in a patient with probable or confirmed acute COVID-19 C191627 Sudden Cardiac Death with Return of Spontaneous Circulation Related to COVID-19 Unexpected death caused by sudden cardiac arrest with asystole, pulseless electrical activity, sustained ventricular tachycardia, or ventricular fibrillation in a patient with probable or confirmed acute COVID-19 despite successful return of spontaneous circulation (ROSC). 139 C191383 COVID-19 Cardiovascular Complications Yes C191396 Acute Cardiovascular Complications Related to COVID-19 Infection ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 140 C191383 COVID-19 Cardiovascular Complications No C191396 Acute Cardiovascular Complications Related to COVID-19 Infection C49487 No The non-affirmative response to a question. 141 C191383 COVID-19 Cardiovascular Complications Unknown C191396 Acute Cardiovascular Complications Related to COVID-19 Infection A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 142 C191383 COVID-19 Cardiovascular Complications Cardiogenic shock with or without comorbid distributive shock C191396 Acute Cardiovascular Complications Related to COVID-19 Infection Clinical evidence of low cardiac index (e.g., <2.2 L/min/m2) accompanied by impaired tissue perfusion in a patient with probable or confirmed acute COVID-19 C191420 Cardiogenic Shock Related to COVID-19 Cardiogenic shock in a patient with probable or confirmed acute COVID-19. 143 C191383 COVID-19 Cardiovascular Complications Stage A C191396 Acute Cardiovascular Complications Related to COVID-19 Infection At risk: A patient who is not currently experiencing signs or symptoms of cardiogenic shock but is at risk for its development. These patients may include those with large acute myocardial infarction or prior infarction, acute or acute on chronic HF symptoms. C191473 Cardiogenic Shock Stage A Related to COVID-19 Clinical signs of warmth and perfusion without volume overload or hypoperfusion and with a normal cardiac index in a patient with probable or confirmed acute COVID-19 that is not currently experiencing signs or symptoms of cardiogenic shock but is at risk for its development. These patients may include those with large acute myocardial infarction or prior infarction, or those with acute or acute on chronic heart failure symptoms. 144 C191383 COVID-19 Cardiovascular Complications Stage B C191396 Acute Cardiovascular Complications Related to COVID-19 Infection Beginning cardiogenic shock: A patient who has clinical evidence of relative hypotension or tachycardia without hypoperfusion C191474 Cardiogenic Shock Stage B Related to COVID-19 Clinical signs of shock or compensated shock in a patient with probable or confirmed acute COVID-19 wherein they may be volume overloaded, tachycardic, and/or hypotensive but no evidence of hypoperfusion on physical exam or laboratory studies. 145 C191383 COVID-19 Cardiovascular Complications Stage C C191396 Acute Cardiovascular Complications Related to COVID-19 Infection Classic cardiogenic shock: A patient that manifests with hypoperfusion that requires intervention (inotrope, pressor or mechanical support, including ECMO) beyond volume resuscitation to restore perfusion. These patients typically present with relative hypotension. C191475 Cardiogenic Shock Stage C Related to COVID-19 Clinical signs of cardiogenic shock with clinical evidence of hypotension and hypoperfusion (cold and wet) on physical examination that requires intervention (inotrope, pressor or mechanical support, including extracorporeal membrane oxygenation (ECMO)) beyond volume resuscitation to restore normal perfusion in a patient with probable or confirmed acute COVID-19. Invasive hemodynamics may demonstrate the classic depressed cardiac index associated with cardiogenic shock. 146 C191383 COVID-19 Cardiovascular Complications Stage D C191396 Acute Cardiovascular Complications Related to COVID-19 Infection Deteriorating/doom: A patient that is similar to category C but is getting worse. They have failure to respond to initial interventions. C191476 Cardiogenic Shock Stage D Related to COVID-19 Clinical signs of deteriorating cardiogenic shock in a patient with probable or confirmed acute COVID-19. Failure to respond to initial interventions to restore adequate perfusion after 30 minutes. Further more intensive therapies are required, including the addition of mechanical circulatory support. 147 C191383 COVID-19 Cardiovascular Complications Stage E C191396 Acute Cardiovascular Complications Related to COVID-19 Infection Extremis: A patient that is experiencing cardiac arrest with ongoing CPR or ECMO, being supported by multiple interventions C191477 Cardiogenic Shock Stage E Related to COVID-19 Clinical signs of extremis in a patient with cardiogenic shock and probable or confirmed acute COVID-19. Highly unstable, often with circulatory collapse and/or refractory cardiac arrest with ongoing cardiopulmonary resuscitation (CPR). They are being supported by multiple simultaneous acute interventions including extracorporeal membrane oxygenation (ECMO)-facilitated CPR (eCPR). 148 C191383 COVID-19 Cardiovascular Complications No C191396 Acute Cardiovascular Complications Related to COVID-19 Infection C49487 No The non-affirmative response to a question. 149 C191383 COVID-19 Cardiovascular Complications Unknown C191396 Acute Cardiovascular Complications Related to COVID-19 Infection A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 150 C191383 COVID-19 Cardiovascular Complications Acute stroke C191396 Acute Cardiovascular Complications Related to COVID-19 Infection An acute neurological deficit attributed to an acute focal injury of the central nervous system by a vascular cause in a patient with probable or confirmed acute COVID-19, accompanied with neuropathological, neuroimaging, or clinical evidence of permanent injury C191520 Acute Stroke Related to COVID-19 The sudden or severe onset of neurological deficit(s) attributable to an acute focal vascular injury of the central nervous system in a patient with probable or confirmed acute COVID-19. 151 C191383 COVID-19 Cardiovascular Complications Acute ischemic stroke || Ischemic stroke C191396 Acute Cardiovascular Complications Related to COVID-19 Infection Acute onset of neurological deficits resulting from a loss of blood supply to brain tissue in an area of arterial distribution. C95802 Ischemic Stroke Ischemic Cerebrovascular Accident An acute episode of focal cerebral, spinal, or retinal dysfunction caused by infarction of brain tissue. 152 C191383 COVID-19 Cardiovascular Complications Intracerebral hemorrhage C191396 Acute Cardiovascular Complications Related to COVID-19 Infection Rapidly developing clinical signs of neurological dysfunction attributable to a focal collection of blood within the brain parenchyma or ventricular system that is not caused by trauma C50485 Cerebral Hemorrhage Intracerebral Hemorrhage || Parenchymatous Hemorrhage Bleeding within the cerebrum. 153 C191383 COVID-19 Cardiovascular Complications Subarachnoid hemorrhage C191396 Acute Cardiovascular Complications Related to COVID-19 Infection Rapidly developing signs of neurological dysfunction or headache because of bleeding into the subarachnoid space (the space between the arachnoid membrane and the pia mater of the brain or spinal cord), which is not caused by trauma C50757 Subarachnoid Hemorrhage Intracranial hemorrhage into the subarachnoid space. 154 C191383 COVID-19 Cardiovascular Complications Epidural hemorrhage C191396 Acute Cardiovascular Complications Related to COVID-19 Infection Intracranial hemorrhage into the epidural space C50555 Epidural Hemorrhage Extradural Hemorrhage Intracranial hemorrhage into the epidural space. 155 C191383 COVID-19 Cardiovascular Complications Subdural hemorrhage C191396 Acute Cardiovascular Complications Related to COVID-19 Infection Bleeding between the dura mater and the brain, usually secondary to a tear of the bridging vein C50759 Subdural Hemorrhage Bleeding between the dura mater and the brain, usually secondary to a tear of the bridging vein. 156 C191383 COVID-19 Cardiovascular Complications Cerebral venous sinus thrombosis C191396 Acute Cardiovascular Complications Related to COVID-19 Infection Stroke because of thrombosis of a cerebral venous structure C116715 Venous Stroke Ischemic or hemorrhagic stroke resulting from cerebral venous thrombosis. 157 C191383 COVID-19 Cardiovascular Complications Stroke || Stroke not otherwise specified C191396 Acute Cardiovascular Complications Related to COVID-19 Infection An episode of acute neurological dysfunction presumed to be caused by ischemia or hemorrhage, persisting greater than or equal to 24 h or until death but without sufficient evidence to be classified as one of the above C3390 Stroke Cerebrovascular Accident || Stroke Syndrome A sudden loss of neurological function secondary to hemorrhage or ischemia in the brain parenchyma due to a vascular event. 158 C191383 COVID-19 Cardiovascular Complications No C191396 Acute Cardiovascular Complications Related to COVID-19 Infection C49487 No The non-affirmative response to a question. 159 C191383 COVID-19 Cardiovascular Complications Unknown C191396 Acute Cardiovascular Complications Related to COVID-19 Infection A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 160 C191383 COVID-19 Cardiovascular Complications Transient ischemic attack C191396 Acute Cardiovascular Complications Related to COVID-19 Infection A brief episode of neurological dysfunction, caused by focal brain or retinal ischemia without imaging evidence of acute infarction C50781 Transient Ischemic Attack A brief attack (from a few minutes to an hour) of cerebral dysfunction of vascular origin, with no persistent neurological deficit. 161 C191383 COVID-19 Cardiovascular Complications Yes C191396 Acute Cardiovascular Complications Related to COVID-19 Infection ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 162 C191383 COVID-19 Cardiovascular Complications No C191396 Acute Cardiovascular Complications Related to COVID-19 Infection C49487 No The non-affirmative response to a question. 163 C191383 COVID-19 Cardiovascular Complications Unknown C191396 Acute Cardiovascular Complications Related to COVID-19 Infection A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 164 C191383 COVID-19 Cardiovascular Complications Left ventricular thrombus C191396 Acute Cardiovascular Complications Related to COVID-19 Infection New diagnosis of left ventricular thrombus in a patient with probable or confirmed acute COVID-19 C191458 Left Ventricular Thrombus Related to COVID-19 A blood clot that has formed in the left ventricle of the heart in a patient with probable or confirmed acute COVID-19. 165 C191383 COVID-19 Cardiovascular Complications Yes C191396 Acute Cardiovascular Complications Related to COVID-19 Infection ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 166 C191383 COVID-19 Cardiovascular Complications No C191396 Acute Cardiovascular Complications Related to COVID-19 Infection C49487 No The non-affirmative response to a question. 167 C191383 COVID-19 Cardiovascular Complications Unknown C191396 Acute Cardiovascular Complications Related to COVID-19 Infection A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 168 C191383 COVID-19 Cardiovascular Complications Coronary ectasia C191396 Acute Cardiovascular Complications Related to COVID-19 Infection Diffuse dilation of coronary artery segment (greater than or equal to 1.5' the adjacent normal segment) in a patient with probable or confirmed acute COVID-19 C191509 Coronary Artery Ectasia Related to COVID-19 Coronary artery ectasia in a patient with probable or confirmed acute COVID-19. 169 C191383 COVID-19 Cardiovascular Complications Yes C191396 Acute Cardiovascular Complications Related to COVID-19 Infection ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 170 C191383 COVID-19 Cardiovascular Complications No C191396 Acute Cardiovascular Complications Related to COVID-19 Infection C49487 No The non-affirmative response to a question. 171 C191383 COVID-19 Cardiovascular Complications Unknown C191396 Acute Cardiovascular Complications Related to COVID-19 Infection A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 172 C191383 COVID-19 Cardiovascular Complications Coronary artery aneurysm C191396 Acute Cardiovascular Complications Related to COVID-19 Infection Focal dilation of a coronary artery (greater than or equal to 1.5' the adjacent normal segment) in a patient with probable or confirmed acute COVID-19 C191502 Coronary Artery Aneurysm Related to COVID-19 Coronary artery aneurysm in a patient with probable or confirmed acute COVID-19. 173 C191383 COVID-19 Cardiovascular Complications Yes C191396 Acute Cardiovascular Complications Related to COVID-19 Infection ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 174 C191383 COVID-19 Cardiovascular Complications No C191396 Acute Cardiovascular Complications Related to COVID-19 Infection C49487 No The non-affirmative response to a question. 175 C191383 COVID-19 Cardiovascular Complications Unknown C191396 Acute Cardiovascular Complications Related to COVID-19 Infection A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 176 C191383 COVID-19 Cardiovascular Complications Microvascular thrombosis C191396 Acute Cardiovascular Complications Related to COVID-19 Infection Blood clotting that is occurring in small blood vessels in the body in a patient with probable or confirmed acute COVID-19 C191642 Microvascular Thrombosis Related to COVID-19 Blood clot formation in the small blood vessels of the body in a patient with probable or confirmed acute COVID-19. 177 C191383 COVID-19 Cardiovascular Complications Yes C191396 Acute Cardiovascular Complications Related to COVID-19 Infection ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 178 C191383 COVID-19 Cardiovascular Complications No C191396 Acute Cardiovascular Complications Related to COVID-19 Infection C49487 No The non-affirmative response to a question. 179 C191383 COVID-19 Cardiovascular Complications Unknown C191396 Acute Cardiovascular Complications Related to COVID-19 Infection A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 180 C191383 COVID-19 Cardiovascular Complications Thrombophilia C191396 Acute Cardiovascular Complications Related to COVID-19 Infection A condition characterized by an abnormally high level of thrombi. Causes include thrombotic thrombocytopenic purpura, disseminated intravascular coagulation, bone marrow disorders, and antiphospholipid antibody syndrome in a patient with probable or confirmed acute COVID-19. C191638 Thrombophilia Related to COVID-19 Thrombophilia in a patient with probable or confirmed acute COVID-19. 181 C191383 COVID-19 Cardiovascular Complications Yes C191396 Acute Cardiovascular Complications Related to COVID-19 Infection ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 182 C191383 COVID-19 Cardiovascular Complications No C191396 Acute Cardiovascular Complications Related to COVID-19 Infection C49487 No The non-affirmative response to a question. 183 C191383 COVID-19 Cardiovascular Complications Unknown C191396 Acute Cardiovascular Complications Related to COVID-19 Infection A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 184 C191383 COVID-19 Cardiovascular Complications Cardiovascular adverse events related to medications aimed at COVID-19 C191396 Acute Cardiovascular Complications Related to COVID-19 Infection Cardiovascular adverse events attributable to or associated with medications used for COVID-19 C191447 Cardiovascular Adverse Events Related to Medications Aimed at COVID-19 A cardiovascular adverse event that is attributable to or associated with medications used to treat COVID-19. 185 C191383 COVID-19 Cardiovascular Complications Arrhythmia C191396 Acute Cardiovascular Complications Related to COVID-19 Infection C2881 Arrhythmia Cardiac Arrhythmia Any variation from the normal rate or rhythm (which may include the origin of the impulse and/or its subsequent propagation) in the heart. 186 C191383 COVID-19 Cardiovascular Complications Coronary artery disorder C191396 Acute Cardiovascular Complications Related to COVID-19 Infection C26732 Coronary Artery Disease Coronary Disease Narrowing of the coronary arteries due to fatty deposits inside the arterial walls. The diagnostic criteria may include documented history of any of the following: documented coronary artery stenosis greater than or equal to 50% (by cardiac catheterization or other modality of direct imaging of the coronary arteries); previous coronary artery bypass surgery (CABG); previous percutaneous coronary intervention (PCI); previous myocardial infarction. (ACC) 187 C191383 COVID-19 Cardiovascular Complications HF || Heart failure C191396 Acute Cardiovascular Complications Related to COVID-19 Infection A clinical condition in which the function of the heart is inadequate to meet the metabolic needs of the body. C50577 Heart Failure Cardiac Failure Inability of the heart to pump blood at an adequate rate to meet tissue metabolic requirements. Clinical symptoms of heart failure include: unusual dyspnea on light exertion, recurrent dyspnea occurring in the supine position, fluid retention or rales, jugular venous distension, pulmonary edema on physical exam, or pulmonary edema on chest x-ray presumed to be cardiac dysfunction. 188 C191383 COVID-19 Cardiovascular Complications Blood pressure disorder || Hypotension C191396 Acute Cardiovascular Complications Related to COVID-19 Infection A condition in which the blood pressure is less than the below the fifth percentile or below 2 standard deviations of the mean for age and sex. C3128 Hypotension Low Blood Pressure || Vascular Hypotensive Disorder Blood pressure that is abnormally low. 189 C191383 COVID-19 Cardiovascular Complications Shock C191396 Acute Cardiovascular Complications Related to COVID-19 Infection C35016 Shock Circulatory Collapse A life-threatening condition that requires immediate medical intervention. It is characterized by reduced blood flow that may result in damage of multiple organs. Types of shock include cardiogenic, hemorrhagic, septic, anaphylactic, and traumatic shock. 190 C191383 COVID-19 Cardiovascular Complications Embolism C191396 Acute Cardiovascular Complications Related to COVID-19 Infection C26759 Embolism The blockage of a blood vessel lumen by air or solid material such as blood clot or other tissues (e.g., adipose tissue, cancer cells) that have migrated from another anatomic site. 191 C191383 COVID-19 Cardiovascular Complications Thrombosis C191396 Acute Cardiovascular Complications Related to COVID-19 Infection C26891 Thrombosis The formation of a blood clot in the lumen of a vessel or heart chamber; causes include coagulation disorders and vascular endothelial injury. 192 C191383 COVID-19 Cardiovascular Complications Vascular hypertensive disorder C191396 Acute Cardiovascular Complications Related to COVID-19 Infection C3117 Hypertension High Blood Pressure || Vascular Hypertensive Disorder Blood pressure that is abnormally high. 193 C191383 COVID-19 Cardiovascular Complications Other C191396 Acute Cardiovascular Complications Related to COVID-19 Infection A proper value is applicable but not known. C17649 Other Other or Miscellaneous Different than the one(s) previously specified or mentioned. 194 C191383 COVID-19 Cardiovascular Complications No C191396 Acute Cardiovascular Complications Related to COVID-19 Infection C49487 No The non-affirmative response to a question. 195 C191383 COVID-19 Cardiovascular Complications Unknown C191396 Acute Cardiovascular Complications Related to COVID-19 Infection A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 196 C191383 COVID-19 Cardiovascular Complications Cardiovascular adverse effects from vaccines to prevent COVID-19 C191396 Acute Cardiovascular Complications Related to COVID-19 Infection Cardiovascular adverse events associated with COVID-19 vaccinations C191446 Cardiovascular Adverse Effects from Vaccines to Prevent COVID-19 A cardiovascular adverse effect that is attributable to or associated with vaccines used to prevent COVID-19. 197 C191383 COVID-19 Cardiovascular Complications Myocarditis C191396 Acute Cardiovascular Complications Related to COVID-19 Infection C34831 Myocarditis Inflammation of the muscle tissue of the heart. 198 C191383 COVID-19 Cardiovascular Complications Thrombocytopenia C191396 Acute Cardiovascular Complications Related to COVID-19 Infection C3408 Thrombocytopenia A laboratory test result indicating that there is an abnormally small number of platelets in the circulating blood. 199 C191383 COVID-19 Cardiovascular Complications Thrombosis C191396 Acute Cardiovascular Complications Related to COVID-19 Infection C26891 Thrombosis The formation of a blood clot in the lumen of a vessel or heart chamber; causes include coagulation disorders and vascular endothelial injury. 200 C191383 COVID-19 Cardiovascular Complications Other C191396 Acute Cardiovascular Complications Related to COVID-19 Infection A proper value is applicable but not known. C17649 Other Other or Miscellaneous Different than the one(s) previously specified or mentioned. 201 C191383 COVID-19 Cardiovascular Complications No C191396 Acute Cardiovascular Complications Related to COVID-19 Infection C49487 No The non-affirmative response to a question. 202 C191383 COVID-19 Cardiovascular Complications Unknown C191396 Acute Cardiovascular Complications Related to COVID-19 Infection A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 203 C191383 COVID-19 Cardiovascular Complications PASC HF C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 New-onset HF with clinical syndrome of dyspnea, fatigue, fluid retention/peripheral edema that started during probable or confirmed acute COVID-19 and persisted beyond 4 wk after the initial diagnosis of COVID-19. Preexisting cardiovascular conditions, or those that did not develop until after COVID-19 had resolved, should not be listed here. C191555 New-onset Heart Failure Associated with Post-Acute Sequelae of SARS-CoV-2 Infection PASC Heart Failure || Post-Acute Sequelae of COVID-19 Heart Failure New onset of heart failure with a clinical syndrome of dyspnea, fatigue, fluid retention/peripheral edema that started during probable or confirmed acute COVID-19 and persisted beyond four weeks after the initial diagnosis of COVID-19. 204 C191383 COVID-19 Cardiovascular Complications Yes C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 205 C191383 COVID-19 Cardiovascular Complications No C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 C49487 No The non-affirmative response to a question. 206 C191383 COVID-19 Cardiovascular Complications Unknown C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 207 C191383 COVID-19 Cardiovascular Complications PASC ischemic cardiomyopathy C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 Reduced LV function with LVEF <50% in a patient with history of suspected or confirmed myocardial ischemia or ACS with acute COVID-19 that started during probable or confirmed acute COVID-19 and persisted beyond 4 wk after the initial diagnosis of COVID-19. Preexisting cardiovascular conditions, or those that did not develop until after COVID-19 had resolved, should not be listed here. C191478 Ischemic Cardiomyopathy Associated with Post-Acute Sequelae of SARS-CoV-2 Infection PASC Ischemic Cardiomyopathy || Post-Acute Sequelae of COVID-19 Ischemic Cardiomyopathy Reduced left ventricular function with less than 50% ejection fraction in a patient with history of suspected or confirmed myocardial ischemia or acute coronary syndrome (ACS) that started during probable or confirmed acute COVID-19 and persisted beyond four weeks after the initial diagnosis of COVID-19. 208 C191383 COVID-19 Cardiovascular Complications Yes C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 209 C191383 COVID-19 Cardiovascular Complications No C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 C49487 No The non-affirmative response to a question. 210 C191383 COVID-19 Cardiovascular Complications Unknown C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 211 C191383 COVID-19 Cardiovascular Complications PASC nonischemic cardiomyopathy C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 Reduced LV function with LVEF <50% without evidence of myocardial ischemia that started during probable or confirmed acute COVID-19 and persisted beyond 4 wk after the initial diagnosis of COVID-19. Preexisting cardiovascular conditions, or those that did not develop until after COVID-19 had resolved, should not be listed here. C191479 Non-Ischemic Cardiomyopathy Associated with Post-Acute Sequelae of SARS-CoV-2 Infection PASC Non-Ischemic Cardiomyopathy || Post-Acute Sequelae of COVID-19 Non-Ischemic Cardiomyopathy Reduced left ventricular function with less than 50% ejection fraction but without evidence of myocardial ischemia that started during probable or confirmed acute COVID-19 and persisted beyond four weeks after the initial diagnosis of COVID-19. 212 C191383 COVID-19 Cardiovascular Complications Yes C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 213 C191383 COVID-19 Cardiovascular Complications No C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 C49487 No The non-affirmative response to a question. 214 C191383 COVID-19 Cardiovascular Complications Unknown C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 215 C191383 COVID-19 Cardiovascular Complications PASC inappropriate sinus tachycardia C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 Inappropriate sinus tachycardia at rest with heart rate >100 bpm that cannot be explained by any identifiable cause, including anemia, hypoxia, hypotension, or fever that started during probable or confirmed acute COVID-19 and persisted beyond 4 wk after the initial diagnosis of COVID-19. Preexisting cardiovascular conditions, or those that did not develop until after COVID-19 had resolved, should not be listed here. C191565 Inappropriate Sinus Tachycardia Associated with Post-Acute Sequelae of SARS-CoV-2 Infection PASC Inappropriate Sinus Tachycardia || Post-Acute Sequelae of COVID-19 Inappropriate Sinus Tachycardia Inappropriate sinus tachycardia at rest with heart rate greater than 100 bpm that cannot be explained by any identifiable cause, including anemia, hypoxia, hypotension, or fever that started during probable or confirmed acute COVID-19 and persisted beyond four weeks after the initial diagnosis of COVID-19. 216 C191383 COVID-19 Cardiovascular Complications Yes C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 217 C191383 COVID-19 Cardiovascular Complications No C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 C49487 No The non-affirmative response to a question. 218 C191383 COVID-19 Cardiovascular Complications Unknown C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 219 C191383 COVID-19 Cardiovascular Complications PASC POTS C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 PASC POTS is a clinical syndrome that started during probable or confirmed acute COVID-19 and lasts greater than or equal to 3 mo. POTS is defined as 1) sustained heart rate increment greater than or equal to 30 bpm within 10 min of standing or head-up tilt (for individuals who are age 12-19 y, the required heart rate increment is greater than or equal to 40 bpm); 2) absence of orthostatic hypotension (i.e., no sustained systolic blood pressure drop of greater than or equal to 20 mm Hg); 3) frequent symptoms of orthostatic intolerance during standing, with rapid improvement upon return to a supine position. Symptoms may include lightheadedness, palpitations, tremulousness, generalized weakness, blurred vision, and fatigue; 4) duration of symptoms for at least 3 mo; and 5) absence of other conditions explaining sinus tachycardia such as anorexia nervosa, primary anxiety disorders, hyperventilation, anemia, fever, pain, infection, dehydration, hyperthyroidism, pheochromocytoma, use of cardioactive drugs (e.g., sympathomimetics, anticholinergics) or severe deconditioning caused by prolonged bed rest. C191603 Postural Orthostatic Tachycardia Syndrome Associated with Post-Acute Sequelae of SARS-CoV-2 Infection PASC POTS || PASC Postural Orthostatic Tachycardia Syndrome || Post-Acute Sequelae of COVID-19 Postural Orthostatic Tachycardia Syndrome Postural orthostatic tachycardia syndrome (POTS) that started during probable or confirmed acute COVID-19 and persisted at least three months after the initial diagnosis of COVID-19. 220 C191383 COVID-19 Cardiovascular Complications Yes C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 221 C191383 COVID-19 Cardiovascular Complications No C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 C49487 No The non-affirmative response to a question. 222 C191383 COVID-19 Cardiovascular Complications Unknown C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 223 C191383 COVID-19 Cardiovascular Complications PASC AF C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 AF in a patient without prior history of atrial tachyarrhythmias that started during probable or confirmed acute COVID-19 and persisted beyond 4 wk after the initial diagnosis of COVID-19. Preexisting cardiovascular conditions, or those that did not develop until after COVID-19 had resolved, should not be listed here. C191453 Atrial Fibrillation Associated with Post-Acute Sequelae of SARS-CoV-2 Infection PASC Atrial Fibrillation || Post-Acute Sequelae of COVID-19 Atrial Fibrillation Atrial fibrillation in a patient without prior history of atrial tachyarrhythmias that started during probable or confirmed acute COVID-19 and persisted beyond four weeks after the initial diagnosis of COVID-19. 224 C191383 COVID-19 Cardiovascular Complications Yes C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 225 C191383 COVID-19 Cardiovascular Complications No C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 C49487 No The non-affirmative response to a question. 226 C191383 COVID-19 Cardiovascular Complications Unknown C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 227 C191383 COVID-19 Cardiovascular Complications PASC atrial flutter C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 Atrial flutter in a patient without prior history of atrial tachyarrhythmias that started during probable or confirmed acute COVID-19 and persisted beyond 4 wk after the initial diagnosis of COVID-19. Preexisting cardiovascular conditions, or those that did not develop until after COVID-19 had resolved, should not be listed here. C191455 Atrial Flutter Associated with Post-Acute Sequelae of SARS-CoV-2 Infection PASC Atrial Flutter || Post-Acute Sequelae of COVID-19 Atrial Flutter Atrial flutter in a patient without prior history of atrial tachyarrhythmias that started during probable or confirmed acute COVID-19 and persisted beyond four weeks after the initial diagnosis of COVID-19. 228 C191383 COVID-19 Cardiovascular Complications Yes C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 229 C191383 COVID-19 Cardiovascular Complications No C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 C49487 No The non-affirmative response to a question. 230 C191383 COVID-19 Cardiovascular Complications Unknown C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 231 C191383 COVID-19 Cardiovascular Complications PASC supraventricular tachyarrhythmia other than AF or atrial flutter C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 Supraventricular tachycardia other than AF or atrial flutter in a patient without prior history of atrial tachyarrhythmias that started during probable or confirmed acute COVID-19 and persisted beyond 4 wk after the initial diagnosis of COVID-19. Preexisting cardiovascular conditions, or those that did not develop until after COVID-19 had resolved, should not be listed here. C191630 Supraventricular Tachyarrhythmia Other than Atrial Fibrillation or Atrial Flutter Associated with Post-Acute Sequelae of SARS-CoV-2 Infection PASC Supraventricular Tachyarrhythmia Other than Atrial Fibrillation or Atrial Flutter || Post-Acute Sequelae of COVID-19 Supraventricular Tachyarrhythmia Other than Atrial Fibrillation or Atrial Flutter Supraventricular tachycardia other than atrial fibrillation or atrial flutter in a patient without prior history of atrial tachyarrhythmias that started during probable or confirmed acute COVID-19 and persisted beyond four weeks after the initial diagnosis of COVID-19. 232 C191383 COVID-19 Cardiovascular Complications Yes C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 233 C191383 COVID-19 Cardiovascular Complications No C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 C49487 No The non-affirmative response to a question. 234 C191383 COVID-19 Cardiovascular Complications Unknown C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 235 C191383 COVID-19 Cardiovascular Complications PASC pericarditis C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 Pericarditis characterized by chest pain, electrocardiographic changes or pericardial effusion, that started during probable or confirmed acute COVID-19 and persisted beyond 4 wk after the initial diagnosis of COVID-19. Preexisting cardiovascular conditions, or those that did not develop until after COVID-19 had resolved, should not be listed here. C191595 Pericarditis Associated with Post-Acute Sequelae of SARS-CoV-2 Infection PASC Pericarditis || Post-Acute Sequelae of COVID-19 Pericarditis Pericarditis that started during probable or confirmed acute COVID-19 and persisted beyond four weeks after the initial diagnosis of COVID-19. 236 C191383 COVID-19 Cardiovascular Complications Yes C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 237 C191383 COVID-19 Cardiovascular Complications No C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 C49487 No The non-affirmative response to a question. 238 C191383 COVID-19 Cardiovascular Complications Unknown C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 239 C191383 COVID-19 Cardiovascular Complications PASC pericardial effusion C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 Pericardial effusion that started during probable or confirmed acute COVID-19 and persisted beyond 4 wk after the initial diagnosis of COVID-19. Preexisting cardiovascular conditions, or those that did not develop until after COVID-19 had resolved, should not be listed here. C191593 Pericardial Effusion Associated with Post-Acute Sequelae of SARS-CoV-2 Infection PASC Pericardial Effusion || Post-Acute Sequelae of COVID-19 Pericardial Effusion Pericardial effusion that started during probable or confirmed acute COVID-19 and persisted beyond four weeks after the initial diagnosis of COVID-19. 240 C191383 COVID-19 Cardiovascular Complications Yes C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 241 C191383 COVID-19 Cardiovascular Complications No C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 C49487 No The non-affirmative response to a question. 242 C191383 COVID-19 Cardiovascular Complications Unknown C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 243 C191383 COVID-19 Cardiovascular Complications PASC cardiac structural abnormalities C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 Cardiac structural changes or abnormalities characterized by myocardial systolic dysfunction or myocardial edema or fibrosis on noninvasive cardiac imaging that started during probable or confirmed acute COVID-19 and persisted beyond 4 wk after the initial diagnosis of COVID-19. Preexisting cardiovascular conditions, or those that did not develop until after COVID-19 had resolved, should not be listed here. C191625 Cardiac Structural Abnormalities Associated with Post-Acute Sequelae of SARS-CoV-2 Infection PASC Cardiac Structural Abnormalities || Post-Acute Sequelae of COVID-19 Cardiac Structural Abnormalities Cardiac structural changes or abnormalities characterized by myocardial systolic dysfunction or myocardial edema or fibrosis on non-invasive cardiac imaging that started during probable or confirmed acute COVID-19 and persisted beyond four weeks after the initial diagnosis of COVID-19. 244 C191383 COVID-19 Cardiovascular Complications Yes C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 245 C191383 COVID-19 Cardiovascular Complications No C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 C49487 No The non-affirmative response to a question. 246 C191383 COVID-19 Cardiovascular Complications Unknown C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 247 C191383 COVID-19 Cardiovascular Complications PASC deep venous thrombosis C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 Formation of greater than or equal to 1 blood clots or thrombi in large veins of the body, diagnosed with Doppler ultrasound, occurring most frequently in lower extremities or upper extremities that started during probable or confirmed acute COVID-19 and persisted beyond 4 wk after the initial diagnosis of COVID-19. Preexisting cardiovascular conditions, or those that did not develop until after COVID-19 had resolved, should not be listed here. C191540 Deep Venous Thrombosis Associated with Post-Acute Sequelae of SARS-CoV-2 Infection PASC DVT || PASC Deep Venous Thrombosis || Post-Acute Sequelae of COVID-19 Deep Venous Thrombosis Formation of multiple thrombi in the large veins of the body, diagnosed with Doppler ultrasound, occurring most frequently in lower extremities or upper extremities, that started during probable or confirmed acute COVID-19 and persisted beyond four weeks after the initial diagnosis of COVID-19. 248 C191383 COVID-19 Cardiovascular Complications Yes C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 249 C191383 COVID-19 Cardiovascular Complications No C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 C49487 No The non-affirmative response to a question. 250 C191383 COVID-19 Cardiovascular Complications Unknown C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 251 C191383 COVID-19 Cardiovascular Complications PASC pulmonary thromboembolic disease C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 Intravascular migration of a venous thrombus or embolus to the pulmonary arterial circulation, microvascular thrombosis in the pulmonary capillaries, or pulmonary artery thrombus in situ diagnosed by a positive pulmonary angiogram, an unequivocally positive helical CT scan, a high-probability ventilation-perfusion scan, or autopsy that started during probable or confirmed acute COVID-19 and persisted beyond 4 wk after the initial diagnosis of COVID-19. Preexisting cardiovascular conditions, or those that did not develop until after COVID-19 had resolved, should not be listed here. C191611 Pulmonary Thromboembolic Disease Associated with Post-Acute Sequelae of SARS-CoV-2 Infection PASC Pulmonary Thromboembolic Disease || Post-Acute Sequelae of COVID-19 Pulmonary Thromboembolic Disease Intravascular migration of a venous embolus to the pulmonary arterial circulation, microvascular thrombosis in the pulmonary capillaries, or pulmonary artery thrombus in situ diagnosed by a positive pulmonary angiogram, an unequivocally positive helical CT scan, a high-probability ventilation-perfusion scan, or autopsy that started during probable or confirmed acute COVID-19 and persisted beyond four weeks after the initial diagnosis of COVID-19. 252 C191383 COVID-19 Cardiovascular Complications Yes C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 253 C191383 COVID-19 Cardiovascular Complications No C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 C49487 No The non-affirmative response to a question. 254 C191383 COVID-19 Cardiovascular Complications Unknown C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 255 C191383 COVID-19 Cardiovascular Complications PASC neurovascular disorder C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 Disorder of the nervous system related to a vascular etiology that started during probable or confirmed acute COVID-19 and persisted beyond 4 wk after the initial diagnosis of COVID-19. Preexisting cardiovascular conditions, or those that did not develop until after COVID-19 had resolved, should not be listed here. C191581 Neurovascular Disorder Associated with Post-Acute Sequelae of SARS-CoV-2 Infection PASC Neurovascular Disorder || Post-Acute Sequelae of COVID-19 Neurovascular Disorder A disorder of the nervous system related to a vascular etiology that started during probable or confirmed acute COVID-19 and persisted beyond four weeks after the initial diagnosis of COVID-19. 256 C191383 COVID-19 Cardiovascular Complications Acute ischemic stroke || Ischemic stroke C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 Acute onset of neurological deficits resulting from a loss of blood supply to brain tissue in an area of arterial distribution. C95802 Ischemic Stroke Ischemic Cerebrovascular Accident An acute episode of focal cerebral, spinal, or retinal dysfunction caused by infarction of brain tissue. 257 C191383 COVID-19 Cardiovascular Complications Hemorrhagic stroke C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 Brain tissue necrosis due to an intracerebral bleed C95803 Hemorrhagic Stroke Hemorrhagic Cerebrovascular Accident An acute episode of focal or global cerebral or spinal dysfunction caused by intraparenchymal, intraventricular, or subarachnoid hemorrhage. 258 C191383 COVID-19 Cardiovascular Complications Cerebral venous thrombosis C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 C132727 Cerebral Vein Thrombosis The formation of a blood clot in a cerebral vein. 259 C191383 COVID-19 Cardiovascular Complications Myalgic encephalomyelitis/chronic fatigue syndrome C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 C3037 Chronic Fatigue Syndrome Myalgic Encephalomyelitis A syndrome of unknown etiology. Chronic fatigue syndrome (CFS) is a clinical diagnosis characterized by an unexplained persistent or relapsing chronic fatigue that is of at least six months' duration, is not the result of ongoing exertion, is not substantially alleviated by rest, and results in substantial reduction of previous levels of occupational, educational, social, or personal activities. Common concurrent symptoms of at least six months duration include impairment of memory or concentration, diffuse pain, sore throat, tender lymph nodes, headaches of a new type, pattern, or severity, and nonrestorative sleep. The etiology of CFS may be viral or immunologic. Neurasthenia and fibromyalgia may represent related disorders. Also known as myalgic encephalomyelitis. 260 C191383 COVID-19 Cardiovascular Complications Other C191403 Postacute Cardiovascular Sequelae of SARS-CoV-2 Infection or Long-Term Cardiovascular Complications of COVID-19 A proper value is applicable but not known. C17649 Other Other or Miscellaneous Different than the one(s) previously specified or mentioned. 261 C191383 COVID-19 Cardiovascular Complications Death due to acute MI C191397 Cardiovascular Mortality During Acute COVID-19 Infection Death by any cardiovascular mechanism (e.g., arrhythmia, sudden death, HF, stroke, pulmonary embolus, peripheral arterial disease) less than or equal to 30 d after a MI, related to the immediate consequences of the MI, such as progressive HF or recalcitrant arrhythmia in a patient with probable or confirmed acute COVID-19. There may be assessable mechanisms of cardiovascular death during this time period, but for simplicity, if the cardiovascular death occurs less than or equal to 30 d of the MI, it will be considered a death due to MI. C191480 Death due to Acute Myocardial Infarction Related to COVID-19 Death by any cardiovascular mechanism (e.g., arrhythmia, sudden death, heart failure (HF), stroke, pulmonary embolus, peripheral arterial disease) less than or equal to 30 days after a myocardial infarction (MI), related to the immediate consequences of the MI, such as progressive HF or recalcitrant arrhythmia in a patient with probable or confirmed acute COVID-19. 262 C191383 COVID-19 Cardiovascular Complications Yes C191397 Cardiovascular Mortality During Acute COVID-19 Infection ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 263 C191383 COVID-19 Cardiovascular Complications No C191397 Cardiovascular Mortality During Acute COVID-19 Infection C49487 No The non-affirmative response to a question. 264 C191383 COVID-19 Cardiovascular Complications Unknown C191397 Cardiovascular Mortality During Acute COVID-19 Infection A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 265 C191383 COVID-19 Cardiovascular Complications Sudden cardiac death C191397 Cardiovascular Mortality During Acute COVID-19 Infection Death that occurs unexpectedly and suddenly without ROSC in a patient with probable or confirmed acute COVID-19 and not within 30 d of an acute MI. Sudden cardiac death includes the following scenarios: a. Death witnessed and occurring without new or worsening symptoms b. Death witnessed within 60 min of the onset of new or worsening cardiac symptoms, unless the symptoms suggest acute MI c. Death witnessed and attributed to an identified arrhythmia (e.g., captured on an ECG recording, witnessed on a monitor, with asystole, pulseless electrical activity, ventricular tachycardia, or ventricular fibrillation, or unwitnessed but found on implantable cardioverter-defibrillator review) d. Unwitnessed death in a subject seen alive and clinically stable less than or equal to 24 h prior to being found dead without any evidence supporting a specific noncardiovascular cause of death (information regarding the patient's clinical status preceding death should be provided, if available) C191626 Sudden Cardiac Death Related to COVID-19 SCD Related to COVID-19 Sudden cardiac death in a patient with probable or confirmed acute COVID-19. 266 C191383 COVID-19 Cardiovascular Complications Yes C191397 Cardiovascular Mortality During Acute COVID-19 Infection ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 267 C191383 COVID-19 Cardiovascular Complications No C191397 Cardiovascular Mortality During Acute COVID-19 Infection C49487 No The non-affirmative response to a question. 268 C191383 COVID-19 Cardiovascular Complications Unknown C191397 Cardiovascular Mortality During Acute COVID-19 Infection A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 269 C191383 COVID-19 Cardiovascular Complications Death due to HF C191397 Cardiovascular Mortality During Acute COVID-19 Infection Death in association with clinically worsening symptoms or signs of HF regardless of HF etiology in a patient with probable or confirmed acute COVID-19. Deaths due to HF with COVID-19 can have various etiologies, including myocarditis, myocardial injury, cardiogenic shock, cardiomyopathy, MI, ischemic or nonischemic cardiomyopathy. C191537 Death due to Heart Failure Related to COVID-19 Death in association with clinically worsening symptoms or signs of heart failure regardless of etiology in a patient with probable or confirmed acute COVID-19. 270 C191383 COVID-19 Cardiovascular Complications Yes C191397 Cardiovascular Mortality During Acute COVID-19 Infection ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 271 C191383 COVID-19 Cardiovascular Complications No C191397 Cardiovascular Mortality During Acute COVID-19 Infection C49487 No The non-affirmative response to a question. 272 C191383 COVID-19 Cardiovascular Complications Unknown C191397 Cardiovascular Mortality During Acute COVID-19 Infection A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 273 C191383 COVID-19 Cardiovascular Complications Death due to stroke C191397 Cardiovascular Mortality During Acute COVID-19 Infection Death after a stroke that is either a direct consequence of the stroke or a complication of the stroke in a patient with probable or confirmed acute COVID-19. Acute stroke should be verified to the extent possible by the diagnostic criteria outlined for stroke. C191539 Death due to Stroke Related to COVID-19 Death following a stroke that is either a direct consequence of the stroke or a complication of the stroke in a patient with probable or confirmed acute COVID-19. 274 C191383 COVID-19 Cardiovascular Complications Yes C191397 Cardiovascular Mortality During Acute COVID-19 Infection ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 275 C191383 COVID-19 Cardiovascular Complications No C191397 Cardiovascular Mortality During Acute COVID-19 Infection C49487 No The non-affirmative response to a question. 276 C191383 COVID-19 Cardiovascular Complications Unknown C191397 Cardiovascular Mortality During Acute COVID-19 Infection A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 277 C191383 COVID-19 Cardiovascular Complications Death due to cardiovascular procedure C191397 Cardiovascular Mortality During Acute COVID-19 Infection Death caused by the immediate complications of a cardiovascular procedure in a patient with probable or confirmed acute COVID-19 C191464 Death due to Cardiovascular Procedure Related to COVID-19 Death caused by complications of a cardiovascular procedure in a patient with probable or confirmed acute COVID-19. 278 C191383 COVID-19 Cardiovascular Complications Yes C191397 Cardiovascular Mortality During Acute COVID-19 Infection ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 279 C191383 COVID-19 Cardiovascular Complications No C191397 Cardiovascular Mortality During Acute COVID-19 Infection C49487 No The non-affirmative response to a question. 280 C191383 COVID-19 Cardiovascular Complications Unknown C191397 Cardiovascular Mortality During Acute COVID-19 Infection A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 281 C191383 COVID-19 Cardiovascular Complications Death due to cardiovascular hemorrhage C191397 Cardiovascular Mortality During Acute COVID-19 Infection Death related to hemorrhage such as a nonstroke intracranial hemorrhage (e.g., subdural hematoma), nonprocedural or nontraumatic vascular rupture (e.g., aortic aneurysm), or hemorrhage causing cardiac tamponade in a patient with probable or confirmed acute COVID-19 C191463 Death due to Cardiovascular Hemorrhage Related to COVID-19 Death related to hemorrhage such as a non-stroke intracranial hemorrhage, non-procedural or non-traumatic vascular rupture, or hemorrhage causing cardiac tamponade in a patient with probable or confirmed acute COVID-19. 282 C191383 COVID-19 Cardiovascular Complications Yes C191397 Cardiovascular Mortality During Acute COVID-19 Infection ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 283 C191383 COVID-19 Cardiovascular Complications No C191397 Cardiovascular Mortality During Acute COVID-19 Infection C49487 No The non-affirmative response to a question. 284 C191383 COVID-19 Cardiovascular Complications Unknown C191397 Cardiovascular Mortality During Acute COVID-19 Infection A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 285 C191383 COVID-19 Cardiovascular Complications Death due to pulmonary embolus C191397 Cardiovascular Mortality During Acute COVID-19 Infection Death caused by pulmonary embolus in a patient with probable or confirmed acute COVID-19 C191538 Death due to Pulmonary Embolus Related to COVID-19 Death as a consequence of pulmonary embolism in a patient with probable or confirmed acute COVID-19. 286 C191383 COVID-19 Cardiovascular Complications Yes C191397 Cardiovascular Mortality During Acute COVID-19 Infection ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 287 C191383 COVID-19 Cardiovascular Complications No C191397 Cardiovascular Mortality During Acute COVID-19 Infection C49487 No The non-affirmative response to a question. 288 C191383 COVID-19 Cardiovascular Complications Unknown C191397 Cardiovascular Mortality During Acute COVID-19 Infection A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 289 C191383 COVID-19 Cardiovascular Complications Death due to other cardiovascular causes C191397 Cardiovascular Mortality During Acute COVID-19 Infection Cardiovascular death not included in the above categories but with a specific, known cause (e.g., peripheral arterial disease) C191465 Death due to Other Cardiovascular Cause Related to COVID-19 Death from a cardiovascular cause not otherwise noted but with a specific, known cause in a patient with probable or confirmed acute COVID-19. 290 C191383 COVID-19 Cardiovascular Complications Yes C191397 Cardiovascular Mortality During Acute COVID-19 Infection ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 291 C191383 COVID-19 Cardiovascular Complications No C191397 Cardiovascular Mortality During Acute COVID-19 Infection C49487 No The non-affirmative response to a question. 292 C191383 COVID-19 Cardiovascular Complications Unknown C191397 Cardiovascular Mortality During Acute COVID-19 Infection A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 293 C191384 COVID-19 Noncardiovascular Complications ARDS ARDS meeting standard clinical criteria in a patient with probable or confirmed COVID-19 and felt to be secondary to COVID-19 C171551 COVID-19-Associated Acute Respiratory Distress Syndrome SARS-CoV-2-Associated Acute Respiratory Distress Syndrome Acute respiratory distress syndrome caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). 294 C191384 COVID-19 Noncardiovascular Complications Yes ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 295 C191384 COVID-19 Noncardiovascular Complications No C49487 No The non-affirmative response to a question. 296 C191384 COVID-19 Noncardiovascular Complications Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 297 C191384 COVID-19 Noncardiovascular Complications Pneumonia Clinical pneumonia or asymptomatic pulmonary infiltrates in a patient with probable or confirmed COVID-19 and felt to be secondary to COVID-19 C171550 COVID-19-Associated Pneumonia SARS-CoV-2 -Associated Pneumonia Pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is characterized by the presence of ground glass opacities on CT scan images. 298 C191384 COVID-19 Noncardiovascular Complications Yes ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 299 C191384 COVID-19 Noncardiovascular Complications No C49487 No The non-affirmative response to a question. 300 C191384 COVID-19 Noncardiovascular Complications Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 301 C191384 COVID-19 Noncardiovascular Complications Distributive shock Distributive shock (e.g., due to sepsis or SIRS), defined as an inadequate supply of oxygen at the tissue level to meet metabolic needs in a vasodilated state in a patient with probable or confirmed COVID-19 C191620 Distributive Shock Related to COVID-19 Vasodilatory Shock Related to COVID-19 Systemic vasodilation leading to decreased blood flow to organs in a patient with probable or confirmed acute COVID-19. 302 C191384 COVID-19 Noncardiovascular Complications Yes ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 303 C191384 COVID-19 Noncardiovascular Complications No C49487 No The non-affirmative response to a question. 304 C191384 COVID-19 Noncardiovascular Complications Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 305 C191384 COVID-19 Noncardiovascular Complications Acute kidney injury with renal replacement therapy Abrupt reduction in kidney function in a patient with probable or confirmed COVID-19, measured by urine output and renal biomarkers requiring any renal replacement therapy C191516 Acute Kidney Injury with Renal Replacement Therapy Related to COVID-19 Abrupt reduction in kidney function as measured by urine output and renal biomarkers requiring any renal replacement therapy in a patient with probable or confirmed acute COVID-19. 306 C191384 COVID-19 Noncardiovascular Complications Yes ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 307 C191384 COVID-19 Noncardiovascular Complications No C49487 No The non-affirmative response to a question. 308 C191384 COVID-19 Noncardiovascular Complications Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 309 C191384 COVID-19 Noncardiovascular Complications Acute kidney injury without renal replacement therapy Abrupt reduction in kidney function in a patient with probable or confirmed COVID-19, measured by urine output and renal biomarkers not requiring temporary or permanent renal replacement therapy C191517 Acute Kidney Injury without Renal Replacement Therapy Related to COVID-19 Abrupt reduction in kidney function as measured by urine output and renal biomarkers but not requiring any renal replacement therapy in a patient with probable or confirmed acute COVID-19. 310 C191384 COVID-19 Noncardiovascular Complications Yes ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 311 C191384 COVID-19 Noncardiovascular Complications No C49487 No The non-affirmative response to a question. 312 C191384 COVID-19 Noncardiovascular Complications Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 313 C191384 COVID-19 Noncardiovascular Complications Acute liver injury with fulminant failure Acute liver injury manifested by abnormalities in liver enzymes in a patient with probable or confirmed COVID-19. A minority of patients experience severe liver injury that can result in hepatic failure, defined as rapid loss of liver function during acute COVID-19, which is associated with coagulopathy or encephalopathy, and often multiorgan failure. C191518 Acute Liver Injury with Fulminant Failure Related to COVID-19 Acute liver injury manifested by rapid loss of liver function associated with abnormal liver enzyme levels, coagulopathy or encephalopathy, and often multiorgan failure in a patient with probable or confirmed acute COVID-19. 314 C191384 COVID-19 Noncardiovascular Complications Yes ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 315 C191384 COVID-19 Noncardiovascular Complications No C49487 No The non-affirmative response to a question. 316 C191384 COVID-19 Noncardiovascular Complications Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 317 C191384 COVID-19 Noncardiovascular Complications Acute liver injury without fulminant failure Acute liver injury in a patient with probable or confirmed COVID-19, defined as abnormal liver chemistries >2' ULN in the absence of signs of hepatic failure (e.g., no coagulopathy or encephalopathy), is usually mild, transient, and does not require intervention. C191519 Acute Liver Injury without Fulminant Failure Related to COVID-19 Acute liver injury associated with abnormal liver chemistries (greater than two times the upper limit of normal) in the absence of signs of hepatic failure (e.g., no coagulopathy or encephalopathy) in a patient with probable or confirmed acute COVID-19. This is usually mild, transient, and does not require intervention. 318 C191384 COVID-19 Noncardiovascular Complications Yes ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 319 C191384 COVID-19 Noncardiovascular Complications No C49487 No The non-affirmative response to a question. 320 C191384 COVID-19 Noncardiovascular Complications Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 321 C191384 COVID-19 Noncardiovascular Complications Disseminated intravascular coagulation Abnormalities in coagulation and fibrinolysis, resulting in a condition in which blood clots form throughout the body, thereby causing clotting in small blood vessels and increasing risk for hemorrhage, in a patient with probable or confirmed COVID-19 C191542 Disseminated Intravascular Coagulation Related to COVID-19 DIC Related to COVID-19 Disseminated intravascular coagulation in a patient with probable or confirmed acute COVID-19. 322 C191384 COVID-19 Noncardiovascular Complications Yes ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 323 C191384 COVID-19 Noncardiovascular Complications No C49487 No The non-affirmative response to a question. 324 C191384 COVID-19 Noncardiovascular Complications Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 325 C191384 COVID-19 Noncardiovascular Complications Rhabdomyolysis Destruction or degeneration of muscle tissue accompanied by the release of breakdown products from muscle cells into the bloodstream (e.g., creatine kinase, aldolase) that may lead to acute kidney injury in a patient with probable or confirmed COVID-19 C191617 Rhabdomyolysis Related to COVID-19 Rhabdomyolysis in a patient with probable or confirmed acute COVID-19. 326 C191384 COVID-19 Noncardiovascular Complications Yes ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 327 C191384 COVID-19 Noncardiovascular Complications No C49487 No The non-affirmative response to a question. 328 C191384 COVID-19 Noncardiovascular Complications Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 329 C191384 COVID-19 Noncardiovascular Complications Seizures Convulsions, sensory, cognitive disturbances, or loss of consciousness resulting from abnormal electrical discharges in the brain in a patient with probable or confirmed COVID-19 C191619 Seizure Related to COVID-19 Convulsion Related to COVID-19 Seizure in a patient with probable or confirmed acute COVID-19. 330 C191384 COVID-19 Noncardiovascular Complications Yes ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 331 C191384 COVID-19 Noncardiovascular Complications No C49487 No The non-affirmative response to a question. 332 C191384 COVID-19 Noncardiovascular Complications Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 333 C191384 COVID-19 Noncardiovascular Complications Encephalopathy A functional or structural disorder of the brain C191549 Encephalopathy Related to COVID-19 Encephalopathy in a patient with probable or confirmed acute COVID-19. 334 C191384 COVID-19 Noncardiovascular Complications Yes ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 335 C191384 COVID-19 Noncardiovascular Complications No C49487 No The non-affirmative response to a question. 336 C191384 COVID-19 Noncardiovascular Complications Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 337 C191384 COVID-19 Noncardiovascular Complications Loss of smell (anosmia) Loss or impairment of olfactory function during COVID-19 C171558 COVID-19-Associated Anosmia SARS-CoV-2-Associated Anosmia Anosmia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). 338 C191384 COVID-19 Noncardiovascular Complications Yes ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 339 C191384 COVID-19 Noncardiovascular Complications No C49487 No The non-affirmative response to a question. 340 C191384 COVID-19 Noncardiovascular Complications Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 341 C191384 COVID-19 Noncardiovascular Complications Loss of taste (ageusia) Loss or impairment of gustatory function during COVID-19 C173629 COVID-19-Associated Ageusia COVID-19 Associated Loss of Taste Ageusia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). 342 C191384 COVID-19 Noncardiovascular Complications Yes ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 343 C191384 COVID-19 Noncardiovascular Complications No C49487 No The non-affirmative response to a question. 344 C191384 COVID-19 Noncardiovascular Complications Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 345 C191384 COVID-19 Noncardiovascular Complications Pregnancy loss or other adverse pregnancy outcome Pregnancy loss or other adverse pregnancy outcome (hypertensive disorders of pregnancy, preterm delivery, small for gestational age birth, gestational diabetes) in a patient with probable or confirmed COVID-19 C191604 Pregnancy Complication Related to COVID-19 A pregnancy complication in a patient with probable or confirmed acute COVID-19. 346 C191384 COVID-19 Noncardiovascular Complications Yes ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 347 C191384 COVID-19 Noncardiovascular Complications No C49487 No The non-affirmative response to a question. 348 C191384 COVID-19 Noncardiovascular Complications Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 349 C191384 COVID-19 Noncardiovascular Complications Syncope Abrupt, transient, complete loss of consciousness, associated with the inability to maintain postural tone and rapid, spontaneous recovery in a patient with probable or confirmed COVID-19 C191629 Syncope Related to COVID-19 Syncope in a patient with probable or confirmed acute COVID-19. 350 C191384 COVID-19 Noncardiovascular Complications Yes ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 351 C191384 COVID-19 Noncardiovascular Complications No C49487 No The non-affirmative response to a question. 352 C191384 COVID-19 Noncardiovascular Complications Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 353 C191384 COVID-19 Noncardiovascular Complications Presyncope The symptoms before syncope. These symptoms could include extreme lightheadedness; visual sensations, such as "tunnel vision" or "graying out"; and variable degrees of altered consciousness without complete loss of consciousness. Presyncope could progress to syncope, or it could abort without syncope. C191606 Presyncope Related to COVID-19 Presyncope in a patient with probable or confirmed acute COVID-19. 354 C191384 COVID-19 Noncardiovascular Complications Yes ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 355 C191384 COVID-19 Noncardiovascular Complications No C49487 No The non-affirmative response to a question. 356 C191384 COVID-19 Noncardiovascular Complications Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 357 C191384 COVID-19 Noncardiovascular Complications Cerebral vein thrombosis The formation of a blood clot in a cerebral vein C191485 Cerebral Venous Thrombosis Related to COVID-19 358 C191384 COVID-19 Noncardiovascular Complications Yes ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 359 C191384 COVID-19 Noncardiovascular Complications No C49487 No The non-affirmative response to a question. 360 C191384 COVID-19 Noncardiovascular Complications Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 361 C191384 COVID-19 Noncardiovascular Complications Other noncardiovascular complication Other noncardiovascular symptom(s) in a patient with probable or confirmed COVID-19 such as peripheral neuropathy, gastrointestinal distress or diarrhea, de novo or acute worsening of chronic hyperglycemia, ocular symptoms, and livedo reticularis, which may be related to direct viral tissue damage or systemic inflammation and immunopathological damage C191511 Non-Cardiovascular Complication Related to COVID-19 A complication in a patient with probable or confirmed acute COVID-19 that is not associated with a cardiovascular cause. 362 C191384 COVID-19 Noncardiovascular Complications Yes ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 363 C191384 COVID-19 Noncardiovascular Complications No C49487 No The non-affirmative response to a question. 364 C191384 COVID-19 Noncardiovascular Complications Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 365 C191385 Symptoms and Signs Cough || Coughing C191398 Current Symptoms and Signs: Clinical Symptoms A sudden, often repetitive, spasmodic contraction of the thoracic cavity, resulting in violent release of air from the lungs, and usually accompanied by a distinctive sound C37935 Cough A sudden, often repetitive, spasmodic contraction of the thoracic cavity, resulting in violent release of air from the lungs, and usually accompanied by a distinctive sound. 366 C191385 Symptoms and Signs Yes C191398 Current Symptoms and Signs: Clinical Symptoms ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 367 C191385 Symptoms and Signs No C191398 Current Symptoms and Signs: Clinical Symptoms C49487 No The non-affirmative response to a question. 368 C191385 Symptoms and Signs Unknown C191398 Current Symptoms and Signs: Clinical Symptoms A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 369 C191385 Symptoms and Signs Dyspnea || Presence and severity of dyspnea C191398 Current Symptoms and Signs: Clinical Symptoms An uncomfortable sensation of difficulty breathing. It may present as an acute or chronic sign of an underlying respiratory or heart disorder. C2998 Dyspnea Shortness of Breath An uncomfortable sensation of difficulty breathing. It may present as an acute or chronic sign of an underlying respiratory or heart disorder. 370 C191385 Symptoms and Signs No limitation of physical activity by dyspnea C191398 Current Symptoms and Signs: Clinical Symptoms C191548 Dyspnea with No Physical Activity Limitation Dyspnea that does not interfere with their physical activity. 371 C191385 Symptoms and Signs Dyspnea with moderate physical activity C191398 Current Symptoms and Signs: Clinical Symptoms C191547 Dyspnea with Moderate Physical Activity Dyspnea experienced during moderate exertion. 372 C191385 Symptoms and Signs Dyspnea with mild physical activity C191398 Current Symptoms and Signs: Clinical Symptoms C191546 Dyspnea with Mild Physical Activity Dyspnea experienced during minimal exertion. 373 C191385 Symptoms and Signs Dyspnea at rest C191398 Current Symptoms and Signs: Clinical Symptoms C191545 Dyspnea at Rest Dyspnea experienced while at rest. 374 C191385 Symptoms and Signs Orthopnea C191398 Current Symptoms and Signs: Clinical Symptoms Uncomfortable awareness of breathing while in a supine position, improved by sitting upright or standing C191448 Orthopnea Shortness of breath while lying down and which is relived by sitting or standing. 375 C191385 Symptoms and Signs Yes C191398 Current Symptoms and Signs: Clinical Symptoms ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 376 C191385 Symptoms and Signs No C191398 Current Symptoms and Signs: Clinical Symptoms C49487 No The non-affirmative response to a question. 377 C191385 Symptoms and Signs Unknown C191398 Current Symptoms and Signs: Clinical Symptoms A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 378 C191385 Symptoms and Signs Paroxysmal nocturnal dyspnea C191398 Current Symptoms and Signs: Clinical Symptoms Sudden awakening from sleep with uncomfortable awareness of breathing, relieved by sitting upright or standing. A reported duration >5 min is considered positive. C34561 Paroxysmal Nocturnal Dyspnea Cardiac Asthma Sudden onset of shortness of breath that causes one to awaken coughing or wheezing; it may be associated with congestive heart failure or chronic obstructive pulmonary disease. 379 C191385 Symptoms and Signs Yes C191398 Current Symptoms and Signs: Clinical Symptoms ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 380 C191385 Symptoms and Signs No C191398 Current Symptoms and Signs: Clinical Symptoms C49487 No The non-affirmative response to a question. 381 C191385 Symptoms and Signs Unknown C191398 Current Symptoms and Signs: Clinical Symptoms A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 382 C191385 Symptoms and Signs Fatigue || Fatigue (lassitude) C191398 Current Symptoms and Signs: Clinical Symptoms A state of exhaustion usually caused by various etiologies such as a period of mental or bodily activity, sleep deprivation, medications, chronic disease, or other factors. C3036 Fatigue Lack of Energy Overall tiredness and lack of energy. 383 C191385 Symptoms and Signs Yes C191398 Current Symptoms and Signs: Clinical Symptoms ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 384 C191385 Symptoms and Signs No C191398 Current Symptoms and Signs: Clinical Symptoms C49487 No The non-affirmative response to a question. 385 C191385 Symptoms and Signs Unknown C191398 Current Symptoms and Signs: Clinical Symptoms A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 386 C191385 Symptoms and Signs Syncope C191398 Current Symptoms and Signs: Clinical Symptoms Abrupt, transient, complete loss of consciousness, associated with inability to maintain postural tone, with rapid and spontaneous recovery C35053 Syncope A spontaneous loss of consciousness caused by insufficient blood supply to the brain. 387 C191385 Symptoms and Signs Yes C191398 Current Symptoms and Signs: Clinical Symptoms ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 388 C191385 Symptoms and Signs No C191398 Current Symptoms and Signs: Clinical Symptoms C49487 No The non-affirmative response to a question. 389 C191385 Symptoms and Signs Unknown C191398 Current Symptoms and Signs: Clinical Symptoms A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 390 C191385 Symptoms and Signs Presyncope C191398 Current Symptoms and Signs: Clinical Symptoms The symptoms before syncope. These symptoms could include extreme lightheadedness; visual sensations, such as "tunnel vision" or "graying out"; and variable degrees of altered consciousness without complete loss of consciousness. Presyncope could progress to syncope, or it could abort without syncope. C80100 Presyncope An episode of lightheadedness and dizziness which may precede an episode of syncope. 391 C191385 Symptoms and Signs Yes C191398 Current Symptoms and Signs: Clinical Symptoms ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 392 C191385 Symptoms and Signs No C191398 Current Symptoms and Signs: Clinical Symptoms C49487 No The non-affirmative response to a question. 393 C191385 Symptoms and Signs Unknown C191398 Current Symptoms and Signs: Clinical Symptoms A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 394 C191385 Symptoms and Signs Acute pulmonary edema C191398 Current Symptoms and Signs: Clinical Symptoms Acute onset or rapid progression of pulmonary edema causing significant hypoxemia or need for supplemental oxygen C191610 Acute Pulmonary Edema Rapid or severe onset or rapid progression of pulmonary edema causing significant hypoxemia or the need for supplemental oxygen. 395 C191385 Symptoms and Signs Yes C191398 Current Symptoms and Signs: Clinical Symptoms ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 396 C191385 Symptoms and Signs No C191398 Current Symptoms and Signs: Clinical Symptoms C49487 No The non-affirmative response to a question. 397 C191385 Symptoms and Signs Unknown C191398 Current Symptoms and Signs: Clinical Symptoms A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 398 C191385 Symptoms and Signs Fever C191398 Current Symptoms and Signs: Clinical Symptoms Temperature greater than or equal to 100.4 degrees F (38.0 degrees C) C3038 Fever Elevation of body temperature above normal due to inflammatory or immune responses. 399 C191385 Symptoms and Signs Yes C191398 Current Symptoms and Signs: Clinical Symptoms ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 400 C191385 Symptoms and Signs No C191398 Current Symptoms and Signs: Clinical Symptoms C49487 No The non-affirmative response to a question. 401 C191385 Symptoms and Signs Unknown C191398 Current Symptoms and Signs: Clinical Symptoms A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 402 C191385 Symptoms and Signs Loss of smell (anosmia) C191398 Current Symptoms and Signs: Clinical Symptoms Loss or impairment of olfactory function during COVID-19 C171558 COVID-19-Associated Anosmia SARS-CoV-2-Associated Anosmia Anosmia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). 403 C191385 Symptoms and Signs Yes C191398 Current Symptoms and Signs: Clinical Symptoms ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 404 C191385 Symptoms and Signs No C191398 Current Symptoms and Signs: Clinical Symptoms C49487 No The non-affirmative response to a question. 405 C191385 Symptoms and Signs Unknown C191398 Current Symptoms and Signs: Clinical Symptoms A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 406 C191385 Symptoms and Signs Loss of taste (ageusia) C191398 Current Symptoms and Signs: Clinical Symptoms Loss or impairment of gustatory function during COVID-19 C173629 COVID-19-Associated Ageusia COVID-19 Associated Loss of Taste Ageusia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). 407 C191385 Symptoms and Signs Yes C191398 Current Symptoms and Signs: Clinical Symptoms ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 408 C191385 Symptoms and Signs No C191398 Current Symptoms and Signs: Clinical Symptoms C49487 No The non-affirmative response to a question. 409 C191385 Symptoms and Signs Unknown C191398 Current Symptoms and Signs: Clinical Symptoms A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 410 C191385 Symptoms and Signs Diarrhea C191398 Current Symptoms and Signs: Clinical Symptoms Passage of greater than or equal to 3 loose or liquid stools per day (or more frequent passage than is normal for the individual) C2987 Diarrhea Watery bowel movements. 411 C191385 Symptoms and Signs Yes C191398 Current Symptoms and Signs: Clinical Symptoms ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 412 C191385 Symptoms and Signs No C191398 Current Symptoms and Signs: Clinical Symptoms C49487 No The non-affirmative response to a question. 413 C191385 Symptoms and Signs Unknown C191398 Current Symptoms and Signs: Clinical Symptoms A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 414 C191385 Symptoms and Signs Nausea C191398 Current Symptoms and Signs: Clinical Symptoms The inclination to vomit C3258 Nausea Upper abdominal discomfort associated with an urge to vomit. 415 C191385 Symptoms and Signs Yes C191398 Current Symptoms and Signs: Clinical Symptoms ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 416 C191385 Symptoms and Signs No C191398 Current Symptoms and Signs: Clinical Symptoms C49487 No The non-affirmative response to a question. 417 C191385 Symptoms and Signs Unknown C191398 Current Symptoms and Signs: Clinical Symptoms A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 418 C191385 Symptoms and Signs Vomiting C191398 Current Symptoms and Signs: Clinical Symptoms Vomiting C3442 Vomiting Emesis Forceful ejection of the contents of the stomach through the mouth. 419 C191385 Symptoms and Signs Yes C191398 Current Symptoms and Signs: Clinical Symptoms ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 420 C191385 Symptoms and Signs No C191398 Current Symptoms and Signs: Clinical Symptoms C49487 No The non-affirmative response to a question. 421 C191385 Symptoms and Signs Unknown C191398 Current Symptoms and Signs: Clinical Symptoms A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 422 C191385 Symptoms and Signs Seizure || Seizures C191398 Current Symptoms and Signs: Clinical Symptoms Convulsions, sensory, cognitive disturbances, or loss of consciousness resulting from abnormal electrical discharges in the brain in a patient with probable or confirmed COVID-19 C2962 Seizure Convulsion Sudden, involuntary skeletal muscular contractions of cerebral or brain stem origin. 423 C191385 Symptoms and Signs Yes C191398 Current Symptoms and Signs: Clinical Symptoms ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 424 C191385 Symptoms and Signs No C191398 Current Symptoms and Signs: Clinical Symptoms C49487 No The non-affirmative response to a question. 425 C191385 Symptoms and Signs Unknown C191398 Current Symptoms and Signs: Clinical Symptoms A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 426 C191385 Symptoms and Signs Rash || Skin rash C191398 Current Symptoms and Signs: Clinical Symptoms Any change in the skin that affects its appearance or texture. A rash may be localized to one part of the body or affect all the skin. Rashes may cause the skin to change color, itch, become warm, bumpy, dry, cracked, or blistered, swell, and may be painful. C39594 Skin Rash Cutaneous Eruption Any change in the skin which affects its appearance or texture. A rash may be localized to one part of the body, or affect all the skin. Rashes may cause the skin to change color, itch, become warm, bumpy, dry, cracked or blistered, swell and may be painful. 427 C191385 Symptoms and Signs Yes C191398 Current Symptoms and Signs: Clinical Symptoms ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 428 C191385 Symptoms and Signs No C191398 Current Symptoms and Signs: Clinical Symptoms C49487 No The non-affirmative response to a question. 429 C191385 Symptoms and Signs Unknown C191398 Current Symptoms and Signs: Clinical Symptoms A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 430 C191385 Symptoms and Signs Limb edema || Peripheral Edema C191398 Current Symptoms and Signs: Clinical Symptoms Increased tissue fluid indicated by perceptible indentation on lower leg or foot after palpation C78262 Edema Limbs Limb Edema || Peripheral Edema Swelling due to an excessive accumulation of fluid in the upper or lower extremities. 431 C191385 Symptoms and Signs Yes C191398 Current Symptoms and Signs: Clinical Symptoms ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 432 C191385 Symptoms and Signs No C191398 Current Symptoms and Signs: Clinical Symptoms C49487 No The non-affirmative response to a question. 433 C191385 Symptoms and Signs Unknown C191398 Current Symptoms and Signs: Clinical Symptoms A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 434 C191385 Symptoms and Signs Myalgias C191398 Current Symptoms and Signs: Clinical Symptoms Painful sensation originating from a muscle or group of muscles C27009 Myalgia Muscle Ache Painful sensation originating from a muscle or group of muscles. 435 C191385 Symptoms and Signs Yes C191398 Current Symptoms and Signs: Clinical Symptoms ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 436 C191385 Symptoms and Signs No C191398 Current Symptoms and Signs: Clinical Symptoms C49487 No The non-affirmative response to a question. 437 C191385 Symptoms and Signs Unknown C191398 Current Symptoms and Signs: Clinical Symptoms A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 438 C191385 Symptoms and Signs Headache C191398 Current Symptoms and Signs: Clinical Symptoms Pain in any region of the head C34661 Headache Cephalalgia || Cephalgia Pain in various parts of the head, not confined to the area of distribution of any nerve. 439 C191385 Symptoms and Signs Yes C191398 Current Symptoms and Signs: Clinical Symptoms ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 440 C191385 Symptoms and Signs No C191398 Current Symptoms and Signs: Clinical Symptoms C49487 No The non-affirmative response to a question. 441 C191385 Symptoms and Signs Unknown C191398 Current Symptoms and Signs: Clinical Symptoms A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 442 C191385 Symptoms and Signs Altered mental state C191398 Current Symptoms and Signs: Clinical Symptoms A change to an individual's judgment, orientation (to place, time, and self), intellectual functioning, or mood from their baseline C121628 Altered Mental Status A change to an individual's judgment, orientation (to place, time, and self), intellectual functioning, or mood from their baseline. 443 C191385 Symptoms and Signs Yes C191398 Current Symptoms and Signs: Clinical Symptoms ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 444 C191385 Symptoms and Signs No C191398 Current Symptoms and Signs: Clinical Symptoms C49487 No The non-affirmative response to a question. 445 C191385 Symptoms and Signs Unknown C191398 Current Symptoms and Signs: Clinical Symptoms A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 446 C191385 Symptoms and Signs Heart rate || Vital Signs - Heart Rate C191402 Physical Examination A measurement that describes the frequency of rate of contractions of the systemic (often left) ventricle measured within a unit time. C49677 Heart Rate HR The number of heartbeats per unit of time, usually expressed as beats per minute. 447 C191385 Symptoms and Signs bpm C191402 Physical Examination C49673 Beats per Minute Beats/Minute || Heart Beats per Minute The number of heartbeats measured per minute time. 448 C191385 Symptoms and Signs Unknown C191402 Physical Examination A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 449 C191385 Symptoms and Signs Systolic blood pressure C191402 Physical Examination Systolic blood pressure value recorded closest to the time of presentation to the health care facility C25298 Systolic Blood Pressure Systolic Pressure The maximum pressure exerted into the systemic arterial circulation during the contraction of the left ventricle of the heart. 450 C191385 Symptoms and Signs mmHg C191402 Physical Examination C49670 Millimeter of Mercury Torr A non-SI unit of pressure equal to 133,332 Pa or 1.316E10-3 standard atmosphere. Use of this unit is generally deprecated by ISO and IUPAC. 451 C191385 Symptoms and Signs Unknown C191402 Physical Examination A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 452 C191385 Symptoms and Signs Diastolic blood pressure C191402 Physical Examination Diastolic blood pressure value recorded closest to the time of presentation to the health care facility C25299 Diastolic Blood Pressure Diastolic Pressure The minimum pressure exerted into the systemic arterial circulation during cardiac ventricular relaxation and filling. 453 C191385 Symptoms and Signs mmHg C191402 Physical Examination C49670 Millimeter of Mercury Torr A non-SI unit of pressure equal to 133,332 Pa or 1.316E10-3 standard atmosphere. Use of this unit is generally deprecated by ISO and IUPAC. 454 C191385 Symptoms and Signs Unknown C191402 Physical Examination A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 455 C191385 Symptoms and Signs Pulse pressure C191402 Physical Examination The force of a heart contraction measured by the difference between the diastolic and systolic blood pressure measurements C100945 Pulse Pressure The force of a heart contraction measured by the difference between the diastolic and systolic blood pressure measurements. 456 C191385 Symptoms and Signs mmHg C191402 Physical Examination C49670 Millimeter of Mercury Torr A non-SI unit of pressure equal to 133,332 Pa or 1.316E10-3 standard atmosphere. Use of this unit is generally deprecated by ISO and IUPAC. 457 C191385 Symptoms and Signs Unknown C191402 Physical Examination A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 458 C191385 Symptoms and Signs Respiratory rate || Vital Signs - Respiratory Rate C191402 Physical Examination A measurement that describes the rate of breathing (inhalation and exhalation) measured within a unit time (typically 1 min) C49678 Respiratory Rate The rate of breathing (inhalation and exhalation) measured within in a unit time, usually expressed as breaths per minute. 459 C191385 Symptoms and Signs cycles/min C191402 Physical Examination C49674 Breaths per Minute Breaths/Minute The number of breaths (inhalation and exhalation) taken per minute time. 460 C191385 Symptoms and Signs Unknown C191402 Physical Examination A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 461 C191385 Symptoms and Signs Height C191402 Physical Examination A measurement that describes the vertical measurement or distance from the base, or bottom, of the patient, to the top of the patient; this can be taken as the dimension of extension of a patient who cannot stand. C164634 Body Height The vertical measurement or distance from the base to the top of a subject or participant. 462 C191385 Symptoms and Signs cm C191402 Physical Examination C49668 Centimeter A basic unit of length in the former CGS version of metric system, equal to one hundredth of a meter or approximately 0.393 700 787 inch. 463 C191385 Symptoms and Signs Unknown C191402 Physical Examination A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 464 C191385 Symptoms and Signs Vital Signs - Weight || Weight at encounter C191402 Physical Examination A measurement that describes the vertical force exerted by a mass of the patient as a result of gravity C81328 Body Weight The weight of a subject. 465 C191385 Symptoms and Signs kg C191402 Physical Examination C28252 Kilogram A basic SI unit of mass. It is defined as the mass of an international prototype in the form of a platinum-iridium cylinder kept at Sevres in France. A kilogram is equal to 1,000 grams and 2.204 622 6 pounds. 466 C191385 Symptoms and Signs Unknown C191402 Physical Examination A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 467 C191385 Symptoms and Signs Body mass index || Vital Signs - BMI C191402 Physical Examination A measurement that is used to indicate the body fat an individual is carrying based on the ratio of weight to height as measured in kilograms per square meters C16358 Body Mass Index Quetelet Index An individual's weight in kilograms divided by the square of the height in meters. 468 C191385 Symptoms and Signs kg/mg2 C191402 Physical Examination C49671 Kilogram per Square Meter Kilogram per Meter Squared || Kilogram/Square Meter The SI derived unit of spread rate of a substance by mass, used also as a measure of area density and as a dose calculation unit. 469 C191385 Symptoms and Signs Unknown C191402 Physical Examination A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 470 C191385 Symptoms and Signs Jugular venous pressure C191402 Physical Examination The estimated height of the mean jugular venous waveform above the right atrium, measured at a 45 degree angle. When expressed in cm without further description, the number should be recorded as written. When it is expressed as cm above the sternal angle, 5 cm should be added to the number recorded. C191459 Jugular Venous Pressure JVP The estimated height of the mean jugular venous waveform above the right atrium, as measured by observation of the bifid pulsation while the patient is supine and their neck is inclined at a 45 degree angle. 471 C191385 Symptoms and Signs cm C191402 Physical Examination C49668 Centimeter A basic unit of length in the former CGS version of metric system, equal to one hundredth of a meter or approximately 0.393 700 787 inch. 472 C191385 Symptoms and Signs Unknown C191402 Physical Examination A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 473 C191385 Symptoms and Signs Jugular venous distension C191402 Physical Examination Increased pressure of the superior vena cava causing the jugular vein to bulge, making it visualized at a level of the neck that is higher than normal C191482 Jugular Venous Distension JVD Bulging of the jugular vein secondary to increased pressure of the superior vena cava, causing it to be visualized at a level of the neck that is higher than normal. 474 C191385 Symptoms and Signs Yes C191402 Physical Examination ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 475 C191385 Symptoms and Signs No C191402 Physical Examination C49487 No The non-affirmative response to a question. 476 C191385 Symptoms and Signs Unknown C191402 Physical Examination A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 477 C191385 Symptoms and Signs Hepatojugular reflex C191402 Physical Examination Distension of the neck veins precipitated by the maneuver of firm sustained pressure over the liver. Also referred to as abdomino-jugular reflux. C191481 Hepatojugular Reflex Abdominojugular Reflex Distension of the neck veins precipitated by sustained pressure over the liver while patient is semi-recumbent. With normal heart function, pressure on the liver does not elevate the venous blood level in the neck veins. 478 C191385 Symptoms and Signs Yes C191402 Physical Examination ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 479 C191385 Symptoms and Signs No C191402 Physical Examination C49487 No The non-affirmative response to a question. 480 C191385 Symptoms and Signs Unknown C191402 Physical Examination A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 481 C191385 Symptoms and Signs S3 || Third heart sound (S3) C191402 Physical Examination An auscultated finding describing a low-frequency sound that follows A2 in early diastole and corresponds with the first phase of rapid ventricular filling, signifying the third heart sound. It is normal in children and young adults, but abnormal in others. C61455 S3 Gallop S3 Heart Sound || Third Heart Sound || Ventricular Gallop A finding which can be heard on auscultation of the heart in the setting of congestive heart failure. The sound of the S3 gallop, which immediately follows the second heart sound (S2) is thought to be produced by the sound of blood flowing into a noncompliant ventricle. 482 C191385 Symptoms and Signs Yes C191402 Physical Examination ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 483 C191385 Symptoms and Signs No C191402 Physical Examination C49487 No The non-affirmative response to a question. 484 C191385 Symptoms and Signs Unknown C191402 Physical Examination A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 485 C191385 Symptoms and Signs Fourth heart sound (S4) || S4 C191402 Physical Examination An auscultated finding that describes a low-frequency sound, heard late in diastole just before S1, caused by forceful atrial contractions, signifying the fourth heart sound. It is typically abnormal, except in highly trained athletes and the elderly. C168026 S4 Heart Sound An auscultated finding that describes a low-frequency sound, heard late in diastole just before S1, caused by forceful atrial contractions, signifying the fourth heart sound. It is typically abnormal, except in highly trained athletes and the elderly. (ACC/AHA) 486 C191385 Symptoms and Signs Yes C191402 Physical Examination ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 487 C191385 Symptoms and Signs No C191402 Physical Examination C49487 No The non-affirmative response to a question. 488 C191385 Symptoms and Signs Unknown C191402 Physical Examination A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 489 C191385 Symptoms and Signs Rub C191402 Physical Examination An auscultated finding describing high or medium pitched and scratchy sound, generated by inflammation of the pericardial sac C168025 Pericardial Rub An auscultated finding describing high or medium pitched and scratchy sound, generated by inflammation of the pericardial sac. (ACC/AHA) 490 C191385 Symptoms and Signs Yes C191402 Physical Examination ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 491 C191385 Symptoms and Signs No C191402 Physical Examination C49487 No The non-affirmative response to a question. 492 C191385 Symptoms and Signs Unknown C191402 Physical Examination A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 493 C191385 Symptoms and Signs Heart murmur || Murmur C191402 Physical Examination An auscultated finding describing a series of audible vibrations of varying intensity (loudness), frequency (pitch), quality, configuration, and duration created by turbulent blood flow in the heart or surrounding vessels C84480 Heart Murmur Cardiac Murmur A periodic humming or blowing sound heard on auscultation of the heart that can indicate the presence of cardiac disease; murmurs are the result of vibrations caused by the turbulent flow of blood in the heart or great vessels. Murmurs are characterized according to the area of generation (mitral, aortic, tricuspid, or pulmonary) and according to the period of the cycle (systolic or diastolic). 494 C191385 Symptoms and Signs Yes C191402 Physical Examination ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 495 C191385 Symptoms and Signs No C191402 Physical Examination C49487 No The non-affirmative response to a question. 496 C191385 Symptoms and Signs Unknown C191402 Physical Examination A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 497 C191385 Symptoms and Signs Cardiac Examination - Heart Sounds, Phase of Murmur || Heart murmur timing C191402 Physical Examination The classification of a heart murmur based on the phase of the cardiac cycle or timing of its occurrence C167438 Heart Murmur Categorized by Phase or Timing The classification of a heart murmur based on the phase of the cardiac cycle or timing of its occurrence. 498 C191385 Symptoms and Signs Systolic C191402 Physical Examination The phase of time during ventricular ejection in which the semilunar valve(s) are open. C167437 Systolic Heart Murmur Systolic Murmur A heart murmur that occurs during ventricular ejection, while the semilunar valves are open. 499 C191385 Symptoms and Signs Diastolic C191402 Physical Examination The phase of time between ventricular ejection, in which the semilunar valve(s) are closed. C167445 Diastolic Heart Murmur Diastolic Murmur A heart murmur that occurs between ventricular ejection, while the semilunar valves are closed. 500 C191385 Symptoms and Signs Cardiac Examination - Heart Sounds, Location (Including Murmurs) || Heart sounds - location (including murmurs) C191402 Physical Examination The classification of a heart murmur based on location C168320 Location of Heart Sound Auscultation The location on the anterior chest wall where auscultation is undertaken. 501 C191385 Symptoms and Signs Apex C191402 Physical Examination The location on the precordium that corresponds to the location of the blunt extremity of the heart formed by the left ventricle. C168234 Heart Sound Auscultation at Apex Heart sounds are auscultated on the precordial location corresponding to the blunt extremity of the heart formed by the left ventricle. 502 C191385 Symptoms and Signs Left lower sternal border C191402 Physical Examination The location on the precordium that corresponds to the tricuspid region, between the fifth and sixth intercostal spaces at the left sternal border C168238 Heart Sound Auscultation at Left Lower Sternal Border Heart sounds are auscultated on the precordial location corresponding to the tricuspid region, between the fifth, and sixth intercostal spaces at the left sternal border. 503 C191385 Symptoms and Signs Left middle sternal border C191402 Physical Examination The location on the precordium that corresponds to the region between the third and fifth intercostal spaces at the left sternal border C168240 Heart Sound Auscultation at Left Middle Sternal Border Heart sounds are auscultated on the precordial location corresponding to the region between the third and fifth intercostal spaces at the left sternal border. 504 C191385 Symptoms and Signs Left upper sternal border C191402 Physical Examination The location on the precordium that corresponds to the pulmonic region, between the second and third intercostal spaces at the left sternal border C168241 Heart Sound Auscultation at Left Upper Sternal Border Heart sounds are auscultated on the precordial location corresponding to the pulmonic region, between the second and third intercostal spaces at the left sternal border. 505 C191385 Symptoms and Signs Right upper sternal border C191402 Physical Examination The location on the precordium that corresponds to the aortic region, between the second and third intercostal spaces at the right sternal border C168247 Heart Sound Auscultation at Right Upper Sternal Border Heart sounds are auscultated on the precordial location corresponding to the aortic region, between the second and third intercostal spaces at the right sternal border. 506 C191385 Symptoms and Signs Lung (pulmonary) examination findings C191402 Physical Examination Findings on auscultation of the lungs C191427 Lung Examination Finding Pulmonary Examination Finding A finding noted on auscultation of the lungs. 507 C191385 Symptoms and Signs Clear or normal C191402 Physical Examination Lungs are normal on auscultation. C191568 Lungs Clear on Auscultation Normal breath sounds noted during auscultation. 508 C191385 Symptoms and Signs Rales C191402 Physical Examination Abnormal breath sounds (crackles) heard on auscultation indicating inflammation, fluid, or infection of the lung C119216 Rales Pulmonary Rales Abnormal breath sounds (crackles) heard on auscultation, indicating inflammation, fluid, or infection of the lung. 509 C191385 Symptoms and Signs Decreased breath sounds or dullness C191402 Physical Examination Diminished breath sounds C191569 Decreased Breath Sounds Diminished breath sounds noted during auscultation. 510 C191385 Symptoms and Signs Rhonchi C191402 Physical Examination Abnormal breath sounds similar to snoring heard on auscultation of the bronchial airways, suggesting a partial obstruction due to thick secretions, a muscular spasm, or a neoplasm C87116 Rhonchi An abnormal sound similar to snoring heard on auscultation of the bronchial airways, suggesting a partial obstruction due to thick secretions, a muscular spasm, or a neoplasm. 511 C191385 Symptoms and Signs Wheezing C191402 Physical Examination A clinical finding in which there is a raspy high-pitched whistling sound noted on expiration or inspiration associated with obstruction of the lower airways. C78718 Wheezing Wheeze A symptom and a finding during physical examination, characterized by a high-pitched, whistling sound during breathing. It results from the narrowing or obstruction of the respiratory airways. The most common causes of wheezing are asthma, chronic obstructive pulmonary disease, tracheobronchitis, and pulmonary edema. 512 C191385 Symptoms and Signs Crepitations C191402 Physical Examination Crackling sounds typically heard in lung infection or with pulmonary fibrosis C61454 Basilar Rales Crackles Abnormal breath sounds (crackles) heard on auscultation only in the bases of the lungs. They indicate inflammation, fluid, or infection in the air sacs of the lung. 513 C191385 Symptoms and Signs Pleural friction rub C191402 Physical Examination An abnormal lung sound that is caused by inflammation of the pleural layer of the lungs rubbing together. Pleural friction rub is heard on inspiration and expiration and sounds like a low-pitch harsh/grating noise. C191616 Pleural Friction Rub A low-pitch harsh, grating sound heard on auscultation of the lungs during inspiration and expiration that is caused by inflamed pleura layers rubbing together. 514 C191385 Symptoms and Signs Absent breath sounds C191402 Physical Examination Absence of breath sounds during auscultation C191570 Absent Breath Sounds Absence of breath sounds noted during auscultation. 515 C191385 Symptoms and Signs Other findings C191402 Physical Examination C36295 An additional finding not previously noted. 516 C191385 Symptoms and Signs Limb edema || Peripheral Edema C191402 Physical Examination Increased tissue fluid indicated by perceptible indentation on lower leg or foot after palpation C78262 Edema Limbs Limb Edema || Peripheral Edema Swelling due to an excessive accumulation of fluid in the upper or lower extremities. 517 C191385 Symptoms and Signs Yes C191402 Physical Examination ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 518 C191385 Symptoms and Signs No C191402 Physical Examination C49487 No The non-affirmative response to a question. 519 C191385 Symptoms and Signs Unknown C191402 Physical Examination A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 520 C191385 Symptoms and Signs Ascites C191402 Physical Examination A clinical finding in which there is accumulation of interstitial fluid in the peritoneal cavity. C2885 Ascites The accumulation of fluid in the peritoneal cavity, which may be serous, hemorrhagic, or the result of tumor metastasis to the peritoneum. 521 C191385 Symptoms and Signs Yes C191402 Physical Examination ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 522 C191385 Symptoms and Signs No C191402 Physical Examination C49487 No The non-affirmative response to a question. 523 C191385 Symptoms and Signs Unknown C191402 Physical Examination A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 524 C191385 Symptoms and Signs Hepatomegaly C191402 Physical Examination A clinical finding in which the liver is found to be enlarged on abdominal palpation. C3100 Hepatomegaly Abnormal enlargement of the liver. 525 C191385 Symptoms and Signs Yes C191402 Physical Examination ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 526 C191385 Symptoms and Signs No C191402 Physical Examination C49487 No The non-affirmative response to a question. 527 C191385 Symptoms and Signs Unknown C191402 Physical Examination A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 528 C191385 Symptoms and Signs Neurological examination findings C191402 Physical Examination C191598 Neurological Examination Finding Neurologic Examination Finding A finding noted on examination of the functioning of the nervous system. 529 C191385 Symptoms and Signs Dizziness C191402 Physical Examination A condition in which the sensation of lightheadedness or a feeling of movement within the head occurs. C37943 Dizziness Dizzy A sensation of lightheadedness, unsteadiness, turning, spinning or rocking. 530 C191385 Symptoms and Signs Headache C191402 Physical Examination Pain in any region of the head C34661 Headache Cephalalgia || Cephalgia Pain in various parts of the head, not confined to the area of distribution of any nerve. 531 C191385 Symptoms and Signs Impaired consciousness C191402 Physical Examination C121627 Altered Level of Consciousness Altered LOC A level of awareness and arousal other than normal. 532 C191385 Symptoms and Signs Seizure || Seizures C191402 Physical Examination Convulsions, sensory, cognitive disturbances, or loss of consciousness resulting from abnormal electrical discharges in the brain in a patient with probable or confirmed COVID-19 C2962 Seizure Convulsion Sudden, involuntary skeletal muscular contractions of cerebral or brain stem origin. 533 C191385 Symptoms and Signs Agitation C191402 Physical Examination C79530 Agitation A state of restlessness associated with unpleasant feelings of irritability and tension. Causes include pain, stress, fever, alcohol and nicotine withdrawal, cocaine and hallucinogenic drugs use, depression, bipolar disorders, and schizophrenia. 534 C191385 Symptoms and Signs Confusion C191402 Physical Examination C37928 Confusion Disorientation A mental state characterized by a lack of clear and orderly thought and behavior. 535 C191385 Symptoms and Signs Visual agnosia C191402 Physical Examination C35276 Visual Agnosia An inability to recognize or interpret objects by sight. 536 C191385 Symptoms and Signs Encephalopathy C191402 Physical Examination C26920 Encephalopathy A functional and/or structural disorder of the brain caused by diseases (e.g. liver disease, kidney disease), medications, chemicals, and injuries. 537 C191385 Symptoms and Signs Acute cerebrovascular accident C191402 Physical Examination C191433 Acute Stroke The sudden or severe onset of neurological deficit(s) attributable to an acute focal vascular injury of the central nervous system. 538 C191385 Symptoms and Signs Corticospinal tract signs: enhanced tendon reflexes C191402 Physical Examination C191580 Enhanced Tendon Reflex Greater than normal deep tendon reflexes. 539 C191385 Symptoms and Signs Corticospinal tract signs: clonus C191402 Physical Examination C34484 Clonus A form of involuntary muscular movement characterized by alternating contractions and relaxation in rapid succession. In the context of reflex testing, the ability to elicit clonus indicates injury to the nerve tracts above the point at which the reflex was initiated. 540 C191385 Symptoms and Signs Corticospinal tract signs: hyperreflexia C191402 Physical Examination C43248 Hyperreflexia Autonomic nervous system overreaction to stimuli, most commonly after spinal cord injury at a T-5 level and above. 541 C191385 Symptoms and Signs Stroke || Stroke not otherwise specified C191402 Physical Examination An episode of acute neurological dysfunction presumed to be caused by ischemia or hemorrhage, persisting greater than or equal to 24 h or until death but without sufficient evidence to be classified as one of the above C3390 Stroke Cerebrovascular Accident || Stroke Syndrome A sudden loss of neurological function secondary to hemorrhage or ischemia in the brain parenchyma due to a vascular event. 542 C191385 Symptoms and Signs Guillain-Barré syndrome C191402 Physical Examination C116345 Guillain-Barre Syndrome Guillain Barre Syndrome || Guillain Barré Syndrome || Guillain-Barré Syndrome A rapidly progressive autoimmune disorder of the peripheral nervous system characterized by limb paresthesias, areflexia, and generalized muscle weakness or paralysis that often begins in the legs and spreads to the arms, torso, and face. 543 C191385 Symptoms and Signs Critical illness myopathy C191402 Physical Examination C122793 Critical Illness Myopathy Acute muscle weakness and paralysis that develops in critically ill patients who have been treated with multiple drugs during their intensive care unit stay. It is associated with delayed weaning from mechanical ventilation and prolonged rehabilitation. 544 C191385 Symptoms and Signs Critical illness polyneuropathy C191402 Physical Examination C191601 Critical Illness Polyneuropathy Polyneuropathy arising in intensive care unit patients. It is a common complication of severe sepsis and is thought to represent a neurologic manifestation of systemic inflammatory response syndrome (SIRS). 545 C191385 Symptoms and Signs Critical illness polyneuropathy/myopathy C191402 Physical Examination C191600 Critical Illness Polyneuromyopathy Polyneuropathy and myopathy arising in intensive care unit patients. 546 C191385 Symptoms and Signs Miller-Fisher syndrome C191402 Physical Examination C116958 Miller Fisher Syndrome Fisher Syndrome An autoimmune process characterized by the clinical triad of ophthalmoplegia, ataxia, and areflexia. 547 C191385 Symptoms and Signs Other, specify C191402 Physical Examination C157106 Specify Other A directive to indicate a response not listed. 548 C191385 Symptoms and Signs Frailty C191402 Physical Examination Canadian Study of Health and Aging Clinical Frailty Scale score C185373 Clinical Frailty Scale CFS A judgement-based tool to screen for frailty and to broadly stratify degrees of fitness and frailty in elderly people. 549 C191385 Symptoms and Signs 1 (very fit) C191402 Physical Examination People who are robust, active, energetic, and motivated. These people commonly exercise regularly. They are among the fittest for their age. C191486 Clinical Frailty Scale Category 1 A Clinical Frailty Scale category that indicates that an individual is very fit. People who are robust, active, energetic, and motivated. These people commonly exercise regularly. They are among the fittest for their age. 550 C191385 Symptoms and Signs 2 (well) C191402 Physical Examination People who have no active disease symptoms but are less fit than category 1. Often, they exercise or are very active occasionally (e.g., seasonally) C191487 Clinical Frailty Scale Category 2 A Clinical Frailty Scale category that indicates that an individual is fit or well. People who have no active disease symptoms but are less fit than category 1. Often, they exercise or are very active occasionally (e.g., seasonally). 551 C191385 Symptoms and Signs 3 (managing well) C191402 Physical Examination People whose medical problems are well controlled but are not regularly active beyond routine walking C191488 Clinical Frailty Scale Category 3 A Clinical Frailty Scale category that indicates that an individual is managing well. People whose medical problems are well controlled but are not regularly active beyond routine walking. 552 C191385 Symptoms and Signs 4 (vulnerable) C191402 Physical Examination Although not dependent on others for daily help, symptoms often limit activities. A common complaint is being "slowed up" or being tired during the day. C191489 Clinical Frailty Scale Category 4 A Clinical Frailty Scale category that indicates that an individual is living with very mild frailty. Previously denoted as "vulnerable", this category marks the transition from complete independence. Although not dependent on others for daily help, symptoms often limit activities. A common complaint is being "slowed up" or being tired during the day. 553 C191385 Symptoms and Signs 5 (mildly frail) C191402 Physical Examination These people often have more evident slowing and need help in high-order instrumental activities of daily living (finances, transportation, heavy housework, medications). Typically, mild frailty progressively impairs shopping and walking outside alone, meal preparation, and housework. C191490 Clinical Frailty Scale Category 5 A Clinical Frailty Scale category that indicates that an individual is living with mild frailty. These people often have more evident slowing and need help in high-order instrumental activities of daily living (finances, transportation, heavy housework, medications). Typically, mild frailty progressively impairs shopping and walking outside alone, meal preparation, and housework. 554 C191385 Symptoms and Signs 6 (moderately frail) C191402 Physical Examination People need help with all outside activities and with keeping house. Inside, they often have problems with stairs and need help with bathing and might need minimal assistance (cueing, standby) with dressing. C191491 Clinical Frailty Scale Category 6 A Clinical Frailty Scale category that indicates that an individual is living with moderate frailty. People need help with all outside activities and with keeping house. Inside, they often have problems with stairs and need help with bathing and might need minimal assistance (cueing, standby) with dressing. 555 C191385 Symptoms and Signs 7 (severely frail) C191402 Physical Examination Completely dependent for personal care, from whatever cause (physical or cognitive). Even so, they seem stable and not at high risk of dying (within ~6 mo). C191492 Clinical Frailty Scale Category 7 A Clinical Frailty Scale category that indicates that an individual is living with severe frailty. Completely dependent for personal care, from whatever cause (physical or cognitive). Even so, they seem stable and not at high risk of dying (within about 6 months). 556 C191385 Symptoms and Signs 8 (very severely frail) C191402 Physical Examination Completely dependent, approaching the end of life. Typically, they could not recover even from a minor illness. C191493 Clinical Frailty Scale Category 8 A Clinical Frailty Scale category that indicates that an individual is living with very severe frailty. Completely dependent, approaching the end of life. Typically, they could not recover even from a minor illness. 557 C191385 Symptoms and Signs 9 (terminally ill) C191402 Physical Examination Approaching the end of life. This category applies to people with a life expectancy <6 mo, who are not otherwise evidently frail. C191494 Clinical Frailty Scale Category 9 A Clinical Frailty Scale category that indicates that an individual is terminally ill. Approaching the end of life. This category applies to people with a life expectancy of less than 6 months, who are not otherwise evidently frail. Many terminally ill patients can still exercise until very close to death. 558 C191386 Diagnostic Procedures EF, quantitative Proportion of blood pumped out of the left ventricle of the heart with each contraction, expressed as a percentage C80417 Ejection Fraction, Quantitative The percentage computed when the amount of blood ejected during a ventricular contraction of the heart is compared to the amount that was present prior to the contraction. 559 C191386 Diagnostic Procedures EF, % The fraction of blood expelled from the left ventricle with each cardiac systole (stroke volume/end diastolic volume) C99524 Left Ventricular Ejection Fraction The fraction of the left ventricular end diastolic volume ejected with each beat. The left ventricular ejection fraction is equal to the left ventricular stroke volume divided by the left ventricular end diastolic volume. 560 C191386 Diagnostic Procedures EF, qualitative Proportion of blood pumped out of the left ventricle of the heart with each contraction, expressed as qualitative description. The qualitative estimate of the amount of blood expelled from the left ventricle with each cardiac systole. C80418 Ejection Fraction, Qualitative A descriptive adjective assigned to the computed amount of blood ejected during a ventricular contraction of the heart. 561 C191386 Diagnostic Procedures Normal (i.e., greater than or equal to 50%) C99513 Normal Ventricular Ejection Fraction The usual amount of blood that is forced from the heart ventricle to produce cardiac output. Quantitatively, the ejection fraction is considered between 50% to 70%. 562 C191386 Diagnostic Procedures Mildly reduced (i.e., greater than or equal to 40% and less than 50%) C99507 Mildly Abnormal Ejection Fraction Slightly less than normal amount of blood that is forced from the heart ventricle to produce cardiac output. Quantitatively, the ejection fraction is considered between 40% to 49%. 563 C191386 Diagnostic Procedures Moderately reduced (i.e., greater than or equal to 30% and less than 40%) C99508 Moderately Abnormal Ejection Fraction Moderately less than normal amount of blood that is forced from the heart ventricle to produce cardiac output. Quantitatively, the ejection fraction is considered between 30% to 39%. 564 C191386 Diagnostic Procedures Severely reduced (i.e., less than 30%) C99509 Severely Abnormal Ventricular Ejection Fraction Severely less than normal amount of blood that is forced from the heart ventricle to produce cardiac output. Quantitatively, the ejection fraction is considered less than 30%. 565 C191386 Diagnostic Procedures EF modality Modality used to determine the EF C191578 Ejection Fraction Modality EF Modality The modality used to determine the ejection fraction. 566 C191386 Diagnostic Procedures Radionuclide ventriculography A multigated acquisition scan and a form of radionuclide imaging that provides a comprehensive look at blood flow and the function of the lower chambers of the heart ventricles C38073 Multigated Acquisition Scan Blood Pool Scan || Equilibrium Radionuclide Angiography || Gated Blood Pool Imaging || MUGA Scan || Multi-Gated Acquisition Scan || RNVG || Radionuclide Ventriculography || SYMA Scanning || Synchronized Multigated Acquisition Scanning A diagnostic test used to evaluate the pumping function of the heart's ventricles. A radioactive tracer is injected into a vein and a gamma camera detects the radiation released by the tracer, with image acquisition triggered (gated) at different points of the cardiac cycle. 567 C191386 Diagnostic Procedures Cardiac MRI A noninvasive medical imaging technology using magnetic field and radio waves to evaluate the heart's anatomy and function for detection and monitoring of cardiac diseases. C137915 Magnetic Resonance Imaging of the Heart Cardiac MRI || Heart MRI Magnetic resonance imaging of the heart. 568 C191386 Diagnostic Procedures Echocardiography A test that uses high-frequency sound waves (ultrasound) to create an image of the heart C16525 Echocardiography A procedure that uses high-frequency sound waves (ultrasound) to create an image of the heart. 569 C191386 Diagnostic Procedures Invasive contrast left ventriculography A medical imaging test that involves injecting contrast media into the heart's ventricle(s) to determine a patient's cardiac function C124142 Cardiac Ventriculography A medical imaging test that involves injecting contrast media into the heart's ventricle(s) to determine a patient's cardiac function. 570 C191386 Diagnostic Procedures Myocardial perfusion imaging An imaging procedure that quantifies blood flow throughout the heart muscle C102676 Myocardial Perfusion Imaging A procedure that captures pictures of blood flow throughout the heart muscle. 571 C191386 Diagnostic Procedures Other A proper value is applicable but not known. C17649 Other Other or Miscellaneous Different than the one(s) previously specified or mentioned. 572 C191386 Diagnostic Procedures Echocardiography data elements Refer to the 2019 ACC/AHA/ASE Key Data Elements and Definitions for Transthoracic Echocardiography. C191523 Echocardiography Data Element A data element that is used in the reporting of echocardiography. 573 C191386 Diagnostic Procedures Electrocardiography elements 12-lead electrocardiography data elements C191524 Electrocardiography Data Element A data element that is used in the reporting of electrocardiography. 574 C191386 Diagnostic Procedures Rhythm C87081 Heart Rhythm Cardiac Rhythm The recurrent, measured movements (rhythm) of a beating heart. 575 C191386 Diagnostic Procedures Sinus Rhythm an electrocardiographic finding of a cardiac rhythm that originates in the sinoatrial node C100076 Sinus Rhythm An electrocardiographic finding of an atrial rhythm which originates from the sinoatrial node that is considered normal for the population. (CDISC) 576 C191386 Diagnostic Procedures AF an arrhythmia characterized by uncoordinated atrial myocardium due to multiple reentry circuits with consequent deterioration of atrial mechanical function. Instead of intermittently contracting, the atria quiver continuously in a chaotic pattern, causing a totally irregular often tachycardic ventricular rate C111092 Atrial Fibrillation by ECG Finding Atrial Fibrillation || Atrial Fibrillation by EKG Finding An electrocardiographic finding of a supraventricular arrhythmia characterized by the replacement of consistent P waves by rapid oscillations or fibrillatory waves that vary in size, shape and timing and are accompanied by an irregularly irregular ventricular response. (CDISC) 577 C191386 Diagnostic Procedures Atrial flutter a disorder characterized by an electrocardiographic finding of an organized, regular atrial rhythm with atrial rate of 240-340 bpm. Multiple P waves typically appear in the inferior leads in a sawtooth-like pattern between the QRS complexes. C111094 Atrial Flutter by ECG Finding Atrial Flutter || Atrial Flutter by EKG Finding An electrocardiographic finding of an organized, regular atrial rhythm with atrial rate of 240-340 beats per minute. Multiple P waves typically appear in the inferior leads in a saw tooth like pattern between the QRS complexes. (CDISC) 578 C191386 Diagnostic Procedures Ventricular arrhythmia a disorder characterized by an electrocardiographic finding of an atypical cardiac rhythm resulting from a pathological process in the cardiac ventricles C111101 Ventricular Arrhythmia by ECG Finding Ventricular Arrhythmia || Ventricular Arrhythmia by EKG Finding An electrocardiographic finding of an atypical cardiac rhythm resulting from a pathologic process in the cardiac ventricles. 579 C191386 Diagnostic Procedures Supraventricular tachycardia a disorder characterized by an electrocardiographic finding of a tachycardia that does not originate in the ventricles or His Purkinje system C111100 Supraventricular Tachycardia by ECG Finding Supraventricular Tachycardia || Supraventricular Tachycardia by EKG Finding An electrocardiographic finding of a tachycardia which does not originate in the ventricles or His Purkinje system. There is an abnormally high heart rate and QRS complexes are typically narrow, but aberration or preexcitation may be present. (CDISC) 580 C191386 Diagnostic Procedures Paced rhythm an electrocardiographic finding that the cardiac rhythm is initiated by an electrical impulse from a mechanical cardiac pacemaker C88140 Paced Rhythm An electrocardiographic finding in which the cardiac rhythm is controlled by an electrical impulse from an artificial cardiac pacemaker. (CDISC) 581 C191386 Diagnostic Procedures Other A proper value is applicable but not known. C17649 Other Other or Miscellaneous Different than the one(s) previously specified or mentioned. 582 C191386 Diagnostic Procedures Heart rate || Vital Signs - Heart Rate A measurement that describes the frequency of rate of contractions of the systemic (often left) ventricle measured within a unit time. C49677 Heart Rate HR The number of heartbeats per unit of time, usually expressed as beats per minute. 583 C191386 Diagnostic Procedures QRS axis A numerical representation of the electrocardiographic vector assessed at maximum deviation of the QRS complex from the isoelectric baseline, usually reported for the frontal plane C118165 QRS Axis A numerical representation of the electrocardiographic vector assessed at maximum deviation of the QRS complex from the isoelectric baseline, usually reported for the frontal plane. (CDISC) 584 C191386 Diagnostic Procedures LBBB An electrocardiographic finding of delayed conduction to the left ventricle, manifested as a widened QRS complex and absence of Q waves in leads V5, V6, I, and aVL with QRS duration greater than or equal to 120 ms C62269 Left Bundle Branch Block by ECG Finding LBBB || Left Bundle Branch Block || Left Bundle Branch Block by EKG Finding An electrocardiographic finding of a wide QRS complex with evidence of delayed conduction to the left ventricle, manifested as a widened initial portion of the QRS complex in leads V5, V6, I and aVL and with QRS duration greater than or equal to 120 ms. (CDISC) 585 C191386 Diagnostic Procedures RBBB An electrocardiographic finding of delayed conduction to the right ventricle, manifested by a widened QRS in V1 and V2, a widened S wave in V5, V6, I and aVL, and with QRS duration greater than or equal to 120 ms. An RsR' complex is typically present in leads V1 and V2 C62270 Right Bundle Branch Block by ECG Finding RBBB || Right Bundle Branch Block || Right Bundle Branch Block by EKG Finding An electrocardiographic finding of a wide QRS complex with evidence of delayed conduction to the right ventricle, manifested by a widened initial portion of the QRS in V1 and V2, a widened S wave in V5, V6, I and aVL, and with QRS duration greater than or equal to 120 ms. An RsR' complex is typically present in leads V1 and V2. (CDISC) 586 C191386 Diagnostic Procedures Nonspecific intraventricular conduction delay An electrocardiographic finding of a widened QRS duration typically >110 ms that does not meet the morphological criteria for any of the standard bundle branch or fascicular block patterns C62271 Nonspecific Intraventricular Conduction Delay by ECG Finding IVCD || Nonspecific Intraventricular Conduction Delay || Nonspecific Intraventricular Conduction Delay by EKG Finding An electrocardiographic finding of a widened QRS duration typically greater than 110 ms which does not meet the morphologic criteria for any of the standard bundle branch or fascicular block patterns. (CDISC) 587 C191386 Diagnostic Procedures Presence of abnormal Q waves greater than or equal to 0.03 s in width and greater than or equal to 1 mm (0.1 mV) in depth in at least 2 contiguous leads C191644 Q Wave Abnormality by ECG Finding Q Wave Abnormality || Q Wave Abnormality by EKG Finding An electrocardiographic finding for the Q wave that is atypical for the duration (greater than or equal to 0.03 seconds) and amplitude (greater than or equal to 1 mm (0.1 mV)) in at least 2 contiguous leads. 588 C191386 Diagnostic Procedures Mean QRS duration, ms The mean duration of the QRS interval, obtained from a set of measurements of the QRS interval. The QRS interval is defined as the time from the beginning of the QRS complex to the end of the QRS complex, representing the time it takes for the ventricles to depolarize. C62087 Mean QRS Duration Summary (Mean) QRS Duration The average (mean) duration (time) of the QRS interval, obtained from a set of measurements of the QRS interval. The QRS interval is defined as the time from the beginning of the QRS complex to the end of the QRS complex, representing the time it takes for the ventricles to depolarize. 589 C191386 Diagnostic Procedures PR interval The time interval between the start of the P wave and the beginning of the QRS complex in the cardiac cycle C83502 PR Interval The time interval between the start of the P wave and the beginning of the QRS complex in the cardiac cycle. 590 C191386 Diagnostic Procedures QTc interval The time interval between the start of the Q wave and the end of the T wave in the cardiac cycle as corrected with a nonspecified correction formula C100391 Corrected QT Interval QTc Interval The time interval between the start of the Q wave and the end of the T wave in the cardiac cycle as corrected with a non-specified correction formula. 591 C191386 Diagnostic Procedures AV block An electrocardiographic finding of blocked cardiac electrical impulses along the fibers normally responsible for impulse conduction C26703 Atrioventricular Block by ECG Finding AV Block || Atrioventricular Block || Atrioventricular Block by EKG Finding An electrocardiographic finding of delayed or blocked cardiac electrical impulse conduction from the atria to the ventricles at the level of the atrioventricular node. 592 C191386 Diagnostic Procedures ST segment changes An electrocardiographic finding of ST segment elevation or depression C71026 ST Segment Abnormality by ECG Finding ST Segment Abnormality || ST Segment Abnormality by EKG Finding An electrocardiographic finding of ST segment elevation or depression. 593 C191386 Diagnostic Procedures Chest radiography Documented findings from the radiological examination of the chest (chest x-ray) C38103 Chest Radiography Chest X-ray An x-ray examination of the chest. 594 C191386 Diagnostic Procedures Pulmonary infiltrates Imaging-defined opacification and consolidation of lungs suggesting injury and substance denser than air, such as pus, blood, or protein, within the parenchyma of the lungs during acute COVID-19 C102531 Pulmonary Infiltrate Lung Infiltrate A finding indicating the presence of an inflammatory or neoplastic cellular infiltrate in the lung parenchyma. 595 C191386 Diagnostic Procedures Pulmonary vascular redistribution Distension of the pulmonary veins, particularly in the upper lung fields during acute COVID-19 C191483 Pulmonary Vascular Redistribution Distension of the pulmonary veins, particularly in the upper lung fields. 596 C191386 Diagnostic Procedures Pulmonary congestion Imaging findings consistent with increased intravascular blood volume in the lungs C119217 Pulmonary Congestion by Radiological Technique Imaging findings consistent with increased intravascular blood volume in the lungs. 597 C191386 Diagnostic Procedures Pulmonary edema Accumulation of fluid in the lung tissues C26868 Pulmonary Edema Accumulation of fluid in the lung tissues causing disturbance of the gas exchange that may lead to respiratory failure. It is caused by direct injury to the lung parenchyma or congestive heart failure. The symptoms may appear suddenly or gradually. Suddenly appearing symptoms include difficulty breathing, feeling of suffocation, and coughing associated with frothy sputum. Gradually appearing symptoms include difficulty breathing while lying in bed, shortness of breath during activity, and weight gain (in patients with congestive heart failure). 598 C191386 Diagnostic Procedures Cardiomegaly || Cardiomegaly, chamber enlargement A clinical finding in which the heart is noted to be larger than normal. C61453 Cardiomegaly Abnormal enlargement of the heart. 599 C191386 Diagnostic Procedures Pleural effusion(s) Increased amounts of fluid within the pleural cavity. Symptoms include shortness of breath, cough, and chest pain. It is usually caused by lung infections, congestive HF, pleural and lung tumors, connective tissue disorders, and trauma C3331 Pleural Effusion Increased amounts of fluid within the pleural cavity. Symptoms include shortness of breath, cough, and chest pain. It is usually caused by lung infections, congestive heart failure, pleural and lung tumors, connective tissue disorders, and trauma. 600 C191386 Diagnostic Procedures No abnormalities related to cardiovascular diseases || None C41132 None No person or thing, nobody, not any. 601 C191386 Diagnostic Procedures Chest CT Documented findings from the CT examination of the chest, with or without angiography C191501 Chest Computed Tomography Chest CT || Computed Tomography of the Chest Computed tomography of the chest. 602 C191386 Diagnostic Procedures Pulmonary embolism The obstruction of the pulmonary artery or one of its branches by an embolus, sometimes associated with infarction of the lung, during acute COVID-19 C50713 Pulmonary Embolism The obstruction of the pulmonary artery or one of its branches by an embolus, sometimes associated with infarction of the lung. 603 C191386 Diagnostic Procedures Pulmonary infiltrates Imaging-defined opacification and consolidation of lungs suggesting injury and substance denser than air, such as pus, blood, or protein, within the parenchyma of the lungs during acute COVID-19 C102531 Pulmonary Infiltrate Lung Infiltrate A finding indicating the presence of an inflammatory or neoplastic cellular infiltrate in the lung parenchyma. 604 C191386 Diagnostic Procedures Pulmonary vascular redistribution Distension of the pulmonary veins, particularly in the upper lung fields during acute COVID-19 C191483 Pulmonary Vascular Redistribution Distension of the pulmonary veins, particularly in the upper lung fields. 605 C191386 Diagnostic Procedures Pulmonary congestion Imaging findings consistent with increased intravascular blood volume in the lungs C119217 Pulmonary Congestion by Radiological Technique Imaging findings consistent with increased intravascular blood volume in the lungs. 606 C191386 Diagnostic Procedures Pulmonary edema Accumulation of fluid in the lung tissues C26868 Pulmonary Edema Accumulation of fluid in the lung tissues causing disturbance of the gas exchange that may lead to respiratory failure. It is caused by direct injury to the lung parenchyma or congestive heart failure. The symptoms may appear suddenly or gradually. Suddenly appearing symptoms include difficulty breathing, feeling of suffocation, and coughing associated with frothy sputum. Gradually appearing symptoms include difficulty breathing while lying in bed, shortness of breath during activity, and weight gain (in patients with congestive heart failure). 607 C191386 Diagnostic Procedures Cardiomegaly || Cardiomegaly, chamber enlargement A clinical finding in which the heart is noted to be larger than normal. C61453 Cardiomegaly Abnormal enlargement of the heart. 608 C191386 Diagnostic Procedures Pleural effusion(s) Increased amounts of fluid within the pleural cavity. Symptoms include shortness of breath, cough, and chest pain. It is usually caused by lung infections, congestive HF, pleural and lung tumors, connective tissue disorders, and trauma C3331 Pleural Effusion Increased amounts of fluid within the pleural cavity. Symptoms include shortness of breath, cough, and chest pain. It is usually caused by lung infections, congestive heart failure, pleural and lung tumors, connective tissue disorders, and trauma. 609 C191386 Diagnostic Procedures Thrombus The formation of a blood clot in the lumen of a vessel or heart chamber C27083 Blood Clot Thrombus An aggregation of blood factors, primarily platelets and fibrin with entrapment of cellular elements, frequently causing vascular obstruction at the point of its formation. 610 C191386 Diagnostic Procedures Coronary artery aneurysm Focal dilation of a coronary artery (greater than or equal to 1.5' the adjacent normal segment) C168176 Coronary Artery Aneurysm Focal dilation of a coronary artery secondary to arterial wall weakening. (ACC/AHA) 611 C191386 Diagnostic Procedures No abnormalities related to cardiovascular diseases || None C41132 None No person or thing, nobody, not any. 612 C191386 Diagnostic Procedures CCTA CAD-RADS (Reporting and Data System) score specifically for CCTA, based on degree of maximal coronary stenosis C191422 Coronary Artery Disease Reporting and Data System Coronary CT Angiography Score CAD-RADS CCTA Score A score developed by the Coronary Artery Disease Reporting and Data System (CAD-RADS) to standardize reporting of the extent of coronary artery stenosis in patients undergoing coronary CT angiography (CCTA) and to guide patient management. All vessels greater than 1.5 mm in diameter are assessed for the most clinically relevant (usually highest-grade) stenosis. 613 C191386 Diagnostic Procedures 0 0% C191503 Coronary Artery Disease Reporting and Data System Coronary CT Angiography Score 0 CAD-RADS CCTA Score 0 A Coronary Artery Disease Reporting and Data System Coronary CT Angiography Score that indicates that no plaque or stenosis is present. Absence of coronary artery disease. 614 C191386 Diagnostic Procedures 1 1%-24% C191504 Coronary Artery Disease Reporting and Data System Coronary CT Angiography Score 1 CAD-RADS CCTA Score 1 A Coronary Artery Disease Reporting and Data System Coronary CT Angiography Score that indicates that minimal stenosis (1-24%) or plaque with no stenosis is present. Minimal non-obstructive coronary artery disease. 615 C191386 Diagnostic Procedures 2 25%-49% C191505 Coronary Artery Disease Reporting and Data System Coronary CT Angiography Score 2 CAD-RADS CCTA Score 2 A Coronary Artery Disease Reporting and Data System Coronary CT Angiography Score that indicates that mild stenosis (25-49%) is present. Mild non-obstructive coronary artery disease. 616 C191386 Diagnostic Procedures 3 50%-69% C191506 Coronary Artery Disease Reporting and Data System Coronary CT Angiography Score 3 CAD-RADS CCTA Score 3 A Coronary Artery Disease Reporting and Data System Coronary CT Angiography Score that indicates that moderate stenosis (50-69%) is present. 617 C191386 Diagnostic Procedures 4 70%-99% or Left main >50% or 3-vessel obstructive disease C191507 Coronary Artery Disease Reporting and Data System Coronary CT Angiography Score 4 CAD-RADS CCTA Score 4 A Coronary Artery Disease Reporting and Data System Coronary CT Angiography Score that indicates that severe stenosis (70-99%) or left main stenosis greater than or equal to 50% or 3-vessel obstructive (greater than or equal to 70%) disease is present. 618 C191386 Diagnostic Procedures 5 100% C191508 Coronary Artery Disease Reporting and Data System Coronary CT Angiography Score 5 CAD-RADS CCTA Score 5 A Coronary Artery Disease Reporting and Data System Coronary CT Angiography Score that indicates that total occlusion or subtotal occlusion is present. 619 C191386 Diagnostic Procedures Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 620 C191386 Diagnostic Procedures Lower extremity ultrasound Documented findings from the ultrasound examination C191543 Lower Extremity Doppler Ultrasonography Doppler Ultrasound of Leg Ultrasound examination of the blood flow through the vasculature of the lower extremities. 621 C191386 Diagnostic Procedures DVT Thrombosis formation within deep veins during acute COVID-19 C49343 Deep Vein Thrombosis A blood clot in a deep vein, predominantly in the lower extremity, but may include the pelvis or upper extremity. 622 C191386 Diagnostic Procedures Arterial thrombosis Formation of a blood clot in the lumen of an artery during acute COVID-19 C98826 Arterial Thrombosis Formation of a blood clot in the lumen of an artery. 623 C191386 Diagnostic Procedures Myocardial perfusion imaging An imaging procedure that quantifies blood flow throughout the heart muscle C102676 Myocardial Perfusion Imaging A procedure that captures pictures of blood flow throughout the heart muscle. 624 C191386 Diagnostic Procedures Coronary angiography Documented findings from coronary angiography C100085 Coronary Angiography The passage of a catheter into the aortic root or other great vessel for the purpose of angiography of the native coronary arteries or bypass grafts supplying native coronary arteries. (ACC) 625 C191386 Diagnostic Procedures Left heart catheterization Documented findings from left heart catheterization C80413 Left Heart Catheterization The passage of a catheter into the left ventricle for the purposes of angiography, measurement of ventricular pressures, and/or oxygen saturation. 626 C191386 Diagnostic Procedures Left ventricular end-diastolic pressure (mm Hg) C120919 Left Ventricular End Diastolic Pressure The pressure within the left ventricle following the completion of diastolic filling, just prior to systole. 627 C191386 Diagnostic Procedures Left ventriculography EF C135374 Calculated Left Ventricular Ejection Fraction The percent or fraction of the left ventricular end diastolic volume ejected in systole, which is calculated as the left ventricular stroke volume divided by the left ventricular end diastolic volume. 628 C191386 Diagnostic Procedures RA mean pressure Mean right atrial pressure measured from pulmonary artery catheter C191460 Mean Right Atrial Pressure The average blood pressure within the right atrium as measured from a pulmonary artery catheter. 629 C191386 Diagnostic Procedures mmHg C49670 Millimeter of Mercury Torr A non-SI unit of pressure equal to 133,332 Pa or 1.316E10-3 standard atmosphere. Use of this unit is generally deprecated by ISO and IUPAC. 630 C191386 Diagnostic Procedures Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 631 C191386 Diagnostic Procedures PA mean pressure Mean blood pressure in the pulmonary artery C120935 Mean Pulmonary Arterial Pressure The average blood pressure reading in the pulmonary artery as calculated through multiple cardiac cycles. 632 C191386 Diagnostic Procedures mmHg C49670 Millimeter of Mercury Torr A non-SI unit of pressure equal to 133,332 Pa or 1.316E10-3 standard atmosphere. Use of this unit is generally deprecated by ISO and IUPAC. 633 C191386 Diagnostic Procedures Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 634 C191386 Diagnostic Procedures PA systolic pressure The blood pressure in the pulmonary artery during the contraction of the left ventricle of the heart C120943 Pulmonary Artery Systolic Pressure The blood pressure in the pulmonary artery during the contraction of the left ventricle of the heart. 635 C191386 Diagnostic Procedures mmHg C49670 Millimeter of Mercury Torr A non-SI unit of pressure equal to 133,332 Pa or 1.316E10-3 standard atmosphere. Use of this unit is generally deprecated by ISO and IUPAC. 636 C191386 Diagnostic Procedures Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 637 C191386 Diagnostic Procedures PA diastolic pressure The blood pressure in the pulmonary artery during ventricular relaxation (diastole) C120941 Pulmonary Artery Diastolic Pressure The blood pressure in the pulmonary artery during ventricular relaxation (diastole). 638 C191386 Diagnostic Procedures mmHg C49670 Millimeter of Mercury Torr A non-SI unit of pressure equal to 133,332 Pa or 1.316E10-3 standard atmosphere. Use of this unit is generally deprecated by ISO and IUPAC. 639 C191386 Diagnostic Procedures Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 640 C191386 Diagnostic Procedures PAPi Pulse pressure across pulmonary artery divided by RA (calculated systolic pulmonary arterial pressure - diastolic pulmonary pressure)/right atrial pressure) C191614 Pulmonary Artery Pulsatility Index PAPi A predictive measure of right ventricular failure after inferior myocardial infarction and left ventricular assist device implantation. It is calculated from the ratio of the pulmonary artery pulse pressure to right atrial pressure (calculated systolic pulmonary arterial pressure - diastolic pulmonary pressure)/right atrial pressure). 641 C191386 Diagnostic Procedures Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 642 C191386 Diagnostic Procedures Mean pulmonary capillary wedge pressure The pressure measured by wedging a pulmonary catheter with an inflated balloon into a small pulmonary arterial branch C129955 Pulmonary Artery Wedge Pressure PAOP || PAWP || PCWP || Pulmonary Arterial Wedge Pressure || Pulmonary Artery Occlusion Pressure || Pulmonary Capillary Wedge Pressure The pressure measured by wedging a pulmonary catheter with an inflated balloon into a small pulmonary arterial branch. 643 C191386 Diagnostic Procedures mmHg C49670 Millimeter of Mercury Torr A non-SI unit of pressure equal to 133,332 Pa or 1.316E10-3 standard atmosphere. Use of this unit is generally deprecated by ISO and IUPAC. 644 C191386 Diagnostic Procedures Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 645 C191386 Diagnostic Procedures Cardiac output The total volume of blood pumped by the heart over a set period of time, conventionally 1 min; it is calculated as heart rate times stroke volume and is additionally dependent on preload and afterload for functional output. C119246 Cardiac Output The total volume of blood pumped by the heart over a set period of time, conventionally one minute; it is calculated as heart rate times stroke volume (CO= HR x SV), and is additionally dependent on preload and afterload for functional output. 646 C191386 Diagnostic Procedures liters/min C67388 Liter per Minute Cubic Decimeter per Minute || Liter/Minute A metric unit of volumetric flow rate defined as the rate at which one liter of matter crosses a given surface during the period of time equal to one minute. 647 C191386 Diagnostic Procedures Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 648 C191386 Diagnostic Procedures Cardiac index The measure of an individual's cardiac output as divided by their body surface area ). This calculation is a useful function to determine an individual's cardiac performance in relation to their body size, providing an overview of global cardiovascular function. C119245 Cardiac Index The measure of an individual's cardiac output as divided by their body surface area (CI= CO/BSA). This calculation is a useful function to determine an individual's cardiac performance in relation to their body size, providing an overview of global cardiovascular function. 649 C191386 Diagnostic Procedures liters/min/m^2 C105496 Liter Per Minute Per Square Meter L/min/m2 || Liters per Minute per Square Meter A unit expressed as one liter of volume per unit of time equal to one minute per square meter of area. (NCI) 650 C191386 Diagnostic Procedures Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 651 C191386 Diagnostic Procedures Transpulmonary gradient Difference between mean pulmonary artery pressure and mean pulmonary capillary wedge pressure C191572 Transpulmonary Gradient The difference between the mean pulmonary artery pressure and the mean pulmonary capillary wedge pressure. 652 C191386 Diagnostic Procedures Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 653 C191386 Diagnostic Procedures Pulmonary vascular resistance Pulmonary vascular resistance is calculated as (mean PA pressure minus mean pulmonary capillary wedge pressure) divided by cardiac output. C119247 Pulmonary Vascular Resistance The resistance to blood flow offered by the pulmonary vasculature, which is normally one sixth of SVR. The major determinant of PVR is pulmonary vessel constriction, most often caused by hypoxia and/or hypercarbia. Prolonged elevated PVR can cause right heart failure. 654 C191386 Diagnostic Procedures Wood units C150900 Hybrid Resistance Units Wood Unit || mmHg*min/L A unit of resistance equal to the number of millimeters of mercury times minutes, per unit of volume equal to one liter. 655 C191386 Diagnostic Procedures Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 656 C191386 Diagnostic Procedures Systemic vascular resistance Systemic vascular resistance is calculated as the systemic mean arterial blood pressure minus right arterial pressure divided by cardiac output. C119248 Systemic Vascular Resistance Total Peripheral Resistance The resistance to blood flow offered by all systemic vasculature, excluding pulmonary vasculature. The major determinant of SVR is arteriolar tone, but blood viscosity and vascular capacitance are also contributing factors. 657 C191386 Diagnostic Procedures Wood units C150900 Hybrid Resistance Units Wood Unit || mmHg*min/L A unit of resistance equal to the number of millimeters of mercury times minutes, per unit of volume equal to one liter. 658 C191386 Diagnostic Procedures Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 659 C191386 Diagnostic Procedures Mixed venous O2 saturation Saturation measured via a sample of blood from a pulmonary artery catheter measures the end result of O2 consumption and delivery, used in the ICU as a measure of O2 extraction by the body. C191583 Mixed Venous Oxygen Saturation SmvO2 The oxygen content of the venous blood returned to the heart via the superior and inferior vena caval system after perfusing the entire body. The venous blood in the pulmonary artery, measured using a pulmonary artery catheter, represents oxygen extraction from the whole body. 660 C191386 Diagnostic Procedures % C25613 Percentage A fraction or ratio with 100 understood as the denominator. 661 C191386 Diagnostic Procedures Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 662 C191386 Diagnostic Procedures Cardiac MRI A noninvasive medical imaging technology using magnetic field and radio waves to evaluate the heart's anatomy and function for detection and monitoring of cardiac diseases. C137915 Magnetic Resonance Imaging of the Heart Cardiac MRI || Heart MRI Magnetic resonance imaging of the heart. 663 C191386 Diagnostic Procedures Myocardial edema by T2 mapping or T2-weighted imaging Regional or global myocardial SI increase in T2-weighted images suggestive of edema C191559 Myocardial Edema by T2 Mapping or T2-weighted Imaging Regional or global myocardial increase in signal intensity on T2-weighted images suggestive of edema. 664 C191386 Diagnostic Procedures Myocardial injury by T1 mapping Regional or global myocardial injury by T1 mapping C191561 Myocardial Injury by T1 mapping Regional or global myocardial injury as suggested by T1-weighted images. 665 C191386 Diagnostic Procedures Myocardial injury by late gadolinium enhancement Increased global myocardial late gadolinium enhancement in gadolinium-enhanced T1-weighted images C191560 Myocardial Injury by Late Gadolinium Enhancement of T1 Imaging Global myocardial increase in signal intensity on gadolinium-enhanced T1-weighted images suggestive of myocardial injury. 666 C191386 Diagnostic Procedures Myocarditis Acute viral myocarditis, usually lasting 1-3 d, is characterized by cardiomyocyte necrosis directly triggered by the viral infection. Humoral and cellular immunologic responses in the myocardium may persist for months and may result in a chronic postinfectious autoimmune myocarditis. C128381 Viral Myocarditis Myocarditis that is caused by an infection with a viral agent. 667 C191386 Diagnostic Procedures Pericardial changes Pericardial effusion, thickening, increased signal intensity on late gadolinium enhancement C191562 Pericardial Changes on Imaging Pericardial effusion or thickening as suggested by increased signal intensity or late gadolinium enhancement. 668 C191386 Diagnostic Procedures Ventricular functional abnormalities LV systolic or diastolic dysfunction, RV systolic or diastolic dysfunction, functional valvular regurgitation C111655 Ventricular Dysfunction Impairment of the ventricle to either fill or eject adequately. 669 C191386 Diagnostic Procedures Other cardiac structural abnormalities LV, RV, LA, RA chamber enlargement, wall motion abnormalities, valvular structural abnormalities, cardiac masses C99538 Structural Heart Abnormality An anatomic deformity of the heart, ventricles or great vessels. 670 C191386 Diagnostic Procedures FDG-PET Documented findings from FDG-PET C103400 FDG-Positron Emission Tomography FDG-PET An imaging technique that utilizes positron emission tomography to produce a three-dimensional image of functional processes in the body. The system detects pairs of gamma rays emitted indirectly by a positron-emitting radionuclide (tracer), which is introduced into the body on the biologically active molecule (fludeoxyglucose) FDG. FDG is an analogue of glucose which when imaged will give tissue metabolic activity, in terms of regional glucose uptake. 671 C191386 Diagnostic Procedures Myocarditis C34831 Myocarditis Inflammation of the muscle tissue of the heart. 672 C191386 Diagnostic Procedures Pericarditis C34915 Pericarditis An inflammatory process affecting the pericardium. 673 C191386 Diagnostic Procedures Other A proper value is applicable but not known. C17649 Other Other or Miscellaneous Different than the one(s) previously specified or mentioned. 674 C191386 Diagnostic Procedures Brain CT without contrast Documented findings from brain CT without contrast C137897 Computed Tomography of the Brain without Contrast Brain CT without Contrast || Head CT without Contrast Computed tomography of the brain without the use of a contrast agent. 675 C191386 Diagnostic Procedures Hemorrhagic stroke Brain tissue necrosis due to an intracerebral bleed C95803 Hemorrhagic Stroke Hemorrhagic Cerebrovascular Accident An acute episode of focal or global cerebral or spinal dysfunction caused by intraparenchymal, intraventricular, or subarachnoid hemorrhage. 676 C191386 Diagnostic Procedures Acute ischemic stroke || Ischemic stroke Acute onset of neurological deficits resulting from a loss of blood supply to brain tissue in an area of arterial distribution. C95802 Ischemic Stroke Ischemic Cerebrovascular Accident An acute episode of focal cerebral, spinal, or retinal dysfunction caused by infarction of brain tissue. 677 C191386 Diagnostic Procedures Hypoxic ischemic encephalopathy Injury to the central nervous system that occurs when there is insufficient delivery of oxygen to all or part of the brain C35549 Hypoxic Ischemic Encephalopathy Anoxic encephalopathy Ischemic brain damage in which the entire brain is deprived of oxygen. It may be fatal or lead to long term disabilities including developmental delays, intellectual disability, and seizures. 678 C191386 Diagnostic Procedures Brain MRI Documented findings from brain MRI C137913 Magnetic Resonance Imaging of the Brain with and without Contrast Brain MRI with and without Contrast || Brain Magnetic Resonance Imaging with and without Contrast || Head MRI with and without Contrast Magnetic resonance imaging of the brain with and without the use of a contrast agent to enhance the image. 679 C191386 Diagnostic Procedures Hemorrhagic stroke Brain tissue necrosis due to an intracerebral bleed C95803 Hemorrhagic Stroke Hemorrhagic Cerebrovascular Accident An acute episode of focal or global cerebral or spinal dysfunction caused by intraparenchymal, intraventricular, or subarachnoid hemorrhage. 680 C191386 Diagnostic Procedures Acute ischemic stroke || Ischemic stroke Acute onset of neurological deficits resulting from a loss of blood supply to brain tissue in an area of arterial distribution. C95802 Ischemic Stroke Ischemic Cerebrovascular Accident An acute episode of focal cerebral, spinal, or retinal dysfunction caused by infarction of brain tissue. 681 C191386 Diagnostic Procedures Hypoxic ischemic encephalopathy Injury to the central nervous system that occurs when there is insufficient delivery of oxygen to all or part of the brain C35549 Hypoxic Ischemic Encephalopathy Anoxic encephalopathy Ischemic brain damage in which the entire brain is deprived of oxygen. It may be fatal or lead to long term disabilities including developmental delays, intellectual disability, and seizures. 682 C191387 Pharmacological Therapy Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) C191470 Preexisting Cardiovascular Disease Therapy Current or previous treatment received for cardiovascular disease that was present prior to the current presentation. 683 C191387 Pharmacological Therapy Aldosterone inhibitor (mineralocorticoid receptor antagonist) C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) Spironolactone or eplerenone, which antagonize the action of aldosterone at mineralocorticoid receptors C101255 Aldosterone Receptor Antagonist Antimineralocorticoid A class of agents that act by selectively inhibiting aldosterone receptor activation with diuretic activity. Aldosterone receptor antagonists bind to and block the activation of aldosterone (mineralocorticoid) receptors on the epithelial cells in the late distal tubule and collecting duct of the kidney, thus preventing the synthesis of aldosterone-induced proteins which enhance Na+ retention and K+ and H+ secretion. The enhanced excretion of Na+ produces diuresis ultimately resulting in a reduction in blood pressure without the loss of K+. 684 C191387 Pharmacological Therapy Yes C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 685 C191387 Pharmacological Therapy No C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) C49487 No The non-affirmative response to a question. 686 C191387 Pharmacological Therapy Unknown C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 687 C191387 Pharmacological Therapy Angiotensin-converting enzyme (ACE) inhibitor medication C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) A medication that inhibits ACE, an enzyme that catalyzes the conversion of angiotensin I to angiotensin II. Inhibition of ACE results in a reduction in angiotensin II and angiotensin II-induced aldosterone secretion, causing vasodilation and natriuresis. C247 ACE Inhibitor Angiotensin-Converting Enzyme Inhibitor Any substance that inhibits angiotensin-converting enzyme (ACE), an enzyme that catalyzes the conversion of angiotensin I to angiotensin II. Inhibition of ACE results in a reduction in angiotensin II and angiotensin II-induced aldosterone secretion, causing vasodilation and natriuresis. 688 C191387 Pharmacological Therapy Yes C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 689 C191387 Pharmacological Therapy No C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) C49487 No The non-affirmative response to a question. 690 C191387 Pharmacological Therapy Unknown C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 691 C191387 Pharmacological Therapy Angiotensin II receptor blocker (ARB) medication C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) An angiotensin receptor blocker (ARB) medication, a class of agents that act by selectively inhibiting angiotensin II receptor activation in the renin-angiotensin-aldosterone system. Angiotensin II receptor antagonists bind to and block the activation of angiotensin II type 1 (AT1) receptors, thereby reducing production and secretion of aldosterone, among other actions. The combined effects result in reduction of blood pressure. It is primarily used for the treatment of hypertension or HF. C66930 Angiotensin II Receptor Antagonist Angiotensin II Receptor Antagonists || Angiotensin II Receptor Blocker || Angiotensin Receptor Blockers A class of agents that act by selectively inhibiting angiotensin II receptor activation in the renin-angiotensin-aldosterone system. Angiotensin II receptor antagonists bind to and block the activation of angiotensin II type 1 (AT1) receptors, thereby reducing production and secretion of aldosterone, amongst other actions. The combined effects result in reduction of blood pressure. Although this class of agents is also used in diabetic nephropathy (kidney damage due to diabetes) and congestive heart failure, it is primarily used for the treatment of hypertension in cases where the patient is intolerant of ACE inhibitor therapy. 692 C191387 Pharmacological Therapy Yes C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 693 C191387 Pharmacological Therapy No C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) C49487 No The non-affirmative response to a question. 694 C191387 Pharmacological Therapy Unknown C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 695 C191387 Pharmacological Therapy ARNi C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) Combination of an angiotensin receptor blocker (above) and a neprilysin inhibitor (e.g., sacubitril). Additionally, inhibits neprilysin, a neutral endopeptidase that degrades vasoactive peptides, such as bradykinin, and natriuretic peptides. C190796 Angiotensin Receptor-Neprilysin Inhibitor A combination agent containing an angiotensin receptor blocker and a neprilysin inhibitor. 696 C191387 Pharmacological Therapy Yes C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 697 C191387 Pharmacological Therapy No C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) C49487 No The non-affirmative response to a question. 698 C191387 Pharmacological Therapy Unknown C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 699 C191387 Pharmacological Therapy Beta-adrenergic antagonist (beta blocker) medication C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) A beta-adrenergic receptor antagonist (beta blocker) medication. Includes bisoprolol, carvedilol, metoprolol succinate, metoprolol tartrate, atenolol. C29576 Beta-Adrenergic Antagonist Beta Blocker || Beta-Adrenergic Blocking Agent || Beta-Blockers Natural or synthetic beta adrenergic antagonists selectively or non-selectively blocking or diminishing physiologic beta-adrenergic agonist actions on the sympathetic system. This group of antagonists are generally used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety. 700 C191387 Pharmacological Therapy Yes C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 701 C191387 Pharmacological Therapy No C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) C49487 No The non-affirmative response to a question. 702 C191387 Pharmacological Therapy Unknown C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 703 C191387 Pharmacological Therapy Metformin C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) A specific agent belonging to the biguanide class of antihyperglycemic agents C61612 Metformin N,N-dimethylbiguanide An agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity. Metformin is associated with a very low incidence of lactic acidosis. This agent helps reduce LDL cholesterol and triglyceride levels, and is not associated with weight gain, and prevents the cardiovascular complications of diabetes. Metformin is not metabolized and is excreted unchanged by the kidneys. 704 C191387 Pharmacological Therapy Yes C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 705 C191387 Pharmacological Therapy No C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) C49487 No The non-affirmative response to a question. 706 C191387 Pharmacological Therapy Unknown C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 707 C191387 Pharmacological Therapy SGLT2 inhibitor C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) SGLT2 inhibitors inhibit the sodium glucose cotransporter 2 in the kidney, and selected agents in this class have demonstrated benefit in HF, CKD, ASCVD, and diabetes. C98083 SGLT2 Inhibitor SLC5A2 Inhibitor Any inhibitor of the sodium-glucose co-transporter subtype 2 (SGLT2) with antihyperglycemic activity. By binding to and blocking SGLT2, these inhibitors suppress reabsorption of glucose in the proximal tubule within the kidneys and thereby enhancing urinary excretion of glucose. This eventually normalizes blood glucose levels. SGLT2, a transport system exclusively expressed in the proximal renal tubules, mediates about 90% of renal glucose reabsorption from tubular fluid. 708 C191387 Pharmacological Therapy Yes C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 709 C191387 Pharmacological Therapy No C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) C49487 No The non-affirmative response to a question. 710 C191387 Pharmacological Therapy Unknown C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 711 C191387 Pharmacological Therapy GLP-1 receptor agonist C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) Select medications in this class have been shown to improve ASCVD outcomes, drive weight loss, and lower glucose. C98085 GLP-1 Mimetics GLP-1 Analogue || GLP-1 Receptor Agonist Any of the analogues of the endogenous gastrointestinal hormone glucagon-like peptide-1 (GLP-1) with antihyperglycemic activity. GLP-1 mimetics mimic the activity of GLP-1 and thereby stimulate glucose-dependent secretion of insulin from pancreatic beta cells, suppress glucagon secretion from alpha cells, increase insulin sensitivity and inhibit gastric emptying thereby slowing absorption of nutrients and creating a satiating effect. Altogether, this lowers blood glucose levels. GLP-1 is rapidly inactivated by the enzyme dipeptidyl peptidase-4 (DPP-4). 712 C191387 Pharmacological Therapy Yes C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 713 C191387 Pharmacological Therapy No C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) C49487 No The non-affirmative response to a question. 714 C191387 Pharmacological Therapy Unknown C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 715 C191387 Pharmacological Therapy Statin C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) An HMG-CoA reductase inhibitor ("statin"). Lipid-lowering medications with proven ASCVD benefits. C1655 HMG-CoA Reductase Inhibitor Hydroxymethylglutaryl CoenzymeA Reductase Inhibitors || Statin Any substance that inhibits HMG-CoA reductase, a key enzyme in cholesterol synthesis. Inhibition of HMG-CoA reductase acts to lower plasma cholesterol and lipoprotein levels. 716 C191387 Pharmacological Therapy Yes C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 717 C191387 Pharmacological Therapy No C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) C49487 No The non-affirmative response to a question. 718 C191387 Pharmacological Therapy Unknown C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 719 C191387 Pharmacological Therapy Ezetimibe C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) A cholesterol absorption inhibitor with lipid-lowering activity C47529 Ezetimibe Ezedoc An azetidinone derivative and a cholesterol absorption inhibitor with lipid-lowering activity. Ezetimibe appears to interact physically with cholesterol transporters at the brush border of the small intestine and inhibits the intestinal absorption of cholesterol and related phytosterols. As a result, ezetimibe causes a decrease in the level of blood cholesterol or an increase in the clearance of cholesterol from the bloodstream. Overall, the following effects observed are a reduction of hepatic cholesterol stores and a reduction of total cholesterol, LDL cholesterol, and other triglycerides in the blood. 720 C191387 Pharmacological Therapy Yes C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 721 C191387 Pharmacological Therapy No C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) C49487 No The non-affirmative response to a question. 722 C191387 Pharmacological Therapy Unknown C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 723 C191387 Pharmacological Therapy PCSK9 inhibitor C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) Inhibits an enzyme (PCSK9), resulting in a reduction in circulating LDL cholesterol C190797 PCSK9 Inhibitor Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor Any agent that inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9). 724 C191387 Pharmacological Therapy Yes C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 725 C191387 Pharmacological Therapy No C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) C49487 No The non-affirmative response to a question. 726 C191387 Pharmacological Therapy Unknown C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 727 C191387 Pharmacological Therapy Bempedoic acid C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) Bempedoic acid decreases LDL cholesterol by inhibiting ATP-citrate lyase. C166494 Bempedoic Acid An orally bioavailable prodrug and inhibitor of adenosine triphosphate-citrate lyase (ACL), with anti-hyperlipidemic activity. Upon oral administration, bempedoic acid becomes activated to its thioester form with coenzyme A (CoA) by the enzyme very long-chain acyl-CoA synthetase 1 (ACSVL1; SLC27A2) in the liver. The activated form inhibits ACL, thereby preventing the liver's biosynthesis of cholesterol. This lowers low-density lipoprotein cholesterol (LDL-C) levels. ACL is an enzyme upstream of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase in the cholesterol biosynthesis pathway. 728 C191387 Pharmacological Therapy Yes C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 729 C191387 Pharmacological Therapy No C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) C49487 No The non-affirmative response to a question. 730 C191387 Pharmacological Therapy Unknown C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 731 C191387 Pharmacological Therapy Aspirin C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) Acetylsalicylic acid decreases synthesis of prostaglandin, platelet aggregation, and inflammation. This agent exhibits analgesic, antipyretic, and anticoagulant properties. C287 Aspirin Acetylsalicylic Acid An orally administered non-steroidal antiinflammatory agent. Acetylsalicylic acid binds to and acetylates serine residues in cyclooxygenases, resulting in decreased synthesis of prostaglandin, platelet aggregation, and inflammation. This agent exhibits analgesic, antipyretic, and anticoagulant properties. 732 C191387 Pharmacological Therapy Yes C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 733 C191387 Pharmacological Therapy No C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) C49487 No The non-affirmative response to a question. 734 C191387 Pharmacological Therapy Unknown C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 735 C191387 Pharmacological Therapy P2Y12 inhibitor C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) A nonaspirin P2Y12 inhibitor such as clopidogrel, ticagrelor, prasugrel as an antiplatelet agent C190801 P2Y12 Inhibitor P2Y12 Receptor Blocker || Platelet P2Y12 Receptor Antagonist Any agent that inhibits the adenosine diphosphate (ADP) receptor P2Y12. 736 C191387 Pharmacological Therapy Yes C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 737 C191387 Pharmacological Therapy No C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) C49487 No The non-affirmative response to a question. 738 C191387 Pharmacological Therapy Unknown C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 739 C191387 Pharmacological Therapy Warfarin C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) A vitamin K antagonist anticoagulant C945 Warfarin A synthetic anticoagulant. Warfarin inhibits the regeneration of vitamin K1 epoxide and so the synthesis of vitamin K dependent clotting factors, which include Factors II, VII, IX and X, and the anticoagulant proteins C and S. This inhibition results in a sequential depression of Factors VII, IX, X and II activities. Vitamin K is an essential cofactor for the post ribosomal synthesis of the vitamin K dependent clotting factors. The vitamin promotes the biosynthesis of gamma-carboxyglutamic acid residues in these proteins which are essential for biological activity. 740 C191387 Pharmacological Therapy Yes C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 741 C191387 Pharmacological Therapy No C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) C49487 No The non-affirmative response to a question. 742 C191387 Pharmacological Therapy Unknown C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 743 C191387 Pharmacological Therapy DOAC C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) Oral anticoagulant that directly inhibits specific proteins within the coagulation cascade (rivaroxaban, apixaban, dabigatran, or edoxaban) C180619 Direct Oral Anticoagulant DOAC || DOACs || Direct Oral Anticoagulants || NOAC || Novel Oral Anticoagulant An agent taken orally to prevent blood clot formation by directly inhibiting certain coagulation factors including thrombin (factor IIa) or factor Xa. 744 C191387 Pharmacological Therapy Yes C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 745 C191387 Pharmacological Therapy No C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) C49487 No The non-affirmative response to a question. 746 C191387 Pharmacological Therapy Unknown C191405 Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 747 C191387 Pharmacological Therapy SARS-CoV-2 antiviral agents C191404 Therapies for COVID-19 A prodrug of an ATP analog, with potential antiviral activity against a variety of RNA viruses. Competes with ATP for incorporation into RNA and inhibits the action of viral RNA-dependent RNA polymerase. C190794 SARS-CoV-2 Antiviral Agent Any agent that inhibits the SARS-CoV-2 virus by directly interfering with viral replication and/or life cycle. 748 C191387 Pharmacological Therapy SARS-CoV-2 antiviral agents: remdesivir C191404 Therapies for COVID-19 C152185 Remdesivir 2-Ethylbutyl (2S)-2-(((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate || L-Alanine, N-((S)-hydroxyphenoxyphosphinyl)-, 2-Ethylbutyl Ester, 6-Ester with 2-C-(4-aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-2,5-anhydro-D-altrononitrile A prodrug of an adenosine triphosphate (ATP) analog, with potential antiviral activity against a variety of RNA viruses. Upon administration, remdesivir, being a prodrug, is metabolized into its active form GS-441524. As an ATP analog, GS-441524 competes with ATP for incorporation into RNA and inhibits the action of viral RNA-dependent RNA polymerase. This results in the termination of RNA transcription and decreases viral RNA production. 749 C191387 Pharmacological Therapy Yes C191404 Therapies for COVID-19 ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 750 C191387 Pharmacological Therapy No C191404 Therapies for COVID-19 C49487 No The non-affirmative response to a question. 751 C191387 Pharmacological Therapy Unknown C191404 Therapies for COVID-19 A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 752 C191387 Pharmacological Therapy SARS-CoV-2 antiviral agents: molnupiravir C191404 Therapies for COVID-19 C172633 Molnupiravir N4-Hydroxycytidine, 5'-Isopropyl Ester || Uridine, 4-Oxime, 5'-(2-Methylpropanoate) An orally bioavailable prodrug of EIDD-1931, the synthetic ribonucleoside derivative N4-hydroxycytidine and ribonucleoside analog, with potential antiviral activity against a variety of RNA viruses. Upon oral administration, molnupiravir, being a prodrug, is metabolized into its active form EIDD-1931 and converted into its triphosphate (TP) form. The TP form of EIDD-1931 is incorporated into RNA and inhibits the action of viral RNA-dependent RNA polymerase. This results in the termination of RNA transcription and decreases viral RNA production, and viral RNA replication. 753 C191387 Pharmacological Therapy Yes C191404 Therapies for COVID-19 ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 754 C191387 Pharmacological Therapy No C191404 Therapies for COVID-19 C49487 No The non-affirmative response to a question. 755 C191387 Pharmacological Therapy Unknown C191404 Therapies for COVID-19 A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 756 C191387 Pharmacological Therapy SARS-CoV-2 protease inhibitors: nirmatrelvir/ritonavir C191404 Therapies for COVID-19 Nirmatrelvir inhibits the SARS-CoV-2 main protease (Mpro), which results in inhibition of viral replication. Ritonavir has no direct activity against SARS-CoV-2 but is a pharmacokinetic boosting agent that results in higher plasma concentrations of nirmatrelvir. C188303 Nirmatrelvir/Ritonavir Ritonavir/Nirmatrelvir A fixed combination of nirmatrelvir, an inhibitor of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) main protease (Mpro; 3C-like protease; 3CL protease; 3CLpro; nsp5 protease), and ritonavir, an inhibitor of cytochrome P450 3A4 (CYP3A4), that may be used to treat coronavirus disease 2019 (COVID-19). Upon oral administration of nirmatrelvir/ritonavir, nirmatrelvir selectively targets, binds to, and inhibits the activity of SARS-CoV-2 Mpro. This inhibits the proteolytic cleavage of viral polyproteins, thereby inhibiting the formation of viral proteins including helicase, single-stranded-RNA-binding protein, RNA-dependent RNA polymerase, 20-O-ribose methyltransferase, endoribonuclease and exoribonuclease. This prevents viral transcription and replication. Ritonavir inhibits CYP3A4-mediated metabolism of nirmatrelvir, thereby increasing the plasma concentration of nirmatrelvir. 757 C191387 Pharmacological Therapy Yes C191404 Therapies for COVID-19 ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 758 C191387 Pharmacological Therapy No C191404 Therapies for COVID-19 C49487 No The non-affirmative response to a question. 759 C191387 Pharmacological Therapy Unknown C191404 Therapies for COVID-19 A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 760 C191387 Pharmacological Therapy Corticosteroids C191404 Therapies for COVID-19 Hormones synthesized in the cortex of the adrenal gland and consisting of 2 subclasses, glucocorticoids (carbohydrate regulation) and mineralocorticoids (electrolyte regulation) C211 Therapeutic Corticosteroid Corticosteroids 761 C191387 Pharmacological Therapy Yes C191404 Therapies for COVID-19 ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 762 C191387 Pharmacological Therapy No C191404 Therapies for COVID-19 C49487 No The non-affirmative response to a question. 763 C191387 Pharmacological Therapy Unknown C191404 Therapies for COVID-19 A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 764 C191387 Pharmacological Therapy IL-6 receptor monoclonal antibodies C191404 Therapies for COVID-19 An antibody that recognizes and binds the IL-6 receptor C190830 Anti-IL-6R Monoclonal Antibody Anti-IL-6 Receptor Monoclonal Antibody || IL-6 Receptor Monoclonal Antibody Any monoclonal antibody that is directed against interleukin-6 receptor (IL-6R). 765 C191387 Pharmacological Therapy IL-6 receptor monoclonal antibodies: tocilizumab C191404 Therapies for COVID-19 C84217 Tocilizumab Immunoglobulin G1, Anti-(Human Interleukin 6 Receptor) (Human-Mouse Monoclonal MRA Heavy Chain), Disulfide with Human-Mouse Monoclonal MRA Kappa-Chain, Dimer A recombinant, humanized IgG1 monoclonal antibody directed against the interleukin-6 receptor (IL-6R) with immunosuppressant activity. Tocilizumab targets and binds to both the soluble form of IL-6R (sIL-6R) and the membrane-bound form (mIL-6R), thereby blocking the binding of IL-6 to its receptor. This prevents IL-6-mediated signaling. IL-6, a pro-inflammatory cytokine that plays an important role in the regulation of the immune response, is overproduced in autoimmune disorders, certain types of cancers and possibly various other inflammatory conditions. 766 C191387 Pharmacological Therapy Yes C191404 Therapies for COVID-19 ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 767 C191387 Pharmacological Therapy No C191404 Therapies for COVID-19 C49487 No The non-affirmative response to a question. 768 C191387 Pharmacological Therapy Unknown C191404 Therapies for COVID-19 A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 769 C191387 Pharmacological Therapy IL-6 receptor monoclonal antibodies: sarilumab C191404 Therapies for COVID-19 C152302 Sarilumab Immunoglobulin G1, Anti-Human Interleukin 6 Receptor alpha) (Human REGN88 Heavy Chain), Disulfide with Human REGN88 Light Chain, Dimer A recombinant, human immunoglobulin (IgG) monoclonal antibody targeting the interleukin 6 receptor (IL-6R), with potential anti-inflammatory activity. Upon intravenous administration of sarilumab, this agent targets and binds to both soluble IL-6 receptor (sIL-6R) and membrane-bound IL-6 receptor (mIL-6R). This inhibits the binding of the pro-in?ammatory cytokine IL-6 to the IL-6 receptor (IL-6R), which results in the blockade of the IL-6/IL-6R-mediated signal transduction pathway. This may inhibit IL-6/IL-6R-mediated inflammation. 770 C191387 Pharmacological Therapy Yes C191404 Therapies for COVID-19 ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 771 C191387 Pharmacological Therapy No C191404 Therapies for COVID-19 C49487 No The non-affirmative response to a question. 772 C191387 Pharmacological Therapy Unknown C191404 Therapies for COVID-19 A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 773 C191387 Pharmacological Therapy COVID-19 convalescent plasma C191404 Therapies for COVID-19 Plasma that has been collected from patients who have recovered from the novel coronavirus disease, COVID-19. This plasma contains antibodies developed against the SARS-CoV-2 virus and is being investigated for the treatment of COVID-19. C171633 COVID-19 Convalescent Plasma COVID-19 Plasma Plasma that has been collected from patients who have recovered from the novel coronavirus disease, COVID-19. This plasma contains antibodies developed against the SARS-CoV-2 virus and is being investigated for the treatment of COVID-19. 774 C191387 Pharmacological Therapy Yes C191404 Therapies for COVID-19 ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 775 C191387 Pharmacological Therapy No C191404 Therapies for COVID-19 C49487 No The non-affirmative response to a question. 776 C191387 Pharmacological Therapy Unknown C191404 Therapies for COVID-19 A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 777 C191387 Pharmacological Therapy JAK inhibitors C191404 Therapies for COVID-19 A substance that inhibits the biological action of tyrosine-protein kinase JAK1, an enzyme that plays a key role in certain types of cancer and cytokine signaling C172200 JAK Inhibitor Janus Kinase Inhibitor Any agent that targets, binds to and inhibits the activity of one or more of the Janus kinase family of enzymes. 778 C191387 Pharmacological Therapy JAK inhibitors: baricitinib C191404 Therapies for COVID-19 C127012 Baricitinib An orally bioavailable inhibitor of Janus kinases 1 and 2 (JAK1/2), with potential anti-inflammatory, immunomodulating and antineoplastic activities. Upon administration, baricitinib binds to JAK1/2, which inhibits JAK1/2 activation and leads to the inhibition of the JAK-signal transducers and activators of transcription (STAT) signaling pathway. This decreases the production of inflammatory cytokines and may prevent an inflammatory response. In addition, baricitinib may induce apoptosis and reduce proliferation of JAK1/2-expressing tumor cells. JAK kinases are intracellular enzymes involved in cytokine signaling, inflammation, immune function and hematopoiesis; they are also upregulated and/or mutated in various tumor cell types. 779 C191387 Pharmacological Therapy Yes C191404 Therapies for COVID-19 ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 780 C191387 Pharmacological Therapy No C191404 Therapies for COVID-19 C49487 No The non-affirmative response to a question. 781 C191387 Pharmacological Therapy Unknown C191404 Therapies for COVID-19 A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 782 C191387 Pharmacological Therapy JAK inhibitors: tofacitinib C191404 Therapies for COVID-19 C95800 Tofacitinib An orally available inhibitor of Janus kinases (JAK), with immunomodulatory and anti-inflammatory activities. Upon administration, tofacitinib binds to JAK and prevents the activation of the JAK-signal transducers and activators of transcription (STAT) signaling pathway. This may decrease the production of pro-inflammatory cytokines, such as interleukin (IL)-6, -7, -15, -21, interferon-alpha and -beta, and may prevent both an inflammatory response and the inflammation-induced damage caused by certain immunological diseases. JAK kinases are intracellular enzymes involved in signaling pathways affecting hematopoiesis, immunity and inflammation. 783 C191387 Pharmacological Therapy Yes C191404 Therapies for COVID-19 ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 784 C191387 Pharmacological Therapy No C191404 Therapies for COVID-19 C49487 No The non-affirmative response to a question. 785 C191387 Pharmacological Therapy Unknown C191404 Therapies for COVID-19 A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 786 C191387 Pharmacological Therapy Monoclonal antibodies against SARS-CoV-2 C191404 Therapies for COVID-19 Any monoclonal antibody that is directed against the spike (S) protein of SARS-CoV-2 C173741 Anti-spike Protein SARS-CoV-2 Monoclonal Antibody Anti-SARS-CoV-2 Coronavirus Spike Protein Monoclonal Antibody || Anti-SARS-CoV-2 S Protein Monoclonal Antibody || Anti-SARS-CoV-2 Spike Protein Monoclonal Antibody Any monoclonal antibody that is directed against the spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). 787 C191387 Pharmacological Therapy Monoclonal antibodies against SARS-CoV-2: bamlanivimab C191404 Therapies for COVID-19 C173742 Bamlanivimab A neutralizing immunoglobulin G1 (IgG1) monoclonal antibody directed against the spike protein (SP) of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), that can potentially be used for immunization against COVID-19. Upon administration of bamlanivimab, this agent specifically targets and binds to the SP, thereby blocking viral attachment and entry into human cells and may thereby neutralize SARS-CoV-2. This may slow the progression of the disease and accelerate recovery, and may potentially provide temporary protection against infection with SARS-CoV-2. 788 C191387 Pharmacological Therapy Yes C191404 Therapies for COVID-19 ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 789 C191387 Pharmacological Therapy No C191404 Therapies for COVID-19 C49487 No The non-affirmative response to a question. 790 C191387 Pharmacological Therapy Unknown C191404 Therapies for COVID-19 A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 791 C191387 Pharmacological Therapy Monoclonal antibodies against SARS-CoV-2: etesevimab C191404 Therapies for COVID-19 C173977 Etesevimab Anti-COVID-19 Monoclonal Antibody JS016 || Anti-COVID-19 Spike Protein Monoclonal Antibody JS016 || Anti-SARS-CoV-2 Monoclonal Antibody JS016 An Fc-modified neutralizing, recombinant, human monoclonal antibody directed against the spike (S) protein receptor binding domain (RBD) of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), that can potentially be used for immunization against Coronavirus disease 2019 (COVID-19). Upon administration of etesevimab, this agent specifically targets and binds to the RBD of the SARS-CoV-2 S protein. This blocks viral attachment and entry into human host cells and may thereby neutralize SARS-CoV-2. This may slow the progression of the disease and accelerate recovery, and may also provide temporary protection against infection with SARS-CoV-2. S-protein, usually found on the surface of SARS-CoV-2, plays an essential role in the infection pathway of the SARS-CoV-2 virus. 792 C191387 Pharmacological Therapy Yes C191404 Therapies for COVID-19 ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 793 C191387 Pharmacological Therapy No C191404 Therapies for COVID-19 C49487 No The non-affirmative response to a question. 794 C191387 Pharmacological Therapy Unknown C191404 Therapies for COVID-19 A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 795 C191387 Pharmacological Therapy Monoclonal antibodies against SARS-CoV-2: casirivimab/imdevimab C191404 Therapies for COVID-19 C173743 Casirivimab/Imdevimab Anti-COVID Cocktail REGN-COV2 || Anti-Spike SARS-CoV-2 Monoclonal Antibodies REGN-COV2 || Casirivimab Plus Imdevimab || Casirivimab and Imdevimab || Casirivimab+Imdevimab || REGN10933 Plus REGN10987 || REGN10933+REGN10987 || REGN10933/REGN10987 || SARS-CoV-2-specific Antibodies REGN10933 and REGN10987 A combination of two monoclonal antibodies, casirivimab and imdevimab, directed against the spike protein (SP) of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), that can potentially be used for immunization against COVID-19. Upon administration, casirivimab and imdevimab specifically target and bind to non-overlapping regions of the receptor-binding domain (RBD) of SP, thereby blocking viral attachment and entry into human cells and may thereby neutralize SARS-CoV-2. This may slow the progression of the disease and accelerate recovery, and may potentially provide temporary protection against infection with SARS-CoV-2. Binding to two distinct regions of the RBD of SP may decrease the potential for virus escape mutants that occur upon treatment with a single SARS-CoV-2 antibody, and may provide enhanced protection against loss of efficacy. 796 C191387 Pharmacological Therapy Yes C191404 Therapies for COVID-19 ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 797 C191387 Pharmacological Therapy No C191404 Therapies for COVID-19 C49487 No The non-affirmative response to a question. 798 C191387 Pharmacological Therapy Unknown C191404 Therapies for COVID-19 A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 799 C191387 Pharmacological Therapy Monoclonal antibodies against SARS-CoV-2: sotrovimab C191404 Therapies for COVID-19 C177059 Sotrovimab Anti-SARS-CoV-2 Spike Protein Monoclonal Antibody VIR-7831 A neutralizing human monoclonal antibody directed against the spike (S) protein of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), that can potentially be used for passive immunization against Coronavirus disease 2019 (COVID-19). Upon administration, sotrovimab specifically targets and binds to an epitope on the SARS-CoV-2 S protein that is shared with SARS-CoV-1, thereby blocking viral attachment and entry into human cells and may thereby neutralize SARS-CoV-2. This may slow the progression of the disease and accelerate recovery, and may potentially provide temporary protection against infection with SARS-CoV-2. S protein, usually found on the surface of SARS-CoV-2, plays an essential role in the infection pathway of the SARS-CoV-2 virus. 800 C191387 Pharmacological Therapy Yes C191404 Therapies for COVID-19 ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 801 C191387 Pharmacological Therapy No C191404 Therapies for COVID-19 C49487 No The non-affirmative response to a question. 802 C191387 Pharmacological Therapy Unknown C191404 Therapies for COVID-19 A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 803 C191387 Pharmacological Therapy Monoclonal antibodies against SARS-CoV-2: tixagevimab/cilgavimab C191404 Therapies for COVID-19 C175229 Cilgavimab/Tixagevimab AZD8895 + AZD1061 || AZD8895/AZD1061 || Anti-SARS-CoV-2 Spike Protein Monoclonal Antibody AZD7442 || Monoclonal Antibody AZD7442 A combination of two neutralizing human monoclonal antibodies cilgavimab and tixagevimab, that are isolated from convalescent patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, and directed against the spike (S) protein, that can potentially be used for passive immunization against Coronavirus disease 2019 (COVID-19). Upon administration of cilgavimab/tixagevimab, both antibodies specifically target and bind to the SARS-CoV-2 S protein, thereby blocking viral attachment and entry into human cells and may thereby neutralize SARS-CoV-2. This may slow the progression of the disease and accelerate recovery, and may potentially provide temporary protection against infection with SARS-CoV-2. S protein, usually found on the surface of SARS-CoV-2, plays an essential role in the infection pathway of the SARS-CoV-2 virus. 804 C191387 Pharmacological Therapy Yes C191404 Therapies for COVID-19 ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 805 C191387 Pharmacological Therapy No C191404 Therapies for COVID-19 C49487 No The non-affirmative response to a question. 806 C191387 Pharmacological Therapy Unknown C191404 Therapies for COVID-19 A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 807 C191387 Pharmacological Therapy Monoclonal antibodies against SARS-CoV-2: bebtelovimab C191404 Therapies for COVID-19 C182122 Bebtelovimab A neutralizing human immunoglobulin G1 (IgG1) monoclonal antibody, isolated from a patient who has recovered from the Coronavirus disease 2019 (COVID-19), directed against the spike (S) protein of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), that can potentially be used for immunization against COVID-19. Upon administration, bebtelovimab specifically targets and binds to the receptor-binding domain (RBD) of SARS-CoV-2 S protein, thereby blocking viral attachment and entry into human cells and may thereby neutralize SARS-CoV-2. This may slow the progression of the disease and accelerate recovery, and may potentially provide temporary protection against infection with SARS-CoV-2. S protein, usually found on the surface of SARS-CoV-2, plays an essential role in the infection pathway of the SARS-CoV-2 virus. 808 C191387 Pharmacological Therapy Yes C191404 Therapies for COVID-19 ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 809 C191387 Pharmacological Therapy No C191404 Therapies for COVID-19 C49487 No The non-affirmative response to a question. 810 C191387 Pharmacological Therapy Unknown C191404 Therapies for COVID-19 A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 811 C191387 Pharmacological Therapy SARS-CoV-2 vaccine C191404 Therapies for COVID-19 Any vaccine that decreases the risk of acquiring SARS-CoV-2 infection and development of acute COVID-19 C173023 COVID-19 Vaccine SARS-CoV-2 Vaccine Any vaccine that may prevent coronavirus disease-2019 (COVID-19) that is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). 812 C191387 Pharmacological Therapy Fully vaccinated C191404 Therapies for COVID-19 >2 wk after completion of the relevant vaccination series (currently 2 doses for the mRNA vaccines) C189090 Vaccinated for COVID-19 A status indicating that an individual has received a COVID-19 vaccination. 813 C191387 Pharmacological Therapy Partially vaccinated C191404 Therapies for COVID-19 >2 wk from the initial dose of a 2-dose series (currently applies only to the mRNA vaccines) C189098 Partially Vaccinated for COVID-19 A status indicating that an individual has received a COVID-19 vaccination but has not completed a vaccination series. 814 C191387 Pharmacological Therapy Unvaccinated C191404 Therapies for COVID-19 No vaccine, or <2 wk from first vaccine dose C189099 Not Vaccinated for COVID-19 A status indicating that an individual has not received a COVID-19 vaccination. 815 C191387 Pharmacological Therapy Unknown C191404 Therapies for COVID-19 A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 816 C191387 Pharmacological Therapy SARS-CoV-2 vaccine type C191404 Therapies for COVID-19 Type of SARS-CoV-2 vaccine received C189190 COVID-19 Vaccine Administered SARS-CoV-2 Vaccine Administered A question about which COVID-19 vaccine was administered. 817 C191387 Pharmacological Therapy BNT162b2 (Pfizer-BioNTech) C191404 Therapies for COVID-19 C173055 Tozinameran BNT1162b2 SARS-CoV-2 Vaccine || BNT162b2 COVID-19 Vaccine || Pfizer COVID-19 Vaccine || Pfizer-BioNTech COVID-19 Vaccine || SARS-CoV-2 SP mRNA LNP Vaccine BNT162b2 A formulation consisting of lipid nanoparticle (LNP) encapsulating a nucleoside modified messenger RNA (modRNA) encoding an optimized form of the full-length severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike glycoprotein (SP), with potential immunizing and anti-COVID-19 activities. Upon injection of tozinameran, the LNPs bind to the plasma membrane of nearby cells and release SARS-CoV-2 SP mRNA into the cell. The mRNA is then translated by the cellular protein translation machinery to produce SARS-CoV-2 SP. This may stimulate the immune system to induce an antibody and T-cell-mediated immune response. This may provide active immunization against SARS-CoV-2 infection. SP, usually found on the surface of SARS-CoV-2, plays an essential role in the infection pathway of the SARS-CoV-2 virus. 818 C191387 Pharmacological Therapy mRNA-1273 (Moderna) C191404 Therapies for COVID-19 C172736 Elasomeran LNP-encapsulated mRNA-based SARS-CoV-2 Vaccine mRNA-1273 || Lipid Nanoparticle-encapsulated mRNA-based SARS-CoV-2 Vaccine mRNA-1273 || Moderna COVID-19 Vaccine A vaccine consisting of a lipid nanoparticle (LNP) encapsulating a messenger RNA (mRNA) encoding the full-length, prefusion stabilized spike (S) protein of SARS-CoV-2, with potential immunizing activity against SARS-CoV-2. Upon administration of elasomeran, the lipid nanoparticle binds to the plasma membrane of cells and releases the mRNA into the cells. The mRNA is then translated by ribosomes to produce the SARS-CoV-2 S protein. This may activate both humoral and cellular immune responses which may result in protection against SARS-CoV-2 infection. 819 C191387 Pharmacological Therapy Ad26.COV2.S (Johnson & Johnson/Janssen) C191404 Therapies for COVID-19 C176055 COVID-19 Vaccine Ad26.COV2.S Ad26-encoding SARS-CoV-2 Spike Protein Vaccine || Ad26.COV2.S || Ad26COVS1 || Johnson and Johnson COVID-19 Vaccine A coronavirus vaccine composed of a genetically engineered, replication-incompetent, adenovirus serotype 26 (Ad26) vector expressing the stabilized pre-fusion spike (S) protein of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), with potential immunomodulating and anti-COVID-19 activities. Upon intramuscular administration of the COVID-19 vaccine Ad26.COV2.S, the Ad26 infects human cells, which produces SARS-CoV-2 S protein. The released S protein activates the immune system to induce a humoral and cell-mediated immune response against SARS-CoV-2. This may prevent SARS-CoV-2 infection and inhibit viral replication. S protein, usually found on the surface of SARS-CoV-2, plays an essential role in the infection pathway of the SARS-CoV-2 virus. 820 C191387 Pharmacological Therapy Other, specify C191404 Therapies for COVID-19 C157106 Specify Other A directive to indicate a response not listed. 821 C191387 Pharmacological Therapy Unknown C191404 Therapies for COVID-19 A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 822 C191387 Pharmacological Therapy Date of SARS-CoV-2 immunization C191404 Therapies for COVID-19 Date that SARS-CoV-2 immunization was completed. This would be the date of the second dose for a 2-dose series vaccine (currently the mRNA vaccines). Do not use date of booster dose. C191534 Date of SARS-CoV-2 Immunization Date of SARS-CoV-2 Vaccination The date that SARS-CoV-2 immunization was completed. In a vaccine series, this corresponds to the date of the last vaccination but does not include booster doses. 823 C191387 Pharmacological Therapy Manufacturer of SARS-CoV-2 vaccine received C191404 Therapies for COVID-19 The manufacturer of the vaccine received C191571 Manufacturer of SARS-CoV-2 Vaccine Received The company that produced the COVID-19 vaccine that was received. 824 C191387 Pharmacological Therapy Pfizer/BioNTech C191404 Therapies for COVID-19 C191584 Pfizer/BioNTech The collaboration of two pharmaceutical companies, Pfizer and BioNTech, that together developed COVID-19 mRNA vaccines. 825 C191387 Pharmacological Therapy Moderna C191404 Therapies for COVID-19 C177124 Moderna An American pharmaceutical and biotechnology company based in Cambridge, Massachusetts. The company focuses on drug discovery, drug development, and vaccine technologies based exclusively on messenger RNA. 826 C191387 Pharmacological Therapy Johnson & Johnson C191404 Therapies for COVID-19 C164191 Janssen Pharmaceuticals JRD || Janssen || Janssen Pharmaceutica || Janssen Research and Development A pharmaceutical company providing medicines for an array of health concerns in several therapeutic areas. The company conducts research and development into oncology, mental illness, neurological disorders, gastrointestinal disorders, fungal infection, and allergies. 827 C191387 Pharmacological Therapy Date of SARS-CoV-2 booster dose C191404 Therapies for COVID-19 Date that SARS-CoV-2 booster was given C191533 Date of SARS-CoV-2 Booster Dose Date of SARS-CoV-2 Booster Vaccination The date that SARS-CoV-2 booster vaccination was received. 828 C191387 Pharmacological Therapy IVIG C191404 Therapies for COVID-19 Blood product derived from pooled Ig antibodies extracted from donor plasma delivered intravenously C121331 Intravenous Immunoglobulin Therapy Gamma Globulin Therapy || IVIG Therapy || Immune Globulin Therapy The administration of a blood product derived from pooled IgG antibodies extracted from donor plasma delivered intravenously. It is used to treat multiple disorders, including immunodeficiencies, autoimmune disorders, and active infections. 829 C191387 Pharmacological Therapy COVID-19 Supportive Care C191406 Therapies for Supportive Care During COVID-19 Infection C191628 COVID-19 Supportive Care Non-curative therapy given to treat symptomatic SARS-CoV-2 infection. 830 C191387 Pharmacological Therapy IV vasopressors C191406 Therapies for Supportive Care During COVID-19 Infection IV vasopressor agents are a group of medicines that augment blood pressure predominantly through an increase in vascular tone. C126567 Vasopressor Anti-hypotensive Agent || Antihypotensive Agent Any substance used in the treatment of hypotension. A vasopressor agent increases reduced blood pressure. 831 C191387 Pharmacological Therapy Norepinephrine C191406 Therapies for Supportive Care During COVID-19 Infection Norepinephrine is a sympathomimetic drug that increases blood pressure and enhances ventricular contractility. C62098 Norepinephrine, DL- (+/-)-Noradrenaline || Arterenol || Noradrenaline || Norepinephrine A synthetic phenylethylamine that mimics the sympathomimetic actions of the endogenous norepinephrine. Norepinephrine acts directly on the alpha- and beta-adrenergic receptors. Clinically, norepinephrine is used as a peripheral vasoconstrictor that causes constriction of arterial and venous beds via its alpha-adrenergic action. It is also used as a potent inotropic and chronotropic stimulator of the heart mediated through its beta-1 adrenergic action. 832 C191387 Pharmacological Therapy Epinephrine C191406 Therapies for Supportive Care During COVID-19 Infection Epinephrine is a sympathomimetic drug that increases blood pressure and enhances ventricular contractility. C473 Therapeutic Epinephrine Adrenaline || Epinephrine The synthetic form of the naturally occurring sympathomimetic amine with vasoconstricting, intraocular pressure-reducing, and bronchodilating activities. By stimulating vascular alpha-adrenergic receptors, epinephrine causes vasoconstriction, thereby increasing vascular resistance and blood pressure. When administered in the conjunctiva, this agent binds to alpha-adrenergic receptors in the iris sphincter muscle, resulting in vasoconstriction, a decrease in the production of aqueous humor, and a lowering of intraocular pressure. Through its beta1 receptor-stimulating actions, epinephrine increases the force and rate of myocardial contraction and relaxes bronchial smooth muscle, resulting in bronchodilation. 833 C191387 Pharmacological Therapy Dopamine C191406 Therapies for Supportive Care During COVID-19 Infection Dopamine is a sympathomimetic drug that increases blood pressure and enhances ventricular contractility. C81078 Dopa, DL- The racemic mixture of the precursor of dopamine L-DOPA (levodopa) and D-DOPA, with antiparkinsonian properties. L-DOPA is converted to dopamine by DOPA decarboxylase and can cross the blood-brain barrier (BBB). When in the brain, levodopa is decarboxylated to dopamine and stimulates the dopaminergic receptors, thereby compensating for the depleted supply of endogenous dopamine seen in Parkinson's disease. 834 C191387 Pharmacological Therapy Vasopressin C191406 Therapies for Supportive Care During COVID-19 Infection Vasopressin is a vasoactive hormone used synergistically with another sympathomimetic drug (typically norepinephrine) to increase and maintain peripheral vascular tone in patients with distributive shock. C184932 Vasopressin, Unspecified An unspecified form of vasopressin, with antidiuretic property. Synthesized in the hypothalamus and stored in and released from the posterior lobe of the pituitary, vasopressin regulates extracellular fluid volume, acts as a vasoconstrictor, and increases blood pressure and systemic vascular resistance. 835 C191387 Pharmacological Therapy Phenylephrine C191406 Therapies for Supportive Care During COVID-19 Infection Phenylephrine is a sympathomimetic drug whose primary activity results from stimulation of the alpha receptors of the vasculature, resulting in vasoconstriction while producing comparatively mild direct cardiac effects. C62067 Phenylephrine A direct-acting sympathomimetic amine chemically related to adrenaline and ephedrine with potent vasoconstrictor property. Phenylephrine is a post-synaptic alpha-adrenergic receptor agonist that causes vasoconstriction, increases systolic/diastolic pressures, reflex bradycardia, and stroke output. 836 C191387 Pharmacological Therapy Other C191406 Therapies for Supportive Care During COVID-19 Infection A proper value is applicable but not known. C17649 Other Other or Miscellaneous Different than the one(s) previously specified or mentioned. 837 C191387 Pharmacological Therapy No abnormalities related to cardiovascular diseases || None C191406 Therapies for Supportive Care During COVID-19 Infection C41132 None No person or thing, nobody, not any. 838 C191387 Pharmacological Therapy IV inotropic agent C191406 Therapies for Supportive Care During COVID-19 Infection IV positive inotropic agents are a group of medicines that stimulate and increase the force of contraction of the heart muscle. C78322 Cardiotonic Agent Cardiotonic Inotropic Agent any agent having a favorable effect on the function of the heart. 839 C191387 Pharmacological Therapy Milrinone C191406 Therapies for Supportive Care During COVID-19 Infection Milrinone is a phosphodiesterase 3 inhibitor that works to increase the heart's contractility, decrease pulmonary vascular resistance, and as a systemic vasodilator. C61848 Milrinone A cardiovascular bipyridine agent and phosphodiesterase (PDE) III inhibitor, with positive inotropic and vasodilator activities. Upon administration, milrinone selectively inhibits PDE-mediated degradation of cyclic adenosine monophosphate (cAMP) in the heart and vascular muscles, thereby increasing cAMP and activates protein kinase A (PKA). This leads to phosphorylation of calcium ion channels and improve myocardium contractile force. Milrinone also causes vasodilation in arteriolar and venous vascular smooth muscle. 840 C191387 Pharmacological Therapy Dobutamine C191406 Therapies for Supportive Care During COVID-19 Infection Dobutamine is a direct-acting inotropic agent whose primary activity results from stimulation of the ? receptors of the heart while producing comparatively mild chronotropic, hypertensive, arrhythmogenic, and vasodilative effects. C61733 Dobutamine A synthetic catecholamine with sympathomimetic activity. Dobutamine is a direct-acting inotropic agent and an adrenergic agonist that stimulates primarily the beta-1 adrenoceptor, with lesser effect on beta-2 or alpha receptors. Via beta-1 adrenoceptor of the heart, this agent induces positive inotropic effect with minimal changes in chronotropic activities or systemic vascular resistance. Dobutamine also causes vasodilation by stimulating beta-2 adrenergic receptors in blood vessels, augmented by reflex vasoconstriction resulting in increased cardiac output. 841 C191387 Pharmacological Therapy Other C191406 Therapies for Supportive Care During COVID-19 Infection A proper value is applicable but not known. C17649 Other Other or Miscellaneous Different than the one(s) previously specified or mentioned. 842 C191387 Pharmacological Therapy No abnormalities related to cardiovascular diseases || None C191406 Therapies for Supportive Care During COVID-19 Infection C41132 None No person or thing, nobody, not any. 843 C191387 Pharmacological Therapy COVID-19-specific intermediate- or full-dose anticoagulation C191406 Therapies for Supportive Care During COVID-19 Infection Intermediate- or full-dose anticoagulation used to prevent VTE complications due to SARS-CoV-2 specifically and not because of documented VTE or another noninfectious indication. Note that this excludes the low-dose prophylactic anticoagulation often given to inpatients for VTE prophylaxis (see below). C191450 COVID-19-specific Anticoagulation Medical prophylactic anticoagulation therapy given to COVID-19 patients to prevent adverse outcomes. 844 C191387 Pharmacological Therapy Heparin || Unfractionated heparin C191406 Therapies for Supportive Care During COVID-19 Infection Heparin is an indirect thrombin inhibitor composed of a mixture of heterogeneous mucopolysaccharides with a molecular weight of 5-30 kDa. C539 Heparin Unfractionated Heparin A sulfur-rich glycosaminoglycan with anticoagulant property. Heparin binds to antithrombin III to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors, such as factors IX, X, XI, and XII, thereby preventing the polymerization of fibrinogen to fibrin and the subsequent formation of clots. 845 C191387 Pharmacological Therapy Low-molecular-weight heparin C191406 Therapies for Supportive Care During COVID-19 Infection Low-molecular-weight heparin compounds are fractions of heparin that primarily act by inhibiting the activated clotting factor X. Examples include enoxaparin and dalteparin. C2578 Low Molecular Weight Heparin Substances comprised of fragmented heparin molecules derived from unfractionated heparin that bind to antithrombin III with a molecular weight ranging from 1000 to 10,000 daltons, which causes changes in property from unfractionated heparin, including decreased protein binding, enhanced bioavailability, decreased platelet interaction, and decreased binding to thrombin. 846 C191387 Pharmacological Therapy DOAC C191406 Therapies for Supportive Care During COVID-19 Infection Oral anticoagulant that directly inhibits specific proteins within the coagulation cascade (rivaroxaban, apixaban, dabigatran, or edoxaban) C180619 Direct Oral Anticoagulant DOAC || DOACs || Direct Oral Anticoagulants || NOAC || Novel Oral Anticoagulant An agent taken orally to prevent blood clot formation by directly inhibiting certain coagulation factors including thrombin (factor IIa) or factor Xa. 847 C191387 Pharmacological Therapy Warfarin C191406 Therapies for Supportive Care During COVID-19 Infection A vitamin K antagonist anticoagulant C945 Warfarin A synthetic anticoagulant. Warfarin inhibits the regeneration of vitamin K1 epoxide and so the synthesis of vitamin K dependent clotting factors, which include Factors II, VII, IX and X, and the anticoagulant proteins C and S. This inhibition results in a sequential depression of Factors VII, IX, X and II activities. Vitamin K is an essential cofactor for the post ribosomal synthesis of the vitamin K dependent clotting factors. The vitamin promotes the biosynthesis of gamma-carboxyglutamic acid residues in these proteins which are essential for biological activity. 848 C191387 Pharmacological Therapy Yes C191406 Therapies for Supportive Care During COVID-19 Infection ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 849 C191387 Pharmacological Therapy No C191406 Therapies for Supportive Care During COVID-19 Infection C49487 No The non-affirmative response to a question. 850 C191387 Pharmacological Therapy Unknown C191406 Therapies for Supportive Care During COVID-19 Infection A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 851 C191387 Pharmacological Therapy COVID-19-specific anticoagulation dosing strategy C191406 Therapies for Supportive Care During COVID-19 Infection For patients receiving intermediate- or full-dose anticoagulation because of SARS-CoV-2 specifically and not because of documented VTE or another noninfectious indication. C191425 COVID-19-specific Anticoagulation Dosing Strategy A scheme to approach the prophylactic anticoagulation of COVID-19 patients. 852 C191387 Pharmacological Therapy Full dose C191406 Therapies for Supportive Care During COVID-19 Infection Standard treatment dose C191521 COVID-19-specific Full Anticoagulation Dose A dosing strategy that targets a standard treatment dose of an anticoagulant for the treatment of COVID-19. 853 C191387 Pharmacological Therapy Intermediate dose C191406 Therapies for Supportive Care During COVID-19 Infection Intermediate dose is defined here as a dosing strategy targeting levels of anticoagulation less than standard treatment doses but greater than standard VTE prophylaxis doses. C191522 COVID-19-specific Intermediate Anticoagulation Dose A dosing strategy that targets a less than standard treatment dose but greater than a standard prophylactic dose of an anticoagulant for the treatment of COVID-19. 854 C191387 Pharmacological Therapy Unknown C191406 Therapies for Supportive Care During COVID-19 Infection A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 855 C191387 Pharmacological Therapy Anticoagulation for VTE prophylaxis C191406 Therapies for Supportive Care During COVID-19 Infection Administration of a prophylactic dose (not therapeutic dose) of anticoagulant to prevent VTE during hospitalization for COVID-19 C116684 Thromboembolism Prophylaxis The use of medication to prevent the formation of clots and emboli. 856 C191387 Pharmacological Therapy Yes C191406 Therapies for Supportive Care During COVID-19 Infection ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 857 C191387 Pharmacological Therapy No C191406 Therapies for Supportive Care During COVID-19 Infection C49487 No The non-affirmative response to a question. 858 C191387 Pharmacological Therapy Unknown C191406 Therapies for Supportive Care During COVID-19 Infection A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 859 C191387 Pharmacological Therapy Anticoagulant medication administered for VTE prophylaxis C191406 Therapies for Supportive Care During COVID-19 Infection Name of the anticoagulant medication administered to prevent VTE during hospitalization for COVID-19 C263 Anticoagulant Agent Anticoagulant Drugs || Anticoagulants Any agent capable of preventing blood clot formation. 860 C191387 Pharmacological Therapy Heparin || Unfractionated heparin C191406 Therapies for Supportive Care During COVID-19 Infection Heparin is an indirect thrombin inhibitor composed of a mixture of heterogeneous mucopolysaccharides with a molecular weight of 5-30 kDa. C539 Heparin Unfractionated Heparin A sulfur-rich glycosaminoglycan with anticoagulant property. Heparin binds to antithrombin III to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors, such as factors IX, X, XI, and XII, thereby preventing the polymerization of fibrinogen to fibrin and the subsequent formation of clots. 861 C191387 Pharmacological Therapy Low-molecular-weight heparin C191406 Therapies for Supportive Care During COVID-19 Infection Low-molecular-weight heparin compounds are fractions of heparin that primarily act by inhibiting the activated clotting factor X. Examples include enoxaparin and dalteparin. C2578 Low Molecular Weight Heparin Substances comprised of fragmented heparin molecules derived from unfractionated heparin that bind to antithrombin III with a molecular weight ranging from 1000 to 10,000 daltons, which causes changes in property from unfractionated heparin, including decreased protein binding, enhanced bioavailability, decreased platelet interaction, and decreased binding to thrombin. 862 C191387 Pharmacological Therapy Fondaparinux C191406 Therapies for Supportive Care During COVID-19 Infection Fondaparinux is a synthetic anticoagulant based on the pentasaccharide sequence that makes up the minimal antithrombin-binding region of heparin. C73142 Fondaparinux Natural Heparin Pentasaccharide A synthetic glucopyranoside with antithrombotic activity. Fondaparinux selectively binds to antithrombin III, thereby potentiating the innate neutralization of activated factor X (Factor Xa) by antithrombin. Neutralization of Factor Xa inhibits its activity and interrupts the blood coagulation cascade, thereby preventing thrombin formation and thrombus development. 863 C191387 Pharmacological Therapy Bivalirudin C191406 Therapies for Supportive Care During COVID-19 Infection Bivalirudin is a semisynthetic derivative of hirudin and is a highly specific inhibitor of thrombin. C47415 Bivalirudin Hirulog A 20 amino acid long synthetic peptide with thrombin-specific anticoagulant properties. Bivalirudin reversibly binds thrombin, free as well as clot bound, at the catalytic site and the anion-binding exosite, thereby preventing the formation and activation of fibrin, factor XIIIa, and other coagulation factors. This drug is primarily used during coronary angioplasty procedures, in combination with aspirin, in patients with unstable angina. 864 C191387 Pharmacological Therapy Other C191406 Therapies for Supportive Care During COVID-19 Infection A proper value is applicable but not known. C17649 Other Other or Miscellaneous Different than the one(s) previously specified or mentioned. 865 C191387 Pharmacological Therapy Unknown C191406 Therapies for Supportive Care During COVID-19 Infection A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 866 C191387 Pharmacological Therapy Renal replacement therapy C191406 Therapies for Supportive Care During COVID-19 Infection Use of renal replacement therapy during hospitalization for COVID-19 in a patient without end-stage renal disease prior to such hospitalization. These therapies may include CRRT, prolonged intermittent renal replacement therapy, IHD, or other forms of renal replacement therapy. C126400 Renal Replacement Therapy RRT Treatments that substitute for the blood-filtering function of the kidneys. It includes dialysis (hemodialysis or peritoneal dialysis), hemofiltration, and hemodiafiltration. Kidney transplant may also be considered a renal replacement therapy. 867 C191387 Pharmacological Therapy Yes C191406 Therapies for Supportive Care During COVID-19 Infection ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 868 C191387 Pharmacological Therapy No C191406 Therapies for Supportive Care During COVID-19 Infection C49487 No The non-affirmative response to a question. 869 C191387 Pharmacological Therapy Unknown C191406 Therapies for Supportive Care During COVID-19 Infection A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 870 C191388 Therapeutic and Supportive Procedures for COVID-19 MCS C191401 Mechanical Support MCS required. MCS is circulatory support using implanted devices most commonly used to supplement vasopressors and inotropes in the management of patients with low cardiac output and cardiogenic shock. C99540 Mechanical Circulatory Support Use of a device to replace the function of a cardiac ventricle. This includes use of cardiopulmonary bypass, left ventricular assist device (LVAD), intra-aortic balloon pump (IABP) and/or extracorporeal membrane oxygenation (ECMO). 871 C191388 Therapeutic and Supportive Procedures for COVID-19 Yes C191401 Mechanical Support ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 872 C191388 Therapeutic and Supportive Procedures for COVID-19 No C191401 Mechanical Support C49487 No The non-affirmative response to a question. 873 C191388 Therapeutic and Supportive Procedures for COVID-19 Unknown C191401 Mechanical Support A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 874 C191388 Therapeutic and Supportive Procedures for COVID-19 Implantation of temporary MCS device C191401 Mechanical Support MCS device used. MCS devices are the implanted devices used to supplement vasopressors and inotropes in the management of patients with low cardiac output and cardiogenic shock. C191468 Implantation of Temporary Mechanical Circulatory Support Device Implantation of Temporary MCS Device Placement of a short-term device used to supplement medical therapy (vasopressors and inotropes) in the management of patients with low cardiac output and cardiogenic shock. 875 C191388 Therapeutic and Supportive Procedures for COVID-19 IABP C191401 Mechanical Support C100087 Intra-Aortic Balloon Pump A medical device that increases myocardial oxygen perfusion while at the same time increasing cardiac output. (ACC) 876 C191388 Therapeutic and Supportive Procedures for COVID-19 Impella C191401 Mechanical Support C191592 Catheter-based Miniaturized Left Ventricular Assist Device Impella (BR) A percutaneously implanted miniaturized heart pump. 877 C191388 Therapeutic and Supportive Procedures for COVID-19 TandemHeart C191401 Mechanical Support C191428 Percutaneous Ventricular Assist Device PVAD || TandemHeart (BR) A percutaneously implanted heart pump. 878 C191388 Therapeutic and Supportive Procedures for COVID-19 VA ECMO C191401 Mechanical Support ECMO, in which a venous cannula is usually placed in the right or left common femoral vein for extraction, and an arterial cannula is usually placed into the right or left femoral artery for infusion, with an oxygenator between the extraction and infusion cannulae. Used to provide circulatory support and to facilitate gas exchange. C191550 Veno-Arterial Extracorporeal Membrane Oxygenation VA ECMO || Venoarterial Extracorporeal Membrane Oxygenation Extracorporeal membrane oxygenation (ECMO) in which a venous cannula is typically placed in the right or left common femoral vein for extraction, and an arterial cannula is usually placed into the right or left femoral artery for infusion, with an oxygenator between the extraction and infusion cannulae. 879 C191388 Therapeutic and Supportive Procedures for COVID-19 VV ECMO C191401 Mechanical Support ECMO to provide adequate gas exchange, usually in respiratory failure/ARDS. The access cannula is usually placed in the inferior vena cava via the femoral vein. The tip of the return cannula should sit close to the right atrium, and it may be placed via the femoral or internal jugular vein. C191553 Veno-Venous Extracorporeal Membrane Oxygenation VV ECMO || Venovenous Extracorporeal Membrane Oxygenation Extracorporeal membrane oxygenation (ECMO) to provide adequate gas exchange, usually in respiratory failure/ARDS. The access cannula is usually placed in the inferior vena cava via the femoral vein. The tip of the return cannula is placed close to the right atrium, and it may be placed via the femoral or internal jugular vein. 880 C191388 Therapeutic and Supportive Procedures for COVID-19 Other C191401 Mechanical Support A proper value is applicable but not known. C17649 Other Other or Miscellaneous Different than the one(s) previously specified or mentioned. 881 C191388 Therapeutic and Supportive Procedures for COVID-19 Unknown C191401 Mechanical Support A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 882 C191388 Therapeutic and Supportive Procedures for COVID-19 Implantation of a long-term durable MCS device performed C191401 Mechanical Support Mechanical pump to help pump blood from the ventricle(s) to the body, used in the management of patients with low cardiac output and cardiogenic shock C191467 Implantation of Long Term Durable Mechanical Circulatory Support Device Implantation of Long Term Durable MCS Device Placement of a permanent device used to supplement medical therapy (vasopressors and inotropes) in the management of patients with low cardiac output and cardiogenic shock. 883 C191388 Therapeutic and Supportive Procedures for COVID-19 LVAD C191401 Mechanical Support C80473 Left Ventricular Assist Device A mechanical pump which also includes a control system and an energy supply. It receives blood from the left ventricle and delivers it to the aorta, thus helping the heart to pump sufficient blood to the body. 884 C191388 Therapeutic and Supportive Procedures for COVID-19 RVAD C191401 Mechanical Support C80472 Right Ventricular Assist Device A mechanical pump which also includes a control system and an energy supply. It receives blood from the right ventricle and delivers it to the pulmonary artery, thus helping the heart to pump sufficient blood to the body. 885 C191388 Therapeutic and Supportive Procedures for COVID-19 BiVAD C191401 Mechanical Support C191574 Biventricular Assist Device BiVAD A mechanical pump that is implanted to augment the function of both ventricles of the heart, typically as a bridge to transplantation. 886 C191388 Therapeutic and Supportive Procedures for COVID-19 Total artificial heart C191401 Mechanical Support C191576 Total Artificial Heart A prosthetic device used to replace the function of both cardiac ventricles and all four cardiac valves, typically as a bridge to transplantation. 887 C191388 Therapeutic and Supportive Procedures for COVID-19 No abnormalities related to cardiovascular diseases || None C191401 Mechanical Support C41132 None No person or thing, nobody, not any. 888 C191388 Therapeutic and Supportive Procedures for COVID-19 Date of MCS C191401 Mechanical Support Date that MCS was used C191531 Date of Mechanical Circulatory Support Date of MCS The date that mechanical circulatory support was utilized. 889 C191388 Therapeutic and Supportive Procedures for COVID-19 MCS Time C191401 Mechanical Support Time that MCS was used C191639 Time of Mechanical Circulatory Support Time of MCS The time that mechanical circulatory support was utilized. 890 C191388 Therapeutic and Supportive Procedures for COVID-19 Noninvasive mechanical ventilatory support C191401 Mechanical Support A type of mechanical ventilation procedure that uses a noninvasive means, such as a face mask or nasal mask, to deliver oxygenated air into the lungs C171457 Non-Invasive Mechanical Ventilation NIV || Non-Invasive Ventilation A type of mechanical ventilation procedure that uses a non-invasive means, such as a face mask or nasal mask, to deliver oxygenated air into the lungs. 891 C191388 Therapeutic and Supportive Procedures for COVID-19 CPAP C191401 Mechanical Support A form of noninvasive mechanical pressure support ventilation that uses a CPAP level to support spontaneous breathing activity C124040 Continuous Positive Airway Pressure A form of non-invasive mechanical pressure support ventilation that uses a continuous positive airway pressure level to support spontaneous breathing activity. 892 C191388 Therapeutic and Supportive Procedures for COVID-19 BiPAP C191401 Mechanical Support A type of noninvasive mechanical ventilation procedure that that uses BiPAP to support spontaneous breathing activity C124039 Biphasic Positive Airway Pressure Bilevel Positive Airway Pressure Ventilation A form of non-invasive mechanical pressure support ventilation that uses a time-cycled change of the applied positive airway pressure level to support spontaneous breathing activity. 893 C191388 Therapeutic and Supportive Procedures for COVID-19 No abnormalities related to cardiovascular diseases || None C191401 Mechanical Support C41132 None No person or thing, nobody, not any. 894 C191388 Therapeutic and Supportive Procedures for COVID-19 Unknown C191401 Mechanical Support A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 895 C191388 Therapeutic and Supportive Procedures for COVID-19 Invasive mechanical ventilatory support C191401 Mechanical Support Artificial ventilation to assist or replace spontaneous breathing through tracheostomy or endotracheal tubes C191573 Invasive Mechanical Ventilation A type of mechanical ventilation procedure that uses an endotracheal or tracheostomy tube to deliver pressurized oxygenated air into the lungs. 896 C191388 Therapeutic and Supportive Procedures for COVID-19 Mechanical ventilation C191401 Mechanical Support Mechanical ventilation technique is a life-sustaining technique through which gas is moved toward and from the lungs through an external device connected directly to the patient. C70909 Mechanical Ventilation A method to mechanically assist or replace spontaneous breathing in patients by use of a powered device that forces oxygenated air into the lungs. 897 C191388 Therapeutic and Supportive Procedures for COVID-19 Adaptive servo-ventilation C191401 Mechanical Support Positive airway pressure therapy in which air pressure target is adjusted according to the patient's breathing patterns C191582 Adaptive Servo-Ventilation ASV || Adaptive Servo Ventilation A non-invasive ventilatory treatment that continuously adjusts positive airway pressure (PAP) to prompt breathing when needed based on a patient's breathing pattern. 898 C191388 Therapeutic and Supportive Procedures for COVID-19 No abnormalities related to cardiovascular diseases || None C191401 Mechanical Support C41132 None No person or thing, nobody, not any. 899 C191388 Therapeutic and Supportive Procedures for COVID-19 Oxygen therapy C191401 Mechanical Support The administration of oxygen to an individual, usually to aid in respiration C94624 Oxygen Therapy The administration of oxygen to an individual, usually to aid in respiration. 900 C191388 Therapeutic and Supportive Procedures for COVID-19 Yes C191401 Mechanical Support ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 901 C191388 Therapeutic and Supportive Procedures for COVID-19 No C191401 Mechanical Support C49487 No The non-affirmative response to a question. 902 C191388 Therapeutic and Supportive Procedures for COVID-19 Unknown C191401 Mechanical Support A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 903 C191388 Therapeutic and Supportive Procedures for COVID-19 Maximum fraction of inspired oxygen (FiO2) C191401 Mechanical Support Maximum molar fraction of oxygen in an inhaled gas C38082 Fraction of Inspired Oxygen The molar fraction of oxygen in an inhaled gas. 904 C191388 Therapeutic and Supportive Procedures for COVID-19 PEEP C191401 Mechanical Support The maximum end-expiratory alveolar pressure above atmospheric pressure supplied to patients on invasive or noninvasive ventilation C191605 Positive End-Expiratory Pressure PEEP The pressure applied by the ventilator at the end of each breath to ensure that the alveoli are not so prone to collapse. 905 C191388 Therapeutic and Supportive Procedures for COVID-19 FiO2/PEEP ratio C191401 Mechanical Support Ratio of FiO2 to PEEP used to achieve desired arterial oxygenation C191613 FiO2/PEEP The ratio of fraction of inspired oxygen (FiO2) to positive end-expiratory pressure (PEEP). This measured value may be adjusted on a mechanical ventilator to optimize treatment. 906 C191388 Therapeutic and Supportive Procedures for COVID-19 VA ECMO C191401 Mechanical Support ECMO, in which a venous cannula is usually placed in the right or left common femoral vein for extraction, and an arterial cannula is usually placed into the right or left femoral artery for infusion, with an oxygenator between the extraction and infusion cannulae. Used to provide circulatory support and to facilitate gas exchange. C191550 Veno-Arterial Extracorporeal Membrane Oxygenation VA ECMO || Venoarterial Extracorporeal Membrane Oxygenation Extracorporeal membrane oxygenation (ECMO) in which a venous cannula is typically placed in the right or left common femoral vein for extraction, and an arterial cannula is usually placed into the right or left femoral artery for infusion, with an oxygenator between the extraction and infusion cannulae. 907 C191388 Therapeutic and Supportive Procedures for COVID-19 Yes C191401 Mechanical Support ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 908 C191388 Therapeutic and Supportive Procedures for COVID-19 No C191401 Mechanical Support C49487 No The non-affirmative response to a question. 909 C191388 Therapeutic and Supportive Procedures for COVID-19 Unknown C191401 Mechanical Support A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 910 C191388 Therapeutic and Supportive Procedures for COVID-19 VV ECMO C191401 Mechanical Support ECMO to provide adequate gas exchange, usually in respiratory failure/ARDS. The access cannula is usually placed in the inferior vena cava via the femoral vein. The tip of the return cannula should sit close to the right atrium, and it may be placed via the femoral or internal jugular vein. C191553 Veno-Venous Extracorporeal Membrane Oxygenation VV ECMO || Venovenous Extracorporeal Membrane Oxygenation Extracorporeal membrane oxygenation (ECMO) to provide adequate gas exchange, usually in respiratory failure/ARDS. The access cannula is usually placed in the inferior vena cava via the femoral vein. The tip of the return cannula is placed close to the right atrium, and it may be placed via the femoral or internal jugular vein. 911 C191388 Therapeutic and Supportive Procedures for COVID-19 Yes C191401 Mechanical Support ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 912 C191388 Therapeutic and Supportive Procedures for COVID-19 No C191401 Mechanical Support C49487 No The non-affirmative response to a question. 913 C191388 Therapeutic and Supportive Procedures for COVID-19 Unknown C191401 Mechanical Support A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 914 C191388 Therapeutic and Supportive Procedures for COVID-19 Prone positioning in ventilated patient C191401 Mechanical Support Positioning of a mechanically ventilated patient so that their anterior chest is dependent, which allows for improved oxygenation by ameliorating the ventral-dorsal transpulmonary pressure difference, reducing dorsal lung compression, and improving lung perfusion. C173751 Prone Ventilation Positioning of a mechanically ventilated patient so that their anterior chest is dependent which allows for improved oxygenation by ameliorating the ventral-dorsal transpulmonary pressure difference, reducing dorsal lung compression, and improving lung perfusion. 915 C191388 Therapeutic and Supportive Procedures for COVID-19 Yes C191401 Mechanical Support ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 916 C191388 Therapeutic and Supportive Procedures for COVID-19 No C191401 Mechanical Support C49487 No The non-affirmative response to a question. 917 C191388 Therapeutic and Supportive Procedures for COVID-19 Unknown C191401 Mechanical Support A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 918 C191388 Therapeutic and Supportive Procedures for COVID-19 Cardiac arrest requiring CPR C191401 Mechanical Support Cardiac arrest that is treated by CPR or defibrillation, regardless of outcome C141268 Cardiac Arrest Requiring Cardiopulmonary Resuscitation Cardiac arrest that is treated by CPR and/or defibrillation, regardless of outcome. 919 C191388 Therapeutic and Supportive Procedures for COVID-19 Yes C191401 Mechanical Support ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 920 C191388 Therapeutic and Supportive Procedures for COVID-19 No C191401 Mechanical Support C49487 No The non-affirmative response to a question. 921 C191388 Therapeutic and Supportive Procedures for COVID-19 Unknown C191401 Mechanical Support A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 922 C191388 Therapeutic and Supportive Procedures for COVID-19 Date of CPR for cardiac arrest C191401 Mechanical Support Date that CPR for cardiac arrest was performed C191525 Date of Cardiopulmonary Resuscitation for Cardiac Arrest Date of CPR for cardiac arrest The date that cardiopulmonary resuscitation (CPR) for cardiac arrest was performed. 923 C191388 Therapeutic and Supportive Procedures for COVID-19 Time of CPR for cardiac arrest C191401 Mechanical Support Time that CPR for cardiac arrest was performed C191640 Time of Cardiopulmonary Resuscitation for Cardiac Arrest Time of CPR for cardiac arrest The time that cardiopulmonary resuscitation (CPR) for cardiac arrest was performed. 924 C191388 Therapeutic and Supportive Procedures for COVID-19 Electrophysiological Procedure C191399 Electrophysiological Procedures C191466 Electrophysiological Procedure A procedure that is used to correct aberrant electrical impulses associated with cardiac arrhythmias. 925 C191388 Therapeutic and Supportive Procedures for COVID-19 Insertion of a temporary transvenous pacing wire C191399 Electrophysiological Procedures Temporary transvenous pacing wire was inserted. Indications for temporary transvenous pacing are similar to indications for permanent pacing. Typically, temporary transvenous pacing is performed via a pacing wire placed in the RV from a central venous access site. C191469 Temporary Transvenous Pacing Wire Placement Placement of a short-term pacing wire via a central vein to correct for inconsistent and/or ineffective electric impulses to the heart. 926 C191388 Therapeutic and Supportive Procedures for COVID-19 Yes C191399 Electrophysiological Procedures ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 927 C191388 Therapeutic and Supportive Procedures for COVID-19 No C191399 Electrophysiological Procedures C49487 No The non-affirmative response to a question. 928 C191388 Therapeutic and Supportive Procedures for COVID-19 Unknown C191399 Electrophysiological Procedures A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 929 C191388 Therapeutic and Supportive Procedures for COVID-19 Date of temporary transvenous pacing wire insertion C191399 Electrophysiological Procedures Date temporary transvenous pacing wire was inserted C191535 Date of Temporary Transvenous Pacing Wire Insertion The date that the temporary transvenous pacing wire was inserted. 930 C191388 Therapeutic and Supportive Procedures for COVID-19 Implantation of a cardioverter-defibrillator performed C191399 Electrophysiological Procedures A battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity, implanted during current encounter C80435 Implantable Cardioverter-Defibrillator Placement A surgical procedure in which a small, battery-powered device is placed in the chest wall to detect arrhythmias and correct them by delivering a jolt of electricity. 931 C191388 Therapeutic and Supportive Procedures for COVID-19 Yes C191399 Electrophysiological Procedures ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 932 C191388 Therapeutic and Supportive Procedures for COVID-19 No C191399 Electrophysiological Procedures C49487 No The non-affirmative response to a question. 933 C191388 Therapeutic and Supportive Procedures for COVID-19 Unknown C191399 Electrophysiological Procedures A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 934 C191388 Therapeutic and Supportive Procedures for COVID-19 Type of permanent cardioverter-defibrillator implanted C191399 Electrophysiological Procedures A battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity, implanted during current encounter C191499 Type of Permanent Cardioverter-Defibrillator Implanted A question about which type of permanent cardioverter-defibrillator was implanted. 935 C191388 Therapeutic and Supportive Procedures for COVID-19 Transvenous C191399 Electrophysiological Procedures C191564 Transvenous Cardioverter-Defibrillator A cardioverter-defibrillator implanted via a central vein. 936 C191388 Therapeutic and Supportive Procedures for COVID-19 Subcutaneous C191399 Electrophysiological Procedures C191563 Subcutaneous Cardioverter-Defibrillator A cardioverter-defibrillator implanted under the skin. 937 C191388 Therapeutic and Supportive Procedures for COVID-19 Unknown C191399 Electrophysiological Procedures A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 938 C191388 Therapeutic and Supportive Procedures for COVID-19 Date of ICD implantation C191399 Electrophysiological Procedures Date that ICD was implanted C191530 Date of Cardioverter-Defibrillator Implantation The date that the cardioverter-defibrillator was implanted. 939 C191388 Therapeutic and Supportive Procedures for COVID-19 Insertion of a permanent pacemaker C191399 Electrophysiological Procedures A cardiac pacemaker where the generator is implanted inside the body C80434 Pacemaker Placement A surgical procedure in which a small, battery-powered device is placed in the chest wall to transmit electrical impulses to the heart muscles to stimulate contraction. 940 C191388 Therapeutic and Supportive Procedures for COVID-19 Yes C191399 Electrophysiological Procedures ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 941 C191388 Therapeutic and Supportive Procedures for COVID-19 No C191399 Electrophysiological Procedures C49487 No The non-affirmative response to a question. 942 C191388 Therapeutic and Supportive Procedures for COVID-19 Unknown C191399 Electrophysiological Procedures A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 943 C191388 Therapeutic and Supportive Procedures for COVID-19 Electric cardioversion C191399 Electrophysiological Procedures The administration of electric current to correct abnormal heart rhythm C99948 Electric Cardioversion The administration of electric current to correct abnormal heart rhythm. (ACC) 944 C191388 Therapeutic and Supportive Procedures for COVID-19 Yes C191399 Electrophysiological Procedures ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 945 C191388 Therapeutic and Supportive Procedures for COVID-19 No C191399 Electrophysiological Procedures C49487 No The non-affirmative response to a question. 946 C191388 Therapeutic and Supportive Procedures for COVID-19 Unknown C191399 Electrophysiological Procedures A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 947 C191388 Therapeutic and Supportive Procedures for COVID-19 Date of electric cardioversion C191399 Electrophysiological Procedures Date that DC cardioversion was performed C191527 Date of Electric Cardioversion The date that direct current cardioversion was performed. 948 C191388 Therapeutic and Supportive Procedures for COVID-19 Cardiac arrest requiring defibrillation C191399 Electrophysiological Procedures The sudden cessation of cardiac activity in an individual who becomes unresponsive, without normal breathing and no signs of circulation. Certain forms of cardiac arrest (e.g., ventricular fibrillation) may be reversed by defibrillation. C191461 Cardiac Arrest Requiring Defibrillation Cardiac arrest that is treated by defibrillation, regardless of outcome. 949 C191388 Therapeutic and Supportive Procedures for COVID-19 Yes C191399 Electrophysiological Procedures ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 950 C191388 Therapeutic and Supportive Procedures for COVID-19 No C191399 Electrophysiological Procedures C49487 No The non-affirmative response to a question. 951 C191388 Therapeutic and Supportive Procedures for COVID-19 Unknown C191399 Electrophysiological Procedures A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 952 C191388 Therapeutic and Supportive Procedures for COVID-19 Date of defibrillation C191399 Electrophysiological Procedures Date that defibrillation was performed C191526 Date of Defibrillation The date that defibrillation was performed. 953 C191388 Therapeutic and Supportive Procedures for COVID-19 Invasive Revascularization Therapy C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment C191567 Invasive Revascularization Therapy A procedure undertaken to re-establish blood flow through a vessel via introduction of a medical device. 954 C191388 Therapeutic and Supportive Procedures for COVID-19 PCI C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment Any attempt (successful or unsuccessful) to treat a stenosis by any technique, or even failed attempts to cross the stenosis with a wire or device. C99521 Percutaneous Coronary Intervention The placement of an angioplasty guide wire, balloon, or other device (e.g. stent, atherectomy, brachytherapy, or thrombectomy catheter) into a native coronary artery or coronary artery bypass graft for the purpose of mechanical coronary revascularization. 955 C191388 Therapeutic and Supportive Procedures for COVID-19 Yes C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 956 C191388 Therapeutic and Supportive Procedures for COVID-19 No C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment C49487 No The non-affirmative response to a question. 957 C191388 Therapeutic and Supportive Procedures for COVID-19 Unknown C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 958 C191388 Therapeutic and Supportive Procedures for COVID-19 Date of PCI C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment Date that PCI was performed C191532 Date of Percutaneous Coronary Intervention Date of PCI The date that percutaneous coronary intervention (PCI) was performed. 959 C191388 Therapeutic and Supportive Procedures for COVID-19 Time of PCI C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment Time that PCI was performed C191641 Time of Percutaneous Coronary Intervention Time of PCI The time that percutaneous coronary intervention (PCI) was performed. 960 C191388 Therapeutic and Supportive Procedures for COVID-19 PCI Status C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment Classification of the urgency of PCI procedure at the time the operator decides to perform the PCI C191577 Percutaneous Coronary Intervention Status PCI Status || PCI Type The classification of the urgency of percutaneous coronary intervention (PCI) at the time the operator decides to perform the procedure. 961 C191388 Therapeutic and Supportive Procedures for COVID-19 Elective C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment The procedure can be performed on an outpatient basis or during a subsequent hospitalization without significant risk of infarction or death. For stable inpatients, the procedure is being performed during this hospitalization for convenience and ease of scheduling and NOT because the patient's clinical situation demands the procedure before discharge. If the diagnostic catheterization was elective and there were no complications, the PCI would also be elective. C191588 Elective Percutaneous Coronary Intervention Elective PCI A percutaneous coronary intervention (PCI) that is performed on an outpatient basis or during a subsequent hospitalization without significant risk of infarction or death. For stable inpatients, the procedure is being performed during their hospitalization for convenience and ease of scheduling but not because the patient's clinical situation demands the procedure before discharge. If the diagnostic catheterization was elective and there were no complications, the PCI would also be considered elective. 962 C191388 Therapeutic and Supportive Procedures for COVID-19 Urgent C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment The procedure is performed on an inpatient basis and before discharge because of significant concerns that there is risk of ischemia, infarction, or death. Patients who are outpatients or in the emergency department at the time that the cardiac catheterization is requested would warrant an admission based on their clinical presentation. C191591 Urgent Percutaneous Coronary Intervention Urgent PCI A percutaneous coronary intervention (PCI) that is performed on an inpatient basis and before discharge because of significant concerns that there is risk of ischemia, infarction, or death. Patients who are outpatients or in the emergency department at the time that the cardiac catheterization is requested would warrant an admission based on their clinical presentation. 963 C191388 Therapeutic and Supportive Procedures for COVID-19 Emergency C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment The procedure is performed as soon as possible because of substantial concerns that ongoing ischemia or infarction could lead to death. "As soon as possible" refers to a case of sufficient acuity that a scheduled case would be cancelled to perform this procedure immediately in the next available room during business hours, or the on-call team would be activated if this were to occur during off-hours. C191589 Emergency Percutaneous Coronary Intervention Emergency PCI A percutaneous coronary intervention (PCI) that is performed as soon as possible because of substantial concerns that ongoing ischemia or infarction could lead to death. "As soon as possible" refers to a case of sufficient acuity that a scheduled case would be cancelled to perform this procedure immediately in the next available room during business hours, or the on-call team would be activated if this were to occur during off-hours. 964 C191388 Therapeutic and Supportive Procedures for COVID-19 Salvage C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment The procedure is a last resort in a patient with cardiogenic shock when the PCI begins (i.e., at the time of introduction into a coronary artery or bypass graft of the first guidewire or intracoronary device for the purpose of mechanical revascularization). Within the last 10 min before the start of the case or during the diagnostic portion of the case, the patient may have received chest compressions for a total of at least 60 s or have been on unanticipated extracorporeal circulatory support (e.g., extracorporeal mechanical oxygenation, or cardiopulmonary support). C191590 Salvage Percutaneous Coronary Intervention Salvage PCI A percutaneous coronary intervention (PCI) that is a last resort in a patient with cardiogenic shock when the PCI begins (i.e., at the time of introduction into a coronary artery or bypass graft of the first guidewire or intracoronary device for the purpose of mechanical revascularization). Within the last 10 minutes before the start of the case, or during the diagnostic portion of the case, the patient may have received chest compressions for a total of at least 60 seconds or have been on unanticipated extracorporeal circulatory support (e.g., extracorporeal mechanical oxygenation (ECMO), or cardiopulmonary support). 965 C191388 Therapeutic and Supportive Procedures for COVID-19 Stent used C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment A small stainless steel expandable mesh tube, inserted within the lumen of tubular body structures, to help keep it open C50190 Stent Device Stent A device designed to support a tubular structure, especially the small stainless steel expandable mesh tube inserted within an artery. 966 C191388 Therapeutic and Supportive Procedures for COVID-19 Yes C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 967 C191388 Therapeutic and Supportive Procedures for COVID-19 No C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment C49487 No The non-affirmative response to a question. 968 C191388 Therapeutic and Supportive Procedures for COVID-19 Stent type C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment Type of stent used to treat lesion C191496 Type of Stent Used A question about which type of stent was used to treat the lesion. 969 C191388 Therapeutic and Supportive Procedures for COVID-19 Bare-metal C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment Metallic coronary stent without a polymer or antiproliferative drug coating C80464 Bare Metal Stent A vascular metal mesh tube without a coating. 970 C191388 Therapeutic and Supportive Procedures for COVID-19 Drug-eluting C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment Metallic coronary stent with or without a polymer but with an antiproliferative drug coating C80465 Drug Eluting Stent A vascular metal mesh tube coated with medication. The drug coating is intended to lessen the likelihood of restenosis. 971 C191388 Therapeutic and Supportive Procedures for COVID-19 Drug-eluting with bioabsorbable polymer C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment Metallic coronary stent with a bioabsorbable polymer with an antiproliferative drug coating C191544 Bioabsorbable Polymer-Coated Drug Eluting Stent A biodegradable drug-eluting vascular stent that is coated with a polymer that releases an anti-proliferative drug to inhibit intimal growth and prevent restenosis after implantation. The polymer degrades after completion of drug release, leaving an inert metal scaffold in place. 972 C191388 Therapeutic and Supportive Procedures for COVID-19 Bioabsorbable C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment Stent struts composed of bioabsorbable materials also containing an antiproliferative drug C191622 Bioabsorbable Vascular Stent BVS || Bioresorbable Vascular Stent A type of vascular stent that is biodegradable. 973 C191388 Therapeutic and Supportive Procedures for COVID-19 Covered C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment Metallic coronary stent scaffold incorporating fabric or graft material, such as PTFE or polyurethane as a membrane component C191623 Covered Stent A metallic vascular stent encased by a synthetic membrane, often polytetrafluoroethylene or polyurethane, developed to prevent restenosis from proliferation of tissue as may be the case with uncovered stents. 974 C191388 Therapeutic and Supportive Procedures for COVID-19 Multiple types C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment Treatment of several arteries using different stent types C191495 Multiple Stent Types Used A response indicating that arteries were treated for stenosis by using different stent types. 975 C191388 Therapeutic and Supportive Procedures for COVID-19 Other C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment A proper value is applicable but not known. C17649 Other Other or Miscellaneous Different than the one(s) previously specified or mentioned. 976 C191388 Therapeutic and Supportive Procedures for COVID-19 TIMI flow prior to PCI C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment Indicate if the previously treated and stented lesion is being treated for in-stent restenosis. C191498 TIMI Flow prior to PCI Thrombolysis in Myocardial Infarction Flow prior to Percutaneous Coronary Intervention A question about the Thrombolysis in Myocardial Infarction (TIMI) flow grade of the previously treated lesion which is now being treated again for in-stent restenosis. 977 C191388 Therapeutic and Supportive Procedures for COVID-19 TIMI 0 C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment No flow/no perfusion C100040 Thrombolysis in Myocardial Infarction Flow-0 TIMI Flow-0 No perfusion: No antegrade flow beyond the point of occlusion. (www.TIMI.org accessed 21SEP2011) (ACC) 978 C191388 Therapeutic and Supportive Procedures for COVID-19 TIMI 1 C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment Slow penetration without perfusion C100041 Thrombolysis in Myocardial Infarction Flow-1 TIMI Flow-1 Penetration without perfusion: The contrast material passes beyond the area of obstruction, but fails to opacify the entire coronary bed distal to the obstruction for the duration of the cine run. (www.TIMI.org accessed 21SEP2011) (ACC) 979 C191388 Therapeutic and Supportive Procedures for COVID-19 TIMI 2 C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment Partial flow/partial perfusion (>TIMI 1 but <TIMI 3) C100042 Thrombolysis in Myocardial Infarction Flow-2 TIMI Flow-2 Partial reperfusion: The contrast material passes across the obstruction and opacifies the entire coronary bed distal to the obstruction. However, the rate of entry of contrast into the vessel distal to the obstruction and/or its rate of clearance from the distal bed are perceptibly slower than its entry into and/or clearance from comparable areas not perfused by the culprit vessel (e.g., the opposite coronary artery or coronary bed proximal to the obstruction).(www.TIMI.org accessed 21SEP2011) (ACC) 980 C191388 Therapeutic and Supportive Procedures for COVID-19 TIMI 3 C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment Complete and brisk flow/complete perfusion C100043 Thrombolysis in Myocardial Infarction Flow-3 TIMI Flow-3 Complete perfusion: Antegrade flow into the bed distal to the obstruction occurs as promptly as into the bed proximal to the obstruction and clearance of contrast material from the involved bed is as rapid as from an uninvolved bed in the same vessel or the opposite artery. (www.TIMI.org accessed 21SEP2011) (ACC) 981 C191388 Therapeutic and Supportive Procedures for COVID-19 Unknown C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 982 C191388 Therapeutic and Supportive Procedures for COVID-19 TIMI flow after PCI C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment Indicate the postintervention TIMI flow. C191497 TIMI Flow after PCI Thrombolysis in Myocardial Infarction Flow after Percutaneous Coronary Intervention A question about the post-interventional Thrombolysis in Myocardial Infarction (TIMI) flow grade. 983 C191388 Therapeutic and Supportive Procedures for COVID-19 TIMI 0 C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment No flow/no perfusion C100040 Thrombolysis in Myocardial Infarction Flow-0 TIMI Flow-0 No perfusion: No antegrade flow beyond the point of occlusion. (www.TIMI.org accessed 21SEP2011) (ACC) 984 C191388 Therapeutic and Supportive Procedures for COVID-19 TIMI 1 C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment Slow penetration without perfusion C100041 Thrombolysis in Myocardial Infarction Flow-1 TIMI Flow-1 Penetration without perfusion: The contrast material passes beyond the area of obstruction, but fails to opacify the entire coronary bed distal to the obstruction for the duration of the cine run. (www.TIMI.org accessed 21SEP2011) (ACC) 985 C191388 Therapeutic and Supportive Procedures for COVID-19 TIMI 2 C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment Partial flow/partial perfusion (>TIMI 1 but <TIMI 3) C100042 Thrombolysis in Myocardial Infarction Flow-2 TIMI Flow-2 Partial reperfusion: The contrast material passes across the obstruction and opacifies the entire coronary bed distal to the obstruction. However, the rate of entry of contrast into the vessel distal to the obstruction and/or its rate of clearance from the distal bed are perceptibly slower than its entry into and/or clearance from comparable areas not perfused by the culprit vessel (e.g., the opposite coronary artery or coronary bed proximal to the obstruction).(www.TIMI.org accessed 21SEP2011) (ACC) 986 C191388 Therapeutic and Supportive Procedures for COVID-19 TIMI 3 C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment Complete and brisk flow/complete perfusion C100043 Thrombolysis in Myocardial Infarction Flow-3 TIMI Flow-3 Complete perfusion: Antegrade flow into the bed distal to the obstruction occurs as promptly as into the bed proximal to the obstruction and clearance of contrast material from the involved bed is as rapid as from an uninvolved bed in the same vessel or the opposite artery. (www.TIMI.org accessed 21SEP2011) (ACC) 987 C191388 Therapeutic and Supportive Procedures for COVID-19 Unknown C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 988 C191388 Therapeutic and Supportive Procedures for COVID-19 % stenosis prior to PCI C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment Percent diameter stenosis immediately before the treatment of this lesion. Percentage diameter reduction, ranging from 0 to 100, associated with the identified vessels. Percent stenosis at its maximal point is estimated to be the amount of reduction in the diameter of the "normal" reference vessel proximal to the lesion. In instances where multiple lesions are present, enter the single highest percent stenosis noted. C191587 Percent Diameter prior to PCI Percent Stenosis prior to Percutaneous Coronary Intervention The percent diameter stenosis immediately before the treatment of the lesion. 989 C191388 Therapeutic and Supportive Procedures for COVID-19 % stenosis after PCI C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment Percent diameter stenosis after treatment of this lesion. Percentage diameter reduction, ranging from 0 to 100, associated with the identified vessels. Percent stenosis at its maximal point is estimated to be the amount of reduction in the diameter of the "normal" reference vessel proximal to the lesion. In instances where multiple lesions are present, enter the single highest percent stenosis noted. C191586 Percent Stenosis after PCI Percent Stenosis after Percutaneous Coronary Intervention The percent diameter stenosis after the treatment of the lesion. 990 C191388 Therapeutic and Supportive Procedures for COVID-19 Percutaneous arterial access C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment Arterial access site(s) C100056 Arterial Access Site Anatomical location where an artery was accessed for a diagnostic or therapeutic procedure. 991 C191388 Therapeutic and Supportive Procedures for COVID-19 Femoral || Femoral artery C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment The artery of the groin that supplies the lower extremity, including the anterior and anteromedial surfaces of the thigh, whose pulse is palpable below the inguinal ligament, midway between the anterior superior iliac spine and the symphysis pubis. C12715 Femoral Artery An artery that starts within the inguinal region and extends to the lower extremities. 992 C191388 Therapeutic and Supportive Procedures for COVID-19 Brachial || Brachial artery C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment The artery of the upper arm, whose pulse can be palpated on the inner surface of the upper arm between the bodies of the biceps and triceps muscles. C12681 Brachial Artery An artery originating at the axillary artery and branching into the radial and ulnar arteries. 993 C191388 Therapeutic and Supportive Procedures for COVID-19 Radial || Radial artery C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment The artery of the lower arm that supplies muscles of lateral portions of both the anterior and posterior compartment of the forearm, lateral aspect of the wrist, skin of the dorsum hand and proximal portions of digits, and deep muscles of pain whose pulsations can be palpated on the flexor surface of the wrist laterally. C12838 Radial Artery The branch of the brachial artery that passes down the forearm. 994 C191388 Therapeutic and Supportive Procedures for COVID-19 Other C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment A proper value is applicable but not known. C17649 Other Other or Miscellaneous Different than the one(s) previously specified or mentioned. 995 C191388 Therapeutic and Supportive Procedures for COVID-19 Unknown C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 996 C191388 Therapeutic and Supportive Procedures for COVID-19 Thrombectomy for pulmonary embolism C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment Interventional procedure to remove a blood clot from a pulmonary artery in a patient with acute pulmonary embolism C191634 Thrombectomy for Pulmonary Embolism An interventional procedure to remove a blood clot from a pulmonary artery in a patient with acute pulmonary embolism. 997 C191388 Therapeutic and Supportive Procedures for COVID-19 Yes C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 998 C191388 Therapeutic and Supportive Procedures for COVID-19 No C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment C49487 No The non-affirmative response to a question. 999 C191388 Therapeutic and Supportive Procedures for COVID-19 Unknown C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 1000 C191388 Therapeutic and Supportive Procedures for COVID-19 Thrombectomy for stroke C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment Interventional procedure to remove a blood clot from an artery in a patient with acute ischemic stroke C191635 Thrombectomy for Stroke An interventional procedure to remove a blood clot from an artery in a patient with acute ischemic stroke. 1001 C191388 Therapeutic and Supportive Procedures for COVID-19 Yes C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 1002 C191388 Therapeutic and Supportive Procedures for COVID-19 No C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment C49487 No The non-affirmative response to a question. 1003 C191388 Therapeutic and Supportive Procedures for COVID-19 Unknown C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 1004 C191388 Therapeutic and Supportive Procedures for COVID-19 Thrombectomy for peripheral arterial thrombus C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment Interventional procedure to remove a blood clot from a peripheral artery, excluding acute ischemic stroke C191633 Thrombectomy for Peripheral Arterial Thrombus An interventional procedure to remove a blood clot from a peripheral artery, excluding acute ischemic stroke. 1005 C191388 Therapeutic and Supportive Procedures for COVID-19 Yes C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 1006 C191388 Therapeutic and Supportive Procedures for COVID-19 No C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment C49487 No The non-affirmative response to a question. 1007 C191388 Therapeutic and Supportive Procedures for COVID-19 Unknown C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 1008 C191388 Therapeutic and Supportive Procedures for COVID-19 Thrombolysis for pulmonary embolism C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment Treatment to remove a blood clot from a pulmonary artery in a patient with acute ischemic stroke C191636 Thrombolysis for Pulmonary Embolism Medical treatment to break up a blood clot from a pulmonary artery in a patient with acute pulmonary embolism. 1009 C191388 Therapeutic and Supportive Procedures for COVID-19 Yes C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 1010 C191388 Therapeutic and Supportive Procedures for COVID-19 No C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment C49487 No The non-affirmative response to a question. 1011 C191388 Therapeutic and Supportive Procedures for COVID-19 Unknown C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 1012 C191388 Therapeutic and Supportive Procedures for COVID-19 Thrombolysis for stroke C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment Treatment to remove a blood clot from an artery in a patient with acute ischemic stroke C191637 Thrombolysis for Stroke Medical treatment to break up a blood clot from an artery in a patient with acute ischemic stroke. 1013 C191388 Therapeutic and Supportive Procedures for COVID-19 Yes C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 1014 C191388 Therapeutic and Supportive Procedures for COVID-19 No C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment C49487 No The non-affirmative response to a question. 1015 C191388 Therapeutic and Supportive Procedures for COVID-19 Unknown C191400 Invasive Coronary/Vascular/Neurovascular Revascularization Treatment A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 1016 C191389 End-of-Life Management Limitation of resuscitation Any documented order or decision regarding patient request to limit a component of emergency therapy to restore circulation or ventilation (e.g., no intubation, no shocking, no chest compressions) C191445 Limitation of Resuscitation A documented order or decision regarding a patient's request to limit a component of emergency therapy to restore circulation or ventilation (e.g., no intubation, no shocking, no chest compressions). 1017 C191389 End-of-Life Management Yes ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 1018 C191389 End-of-Life Management No C49487 No The non-affirmative response to a question. 1019 C191389 End-of-Life Management Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 1020 C191389 End-of-Life Management DNR Explicit documentation by health care provider or patient indicating that no resuscitative efforts are to be performed in the event of circulatory or respiratory arrest C93313 Do Not Resuscitate Order DNR || Do Not Resuscitate 1021 C191389 End-of-Life Management Yes ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 1022 C191389 End-of-Life Management No C49487 No The non-affirmative response to a question. 1023 C191389 End-of-Life Management Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 1024 C191389 End-of-Life Management Inactivation of ICD defibrillation mode Inactivation of ICD defibrillation mode without plans to reactivate (excludes inactivation for specific surgical procedures) C191444 Inactivation of ICD Defibrillation Mode A documented order or decision to inactivate the ICD defibrillation mode without plans for reactivation (excludes inactivation for specific surgical procedures). 1025 C191389 End-of-Life Management Yes ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 1026 C191389 End-of-Life Management No C49487 No The non-affirmative response to a question. 1027 C191389 End-of-Life Management Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 1028 C191389 End-of-Life Management Advance care planning The process of clarifying goals of care, communicating wishes and goals for medical care in the event of an emergency, and documenting those wishes or plan in an advance directive C191599 Advance Care Planning The process of clarifying the aims of care, communicating wishes and goals for medical care in the event of an emergency, and documenting those wishes or plan in an advance directive. 1029 C191389 End-of-Life Management Yes ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 1030 C191389 End-of-Life Management No C49487 No The non-affirmative response to a question. 1031 C191389 End-of-Life Management Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 1032 C191389 End-of-Life Management Medical order for life-sustaining treatment A written medical order by a physician, advanced practice registered nurse, or physician assistant that records a patient's treatment preferences as to life-sustaining treatment C176984 Physician Orders for Life Sustaining Treatment A medical order form, signed by a medical professional, that outlines a plan for end of life care that reflects both a patient's preferences concerning care at life's end and a physician's judgment based on a medical evaluation. 1033 C191389 End-of-Life Management Yes ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 1034 C191389 End-of-Life Management No C49487 No The non-affirmative response to a question. 1035 C191389 End-of-Life Management Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 1036 C191389 End-of-Life Management Discharge to hospice Discharge to either home hospice or to a facility with hospice care C191585 Discharge to Hospice The disposition of a patient to hospice care. 1037 C191389 End-of-Life Management Yes ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 1038 C191389 End-of-Life Management No C49487 No The non-affirmative response to a question. 1039 C191389 End-of-Life Management Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 1040 C191389 End-of-Life Management Palliative care consultation Consultation with a palliative care provider C191566 Palliative Care Consultation The evaluation of a patient's care with the focus on minimizing their discomfort and maximizing their quality of life rather than curing their disease. 1041 C191389 End-of-Life Management Yes ICD: a battery-powered electrical impulse generator implanted in patients at risk of sudden cardiac death to detect cardiac arrhythmia and correct it by delivering a jolt of electricity. This would include BiV-ICDs. C49488 Yes The affirmative response to a question. 1042 C191389 End-of-Life Management No C49487 No The non-affirmative response to a question. 1043 C191389 End-of-Life Management Unknown A proper value is applicable but not known. C17998 Unknown Not Known || Unknown/Not Stated Not known, observed, recorded; or reported as unknown by the data contributor. 1044