NCIt Code	NCIt Preferred Term	NCIt Definition	GAIA Preferred Term	GAIA Synonym	GAIA Definition	GAIA Subset Code	GAIA Subset Name
C92921	Abdominal Pregnancy	Ectopic pregnancy characterized by the implantation of the embryo in the peritoneal cavity or abdominal organs.	Intra-abdominal Pregnancy		A rare form of an ectopic pregnancy, in which a pregnancy implants into the peritoneal cavity or into the abdominal organs.	C128706	GAIA Antenatal Bleeding Level of Diagnostic Certainty Terminology
C114371	Antepartum Hemorrhage	Excessive blood loss prior to onset of labor.	Antenatal Bleeding		A clinical syndrome that is characterized by bleeding during the second or third trimester of pregnancy. Pathologic etiologies attributable to the pregnant state include placenta previa, morbidly adherent placenta, vasa previa, placental abruption, cesarean scar pregnancy, intra-abdominal pregnancy, and uterine rupture.	C128706	GAIA Antenatal Bleeding Level of Diagnostic Certainty Terminology
C113381	Antepartum Stillbirth	Fetal death greater than or equal to 20 weeks of gestation prior to labor with Apgar scores of 0 at 1 minute, 5 minutes and beyond.	Antepartum Stillbirth		Foetal death occurring during pregnancy and prior to delivery, before the onset of labor. It is usually diagnosed prior to delivery, but may not be diagnosed until after the infant is delivered. The infant is born without signs of life.	C126856	GAIA Stillbirth Level of Diagnostic Certainty Terminology
C25155	Birth	The event of being born.	Delivery		The birth of an offspring, which breathes or shows evidence of life, or is born without signs of life at an estimated gestation of 24 weeks or more (as defined by Preterm Birth guidelines: http:www.brightoncollaboration.org).	C126859	GAIA Postpartum Hemorrhage Level of Diagnostic Certainty Terminology
C128715	Cesarean Scar Pregnancy	An ectopic pregnancy implanted in a previous cesarean (hysterotomy) scar, surrounded by myometrium and connective tissue.	Cesarean Scar Pregnancy		An ectopic pregnancy implanted in a previous cesarean (hysterotomy) scar, surrounded by myometrium and connective tissue.	C128706	GAIA Antenatal Bleeding Level of Diagnostic Certainty Terminology
C113492	Dysfunctional Labor	Uterine contractions (less than 3 in 10 minutes or inadequate strength) that do not result in progressive cervical dilation.	Dysfunctional Labor		Prolongation in the duration of labor, typically during the first stage of labor. Diagnosis of a delay in labor is dependent upon careful monitoring of uterine contraction intensity, duration, and frequency, cervical dilation, and the descent of the fetus through the pelvis.	C128707	GAIA Dysfunctional Labor Level of Diagnostic Certainty Terminology
C34945	Ectopic Pregnancy	An abnormal pregnancy in which the conception is implanted outside the endometrial cavity.	Ectopic Pregnancy		A pregnancy that implants in a location other than the uterine endometrium.	C128705	GAIA Spontaneous Abortion and Ectopic Pregnancy Level of Diagnostic Certainty Terminology
C114936	Extremely Low Birth Weight	Birth weight less than 1000 grams.	Extremely Low Birth Weight			C128701	GAIA Low Birth Weight Level of Diagnostic Certainty Terminology
C114939	Extremely Preterm Infant	A newborn infant less than 28 weeks, 0 days gestational age.	Extremely Preterm Infant		A baby born alive with a gestational age between 28 weeks. (WHO)	C126855	GAIA Preterm Birth Level of Diagnostic Certainty Terminology
C114875	Fetus Small for Gestational Age	A fetus that does not grow beyond the 10th percentile of conventionally accepted weight for gestational age.	Fetal Growth Restriction		A fetus with a sonographic estimation of fetal weight below the tenth percentile for a given gestational age, with increasing specificity for adverse perinatal outcomes below the third percentile.	C128708	GAIA Fetal Growth Restriction Level of Diagnostic Certainty Terminology
C128775	First Trimester Spontaneous Abortion	Pregnancy loss at less than 14 weeks 0 days gestation.	First Trimester Spontaneous Abortion		Pregnancy loss at less than 14 weeks 0 days gestation.	C128705	GAIA Spontaneous Abortion and Ectopic Pregnancy Level of Diagnostic Certainty Terminology
C128915	GAIA Insufficient Evidence for Diagnosis of Fetal Growth Restriction	GAIA Insufficient Evidence for Diagnosis of Fetal Growth Restriction is defined as the absence of an ultrasound for use in the assessment of estimated fetal weight.	Insufficient Evidence for Fetal Growth Restriction		Insufficient Evidence for Fetal Growth Restriction is defined as the absence of an ultrasound for use in the assessment of estimated fetal weight.	C128708	GAIA Fetal Growth Restriction Level of Diagnostic Certainty Terminology
C128756	GAIA Insufficient Evidence for Diagnosis of Gestational Diabetes Mellitus	GAIA Insufficient Evidence for Diagnosis of Gestational Diabetes Mellitus (GDM) is a category of individuals for whom a diagnosis of GDM cannot be made due to one of the following: a) the blood glucose cannot be measured; b) elevated postprandial blood glucose level without confirmatory fasting venous blood or capillary glucose level; c) use of Hemoglobin A1c alone, without a diagnostic oral glucose tolerance test or elevated fasting plasma glucose level; d) clinical and laboratory findings, including glucosuria, fundal height greater than dates, obesity, prior history of GDM, or family history for the diagnosis of gestational diabetes mellitus, without a diagnostic test.	Insufficient Evidence for Gestational Diabetes Mellitus		Insufficient Evidence for Gestational Diabetes Mellitus (GDM) is a category of individuals for whom a diagnosis of GDM cannot be made due to one of the following: a) the blood glucose cannot be measured; b) elevated postprandial blood glucose level without confirmatory fasting venous blood or capillary glucose level; c) use of Hemoglobin A1c alone, without a diagnostic oral glucose tolerance test or elevated fasting plasma glucose level; d) clinical and laboratory findings, including glucosuria, fundal height greater than dates, obesity, prior history of GDM, or family history for the diagnosis of gestational diabetes mellitus, without a diagnostic test.	C128709	GAIA Gestational Diabetes Mellitus Level of Diagnostic Certainty Terminology
C128011	GAIA Insufficient Evidence for Diagnosis of Gestational Hypertension	GAIA Insufficient Evidence for Diagnosis of Gestational Hypertension is defined by two criteria: first, a pregnancy with gestational age greater than or equal to 20 weeks; second, one or more of the following requirements: a) The inability to measure blood pressure; b) The inability to evaluate for proteinuria.	Insufficient Evidence for Gestational Hypertension		Insufficient Evidence for Gestational Hypertension is defined by two criteria: first, a pregnancy with gestational age greater than or equal to 20 weeks; second, one or more of the following requirements: a) The inability to measure blood pressure; b) The inability to evaluate for proteinuria.	C126860	GAIA Preeclampsia Level of Diagnostic Certainty Terminology
C128005	GAIA Insufficient Evidence for Diagnosis of Preeclampsia	GAIA Insufficient Evidence for Diagnosis of Preeclampsia is defined as a pregnancy with gestational age greater than or equal to 20 weeks and either a) The inability to measure blood pressure OR b) The inability to evaluate for proteinuria.	Insufficient Evidence for Preeclampsia		Insufficient Evidence for Preeclampsia is defined as a pregnancy with gestational age greater than or equal to 20 weeks and either a) The inability to measure blood pressure OR b) The inability to evaluate for proteinuria.	C126860	GAIA Preeclampsia Level of Diagnostic Certainty Terminology
C128008	GAIA Insufficient Evidence for Diagnosis of Preeclampsia with Severe Features	GAIA Insufficient Evidence for Diagnosis of Preeclampsia with Severe Features is a pregnancy with a gestational age greater than or equal to 20 weeks and the inability to measure blood pressure.	Insufficient Evidence for Preeclampsia with Severe Features		Insufficient Evidence for Preeclampsia with Severe Features is a pregnancy with a gestational age greater than or equal to 20 weeks and the inability to measure blood pressure.	C126860	GAIA Preeclampsia Level of Diagnostic Certainty Terminology
C128018	GAIA Level 1 Antepartum Stillbirth	GAIA Level 1 Antepartum Stillbirth is defined by four criteria: first, one or more of the following three requirements must be met: a) Prenatal ultrasound examination (e.g. basic ultrasound or special ultrasound with Doppler) documenting an absence of fetal cardiac activity or movement before the onset of labor; b) Radiology findings consistent with intrauterine fetal death; c) Delivery of an infant with no of signs of life at birth, including no spontaneous movements, no umbilical cord pulse, no heartbeat, no respirations, and Apgar scores of 0 at both 1 and 5 minutes. The determination of the absence of signs of life is made by physical examination after delivery, with or without electronic monitoring of heart rate, respiratory rate, and pulse oximetry; second, the following three criteria must be met: a) Maternal report of the absence of fetal movement for 24 hours or more; b) Maternal physical examination confirming the absence of fetal movement; c) Auscultation for fetal heart tones using electronic devices (e.g. handheld Doppler or fetal heart rate monitor) OR non-electronic devices (e.g. stethoscope, fetoscope, or Pinard horn) that documents the absence of a fetal heartbeat; third, one of the following two requirements must be met: a) Attended delivery, followed by a post-delivery physical examination of the fetus by an obstetrician, a neonatologist, a pediatrician, a maternal-fetal medicine specialist, or a pathologist that is consistent with antepartum death. In a setting where access to a specialist is not feasible, diagnosis by a health care provider trained or experienced to make the diagnosis is acceptable (e.g. general practice physician, mid-wife, nurse practitioner, a physician's assistant, or other qualified trained practitioner); OR b) fetal/placental pathology report that is consistent with antepartum death; fourth, gestational age within the pre-defined range for selected stillbirth definition, as assessed by maternal and/or fetal parameters (level 1 in GA assessment algorithm).	Level 1 Antepartum Stillbirth		Level 1 Antepartum Stillbirth is defined by four criteria: first, one or more of the following three requirements must be met: a) Prenatal ultrasound examination (e.g. basic ultrasound or special ultrasound with Doppler) documenting an absence of fetal cardiac activity or movement before the onset of labor; b) Radiology findings consistent with intrauterine fetal death; c) Delivery of an infant with no of signs of life at birth, including no spontaneous movements, no umbilical cord pulse, no heartbeat, no respirations, and Apgar scores of 0 at both 1 and 5 minutes. The determination of the absence of signs of life is made by physical examination after delivery, with or without electronic monitoring of heart rate, respiratory rate, and pulse oximetry; second, the following three criteria must be met: a) Maternal report of the absence of fetal movement for 24 hours or more; b) Maternal physical examination confirming the absence of fetal movement; c) Auscultation for fetal heart tones using electronic devices (e.g. handheld Doppler or fetal heart rate monitor) OR non-electronic devices (e.g. stethoscope, fetoscope, or Pinard horn) that documents the absence of a fetal heartbeat; third, one of the following two requirements must be met: a) Attended delivery, followed by a post-delivery physical examination of the fetus by an obstetrician, a neonatologist, a paediatrician, a maternal-fetal medicine specialist, or a pathologist that is consistent with antepartum death. In a setting where access to a specialist is not feasible, diagnosis by a health care provider trained or experienced to make the diagnosis is acceptable (e.g. general practice physician, mid-wife, nurse practitioner, a physician's assistant, or other qualified trained practitioner); OR b) fetal/placental pathology report that is consistent with antepartum death; fourth, gestational age within the pre-defined range for selected stillbirth definition, as assessed by maternal and/or fetal parameters (level 1 in GA assessment algorithm).	C126856	GAIA Stillbirth Level of Diagnostic Certainty Terminology
C128013	GAIA Level 1 Assessment of Gestational Age	GAIA Level 1 Assessment of Gestational Age is defined by the presence of at least one of the following criteria: a) the last menstrual period (LMP) or intrauterine insemination (IUI) date or embryo transfer (ET) date with confirmatory first trimester scan (less than or equal to 13 6/7 weeks); OR b) first trimester scan (less than or equal to 13 6/7 weeks).	Level 1 Assessment of Prematurity and Gestational Age		Level 1 Assessment of Gestational Age is defined by the presence of at least one of the following criteria: a) the last menstrual period (LMP) or intrauterine insemination (IUI) date or embryo transfer (ET) date with confirmatory first trimester scan (less than or equal to 13 6/7 weeks); OR b) first trimester scan (less than or equal to 13 6/7 weeks).	C126855	GAIA Preterm Birth Level of Diagnostic Certainty Terminology
C127953	GAIA Level 1 Assessment of Insufficient Cervix	GAIA Level 1 Assessment of Insufficient Cervix is defined by two criteria: first, the following three requirements must all be met: a) Presentation between 16 and 23 6/7 weeks gestation; b) Advanced cervical dilation greater than two centimeters, resulting in either treatment with a cerclage (cervical stitch) or with preterm delivery; c) Less than or equal to four contractions per hour as documented by a tocodynometer, meaning the patient is not in preterm labor; second, dilation of the internal cervical os greater than two centimeters as determined by transvaginal ultrasound or digital examination.	Level 1 Assessment of Insufficient Cervix		Level 1 Assessment of Insufficient Cervix is defined by two criteria: first, the following three requirements must all be met: a) Presentation between 16 and 23 6/7 weeks gestation; b) Advanced cervical dilation greater than two centimeters, resulting in either treatment with a cerclage (cervical stitch) or with preterm delivery; c) Less than or equal to four contractions per hour as documented by a tocodynometer, meaning the patient is not in preterm labor; second, dilation of the internal cervical os greater than two centimeters as determined by transvaginal ultrasound or digital examination.	C126861	GAIA Pathways to Preterm Birth Level of Diagnostic Certainty Terminology
C127944	GAIA Level 1 Assessment of Premature Preterm Rupture of Membranes	GAIA Level 1 Assessment of Premature Preterm Rupture of Membranes is defined by five criteria: first, presentation between 24 0/7 and 36 6/7 weeks gestation with a clinical history of rupture of membranes, the fluid from which may be any color, including clear, blood-tinged, meconium-tinged (fetal stool), or purulent-tinged (yellowish, suggesting infection); second, the patient is determined to not be in preterm labor (having less than or equal to 4 contractions per hour documented clinically or on tocodynometer, with less than 2cm cervical dilation); third, visible leakage of fluid on vaginal speculum exam; fourth, one of the two following requirements must be met: a) Visible arborization (ferning) on microscopy of amniotic fluid; OR b) Ultrasound with oligohydramnios (amniotic fluid index (AFI) less than 5, or maximum vertical pocket (MVP) less than 2); fifth, documentation of the membrane rupture by one of the following diagnostic tests: a) Positive intra-amniotic dye-injection method; b) Positive result on amniotic fluid alpha-fetoprotein test kit; c) Amniotic fluid pH measurement (nitrazine paper test); d) Amniotic fluid placental alpha macroglobulin-1 protein assay (PAMG-1) test (AmniSure test); e) Amniotic fluid insulin-like growth factor binding protein (IGFBP-1) test (Actim PROM test).	Level 1 Assessment of Premature Preterm Rupture of Membranes		Level 1 Assessment of Premature Preterm Rupture of Membranes is defined by five criteria: first, presentation between 24 0/7 and 36 6/7 weeks gestation with a clinical history of rupture of membranes, the fluid from which may be any colour, including clear, blood-tinged, meconium-tinged (fetal stool), or purulent-tinged (yellowish, suggesting infection); second, the patient is determined to not be in preterm labor (having less than or equal to 4 contractions per hour documented clinically or on tocodynometer, with less than 2cm cervical dilation); third, visible leakage of fluid on vaginal speculum exam; fourth, one of the two following requirements must be met: a) Visible arborization (ferning) on microscopy of amniotic fluid; OR b) Ultrasound with oligohydramnios (amniotic fluid index (AFI) less than 5, or maximum vertical pocket (MVP) less than 2); fifth, documentation of the membrane rupture by one of the following diagnostic tests: a) Positive intra-amniotic dye-injection method; b) Positive result on amniotic fluid alpha-fetoprotein test kit; c) Amniotic fluid pH measurement (nitrazine paper test); d) Amniotic fluid placental alpha macroglobulin-1 protein assay (PAMG-1) test (AmniSure test); e) Amniotic fluid insulin-like growth factor binding protein (IGFBP-1) test (Actim PROM test).	C126861	GAIA Pathways to Preterm Birth Level of Diagnostic Certainty Terminology
C127947	GAIA Level 1 Assessment of Preterm Labor	GAIA Level 1 Assessment of Preterm Labor is defined by three criteria: first, confirmed delivery of a fetus between 24 0/7 and 36 6/7 weeks gestation; second, greater than four uterine contractions per hour as determined by a tocodynometer OR transvaginal ultrasound during a two hour period; third, documented change in length or dilation of the cervix by physical examination, with clinical criteria obtained by digital examination, including: a) Cervical dilation of two centimeters or more at the internal os; b) Cervical length of one centimeter or less; c) greater than or equal to 50% effacement of the cervix.	Level 1 Assessment of Preterm Labor		Level 1 Assessment of Preterm Labor is defined by three criteria: first, confirmed delivery of a fetus between 24 0/7 and 36 6/7 weeks gestation; second, greater than four uterine contractions per hour as determined by a tocodynometer OR transvaginal ultrasound during a two hour period; third, documented change in length or dilation of the cervix by physical examination, with clinical criteria obtained by digital examination, including: a) Cervical dilation of two centimeters or more at the internal os; b) Cervical length of one centimeter or less; c) greater than or equal to 50% effacement of the cervix.	C126861	GAIA Pathways to Preterm Birth Level of Diagnostic Certainty Terminology
C127950	GAIA Level 1 Assessment of Provider Initiated Preterm Delivery	GAIA Level 1 Assessment of Provider-Initiated Preterm Delivery is defined by three criteria: first, the patient is determined to be between 24 0/7 and 36 6/7 weeks gestation; second, documentation in the healthcare record as noted by the delivering provider of the absence of any signs or symptoms of spontaneous onset of preterm labor; third, additional documentation of the need to induce labor or to perform a cesarean delivery, resulting in a preterm delivery.	Level 1 Assessment of Provider-Initiated Preterm Delivery		Level 1 Assessment of Provider-Initiated Preterm Delivery is defined by three criteria: first, the patient is determined to be between 24 0/7 and 36 6/7 weeks gestation; second, documentation in the healthcare record as noted by the delivering provider of the absence of any signs or symptoms of spontaneous onset of preterm labor; third, additional documentation of the need to induce labor or to perform a cesarean delivery, resulting in a preterm delivery.	C126861	GAIA Pathways to Preterm Birth Level of Diagnostic Certainty Terminology
C128750	GAIA Level 1 Cesarean Scar Pregnancy	GAIA Level 1 Cesarean Scar Pregnancy is defined by a transvaginal ultrasound that demonstrates the following five findings: first, an empty uterine cavity; second, an empty cervical canal, without contact with the gestational sac; third, the presence of a gestational sac, with or without a fetal pole, with or without cardiac activity, in the anterior uterine segment adjacent to the cesarean scar; fourth, an absence of or a defect in the myometrium between the bladder and the gestational sac; fifth, a well-perfused gestational sac as demonstrated by Doppler ultrasound (to differentiate from an expulsing, avascular gestational sac). Alternatively, Level 1 may be defined as a hysterectomy specimen with evidence of a pregnancy implanted into the cesarean scar.	Level 1 Cesarean Scar Pregnancy		Level 1 Cesarean Scar Pregnancy is defined by a transvaginal ultrasound that demonstrates the following five findings: first, an empty uterine cavity; second, an empty cervical canal, without contact with the gestational sac; third, the presence of a gestational sac, with or without a fetal pole, with or without cardiac activity, in the anterior uterine segment adjacent to the cesarean scar; fourth, an absence of or a defect in the myometrium between the bladder and the gestational sac; fifth, a well-perfused gestational sac as demonstrated by Doppler ultrasound (to differentiate from an expulsing, avascular gestational sac). Alternatively, Level 1 may be defined as a hysterectomy specimen with evidence of a pregnancy implanted into the cesarean scar.	C128706	GAIA Antenatal Bleeding Level of Diagnostic Certainty Terminology
C128717	GAIA Level 1 Dysfunctional First Stage of Labor	GAIA Level 1 Dysfunctional First Stage of Labor is defined by progress of less than 0.5 cm of cervical dilation per hour, for at least 4 hours, in women with established labor (i.e. have regular contractions and cervical dilation of at least 4 cm) and with confirmed ruptured membranes.	Level 1 Dysfunctional First Stage of Labor		Level 1 Dysfunctional First Stage of Labor is defined by progress of less than 0.5 cm of cervical dilation per hour, for at least 4 hours, in women with established labor (i.e. have regular contractions and cervical dilation of at least 4 cm) and with confirmed ruptured membranes.	C128707	GAIA Dysfunctional Labor Level of Diagnostic Certainty Terminology
C128719	GAIA Level 1 Dysfunctional Second Stage of Labor	GAIA Level 1 Dysfunctional Second Stage of Labor is defined by three criteria. For nulliparous women: first, full dilation of the cervix (10 cm dilated, or no palpable cervix around the presenting part of the fetus); second, the onset of the active stage of labor (active maternal effort (i.e. pushing) or visible baby); third, at least one of the following requirements must be met: a) Greater than 2 hours of pushing; OR b) The use of an instrument (forceps or vacuum/ventouse) for the indication of dystocia; OR c) Cesarean delivery for the indication of dystocia. For multiparous women: first, full dilation of the cervix (10 cm dilated, or no palpable cervix around the presenting part of the fetus); second, the onset of the active stage of labor (active maternal effort (i.e. pushing) or visible baby); third, at least one of the following requirements must be met: a) Greater than 1 hour of pushing; OR b) The use of an instrument (forceps or vacuum/ventouse) for the indication of dystocia; OR c) Cesarean delivery for the indication of dystocia.	Level 1 Dysfunctional Second Stage of Labor		Level 1 Dysfunctional Second Stage of Labor is defined by three criteria. For nulliparous women: first, full dilation of the cervix (10 cm dilated, or no palpable cervix around the presenting part of the fetus); second, the onset of the active stage of labor (active maternal effort (i.e. pushing) or visible baby); third, at least one of the following requirements must be met: a) Greater than 2 hours of pushing; OR b) The use of an instrument (forceps or vacuum/ventouse) for the indication of dystocia; OR c) Cesarean delivery for the indication of dystocia. For multiparous women: first, full dilation of the cervix (10 cm dilated, or no palpable cervix around the presenting part of the fetus); second, the onset of the active stage of labor (active maternal effort (i.e. pushing) or visible baby); third, at least one of the following requirements must be met: a) Greater than 1 hour of pushing; OR b) The use of an instrument (forceps or vacuum/ventouse) for the indication of dystocia; OR c) Cesarean delivery for the indication of dystocia.	C128707	GAIA Dysfunctional Labor Level of Diagnostic Certainty Terminology
C128710	GAIA Level 1 Ectopic Pregnancy	GAIA Level 1 Ectopic Pregnancy is defined by either of the following two criteria: first, the following three requirements must be met: a) Gestational age is within the pre-defined range for the selected ectopic pregnancy definition as assessed by maternal and/or fetal parameters (Level 1-2) (Brighton Preterm Birth Gestational Age algorithm; b) B-HCG serum blood test greater than 2000 mIU/ml; c) Transvaginal ultrasound showing no intrauterine pregnancy; OR second, the following two criteria must be met: a) Gestational age is within the pre-defined range for the selected ectopic pregnancy definition as assessed by maternal and/or fetal parameters (Level 1-2) (Brighton Preterm Birth Gestational Age algorithm; b) Transvaginal ultrasound showing extrauterine pregnancy OR no products of conception found on endometrial curettage after dilation and curettage procedure.	Level 1 Ectopic Pregnancy		Level 1 Ectopic Pregnancy is defined by either of the following two criteria: first, the following three requirements must be met: a) Gestational age is within the pre-defined range for the selected ectopic pregnancy definition as assessed by maternal and/or fetal parameters (Level 1-2) (Brighton Preterm Birth Gestational Age algorithm; b) B-HCG serum blood test greater than 2000 mIU/ml; c) Transvaginal ultrasound showing no intrauterine pregnancy; OR second, the following two criteria must be met: a) Gestational age is within the pre-defined range for the selected ectopic pregnancy definition as assessed by maternal and/or fetal parameters (Level 1-2) (Brighton Preterm Birth Gestational Age algorithm; b) Transvaginal ultrasound showing extrauterine pregnancy OR no products of conception found on endometrial curettage after dilation and curettage procedure.	C128705	GAIA Spontaneous Abortion and Ectopic Pregnancy Level of Diagnostic Certainty Terminology
C128770	GAIA Level 1 Failure to Thrive	GAIA Level 1 Failure to Thrive is defined by four criteria: first, the infant's age is determined by a documented birth date; second, weights are obtained using an electronic scale; third, a minimum of two documented weights measured at least four weeks apart; fourth, the weight for age deceleration must pass through at least two centile spaces on a growth chart. Additionally, the following information applies to this term: a. Age: This case definition is limited to infants up to 12 months of age. b. Weight and Length: Weight should be documented on the appropriate growth chart at the time of assessment. A fall through 2 centile spaces may be demonstrated at any point in the first 12 months of life, using any two weights as long as they are taken at least 4 weeks apart. Details of use of the weight balances allowable under this case definition and use of the Infantometer for length assessment are in Appendix A. c. Growth charts: For infants born at 37 weeks gestation or above, the WHO growth charts should be applied. When using weight for age use the growth chart most accurate for the infants age. The birth to 6 months age range should be used where data is available for this range only, the birth to 2 years chart should be used where data is available beyond 6 months of life. When using weight for length, use the chart for birth to 2 years. For infants born less than 37 completed weeks gestation, the Intergrowth charts for postnatal growth standards in preterm infant should be used. All infants should be plotted on their respective growth chart using their corrected age. Links to relevant growth charts can be found in Appendix A (www.gaia-consortium.net).	Level 1 Failure to Thrive		Level 1 Failure to Thrive is defined by four criteria: first, the infant's age is determined by a documented birth date; second, weights are obtained using an electronic scale; third, a minimum of two documented weights measured at least four weeks apart; fourth, the weight for age deceleration must pass through at least two centile spaces on a growth chart. Additionally, the following information applies to this term: a. Age: This case definition is limited to infants up to 12 months of age. b. Weight and Length: Weight should be documented on the appropriate growth chart at the time of assessment. A fall through 2 centile spaces may be demonstrated at any point in the first 12 months of life, using any two weights as long as they are taken at least 4 weeks apart. Details of use of the weight balances allowable under this case definition and use of the Infantometer for length assessment are in Appendix A. c. Growth charts: For infants born at 37 weeks gestation or above, the WHO growth charts should be applied. When using weight for age use the growth chart most accurate for the infants age. The birth to 6 months age range should be used where data is available for this range only, the birth to 2 years chart should be used where data is available beyond 6 months of life. When using weight for length, use the chart for birth to 2 years. For infants born less than 37 completed weeks gestation, the Intergrowth charts for postnatal growth standards in preterm infant should be used. All infants should be plotted on their respective growth chart using their corrected age. Links to relevant growth charts can be found in Appendix A (www.gaia-consortium.net).	C128704	GAIA Failure to Thrive Level of Diagnostic Certainty Terminology
C128776	GAIA Level 1 First Trimester Spontaneous Abortion	GAIA Level 1 First Trimester Spontaneous Abortion is defined by two criteria: first, at least one of the following three requirements must be met: a) Crown-rump length greater than or equal to 7 mm and no visible heartbeat on transvaginal ultrasound; OR b) Crown-rump length greater than or equal to 15 mm and no visible heartbeat on abdominal ultrasound; OR c) Ultrasound examination demonstrating mean gestational sac diameter greater than or equal to 25 mm and no visible embryo or yolk sac; second, at least one of the following three requirements must be met: a) A second transvaginal ultrasound performed greater than or equal to 7 days later (or 14 days later if transabdominal) confirming the diagnosis of a non-viable pregnancy; OR b) The absence of an embryo with heartbeat 2 weeks or more after a transabdominal scan that initially showed a gestational sac without a yolk sac; OR c) The absence of an embryo with a heartbeat 11 days or more after a transvaginal scan that initially showed a gestational sac with a yolk sac. Alternatively, GAIA Level 1 First Trimester Spontaneous Abortion can be defined by the following two criteria: first, the gestational age is within the pre-defined range for the selected abortion definition as assessed by maternal and/or fetal parameters ( Level 1-2) (using the Brighton Preterm Birth Gestational Age algorithm); second, at least one of the following four requirements must be met: a) Positive urine or blood pregnancy test that becomes negative after 7 days; OR b) Products of conception found on histopathological evaluation of pregnancy tissue; OR c) Ultrasound examination demonstrating an empty uterine cavity in a woman who had clear evidence of intrauterine pregnancy on previous ultrasound examination; OR d) Vaginal bleeding, external cervical os open or closed, with visible expulsion of pregnancy tissues/products of conception.	Level 1 First Trimester Spontaneous Abortion		Level 1 First Trimester Spontaneous Abortion is defined by two criteria: first, at least one of the following three requirements must be met: a) Crown-rump length greater than or equal to 7 mm and no visible heartbeat on transvaginal ultrasound; OR b) Crown-rump length greater than or equal to 15 mm and no visible heartbeat on abdominal ultrasound; OR c) Ultrasound examination demonstrating mean gestational sac diameter greater than or equal to 25 mm and no visible embryo or yolk sac; second, at least one of the following three requirements must be met: a) A second transvaginal ultrasound performed greater than or equal to 7 days later (or 14 days later if transabdominal) confirming the diagnosis of a non-viable pregnancy; OR b) The absence of an embryo with heartbeat 2 weeks or more after a transabdominal scan that initially showed a gestational sac without a yolk sac; OR c) The absence of an embryo with a heartbeat 11 days or more after a transvaginal scan that initially showed a gestational sac with a yolk sac. Alternatively, Level 1 First Trimester Spontaneous Abortion can be defined by the following two criteria: first, the gestational age is within the pre-defined range for the selected abortion definition as assessed by maternal and/or fetal parameters ( Level 1-2) (using the Brighton Preterm Birth Gestational Age algorithm); second, at least one of the following four requirements must be met: a) Positive urine or blood pregnancy test that becomes negative after 7 days; OR b) Products of conception found on histopathological evaluation of pregnancy tissue; OR c) Ultrasound examination demonstrating an empty uterine cavity in a woman who had clear evidence of intrauterine pregnancy on previous ultrasound examination; OR d) Vaginal bleeding, external cervical os open or closed, with visible expulsion of pregnancy tissues/products of conception.	C128705	GAIA Spontaneous Abortion and Ectopic Pregnancy Level of Diagnostic Certainty Terminology
C128753	GAIA Level 1 Gestational Diabetes Mellitus	GAIA Level 1 Gestational Diabetes Mellitus is defined by three criteria: first, at least one of the following requirements must be met: a) absence of pre-gestational diabetes [pre-gestational diabetes is defined as a) previous diagnosis of diabetes while not pregnant OR b) first trimester hemoglobin A1c level of greater than or equal to 6.5% (47.5 mmol/mol) OR c) first trimester fasting blood glucose greater than or equal to 126 mg/dL (7 mmol/L)]; second, gestational age with level 1 or level 2 certainty, using the GAIA definition for gestational age; third, a diagnosis of gestational diabetes as determined by a positive result from an international standard oral glucose tolerance test using venous blood samples.	Level 1 Gestational Diabetes Mellitus		Level 1 Gestational Diabetes Mellitus is defined by three criteria: first, at least one of the following requirements must be met: a) absence of pre-gestational diabetes [pre-gestational diabetes is defined as a) previous diagnosis of diabetes while not pregnant OR b) first trimester hemoglobin A1c level of greater than or equal to 6.5% (47.5 mmol/mol) OR c) first trimester fasting blood glucose greater than or equal to 126 mg/dL (7 mmol/L)]; second, gestational age with level 1 or level 2 certainty, using the GAIA definition for gestational age; third, a diagnosis of gestational diabetes as determined by a positive result from an international standard oral glucose tolerance test using venous blood samples.	C128709	GAIA Gestational Diabetes Mellitus Level of Diagnostic Certainty Terminology
C128009	GAIA Level 1 Gestational Hypertension	GAIA Level 1 Gestational Hypertension is defined by four criteria: first, the gestational age of the pregnancy must be greater than or equal to 20 weeks; second, a diagnosis of new onset maternal hypertension (systolic blood pressure greater than or equal to 140mmHg and/or diastolic blood pressure greater than or equal to 90mmHg) that is sustained on two measurements over a minimum of one hour; third, the absence of any severe features (see preeclampsia with severe features category); fourth, the absence of proteinuria (as defined by 24 hour urine collection less than 300 mg, and spot protein:creatinine ratio less than 0.3).	Level 1 Gestational Hypertension		Level 1 Gestational Hypertension is defined by four criteria: first, the gestational age of the pregnancy must be greater than or equal to 20 weeks; second, a diagnosis of new onset maternal hypertension (systolic blood pressure greater than or equal to 140mmHg and/or diastolic blood pressure greater than or equal to 90mmHg) that is sustained on two measurements over a minimum of one hour; third, the absence of any severe features (see preeclampsia with severe features category); fourth, the absence of proteinuria (as defined by 24 hour urine collection less than 300 mg, and spot protein:creatinine ratio less than 0.3).	C126860	GAIA Preeclampsia Level of Diagnostic Certainty Terminology
C128751	GAIA Level 1 Intra-abdominal Pregnancy	GAIA Level 1 Intra-abdominal Pregnancy is defined by the discovery of a fetus within the abdominal cavity during laparotomy, without evidence of uterine rupture, and with placentation not within the uterine cavity.	Level 1 Intra-abdominal Pregnancy		Level 1 Intra-abdominal Pregnancy is defined by the discovery of a fetus within the abdominal cavity during laparotomy, without evidence of uterine rupture, and with placentation not within the uterine cavity.	C128706	GAIA Antenatal Bleeding Level of Diagnostic Certainty Terminology
C128022	GAIA Level 1 Intrapartum Stillbirth	GAIA Level 1 Intrapartum Stillbirth is defined by four criteria: first, delivery of an infant with no of signs of life at birth, including the following: no spontaneous movements, no umbilical cord pulse, no heartbeat, no respirations, and an Apgar score of 0 at both 1 and 5 minutes. Determination of the absence of signs of life is made by physical examination after delivery, with or without electronic monitoring of heart rate, respiratory rate, and pulse oximetry; second, evidence of a live fetus prior to the onset of labor (confirmed by documentation of fetal movement and of fetal heart tones by ultrasound prior to onset of labor). NOTE: In the absence of evidence of a live fetus prior to the onset of labor, the fetal death should be reported as a stillbirth or an antepartum stillbirth; third, attended delivery followed by post-delivery physical examination by an obstetrician, a neonatologist, a pediatrician, a maternal-fetal medicine specialist, or a pathologist that is consistent with intrapartum death. In a setting where access to a specialist is not feasible, diagnosis by a health care provider trained or experienced to make the diagnosis is acceptable (e.g. general practice physician, mid-wife, or other qualified trained practitioner); fourth, gestational age within the pre-defined range for selected stillbirth definition as assessed by maternal and/or fetal-neonatal parameters (level 1 in GA assessment algorithm).	Level 1 Intrapartum Stillbirth		Level 1 Intrapartum Stillbirth is defined by four criteria: first, delivery of an infant with no of signs of life at birth, including the following: no spontaneous movements, no umbilical cord pulse, no heartbeat, no respirations, and an Apgar score of 0 at both 1 and 5 minutes. Determination of the absence of signs of life is made by physical examination after delivery, with or without electronic monitoring of heart rate, respiratory rate, and pulse oximetry; second, evidence of a live fetus prior to the onset of labor (confirmed by documentation of fetal movement and of fetal heart tones by ultrasound prior to onset of labor). NOTE: In the absence of evidence of a live fetus prior to the onset of labor, the fetal death should be reported as a stillbirth or an antepartum stillbirth; third, attended delivery followed by post-delivery physical examination by an obstetrician, a neonatologist, a paediatrician, a maternal-fetal medicine specialist, or a pathologist that is consistent with intrapartum death. In a setting where access to a specialist is not feasible, diagnosis by a health care provider trained or experienced to make the diagnosis is acceptable (e.g. general practice physician, mid-wife, or other qualified trained practitioner); fourth, gestational age within the pre-defined range for selected stillbirth definition as assessed by maternal and/or fetal-neonatal parameters (level 1 in GA assessment algorithm).	C126856	GAIA Stillbirth Level of Diagnostic Certainty Terminology
C128725	GAIA Level 1 Low Birth Weight	GAIA Level 1 Low Birth Weight is defined by one of the two following criteria: first, a newborn infant is weighed within 24 hours of birth; an electronic scale that is graduated to 10 grams is used; the scale is calibrated at least once a year; the scale is placed on level, hard surface; the scale is tared to zero grams; AND the birth weight recorded is less than 2500 grams; OR second, a birth weight is recorded as less than 2500 grams as assessed per the health care facility's standard operating procedure, which fulfills criteria 1 to 5 of diagnostic level of certainty one.	Level 1 Low Birth Weight		Level 1 Low Birth Weight is defined by one of the two following criteria: first, a newborn infant is weighed within 24 hours of birth; an electronic scale that is graduated to 10 grams is used; the scale is calibrated at least once a year; the scale is placed on level, hard surface; the scale is tared to zero grams; AND the birth weight recorded is less than 2500 grams; OR second, a birth weight is recorded as less than 2500 grams as assessed per the health care facility's standard operating procedure, which fulfills criteria 1 to 5 of diagnostic level of certainty one.	C128701	GAIA Low Birth Weight Level of Diagnostic Certainty Terminology
C127957	GAIA Level 1 Major External Structural Defect	GAIA Level 1 Major External Structural Defect is defined by four criteria: first, the defects are of a prenatal origin; second, at least one of the following requirements must be met: a) Alterations in the external anatomy that are present and visible at the time of live birth, and that persist beyond the immediate peripartum period unless surgically repaired OR b) Alterations in the external anatomy that are present and visible in a stillbirth or in the products of conception of a spontaneous or therapeutic abortion; third, the defect(s) affect (or have the propensity to affect) the health, survival, or physical or cognitive functioning of the individual; fourth, there must be documented confirmation of a diagnosis made by a clinician who is both experienced in diagnosing congenital anomalies and who has the highest level of morphology training for the specific setting.	Level 1 Major External Structural Defect		Level 1 Major External Structural Defect is defined by four criteria: first, the defects are of a prenatal origin; second, at least one of the following requirements must be met: a) Alterations in the external anatomy that are present and visible at the time of live birth, and that persist beyond the immediate peripartum period unless surgically repaired OR b) Alterations in the external anatomy that are present and visible in a stillbirth or in the products of conception of a spontaneous or therapeutic abortion; third, the defect(s) affect (or have the propensity to affect) the health, survival, or physical or cognitive functioning of the individual; fourth, there must be documented confirmation of a diagnosis made by a clinician who is both experienced in diagnosing congenital anomalies and who has the highest level of morphology training for the specific setting.	C126852	GAIA Major Congenital Anomalies Level of Diagnostic Certainty Terminology
C127965	GAIA Level 1 Major Functional Defect	GAIA Level 1 Major Functional Defect is defined by two criteria. first, at least one of the following requirements must be met: a) For live births, there must be alterations in functioning of one or more organs or body parts that are not due to a structural defect, that are present at the time of birth (or propensity to develop alteration present at live birth), and that persist beyond the immediate peripartum period unless treated through gene therapy or stem cell transplantation; OR b) For stillbirths or for spontaneous or therapeutic abortions, there must be alterations in the function of one or more organs or body parts that are not due to a structural defect; second, there must be confirmation of the defect(s) by definitive diagnostic study.	Level 1 Major Functional Defect		Level 1 Major Functional Defect is defined by two criteria. first, at least one of the following requirements must be met: a) For live births, there must be alterations in functioning of one or more organs or body parts that are not due to a structural defect, that are present at the time of birth (or propensity to develop alteration present at live birth), and that persist beyond the immediate peripartum period unless treated through gene therapy or stem cell transplantation; OR b) For stillbirths or for spontaneous or therapeutic abortions, there must be alterations in the function of one or more organs or body parts that are not due to a structural defect; second, there must be confirmation of the defect(s) by definitive diagnostic study.	C126852	GAIA Major Congenital Anomalies Level of Diagnostic Certainty Terminology
C127961	GAIA Level 1 Major Internal Structural Defect	GAIA Level 1 Major Internal Structural Defect is defined by three criteria: first, the defects are prenatal in origin; second, the defect(s) affect (or have the propensity to affect) the health, survival, or physical or cognitive functioning of the individual; third, one of the following requirements must be met: a) For a live birth, alterations in the internal anatomy must be present at the time of live birth, must persist beyond the immediate peripartum period unless surgically repaired, and require confirmation of the diagnosis by definitive imaging study or intraoperative diagnosis; OR b) For a stillbirth, or for a spontaneous or therapeutic abortion, alterations in the internal anatomy must be detected during an autopsy, which are subsequently confirmed by documentation by a pathologist or other relevant subspecialist.	Level 1 Major Internal Structural Defect		Level 1 Major Internal Structural Defect is defined by three criteria: first, the defects are prenatal in origin; second, the defect(s) affect (or have the propensity to affect) the health, survival, or physical or cognitive functioning of the individual; third, one of the following requirements must be met: a) For a live birth, alterations in the internal anatomy must be present at the time of live birth, must persist beyond the immediate peripartum period unless surgically repaired, and require confirmation of the diagnosis by definitive imaging study or intraoperative diagnosis; OR b) For a stillbirth, or for a spontaneous or therapeutic abortion, alterations in the internal anatomy must be detected during an autopsy, which are subsequently confirmed by documentation by a pathologist or other relevant subspecialist.	C126852	GAIA Major Congenital Anomalies Level of Diagnostic Certainty Terminology
C127997	GAIA Level 1 Maternal Death	GAIA Level 1 Maternal Death is defined by three criteria: first, diagnosis of a pregnancy as established by any one of the following documented requirements: a) Ultrasound examination; b) Fetal heart tones; c) Positive serum or urine human chorionic gonadotropin pregnancy test; d) Delivery of a neonate or other products of conception (abortus, stillborn); second, the death of the mother while pregnant or within 42 days of the termination of a pregnancy, irrespective of the duration and the site of the pregnancy; third, documentation of the maternal cause of death as one of the following: a) Direct: abortive outcome, hypertensive disorder, obstetric hemorrhage, pregnancy related infection, other obstetric complications, unanticipated complications; b) Indirect: non obstetric complications; c) Death during pregnancy, childbirth, and the puerperium: other or coincidental.	Level 1 Maternal Death		Level 1 Maternal Death is defined by three criteria: first, diagnosis of a pregnancy as established by any one of the following documented requirements: a) Ultrasound examination; b) Fetal heart tones; c) Positive serum or urine human chorionic gonadotropin pregnancy test; d) Delivery of a neonate or other products of conception (abortus, stillborn); second, the death of the mother while pregnant or within 42 days of the termination of a pregnancy, irrespective of the duration and the site of the pregnancy; third, documentation of the maternal cause of death as one of the following: a) Direct: abortive outcome, hypertensive disorder, obstetric hemorrhage, pregnancy related infection, other obstetric complications, unanticipated complications; b) Indirect: non obstetric complications; c) Death during pregnancy, childbirth, and the puerperium: other or coincidental.	C126858	GAIA Maternal Death Level of Diagnostic Certainty Terminology
C127981	GAIA Level 1 Maternal Immunization	GAIA Level 1 Maternal immunization is defined by three criteria: first, the pregnancy must be confirmed by either a positive pregnancy test or by ultrasound confirmation; second, the date/time of the immunization of the pregnant woman must be recorded in the medical records by the health care worker who administered/witnessed administration of vaccine; third, the details of vaccine must include the lot number and the date of immunization.	Level 1 Maternal Immunisation		Level 1 Maternal immunization is defined by three criteria: first, the pregnancy must be confirmed by either a positive pregnancy test or by ultrasound confirmation; second, the date/time of the immunization of the pregnant woman must be recorded in the medical records by the health care worker who administered/witnessed administration of vaccine; third, the details of vaccine must include the lot number and the date of immunization.	C126853	GAIA Neonatal Death Level of Diagnostic Certainty Terminology
C128744	GAIA Level 1 Morbidly Adherent Placentation	GAIA Level 1 Morbidly Adherent Placentation is defined by three criteria: first, evidence of placenta previa by either a second- or third-trimester ultrasound or an MRI; second, one of the following ultrasound features must be present: for Greyscale: a) Loss of the retroplacental sonolucent zone; OR b) Irregular retroplacental sonolucent zone; OR c) Thinning or disruption of the hyperechoic serosa-bladder interface; OR d) Presence of focal exophytic masses invading the urinary bladder; OR e) Abnormal placental lacunae; for Color Doppler: a) Diffuse or focal lacunar flow; OR b) Vascular lakes with turbulent flow (peak systolic velocity over 15 cm/s); OR c) Hypervascularity of serosa-bladder interface; OR d) Markedly dilated vessels over peripheral subplacental zone; for 3D Power Doppler: a) Numerous coherent vessels involving the entire uterine serosa-bladder junction (basal view); OR b) Hypervascularity (lateral view); OR c) Inseparable cotyledonal and intervillous circulations, chaotic branching, and detour vessels (lateral view); third, one of the following risk factors must be present: a) Prior cesarean delivery; OR b) Prior uterine surgery (including endometrial ablation); OR c) Cesarean scar pregnancy. Alternatively, Level 1 may be defined as morbidly adherent placentation found on histology in a hysterectomy or partial wedge resection specimen.	Level 1 Morbidly Adherent Placentation		Level 1 Morbidly Adherent Placentation is defined by three criteria: first, evidence of placenta previa by either a second- or third-trimester ultrasound or an MRI; second, one of the following ultrasound features must be present: for Greyscale: a) Loss of the retroplacental sonolucent zone; OR b) Irregular retroplacental sonolucent zone; OR c) Thinning or disruption of the hyperechoic serosa-bladder interface; OR d) Presence of focal exophytic masses invading the urinary bladder; OR e) Abnormal placental lacunae; for Color Doppler: a) Diffuse or focal lacunar flow; OR b) Vascular lakes with turbulent flow (peak systolic velocity over 15 cm/s); OR c) Hypervascularity of serosa-bladder interface; OR d) Markedly dilated vessels over peripheral subplacental zone; for 3D Power Doppler: a) Numerous coherent vessels involving the entire uterine serosa-bladder junction (basal view); OR b) Hypervascularity (lateral view); OR c) Inseparable cotyledonal and intervillous circulations, chaotic branching, and detour vessels (lateral view); third, one of the following risk factors must be present: a) Prior cesarean delivery; OR b) Prior uterine surgery (including endometrial ablation); OR c) Cesarean scar pregnancy. Alternatively, Level 1 may be defined as morbidly adherent placentation found on histology in a hysterectomy or partial wedge resection specimen.	C128706	GAIA Antenatal Bleeding Level of Diagnostic Certainty Terminology
C127969	GAIA Level 1 Neonatal Death in a Non-viable Live Birth	GAIA Level 1 Neonatal Death in a Non-viable Live Birth is defined by three criteria: first, the infant must be live born; second, at least one of the following requirements must be met: a) Gestational age less than 22 weeks (a GA level of certainty of one); OR b) Birth weight less than 500g; third, the death of the infant within the first 28 days of life must be documented.	Level 1 Neonatal Death in a Non-viable Live Birth		Level 1 Neonatal Death in a Non-viable Live Birth is defined by three criteria: first, the infant must be live born; second, at least one of the following requirements must be met: a) Gestational age less than 22 weeks (a GA level of certainty of one); OR b) Birth weight less than 500g; third, the death of the infant within the first 28 days of life must be documented.	C126853	GAIA Neonatal Death Level of Diagnostic Certainty Terminology
C127975	GAIA Level 1 Neonatal Death in a Preterm Live Birth	GAIA Level 1 Neonatal Death in a Preterm Live Birth is defined by three criteria: first, the infant must be live born; second, at least one of the following requirements must be met: a) Gestational age greater than or equal to 28 weeks and less than 37 weeks (where the GA level of certainty is one); OR b) Birth weight greater than or equal to 1000g but less than 2500g; third, the death of the infant within the first 28 days of life must be documented.	Level 1 Neonatal Death in a Preterm Live Birth		Level 1 Neonatal Death in a Preterm Live Birth is defined by three criteria: first, the infant must be live born; second, at least one of the following requirements must be met: a) Gestational age greater than or equal to 28 weeks and less than 37 weeks (where the GA level of certainty is one); OR b) Birth weight greater than or equal to 1000g but less than 2500g; third, the death of the infant within the first 28 days of life must be documented.	C126853	GAIA Neonatal Death Level of Diagnostic Certainty Terminology
C127978	GAIA Level 1 Neonatal Death in a Term Live Birth	GAIA Level 1 Neonatal Death in a Term Live Birth is defined by four criteria: first, the infant must be live born; second, the gestational age must be greater than or equal to 37 weeks (a GA level of certainty of one); third, at least one of the following requirements must be met: a) Birth weight greater than 2500g; OR b) Documented intra-uterine growth retardation if weight is less than or equal to 2500g; fourth, the death of the infant within the first 28 days of life must be documented.	Level 1 Neonatal Death in a Term Live Birth		Level 1 Neonatal Death in a Term Live Birth is defined by four criteria: first, the infant must be live born; second, the gestational age must be greater than or equal to 37 weeks (a GA level of certainty of one); third, at least one of the following requirements must be met: a) Birth weight greater than 2500g; OR b) Documented intra-uterine growth retardation if weight is less than or equal to 2500g; fourth, the death of the infant within the first 28 days of life must be documented.	C126853	GAIA Neonatal Death Level of Diagnostic Certainty Terminology
C127972	GAIA Level 1 Neonatal Death in an Extremely Preterm Live Birth	GAIA Level 1 Neonatal Death in an Extremely Preterm Live Birth is defined by three criteria: first, the infant must be live born; second, at least one of the following requirements must be met: a) Gestational age greater than or equal to 22 weeks and less than 28 weeks (where the GA level of certainty is one); OR b) Birth weight greater than or equal to 500g but less than 1000g. Third, the death of the infant within the first 28 days of life must be documented.	Level 1 Neonatal Death in an Extremely Preterm Live Birth		Level 1 Neonatal Death in an Extremely Preterm Live Birth is defined by three criteria: first, the infant must be live born; second, at least one of the following requirements must be met: a) Gestational age greater than or equal to 22 weeks and less than 28 weeks (where the GA level of certainty is one); OR b) Birth weight greater than or equal to 500g but less than 1000g. Third, the death of the infant within the first 28 days of life must be documented.	C126853	GAIA Neonatal Death Level of Diagnostic Certainty Terminology
C128729	GAIA Level 1 Neonatal Encephalopathy	GAIA Level 1 Neonatal Encephalopathy is defined by three criteria: first, a newborn infant (1-28 days of life) born at or beyond 35 weeks of gestation; second, an abnormal level of alertness or seizures; third, difficulty with initiating and maintaining respiration; fourth, depression of muscle tone.	Level 1 Neonatal Encephalopathy		Level 1 Neonatal Encephalopathy is defined by three criteria: first, a newborn infant (1-28 days of life) born at or beyond 35 weeks of gestation; second, an abnormal level of alertness or seizures; third, difficulty with initiating and maintaining respiration; fourth, depression of muscle tone.	C128699	GAIA Neonatal Encephalopathy Level of Diagnostic Certainty Terminology
C127987	GAIA Level 1 Neonatal Infectious Meningitis	GAIA Level 1 Neonatal Infectious Meningitis is defined by two criteria: first, the recognized pathogen must be identified, using a validated method, from cerebrospinal fluid (CSF); second, if an organism normally considered to be non-pathogenic is identified from the CSF, level 1 of diagnostic certainty additionally requires all level 2 criteria: i.e. CSF pleocytosis AND temperature criteria AND one or more clinical criteria.	Level 1 Neonatal Meningitis		Level 1 Neonatal Infectious Meningitis is defined by two criteria: first, the recognized pathogen must be identified, using a validated method, from cerebrospinal fluid (CSF); second, if an organism normally considered to be non-pathogenic is identified from the CSF, level 1 of diagnostic certainty additionally requires all level 2 criteria: i.e. CSF pleocytosis AND temperature criteria AND one or more clinical criteria.	C126854	GAIA Neonatal Infections Level of Diagnostic Certainty Terminology
C127984	GAIA Level 1 Neonatal Invasive Bloodstream Infection	GAIA Level 1 Neonatal Invasive Bloodstream Infection is defined by two criteria: first, identification of a recognized pathogen from a normally sterile site using a validated method; second, if a normally non-pathogenic organism is isolated from blood cultures the following two requirements must be met: a) The cultures must be obtained from two different sites OR taken at two different times; b) One or more of the level 2 criteria must be present.	Level 1 Neonatal Blood Stream Infection		Level 1 Neonatal Invasive Blood Stream Infection is defined by two criteria: first, identification of a recognized pathogen from a normally sterile site using a validated method; second, if a normally non-pathogenic organism is isolated from blood cultures the following two requirements must be met: a) The cultures must be obtained from two different sites OR taken at two different times; b) One or more of the level 2 criteria must be present.	C126854	GAIA Neonatal Infections Level of Diagnostic Certainty Terminology
C128768	GAIA Level 1 Neonatal Respiratory Distress	GAIA Level 1 Neonatal Respiratory Distress is defined by four criteria: first, the newborn must be between 0 and 28 days of life; second, the presence of any one of the following three symptoms that indicate an abnormal respiratory rate: a) Tachypnea (respiratory rate of 60 or more breaths per minute); b) Bradypnea (respiratory rate of less than 30 breaths per minute); c) Apnea [cessation of respiratory effort (no breaths) for at least 20 seconds]; third, one of the following five clinical symptoms that indicate labored breathing: a) Nasal flaring (dilatation of alae nasi); b) Noisy respirations in the form of expiratory grunting, stridor, or wheeze; c) Retractions or increased chest indrawings on inspiration (subcostal, intercostal, sternal, suprasternal notch); d) Central cyanosis (whole body, including lips and tongue) on room air; e) Low Apgar score (less than 7 points) at 10 minutes, with respiration score less than 2; fourth, examination and documentation by qualified, trained health care providers who are appropriate for the clinical setting.	Level 1 Neonatal Respiratory Distress		Level 1 Neonatal Respiratory Distress is defined by four criteria: first, the newborn must be between 0 and 28 days of life; second, the presence of any one of the following three symptoms that indicate an abnormal respiratory rate: a) Tachypnea (respiratory rate of 60 or more breaths per minute); b) Bradypnea (respiratory rate of less than 30 breaths per minute); c) Apnea [cessation of respiratory effort (no breaths) for at least 20 seconds]; third, one of the following five clinical symptoms that indicate labored breathing: a) Nasal flaring (dilatation of alae nasi); b) Noisy respirations in the form of expiratory grunting, stridor, or wheeze; c) Retractions or increased chest indrawings on inspiration (subcostal, intercostal, sternal, suprasternal notch); d) Central cyanosis (whole body, including lips and tongue) on room air; e) Low Apgar score (less than 7 points) at 10 minutes, with respiration score less than 2; fourth, examination and documentation by qualified, trained health care providers who are appropriate for the clinical setting.	C128702	GAIA Neonatal Respiratory Distress Level of Diagnostic Certainty Terminology
C127991	GAIA Level 1 Neonatal Respiratory Tract Infection	GAIA Level 1 Neonatal Respiratory Tract Infection is defined by two criteria: first, a new or progressive or persistent infiltrate or shadowing or fluid in the intrapleural cavity or interlobar fissure on chest X-ray OR a recognized virus identified using a validated assay from an upper respiratory sample OR a recognized pathogen identified, using a validated method, from a normally sterile site; second, three or more of the following requirements must be met: a) Temperature greater than or equal to 37.5 degrees C or less than 35.5 degrees C; b) Tachypnea or nasal flaring or chest indrawing or grunting; c) Desaturations or increased oxygen requirements or increased ventilator requirements or oxygen saturation less than 95%; d) Apnea; e) Increased respiratory secretions or increased suctioning requirements; f) Cough, wheeze, or crepitations; g) Increased CRP or procalcitonin.	Level 1 Neonatal Respiratory Tract Infection		Level 1 Neonatal Respiratory Tract Infection is defined by two criteria: first, a new or progressive or persistent infiltrate or shadowing or fluid in the intrapleural cavity or interlobar fissure on chest X-ray OR a recognized virus identified using a validated assay from an upper respiratory sample OR a recognized pathogen identified, using a validated method, from a normally sterile site; second, three or more of the following requirements must be met: a) Temperature greater than or equal to 37.5 degrees C or less than 35.5 degrees C; b) Tachypnea or nasal flaring or chest indrawing or grunting; c) Desaturations or increased oxygen requirements or increased ventilator requirements or oxygen saturation less than 95%; d) Apnea; e) Increased respiratory secretions or increased suctioning requirements; f) Cough, wheeze, or crepitations; g) Increased CRP or procalcitonin.	C126854	GAIA Neonatal Infections Level of Diagnostic Certainty Terminology
C127994	GAIA Level 1 Non-reassuring Fetal Status	GAIA Level 1 Non-reassuring Fetal Status is defined by two criteria: first, a Category III fetal heart rate tracing detected via continuous cardiotocography as defined by the NICHD; second, one of the following two conditions must be met: a) an absent baseline fetal heart rate variability AND any of the following: recurrent late decelerations, recurrent variable deceleration, bradycardia (less than 110 bpm); OR b) a sinusoidal pattern; third, umbilical cord blood analysis that is consistent with metabolic acidosis (pH less than 7.0 and a base deficit greater than 12mmol/L).	Level 1 Non-reassuring Fetal Status		Level 1 Non-reassuring Fetal Status is defined by two criteria: first, a Category III fetal heart rate tracing detected via continuous cardiotocography as defined by the NICHD; second, one of the following two conditions must be met: a) an absent baseline fetal heart rate variability AND any of the following: recurrent late decelerations, recurrent variable deceleration, bradycardia (less than 110 bpm); OR b) a sinusoidal pattern; third, umbilical cord blood analysis that is consistent with metabolic acidosis (pH less than 7.0 and a base deficit greater than 12mmol/L).	C126857	GAIA Non-Reassuring Fetal Status Level of Diagnostic Certainty Terminology
C128742	GAIA Level 1 Placenta Previa	GAIA Level 1 Placenta Previa is defined by a second or third trimester ultrasound (and/or MRI) that demonstrates evidence of placental tissue overlying or abutting the internal cervical os.	Level 1 Placenta Previa		Level 1 Placenta Previa is defined by a second or third trimester ultrasound (and/or MRI) that demonstrates evidence of placental tissue overlying or abutting the internal cervical os.	C128706	GAIA Antenatal Bleeding Level of Diagnostic Certainty Terminology
C128748	GAIA Level 1 Placental Abruption	GAIA Level 1 Placental Abruption is defined by two criteria: first, vaginal bleeding during the second or third trimester in the absence of placenta previa on ultrasound; second, one of the following two requirements must be met: a) Uterine irritability (irregular, frequent uterine activity, not coalesced into clear contractions in a regular pattern) or labor; OR b) Clinical signs of hypovolemic shock or coagulopathy. Alternatively, Level 1 may be defined as placental pathology with histologic findings of a chronic abruption.	Level 1 Placental Abruption		Level 1 Placental Abruption is defined by two criteria: first, vaginal bleeding during the second or third trimester in the absence of placenta previa on ultrasound; second, one of the following two requirements must be met: a) Uterine irritability (irregular, frequent uterine activity, not coalesced into clear contractions in a regular pattern) or labor; OR b) Clinical signs of hypovolemic shock or coagulopathy. Alternatively, Level 1 may be defined as placental pathology with histologic findings of a chronic abruption.	C128706	GAIA Antenatal Bleeding Level of Diagnostic Certainty Terminology
C128757	GAIA Level 1 Postnatally Diagnosed Congenital Microcephaly	GAIA Level 1 Postnatally Diagnosed Congenital Microcephaly is defined by three criteria: first, a live birth, stillbirth, or spontaneous or therapeutic abortion of at least 24 weeks Gestational Age (GA), with GA assessed by either a certain last menstrual period (LMP) date with confirmatory 1st trimester (less than 14 weeks) or 2nd trimester ultrasound (US) scan OR intrauterine insemination (IUI) OR embryo transfer date; second, a head circumference (HC) measurement either 2 standard deviations (SD) below the mean or less than the third percentile as assessed by GA and gender, using appropriate, standardized reference charts for the population (e.g. WHO growth reference charts if GA greater than or equal to 37 weeks and Intergrowth-21st reference charts for GA 24 to 36 weeks); third, the measurement is taken either between 24 and 36 hours after birth or at the end of the pregnancy.	Level 1 Postnatally Diagnosed Congenital Microcephaly		Level 1 Postnatally Diagnosed Congenital Microcephaly is defined by three criteria: first, a live birth, stillbirth, or spontaneous or therapeutic abortion of at least 24 weeks Gestational Age (GA), with GA assessed by either a certain last menstrual period (LMP) date with confirmatory 1st trimester (less than 14 weeks) or 2nd trimester ultrasound (US) scan OR intrauterine insemination (IUI) OR embryo transfer date; second, a head circumference (HC) measurement either 2 standard deviations (SD) below the mean or less than the third percentile as assessed by GA and gender, using appropriate, standardized reference charts for the population (e.g. WHO growth reference charts if GA greater than or equal to 37 weeks and Intergrowth-21st reference charts for GA 24 to 36 weeks); third, the measurement is taken either between 24 and 36 hours after birth or at the end of the pregnancy.	C128700	GAIA Congenital Microcephaly Level of Diagnostic Certainty Terminology
C128000	GAIA Level 1 Postpartum Hemorrhage	GAIA Level 1 Postpartum Hemorrhage is the presence of genital bleeding after delivery, leading to severe maternal outcome (maternal death or maternal near miss) as defined by WHO.	Level 1 Postpartum Haemorrhage		Level 1 Postpartum Hemorrhage is the presence of genital bleeding after delivery, leading to severe maternal outcome (maternal death or maternal near miss) as defined by WHO.	C126859	GAIA Postpartum Hemorrhage Level of Diagnostic Certainty Terminology
C128003	GAIA Level 1 Preeclampsia	GAIA Level 1 Preeclampsia is defined by three criteria: first, the gestational age of the pregnancy must be greater than or equal to 20 weeks; second, a diagnosis of new onset maternal hypertension (systolic blood pressure greater than or equal to 140mmHg and/or diastolic blood pressure greater than or equal to 90mmHg) that is sustained on two measurements over a minimum of one hour; third, a diagnosis of new onset proteinuria that is a level one diagnostic certainty (proteinuria diagnosed with greater than or equal to 300 mg of protein during 24 hour urine collection OR greater than or equal to 0.3 for spot protein:creatinine ratio.)	Level 1 Preeclampsia		Level 1 Preeclampsia is defined by three criteria: first, the gestational age of the pregnancy must be greater than or equal to 20 weeks; second, a diagnosis of new onset maternal hypertension (systolic blood pressure greater than or equal to 140mmHg and/or diastolic blood pressure greater than or equal to 90mmHg) that is sustained on two measurements over a minimum of one hour; third, a diagnosis of new onset proteinuria that is a level one diagnostic certainty (proteinuria diagnosed with greater than or equal to 300 mg of protein during 24 hour urine collection OR greater than or equal to 0.3 for spot protein:creatinine ratio.)	C126860	GAIA Preeclampsia Level of Diagnostic Certainty Terminology
C128006	GAIA Level 1 Preeclampsia with Severe Features	GAIA Level 1 Preeclampsia with Severe Features is defined by three criteria: first, the gestational age of the pregnancy must be greater than or equal to 20 weeks; second, a diagnosis of new onset maternal hypertension (systolic blood pressure greater than or equal to 140mmHg and/or diastolic blood pressure greater than or equal to 90mmHg) that is sustained on two measurements over a minimum of one hour); third, the presence of one or more of the following requirements: a) Systolic blood pressure greater than or equal to 160mmHg and/or diastolic blood pressure greater than or equal to 110mmHg, which is confirmed after only minutes; b) Development of severe, persistent headache; c) Development of visual changes; d) Eclampsia; e) New onset thrombocytopenia (platelets less than 100,000/microliter); f) New onset unremitting epigastric pain; g) AST and ALT elevated to twice the upper limit of normal; h) Evidence of liver capsular hematoma or liver rupture (diagnosed on clinical exam or with imaging); i) Worsening renal function, as evidenced by serum creatinine level greater than 1.1 mg/dL, a doubling of the serum creatinine (absent other renal disease), or oliguria (less than 500 cc/24 hours); j) Pulmonary edema (confirmed on either imaging with chest x-ray or on clinical exam).	Level 1 Preeclampsia with Severe Features		Level 1 Preeclampsia with Severe Features is defined by three criteria: first, the gestational age of the pregnancy must be greater than or equal to 20 weeks; second, a diagnosis of new onset maternal hypertension (systolic blood pressure greater than or equal to 140mmHg and/or diastolic blood pressure greater than or equal to 90mmHg) that is sustained on two measurements over a minimum of one hour); third, the presence of one or more of the following requirements: a) Systolic blood pressure greater than or equal to 160mmHg and/or diastolic blood pressure greater than or equal to 110mmHg, which is confirmed after only minutes; b) Development of severe, persistent headache; c) Development of visual changes; d) Eclampsia; e) New onset thrombocytopenia (platelets less than 100,000/microliter); f) New onset unremitting epigastric pain; g) AST and ALT elevated to twice the upper limit of normal; h) Evidence of liver capsular hematoma or liver rupture (diagnosed on clinical exam or with imaging); i) Worsening renal function, as evidenced by serum creatinine level greater than 1.1 mg/dL, a doubling of the serum creatinine (absent other renal disease), or oliguria (less than 500 cc/24 hours); j) Pulmonary edema (confirmed on either imaging with chest x-ray or on clinical exam).	C126860	GAIA Preeclampsia Level of Diagnostic Certainty Terminology
C128781	GAIA Level 1 Second Trimester Spontaneous Abortion	GAIA Level 1 Second Trimester Spontaneous Abortion is defined by two criteria: first, gestational age is within the pre-defined range for the selected abortion definition as assessed by maternal and/or fetal parameters (Level 1-2) (Brighton Preterm Birth Gestational Age algorithm); second, at least one of the following requirements must be met: a) No visible heartbeat on ultrasound; OR b) Visible expulsion of pregnancy tissues/products of conception on examination of the cervix; OR c) Products of conception found on histopathological evaluation of uterine contents.	Level 1 Second Trimester Spontaneous Abortion		Level 1 Second Trimester Spontaneous Abortion is defined by two criteria: first, gestational age is within the pre-defined range for the selected abortion definition as assessed by maternal and/or fetal parameters (Level 1-2) (Brighton Preterm Birth Gestational Age algorithm); second, at least one of the following requirements must be met: a) No visible heartbeat on ultrasound; OR b) Visible expulsion of pregnancy tissues/products of conception on examination of the cervix; OR c) Products of conception found on histopathological evaluation of uterine contents.	C128705	GAIA Spontaneous Abortion and Ectopic Pregnancy Level of Diagnostic Certainty Terminology
C128733	GAIA Level 1 Small for Gestational Age	GAIA Level 1 Small for Gestational Age is defined by three criteria: first, weight below the 10th percentile for gestational age; second, assessment of weight by both of the following: a) Newborn weighed within 24 hours of birth; AND b) Weight assessed using a calibrated electronic scale with 10 g resolution; third, the gestational age is assessed by confirmatory ultrasound during the first trimester, with or without certain LMP, or IUI or embryo transfer date OR by first trimester ultrasound.	Level 1 Small for Gestational Age		Level 1 Small for Gestational Age is defined by three criteria: first, weight below the 10th percentile for gestational age; second, assessment of weight by both of the following: a) Newborn weighed within 24 hours of birth; AND b) Weight assessed using a calibrated electronic scale with 10 g resolution; third, the gestational age is assessed by confirmatory ultrasound during the first trimester, with or without certain LMP, or IUI or embryo transfer date OR by first trimester ultrasound.	C128703	GAIA Small for Gestational Age Level of Diagnostic Certainty Terminology
C128752	GAIA Level 1 Uterine Rupture	GAIA Level 1 Uterine Rupture is the complete disruption of the uterus, at the time of laparotomy, in the context of vaginal or intra-abdominal bleeding.	Level 1 Uterine Rupture		Level 1 Uterine Rupture is the complete disruption of the uterus, at the time of laparotomy, in the context of vaginal or intra-abdominal bleeding.	C128706	GAIA Antenatal Bleeding Level of Diagnostic Certainty Terminology
C128746	GAIA Level 1 Vasa Previa	GAIA Level 1 Vasa Previa is defined by two criteria: first, second trimester ultrasound evidence of fetal vessels (vessel with fetal heart rate identified by color flow Doppler) traversing the membranes and overlying the internal cervical os; second, post-delivery examination of the placental specimen that demonstrates unsupported fetal vessels within the membranes.	Level 1 Vasa Previa		Level 1 Vasa Previa is defined by two criteria: first, second trimester ultrasound evidence of fetal vessels (vessel with fetal heart rate identified by color flow Doppler) traversing the membranes and overlying the internal cervical os; second, post-delivery examination of the placental specimen that demonstrates unsupported fetal vessels within the membranes.	C128706	GAIA Antenatal Bleeding Level of Diagnostic Certainty Terminology
C128721	GAIA Level 1a Fetal Growth Restriction	GAIA Level 1a Fetal Growth Restriction is defined by two criteria: first, Level 1 evidence of pregnancy dating; second, at least one of the following requirements must be met: a) Estimated fetal weight below the third percentile using locally-accepted growth curve; OR b) Estimated fetal weight below the tenth percentile using locally-accepted growth curve AND either findings of absent or reversed end-diastolic flow of the umbilical artery Doppler OR a finding of oligohydramnios.	Level 1a Fetal Growth Restriction		Level 1a Fetal Growth Restriction is defined by two criteria: first, Level 1 evidence of pregnancy dating; second, at least one of the following requirements must be met: a) Estimated fetal weight below the third percentile using locally-accepted growth curve; OR b) Estimated fetal weight below the tenth percentile using locally-accepted growth curve AND either findings of absent or reversed end-diastolic flow of the umbilical artery Doppler OR a finding of oligohydramnios.	C128708	GAIA Fetal Growth Restriction Level of Diagnostic Certainty Terminology
C128762	GAIA Level 1a Prenatally Diagnosed Congenital Microcephaly	GAIA Level 1a Prenatally Diagnosed Congenital Microcephaly is defined by three criteria: first, the fetus is at least 24 weeks gestational age (GA) based on certain last menstrual period (LMP) date with confirmatory 1st trimester or 2nd trimester ultrasound (US) scan OR intrauterine insemination (IUI) or embryo transfer date; second, a head circumference (HC) measurement either 2 standard deviations (SD) below the mean or less than the third percentile according to fetal US examination, using appropriate, standardized reference charts according to GA and gender for the population (e.g. WHO growth reference charts if GA greater than or equal to 37 weeks and Intergrowth-21st reference charts for GA 24-36 weeks); third, confirmation of microcephaly (i.e., HC 2 SD below the mean or less than 3%) in the fetus by either at least one additional US after 24 weeks that occurs at least one week after the first US, OR confirmation of microcephaly by HC measurement with a standard tape measure at either birth or autopsy.	Level 1a Prenatally Diagnosed Congenital Microcephaly		Level 1a Prenatally Diagnosed Congenital Microcephaly is defined by three criteria: first, the fetus is at least 24 weeks gestational age (GA) based on certain last menstrual period (LMP) date with confirmatory 1st trimester or 2nd trimester ultrasound (US) scan OR intrauterine insemination (IUI) or embryo transfer date; second, a head circumference (HC) measurement either 2 standard deviations (SD) below the mean or less than the third percentile according to fetal US examination, using appropriate, standardized reference charts according to GA and gender for the population (e.g. WHO growth reference charts if GA greater than or equal to 37 weeks and Intergrowth-21st reference charts for GA 24-36 weeks); third, confirmation of microcephaly (i.e., HC 2 SD below the mean or less than 3%) in the fetus by either at least one additional US after 24 weeks that occurs at least one week after the first US, OR confirmation of microcephaly by HC measurement with a standard tape measure at either birth or autopsy.	C128700	GAIA Congenital Microcephaly Level of Diagnostic Certainty Terminology
C128722	GAIA Level 1b Fetal Growth Restriction	GAIA Level 1b Fetal Growth Restriction is defined by two criteria: first, Level 1 evidence of pregnancy dating; second, an estimated fetal weight below the tenth percentile using locally-accepted growth curve AND either no findings of absent or reversed end-diastolic flow of the umbilical artery Doppler OR absence of oligohydramnios.	Level 1b Fetal Growth Restriction		Level 1b Fetal Growth Restriction is defined by two criteria: first, Level 1 evidence of pregnancy dating; second, an estimated fetal weight below the tenth percentile using locally-accepted growth curve AND either no findings of absent or reversed end-diastolic flow of the umbilical artery Doppler OR absence of oligohydramnios.	C128708	GAIA Fetal Growth Restriction Level of Diagnostic Certainty Terminology
C128763	GAIA Level 1b Prenatally Diagnosed Congenital Microcephaly	GAIA Level 1b Prenatally Diagnosed Congenital Microcephaly is defined by three criteria: first, the fetus is at least 24 weeks gestational age (GA) based on uncertain last menstrual period (LMP) date with a 2nd trimester ultrasound (US) scan; second, a head circumference (HC) measurement either 2 standard deviations (SD) below the mean or less than the third percentile according to fetal US examination, using appropriate, standardized reference charts according to GA and gender for the population (e.g. WHO growth reference charts if GA greater than or equal to 37 weeks and Intergrowth-21st reference charts for GA 24-36 weeks); third, confirmation of microcephaly (i.e., HC 2 SD below the mean or less than 3%) in the fetus by either at least one additional US after 24 weeks that occurs at least one week after the first US, OR confirmation of microcephaly by HC measurement with a standard tape measure at either birth or autopsy.	Level 1b Prenatally Diagnosed Congenital Microcephaly		Level 1b Prenatally Diagnosed Congenital Microcephaly is defined by three criteria: first, the fetus is at least 24 weeks gestational age (GA) based on uncertain last menstrual period (LMP) date with a 2nd trimester ultrasound (US) scan; second, a head circumference (HC) measurement either 2 standard deviations (SD) below the mean or less than the third percentile according to fetal US examination, using appropriate, standardized reference charts according to GA and gender for the population (e.g. WHO growth reference charts if GA greater than or equal to 37 weeks and Intergrowth-21st reference charts for GA 24-36 weeks); third, confirmation of microcephaly (i.e., HC 2 SD below the mean or less than 3%) in the fetus by either at least one additional US after 24 weeks that occurs at least one week after the first US, OR confirmation of microcephaly by HC measurement with a standard tape measure at either birth or autopsy.	C128700	GAIA Congenital Microcephaly Level of Diagnostic Certainty Terminology
C128019	GAIA Level 2 Antepartum Stillbirth	GAIA Level 2 Antepartum Stillbirth is defined by four criteria: first, delivery of an infant with no of signs of life at birth, including the following: no spontaneous movements, no umbilical cord pulse, no heartbeat, no respirations, and an Apgar score of 0 at both 1 and 5 minutes. Determination of the absence of signs of life is made by physical examination after delivery, with or without electronic monitoring of heart rate, respiratory rate, and pulse oximetry; second, one or more of the following three requirements must be met: a) Maternal report of the absence of fetal movement for 24 hours or more; b) Maternal physical examination confirming the absence of fetal movement; c) Auscultation for fetal heart tones using electronic devices (e.g. handheld Doppler or fetal heart rate monitor) or non-electronic devices (e.g. stethoscope, fetoscope or Pinard horn) that documents the absence of a fetal heartbeat; third, one or more of the following two requirements must be met: a) Attended delivery followed by a post-delivery physical examination of the fetus that is performed by specialist or qualified trained practitioner appropriate to the health care setting, and that is consistent with antepartum death; b) fetal/placental pathology report that is consistent with antepartum death; fourth, gestational age within the pre-defined range for selected stillbirth definition, as assessed by maternal and/or fetal parameters (level 1-2 in GA assessment algorithm).	Level 2 Antepartum Stillbirth		Level 2 Antepartum Stillbirth is defined by four criteria: first, delivery of an infant with no of signs of life at birth, including the following: no spontaneous movements, no umbilical cord pulse, no heartbeat, no respirations, and an Apgar score of 0 at both 1 and 5 minutes. Determination of the absence of signs of life is made by physical examination after delivery, with or without electronic monitoring of heart rate, respiratory rate, and pulse oximetry; second, one or more of the following three requirements must be met: a) Maternal report of the absence of fetal movement for 24 hours or more; b) Maternal physical examination confirming the absence of fetal movement; c) Auscultation for fetal heart tones using electronic devices (e.g. handheld Doppler or fetal heart rate monitor) or non-electronic devices (e.g. stethoscope, fetoscope or Pinard horn) that documents the absence of a fetal heartbeat; third, one or more of the following two requirements must be met: a) Attended delivery followed by a post-delivery physical examination of the fetus that is performed by specialist or qualified trained practitioner appropriate to the health care setting, and that is consistent with antepartum death; b) fetal/placental pathology report that is consistent with antepartum death; fourth, gestational age within the pre-defined range for selected stillbirth definition, as assessed by maternal and/or fetal parameters (level 1-2 in GA assessment algorithm).	C126856	GAIA Stillbirth Level of Diagnostic Certainty Terminology
C127954	GAIA Level 2 Assessment of Insufficient Cervix	GAIA Level 2 Assessment of Insufficient Cervix is defined by two criteria: first, the following three requirements must be met: a) Presentation between 16 and 23 6/7 weeks gestation; b) Advanced cervical dilation greater than two centimeters, resulting in either treatment with a cerclage (cervical stitch) or preterm delivery; c) less than or equal to four contractions per hour as documented by a tocodynometer, meaning the patient is not in preterm labor; second, dilation of the internal cervical os greater than two centimeters as determined by digital examination.	Level 2 Assessment of Insufficient Cervix		Level 2 Assessment of Insufficient Cervix is defined by two criteria: first, the following three requirements must be met: a) Presentation between 16 and 23 6/7 weeks gestation; b) Advanced cervical dilation greater than two centimeters, resulting in either treatment with a cerclage (cervical stitch) or preterm delivery; c) less than or equal to four contractions per hour as documented by a tocodynometer, meaning the patient is not in preterm labor; second, dilation of the internal cervical os greater than two centimeters as determined by digital examination.	C126861	GAIA Pathways to Preterm Birth Level of Diagnostic Certainty Terminology
C127945	GAIA Level 2 Assessment of Premature Preterm Rupture of Membranes	GAIA Level 2 Assessment of Premature Preterm Rupture of Membranes is defined by four criteria: first, presentation between 24 0/7 and 36 6/7 weeks gestation with a clinical history of rupture of membranes, the fluid from which may be any color, including clear, blood-tinged, meconium-tinged (fetal stool), or purulent-tinged (yellowish, suggesting infection); second, the patient is determined to not be in preterm labor (having less than or equal to 4 contractions per hour documented clinically or on tocodynometer, with less than 2cm cervical dilation); third, visible leakage of fluid on vaginal speculum exam; fourth, one of the three following requirements must be met: a) Visible arborization (ferning) on microscopy of amniotic fluid; OR b) Ultrasound with oligohydramnios (amniotic fluid index (AFI) less than 5, or maximum vertical pocket (MVP) less than; OR c) documentation of the membrane rupture by one of the following diagnostic tests: 1) Positive intra-amniotic dye-injection method; 2) Positive result on amniotic fluid alpha-fetoprotein test kit; 3) Amniotic fluid pH measurement (nitrazine paper test); 4) Amniotic fluid placental alpha macroglobulin-1 protein assay (PAMG-1) test (AmniSure test); 5) Amniotic fluid insulin-like growth factor binding protein (IGFBP-1) test (Actim PROM test).	Level 2 Assessment of Premature Preterm Rupture of Membranes		Level 2 Assessment of Premature Preterm Rupture of Membranes is defined by four criteria: first, presentation between 24 0/7 and 36 6/7 weeks gestation with a clinical history of rupture of membranes, the fluid from which may be any colour, including clear, blood-tinged, meconium-tinged (fetal stool), or purulent-tinged (yellowish, suggesting infection); second, the patient is determined to not be in preterm labor (having less than or equal to 4 contractions per hour documented clinically or on tocodynometer, with less than 2cm cervical dilation); third, visible leakage of fluid on vaginal speculum exam; fourth, one of the three following requirements must be met: a) Visible arborization (ferning) on microscopy of amniotic fluid; OR b) Ultrasound with oligohydramnios (amniotic fluid index (AFI) less than 5, or maximum vertical pocket (MVP) less than; OR c) documentation of the membrane rupture by one of the following diagnostic tests: 1) Positive intra-amniotic dye-injection method; 2) Positive result on amniotic fluid alpha-fetoprotein test kit; 3) Amniotic fluid pH measurement (nitrazine paper test); 4) Amniotic fluid placental alpha macroglobulin-1 protein assay (PAMG-1) test (AmniSure test); 5) Amniotic fluid insulin-like growth factor binding protein (IGFBP-1) test (Actim PROM test).	C126861	GAIA Pathways to Preterm Birth Level of Diagnostic Certainty Terminology
C127948	GAIA Level 2 Assessment of Preterm Labor	GAIA Level 2 Assessment of Preterm Labor is defined by three criteria: first, confirmed delivery of a fetus between 24 0/7 and 36 6/7 weeks gestation; second, greater than four uterine contractions per hour as determined by a tocodynometer OR by clinical assessment; third, documented change in length or dilation of the cervix by physical examination, with clinical criteria obtained by digital examination, including: a) Cervical dilation of two centimeters or more at the internal os; b) Cervical length of one centimeter or less; c) greater than or equal to 50% effacement of the cervix.	Level 2 Assessment of Preterm Labor		Level 2 Assessment of Preterm Labor is defined by three criteria: first, confirmed delivery of a fetus between 24 0/7 and 36 6/7 weeks gestation; second, greater than four uterine contractions per hour as determined by a tocodynometer OR by clinical assessment; third, documented change in length or dilation of the cervix by physical examination, with clinical criteria obtained by digital examination, including: a) Cervical dilation of two centimeters or more at the internal os; b) Cervical length of one centimeter or less; c) greater than or equal to 50% effacement of the cervix.	C126861	GAIA Pathways to Preterm Birth Level of Diagnostic Certainty Terminology
C127951	GAIA Level 2 Assessment of Provider Initiated Preterm Delivery	GAIA Level 2 Assessment of Provider-Initiated Preterm Delivery is defined by three criteria: first, the patient is determined to be between 24 0/7 and 36 6/7 weeks gestation; second, a report from the delivering provider, based on recall, that there were no signs or symptoms of the spontaneous onset of preterm labor; third, additional documentation of the need to induce labor or to perform a cesarean delivery, resulting in a preterm delivery.	Level 2 Assessment of Provider-Initiated Preterm Delivery		Level 2 Assessment of Provider-Initiated Preterm Delivery is defined by three criteria: first, the patient is determined to be between 24 0/7 and 36 6/7 weeks gestation; second, a report from the delivering provider, based on recall, that there were no signs or symptoms of the spontaneous onset of preterm labor; third, additional documentation of the need to induce labor or to perform a cesarean delivery, resulting in a preterm delivery.	C126861	GAIA Pathways to Preterm Birth Level of Diagnostic Certainty Terminology
C128718	GAIA Level 2 Dysfunctional First Stage of Labor	GAIA Level 2 Dysfunctional First Stage of Labor is defined by progress of less than 0.5 cm of cervical dilation per hour, for at least 4 hours, in women with established labor (i.e. have regular contractions and cervical dilation of at least 4 cm) without certainty of ruptured membranes.	Level 2 Dysfunctional First Stage of Labor		Level 2 Dysfunctional First Stage of Labor is defined by progress of less than 0.5 cm of cervical dilation per hour, for at least 4 hours, in women with established labor (i.e. have regular contractions and cervical dilation of at least 4 cm) without certainty of ruptured membranes.	C128707	GAIA Dysfunctional Labor Level of Diagnostic Certainty Terminology
C128720	GAIA Level 2 Dysfunctional Second Stage of Labor	GAIA Level 2 Dysfunctional Second Stage of Labor is defined by two criteria. For nulliparous and multiparous women: first, full dilation of the cervix (10 cm dilated, or no palpable cervix around the presenting part of the fetus) during any phase of the second stage of labor; second, at least one of the following requirements must be met: a) No delivery within 3 hours of full dilation; OR b) The use of an instrument (forceps or vacuum/ventouse) for the indication of dystocia; OR d) Cesarean delivery for the indication of dystocia.	Level 2 Dysfunctional Second Stage of Labor		Level 2 Dysfunctional Second Stage of Labor is defined by two criteria. For nulliparous and multiparous women: first, full dilation of the cervix (10 cm dilated, or no palpable cervix around the presenting part of the fetus) during any phase of the second stage of labor; second, at least one of the following requirements must be met: a) No delivery within 3 hours of full dilation; OR b) The use of an instrument (forceps or vacuum/ventouse) for the indication of dystocia; OR d) Cesarean delivery for the indication of dystocia.	C128707	GAIA Dysfunctional Labor Level of Diagnostic Certainty Terminology
C128711	GAIA Level 2 Ectopic Pregnancy	GAIA Level 2 Ectopic Pregnancy is defined by three criteria: first, it does not qualify as a Level 1 Ectopic Pregnancy; second, gestational age is within the pre-defined range for the selected ectopic pregnancy definition as assessed by maternal and/or fetal parameters (Level 1-2) (Brighton Preterm Birth Gestational Age algorithm); third, at least one of the following two requirements must be met: a) Transvaginal ultrasound showing no intrauterine pregnancy; OR b) No products of conception found on endometrial curettage after dilation and curettage procedure.	Level 2 Ectopic Pregnancy		Level 2 Ectopic Pregnancy is defined by three criteria: first, it does not qualify as a Level 1 Ectopic Pregnancy; second, gestational age is within the pre-defined range for the selected ectopic pregnancy definition as assessed by maternal and/or fetal parameters (Level 1-2) (Brighton Preterm Birth Gestational Age algorithm); third, at least one of the following two requirements must be met: a) Transvaginal ultrasound showing no intrauterine pregnancy; OR b) No products of conception found on endometrial curettage after dilation and currettage procedure.	C128705	GAIA Spontaneous Abortion and Ectopic Pregnancy Level of Diagnostic Certainty Terminology
C128777	GAIA Level 2 First Trimester Spontaneous Abortion	GAIA Level 2 First Trimester Spontaneous Abortion is defined by three criteria: first, it does not qualify as a Level 1 First Trimester Spontaneous Abortion; second, at least one of the following three requirements must be met: a) Crown-rump length greater than 7 mm and no visible heartbeat, confirmed by transvaginal ultrasound; OR b) Crown-rump length greater than 15 mm and no visible heartbeat, confirmed by abdominal ultrasound; OR c) Mean gestational sac diameter is 25 mm or more and no visible embryo; third, gestational age is within the pre-defined range for the selected abortion definition as assessed by maternal and/or fetal parameters (Level 1-2) (using Brighton Preterm Birth Gestational Age algorithm).	Level 2 First Trimester Spontaneous Abortion		Level 2 First Trimester Spontaneous Abortion is defined by three criteria: first, it does not qualify as a Level 1 First Trimester Spontaneous Abortion; second, at least one of the following three requirements must be met: a) Crown-rump length greater than 7 mm and no visible heartbeat, confirmed by transvaginal ultrasound; OR b) Crown-rump length greater than 15 mm and no visible heartbeat, confirmed by abdominal ultrasound; OR c) Mean gestational sac diameter is 25 mm or more and no visible embryo; third, gestational age is within the pre-defined range for the selected abortion definition as assessed by maternal and/or fetal parameters (Level 1-2) (using Brighton Preterm Birth Gestational Age algorithm).	C128705	GAIA Spontaneous Abortion and Ectopic Pregnancy Level of Diagnostic Certainty Terminology
C128754	GAIA Level 2 Gestational Diabetes Mellitus	GAIA Level 2 Gestational Diabetes Mellitus is defined by three criteria: first, absence of pre-gestational diabetes [pre-gestational diabetes is defined as a) previous diagnosis of diabetes while not pregnant OR b) first trimester hemoglobin A1c level of greater than or equal to 6.5% (47.5 mmol/mol) OR c) first trimester fasting blood glucose greater than or equal to 126 mg/dL (7 mmol/L)]; second, gestational age with at least level 1-2 certainty, using the GAIA definition for gestational age; third the diagnosis of gestational diabetes as determined by a positive result from an international standard oral glucose tolerance test using capillary blood samples.	Level 2 Gestational Diabetes Mellitus		Level 2 Gestational Diabetes Mellitus is defined by three criteria: first, absence of pre-gestational diabetes [pre-gestational diabetes is defined as a) previous diagnosis of diabetes while not pregnant OR b) first trimester hemoglobin A1c level of greater than or equal to 6.5% (47.5 mmol/mol) OR c) first trimester fasting blood glucose greater than or equal to 126 mg/dL (7 mmol/L)]; second, gestational age with at least level 1-2 certainty, using the GAIA definition for gestational age; third the diagnosis of gestational diabetes as determined by a positive result from an international standard oral glucose tolerance test using capillary blood samples.	C128709	GAIA Gestational Diabetes Mellitus Level of Diagnostic Certainty Terminology
C128010	GAIA Level 2 Gestational Hypertension	GAIA Level 2 Gestational Hypertension is defined by four criteria: first, the gestational age of the pregnancy must be greater than or equal to 20 weeks; second, a diagnosis of new onset maternal hypertension (systolic blood pressure greater than or equal to 140mmHg and/or diastolic blood pressure greater than or equal to 90mmHg) that is sustained on two measurements for a minimum of one hour; third, the absence of any severe features (see preeclampsia with severe features category); fourth, the absence of proteinuria (as defined by urine dipstick result of negative or trace).	Level 2 Gestational Hypertension		Level 2 Gestational Hypertension is defined by four criteria: first, the gestational age of the pregnancy must be greater than or equal to 20 weeks; second, a diagnosis of new onset maternal hypertension (systolic blood pressure greater than or equal to 140mmHg and/or diastolic blood pressure greater than or equal to 90mmHg) that is sustained on two measurements for a minimum of one hour; third, the absence of any severe features (see preeclampsia with severe features category); fourth, the absence of proteinuria (as defined by urine dipstick result of negative or trace).	C126860	GAIA Preeclampsia Level of Diagnostic Certainty Terminology
C128023	GAIA Level 2 Intrapartum Stillbirth	GAIA Level 2 Intrapartum Stillbirth is defined by four criteria: first, the delivery of an infant with no signs of life at birth, including the following: no spontaneous movements, no umbilical cord pulse, no heartbeat, no respirations, and an Apgar score of 0 at both 1 and 5 minutes. Determination of the absence of signs of life is made by physical examination after delivery, with or without electronic monitoring of heart rate, respiratory rate, and pulse oximetry OR documentation of lack of response to resuscitation efforts; second, evidence of a live fetus prior to the onset of labor (maternal report of fetal movement prior to the onset of labor and documentation of fetal heart tones by auscultation or hand held Doppler). NOTE: In the absence of evidence of a live fetus prior to the onset of labor, the fetal death should be reported as a stillbirth or an antepartum stillbirth; third, attended delivery followed by post-delivery physical examination that is performed by a health care professional who meets the standard of care in the immediate health care setting, and which is consistent with intrapartum death; fourth, gestational age within the pre-defined range for selected stillbirth definition as assessed by maternal and/or fetal parameters (level 1-2 in GA assessment algorithm).	Level 2 Intrapartum Stillbirth		Level 2 Intrapartum Stillbirth is defined by four criteria: first, the delivery of an infant with no signs of life at birth, including the following: no spontaneous movements, no umbilical cord pulse, no heartbeat, no respirations, and an Apgar score of 0 at both 1 and 5 minutes. Determination of the absence of signs of life is made by physical examination after delivery, with or without electronic monitoring of heart rate, respiratory rate, and pulse oximetry OR documentation of lack of response to resuscitation efforts; second, evidence of a live fetus prior to the onset of labor (maternal report of fetal movement prior to the onset of labor and documentation of fetal heart tones by auscultation or hand held Doppler). NOTE: In the absence of evidence of a live fetus prior to the onset of labor, the fetal death should be reported as a stillbirth or an antepartum stillbirth; third, attended delivery followed by post-delivery physical examination that is performed by a health care professional who meets the standard of care in the immediate health care setting, and which is consistent with intrapartum death; fourth, gestational age within the pre-defined range for selected stillbirth definition as assessed by maternal and/or fetal parameters (level 1-2 in GA assessment algorithm).	C126856	GAIA Stillbirth Level of Diagnostic Certainty Terminology
C128726	GAIA Level 2 Low Birth Weight	GAIA Level 2 Low Birth Weight is defined by either one of the following two criteria: first, a newborn infant is weighed within 24 hours of birth; either an electronic or a spring scale that is graduated to 50 grams is used; the scale is calibrated at least once a year, or more often if moved; the scale is tared to zero grams or 0.00 kg; AND the birth weight recorded is less than 2500 grams; OR second, a birth weight is recorded as less than 2500 grams as assessed per the health care facility's standard operating procedure, which fulfills criteria 1 to 4 of diagnostic level of certainty two.	Level 2 Low Birth Weight		Level 2 Low Birth Weight is defined by either one of the following two criteria: first, a newborn infant is weighed within 24 hours of birth; either an electronic or a spring scale that is graduated to 50 grams is used; the scale is calibrated at least once a year, or more often if moved; the scale is tared to zero grams or 0.00 kg; AND the birth weight recorded is less than 2500 grams; OR second, a birth weight is recorded as less than 2500 grams as assessed per the health care facility's standard operating procedure, which fulfills criteria 1 to 4 of diagnostic level of certainty two.	C128701	GAIA Low Birth Weight Level of Diagnostic Certainty Terminology
C127958	GAIA Level 2 Major External Structural Defect	GAIA Level 2 Major External Structural Defect is defined by four criteria: first, the defects are of a prenatal origin; second, at least one of the following requirements must be met: a) Alterations in the external anatomy that are present and visible at the time of live birth, and that persist beyond the immediate peripartum period unless surgically repaired OR b) Alterations in the external anatomy that are present and visible in a stillbirth or in the products of conception of a spontaneous or therapeutic abortion; third, the defect(s) affect (or have the propensity to affect) the health, survival, or physical or cognitive functioning of the individual; fourth,  there must be documented confirmation of a diagnosis made by a clinician with some experience diagnosing congenital anomalies.	Level 2 Major External Structural Defect		Level 2 Major External Structural Defect is defined by four criteria: first, the defects are of a prenatal origin; second, at least one of the following requirements must be met: a) Alterations in the external anatomy that are present and visible at the time of live birth, and that persist beyond the immediate peripartum period unless surgically repaired OR b) Alterations in the external anatomy that are present and visible in a stillbirth or in the products of conception of a spontaneous or therapeutic abortion; third, the defect(s) affect (or have the propensity to affect) the health, survival, or physical or cognitive functioning of the individual; fourth,  there must be documented confirmation of a diagnosis made by a clinician with some experience diagnosing congenital anomalies.	C126852	GAIA Major Congenital Anomalies Level of Diagnostic Certainty Terminology
C127966	GAIA Level 2 Major Functional Defect	GAIA Level 2 Major Functional Defect is defined by two criteria: first, at least one of the following requirements must be met: a) For live births, there must be alterations in the functioning of one or more organs or body parts that are not due to a structural defect, that are present at live birth (or propensity to develop alteration present at live birth), and that persist beyond the immediate peripartum period, unless treated through gene therapy or stem cell transplantation; OR b) For stillbirths or for spontaneous or therapeutic abortions, there must be alterations in the function of one or more organs or body parts that are not due to a structural defect; second, there must be documented confirmation of a diagnosis made by a clinician who is experienced in diagnosing congenital anomalies, and who has the highest level of training in the diagnosis of functional defects for the specific setting.	Level 2 Major Functional Defect		Level 2 Major Functional Defect is defined by two criteria: first, at least one of the following requirements must be met: a) For live births, there must be alterations in the functioning of one or more organs or body parts that are not due to a structural defect, that are present at live birth (or propensity to develop alteration present at live birth), and that persist beyond the immediate peripartum period, unless treated through gene therapy or stem cell transplantation; OR b) For stillbirths or for spontaneous or therapeutic abortions, there must be alterations in the function of one or more organs or body parts that are not due to a structural defect; second, there must be documented confirmation of a diagnosis made by a clinician who is experienced in diagnosing congenital anomalies, and who has the highest level of training in the diagnosis of functional defects for the specific setting.	C126852	GAIA Major Congenital Anomalies Level of Diagnostic Certainty Terminology
C127962	GAIA Level 2 Major Internal Structural Defect	GAIA Level 2 Major Internal Structural Defect is defined by three criteria: first, the defects are prenatal in origin; second, the defect(s) affect (or have the propensity to affect) the health, survival, or physical or cognitive functioning of the individual; third, one of the following requirements must be met: a) For a live birth, alterations in the internal anatomy must be present at the time of live birth, must persist beyond the immediate peripartum period unless surgically repaired, and require documented confirmation of a diagnosis made by a clinician who is experienced in diagnosing congenital anomalies, and who has the highest level of morphology training for the specific setting without using definitive imaging or intraoperative evaluation; OR b) For a stillbirth, or for a spontaneous or therapeutic abortion, an internal structural defect is visible prenatally either by ultrasound or by other imaging modality.	Level 2 Major Internal Structural Defect		Level 2 Major Internal Structural Defect is defined by three criteria: first, the defects are prenatal in origin; second, the defect(s) affect (or have the propensity to affect) the health, survival, or physical or cognitive functioning of the individual; third, one of the following requirements must be met: a) For a live birth, alterations in the internal anatomy must be present at the time of live birth, must persist beyond the immediate peripartum period unless surgically repaired, and require documented confirmation of a diagnosis made by a clinician who is experienced in diagnosing congenital anomalies, and who has the highest level of morphology training for the specific setting without using definitive imaging or intraoperative evaluation; OR b) For a stillbirth, or for a spontaneous or therapeutic abortion, an internal structural defect is visible prenatally either by ultrasound or by other imaging modality.	C126852	GAIA Major Congenital Anomalies Level of Diagnostic Certainty Terminology
C127998	GAIA Level 2 Maternal Death	GAIA Level 2 Maternal Death is defined by three criteria: first, diagnosis of a pregnancy, in the absence of level 1 criteria, as established by either of the following requirements: a) last menstrual period date; b) Serial symphysio fundal height examinations; second, death of the mother while pregnant or within 42 days of termination of pregnancy, irrespective of the duration and the site of the pregnancy; third, documentation of the maternal cause of death wherein one of the following requirements must be met: a) Direct: abortive outcome, hypertensive disorder, obstetric hemorrhage, pregnancy related infection, other obstetric complications, unanticipated complications; b) Indirect: non obstetric complications; c) Death during pregnancy, childbirth, and the puerperium: other or coincidental; d) Unspecified: unknown or undetermined.	Level 2 Maternal Death		Level 2 Maternal Death is defined by three criteria: first, diagnosis of a pregnancy, in the absence of level 1 criteria, as established by either of the following requirements: a) last menstrual period date; b) Serial symphysio fundal height examinations; second, death of the mother while pregnant or within 42 days of termination of pregnancy, irrespective of the duration and the site of the pregnancy; third, documentation of the maternal cause of death wherein one of the following requirements must be met: a) Direct: abortive outcome, hypertensive disorder, obstetric hemorrhage, pregnancy related infection, other obstetric complications, unanticipated complications; b) Indirect: non obstetric complications; c) Death during pregnancy, childbirth, and the puerperium: other or coincidental; d) Unspecified: unknown or undetermined.	C126858	GAIA Maternal Death Level of Diagnostic Certainty Terminology
C127982	GAIA Level 2 Maternal Immunization	GAIA Level 2 Maternal immunization is defined by three criteria: first, pregnancy must be confirmed by both the patient's report of cessation of menstrual period and by physical exam revealing a gravid uterus; second, the date (at least month and year) of the immunization of the pregnant woman must be recorded in the medical records by the health care worker who administered/witnessed administration of vaccine; third, the medical record must contain details of the disease against which the individual was vaccinated.	Level 2 Maternal Immunisation		Level 2 Maternal immunization is defined by three criteria: first, pregnancy must be confirmed by both the patient's report of cessation of menstrual period and by physical exam revealing a gravid uterus; second, the date (at least month and year) of the immunization of the pregnant woman must be recorded in the medical records by the health care worker who administered/witnessed administration of vaccine; third, the medical record must contain details of the disease against which the individual was vaccinated.	C126853	GAIA Neonatal Death Level of Diagnostic Certainty Terminology
C128745	GAIA Level 2 Morbidly Adherent Placentation	GAIA Level 2 Morbidly Adherent Placentation is defined by two criteria: first, ultrasound evidence of placenta previa; second, hypervascularity of the lower uterine segment, diagnosed during a laparotomy. Alternatively, Level 2 may be defined as difficulty with placental separation after delivery of the infant, during either a vaginal or a cesarean delivery, with resultant hemorrhage due to partial separation.	Level 2 Morbidly Adherent Placentation		Level 2 Morbidly Adherent Placentation is defined by two criteria: first, ultrasound evidence of placenta previa; second, hypervascularity of the lower uterine segment, diagnosed during a laparotomy. Alternatively, Level 2 may be defined as difficulty with placental separation after delivery of the infant, during either a vaginal or a cesarean delivery, with resultant hemorrhage due to partial separation.	C128706	GAIA Antenatal Bleeding Level of Diagnostic Certainty Terminology
C127970	GAIA Level 2 Neonatal Death in a Non-viable Live Birth	GAIA Level 2 Neonatal Death in a Non-viable Live Birth is defined by three criteria: first, the infant must be live born; second, at least one of the following requirements must be met: a) Gestational age less than 22 weeks (where the GA level of certainty is either level one or level two) OR b) Birth weight less than 500g; third, the death of the infant within the first 28 days of life must be documented.	Level 2 Neonatal Death in a Non-viable Live Birth		Level 2 Neonatal Death in a Non-viable Live Birth is defined by three criteria: first, the infant must be live born; second, at least one of the following requirements must be met: a) Gestational age less than 22 weeks (where the GA level of certainty is either level one or level two) OR b) Birth weight less than 500g; third, the death of the infant within the first 28 days of life must be documented.	C126853	GAIA Neonatal Death Level of Diagnostic Certainty Terminology
C127976	GAIA Level 2 Neonatal Death in a Preterm Live Birth	GAIA Level 2 Neonatal Death in a Preterm Live Birth is defined by three criteria: first, the infant must be live born; second, at least one of the following requirements must be met: a) Gestational age greater than or equal to 28 and less than 37 weeks (where the GA level of certainty is either level one or level two); OR b) Birth weight greater than or equal to 1000g but less than 2500g; third, the death of the infant within the first 28 days of life must be documented.	Level 2 Neonatal Death in a Preterm Live Birth		Level 2 Neonatal Death in a Preterm Live Birth is defined by three criteria: first, the infant must be live born; second, at least one of the following requirements must be met: a) Gestational age greater than or equal to 28 and less than 37 weeks (where the GA level of certainty is either level one or level two); OR b) Birth weight greater than or equal to 1000g but less than 2500g; third, the death of the infant within the first 28 days of life must be documented.	C126853	GAIA Neonatal Death Level of Diagnostic Certainty Terminology
C127979	GAIA Level 2 Neonatal Death in a Term Live Birth	GAIA Level 2 Neonatal Death in a Term Live Birth is defined by three criteria: first, the infant must be live born; second, at least one of the following requirements must be met: a) Gestational age greater than or equal to 37 weeks (where the GA level of certainty is either level one or level two) OR b) Birth weight greater than or equal to 2500g; third, the death of the infant within the first 28 days of life must be documented.	Level 2 Neonatal Death in a Term Live Birth		Level 2 Neonatal Death in a Term Live Birth is defined by three criteria: first, the infant must be live born; second, at least one of the following requirements must be met: a) Gestational age greater than or equal to 37 weeks (where the GA level of certainty is either level one or level two) OR b) Birth weight greater than or equal to 2500g; third, the death of the infant within the first 28 days of life must be documented.	C126853	GAIA Neonatal Death Level of Diagnostic Certainty Terminology
C127973	GAIA Level 2 Neonatal Death in an Extremely Preterm Live Birth	GAIA Level 2 Neonatal Death in an Extremely Preterm Live Birth is defined by three criteria: first, the infant must be live born; second, at least one of the following requirements must be met: a) Gestational age greater than or equal to 22 and less than 28 weeks (where the GA level of certainty is either level one or level two) OR b) Birth weight greater than or equal to 500g but less than 1000g; third, the death of the infant within the first 28 days of life must be documented.	Level 2 Neonatal Death in an Extremely Preterm Live Birth		Level 2 Neonatal Death in an Extremely Preterm Live Birth is defined by three criteria: first, the infant must be live born; second, at least one of the following requirements must be met: a) Gestational age greater than or equal to 22 and less than 28 weeks (where the GA level of certainty is either level one or level two) OR b) Birth weight greater than or equal to 500g but less than 1000g; third, the death of the infant within the first 28 days of life must be documented.	C126853	GAIA Neonatal Death Level of Diagnostic Certainty Terminology
C128730	GAIA Level 2 Neonatal Encephalopathy	GAIA Level 2 Neonatal Encephalopathy is defined by three criteria: first, a newborn infant (1 to 28 days of life) born at or beyond 35 weeks of gestation; second, an abnormal level of alertness or seizures; third, either difficulty with initiating and maintaining respiration OR depression of muscle tone.	Level 2 Neonatal Encephalopathy		Level 2 Neonatal Encephalopathy is defined by three criteria: first, a newborn infant (1 to 28 days of life) born at or beyond 35 weeks of gestation; second, an abnormal level of alertness or seizures; third, either difficulty with initiating and maintaining respiration OR depression of muscle tone.	C128699	GAIA Neonatal Encephalopathy Level of Diagnostic Certainty Terminology
C127988	GAIA Level 2 Neonatal Infectious Meningitis	GAIA Level 2 Neonatal Infectious Meningitis is defined by four criteria: first, CSF pleocytosis OR positive IgM antibodies to a specific pathogen in the CSF; second, a recognized pathogen is identified, using a validated method from a normally sterile site other than the CSF; third, a temperature greater than or equal to 37.5 degrees C or less than 35.5 degrees C; fourth, one or more of the following requirements must be met: a) History of convulsions; b) Lethargy or irritability; c) Coma; d) Apnea; e) Bulging fontanel; f) Neck stiffness.	Level 2 Neonatal Meningitis		Level 2 Neonatal Infectious Meningitis is defined by four criteria: first, CSF pleocytosis OR positive IgM antibodies to a specific pathogen in the CSF; second, a recognized pathogen is identified, using a validated method from a normally sterile site other than the CSF; third, a temperature greater than or equal to 37.5 degrees C or less than 35.5 degrees C; fourth, one or more of the following requirements must be met: a) History of convulsions; b) Lethargy or irritability; c) Coma; d) Apnea; e) Bulging fontanel; f) Neck stiffness.	C126854	GAIA Neonatal Infections Level of Diagnostic Certainty Terminology
C127985	GAIA Level 2 Neonatal Invasive Bloodstream Infection	GAIA Level 2 Neonatal Invasive Bloodstream Infection is defined by two criteria: first, the criteria does not meet the requirements for level 1 diagnostic certainty; second, three or more of the following requirements must be met: a) Temperature greater than or equal to 37.5 degrees C or less than 35.5 degrees C; b) Tachycardia or new or more frequent episodes of bradycardia; c) New or more frequent episodes of apnea or increased oxygen requirement or increased requirement for ventilatory support; d) Lethargy or moving only when stimulated or hypotonia or irritability; e) Difficulty in feeding or abdominal distention; f) Pallor or poor perfusion or hypotension; g) Abnormal white cell count or I/T (immature/total neutrophil) ratio greater than 0.2; h) Abnormal platelet count; i) Increased number of inflammatory markers (CRP, procalcitonin); j) Metabolic acidosis as defined by a base excess.	Level 2 Neonatal Blood Stream Infection		Level 2 Neonatal Invasive Blood Stream Infection is defined by two criteria: first, the criteria does not meet the requirements for level 1 diagnostic certainty; second, three or more of the following requirements must be met: a) Temperature greater than or equal to 37.5 degrees C or less than 35.5 degrees C; b) Tachycardia or new or more frequent episodes of bradycardia; c) New or more frequent episodes of apnea or increased oxygen requirement or increased requirement for ventilatory support; d) Lethargy or moving only when stimulated or hypotonia or irritability; e) Difficulty in feeding or abdominal distention; f) Pallor or poor perfusion or hypotension; g) Abnormal white cell count or I/T (immature/total neutrophil) ratio greater than 0.2; h) Abnormal platelet count; i) Increased number of inflammatory markers (CRP, procalcitonin); j) Metabolic acidosis as defined by a base excess.	C126854	GAIA Neonatal Infections Level of Diagnostic Certainty Terminology
C128769	GAIA Level 2 Neonatal Respiratory Distress	GAIA Level 2 Neonatal Respiratory Distress is defined by four criteria: first, the newborn must be between 0 and 28 days of life; second, an abnormal respiratory rate (not measured, but reported as "rapid breathing", "slow breathing", having periods of "no breathing", or "abnormal breathing"); third, the presence of any one of the following five clinical symptoms that indicate labored breathing: a) Nasal flaring (dilatation of alae nasi); b) Noisy respirations in the form of expiratory grunting, stridor, or wheeze; c) Retractions or increased chest indrawings on inspiration (subcostal, intercostal, sternal, suprasternal notch) or seesaw respirations; d) Central cyanosis (whole body, including lips and tongue) on room air; e) Low Apgar score (less than 7 points) at 10 minutes with a respiration score less than 2; fourth, one of the following two requirements: a) No medical record documentation, but reporting through either a non-medical observer (e.g., mother, father, community worker) or via standard census mechanisms (e.g., Demographic and Health Surveillance System), or b) Collection of information from medical review or billing codes.	Level 2 Neonatal Respiratory Distress		Level 2 Neonatal Respiratory Distress is defined by four criteria: first, the newborn must be between 0 and 28 days of life; second, an abnormal respiratory rate (not measured, but reported as "rapid breathing", "slow breathing", having periods of "no breathing", or "abnormal breathing"); third, the presence of any one of the following five clinical symptoms that indicate labored breathing: a) Nasal flaring (dilatation of alae nasi); b) Noisy respirations in the form of expiratory grunting, stridor, or wheeze; c) Retractions or increased chest indrawings on inspiration (subcostal, intercostal, sternal, suprasternal notch) or seesaw respirations; d) Central cyanosis (whole body, including lips and tongue) on room air; e) Low Apgar score (less than 7 points) at 10 minutes with a respiration score less than 2; fourth, one of the following two requirements: a) No medical record documentation, but reporting through either a non-medical observer (e.g., mother, father, community worker) or via standard census mechanisms (e.g., Demographic and Health Surveillance System), or b) Collection of information from medical review or billing codes.	C128702	GAIA Neonatal Respiratory Distress Level of Diagnostic Certainty Terminology
C127992	GAIA Level 2 Neonatal Respiratory Tract Infection	GAIA Level 2 Neonatal Respiratory Tract Infection is defined by two criteria: first, new or progressive or persistent infiltrate or shadowing or fluid in the intrapleural cavity or interlobar fissure on chest X-ray; second, four or more of the following requirements must be met: a) Temperature greater than or equal to 37.5 degrees C or less than 35.5 degrees C; b) Tachypnea or nasal flaring or chest indrawing or grunting; c) Desaturations or increased oxygen requirements or increased ventilator requirements or oxygen saturation less than 95%; d) Apnea; e) Increased respiratory secretions or increased suctioning requirements; f) Cough, wheeze, or crepitations; g) Increased CRP or procalcitonin.	Level 2 Neonatal Respiratory Tract Infection		Level 2 Neonatal Respiratory Tract Infection is defined by two criteria: first, new or progressive or persistent infiltrate or shadowing or fluid in the intrapleural cavity or interlobar fissure on chest X-ray; second, four or more of the following requirements must be met: a) Temperature greater than or equal to 37.5 degrees C or less than 35.5 degrees C; b) Tachypnea or nasal flaring or chest indrawing or grunting; c) Desaturations or increased oxygen requirements or increased ventilator requirements or oxygen saturation less than 95%; d) Apnea; e) Increased respiratory secretions or increased suctioning requirements; f) Cough, wheeze, or crepitations; g) Increased CRP or procalcitonin.	C126854	GAIA Neonatal Infections Level of Diagnostic Certainty Terminology
C127995	GAIA Level 2 Non-reassuring Fetal Status	GAIA Level 2 Non-reassuring Fetal Status is defined by the presence of at least one of the following two criteria: first, a category III fetal heart rate tracing detected via continuous cardiotocography as defined by NICHD; second, one of the following two conditions must be met: a) an absent baseline fetal heart rate variability AND any of the following: recurrent late decelerations, recurrent variable deceleration, bradycardia (less than 110 bpm); OR b) a sinusoidal pattern.	Level 2 Non-reassuring Fetal Status		Level 2 Non-reassuring Fetal Status is defined by the presence of at least one of the following two criteria: first, a category III fetal heart rate tracing detected via continuous cardiotocography as defined by NICHD; second, one of the following two conditions must be met: a) an absent baseline fetal heart rate variability AND any of the following: recurrent late decelerations, recurrent variable deceleration, bradycardia (less than 110 bpm); OR b) a sinusoidal pattern.	C126857	GAIA Non-Reassuring Fetal Status Level of Diagnostic Certainty Terminology
C128743	GAIA Level 2 Placenta Previa	GAIA Level 2 Placenta Previa is defined by three criteria: first, painless vaginal bleeding during the second or third trimester; second, a high presenting part or abnormal fetal lie; third, pelvic exam with fullness palpable in the fornices (avoiding digital cervical exam) OR a speculum exam with placental tissue visible through an open cervical os.	Level 2 Placenta Previa		Level 2 Placenta Previa is defined by three criteria: first, painless vaginal bleeding during the second or third trimester; second, a high presenting part or abnormal fetal lie; third, pelvic exam with fullness palpable in the fornices (avoiding digital cervical exam) OR a speculum exam with placental tissue visible through an open cervical os.	C128706	GAIA Antenatal Bleeding Level of Diagnostic Certainty Terminology
C128749	GAIA Level 2 Placental Abruption	GAIA Level 2 Placental Abruption is defined by two criteria: first, vaginal bleeding during the second or third trimester; second, uterine irritability (irregular, frequent uterine activity, not coalesced into clear contractions in a regular pattern) or labor without clinical signs of hypovolemic shock or coagulopathy. Alternatively, Level 2 may be defined as vaginal bleeding during the second or third trimester with clinical evidence of retroplacental clot or visually evident placental infarcts at the time of delivery.	Level 2 Placental Abruption		Level 2 Placental Abruption is defined by two criteria: first, vaginal bleeding during the second or third trimester; second, uterine irritability (irregular, frequent uterine activity, not coalesced into clear contractions in a regular pattern) or labor without clinical signs of hypovolemic shock or coagulopathy. Alternatively, Level 2 may be defined as vaginal bleeding during the second or third trimester with clinical evidence of retroplacental clot or visually evident placental infarcts at the time of delivery.	C128706	GAIA Antenatal Bleeding Level of Diagnostic Certainty Terminology
C128001	GAIA Level 2 Postpartum Hemorrhage	GAIA Level 2 Postpartum Hemorrhage is defined by the presence of the following criteria: genital bleeding after delivery with at least one of the following: a) Measured abnormal bleeding (1000ml or more); or b) Any bleeding leading to hypotension or blood transfusion.	Level 2 Postpartum Haemorrhage		Level 2 Postpartum Hemorrhage is defined by the presence of the following criteria: genital bleeding after delivery with at least one of the following: a) Measured abnormal bleeding (1000ml or more); or b) Any bleeding leading to hypotension or blood transfusion.	C126859	GAIA Postpartum Hemorrhage Level of Diagnostic Certainty Terminology
C128004	GAIA Level 2 Preeclampsia	GAIA Level 2 Preeclampsia is defined by three criteria: first, the gestational age of the pregnancy must be greater than or equal to 20 weeks; second, a diagnosis of new onset maternal hypertension (systolic blood pressure greater than or equal to 140mmHg and/or diastolic blood pressure greater than or equal to 90mmHg) that is sustained on two measurements for a minimum of one hour; third, a diagnosis of new onset proteinuria that is a level 2 diagnostic certainty (proteinuria diagnosed with greater than or equal to 1+ protein on urine dipstick).	Level 2 Preeclampsia		Level 2 Preeclampsia is defined by three criteria: first, the gestational age of the pregnancy must be greater than or equal to 20 weeks; second, a diagnosis of new onset maternal hypertension (systolic blood pressure greater than or equal to 140mmHg and/or diastolic blood pressure greater than or equal to 90mmHg) that is sustained on two measurements for a minimum of one hour; third, a diagnosis of new onset proteinuria that is a level 2 diagnostic certainty (proteinuria diagnosed with greater than or equal to 1+ protein on urine dipstick).	C126860	GAIA Preeclampsia Level of Diagnostic Certainty Terminology
C128007	GAIA Level 2 Preeclampsia with Severe Features	GAIA Level 2 Preeclampsia with Severe Features is defined by three criteria: first, the gestational age of the pregnancy must be greater than or equal to 20 weeks; second, a diagnosis of new onset maternal hypertension (systolic blood pressure greater than or equal to 140mmHg and/or diastolic blood pressure greater than or equal to 90mmHg) that is sustained on two measurements for a minimum of one hour; third, the diagnosis of new onset nausea and vomiting.	Level 2 Preeclampsia with Severe Features		Level 2 Preeclampsia with Severe Features is defined by three criteria: first, the gestational age of the pregnancy must be greater than or equal to 20 weeks; second, a diagnosis of new onset maternal hypertension (systolic blood pressure greater than or equal to 140mmHg and/or diastolic blood pressure greater than or equal to 90mmHg) that is sustained on two measurements for a minimum of one hour; third, the diagnosis of new onset nausea and vomiting.	C126860	GAIA Preeclampsia Level of Diagnostic Certainty Terminology
C128764	GAIA Level 2 Prenatally Diagnosed Congenital Microcephaly	GAIA Level 2 Prenatally Diagnosed Congenital Microcephaly is defined by three criteria: first, the fetus is at least 24 weeks gestational age (GA) based on last menstrual period (LMP) date with fundal height and no confirmatory first or second trimester ultrasound (US) scan; second, a head circumference (HC) measurement either 2 standard deviations (SD) below the mean or less than the third percentile according to fetal US examination, using appropriate, standardized reference charts according to GA and gender for the population (e.g. WHO growth reference charts if GA greater than or equal to 37 weeks and Intergrowth-21st reference charts for GA 24 to 36 weeks) with femur length and abdominal circumference concordant with GA assessment; third, confirmation of microcephaly (i.e., HC 2 SD below the mean or less than 3%) in the fetus by either at least one additional US after 24 weeks that occurs at least one week after the first US, OR confirmation of microcephaly by HC measurement with a standard tape measure at either birth or autopsy.	Level 2 Prenatally Diagnosed Congenital Microcephaly		Level 2 Prenatally Diagnosed Congenital Microcephaly is defined by three criteria: first, the fetus is at least 24 weeks gestational age (GA) based on last menstrual period (LMP) date with fundal height and no confirmatory first or second trimester ultrasound (US) scan; second, a head circumference (HC) measurement either 2 standard deviations (SD) below the mean or less than the third percentile according to fetal US examination, using appropriate, standardized reference charts according to GA and gender for the population (e.g. WHO growth reference charts if GA greater than or equal to 37 weeks and Intergrowth-21st reference charts for GA 24 to 36 weeks) with femur length and abdominal circumference concordant with GA assessment; third, confirmation of microcephaly (i.e., HC 2 SD below the mean or less than 3%) in the fetus by either at least one additional US after 24 weeks that occurs at least one week after the first US, OR confirmation of microcephaly by HC measurement with a standard tape measure at either birth or autopsy.	C128700	GAIA Congenital Microcephaly Level of Diagnostic Certainty Terminology
C128782	GAIA Level 2 Second Trimester Spontaneous Abortion	GAIA Level 2 Second Trimester Spontaneous Abortion is defined by three criteria: first, it does not qualify as a Level 1 Second Trimester Spontaneous Abortion; second, gestational age is within the pre-defined range for the selected abortion definition as assessed by maternal and/or fetal parameters (Level 3) (Brighton Preterm Birth Gestational Age algorithm); third, one of the following three requirements must be met: a) No visible heartbeat on ultrasound; b) Visible expulsion of pregnancy tissues/products of conception on examination of the cervix; c) Products of conception found on histopathological evaluation of uterine contents.	Level 2 Second Trimester Spontaneous Abortion		Level 2 Second Trimester Spontaneous Abortion is defined by three criteria: first, it does not qualify as a Level 1 Second Trimester Spontaneous Abortion; second, gestational age is within the pre-defined range for the selected abortion definition as assessed by maternal and/or fetal parameters (Level 3) (Brighton Preterm Birth Gestational Age algorithm); third, one of the following three requirements must be met: a) No visible heartbeat on ultrasound; b) Visible expulsion of pregnancy tissues/products of conception on examination of the cervix; c) Products of conception found on histopathological evaluation of uterine contents.	C128705	GAIA Spontaneous Abortion and Ectopic Pregnancy Level of Diagnostic Certainty Terminology
C128747	GAIA Level 2 Vasa Previa	GAIA Level 2 Vasa Previa is defined by four criteria: first, vaginal bleeding during the second or third trimester at the time of ruptured amniotic membranes; second, fetal heart rate changes ultimately resulting in sinusoidal rhythm/terminal bradycardia; third, delivery of one of the following: a) a pale, anemic infant; OR b) a recent stillbirth; OR c) a neonatal death; fourth, post-delivery examination of the placental specimen that demonstrates unsupported fetal vessels within the membranes.	Level 2 Vasa Previa		Level 2 Vasa Previa is defined by four criteria: first, vaginal bleeding during the second or third trimester at the time of ruptured amniotic membranes; second, fetal heart rate changes ultimately resulting in sinusoidal rhythm/terminal bradycardia; third, delivery of one of the following: a) a pale, anemic infant; OR b) a recent stillbirth; OR c) a neonatal death; fourth, post-delivery examination of the placental specimen that demonstrates unsupported fetal vessels within the membranes.	C128706	GAIA Antenatal Bleeding Level of Diagnostic Certainty Terminology
C128014	GAIA Level 2a Assessment of Gestational Age	GAIA Level 2a Assessment of Gestational Age is defined by the presence of at least one of the following criteria: a) Certain last menstrual period (LMP) date with second trimester scan (14 0/7 weeks to 27 6/7 weeks), (If LMP and ultrasound (U/S) do not correlate, default to U/S GA assessment); OR b) Certain LMP date with first trimester physical examination.	Level 2a Assessment of Prematurity and Gestational Age		Level 2a Assessment of Gestational Age is defined by the presence of at least one of the following criteria: a) Certain last menstrual period (LMP) date with second trimester scan (14 0/7 weeks to 27 6/7 weeks), (If LMP and ultrasound (U/S) do not correlate, default to U/S GA assessment); OR b) Certain LMP date with first trimester physical examination.	C126855	GAIA Preterm Birth Level of Diagnostic Certainty Terminology
C128771	GAIA Level 2a Failure to Thrive	GAIA Level 2a Failure to Thrive is defined by either of two criteria: first, the following four requirements must be present: a) Infant age determined by a documented birth date; b) Weights are obtained using a beam balance scale; c) A minimum of two documented weights measured at least four weeks apart; d) Weight for age deceleration must pass through at least two centile spaces on a growth chart; OR second, the following four requirements must be present: a) Infants have an undocumented birth date, where age is determined based on mother's recall to the nearest month; b) Weights are obtained using an electronic scale; c) A minimum of two weights measured at least four weeks apart; d) Weight for age deceleration must pass through at least two centile spaces on a growth chart.	Level 2a Failure to Thrive		Level 2a Failure to Thrive is defined by either of two criteria: first, the following four requirements must be present: a) Infant age determined by a documented birth date; b) Weights are obtained using a beam balance scale; c) A minimum of two documented weights measured at least four weeks apart; d) Weight for age deceleration must pass through at least two centile spaces on a growth chart; OR second, the following four requirements must be present: a) Infants have an undocumented birth date, where age is determined based on mother's recall to the nearest month; b) Weights are obtained using an electronic scale; c) A minimum of two weights measured at least four weeks apart; d) Weight for age deceleration must pass through at least two centile spaces on a growth chart.	C128704	GAIA Failure to Thrive Level of Diagnostic Certainty Terminology
C128723	GAIA Level 2a Fetal Growth Restriction	GAIA Level 2a Fetal Growth Restriction is defined by two criteria: first, Level 2 evidence of pregnancy dating; second, at least one of the following requirements must be met: a) Estimated fetal weight below the third percentile using locally-accepted growth curve; OR b) Estimated fetal weight below the tenth percentile using locally-accepted growth curve AND either findings of absent or reversed end-diastolic flow of the umbilical artery Doppler OR a finding of oligohydramnios.	Level 2a Fetal Growth Restriction		Level 2a Fetal Growth Restriction is defined by two criteria: first, Level 2 evidence of pregnancy dating; second, at least one of the following requirements must be met: a) Estimated fetal weight below the third percentile using locally-accepted growth curve; OR b) Estimated fetal weight below the tenth percentile using locally-accepted growth curve AND either findings of absent or reversed end-diastolic flow of the umbilical artery Doppler OR a finding of oligohydramnios.	C128708	GAIA Fetal Growth Restriction Level of Diagnostic Certainty Terminology
C128758	GAIA Level 2a Postnatally Diagnosed Congenital Microcephaly	GAIA Level 2a Postnatally Diagnosed Congenital Microcephaly is defined by three criteria: first, a live birth, stillbirth, or spontaneous or therapeutic abortion of at least 24 weeks gestational age (GA), with GA assessed by either a certain last menstrual period (LMP) date with confirmatory 1st trimester (less than 14 weeks) or 2nd trimester ultrasound (US) scan OR intrauterine insemination (IUI) OR embryo transfer date; second, a head circumference (HC) measurement either 2 standard deviations (SD) below the mean or less than the third percentile as assessed by GA and gender, using appropriate, standardized reference charts for the population (e.g. WHO growth reference charts if GA greater than or equal to 37 weeks and Intergrowth-21st reference charts for GA 24 to 36 weeks); third, one of the following requirements is met: a) the measurement is taken within the first 24 hours after birth or at the end of the pregnancy taking into consideration the molding of the head; OR b) the measurement is taken greater than 36 hours and up to 6 weeks after birth or the end of the pregnancy with no apparent post-natal insult resulting in microcephaly.	Level 2a Postnatally Diagnosed Congenital Microcephaly		Level 2a Postnatally Diagnosed Congenital Microcephaly is defined by three criteria: first, a live birth, stillbirth, or spontaneous or therapeutic abortion of at least 24 weeks gestational age (GA), with GA assessed by either a certain last menstrual period (LMP) date with confirmatory 1st trimester (less than 14 weeks) or 2nd trimester ultrasound (US) scan OR intrauterine insemination (IUI) OR embryo transfer date; second, a head circumference (HC) measurement either 2 standard deviations (SD) below the mean or less than the third percentile as assessed by GA and gender, using appropriate, standardized reference charts for the population (e.g. WHO growth reference charts if GA greater than or equal to 37 weeks and Intergrowth-21st reference charts for GA 24 to 36 weeks); third, one of the following requirements is met: a) the measurement is taken within the first 24 hours after birth or at the end of the pregnancy taking into consideration the molding of the head; OR b) the measurement is taken greater than 36 hours and up to 6 weeks after birth or the end of the pregnancy with no apparent post-natal insult resulting in microcephaly.	C128700	GAIA Congenital Microcephaly Level of Diagnostic Certainty Terminology
C128734	GAIA Level 2a Small for Gestational Age	GAIA Level 2a Small for Gestational Age is defined by three criteria: first, weight below the 10th percentile for gestational age; second, newborn weighed within 24 hours of birth on any scale with a less than or equal to 50 g resolution, calibrated and tared to zero; third, the gestational age is assessed by either a) Certain LMP with first or second trimester ultrasound; or b) Certain LMP with first trimester physical exam.	Level 2a Small for Gestational Age		Level 2a Small for Gestational Age is defined by three criteria: first, weight below the 10th percentile for gestational age; second, newborn weighed within 24 hours of birth on any scale with a less than or equal to 50 g resolution, calibrated and tared to zero; third, the gestational age is assessed by either a) Certain LMP with first or second trimester ultrasound; or b) Certain LMP with first trimester physical exam.	C128703	GAIA Small for Gestational Age Level of Diagnostic Certainty Terminology
C128015	GAIA Level 2b Assessment of Gestational Age	GAIA Level 2b Assessment of Gestational Age is defined by the following criteria: uncertain last menstrual period (LMP) date with second trimester scan (14 0/7 weeks to 27 6/7 weeks).	Level 2b Assessment of Prematurity and Gestational Age		Level 2b Assessment of Gestational Age is defined by the following criteria: uncertain last menstrual period (LMP) date with second trimester scan (14 0/7 weeks to 27 6/7 weeks).	C126855	GAIA Preterm Birth Level of Diagnostic Certainty Terminology
C128772	GAIA Level 2b Failure to Thrive	GAIA Level 2b Failure to Thrive is defined by either of two criteria: first, the following four requirements must be present: a) Infant age determined by a documented birth date; b) Weights are obtained using a spring balance scale; c) A minimum of two weights measured at least four weeks apart; d) Weight for age deceleration must pass through at least two centile spaces on a growth chart; OR second, the following three requirements must be present: a) Weight is measured using an electronic scale or beam balance scale; b) Length is documented using infantometer; c) Weight for length ratio less than or equal to the third centile on an appropriate growth chart.	Level 2b Failure to Thrive		Level 2b Failure to Thrive is defined by the following criteria: first, the following four requirements must be present: a) Infant age determined by a documented birth date; b) Weights are obtained using a spring balance scale; c) A minimum of two weights measured at least four weeks apart; d) Weight for age deceleration must pass through at least two centile spaces on a growth chart; OR second, the following three requirements must be present: a) Weight is measured using an electronic scale or beam balance scale; b) Length is documented using infantometer; c) Weight for length ratio less than or equal to the third centile on an appropriate growth chart.	C128704	GAIA Failure to Thrive Level of Diagnostic Certainty Terminology
C128724	GAIA Level 2b Fetal Growth Restriction	GAIA Level 2b Fetal Growth Restriction is defined by two criteria: first, Level 2 evidence of pregnancy dating; second, at least one of the following requirements must be met: a) Estimated fetal weight below the tenth percentile using locally-accepted growth curve AND either no findings of absent or reversed end-diastolic flow of the umbilical artery Doppler OR absence of oligohydramnios. Alternatively, Level 2b may be defined by the following two criteria: first, Level 1 evidence of pregnancy dating; second, an estimated fetal weight below the tenth percentile using locally-accepted growth curve, and absence of oligohydramnios with the inability to assess umbilical artery Doppler.	Level 2b Fetal Growth Restriction		Level 2b Fetal Growth Restriction is defined by two criteria: first, Level 2 evidence of pregnancy dating; second, at least one of the following requirements must be met: a) Estimated fetal weight below the tenth percentile using locally-accepted growth curve AND either no findings of absent or reversed end-diastolic flow of the umbilical artery Doppler OR absence of oligohydramnios. Alternatively, Level 2b may be defined by the following two criteria: first, Level 1 evidence of pregnancy dating; second, an estimated fetal weight below the tenth percentile using locally-accepted growth curve, and absence of oligohydramnios with the inability to assess umbilical artery Doppler.	C128708	GAIA Fetal Growth Restriction Level of Diagnostic Certainty Terminology
C128759	GAIA Level 2b Postnatally Diagnosed Congenital Microcephaly	GAIA Level 2b Postnatally Diagnosed Congenital Microcephaly is defined by three criteria: first, a live birth, stillbirth, or spontaneous or therapeutic abortion of at least 24 weeks gestational age (GA), with GA assessed based on uncertain LMP with 2nd trimester ultrasound (US) scan; second, a head circumference (HC) measurement either 2 standard deviations (SD) below the mean or less than the third percentile as assessed by GA and gender, using appropriate, standardized reference charts for the population (e.g. WHO growth reference charts if GA greater than or equal to 37 weeks and Intergrowth-21st reference charts for GA 24 to 36 weeks); third, one of the following requirements is met: a) the measurement is taken within the first 24 hours after birth or at the end of the pregnancy taking into consideration the molding of the head; OR b) the measurement is taken greater than 36 hours and up to 6 weeks after birth or the end of the pregnancy with no apparent post-natal insult resulting in microcephaly.	Level 2b Postnatally Diagnosed Congenital Microcephaly		Level 2b Postnatally Diagnosed Congenital Microcephaly is defined by three criteria: first, a live birth, stillbirth, or spontaneous or therapeutic abortion of at least 24 weeks gestational age (GA), with GA assessed based on uncertain LMP with 2nd trimester ultrasound (US) scan; second, a head circumference (HC) measurement either 2 standard deviations (SD) below the mean or less than the third percentile as assessed by GA and gender, using appropriate, standardized reference charts for the population (e.g. WHO growth reference charts if GA greater than or equal to 37 weeks and Intergrowth-21st reference charts for GA 24 to 36 weeks); third, one of the following requirements is met: a) the measurement is taken within the first 24 hours after birth or at the end of the pregnancy taking into consideration the molding of the head; OR b) the measurement is taken greater than 36 hours and up to 6 weeks after birth or the end of the pregnancy with no apparent post-natal insult resulting in microcephaly.	C128700	GAIA Congenital Microcephaly Level of Diagnostic Certainty Terminology
C128735	GAIA Level 2b Small for Gestational Age	GAIA Level 2b Small for Gestational Age is defined by three criteria: first, weight below the 10th percentile for gestational age; second, the newborn weighed within 24 hours on any scale with a less than or equal to 50 g resolution, calibrated and tared to zero; third, gestational age determined by uncertain LMP with second trimester ultrasound.	Level 2b Small for Gestational Age		Level 2b Small for Gestational Age is defined by three criteria: first, weight below the 10th percentile for gestational age; second, the newborn weighed within 24 hours on any scale with a less than or equal to 50 g resolution, calibrated and tared to zero; third, gestational age determined by uncertain LMP with second trimester ultrasound.	C128703	GAIA Small for Gestational Age Level of Diagnostic Certainty Terminology
C128020	GAIA Level 3 Antepartum Stillbirth	GAIA Level 3 Antepartum Stillbirth is defined by three criteria: first, delivery of an infant with no signs of life at birth, including the following: no spontaneous movements, no umbilical cord pulse, no heartbeat, no crying, no spontaneous respirations or chest movement, and full body cyanosis; second, one or more of the following three requirements must be met: a) Maternal report of the absence of fetal movement for 24 hours or more prior to delivery; b) Report of auscultation for fetal heart tones using electronic devices (e.g. handheld Doppler or fetal heart rate monitor) or non-electronic devices (e.g. stethoscope, fetoscope or Pinard horn) that documents the absence of a fetal heartbeat; c) Non-attended delivery followed by a post-delivery physical examination of the fetus that is performed by a health care professional who meets the standard of care in the immediate health care setting, and that is consistent with antepartum death; d) a verbal history provided by a trained health care provider, non-medical witness, or the mother of the fetus documenting that the fetus was born with no signs of life, was unresponsive to resuscitation efforts immediately after delivery, and had physical features consistent with antepartum death; third, gestational age within the pre-defined range for selected stillbirth definition as assessed by maternal and/or fetal parameters.	Level 3 Antepartum Stillbirth		Level 3 Antepartum Stillbirth is defined by three criteria: first, delivery of an infant with no signs of life at birth, including the following: no spontaneous movements, no umbilical cord pulse, no heartbeat, no crying, no spontaneous respirations or chest movement, and full body cyanosis; second, one or more of the following three requirements must be met: a) Maternal report of the absence of fetal movement for 24 hours or more prior to delivery; b) Report of auscultation for fetal heart tones using electronic devices (e.g. handheld Doppler or fetal heart rate monitor) or non-electronic devices (e.g. stethoscope, fetoscope or Pinard horn) that documents the absence of a fetal heartbeat; c) Non-attended delivery followed by a post-delivery physical examination of the fetus that is performed by a health care professional who meets the standard of care in the immediate health care setting, and that is consistent with antepartum death; d) a verbal history provided by a trained health care provider, non-medical witness, or the mother of the fetus documenting that the fetus was born with no signs of life, was unresponsive to resuscitation efforts immediately after delivery, and had physical features consistent with antepartum death; third, gestational age within the pre-defined range for selected stillbirth definition as assessed by maternal and/or fetal parameters.	C126856	GAIA Stillbirth Level of Diagnostic Certainty Terminology
C127955	GAIA Level 3 Assessment of Insufficient Cervix	GAIA Level 3 Assessment of Insufficient Cervix is defined by three criteria: first, the following three requirements must be met: a) Presentation between 16 and 23 6/7 weeks gestation; b) Advanced cervical dilation greater than two centimeters, resulting in either treatment with a cerclage (cervical stitch) or preterm delivery; c) less than or equal to four contractions per hour as documented by a tocodynometer, meaning the patient is not in preterm labor; second, patient reported fetal delivery without painful contractions; third, the patient's history excludes other causes of mid-second trimester delivery.	Level 3 Assessment of Insufficient Cervix		Level 3 Assessment of Insufficient Cervix is defined by three criteria: first, the following three requirements must be met: a) Presentation between 16 and 23 6/7 weeks gestation; b) Advanced cervical dilation greater than two centimeters, resulting in either treatment with a cerclage (cervical stitch) or preterm delivery; c) less than or equal to four contractions per hour as documented by a tocodynometer, meaning the patient is not in preterm labor; second, patient reported fetal delivery without painful contractions; third, the patient's history excludes other causes of mid-second trimester delivery.	C126861	GAIA Pathways to Preterm Birth Level of Diagnostic Certainty Terminology
C127946	GAIA Level 3 Assessment of Premature Preterm Rupture of Membranes	GAIA Level 3 Assessment of Premature Preterm Rupture of Membranes is defined by three criteria: first, presentation between 24 0/7 and 36 6/7 weeks gestation with a clinical history of rupture of membranes, the fluid from which may be any color, including clear, blood-tinged, meconium-tinged (fetal stool), or purulent-tinged (yellowish, suggesting infection); second, the patient is determined to not be in preterm labor (having less than or equal to 4 contractions per hour documented clinically or on tocodynometer, with less than 2cm cervical dilation); third, visible leakage of presumed amniotic fluid, which may be on vaginal speculum examination (pooling in the vagina), on inspection of the perineum (wet perineum due to leakage of fluid from the vagina), or fluid soaked cloth/clothes/sanitary pad.	Level 3 Assessment of Premature Preterm Rupture of Membranes		Level 3 Assessment of Premature Preterm Rupture of Membranes is defined by three criteria: first, presentation between 24 0/7 and 36 6/7 weeks gestation with a clinical history of rupture of membranes, the fluid from which may be any colour, including clear, blood-tinged, meconium-tinged (fetal stool), or purulent-tinged (yellowish, suggesting infection); second, the patient is determined to not be in preterm labor (having less than or equal to 4 contractions per hour documented clinically or on tocodynometer, with less than 2cm cervical dilation); third, visible leakage of presumed amniotic fluid, which may be on vaginal speculum examination (pooling in the vagina), on inspection of the perineum (wet perineum due to leakage of fluid from the vagina), or fluid soaked cloth/clothes/sanitary pad.	C126861	GAIA Pathways to Preterm Birth Level of Diagnostic Certainty Terminology
C127949	GAIA Level 3 Assessment of Preterm Labor	GAIA Level 3 Assessment of Preterm Labor is defined by three criteria: first, confirmed delivery of a fetus between 24 0/7 and 36 6/7 weeks gestation; second, greater than four uterine contractions per hour as determined by clinical assessment; third, documented changes in cervical dilation or effacement during a two hour period.	Level 3 Assessment of Preterm Labor		Level 3 Assessment of Preterm Labor is defined by three criteria: first, confirmed delivery of a fetus between 24 0/7 and 36 6/7 weeks gestation; second, greater than four uterine contractions per hour as determined by clinical assessment; third, documented changes in cervical dilation or effacement during a two hour period.	C126861	GAIA Pathways to Preterm Birth Level of Diagnostic Certainty Terminology
C127952	GAIA Level 3 Assessment of Provider Initiated Preterm Delivery	GAIA Level 3 Assessment of Provider-Initiated Preterm Delivery is defined by three criteria: first, the patient is determined to be between 24 0/7 and 36 6/7 weeks gestation; second, from recall, the patient reports that there were no signs or symptoms of spontaneous onset of preterm labor; third, from recall, the patient reports that the healthcare provider indicated the need to induce labor or to perform a cesarean delivery between, resulting in preterm delivery.	Level 3 Assessment of Provider-Initiated Preterm Delivery		Level 3 Assessment of Provider-Initiated Preterm Delivery is defined by three criteria: first, the patient is determined to be between 24 0/7 and 36 6/7 weeks gestation; second, from recall, the patient reports that there were no signs or symptoms of spontaneous onset of preterm labor; third, from recall, the patient reports that the healthcare provider indicated the need to induce labor or to perform a cesarean delivery between, resulting in preterm delivery.	C126861	GAIA Pathways to Preterm Birth Level of Diagnostic Certainty Terminology
C128712	GAIA Level 3 Ectopic Pregnancy	GAIA Level 3 Ectopic Pregnancy is defined by four criteria: first, it does not qualify as either a Level 1 or a Level 2 Ectopic Pregnancy; second, gestational age is within the pre-defined range for the selected ectopic pregnancy definition as assessed by maternal and/or fetal parameters (Level 2-3) (Brighton Preterm Birth Gestational Age algorithm); third, a positive urine pregnancy test; fourth, no products of conception are found on endometrial curettage after a dilation and curettage procedure.	Level 3 Ectopic Pregnancy		Level 3 Ectopic Pregnancy is defined by four criteria: first, it does not qualify as either a Level 1 or a Level 2 Ectopic Pregnancy; second, gestational age is within the pre-defined range for the selected ectopic pregnancy definition as assessed by maternal and/or fetal parameters (Level 2-3) (Brighton Preterm Birth Gestational Age algorithm); third, a positive urine pregnancy test; fourth, no products of conception are found on endometrial curettage after a dilation and curettage procedure.	C128705	GAIA Spontaneous Abortion and Ectopic Pregnancy Level of Diagnostic Certainty Terminology
C128778	GAIA Level 3 First Trimester Spontaneous Abortion	GAIA Level 3 First Trimester Spontaneous Abortion is defined by three criteria: first, it does not qualify as either a Level 1 or Level 2 First Trimester Spontaneous Abortion; second, gestational age is within the pre-defined range for the selected abortion definition as assessed by maternal and/or fetal parameters (Level 3) (using Brighton Preterm Birth Gestational Age algorithm); third, a positive urine or blood pregnancy test that becomes negative after 7 days.	Level 3 First Trimester Spontaneous Abortion		Level 3 First Trimester Spontaneous Abortion is defined by three criteria: first, it does not qualify as either a Level 1 or Level 2 First Trimester Spontaneous Abortion; second, gestational age is within the pre-defined range for the selected abortion definition as assessed by maternal and/or fetal parameters (Level 3) (using Brighton Preterm Birth Gestational Age algorithm); third, a positive urine or blood pregnancy test that becomes negative after 7 days.	C128705	GAIA Spontaneous Abortion and Ectopic Pregnancy Level of Diagnostic Certainty Terminology
C128755	GAIA Level 3 Gestational Diabetes Mellitus	GAIA Level 3 Gestational Diabetes Mellitus is defined by three criteria: first, absence of pre-gestational diabetes [pre-gestational diabetes is defined as a) previous diagnosis of diabetes while not pregnant OR b) first trimester hemoglobin A1c level of greater than or equal to 6.5% (47.5 mmol/mol) OR c) first trimester fasting blood glucose greater than or equal to 126 mg/dL (7 mmol/L)]; second, gestational age with at least level 3 certainty, using the GAIA definition for gestational age; third, the diagnosis of gestational diabetes as determined by fasting plasma glucose of 5.1-6.9 mmol/L (92-125 mg/dL) using either venous or capillary blood samples.	Level 3 Gestational Diabetes Mellitus		Level 3 Gestational Diabetes Mellitus is defined by three criteria: first, absence of pre-gestational diabetes [pre-gestational diabetes is defined as a) previous diagnosis of diabetes while not pregnant OR b) first trimester hemoglobin A1c level of greater than or equal to 6.5% (47.5 mmol/mol) OR c) first trimester fasting blood glucose greater than or equal to 126 mg/dL (7 mmol/L)]; second, gestational age with at least level 3 certainty, using the GAIA definition for gestational age; third, the diagnosis of gestational diabetes as determined by fasting plasma glucose of 5.1-6.9 mmol/L (92-125 mg/dL) using either venous or capillary blood samples.	C128709	GAIA Gestational Diabetes Mellitus Level of Diagnostic Certainty Terminology
C128024	GAIA Level 3 Intrapartum Stillbirth	GAIA Level 3 Intrapartum Stillbirth is defined by four criteria: first, delivery of an infant who is reported to have no of signs of life at birth, including the following: no spontaneous movements, no umbilical cord pulse, no heartbeat, no crying, no spontaneous respirations or chest movement, and full body cyanosis; second, evidence of a live fetus prior to the onset of labor (maternal report of fetal movement prior to the onset of labor OR auscultation of fetal heart tones). NOTE: in the absence of evidence of a live fetus prior to the onset of labor, the fetal death should be reported as a stillbirth or an antepartum stillbirth; third, a non-attended delivery followed by a post-delivery physical examination that is performed by a health care professional who meets the standard of care in the immediate health care setting, and that is consistent with intrapartum death, or a verbal history that is provided by a trained health care provider, a non-medical witness, or the mother of the fetus that documents a fetus born with no signs of life and who was unresponsive to resuscitation efforts immediately after birth; fourth, gestational age within the pre-defined range for selected stillbirth definition as assessed by maternal and/or fetal parameters (level 2-3 in GA assessment algorithm).	Level 3 Intrapartum Stillbirth		Level 3 Intrapartum Stillbirth is defined by four criteria: first, delivery of an infant who is reported to have no of signs of life at birth, including the following: no spontaneous movements, no umbilical cord pulse, no heartbeat, no crying, no spontaneous respirations or chest movement, and full body cyanosis; second, evidence of a live fetus prior to the onset of labor (maternal report of fetal movement prior to the onset of labor OR auscultation of fetal heart tones). NOTE: in the absence of evidence of a live fetus prior to the onset of labor, the fetal death should be reported as a stillbirth or an antepartum stillbirth; third, a non-attended delivery followed by a post-delivery physical examination that is performed by a health care professional who meets the standard of care in the immediate health care setting, and that is consistent with intrapartum death, or a verbal history that is provided by a trained health care provider, a non-medical witness, or the mother of the fetus that documents a fetus born with no signs of life and who was unresponsive to resuscitation efforts immediately after birth; fourth, gestational age within the pre-defined range for selected stillbirth definition as assessed by maternal and/or fetal parameters (level 2-3 in GA assessment algorithm).	C126856	GAIA Stillbirth Level of Diagnostic Certainty Terminology
C128727	GAIA Level 3 Low Birth Weight	GAIA Level 3 Low Birth Weight is defined by three criteria: first, a newborn infant must be weighed within the  first 48 hours of life; second, weight is measured using a dial/ spring/ color-coded scale; third, weight is assessed as less than 2500 grams.	Level 3 Low Birth Weight		Level 3 Low Birth Weight is defined by three criteria: first, a newborn infant must be weighed within the  first 48 hours of life; second, weight is measured using a dial/ spring/ color-coded scale; third, weight is assessed as less than 2500 grams.	C128701	GAIA Low Birth Weight Level of Diagnostic Certainty Terminology
C127959	GAIA Level 3 Major External Structural Defect	GAIA Level 3 Major External Structural Defect is defined by four criteria: first, the defects are of a prenatal origin; second, at least one of the following requirements must be met: a) Alterations in the external anatomy that are present and visible at the time of live birth, and that persist beyond the immediate peripartum period unless surgically repaired OR b) Alterations in the external anatomy that are present and visible in a stillbirth or in the products of conception of a spontaneous or therapeutic abortion; third, the defect(s) affect (or have the propensity to affect) the health, survival, or physical or cognitive functioning of the individual; fourth, at least one of the following requirements must be met: a) Documented confirmation of a diagnosis made by a trained maternal or child health care provider with at least minimal experience diagnosing congenital anomalies; OR b) For live births, the diagnosis is confirmed using individual (ICD-9/ICD-10) codes or as part of an ICD-9/ICD-10 code based algorithm, for which the outcome (individual code or algorithm) has been validated.	Level 3 Major External Structural Defect		Level 3 Major External Structural Defect is defined by four criteria: first, the defects are of a prenatal origin; second, at least one of the following requirements must be met: a) Alterations in the external anatomy that are present and visible at the time of live birth, and that persist beyond the immediate peripartum period unless surgically repaired OR b) Alterations in the external anatomy that are present and visible in a stillbirth or in the products of conception of a spontaneous or therapeutic abortion; third, the defect(s) affect (or have the propensity to affect) the health, survival, or physical or cognitive functioning of the individual; fourth, at least one of the following requirements must be met: a) Documented confirmation of a diagnosis made by a trained maternal or child health care provider with at least minimal experience diagnosing congenital anomalies; OR b) For live births, the diagnosis is confirmed using individual (ICD-9/ICD-10) codes or as part of an ICD-9/ICD-10 code based algorithm, for which the outcome (individual code or algorithm) has been validated.	C126852	GAIA Major Congenital Anomalies Level of Diagnostic Certainty Terminology
C127967	GAIA Level 3 Major Functional Defect	GAIA Level 3 Major Functional Defect is defined by two criteria: first, at least one of the following requirements must be met: a) For live births, there must be alterations in the functioning of one or more organs or body parts that are not due to a structural defect, that are present at live birth (or propensity to develop alteration present at live birth), and that persist beyond the immediate peripartum period, unless treated through gene therapy or stem cell transplantation; OR b) For stillbirths or spontaneous or therapeutic abortions, there must be alterations in the functioning of one or more organs or body parts that are not due to a structural defect; second, at least one of the following requirements must be met: a) Documented confirmation of a diagnosis made by a clinician who has some experience diagnosing functional defects; OR b) Confirmation of a diagnosis using either individual (ICD-9/ICD-10) codes or as part of an ICD-9/ICD-10 code based algorithm, for which the outcome (individual code or algorithm) has been validated.	Level 3 Major Functional Defect		Level 3 Major Functional Defect is defined by two criteria: first, at least one of the following requirements must be met: a) For live births, there must be alterations in the functioning of one or more organs or body parts that are not due to a structural defect, that are present at live birth (or propensity to develop alteration present at live birth), and that persist beyond the immediate peripartum period, unless treated through gene therapy or stem cell transplantation; OR b) For stillbirths or spontaneous or therapeutic abortions, there must be alterations in the functioning of one or more organs or body parts that are not due to a structural defect; second, at least one of the following requirements must be met: a) Documented confirmation of a diagnosis made by a clinician who has some experience diagnosing functional defects; OR b) Confirmation of a diagnosis using either individual (ICD-9/ICD-10) codes or as part of an ICD-9/ICD-10 code based algorithm, for which the outcome (individual code or algorithm) has been validated.	C126852	GAIA Major Congenital Anomalies Level of Diagnostic Certainty Terminology
C127963	GAIA Level 3 Major Internal Structural Defect	GAIA Level 3 Major Internal Structural Defect is defined by three criteria: first, the defects are prenatal in origin; second, the defect(s) affect (or have the propensity to affect) the health, survival, or physical or cognitive functioning of the individual; third, for a live birth, alterations in the internal anatomy must be present at the time of live birth, must persist beyond the immediate peripartum period unless surgically repaired, and must either a) Require documented confirmation of a diagnosis made by a clinician with some experience diagnosing congenital anomalies; OR b) Confirmation of a diagnosis using either individual (ICD-9/ICD-10) codes or as part of an ICD-9/ICD-10 code based algorithm, for which the outcome (individual code or algorithm) has been validated.	Level 3 Major Internal Structural Defect		Level 3 Major Internal Structural Defect is defined by three criteria: first, the defects are prenatal in origin; second, the defect(s) affect (or have the propensity to affect) the health, survival, or physical or cognitive functioning of the individual; third, for a live birth, alterations in the internal anatomy must be present at the time of live birth, must persist beyond the immediate peripartum period unless surgically repaired, and must either a) Require documented confirmation of a diagnosis made by a clinician with some experience diagnosing congenital anomalies; OR b) Confirmation of a diagnosis using either individual (ICD-9/ICD-10) codes or as part of an ICD-9/ICD-10 code based algorithm, for which the outcome (individual code or algorithm) has been validated.	C126852	GAIA Major Congenital Anomalies Level of Diagnostic Certainty Terminology
C127999	GAIA Level 3 Maternal Death	GAIA Level 3 Maternal Death is defined by three criteria: first, the absence of level 1 or level 2 criteria for establishing diagnosis of pregnancy, and both the uncertainty of the individual's last menstrual period date and no documented clinical examination; second, death of the mother temporal to pregnancy, childbirth, or the postpartum period when exact timing of death is unknown; third, documentation of the maternal cause of death wherein one of the following requirements must be met: a) Direct: abortive outcome, hypertensive disorder, obstetric hemorrhage, pregnancy related infection, other obstetric complications, unanticipated complications; b) Indirect: non-obstetric complications; c) Death during pregnancy, childbirth, and the puerperium: other or coincidental; d) Unspecified: unknown or undetermined.	Level 3 Maternal Death		Level 3 Maternal Death is defined by three criteria: first, the absence of level 1 or level 2 criteria for establishing diagnosis of pregnancy, and both the uncertainty of the individual's last menstrual period date and no documented clinical examination; second, death of the mother temporal to pregnancy, childbirth, or the postpartum period when exact timing of death is unknown; third, documentation of the maternal cause of death wherein one of the following requirements must be met: a) Direct: abortive outcome, hypertensive disorder, obstetric hemorrhage, pregnancy related infection, other obstetric complications, unanticipated complications; b) Indirect: non-obstetric complications; c) Death during pregnancy, childbirth, and the puerperium: other or coincidental; d) Unspecified: unknown or undetermined.	C126858	GAIA Maternal Death Level of Diagnostic Certainty Terminology
C127983	GAIA Level 3 Maternal Immunization	GAIA Level 3 Maternal immunization is defined by two criteria: first, the woman/medical attendant reports the pregnancy; second, the woman reports receipt of vaccination during pregnancy, but no formal recording of the immunization is available.	Level 3 Maternal Immunisation		Level 3 Maternal immunization is defined by two criteria: first, the woman/medical attendant reports the pregnancy; second, the woman reports receipt of vaccination during pregnancy, but no formal recording of the immunization is available.	C126853	GAIA Neonatal Death Level of Diagnostic Certainty Terminology
C127971	GAIA Level 3 Neonatal Death in a Non-viable Live Birth	GAIA Level 3 Neonatal Death in a Non-viable Live Birth is defined by three criteria: first, the infant must be live born; second, the gestational age must be less than 5 months according to parent/family member/delivery attendant (a GA level of certainty of either level two or three); third, the death of the infant within the first 28 days of life must be documented.	Level 3 Neonatal Death in a Non-viable Live Birth		Level 3 Neonatal Death in a Non-viable Live Birth is defined by three criteria: first, the infant must be live born; second, the gestational age must be less than 5 months according to parent/family member/delivery attendant (a GA level of certainty of either level two or three); third, the death of the infant within the first 28 days of life must be documented.	C126853	GAIA Neonatal Death Level of Diagnostic Certainty Terminology
C127977	GAIA Level 3 Neonatal Death in a Preterm Live Birth	GAIA Level 3 Neonatal Death in a Preterm Live Birth is defined by three criteria: first, the infant must be live born; second, the gestational age must be greater than or equal to 7 months but less than 9 months according to parent/family member/delivery attendant (a GA level of certainty of either level two or three); third, the death of the infant within the first 28 days of life must be documented.	Level 3 Neonatal Death in a Preterm Live Birth		Level 3 Neonatal Death in a Preterm Live Birth is defined by three criteria: first, the infant must be live born; second, the gestational age must be greater than or equal to 7 months but less than 9 months according to parent/family member/delivery attendant (a GA level of certainty of either level two or three); third, the death of the infant within the first 28 days of life must be documented.	C126853	GAIA Neonatal Death Level of Diagnostic Certainty Terminology
C127980	GAIA Level 3 Neonatal Death in a Term Live Birth	GAIA Level 3 Neonatal Death in a Term Live Birth is defined by three criteria: first, the infant must be live born; second, the gestational age must be greater than or equal to 9 months according to parent/ family member/delivery attendant (a GA level of certainty of either level two or three); third, the death of the infant within the first 28 days of life must be documented.	Level 3 Neonatal Death in a Term Live Birth		Level 3 Neonatal Death in a Term Live Birth is defined by three criteria: first, the infant must be live born; second, the gestational age must be greater than or equal to 9 months according to parent/ family member/delivery attendant (a GA level of certainty of either level two or three); third, the death of the infant within the first 28 days of life must be documented.	C126853	GAIA Neonatal Death Level of Diagnostic Certainty Terminology
C127974	GAIA Level 3 Neonatal Death in an Extremely Preterm Live Birth	GAIA Level 3 Neonatal Death in an Extremely Preterm Live Birth is defined by three criteria: first, the infant must be live born; second, the gestational age must be greater than or equal to 5 months but less than 7 months according to parent/family member/delivery attendant (a GA level of certainty of either level two or three); third, the death of the infant within the first 28 days of life must be documented.	Level 3 Neonatal Death in an Extremely Preterm Live Birth		Level 3 Neonatal Death in an Extremely Preterm Live Birth is defined by three criteria: first, the infant must be live born; second, the gestational age must be greater than or equal to 5 months but less than 7 months according to parent/family member/delivery attendant (a GA level of certainty of either level two or three); third, the death of the infant within the first 28 days of life must be documented.	C126853	GAIA Neonatal Death Level of Diagnostic Certainty Terminology
C128731	GAIA Level 3 Neonatal Encephalopathy	GAIA Level 3 Neonatal Encephalopathy is defined by three criteria: first, a newborn infant (1-28 days of life) born at or beyond 35 weeks of gestation; second, an abnormal level of alertness or seizures; third, none of the following: a) difficulty with initiating or maintaining respiration; b) depression of muscle tone.	Level 3 Neonatal Encephalopathy		Level 3 Neonatal Encephalopathy is defined by three criteria: first, a newborn infant (1-28 days of life) born at or beyond 35 weeks of gestation; second, an abnormal level of alertness or seizures; third, none of the following: a) difficulty with initiating or maintaining respiration; b) depression of muscle tone.	C128699	GAIA Neonatal Encephalopathy Level of Diagnostic Certainty Terminology
C127986	GAIA Level 3 Neonatal Invasive Bloodstream Infection	GAIA Level 3 Neonatal Invasive Bloodstream Infection is defined by two criteria: first, the criteria does not meet the requirements for level 1 or 2 diagnostic certainty; second, two or more of the following requirements must be met: a) Temperature greater than or equal to 37.5 degrees C or less than 35.5 degrees C; b) Tachypnea or severe chest indrawing or grunting or cyanosis; c) Change in level of activity; d) History of feeding difficulty; e) History of convulsions.	Level 3 Neonatal Blood Stream Infection		Level 3 Neonatal Invasive Blood Stream Infection is defined by two criteria: first, the criteria does not meet the requirements for level 1 or 2 diagnostic certainty; second, two or more of the following requirements must be met: a) Temperature greater than or equal to 37.5 degrees C or less than 35.5 degrees C; b) Tachypnea or severe chest indrawing or grunting or cyanosis; c) Change in level of activity; d) History of feeding difficulty; e) History of convulsions.	C126854	GAIA Neonatal Infections Level of Diagnostic Certainty Terminology
C127993	GAIA Level 3 Neonatal Respiratory Tract Infection	GAIA Level 3 Neonatal Respiratory Tract Infection is defined by the presence of two or more of the following criteria: a) Difficulty in breathing/tachypnea; b) Severe chest indrawing; c) Nasal flaring; d) Grunting; e) Wheeze; f) Stridor.	Level 3 Neonatal Respiratory Tract Infection		Level 3 Neonatal Respiratory Tract Infection is defined by the presence of two or more of the following criteria: a) Difficulty in breathing/tachypnea; b) Severe chest indrawing; c) Nasal flaring; d) Grunting; e) Wheeze; f) Stridor.	C126854	GAIA Neonatal Infections Level of Diagnostic Certainty Terminology
C127996	GAIA Level 3 Non-reassuring Fetal Status	GAIA Level 3 Non-reassuring Fetal Status is defined by the presence of the following criteria: A fetal heart pattern that is detected via intermittent auscultation, and that is suggestive of fetal hypoxia, including the following requirements that must be met: a) Baseline fetal heart rate less than 110 bpm or greater than 160 bpm; b) Presence of repetitive or prolonged (greater than 3 minutes) decelerations; c) More than five contractions in a ten minute period.	Level 3 Non-reassuring Fetal Status		Level 3 Non-reassuring Fetal Status is defined by the presence of the following criteria: A fetal heart pattern that is detected via intermittent auscultation, and that is suggestive of fetal hypoxia, including the following requirements that must be met: a) Baseline fetal heart rate less than 110 bpm or greater than 160 bpm; b) Presence of repetitive or prolonged (greater than 3 minutes) decelerations; c) More than five contractions in a ten minute period.	C126857	GAIA Non-Reassuring Fetal Status Level of Diagnostic Certainty Terminology
C128002	GAIA Level 3 Postpartum Hemorrhage	GAIA Level 3 Postpartum Hemorrhage is defined by the presence of genital bleeding after delivery that is estimated at 1000ml or more.	Level 3 Postpartum Haemorrhage		Level 3 Postpartum Hemorrhage is defined by the presence of genital bleeding after delivery that is estimated at 1000ml or more.	C126859	GAIA Postpartum Hemorrhage Level of Diagnostic Certainty Terminology
C128016	GAIA Level 3a Assessment of Gestational Age	GAIA Level 3a Assessment of Gestational Age is defined by the presence at least one of the following criteria: a) Certain last menstrual period (LMP) date with third trimester scan (28 0/7 weeks or more); OR b) Certain LMP date with confirmatory second trimester fundal height (FH); OR c) Certain LMP date with birth weight; OR d) Uncertain LMP date with first trimester physical examination.	Level 3a Assessment of Prematurity and Gestational Age		Level 3a Assessment of Gestational Age is defined by the presence at least one of the following criteria: a) Certain last menstrual period (LMP) date with third trimester scan (28 0/7 weeks or more); OR b) Certain LMP date with confirmatory second trimester fundal height (FH); OR c) Certain LMP date with birth weight; OR d) Uncertain LMP date with first trimester physical examination.	C126855	GAIA Preterm Birth Level of Diagnostic Certainty Terminology
C128773	GAIA Level 3a Failure to Thrive	GAIA Level 3a Failure to Thrive is defined by four criteria: first, infants with an undocumented birth date, where age is determined based on mother's recall to the nearest month; second, weight obtained using either beam balance or spring balance scale; third, a minimum of two weights measured at least four weeks apart; fourth, weight for age deceleration must pass through at least two centile spaces on a growth chart.	Level 3a Failure to Thrive		Level 3a Failure to Thrive is defined by four criteria: first, infants with an undocumented birth date, where age is determined based on mother's recall to the nearest month; second, weight obtained using either beam balance or spring balance scale; third, a minimum of two weights measured at least four weeks apart; fourth, weight for age deceleration must pass through at least two centile spaces on a growth chart.	C128704	GAIA Failure to Thrive Level of Diagnostic Certainty Terminology
C127989	GAIA Level 3a Neonatal Infectious Meningitis	GAIA Level 3a Neonatal Infectious Meningitis is defined by four criteria: first, CSF pleocytosis; second, NO recognized pathogen is identified, using a validated method, from a normally sterile site; third, temperature greater than or equal to 37.5 degrees C or less than 35.5 degrees C; fourth, three or more of the following requirements must be met: a) History of convulsions; b) Lethargy or irritability; c) Coma; d) Apnea; e) Bulging fontanel; f) Neck stiffness.	Level 3a Neonatal Bacterial/Fungal/Viral Meningitis		Level 3a Neonatal Infectious Meningitis is defined by four criteria: first, CSF pleocytosis; second, NO recognized pathogen is identified, using a validated method, from a normally sterile site; third, temperature greater than or equal to 37.5 degrees C or less than 35.5 degrees C; fourth, three or more of the following requirements must be met: a) History of convulsions; b) Lethargy or irritability; c) Coma; d) Apnea; e) Bulging fontanel; f) Neck stiffness.	C126854	GAIA Neonatal Infections Level of Diagnostic Certainty Terminology
C129604	GAIA Level 3a Postnatally Diagnosed Congenital Microcephaly	GAIA Level 3a Postnatally Diagnosed Congenital Microcephaly is defined by three criteria: first, a live birth, stillbirth, or spontaneous or therapeutic abortion of at least 24 weeks GA based on LMP without confirmatory 1st or 2nd trimester ultrasound; second, a head circumference (HC) measurement either 2 standard deviations (SD) below the mean or less than the third percentile as assessed by GA and gender, using appropriate, standardized reference charts for the population (e.g. WHO growth reference charts if GA greater than or equal to 37 weeks and Intergrowth-21st reference charts for GA 24 to 36 weeks); third, the measurement is taken up to 6 weeks after birth or end of pregnancy, with no apparent post-natal insult resulting in microcephaly.	Level 3a Postnatally Diagnosed Congenital Microcephaly		Level 3a Postnatally Diagnosed Congenital Microcephaly is defined by three criteria: first, a live birth, stillbirth, or spontaneous or therapeutic abortion of at least 24 weeks GA based on LMP without confirmatory 1st or 2nd trimester ultrasound; second, a head circumference (HC) measurement either 2 standard deviations (SD) below the mean or less than the third percentile as assessed by GA and gender, using appropriate, standardized reference charts for the population (e.g. WHO growth reference charts if GA greater than or equal to 37 weeks and Intergrowth-21st reference charts for GA 24 to 36 weeks); third, the measurement is taken up to 6 weeks after birth or end of pregnancy, with no apparent post-natal insult resulting in microcephaly.	C128700	GAIA Congenital Microcephaly Level of Diagnostic Certainty Terminology
C129605	GAIA Level 3a Prenatally Diagnosed Congenital Microcephaly	GAIA Level 3A Prenatally Diagnosed Congenital Microcephaly is defined by three criteria: first, the fetus is at least 24 weeks gestational age (GA), with GA based on certain last menstrual period (LMP) date, with confirmatory first or second trimester ultrasound (US) scan, OR uncertain LMP with second trimester ultrasound, intrauterine insemination (IUI) OR embryo transfer date; second, a head circumference (HC) measurement either 2 standard deviations (SD) below the mean or less than the third percentile according to fetal US examination, using appropriate, standardized reference charts according to GA and gender for the population (e.g. WHO growth reference charts if GA greater than or equal to 37 weeks and Intergrowth-21st reference charts for GA 24 to 36 weeks); third, no confirmation of microcephaly with any additional US or by HC measurement at either birth or autopsy.	Level 3a Prenatally Diagnosed Congenital Microcephaly		Level 3A Prenatally Diagnosed Congenital Microcephaly is defined by three criteria: first, the fetus is at least 24 weeks gestational age (GA), with GA based on certain last menstrual period (LMP) date, with confirmatory first or second trimester ultrasound (US) scan, OR uncertain LMP with second trimester ultrasound, intrauterine insemination (IUI) OR embryo transfer date; second, a head circumference (HC) measurement either 2 standard deviations (SD) below the mean or less than the third percentile according to fetal US examination, using appropriate, standardized reference charts according to GA and gender for the population (e.g. WHO growth reference charts if GA greater than or equal to 37 weeks and Intergrowth-21st reference charts for GA 24 to 36 weeks); third, no confirmation of microcephaly with any additional US or by HC measurement at either birth or autopsy.	C128700	GAIA Congenital Microcephaly Level of Diagnostic Certainty Terminology
C128736	GAIA Level 3a Small for Gestational Age	GAIA Level 3a Small for Gestational Age is defined by three criteria: first, weight is below the 10th percentile for gestational age; second, the newborn is weighed within the first 48 hours of life on any scale with a less than or equal to 50 g resolution, calibrated and tared to zero; third, gestational age assessed by one of the following four methods: a) Certain LMP with third trimester ultrasound; b) Certain LMP with confirmatory 2nd trimester fundal height; c) Certain LMP with birthweight; or d) Uncertain LMP with first trimester physical exam.	Level 3a Small for Gestational Age		Level 3a Small for Gestational Age is defined by three criteria: first, weight is below the 10th percentile for gestational age; second, the newborn is weighed within the first 48 hours of life on any scale with a less than or equal to 50 g resolution, calibrated and tared to zero; third, gestational age assessed by one of the following four methods: a) Certain LMP with third trimester ultrasound; b) Certain LMP with confirmatory 2nd trimester fundal height; c) Certain LMP with birthweight; or d) Uncertain LMP with first trimester physical exam.	C128703	GAIA Small for Gestational Age Level of Diagnostic Certainty Terminology
C128017	GAIA Level 3b Assessment of Gestational Age	GAIA Level 3b Assessment of Gestational Age is defined by the presence of at least one of the following criteria: a) Uncertain last menstrual period (LMP) date with fundal height (FH); OR b) Uncertain LMP date with newborn physical assessment; OR c) Uncertain LMP date with birth weight.	Level 3b Assessment of Prematurity and Gestational Age		Level 3b Assessment of Gestational Age is defined by the presence of at least one of the following criteria: a) Uncertain last menstrual period (LMP) date with fundal height (FH); OR b) Uncertain LMP date with newborn physical assessment; OR c) Uncertain LMP date with birth weight.	C126855	GAIA Preterm Birth Level of Diagnostic Certainty Terminology
C128774	GAIA Level 3b Failure to Thrive	GAIA Level 3b Failure to Thrive is defined by three criteria: first, infants have no weight available; second, physical examination is consistent with failure to thrive, which is defined as having at least two findings, one of which must be a major finding: reduced subcutaneous fat stores, poor muscle mass, loose skin folds, prominent ribs, and thin limbs. Less specific findings include sparse hair, rashes, pallor, irritable temperament, and lethargy/fatigue; third, a mid-upper arm circumference (MUAC) measurement, which is indicative of severe wasting, that is less than or equal to 110 mm in infants up to six months of age, and that is less than or equal to 115 mm in infants six to twelve months of age.	Level 3b Failure to Thrive		Level 3b Failure to Thrive is defined by three criteria: first, infants have no weight available; second, physical examination is consistent with failure to thrive, which is defined as having at least two findings, one of which must be a major finding: reduced subcutaneous fat stores, poor muscle mass, loose skin folds, prominent ribs, and thin limbs. Less specific findings include sparse hair, rashes, pallor, irritable temperament, and lethargy/fatigue; third, a mid-upper arm circumference (MUAC) measurement, which is indicative of severe wasting, that is less than or equal to 110 mm in infants up to six months of age, and that is less than or equal to 115 mm in infants six to twelve months of age.	C128704	GAIA Failure to Thrive Level of Diagnostic Certainty Terminology
C127990	GAIA Level 3b Neonatal Infectious Meningitis	GAIA Level 3b Neonatal Infectious Meningitis is defined by three criteria: first, no lumbar puncture is done or no sample is available; second, temperature greater than or equal to 37.5 degrees C or less than 35.5 degrees C; third, four or more of the following requirements must be met: a) History of convulsions; b) Lethargy or irritability; c) Coma; d) Apnea; e) Bulging fontanel; f) Neck stiffness.	Level 3b Neonatal Meningitis		Level 3b Neonatal Infectious Meningitis is defined by three criteria: first, no lumbar puncture is done or no sample is available; second, temperature greater than or equal to 37.5 degrees C or less than 35.5 degrees C; third, four or more of the following requirements must be met: a) History of convulsions; b) Lethargy or irritability; c) Coma; d) Apnea; e) Bulging fontanel; f) Neck stiffness.	C126854	GAIA Neonatal Infections Level of Diagnostic Certainty Terminology
C128760	GAIA Level 3b Postnatally Diagnosed Congenital Microcephaly	GAIA Level 3b Postnatally Diagnosed Congenital Microcephaly is defined by two criteria: first, a live birth, stillbirth, or spontaneous or therapeutic abortion, and second, the case meets criteria for microcephaly using a validated algorithm: 1 inpatient diagnosis OR 2 outpatient diagnoses OR 1 outpatient diagnosis AND death in first year using the following diagnostic codes ICD-9-CM code 742.1 or ICD-10-CM code Q02.	Level 3b Postnatally Diagnosed Congenital Microcephaly		Level 3b Postnatally Diagnosed Congenital Microcephaly is defined by two criteria: first, a live birth, stillbirth, or spontaneous or therapeutic abortion, and second, the case meets criteria for microcephaly using a validated algorithm: 1 inpatient diagnosis OR 2 outpatient diagnoses OR 1 outpatient diagnosis AND death in first year using the following diagnostic codes ICD-9-CM code 742.1 or ICD-10-CM code Q02.	C128700	GAIA Congenital Microcephaly Level of Diagnostic Certainty Terminology
C128765	GAIA Level 3b Prenatally Diagnosed Congenital Microcephaly	GAIA Level 3B Prenatally Diagnosed Congenital Microcephaly is defined by three criteria: first, the fetus is at least 24 weeks gestational age (GA), with GA based on certain or uncertain last menstrual period (LMP) date, with fundal height and no confirmatory first or second trimester ultrasound (US) scan, OR uncertain LMP with second trimester ultrasound, intrauterine insemination (IUI) OR embryo transfer date; second, a head circumference (HC) measurement either 2 standard deviations (SD) below the mean or less than the third percentile according to fetal US examination, using appropriate, standardized reference charts according to GA and gender for the population (e.g. WHO growth reference charts if GA greater than or equal to 37 weeks and Intergrowth-21st reference charts for GA 24 to 36 weeks); third, no confirmation of microcephaly with any additional US or by HC measurement at either birth or autopsy.	Level 3b Prenatally Diagnosed Congenital Microcephaly		Level 3B Prenatally Diagnosed Congenital Microcephaly is defined by three criteria: first, the fetus is at least 24 weeks gestational age (GA), with GA based on certain or uncertain last menstrual period (LMP) date, with fundal height and no confirmatory first or second trimester ultrasound (US) scan, OR uncertain LMP with second trimester ultrasound, intrauterine insemination (IUI) OR embryo transfer date; second, a head circumference (HC) measurement either 2 standard deviations (SD) below the mean or less than the third percentile according to fetal US examination, using appropriate, standardized reference charts according to GA and gender for the population (e.g. WHO growth reference charts if GA greater than or equal to 37 weeks and Intergrowth-21st reference charts for GA 24 to 36 weeks); third, no confirmation of microcephaly with any additional US or by HC measurement at either birth or autopsy.	C128700	GAIA Congenital Microcephaly Level of Diagnostic Certainty Terminology
C128737	GAIA Level 3b Small for Gestational Age	GAIA Level 3b Small for Gestational Age is defined by three criteria: first, the weight is below the 10th percentile for gestational age; second, the infant is weighed within the first 48 hours of life, and the weight is assessed on any scale by measuring the difference between an adult holding the infant and the adult being weighed alone; third, gestational age is assessed by one of following three methods: a) Uncertain LMP with fundal height; b) Uncertain LMP with newborn physical assessment; or c) Uncertain LMP with birthweight.	Level 3b Small for Gestational Age		Level 3b Small for Gestational Age is defined by three criteria: first, the weight is below the 10th percentile for gestational age; second, the infant is weighed within the first 48 hours of life, and the weight is assessed on any scale by measuring the difference between an adult holding the infant and the adult being weighed alone; third, gestational age is assessed by one of following three methods: a) Uncertain LMP with fundal height; b) Uncertain LMP with newborn physical assessment; or c) Uncertain LMP with birthweight.	C128703	GAIA Small for Gestational Age Level of Diagnostic Certainty Terminology
C128021	GAIA Level 4 Antepartum Stillbirth	GAIA Level 4 Antepartum Stillbirth is defined by two criteria: first, a report of a stillbirth, but the fetus is unavailable for physical examination after birth so no objective assessment can be made; second, maternal information is insufficient to assess gestational age.	Level 4 Antepartum Stillbirth		Level 4 Antepartum Stillbirth is defined by two criteria: first, a report of a stillbirth, but the fetus is unavailable for physical examination after birth so no objective assessment can be made; second, maternal information is insufficient to assess gestational age.	C126856	GAIA Stillbirth Level of Diagnostic Certainty Terminology
C128713	GAIA Level 4 Ectopic Pregnancy	GAIA Level 4 Ectopic Pregnancy is defined by two criteria: first, it does not qualify as a Level 1, a Level 2, or a Level 3 Ectopic Pregnancy; second, a maternal self-report or documentation in the medical record of a pregnancy loss without sufficient ultrasound or laboratory evidence to confirm.	Level 4 Ectopic Pregnancy		Level 4 Ectopic Pregnancy is defined by two criteria: first, it does not qualify as a Level 1, a Level 2, or a Level 3 Ectopic Pregnancy; second, a maternal self-report or documentation in the medical record of a pregnancy loss without sufficient ultrasound or laboratory evidence to confirm.	C128705	GAIA Spontaneous Abortion and Ectopic Pregnancy Level of Diagnostic Certainty Terminology
C128779	GAIA Level 4 First Trimester Spontaneous Abortion	GAIA Level 4 First Trimester Spontaneous Abortion is defined by two criteria: first, it does not qualify as a Level 1, a Level 2, or a Level 3 First Trimester Spontaneous Abortion; second, a maternal self-report or documentation in the medical record of a pregnancy loss without sufficient ultrasound or laboratory evidence to confirm.	Level 4 First Trimester Spontaneous Abortion		Level 4 First Trimester Spontaneous Abortion is defined by two criteria: first, it does not qualify as a Level 1, a Level 2, or a Level 3 First Trimester Spontaneous Abortion; second, a maternal self-report or documentation in the medical record of a pregnancy loss without sufficient ultrasound or laboratory evidence to confirm.	C128705	GAIA Spontaneous Abortion and Ectopic Pregnancy Level of Diagnostic Certainty Terminology
C128025	GAIA Level 4 Intrapartum Stillbirth	GAIA Level 4 Intrapartum Stillbirth is defined by two criteria: first, a report of stillbirth, but the fetus is unavailable for physical examination after birth so no objective assessment can be made; second, maternal information is insufficient to assess gestational age.	Level 4 Intrapartum Stillbirth		Level 4 Intrapartum Stillbirth is defined by two criteria: first, a report of stillbirth, but the fetus is unavailable for physical examination after birth so no objective assessment can be made; second, maternal information is insufficient to assess gestational age.	C126856	GAIA Stillbirth Level of Diagnostic Certainty Terminology
C128728	GAIA Level 4 Low Birth Weight	GAIA Level 4 Low Birth Weight is defined by either one of the following two criteria: first, the newborn's weight is assessed between 1 and 2 days of age (first 48 hrs of life); AND second, a proxy measure of birth weight is used, AND the weight category is assessed as less than 2500 grams.	Level 4 Low Birth Weight		Level 4 Low Birth Weight is defined by either one of the following two criteria: first, the newborn's weight is assessed between 1 and 2 days of age (first 48 hrs of life); AND second, a proxy measure of birth weight is used, AND the weight category is assessed as less than 2500 grams.	C128701	GAIA Low Birth Weight Level of Diagnostic Certainty Terminology
C127960	GAIA Level 4 Major External Structural Defect	GAIA Level 4 Major External Structural Defect is defined by four criteria: first, the defects are of a prenatal origin; second, at least one of the following requirements must be met: a) Alterations in the external anatomy that are present and visible at the time of live birth, and that persist beyond the immediate peripartum period unless surgically repaired OR b) Alterations in the external anatomy that are present and visible in a stillbirth or in the products of conception of a spontaneous or therapeutic abortion; third, the defect(s) affect (or have the propensity to affect) the health, survival, or physical or cognitive functioning of the individual; fourth, at least one of the following requirements must be met: a) Confirmation by medical record review; OR b) Confirmed in claims data (ICD-9/ICD-10 diagnoses).	Level 4 Major External Structural Defect		Level 4 Major External Structural Defect is defined by four criteria: first, the defects are of a prenatal origin; second, at least one of the following requirements must be met: a) Alterations in the external anatomy that are present and visible at the time of live birth, and that persist beyond the immediate peripartum period unless surgically repaired OR b) Alterations in the external anatomy that are present and visible in a stillbirth or in the products of conception of a spontaneous or therapeutic abortion; third, the defect(s) affect (or have the propensity to affect) the health, survival, or physical or cognitive functioning of the individual; fourth, at least one of the following requirements must be met: a) Confirmation by medical record review; OR b) Confirmed in claims data (ICD-9/ICD-10 diagnoses).	C126852	GAIA Major Congenital Anomalies Level of Diagnostic Certainty Terminology
C127968	GAIA Level 4 Major Functional Defect	GAIA Level 4 Major Functional Defect is defined by two criteria: first, at least one of the following requirements must be met: a) For live births, there must be alterations in the functioning of one or more organs or body parts that are not due to a structural defect, that are present at the time of live birth (or propensity to develop alteration present at live birth), and that persist beyond the immediate peripartum period, unless treated through gene therapy or stem cell transplantation; OR b) For stillbirths or spontaneous or therapeutic abortions, there must be alterations in the function of one or more organs or body parts that are not due to a structural defect; second, at least one of the following requirements must be met: a) Documented confirmation in the medical record that the anomaly was present at the time of live birth or at the time of fetal demise, and that the anomaly was diagnosed by a trained maternal or child health care provider who is not a qualified geneticist, neonatologist, pathologist, subspecialist, pediatrician, obstetrician, or family medicine practitioner; OR b) Confirmation by claims data (ICD-9/ICD-10 diagnoses).	Level 4 Major Functional Defect		Level 4 Major Functional Defect is defined by two criteria: first, at least one of the following requirements must be met: a) For live births, there must be alterations in the functioning of one or more organs or body parts that are not due to a structural defect, that are present at the time of live birth (or propensity to develop alteration present at live birth), and that persist beyond the immediate peripartum period, unless treated through gene therapy or stem cell transplantation; OR b) For stillbirths or spontaneous or therapeutic abortions, there must be alterations in the function of one or more organs or body parts that are not due to a structural defect; second, at least one of the following requirements must be met: a) Documented confirmation in the medical record that the anomaly was present at the time of live birth or at the time of fetal demise, and that the anomaly was diagnosed by a trained maternal or child health care provider who is not a qualified geneticist, neonatologist, pathologist, subspecialist, paediatrician, obstetrician, or family medicine practitioner; OR b) Confirmation by claims data (ICD-9/ICD-10 diagnoses).	C126852	GAIA Major Congenital Anomalies Level of Diagnostic Certainty Terminology
C127964	GAIA Level 4 Major Internal Structural Defect	GAIA Level 4 Major Internal Structural Defect is defined by three criteria: first, the defects are prenatal in origin; second, the defect(s) affect (or have the propensity to affect) the health, survival, or physical or cognitive functioning of the individual; third, at least one of the following requirements must be met: a) Alterations in the internal anatomy that are present at the time of live birth, and that persist beyond the immediate peripartum period unless surgically repaired; OR b) Alterations in the internal anatomy that are present at the time of the stillbirth or of the spontaneous or therapeutic abortion; fourth, at least one of the following requirements must be met: a) Documented confirmation in the medical record that the anomaly was present at the time of live birth or at the time of fetal demise, and that the anomaly was diagnosed by a trained maternal or a child health care provider who has minimal experience diagnosing congenital anomalies; OR b) Confirmed by claims data (ICD-9/ICD-10 diagnoses).	Level 4 Major Internal Structural Defect		Level 4 Major Internal Structural Defect is defined by three criteria: first, the defects are prenatal in origin; second, the defect(s) affect (or have the propensity to affect) the health, survival, or physical or cognitive functioning of the individual; third, at least one of the following requirements must be met: a) Alterations in the internal anatomy that are present at the time of live birth, and that persist beyond the immediate peripartum period unless surgically repaired; OR b) Alterations in the internal anatomy that are present at the time of the stillbirth or of the spontaneous or therapeutic abortion; fourth, at least one of the following requirements must be met: a) Documented confirmation in the medical record that the anomaly was present at the time of live birth or at the time of fetal demise, and that the anomaly was diagnosed by a trained maternal or a child health care provider who has minimal experience diagnosing congenital anomalies; OR b) Confirmed by claims data (ICD-9/ICD-10 diagnoses).	C126852	GAIA Major Congenital Anomalies Level of Diagnostic Certainty Terminology
C128761	GAIA Level 4 Postnatally Diagnosed Congenital Microcephaly	GAIA Level 4 Postnatally Diagnosed Congenital Microcephaly is defined by two criteria: first, a live birth, stillbirth, or spontaneous or therapeutic abortion; second, a diagnosis of congenital microcephaly based on either a physical inspection without head circumference (HC) measurement, OR  an ICD-9-CM or ICD-10-CM code that does not meet the validated algorithm criteria used in the case definition for GAIA Level 3 Postnatally Diagnosed Congenital Microcephaly.	Level 4 Postnatally Diagnosed Congenital Microcephaly		Level 4 Postnatally Diagnosed Congenital Microcephaly is defined by two criteria: first, a live birth, stillbirth, or spontaneous or therapeutic abortion; second, a diagnosis of congenital microcephaly based on either a physical inspection without head circumference (HC) measurement, OR  an ICD-9-CM or ICD-10-CM code that does not meet the validated algorithm criteria used in the case definition for Level 3 Postnatally Diagnosed Congenital Microcephaly.	C128700	GAIA Congenital Microcephaly Level of Diagnostic Certainty Terminology
C128766	GAIA Level 4 Prenatally Diagnosed Congenital Microcephaly	GAIA Level 4 Prenatally Diagnosed Congenital Microcephaly is defined by three criteria: first, the fetus is at least 24 weeks gestational age (GA), with GA based on certain last menstrual period (LMP) date with confirmatory first or second trimester ultrasound (US) scan, OR uncertain LMP with second trimester ultrasound, intrauterine insemination (IUI), OR embryo transfer, OR certain or uncertain LMP with fundal height and no confirmatory first or second trimester scan; second, HC 2 SD below mean or less than 3 percentile according to fetal US scan using appropriate standardized reference charts according to GA and gender for the population (e.g., WHO growth reference charts if GA greater than or equal to 37 weeks and Intergrowth-21st reference charts for GA 24-36 weeks); third, HC at birth or autopsy is in the normal range using appropriate standardized reference charts according to GA and gender for the population, which means that this is NOT a case of prenatally diagnosed congenital microcephaly.	Level 4 Prenatally Diagnosed Congenital Microcephaly		Level 4 Prenatally Diagnosed Congenital Microcephaly is defined by three criteria: first, the fetus is at least 24 weeks gestational age (GA), with GA based on certain last menstrual period (LMP) date with confirmatory first or second trimester ultrasound (US) scan, OR uncertain LMP with second trimester ultrasound, intrauterine insemination (IUI), OR embryo transfer, OR certain or uncertain LMP with fundal height and no confirmatory first or second trimester scan; second, HC 2 SD below mean or less than 3 percentile according to fetal US scan using appropriate standardized reference charts according to GA and gender for the population (e.g., WHO growth reference charts if GA greater than or equal to 37 weeks and Intergrowth-21st reference charts for GA 24-36 weeks); third, HC at birth or autopsy is in the normal range using appropriate standardized reference charts according to GA and gender for the population, which means that this is NOT a case of prenatally diagnosed congenital microcephaly.	C128700	GAIA Congenital Microcephaly Level of Diagnostic Certainty Terminology
C128783	GAIA Level 4 Second Trimester Spontaneous Abortion	GAIA Level 4 Second Trimester Spontaneous Abortion is defined by two criteria: first, it does not qualify as either a Level 1 or a Level 2 Second Trimester Spontaneous Abortion; second, a maternal self-report or documentation in the medical record of a pregnancy loss without sufficient ultrasound or laboratory evidence to confirm.	Level 4 Second Trimester Spontaneous Abortion		Level 4 Second Trimester Spontaneous Abortion is defined by two criteria: first, it does not qualify as either a Level 1 or a Level 2 Second Trimester Spontaneous Abortion; second, a maternal self-report or documentation in the medical record of a pregnancy loss without sufficient ultrasound or laboratory evidence to confirm.	C128705	GAIA Spontaneous Abortion and Ectopic Pregnancy Level of Diagnostic Certainty Terminology
C128738	GAIA Level 4 Small for Gestational Age	GAIA Level 4 Small for Gestational Age is defined by one of the following three criteria: first, the infant is noted to be small, but has no documented weight; second, the gestational age is assessed by infant examination only; third, the diagnosis is extracted from either billing codes or a chart with no documentation of the actual birth weight or the gestational age.	Level 4 Small for Gestational Age		Level 4 Small for Gestational Age is defined by one of the following three criteria: first, the infant is noted to be small, but has no documented weight; second, the gestational age is assessed by infant examination only; third, the diagnosis is extracted from either billing codes or a chart with no documentation of the actual birth weight or the gestational age.	C128703	GAIA Small for Gestational Age Level of Diagnostic Certainty Terminology
C129606	GAIA Level 5 Small for Gestational Age	GAIA Level 5 Small for Gestational Age is defined by either no evidence of Small for Gestational Age (SGA) or a confirmed diagnosis other than SGA.	Level 5 Small for Gestational Age		Level 5 Small for Gestational Age is defined by either no evidence of Small for Gestational Age (SGA) or a confirmed diagnosis other than SGA.	C128703	GAIA Small for Gestational Age Level of Diagnostic Certainty Terminology
C4371	Gestational Hypertension	A blood pressure elevation after 20 weeks of gestation in the absence of either proteinuria or systemic findings like thrombocytopenia, impaired liver function, progressive renal insufficiency, pulmonary edema or the new-onset of cerebral or visual disturbances.	Gestational Hypertension		Gestational Hypertension is defined by four criteria: First, the gestational age of the pregnancy must be greater than or equal to 20 weeks; Second, a diagnosis of new onset maternal hypertension (systolic blood pressure greater than or equal to 140mmHg and/or diastolic blood pressure greater than or equal to 90mmHg) that is sustained on two measurements over a minimum of one hour; Third, the absence of any severe features (see preeclampsia with severe features category); Fourth, the absence of proteinuria.	C126860	GAIA Preeclampsia Level of Diagnostic Certainty Terminology
C113382	Intrapartum Stillbirth	Fetal death greater than or equal to 20 weeks of gestation during labor with Apgar scores of 0 at 1 minute, 5 minutes and beyond.	Intrapartum Stillbirth		A condition characterized by foetal death occurring after the onset of labor and prior to delivery. The infant is born without signs of life. Documentation of a live foetus prior to or at the onset of labor exists. Additional findings that might be helpful to differentiate between antepartum and intrapartum stillbirth at the time of delivery include the following criteria: a) Physical Examination: foetuses who died antepartum can have skin changes consistent with maceration, tissue injury, meconium staining, and edema; b) Laboratory/pathology: autopsy examination of the foetus and/or the placenta.	C126856	GAIA Stillbirth Level of Diagnostic Certainty Terminology
C114091	Live Birth	The complete expulsion or extraction from the mother of a fetus, irrespective of the duration of pregnancy, which, after such expulsion or extraction, breathes or shows any other evidence of life, such as beating of the heart, pulsation of the umbilical cord, or definite movement of voluntary muscles.	Live Birth	Live Born	An infant delivered, that breathes/shows any evidence of life (e.g. beating heart, pulsation of umbilical cord) or definite movement of voluntary muscles.	C126853	GAIA Neonatal Death Level of Diagnostic Certainty Terminology
C34724	Low Birth Weight	A birth weight that is less than 2500 grams.	Low Birth Weight			C128701	GAIA Low Birth Weight Level of Diagnostic Certainty Terminology
C127956	Major Congenital Anomaly	A major congenital anomaly is a structural or functional defect with the following three characteristics: 1) Of prenatal origin; 2) Present at the time of live birth or fetal demise, or in utero; 3) Affecting (or has the propensity to affect) the health, survival, or physical or cognitive functioning of the individual.	Major Congenital Anomaly		A major congenital anomaly is a structural or functional defect with the following three characteristics: 1) Of prenatal origin; 2) Present at the time of live birth or fetal demise, or in utero; 3) Affecting (or has the propensity to affect) the health, survival, or physical or cognitive functioning of the individual.	C126852	GAIA Major Congenital Anomalies Level of Diagnostic Certainty Terminology
C111860	Maternal Mortality	The death of a woman while pregnant or within 42 days of the end of the pregnancy, irrespective of the duration or anatomic site of the pregnancy, due to any cause related to or aggravated by the pregnancy or its management, but not from accidental or incidental causes.	Maternal Death		The death of a woman while pregnant or within 42 days of termination of pregnancy, irrespective of the duration and the site of the pregnancy (as defined by Maternal Death guidelines: http:www.brightoncollaboration.org).	C126859	GAIA Postpartum Hemorrhage Level of Diagnostic Certainty Terminology
C128741	Mixed Failure to Thrive	Failure to thrive due to both organic and non-organic causes.	Mixed Failure to Thrive		Failure to thrive due to both organic and non-organic causes.	C128704	GAIA Failure to Thrive Level of Diagnostic Certainty Terminology
C128042	Moderate to Late Preterm Infant	A baby born alive with a gestational age between 32 to less than 37 weeks.	Moderate to Late Preterm Infant		A baby born alive with a gestational age between 32 to less than 37 weeks. (WHO)	C126855	GAIA Preterm Birth Level of Diagnostic Certainty Terminology
C128714	Morbidly Adherent Placenta	A condition in which the placenta implants abnormally into the uterine myometrium, rather than implanting into the uterine decidua basalis as is normal.	Morbidly Adherent Placentation		A condition in which the placenta implants abnormally into the uterine myometrium, rather than implanting into the uterine decidua basalis as is normal.	C128706	GAIA Antenatal Bleeding Level of Diagnostic Certainty Terminology
C128740	Non-Organic Failure to Thrive	Failure to thrive caused by inadequate intake due to environmental influences, stimulus deprivation- poverty, feeding techniques, or psychological reason, and without any apparent growth-inhibiting organic disorder.	Non-Organic Failure to Thrive		Failure to thrive caused by inadequate intake due to environmental influences, stimulus deprivation- poverty, feeding techniques, or psychological reason, and without any apparent growth-inhibiting organic disorder.	C128704	GAIA Failure to Thrive Level of Diagnostic Certainty Terminology
C128739	Organic Failure to Thrive	Failure to thrive (FTT), that occurs in less than five percent of FTT cases; it is caused by acute or chronic disorders that interfere with nutritional uptake, including cleft palate, malabsorption due to cystic fibrosis, and short gut syndrome.	Organic Failure to Thrive		Failure to thrive (FTT), that occurs in less than five percent of FTT cases; it is caused by acute or chronic disorders that interfere with nutritional uptake, including cleft palate, malabsorption due to cystic fibrosis, and short gut syndrome.	C128704	GAIA Failure to Thrive Level of Diagnostic Certainty Terminology
C113099	Pediatric Failure to Thrive	Less than normal weight gain in an infant or child, which may include poor linear and head growth.	Failure to Thrive			C128704	GAIA Failure to Thrive Level of Diagnostic Certainty Terminology
C26858	Placenta Previa	A condition in which the placenta covers or is within 1 cm of the cervical os.	Placenta Previa		A condition in which the placenta partially or completely overlies the internal cervical os.	C128706	GAIA Antenatal Bleeding Level of Diagnostic Certainty Terminology
C26685	Placental Abruption	Placental separation from the uterus with bleeding (concealed or vaginal) before fetal birth, with or without maternal/fetal compromise. (reVITALize)	Placental Abruption		A condition in which the placenta detaches prematurely from its implantation site.	C128706	GAIA Antenatal Bleeding Level of Diagnostic Certainty Terminology
C85021	Preeclampsia	A systolic blood pressure of 140 mmHg or higher, or a diastolic blood pressure of 90 mmHg or higher on two occasions at least 4 hours apart (or greater than or equal to 160/110 mmHg within a short interval) after 20 weeks of gestation in a woman with previously normal blood pressure. It may present with proteinuria but if not, it may be associated with thrombocytopenia, impaired liver function, progressive renal insufficiency, pulmonary edema, or new-onset cerebral or visual disturbances.	Preeclampsia		Preeclampsia is defined by three criteria: First, the gestational age of the pregnancy must be greater than or equal to 20 weeks; Second, a diagnosis of new onset maternal hypertension (systolic blood pressure greater than or equal to 140mmHg and/or diastolic blood pressure greater than or equal to 90mmHg) that is sustained on two measurements over a minimum of one hour; Third, a diagnosis of new onset proteinuria.	C126860	GAIA Preeclampsia Level of Diagnostic Certainty Terminology
C49642	Preterm Infant	A newborn infant less than 37 weeks, 0 days gestational age.	Preterm Infant		A baby born alive before 37 weeks of pregnancy are completed. (WHO)	C126855	GAIA Preterm Birth Level of Diagnostic Certainty Terminology
C128780	Second Trimester Spontaneous Abortion	Pregnancy loss between 14 weeks 0 days and 21 weeks 6 days gestation.	Second Trimester Spontaneous Abortion		Pregnancy loss between 14 weeks 0 days and 21 weeks 6 days gestation.	C128705	GAIA Spontaneous Abortion and Ectopic Pregnancy Level of Diagnostic Certainty Terminology
C112843	Severe Preeclampsia	Preeclampsia with a systolic blood pressure of 160 mmHg or higher, or a diastolic blood pressure of 110 mmHg or higher on two occasions at least 4 hours apart while on bedrest. It is associated with thrombocytopenia (platelets less than 100,000 per microliter), impaired liver function (twice normal elevation of hepatic transaminases; severe, persistent right upper quadrant or epigastric pain), progressive renal insufficiency (serum creatinine greater than 1.1 mg/dL or doubling of baseline in the absence of other renal disease), pulmonary edema, or new-onset cerebral or visual disturbances.	Preeclampsia with Severe Features		Preeclampsia with Severe Features is defined by three criteria: First, the gestational age of he pregnancy must be equal to or greater than 20 weeks; Second, a diagnosis of new onset maternal hypertension (systolic blood pressure equal or greater than 140mmHg and /or diastolic blood pressure equal to or greater than 90mmHg) that is sustained on two measurements over a minimum of one hour; Third, at least one of the criteria for severe disease.	C126860	GAIA Preeclampsia Level of Diagnostic Certainty Terminology
C34336	Spontaneous Abortion	Fetal loss at less than 20 weeks of gestation.	Spontaneous Abortion		Early pregnancy loss.	C128705	GAIA Spontaneous Abortion and Ectopic Pregnancy Level of Diagnostic Certainty Terminology
C49151	Stillbirth	A fetus of at least 20 weeks gestation, or of a birth weight of at least 350 grams if the gestational age is unknown, that is born without signs of life at the time of delivery, and with an Apgar score of zero at both one and five minutes.	Stillbirth		Foetal death occurring before birth after a selected, pre-defined duration of gestation. The death of the foetus could have occurred before the onset of labor (antepartum) or at the time of delivery (intrapartum). For all levels of diagnostic certainty, the definition of stillbirth is defined by the two following criteria: First, determination of absence of signs of life in the foetus or newborn; Second, determination of foetal/newborn gestational age through maternal information or through foetal/newborn evaluation.	C126856	GAIA Stillbirth Level of Diagnostic Certainty Terminology
C128716	Uterine Rupture	The complete, nonsurgical disruption of all layers of the uterus.	Uterine Rupture		The complete, nonsurgical disruption of all layers of the uterus.	C128706	GAIA Antenatal Bleeding Level of Diagnostic Certainty Terminology
C87127	Vasa Previa	Umbilical blood vessels that have inserted into the amniotic membrane (membranous insertion) that in turn are above or adjacent to the cervical os and are at risk of rupture.	Vasa Previa		A condition in which fetal blood vessels reside within the amniotic membranes and traverse either across the internal cervical os or within 2 centimeters of the os.	C128706	GAIA Antenatal Bleeding Level of Diagnostic Certainty Terminology
C114935	Very Low Birth Weight	Birth weight less than 1500 grams.	Very Low Birth Weight			C128701	GAIA Low Birth Weight Level of Diagnostic Certainty Terminology
C118677	Very Preterm Infant	A newborn infant greater than 28 weeks, 0 days and less than 34 weeks, 0 days.	Very Preterm Infant		A baby born alive with a gestational age between 28 to less than 32 weeks. (WHO)	C126855	GAIA Preterm Birth Level of Diagnostic Certainty Terminology